Claims
- 1. A thiazine derivative of the following formula [I]: ##STR170## wherein R.sup.1 and R.sup.2 are both hydrogen atoms; R.sup.3 and R.sup.4 are both hydrogen atoms; X is a sulfur atom; R.sup.5 is a hydrogen atom; R.sup.6 is halogeno substituted phenyl; Z.sup.1 is two hydrogen atoms; Z.sup.2 is an oxygen atoms; A is lower alkylene; R.sup.7 and R.sup.8 are the same or different and are each lower alkyl; or a pharmaceutically acceptable salt thereof.
- 2. The compound according to claim 1, wherein R.sup.6 is chlorphenyl, and R.sup.7 and R.sup.8 are both methyl or ethyl.
- 3. 2-(4-Chlorophenyl)-4-(diethylamino)acetyl-3,4-dihydro-2H-1,4-benzothiazine or a pharmaceutically acceptable salt thereof.
- 4. A pharmaceutical composition which comprises a therapeutically effective amount of a thiazine derivative of the formula [I] as set forth in claim 1 in admixture of a conventional pharmaceutically acceptable carrier or diluent.
- 5. A method for the prophylaxis or treatment of ischemic encephalopathia in a warm-blooded animal which comprises administering an effective amount of a thiazine derivative of the formula [I] as set forth in claim 1 to said warm-blooded animal suffering from the disease.
Priority Claims (3)
Number |
Date |
Country |
Kind |
2-31068 |
Feb 1990 |
JPX |
|
2-56220 |
Mar 1990 |
JPX |
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2-59328 |
Mar 1990 |
JPX |
|
Parent Case Info
This application is a divisional of copending application Ser. No. 07/648,891, filed on Jan. 31, 1991 now U.S. Pat. No. 5,246,929, the entire contents of which are hereby incorporated by reference.
US Referenced Citations (10)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0116368 |
Aug 1984 |
EPX |
2332756 |
Jun 1977 |
FRX |
1173942 |
Dec 1969 |
GBX |
Non-Patent Literature Citations (4)
Entry |
Iwao et al.; "Chemical Abstract" vol. 104(13), (1985) #109666P. |
Iwao et al., "Chemical Abstract" vol. 102(3) (1984) #24637P. |
George Roger Clemo et al., Journal of the Chemical Society Transactions, vol. 121, pp. 642-649 (1922). |
Abstract of Japan 60-166674 (A), vol. 10, No. 13(C-323) (2070), Jan. 1986. |
Divisions (1)
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Number |
Date |
Country |
Parent |
648891 |
Jan 1991 |
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