Three dimensional coordinates of melanocortin-4 receptors

Abstract

Three-dimensional coordinates of melanocortin-4 receptors are useful in computer aided drug design.

Description

FIELD OF THE INVENTION

The present invention relates to three-dimensional structures of G protein-coupled receptors, especially melanocortin-4 receptors, and structures derived therefrom.

BACKGROUND OF THE INVENTION

I. GPCRs

Most eukaryotic organisms utilize guanine nucleotide-binding regulatory protein (hereinafter, referred to as “G protein”)-coupled receptors (G protein-coupled receptors; hereinafter, frequently referred to as “GPCRs”) to respond to a variety of stimuli such as Ca²⁺, amines, hormones, peptides, and even large proteins. Each GPCR is composed of an extracellular region, an intracellular region and a transmembrane bundle of seven α-helices. The binding of specific ligands to the extracellular or transmembrane domain evokes conformational changes that are transmitted to the intracellular region. The conformational switch from inactive to active state in the intracellular region produces a catalytically competent receptor that is responsible for binding and nucleotide exchange (GDP⇄GTP) on the α-subunit of several hundreds of G proteins of a specific subtype. The α-and/or A′-subunit of the G proteins activates the next target protein(s) to evoke further intracellular responses. Because all of several hundreds of members in the GPCR family appear to share a common motif in their transmembrane structure and a common topology, it is generally accepted that a similar switching mechanism functions in all of these receptors.

II. MC4-R

Melanocortin peptides or melanotropins, α-MSH (melanocortin stimulating hormone), β-MSH, γ-MSH and ACTH (adrenocorticotropic hormone), are involved in many physiological functions in vertebrates, mammals and in humans. They regulate skin pigmentation and steroid production, modulate immune responses and learning processes, influence energy balance, growth and regeneration of nerves, and several other functions as well.

Five human receptors are known which interact with melanotropins, hMC1-R to hMC5-R. The receptors are seven-helix transmembrane-spanning receptors and belong to the superfamily of GPCRs; their activation leads to elevation of cAMP. The melanocortin receptors 1, 3, 4 and 5 recognize α-MSH, β-MSH, γ-MSH, while melanocortin receptor 2 recognizes only ACTH (Hruby, V. J. et al. J. Med. Chem. 1995, 38(18), 3454).

Considerable attention has recently focused on melanocortin receptors 3 and 4 that are widely expressed in the central nervous system, and also on melanocortin receptor 5, found in the brain and in various peripheral tissues. The physiological role of hMC3-R and hMC5-R is not well defined, although hMC5-R has recently been implicated in control of lipid and pheromone production in exocrine glands (Caldwell, H. K. et al. Chemical Senses, 2002, 27(1), 91). Rapidly growing pharmacological and genetic evidence suggests that hMC4-R is involved in regulation of the energy balance and body weight in rodents. The role of MC4-R in regulation of food intake and body weight is supported by results obtained from agonist/antagonist administration in rats and from murine genetics (Fan, W. et al. Nature, 1997, 385, 165; Huszer, D. et al. Cell, 1997, 88, 131; Klebig, M. L. et al. Proc. Nat]. Acad. Sci. 1995, 92, 4728; Karbon, W. et al. Abstract from the Nineteenth Annual Winter Neuropeptide Conference, 1998; Seely, R. J. et al. Nature, 1997, 390, 349; Comuzzie, A. G. Nat. Gen. 1997, 15, 273; Chagnon, Y. C. et al. Mol. Med. 1997, 3, 663; Lee, F. et al. 1997, World Patent Publication WO 97/47316; Shutter, J. R. et al. Gen. & Dev. 1997, 11, 593). Intraventricular administration of the agonist MTII reduced food intake and conversely, the antagonist SHU9119 increased food intake and body weight. Mice genetically deficient in the melanocortin receptor 4 develop obesity. It could be anticipated therefore that compounds inhibiting MC4-R might be useful in the treatment of weight control. As such, agonists of MC4-R may be useful as therapeutic agents for the diagnosis, treatment or prevention of diseases and disorders mediated through the MC4 receptor, more particularly, disorders related to obesity of any cause in humans. Thus there is a need to provide for potent and selective agonists of the MC4 receptor.

III. Three-Dimensional Structural Information

The biological properties of a protein depend directly on the protein's three-dimensional (3D) conformation. In turn, the 3D conformation determines the activity of enzymes, the capacity and specificity of binding proteins, and the potential for small molecules to interact with the receptor. Models at the atomic level are needed to obtain insight into the mechanisms of MC4 receptor activation, and the source of interactions between specific ligands and MC4-R. Thus, there is a need for 3D structure models for the MC4 receptor.

SUMMARY OF THE INVENTION

The present invention attempts to address this need by providing a 3D structure of human MC4 receptor that is useful in identifying potent and selective agonists or antagonist of the MC4 receptor for the treatment of MC4-R mediated disorders.

One aspect of the invention provides for a method of identifying a drug candidate useful for the treatment of a melanocortin receptor-4 (MC4-R) mediated disorder comprising the steps of:

• • (a) using a three-dimensional (3D) structure of MC4-R according to Table 1;
  • (b) employing said 3D structure to design or select in silico said drug candidate.

Another aspect of the invention provides a G-protein-coupled receptor selected from the group consisting of the following (a) or (b):

• • (a) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates as shown in Table 1;
  • (b) a G protein-coupled receptor having three-dimensional structure II defined by derived coordinates from the atomic coordinates as shown in Table 1, wherein the mean residual of the discrepancies between the positions of the α carbon atoms in the amino acid residues of seven helix sites SEQ ID NOS: 2-8 of the three-dimensional structure I and the positions of the corresponding α carbon atoms in the amino acid residues of the corresponding seven helix sites of the three-dimensional structure II is 1.5 Å or less when an image of the three-dimensional structure I obtained by computer-processing the atomic coordinates of Table 1 and an image of the three-dimensional structure II obtained by computer-processing said derived coordinates are superimposed.

These and other objects, features, and advantages will become apparent to those of ordinary skill in the art from a reading of the following detailed description and the appended claims.

SEQUENCE LISTING DESCRIPTION

Each of the protein sequences in the sequence listing is shown in Table A.

	TABLE A
	Sequence		Position on
	Description	SEQ ID NO:	SEQ ID NO: 1
	MC4R1	1	—
	HI	2	41-70
	HII	3	78-107
	HIII	4	120-150
	HIV	5	163-186
	HV	6	189-217
	HVI	7	239-270
	HVII	8	282-305
	ECI	9	108-119
	ECII	10	187-188
	ECIII	11	271-281
	THI	12	41-55
	THII-ECI-THIII	13	93-134
	THIV-ECII-THV	14	172-203
	THVI-ECIII-	15	256-296
	THVII
	THII	16	93-107
	THIII	17	120-134
	THIV	18	172-186
	THV	19	189-203
	THVI	20	256-270
	THVII	21	282-296
	1The corresponding human MC4R accession number is P32245.

