THERMORESPONSIVE POLYMER AND PRODUCTION METHOD THEREOF

Abstract

A material which expresses its critical solution temperature even in an aqueous solution containing a buffer or salt, and at the same time, shows small variation width of the critical solution temperature even when concentration of salt or the like contained in water, a buffer liquid or the like is different, interacts with a substance such as a component in the living body and can therefore be used efficiently in the isolation of substances, is provided. A monomer represented by a formula (1) and a thermoresponsive polymer which contains said monomer as a polymerization component.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graph showing upper critical solution temperature of the thermoresponsive polymer of the invention obtained in Example 1.

FIG. 2 is a graph showing upper critical solution temperature of the thermoresponsive polymer of the invention obtained in Example 2.

FIG. 3 is a graph showing upper critical solution temperature and lower critical solution temperature of the thermoresponsive polymer of the invention obtained in Example 3.

Claims

1. A monomer represented by a formula (1):

2. The monomer described in claim 1, wherein, in the formula (1), R1 is hydrogen or methyl, and R2 is carbamoyl, methyl wherein one or more hydrogen atoms are substituted by carbamoyl, or ethyl wherein one or more hydrogen atoms are substituted by carbamoyl.

3. The monomer described in claim 2, wherein, in the formula (1), R1 is hydrogen, and R2 is —CH2—CONH2 or —(CH2)2—CONH2.

4. The monomer described in claim 2, wherein, in the formula (1), R1 is methyl, and R2 is —CH2—CONH2 or —(CH2)2—CONH2.

5. A thermoresponsive polymer obtained by polymerizing the monomer represented by the formula (1) described in claim 1.

6. A thermoresponsive polymer obtained by polymerizing only the monomer represented by the formula (1) described in claim 1.

7. The thermoresponsive polymer described in claim 5, which has an number average molecular weight of from 103 to 106.

8. A method for producing the thermoresponsive polymer described in claim 5, which comprises treating a polymerization solvent containing a monomer represented by the following formula (1) and an initiator with a temperature or light capable of generating a radical from the initiator to perform a polymerization:

9. The thermoresponsive polymer described in claim 6, which has an number average molecular weight of from 103 to 106.

10. A method for producing the thermoresponsive polymer described in claim 6, which comprises treating a polymerization solvent containing a monomer represented by the following formula (1) and an initiator with a temperature or light capable of generating a radical from the initiator to perform a polymerization: