THERMOPLASTIC SILOXANE-URETHANE COPOLYMER DEVELOPMENT

Information

• Research Project
• 3498518

• ApplicationId

  3498518

• Core Project Number

  R43GM044539

• Full Project Number

  1R43GM044539-01

• Serial Number

  44539

• FOA Number

• Sub Project Id

• Project Start Date

  1/15/1990 - 34 years ago

• Project End Date

  7/15/1991 - 33 years ago

• Program Officer Name

• Budget Start Date

  1/15/1990 - 34 years ago

• Budget End Date

  7/15/1991 - 33 years ago

• Fiscal Year

  1990

• Support Year

  1

• Suffix

• Award Notice Date

  1/18/1990 - 34 years ago

Organizations

• POLYMER TECHNOLOGY GROUP, INC.

This project would test the hypothesis that biostability of thermoplastic polyurethanes (TPU) can be improved by replacing all or part of the polyether soft segment with telechelic polydimethylsiloxane (PSX) oligomer during synthesis. This approach is based on the reported improvement in-vivo stability of solvent-cast polyurethanes through the admixture or grafting of reactive PSX into/onto urethane vased polymers and the known in-vivo stability of PSX. In Phase I the subcutaneous in-vivo stability of several different polyurethane will be determined. Aromatic TPUs from PSX, polytetramethyleneoxide and polyethyleneoxide and several PSX/polyether terpolymer polyurethane films will be characterized after explantation by bulk and surface analytical methods capable of detecting molecular weight reduction and changes in surface chemistry and morphology associated with the degradation process. Positive phase I results will be utilized in Phase II to complete the development and commercialization of a family of biomedical PSX-TPUs. These materials will be suitable for solvent casting, extrusion and injection molding. They will combine the biodegradation resistance and desirable surface properties of PSX, with the processing ease and wide range of bulk properties available in conventional TPUs.

IC Name

• Activity

  R43

• Administering IC

  GM

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  821

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  POLYMER TECHNOLOGY GROUP, INC.

• Organization Department

• Organization DUNS

• Organization City

  BERKELEY

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  94710

• Organization District

  UNITED STATES