DETAILED DESCRIPTION OF THE INVENTION

I. 3D Coordinates of MC4-R

G protein-coupled receptors (GPCRs) function in a number of signaling pathways, converting a variety of external stimuli to activate multiple copies of G protein subtypes specific to the relevant G protein-coupled receptor. GPCRs, including MC4-R, share many structural features, including a bundle of seven transmembrane α-helices connected by six loops of varying lengths. In the present invention, in silico 3D coordinates of the transmembrane and extra-cellular regions of MC4-R are provided. These coordinates were obtained by homology from a model constructed for MC1-R utilizing experimental mutagenesis data, the 3D structure of bacterial rhodopsin and in-house SAR data. The extra-cellular loops were subsequently modeled employing molecular dynamics simulations (Colson, A. O.; Perlman, J. H.; Smolyar, A.; Gershengorn, M. C.; Osman, R. O. Biophys. J. 1998, 74, 1087). The helices in the model were later refined using the 3D coordinates of mammalian rhodopsin (Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C. A.; Motoshima, H.; Fox, B. A.; Trong, I. L.; Teller, D. C.; Okada, T.; Stenkamp, R. E.; Yamamoto, M.; Miyano, M. Science, 2000, 289, 739). Further refinement, such as the removal of kinks from helices II, IV and V, and coordinates modification in view of SAR data generated in-house, was also performed.

As a result of the above analysis, the 3D structure of human MC4-R can be obtained as 3D coordinates. The atomic coordinates obtained by the invention are shown in Table 1 below.

