Claims
- 1. A compound of the formula: ##STR6## wherein
- R.sup.1 is hydrogen or acyl which may be substituted with halogen,
- R.sup.2 is hydrogen, lower alkyl, hydroxy(lower)alkyl, halogen or carboxy,
- A is ##STR7## wherein m is 0, 1, or 2, and
- R.sup.3 is an unsaturated heterocyclic group selected from the group consisting of pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazolyl, tetrazolyl, and thiadiazolyl;
- wherein said unsaturated heterocyclic group may be substituted 1 to 4 times with lower alkyl, amino, hydroxy, or halo(lower)alkyl, or pharmaceutically acceptable salts thereof.
- 2. A compound of the formula: ##STR8## wherein R.sup.1 is lower alkanesulfonyl which may be substituted with halogen,
- R.sup.2 is hydrogen, lower alkyl, hydroxy(lower)alkyl, halogen or carboxy,
- A is ##STR9## wherein m is 0, 1 or 2, and
- R.sup.3 is an unsaturated heterocyclic group selected from the group consisting of pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazolyl, tetrazolyl and thiadiazolyl;
- wherein said unsaturated heterocyclic group may be substituted 1 to 4 times with lower alkyl, amino, hydroxy, or halo(lower)alkyl,
- or pharmaceutically acceptable salts thereof.
- 3. A pharmaceutical composition which comprises, as an active ingredient, a compound of claim 1 or 2 or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers.
- 4. The compound of claim 1, wherein R.sup.1 is hydrogen, lower alkanoyl or benzoyl which may be substituted with halogen.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8918045.9 |
Aug 1989 |
GBX |
|
9003930.6 |
Feb 1990 |
GBX |
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Parent Case Info
This is a divisional of application Ser. No. 07/867,085, filed Apr. 14, 1992, U.S. Pat. No. 5,256,675, which is a continuation of application Ser. No. 07/554,314, filed Jul. 19, 1990, abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4649146 |
Takaya et al. |
Mar 1987 |
|
4735957 |
Takaya et al. |
Apr 1988 |
|
4921887 |
Matsuo et al. |
May 1990 |
|
5256675 |
Matsuo et al. |
Oct 1993 |
|
Non-Patent Literature Citations (3)
Entry |
Gibbs et al., "Sulfur Derivatives of Thiazoles" Chemical Society Journal, (1945) pp. 925-926. |
Claub et al., ".beta.-Lactame mit uber Heteroatomegebundenen Substituenten" (1974) Liebigs Annalen Chemi., 539. |
M. Ohta et al., Chemical Abstracts 45:7111g (1951). |
Divisions (1)
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Number |
Date |
Country |
Parent |
867085 |
Apr 1992 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
554413 |
Jul 1990 |
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