Claims
- 1. A compound of the formula ##STR6## wherein A is --CO-- or --CHOH--, B is CH.sub.2 --CH.sub.2 --, R.sup.1 is H or alkyl with 1 to 4 carbon atoms, m is a whole number from 0 to 5, n is a whole number from 0 to 3, R.sup.2 is alkoxy of 1 to 4 carbon atoms, phenoxy, pyridyl, thienyl, naphthyl, phenoxy substituted by F, Cl, Br, OH, OCH.sub.3, CH.sub.3 or CF.sub.3, and R.sup.3 is H, methyl or ethyl, and the physiologically acceptable salts thereof.
- 2. A compound of claim 1 wherein R.sup.2 is phenoxy or phenoxy substituted by F, Cl, Br, OH, OCH.sub.3, CH.sub.3 or CF.sub.3.
- 3. A compound of claim 1 wherein R.sup.2 is alkoxy of 1 to 4 carbon atoms.
- 4. A compound of claim 1 wherein R.sup.1 is H.
- 5. A compound of claim 1 wherein R.sup.3 is H.
- 6. A compound of claim 1 wherein A is --CO--.
- 7. A compound of claim 1 wherein A is --CHOH--.
- 8. A compound of claim 1 wherein m is 0 or 1.
- 9. A compound of claim 2 wherein m is 0 or 1, n is 0 or 1, R.sup.1 is H and R.sup.3 is H.
- 10. A compound of claim 9 wherein A is --CO--.
- 11. A compound of claim 9 wherein A is --CHOH--.
- 12. A compound of claim 1 wherein R.sup.1 is H, R.sup.3 is H, m is 0 or 1 and R.sup.2 is alkoxy of 1 to 4 carbon atoms.
- 13. A compound of claim 1, 11,15-dihydroxy-16-p-fluorophenoxy-15-methyl-9-oxo-17,18,19,20-tetranor-13-thia-prostanoic acid.
- 14. A compound of claim 1, 9,11,15-trihydroxy-16-p-fluorophenoxy-15-methyl-17,18,19,20-tetranor-13-thia-prostanoic acid.
- 15. A compound of claim 1, 11,15-dihydroxy-16-m-trifluoromethylphenoxy-9-oxo-17,18,19,20-tetranor-13-thia-prostanoic acid.
- 16. A compound of claim 1, 11,15-dihydroxy-15-methyl-9-oxo-13-thia-18-oxa-prostanoic.
- 17. A compound of claim 1, 11,15-dihydroxy-15-methyl-9-oxo-13-thia-19-oxa-prostanoic acid.
- 18. A compound of claim 1, 11,15-dihydroxy-15-(4-pyridyl)-9-oxo-13-thia-17,18,19,20-tetranor-prostanoic acid methyl ester.
- 19. A compound of claim 1, 11,15-dihydroxy-15-(2-naphthyl)-9-oxo-13-thia-17,18,19,20-tetranor-prostanoic acid.
- 20. A compound of claim 1, 11,15-dihydroxy-15-methyl-16-m-trifluoromethylphenoxy-9-oxo-13-thia-17,18,19,20-tetranorprostanoic acid.
- 21. A pharmaceutical composition comprising a blood pressure lowering amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
- 22. A method of lowering the blood pressure in humans having abnormally high blood pressure which comprises administering to the affected patient an amount of a compound of claim 1 effective to lower the blood pressure thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2422924 |
May 1974 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 576,140, filed May 9, 1975.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3932487 |
Kramer et al. |
Jan 1976 |
|
4001286 |
Bundy |
Jan 1977 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
576140 |
May 1975 |
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