TABLE 1
ATOM	1	N	TYR	41	−42.17	22.835	20.182
ATOM	2	CA	TYR	41	−43.253	21.888	20.437
ATOM	3	C	TYR	41	−43.856	21.393	19.14
ATOM	4	O	TYR	41	−43.754	20.208	18.867
ATOM	5	CB	TYR	41	−44.313	22.54	21.358
ATOM	6	CG	TYR	41	−43.737	22.689	22.774
ATOM	7	CD1	TYR	41	−43.202	23.907	23.205
ATOM	8	CD2	TYR	41	−43.739	21.595	23.648
ATOM	9	CE1	TYR	41	−42.691	24.038	24.501
ATOM	10	CE2	TYR	41	−43.23	21.726	24.943
ATOM	11	CZ	TYR	41	−42.706	22.946	25.378
ATOM	12	OH	TYR	41	−42.207	23.048	26.68
ATOM	13	HB1	TYR	41	−44.611	23.522	20.96
ATOM	14	HB2	TYR	41	−45.214	21.912	21.399
ATOM	15	HD1	TYR	41	−43.178	24.76	22.534
ATOM	16	HD2	TYR	41	−44.134	20.638	23.325
ATOM	17	HE1	TYR	41	−42.285	24.993	24.816
ATOM	18	HE2	TYR	41	−43.24	20.876	25.618
ATOM	19	HH	TYR	41	−41.876	23.91	26.906
ATOM	20	H	TYR	41	−42.203	23.429	19.373
ATOM	21	H1	TYR	41	−41.443	22.948	20.861
ATOM	22	HA	TYR	41	−42.843	21.005	20.958
ATOM	23	N	GLU	42	−44.472	22.257	18.305
ATOM	24	CA	GLU	42	−44.935	21.79	16.998
ATOM	25	C	GLU	42	−43.783	21.145	16.259
ATOM	26	O	GLU	42	−43.969	20.094	15.666
ATOM	27	CB	GLU	42	−45.602	22.894	16.124
ATOM	28	CG	GLU	42	−44.637	23.977	15.562
ATOM	29	CD	GLU	42	−43.955	24.75	16.659
ATOM	30	OE1	GLU	42	−44.365	25.911	16.926
ATOM	31	OE2	GLU	42	−43.007	24.192	17.276
ATOM	32	HB2	GLU	42	−46.086	22.403	15.262
ATOM	33	HB1	GLU	42	−46.389	23.387	16.718
ATOM	34	HG2	GLU	42	−45.216	24.683	14.945
ATOM	35	HG1	GLU	42	−43.877	23.523	14.908
ATOM	36	H	GLU	42	−44.567	23.225	18.539
ATOM	37	HA	GLU	42	−45.699	21.017	17.187
ATOM	38	N	GLN	43	−42.572	21.748	16.3
ATOM	39	CA	GLN	43	−41.429	21.147	15.618
ATOM	40	C	GLN	43	−41.245	19.723	16.093
ATOM	41	O	GLN	43	−40.87	18.877	15.297
ATOM	42	CB	GLN	43	−40.102	21.913	15.874
ATOM	43	CG	GLN	43	−40.085	23.327	15.231
ATOM	44	CD	GLN	43	−38.717	23.949	15.392
ATOM	45	OE1	GLN	43	−38.551	24.823	16.227
ATOM	46	NE2	GLN	43	−37.703	23.519	14.612
ATOM	47	H	GLN	43	−42.444	22.597	16.819
ATOM	48	HB2	GLN	43	−39.274	21.323	15.446
ATOM	49	HB1	GLN	43	−39.931	22.001	16.96
ATOM	50	HG2	GLN	43	−40.838	23.981	15.697
ATOM	51	HG1	GLN	43	−40.318	23.26	14.157
ATOM	52	HE21	GLN	43	−37.835	22.806	13.924
ATOM	53	HE22	GLN	43	−36.797	23.929	14.726
ATOM	54	HA	GLN	43	−41.633	21.134	14.535
ATOM	55	N	LEU	44	−41.502	19.435	17.388
ATOM	56	CA	LEU	44	−41.408	18.058	17.854
ATOM	57	C	LEU	44	−42.62	17.319	17.333
ATOM	58	O	LEU	44	−42.44	16.318	16.661
ATOM	59	CB	LEU	44	−41.344	17.92	19.404
ATOM	60	CG	LEU	44	−39.97	18.31	20.029
ATOM	61	CD1	LEU	44	−39.547	19.769	19.703
ATOM	62	CD2	LEU	44	−40.023	18.112	21.571
ATOM	63	HB2	LEU	44	−42.144	18.513	19.872
ATOM	64	HB1	LEU	44	−41.533	16.862	19.653
ATOM	65	HG	LEU	44	−39.195	17.633	19.628
ATOM	66	HD13	LEU	44	−39.362	19.895	18.626
ATOM	67	HD12	LEU	44	−38.614	20.023	20.229
ATOM	68	HD11	LEU	44	−40.327	20.478	20.021
ATOM	69	HD23	LEU	44	−40.771	18.786	22.019
ATOM	70	HD22	LEU	44	−39.043	18.329	22.024
ATOM	71	HD21	LEU	44	−40.293	17.074	21.821
ATOM	72	H	LEU	44	−41.827	20.135	18.024
ATOM	73	HA	LEU	44	−40.501	17.582	17.443
ATOM	74	N	PHE	45	−43.86	17.772	17.63
ATOM	75	CA	PHE	45	−45.039	16.97	17.296
ATOM	76	C	PHE	45	−45.242	16.72	15.818
ATOM	77	O	PHE	45	−45.949	15.772	15.509
ATOM	78	CB	PHE	45	−46.344	17.575	17.882
ATOM	79	CG	PHE	45	−46.298	17.607	19.419
ATOM	80	CD1	PHE	45	−46.255	18.819	20.119
ATOM	81	CD2	PHE	45	−46.307	16.405	20.137
ATOM	82	CE1	PHE	45	−46.195	18.824	21.516
ATOM	83	CE2	PHE	45	−46.198	16.408	21.531
ATOM	84	CZ	PHE	45	−46.142	17.62	22.223
ATOM	85	HB2	PHE	45	−46.491	18.581	17.46
ATOM	86	HB1	PHE	45	−47.211	16.96	17.591
ATOM	87	HD1	PHE	45	−46.273	19.763	19.585
ATOM	88	HD2	PHE	45	−46.402	15.46	19.614
ATOM	89	HE1	PHE	45	−46.194	19.762	22.058
ATOM	90	HE2	PHE	45	−46.162	15.472	22.08
ATOM	91	HZ	PHE	45	−46.06	17.625	23.305
ATOM	92	H	PHE	45	−43.983	18.635	18.124
ATOM	93	HA	PHE	45	−44.89	15.978	17.751
ATOM	94	N	VAL	46	−44.667	17.501	14.876
ATOM	95	CA	VAL	46	−44.821	17.135	13.465
ATOM	96	C	VAL	46	−44.033	15.881	13.143
ATOM	97	O	VAL	46	−44.515	15.085	12.353
ATOM	98	CB	VAL	46	−44.469	18.245	12.427
ATOM	99	CG1	VAL	46	−45.406	19.476	12.578
ATOM	100	CG2	VAL	46	−42.974	18.672	12.461
