Claims
- 1. A compound selected from those of formula (I): ##STR48## in which: R.sub.1 represents:
- a group of formula (B): ##STR49## in which R.sub.2 is a group selected from:
- (1)--R'.sub.2 --, wherein R'.sub.2 represents a group --(CH.sub.2).sub.n -- or ##STR50## wherein n is 1 to 6, inclusive, R'.sub.2 being unsubstituted or substituted in the alkylene moiety by lower alkyl, aryl or aryl-lower alkyl,
- and (2) ##STR51## wherein p is 1, 2 or 3 and R.sub.b represents a radical selected from hydroxy, lower alkoxy, lower alkylcarbonyloxy, aryloxy, and aryl-lower alkoxy,
- one of R.sub.3 and R.sub.4, which are identical or different, each independently of the other represents a radical selected from:
- hydrogen, and
- lower alkyl that is unsubstituted or substituted by one or more radicals selected from halogen, hydroxy, and lower alkoxy, the other of R.sub.3 and R.sub.4 being a radical ##STR52## in which q represents 0 or is 1 to 4 inclusive and Z represents oxygen or two hydrogen atoms, and in which,
- or R.sub.3 and R.sub.4, together with the nitrogen atom carrying them, form:
- an unsubstituted or substituted
- wherein, unless indicated otherwise:
- the expression "substituted" associated with the term "" phthalimide indicates that the phthalimide is substituted by one or more radicals selected from:
- halogen,
- hydroxy,
- oxo,
- lower alkyl,
- lower alkoxy, and
- lower alkoxycarbonyl,
- the term "aryl" means a phenyl or naphthyl group,
- and the terms "lower alkyl" and "lower alkoxy" indicate linear or branched groups containing 1 to 6 carbon atoms inclusive, an optical isomer, in pure form or in the form of a mixture, and an addition salt thereof with a Pharmaceutically-acceptable acid or base.
- 2. A compound according to claim 1 selected from those in which R.sub.2 represents a group ##STR53## wherein n represents an integer of 1 to 6, inclusive, it being possible for the groups --(CH.sub.2).sub.n -- and ##STR54## to be substituted in their alkylene moiety by lower alkyl, aryl, or aryl-lower alkyl, an optical isomer, in pure form or in the form of a mixture, and an addition salt thereof with a pharmaceutically-acceptable acid or base.
- 3. A compound according to claim 1 selected from those in which R.sub.2 represents a group ##STR55## an optical isomer, in pure form or in the form of a mixture, and an addition salt thereof with a pharmaceutically-acceptable acid or base.
- 4. A pharmaceutical composition useful in combatting anxiety and depression containing as active ingredient an effective amount of a compound according to claim 1, in combination with a pharmaceutically-acceptable excipient or carrier.
- 5. A method of treating a mammal afflicted with a disorder selected from anxiety and depression, comprising the step of administering to the said mammal an amount of a compound as claimed in claim 1 which is effective for alleviation of said disorder.
- 6. A method of treating a mammal afflicted with depression comprising the step of administering to the said mammal an amount of a compound as claimed in claim 1 which is effective for alleviation of said disorder.
- 7. A compound according to claim 1 which is 8-[(4-phthalimido-butyl)oxy]thiochroman.
- 8. A compound according to claim 1 which is 8-{{2-[N,N-bis-(4-phthalimidobutyl)amino]ethyl}oxy}thiochroman
- 9. A compound according to claim 1 which is 8-{{(2-[N-(4-phthalimidobutyl)amino]ethyl}oxy}thiochroman.
Priority Claims (1)
Number |
Date |
Country |
Kind |
92 05960 |
May 1992 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed U.S. application Ser. No. 08/133,901, filed Oct. 12, 1993, which in turn is a division of our prior-filed U.S. application Ser. No. 08/062,424, filed May 17, 1993, now U.S. Pat. No. 5,332,741.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3705167 |
Malen et al. |
Dec 1972 |
|
5071858 |
Hutchison |
Dec 1991 |
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Foreign Referenced Citations (5)
Number |
Date |
Country |
389425 |
Sep 1990 |
EPX |
412939 |
Feb 1991 |
EPX |
471515 |
Feb 1992 |
EPX |
9853 |
Jul 1991 |
WOX |
6084 |
Apr 1992 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Chem. Abst. 90(15): 115458f(1978). |
Vincent et al, Chem. Abst. 85(7): 46420v(1976). |
Divisions (2)
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Number |
Date |
Country |
Parent |
133901 |
Oct 1993 |
|
Parent |
62424 |
May 1993 |
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