Claims
- 1. A compound selected from those of formula (I): ##STR54## in which: R.sub.1 represents:
- group of formula (B): ##STR55## in which R.sub.2 is a group selected from:
- --R'.sub.2 --, wherein R'.sub.2 represents a group ##STR56## wherein n is 1 to 6, inclusive R'.sub.2 being unsubstituted or substituted in the alkylene moiety by lower alkyl, aryl or aryl-lower alkyl, and ##STR57## wherein p is 1, 2 or 3 and R.sub.b represents a radical selected from hydroxy, lower alkoxy, lower alkylcarbonyloxy, aryloxy, and aryl-lower alkoxy,
- one of R.sub.3 and R.sub.4, which are identical or different, each independently of the other represents a radical selected from:
- hydrogen, and
- lower alkyl that is unsubstituted or substituted by one or more radicals selected from halogen, hydroxy, and lower alkoxy, the other of R.sub.3 and R.sub.4 being cycloalkyl, cycloalkyl-lower alkyl, or, di(cycloalkyl)-lower alkyl, each of which is unsubstituted or substituted in the cycloalkyl moieties by one or more radicals selected from halogen, oxo, lower alkyl, and lower alkoxy, or aryl or adamantyl, or aryl-lower alkyl or adamantyl-lower-alkyl, in each case unsubstituted or substituted in the cyclic nucleus by one or more radicals selected from halogen, hydroxy, lower alkyl, lower alkoxy, and trifluoromethyl,
- wherein, unless indicated otherwise:
- the term "aryl" means phenyl or naphthyl,
- and the terms "lower alkyl" and "lower alkoxy" indicate linear or branched groups containing 1 to 6 carbon atoms inclusive, an optical isomer, in pure form or in the form of a mixture, and an addition salt thereof with a pharmaceutically-acceptable acid or base.
- 2. A compound according to claim 1 selected from those in which R.sub.2 represents a group ##STR58## wherein n represents an integer of 1 to 6, inclusive, it being possible for the groups --(CH.sub.2).sub.n and ##STR59## to be substituted in their alkylene moiety by lower alkyl, aryl, or aryl-lower alkyl, an optical isomer, in pure form or in the form of a mixture, and an addition salt thereof with a pharmaceutically-acceptable acid or base.
- 3. A compound according to claim 1 selected from those in which R.sub.2 represents a group ##STR60## an optical isomer, in pure form or in the form of a mixture, and an addition salt thereof with a pharmaceutically-acceptable acid or base.
- 4. A pharmaceutical composition containing as active ingredient an effective anti-anxiety or anti-depressive amount of a compound according to claim 1 in combination with a pharmaceutically-acceptable excipient or carrier.
- 5. A method of treating a mammal afflicted with a disorder selected from anxiety and depression, and comprising the step of administering to the said mammal an amount of a compound as claimed in claim 1 which is effective for alleviation of said disorder.
- 6. A method of treating a mammal afflicted with depression comprising the step of administering to the said mammal an amount of a compound as claimed in claim 1 which is effective for alleviation of said disorder.
- 7. A compound according to claim 1 which is 8-{{2-hydroxy-3-[(3-phenylpropyl)amino]propyl}oxy}thiochroman.
- 8. A compound according to claim 1 which is 8-{{2-hydroxy-3-[(4-phenylbutyl)amino]propyl}oxy}thiochroman.
- 9. A compound according to claim 1 which is 8-{{2-methoxy-3-[(4-phenylbutyl)amino]propyl}oxy}thiochroman.
- 10. A compound according to claim 1 which is 8-{{3-[(cyclooctyl)amino]-2-hydroxypropyl}oxy}thiochroman.
- 11. A compound according to claim 1 which is 8-{{3-[(adamantyl)amino]-2-hydroxypropyl}oxy}thiochroman.
Priority Claims (1)
Number |
Date |
Country |
Kind |
92 05960 |
May 1992 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed copending U.S. application Ser. No. 08/133,901, filed Oct. 12, 1993, which in turn is a division of our prior-filed copending U.S. application Ser. No. 08/062,424, filed May 17, 1993, now U.S. Pat No. 5,332,741.
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Number |
Name |
Date |
Kind |
3705167 |
Malen et al. |
Dec 1972 |
|
5071858 |
Hutchison |
Dec 1991 |
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Country |
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Non-Patent Literature Citations (2)
Entry |
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Divisions (2)
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Number |
Date |
Country |
Parent |
133901 |
Oct 1993 |
|
Parent |
62424 |
May 1993 |
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