ATOM	101	HA	VAL	46	−45.885	16.895	13.294
ATOM	102	HB	VAL	46	−44.655	17.825	11.421
ATOM	103	HG23	VAL	46	−42.711	19.115	13.429
ATOM	104	HG22	VAL	46	−42.778	19.423	11.68
ATOM	105	HG21	VAL	46	−42.311	17.814	12.275
ATOM	106	HG13	VAL	46	−46.459	19.175	12.47
ATOM	107	HG12	VAL	46	−45.184	20.225	11.802
ATOM	108	HG11	VAL	46	−45.282	19.95	13.56
ATOM	109	H	VAL	46	−44.118	18.299	15.134
ATOM	110	N	SER	47	−42.819	15.654	13.697
ATOM	111	CA	SER	47	−42.042	14.502	13.235
ATOM	112	C	SER	47	−42.762	13.186	13.482
ATOM	113	O	SER	47	−42.826	12.411	12.54
ATOM	114	CB	SER	47	−40.56	14.53	13.691
ATOM	115	OG	SER	47	−39.977	15.765	13.236
ATOM	116	HB2	SER	47	−40.467	14.466	14.783
ATOM	117	HB1	SER	47	−40.029	13.674	13.242
ATOM	118	HG	SER	47	−39.063	15.866	13.485
ATOM	119	H	SER	47	−42.42	16.274	14.377
ATOM	120	HA	SER	47	−41.97	14.618	12.139
ATOM	121	N	PRO	48	−43.35	12.858	14.662
ATOM	122	CA	PRO	48	−44.222	11.697	14.744
ATOM	123	C	PRO	48	−45.25	11.674	13.641
ATOM	124	O	PRO	48	−45.415	10.631	13.032
ATOM	125	CB	PRO	48	−44.891	11.917	16.125
ATOM	126	CG	PRO	48	−43.83	12.71	16.92
ATOM	127	CD	PRO	48	−43.219	13.657	15.864
ATOM	128	HD2	PRO	48	−43.838	14.551	15.761
ATOM	129	HB2	PRO	48	−45.786	12.554	16.032
ATOM	130	HB1	PRO	48	−45.186	10.97	16.603
ATOM	131	HG1	PRO	48	−44.244	13.25	17.787
ATOM	132	HG2	PRO	48	−43.053	12.016	17.274
ATOM	133	HD1	PRO	48	−42.189	13.913	16.139
ATOM	134	H5	PRO	48	−43.616	10.78	14.751
ATOM	135	N	GLU	49	−45.951	12.796	13.359
ATOM	136	CA	GLU	49	−46.976	12.762	12.316
ATOM	137	C	GLU	49	−46.335	12.373	11.005
ATOM	138	O	GLU	49	−46.871	11.531	10.301
ATOM	139	CB	GLU	49	−47.705	14.126	12.166
ATOM	140	CG	GLU	49	−48.833	14.069	11.103
ATOM	141	CD	GLU	49	−49.525	15.405	11.044
ATOM	142	OE1	GLU	49	−48.941	16.346	10.442
ATOM	143	OE2	GLU	49	−50.649	15.524	11.601
ATOM	144	HB2	GLU	49	−48.142	14.406	13.139
ATOM	145	HB1	GLU	49	−46.987	14.907	11.874
ATOM	146	HG2	GLU	49	−49.562	13.284	11.362
ATOM	147	HG1	GLU	49	−48.421	13.843	10.107
ATOM	148	H	GLU	49	−45.77	13.66	13.836
ATOM	149	HA	GLU	49	−47.723	12.001	12.595
ATOM	150	N	VAL	50	−45.171	12.965	10.663
ATOM	151	CA	VAL	50	−44.507	12.568	9.425
ATOM	152	C	VAL	50	−44.222	11.086	9.502
ATOM	153	O	VAL	50	−44.503	10.379	8.547
ATOM	154	CB	VAL	50	−43.196	13.363	9.148
ATOM	155	CG1	VAL	50	−42.425	12.757	7.941
ATOM	156	CG2	VAL	50	−43.501	14.864	8.876
ATOM	157	HB	VAL	50	−42.542	13.292	10.033
ATOM	158	HG23	VAL	50	−44.115	14.969	7.968
ATOM	159	HG22	VAL	50	−42.564	15.424	8.73
ATOM	160	HG21	VAL	50	−44.042	15.327	9.714
ATOM	161	HG13	VAL	50	−42.042	11.755	8.187
ATOM	162	HG12	VAL	50	−41.567	13.39	7.676
ATOM	163	HG11	VAL	50	−43.083	12.681	7.062
ATOM	164	H	VAL	50	−44.738	13.638	11.267
ATOM	165	HA	VAL	50	−45.201	12.743	8.586
ATOM	166	N	PHE	51	−43.667	10.577	10.624
ATOM	167	CA	PHE	51	−43.405	9.142	10.698
ATOM	168	C	PHE	51	−44.673	8.324	10.713
ATOM	169	O	PHE	51	−44.615	7.19	10.266
ATOM	170	CB	PHE	51	−42.547	8.75	11.925
ATOM	171	CG	PHE	51	−41.169	9.426	11.884
ATOM	172	CD1	PHE	51	−40.324	9.241	10.783
ATOM	173	CD2	PHE	51	−40.731	10.228	12.943
ATOM	174	CE1	PHE	51	−39.113	9.929	10.7
ATOM	175	CE2	PHE	51	−39.457	10.801	12.926
ATOM	176	CZ	PHE	51	−38.645	10.653	11.8
ATOM	177	HB2	PHE	51	−43.108	9.027	12.829
ATOM	178	HB1	PHE	51	−42.396	7.659	11.936
ATOM	179	HD1	PHE	51	−40.591	8.558	9.985
ATOM	180	HD2	PHE	51	−41.378	10.409	13.79
ATOM	181	HE1	PHE	51	−38.539	9.888	9.782
ATOM	182	HE2	PHE	51	−39.099	11.359	13.786
ATOM	183	HZ	PHE	51	−37.654	11.093	11.783
ATOM	184	H	PHE	51	−43.449	11.159	11.411
ATOM	185	HA	PHE	51	−42.871	8.853	9.782
ATOM	186	N	VAL	52	−45.827	8.832	11.193
ATOM	187	CA	VAL	52	−47.061	8.071	11.016
ATOM	188	C	VAL	52	−47.274	7.98	9.523
ATOM	189	O	VAL	52	−47.498	6.89	9.025
ATOM	190	CB	VAL	52	−48.298	8.695	11.73
ATOM	191	CG1	VAL	52	−49.616	7.991	11.297
ATOM	192	CG2	VAL	52	−48.154	8.599	13.275
ATOM	193	HB	VAL	52	−48.377	9.756	11.442
ATOM	194	HG23	VAL	52	−48.14	7.546	13.596
ATOM	195	HG22	VAL	52	−48.998	9.103	13.77
ATOM	196	HG21	VAL	52	−47.226	9.072	13.622
ATOM	197	HG13	VAL	52	−49.788	8.091	10.214
ATOM	198	HG12	VAL	52	−50.477	8.438	11.818
ATOM	199	HG11	VAL	52	−49.574	6.921	11.551
ATOM	200	H	VAL	52	−45.867	9.75	11.59
ATOM	201	HA	VAL	52	−46.92	7.051	11.412
ATOM	202	N	THR	53	−47.202	9.101	8.773
ATOM	203	CA	THR	53	−47.413	9.007	7.329
ATOM	204	C	THR	53	−46.41	8.068	6.693
ATOM	205	O	THR	53	−46.823	7.159	5.989
ATOM	206	CB	THR	53	−47.343	10.405	6.655
ATOM	207	OG1	THR	53	−48.317	11.241	7.307
ATOM	208	CG2	THR	53	−47.635	10.318	5.133
ATOM	209	HB	THR	53	−46.337	10.832	6.805
ATOM	210	HG22	THR	53	−47.6	11.323	4.684
ATOM	211	HG21	THR	53	−48.636	9.894	4.963
ATOM	212	HG23	THR	53	−46.891	9.687	4.623
ATOM	213	HG1	THR	53	−48.315	12.139	6.99
ATOM	214	H	THR	53	−47.019	9.999	9.184
ATOM	215	HA	THR	53	−48.429	8.612	7.165
ATOM	216	N	LEU	54	−45.09	8.268	6.915
ATOM	217	CA	LEU	54	−44.099	7.417	6.255
ATOM	218	C	LEU	54	−44.276	5.991	6.722
ATOM	219	O	LEU	54	−44.28	5.088	5.901
ATOM	220	CB	LEU	54	−42.621	7.828	6.522
ATOM	221	CG	LEU	54	−42.221	9.253	6.028
ATOM	222	CD1	LEU	54	−40.76	9.569	6.463
ATOM	223	CD2	LEU	54	−42.344	9.403	4.486
ATOM	224	H	LEU	54	−44.783	8.983	7.545
ATOM	225	HB2	LEU	54	−41.958	7.093	6.034
ATOM	226	HB1	LEU	54	−42.443	7.763	7.606
ATOM	227	HG	LEU	54	−42.878	10.003	6.494
ATOM	228	HD13	LEU	54	−40.654	9.497	7.556
ATOM	229	HD12	LEU	54	−40.473	10.588	6.161
ATOM	230	HD11	LEU	54	−40.062	8.859	5.995
ATOM	231	HD23	LEU	54	−41.768	8.614	3.981
ATOM	232	HD22	LEU	54	−41.951	10.38	4.162
ATOM	233	HD21	LEU	54	−43.393	9.347	4.159
ATOM	234	HA	LEU	54	−44.276	7.443	5.171
ATOM	235	N	GLY	55	−44.413	5.764	8.045
ATOM	236	CA	GLY	55	−44.529	4.401	8.552
ATOM	237	C	GLY	55	−45.79	3.727	8.067
ATOM	238	O	GLY	55	−45.753	2.548	7.748
ATOM	239	H	GLY	55	−44.433	6.52	8.7
ATOM	240	HA1	GLY	55	−43.638	3.836	8.241
ATOM	241	HA2	GLY	55	−44.562	4.392	9.653
ATOM	242	N	VAL	56	−46.932	4.448	8.021
ATOM	243	CA	VAL	56	−48.17	3.818	7.569
ATOM	244	C	VAL	56	−48.056	3.546	6.09
ATOM	245	O	VAL	56	−48.195	2.395	5.704
ATOM	246	CB	VAL	56	−49.441	4.659	7.896
ATOM	247	CG1	VAL	56	−50.691	4.127	7.14
ATOM	248	CG2	VAL	56	−49.712	4.647	9.427
ATOM	249	HB	VAL	56	−49.279	5.701	7.568
ATOM	250	HG23	VAL	56	−48.82	4.958	9.991
ATOM	251	HG22	VAL	56	−49.99	3.635	9.76
ATOM	252	HG21	VAL	56	−50.538	5.333	9.674
ATOM	253	HG13	VAL	56	−50.581	4.267	6.054
ATOM	254	HG12	VAL	56	−51.593	4.672	7.458
ATOM	255	HG11	VAL	56	−50.838	3.055	7.345
ATOM	256	H	VAL	56	−46.94	5.419	8.27
ATOM	257	HA	VAL	56	−48.285	2.848	8.081
ATOM	258	N	ILE	57	−47.809	4.566	5.235
ATOM	259	CA	ILE	57	−47.762	4.282	3.799
ATOM	260	C	ILE	57	−46.679	3.25	3.558
ATOM	261	O	ILE	57	−46.878	2.347	2.762
ATOM	262	CB	ILE	57	−47.659	5.553	2.898
ATOM	263	CG1	ILE	57	−48.193	5.264	1.462
ATOM	264	CG2	ILE	57	−46.205	6.084	2.85
ATOM	265	CD1	ILE	57	−48.135	6.485	0.506
ATOM	266	HB	ILE	57	−48.305	6.332	3.339
ATOM	267	HG23	ILE	57	−45.802	6.16	3.865
ATOM	268	HG22	ILE	57	−46.151	7.086	2.399
ATOM	269	HG21	ILE	57	−45.581	5.392	2.265
ATOM	270	HG12	ILE	57	−49.246	4.94	1.525
ATOM	271	HG11	ILE	57	−47.61	4.445	1.018
ATOM	272	HD13	ILE	57	−48.622	7.358	0.966
ATOM	273	HD12	ILE	57	−48.659	6.247	−0.434
ATOM	274	HD11	ILE	57	−47.097	6.744	0.249
ATOM	275	H	ILE	57	−47.648	5.5	5.565
ATOM	276	HA	ILE	57	−48.727	3.811	3.561
ATOM	277	N	SER	58	−45.528	3.327	4.266
ATOM	278	CA	SER	58	−44.539	2.262	4.143
ATOM	279	C	SER	58	−45.19	0.94	4.454
ATOM	280	O	SER	58	−44.97	−0.006	3.716
ATOM	281	CB	SER	58	−43.371	2.377	5.157
ATOM	282	OG	SER	58	−42.617	1.15	5.16
ATOM	283	HB2	SER	58	−42.738	3.238	4.897
ATOM	284	HB1	SER	58	−43.782	2.532	6.164
ATOM	285	H	SER	58	−45.352	4.067	4.917
ATOM	286	HG	SER	58	−41.933	1.11	5.82
ATOM	287	HA	SER	58	−44.133	2.249	3.116
ATOM	288	N	LEU	59	−45.967	0.824	5.552
ATOM	289	CA	LEU	59	−46.504	−0.486	5.894
ATOM	290	C	LEU	59	−47.42	−0.971	4.795
ATOM	291	O	LEU	59	−47.186	−2.067	4.308
ATOM	292	CB	LEU	59	−47.237	−0.499	7.264
ATOM	293	CG	LEU	59	−47.848	−1.883	7.645
ATOM	294	CD1	LEU	59	−46.777	−3.01	7.727
ATOM	295	CD2	LEU	59	−48.587	−1.765	9.007
ATOM	296	HB2	LEU	59	−46.526	−0.188	8.045
ATOM	297	HB1	LEU	59	−48.047	0.246	7.229
ATOM	298	HG	LEU	59	−48.594	−2.171	6.884
ATOM	299	HD13	LEU	59	−46.351	−3.238	6.74
ATOM	300	HD12	LEU	59	−47.229	−3.94	8.107
ATOM	301	HD11	LEU	59	−45.962	−2.717	8.406
ATOM	302	HD23	LEU	59	−47.878	−1.499	9.807
ATOM	303	HD22	LEU	59	−49.07	−2.718	9.272
ATOM	304	HD21	LEU	59	−49.367	−0.989	8.959
ATOM	305	H	LEU	59	−46.162	1.606	6.148
ATOM	306	HA	LEU	59	−45.636	−1.161	5.968
ATOM	307	N	LEU	60	−48.465	−0.206	4.385
ATOM	308	CA	LEU	60	−49.372	−0.745	3.368
ATOM	309	C	LEU	60	−48.66	−0.951	2.044
ATOM	310	O	LEU	60	−49.099	−1.81	1.296
ATOM	311	CB	LEU	60	−50.85	−0.238	3.235
ATOM	312	CG	LEU	60	−51.163	1.212	2.743
ATOM	313	CD1	LEU	60	−51.258	2.235	3.908
ATOM	314	CD2	LEU	60	−50.202	1.695	1.629
ATOM	315	HA	LEU	60	−49.565	−1.767	3.731
ATOM	316	HB2	LEU	60	−51.333	−0.918	2.509
ATOM	317	HB1	LEU	60	−51.364	−0.384	4.2
ATOM	318	HG	LEU	60	−52.176	1.202	2.297
ATOM	319	HD13	LEU	60	−52.069	1.964	4.602
ATOM	320	HD12	LEU	60	−51.46	3.247	3.523
ATOM	321	HD11	LEU	60	−50.325	2.26	4.475
ATOM	322	HD23	LEU	60	−49.205	1.839	2.054
ATOM	323	HD22	LEU	60	−50.54	2.656	1.212
ATOM	324	HD21	LEU	60	−50.149	0.962	0.809
ATOM	325	H	LEU	60	−48.608	0.713	4.752
ATOM	326	N	GLU	61	−47.568	−0.221	1.709
ATOM	327	CA	GLU	61	−46.854	−0.514	0.461
ATOM	328	C	GLU	61	−45.97	−1.726	0.658
ATOM	329	O	GLU	61	−46.066	−2.676	−0.103
ATOM	330	CB	GLU	61	−45.962	0.663	−0.025
ATOM	331	CG	GLU	61	−46.797	1.867	−0.529
ATOM	332	CD	GLU	61	−45.884	3.007	−0.902
ATOM	333	OE1	GLU	61	−45.245	3.584	0.02
ATOM	334	OE2	GLU	61	−45.795	3.334	−2.116
ATOM	335	HB2	GLU	61	−45.287	0.99	0.782
ATOM	336	HB1	GLU	61	−45.345	0.318	−0.868
ATOM	337	HG2	GLU	61	−47.488	2.194	0.257
ATOM	338	HG1	GLU	61	−47.399	1.571	−1.403
ATOM	339	H	GLU	61	−47.195	0.483	2.319
ATOM	340	HA	GLU	61	−47.573	−0.733	−0.346
ATOM	341	N	ASN	62	−45.084	−1.714	1.677
ATOM	342	CA	ASN	62	−44.163	−2.831	1.856
ATOM	343	C	ASN	62	−44.914	−4.129	2.032
ATOM	344	O	ASN	62	−44.55	−5.105	1.393
ATOM	345	CB	ASN	62	−43.175	−2.629	3.032
ATOM	346	CG	ASN	62	−42.154	−1.591	2.636
ATOM	347	OD1	ASN	62	−41.3	−1.919	1.831
ATOM	348	ND2	ASN	62	−42.193	−0.343	3.136
ATOM	349	H	ASN	62	−45.03	−0.94	2.306
ATOM	350	HB2	ASN	62	−42.631	−3.568	3.211
ATOM	351	HB1	ASN	62	−43.716	−2.366	3.954
ATOM	352	HD21	ASN	62	−42.892	−0.081	3.797
ATOM	353	HD22	ASN	62	−41.515	0.338	2.848
ATOM	354	HA	ASN	62	−43.555	−2.905	0.944
ATOM	355	N	ILE	63	−45.964	−4.176	2.886
ATOM	356	CA	ILE	63	−46.688	−5.438	3.043
ATOM	357	C	ILE	63	−47.291	−5.839	1.71
ATOM	358	O	ILE	63	−47.398	−7.022	1.434
ATOM	359	CB	ILE	63	−47.779	−5.424	4.159
ATOM	360	CG1	ILE	63	−48.151	−6.847	4.683
ATOM	361	CG2	ILE	63	−49.07	−4.729	3.646
ATOM	362	CD1	ILE	63	−47.034	−7.551	5.505
ATOM	363	HB	ILE	63	−47.385	−4.846	5.012
ATOM	364	HG23	ILE	63	−48.805	−3.806	3.124
ATOM	365	HG22	ILE	63	−49.742	−4.482	4.483
ATOM	366	HG21	ILE	63	−49.617	−5.373	2.94
ATOM	367	HG12	ILE	63	−48.445	−7.492	3.841
ATOM	368	HG11	ILE	63	−49.023	−6.75	5.352
ATOM	369	HD13	ILE	63	−46.171	−7.836	4.886
ATOM	370	HD12	ILE	63	−47.435	−8.474	5.952
ATOM	371	HD11	ILE	63	−46.689	−6.896	6.319
ATOM	372	H	ILE	63	−46.262	−3.363	3.395
ATOM	373	HA	ILE	63	−45.926	−6.162	3.349
ATOM	374	N	LEU	64	−47.706	−4.878	0.853
ATOM	375	CA	LEU	64	−48.315	−5.255	−0.42
ATOM	376	C	LEU	64	−47.241	−5.836	−1.305
ATOM	377	O	LEU	64	−47.408	−6.956	−1.764
ATOM	378	CB	LEU	64	−49.04	−4.035	−1.064
ATOM	379	CG	LEU	64	−49.834	−4.317	−2.379
ATOM	380	CD1	LEU	64	−50.78	−3.116	−2.673
ATOM	381	CD2	LEU	64	−48.913	−4.541	−3.614
ATOM	382	H	LEU	64	−47.585	−3.903	1.051
ATOM	383	HB2	LEU	64	−48.327	−3.218	−1.247
ATOM	384	HB1	LEU	64	−49.758	−3.689	−0.304
ATOM	385	HG	LEU	64	−50.462	−5.213	−2.236
ATOM	386	HD13	LEU	64	−51.483	−2.955	−1.84
ATOM	387	HD12	LEU	64	−51.374	−3.299	−3.582
ATOM	388	HD11	LEU	64	−50.193	−2.196	−2.817
ATOM	389	HD23	LEU	64	−48.186	−3.72	−3.709
ATOM	390	HD22	LEU	64	−49.512	−4.58	−4.537
ATOM	391	HD21	LEU	64	−48.367	−5.489	−3.552
ATOM	392	HA	LEU	64	−49.08	−6.028	−0.234
ATOM	393	N	VAL	65	−46.134	−5.109	−1.577
ATOM	394	CA	VAL	65	−45.175	−5.626	−2.554
ATOM	395	C	VAL	65	−44.603	−6.934	−2.058
ATOM	396	O	VAL	65	−44.466	−7.841	−2.862
ATOM	397	CB	VAL	65	−44.046	−4.652	−3.018
ATOM	398	CG1	VAL	65	−44.63	−3.301	−3.526
ATOM	399	CG2	VAL	65	−42.972	−4.415	−1.925
ATOM	400	HB	VAL	65	−43.522	−5.127	−3.867
ATOM	401	HG23	VAL	65	−43.46	−4.022	−1.03
ATOM	402	HG22	VAL	65	−42.219	−3.687	−2.266
ATOM	403	HG21	VAL	65	−42.449	−5.348	−1.664
ATOM	404	HG13	VAL	65	−45.368	−3.48	−4.323
ATOM	405	HG12	VAL	65	−43.832	−2.664	−3.935
ATOM	406	HG11	VAL	65	−45.119	−2.739	−2.719
ATOM	407	H	VAL	65	−45.974	−4.229	−1.124
ATOM	408	HA	VAL	65	−45.756	−5.85	−3.465
ATOM	409	N	ILE	66	−44.262	−7.086	−0.757
ATOM	410	CA	ILE	66	−43.693	−8.365	−0.322
ATOM	411	C	ILE	66	−44.707	−9.473	−0.507
ATOM	412	O	ILE	66	−44.314	−10.57	−0.873
ATOM	413	CB	ILE	66	−43.147	−8.35	1.139
ATOM	414	CG1	ILE	66	−42.135	−9.509	1.386
ATOM	415	CG2	ILE	66	−44.296	−8.394	2.178
ATOM	416	CD1	ILE	66	−41.508	−9.48	2.806
ATOM	417	HB	ILE	66	−42.604	−7.401	1.262
ATOM	418	HG23	ILE	66	−45.07	−7.688	1.876
ATOM	419	HG22	ILE	66	−43.95	−8.096	3.177
ATOM	420	HG21	ILE	66	−44.742	−9.398	2.239
ATOM	421	HG12	ILE	66	−41.318	−9.425	0.653
ATOM	422	HG11	ILE	66	−42.63	−10.481	1.231
ATOM	423	HD13	ILE	66	−41.065	−8.493	3.011
ATOM	424	HD12	ILE	66	−40.719	−10.243	2.883
ATOM	425	HD11	ILE	66	−42.256	−9.702	3.582
ATOM	426	H	ILE	66	−44.396	−6.345	−0.092
ATOM	427	HA	ILE	66	−42.836	−8.559	−0.986
ATOM	428	N	VAL	67	−46.017	−9.228	−0.266
ATOM	429	CA	VAL	67	−47.001	−10.296	−0.441
ATOM	430	C	VAL	67	−47.161	−10.562	−1.92
ATOM	431	O	VAL	67	−47.109	−11.715	−2.319
ATOM	432	CB	VAL	67	−48.367	−9.965	0.234
ATOM	433	CG1	VAL	67	−49.482	−10.95	−0.219
ATOM	434	CG2	VAL	67	−48.227	−10.017	1.782
ATOM	435	HB	VAL	67	−48.678	−8.95	−0.068
ATOM	436	HG23	VAL	67	−48.048	−11.051	2.118
ATOM	437	HG22	VAL	67	−49.147	−9.651	2.262
ATOM	438	HG21	VAL	67	−47.386	−9.401	2.129
ATOM	439	HG13	VAL	67	−49.685	−10.852	−1.297
ATOM	440	HG12	VAL	67	−50.419	−10.74	0.32
ATOM	441	HG11	VAL	67	−49.183	−11.989	−0.011
ATOM	442	H	VAL	67	−46.344	−8.313	−0.016
ATOM	443	HA	VAL	67	−46.622	−11.215	0.033
ATOM	444	N	ALA	68	−47.355	−9.519	−2.756
ATOM	445	CA	ALA	68	−47.473	−9.756	−4.195
ATOM	446	C	ALA	68	−46.252	−10.494	−4.698
ATOM	447	O	ALA	68	−46.393	−11.403	−5.501
ATOM	448	CB	ALA	68	−47.611	−8.425	−4.978
ATOM	449	HB3	ALA	68	−46.727	−7.791	−4.814
ATOM	450	HB2	ALA	68	−48.507	−7.881	−4.642
ATOM	451	HB1	ALA	68	−47.705	−8.626	−6.057
ATOM	452	H	ALA	68	−47.403	−8.581	−2.407
ATOM	453	HA	ALA	68	−48.369	−10.372	−4.378
ATOM	454	N	ILE	69	−45.042	−10.12	−4.229
ATOM	455	CA	ILE	69	−43.842	−10.86	−4.621
ATOM	456	C	ILE	69	−43.965	−12.281	−4.12
ATOM	457	O	ILE	69	−43.711	−13.201	−4.881
ATOM	458	CB	ILE	69	−42.542	−10.179	−4.088
ATOM	459	CG1	ILE	69	−42.269	−8.87	−4.896
ATOM	460	CG2	ILE	69	−41.342	−11.171	−4.125
ATOM	461	CD1	ILE	69	−41.234	−7.92	−4.231
ATOM	462	HB	ILE	69	−42.696	−9.921	−3.029
ATOM	463	HG23	ILE	69	−41.507	−12.015	−3.438
ATOM	464	HG22	ILE	69	−40.405	−10.691	−3.812
ATOM	465	HG21	ILE	69	−41.219	−11.578	−5.14
ATOM	466	HG12	ILE	69	−43.204	−8.297	−5
ATOM	467	HG11	ILE	69	−41.942	−9.125	−5.916
ATOM	468	HD13	ILE	69	−41.573	−7.632	−3.224
ATOM	469	HD12	ILE	69	−41.129	−7.005	−4.835
ATOM	470	HD11	ILE	69	−40.241	−8.383	−4.147
ATOM	471	H	ILE	69	−44.962	−9.366	−3.574
ATOM	472	HA	ILE	69	−43.786	−10.898	−5.722
ATOM	473	N	ALA	70	−44.34	−12.494	−2.84
ATOM	474	CA	ALA	70	−44.462	−13.862	−2.343
ATOM	475	C	ALA	70	−45.554	−14.568	−3.106
ATOM	476	O	ALA	70	−45.419	−15.731	−3.454
ATOM	477	CB	ALA	70	−44.796	−13.899	−0.83
ATOM	478	HB3	ALA	70	−45.775	−13.434	−0.645
ATOM	479	HB2	ALA	70	−44.028	−13.354	−0.258
ATOM	480	HB1	ALA	70	−44.831	−14.94	−0.473
ATOM	481	H	ALA	70	−44.549	−11.729	−2.226
ATOM	482	HA	ALA	70	−43.505	−14.387	−2.503
ATOM	483	H3	ALA	70	−46.477	−14.041	−3.346
ATOM	484	N	PRO	78	−33.837	−12.212	−9.397
ATOM	485	CA	PRO	78	−33.141	−11.409	−8.403
ATOM	486	C	PRO	78	−33.859	−10.111	−8.114
ATOM	487	O	PRO	78	−33.965	−9.749	−6.953
ATOM	488	CB	PRO	78	−31.767	−11.25	−9.101
ATOM	489	CG	PRO	78	−31.646	−12.521	−9.975
ATOM	490	CD	PRO	78	−33.077	−12.717	−10.526
ATOM	491	HB2	PRO	78	−30.936	−11.173	−8.383
ATOM	492	HB1	PRO	78	−31.766	−10.363	−9.755
ATOM	493	HG1	PRO	78	−30.886	−12.429	−10.768
ATOM	494	HG2	PRO	78	−31.388	−13.377	−9.328
ATOM	495	HD1	PRO	78	−33.256	−12.082	−11.409
ATOM	496	HD2	PRO	78	−33.302	−13.769	−10.766
ATOM	497	HA	PRO	78	−33.022	−11.995	−7.481
ATOM	498	H4	PRO	78	−34.819	−12.399	−9.314
ATOM	499	N	MET	79	−34.364	−9.422	−9.166
ATOM	500	CA	MET	79	−35.055	−8.143	−8.98
ATOM	501	C	MET	79	−35.919	−8.151	−7.737
ATOM	502	O	MET	79	−35.828	−7.249	−6.92
ATOM	503	CB	MET	79	−35.946	−7.79	−10.206
ATOM	504	CG	MET	79	−36.547	−6.361	−10.116
ATOM	505	SD	MET	79	−35.217	−5.12	−10.308
ATOM	506	CE	MET	79	−35.374	−4.149	−8.776
ATOM	507	HB2	MET	79	−35.348	−7.849	−11.13
ATOM	508	HB1	MET	79	−36.76	−8.528	−10.288
ATOM	509	HG2	MET	79	−37.091	−6.211	−9.172
ATOM	510	HG1	MET	79	−37.258	−6.214	−10.943
ATOM	511	HE3	MET	79	−35.292	−4.806	−7.897
ATOM	512	HE2	MET	79	−36.347	−3.636	−8.766
ATOM	513	HE1	MET	79	−34.571	−3.399	−8.738
ATOM	514	H	MET	79	−34.233	−9.764	−10.098
ATOM	515	HA	MET	79	−34.293	−7.358	−8.907
ATOM	516	LPD2	MET	79	−35.319	−4.733	−10.856
ATOM	517	LPD1	MET	79	−34.608	−5.417	−10.35
ATOM	518	N	TYR	80	−36.778	−9.182	−7.591
ATOM	519	CA	TYR	80	−37.722	−9.207	−6.475
ATOM	520	C	TYR	80	−37.081	−9.696	−5.196
ATOM	521	O	TYR	80	−37.416	−9.191	−4.135
ATOM	522	CB	TYR	80	−38.919	−10.122	−6.84
ATOM	523	CG	TYR	80	−39.509	−9.875	−8.241
ATOM	524	CD1	TYR	80	−39.392	−8.649	−8.908
ATOM	525	CD2	TYR	80	−40.182	−10.924	−8.878
ATOM	526	CE1	TYR	80	−39.818	−8.517	−10.233
ATOM	527	CE2	TYR	80	−40.652	−10.779	−10.187
ATOM	528	CZ	TYR	80	−40.458	−9.581	−10.879
ATOM	529	OH	TYR	80	−40.907	−9.473	−12.198
ATOM	530	HB1	TYR	80	−38.579	−11.168	−6.78
ATOM	531	HB2	TYR	80	−39.712	−9.975	−6.101
ATOM	532	HD1	TYR	80	−38.972	−7.782	−8.413
ATOM	533	HD2	TYR	80	−40.346	−11.863	−8.359
ATOM	534	HE1	TYR	80	−39.649	−7.582	−10.756
ATOM	535	HE2	TYR	80	−41.17	−11.599	−10.672
ATOM	536	HH	TYR	80	−40.8	−8.61	−12.582
ATOM	537	H	TYR	80	−36.779	−9.942	−8.244
ATOM	538	HA	TYR	80	−38.11	−8.196	−6.279
ATOM	539	N	PHE	81	−36.159	−10.681	−5.26
ATOM	540	CA	PHE	81	−35.525	−11.163	−4.034
ATOM	541	C	PHE	81	−34.827	−10.021	−3.335
ATOM	542	O	PHE	81	−34.84	−9.988	−2.114
ATOM	543	CB	PHE	81	−34.494	−12.291	−4.296
ATOM	544	CG	PHE	81	−35.217	−13.585	−4.701
ATOM	545	CD1	PHE	81	−35.677	−14.46	−3.709
ATOM	546	CD2	PHE	81	−35.425	−13.911	−6.046
ATOM	547	CE1	PHE	81	−36.322	−15.65	−4.056
ATOM	548	CE2	PHE	81	−36.074	−15.098	−6.396
ATOM	549	CZ	PHE	81	−36.521	−15.972	−5.401
ATOM	550	HB2	PHE	81	−33.776	−11.976	−5.069
ATOM	551	HB1	PHE	81	−33.92	−12.483	−3.375
ATOM	552	HD1	PHE	81	−35.535	−14.218	−2.66
ATOM	553	HD2	PHE	81	−35.086	−13.247	−6.831
ATOM	554	HE1	PHE	81	−36.67	−16.325	−3.28
ATOM	555	HE2	PHE	81	−36.23	−15.343	−7.443
ATOM	556	HZ	PHE	81	−37.02	−16.897	−5.672
ATOM	557	H	PHE	81	−35.88	−11.065	−6.139
ATOM	558	HA	PHE	81	−36.307	−11.551	−3.36
ATOM	559	N	PHE	82	−34.212	−9.066	−4.066
ATOM	560	CA	PHE	82	−33.611	−7.936	−3.363
ATOM	561	C	PHE	82	−34.71	−7.205	−2.618
ATOM	562	O	PHE	82	−34.586	−6.972	−1.425
ATOM	563	CB	PHE	82	−32.907	−6.914	−4.297
ATOM	564	CG	PHE	82	−32.079	−7.58	−5.406
ATOM	565	CD1	PHE	82	−31.01	−8.427	−5.096
ATOM	566	CD2	PHE	82	−32.386	−7.332	−6.748
ATOM	567	CE1	PHE	82	−30.215	−8.958	−6.117
ATOM	568	CE2	PHE	82	−31.606	−7.878	−7.772
ATOM	569	CZ	PHE	82	−30.488	−8.648	−7.452
ATOM	570	HB2	PHE	82	−33.654	−6.246	−4.754
ATOM	571	HB1	PHE	82	−32.239	−6.28	−3.699
ATOM	572	HD1	PHE	82	−30.791	−8.667	−4.061
ATOM	573	HD2	PHE	82	−33.225	−6.697	−6.996
ATOM	574	HE1	PHE	82	−29.381	−9.61	−5.884
ATOM	575	HE2	PHE	82	−31.855	−7.7	−8.813
ATOM	576	HZ	PHE	82	−29.832	−9.002	−8.24
ATOM	577	H	PHE	82	−34.188	−9.103	−5.07
ATOM	578	HA	PHE	82	−32.872	−8.328	−2.643
ATOM	579	N	ILE	83	−35.799	−6.84	−3.334
ATOM	580	CA	ILE	83	−36.863	−6.042	−2.72
ATOM	581	C	ILE	83	−37.411	−6.766	−1.519
ATOM	582	O	ILE	83	−37.676	−6.114	−0.521
ATOM	583	CB	ILE	83	−37.99	−5.707	−3.74
ATOM	584	CG1	ILE	83	−37.441	−4.727	−4.824
ATOM	585	CG2	ILE	83	−39.241	−5.109	−3.028
ATOM	586	CD1	ILE	83	−38.196	−4.868	−6.168
ATOM	587	HB	ILE	83	−38.295	−6.651	−4.218
ATOM	588	HG23	ILE	83	−39.703	−5.846	−2.353
ATOM	589	HG22	ILE	83	−40.01	−4.801	−3.751
ATOM	590	HG21	ILE	83	−38.956	−4.227	−2.433
ATOM	591	HG12	ILE	83	−36.375	−4.905	−5.039
ATOM	592	HG11	ILE	83	−37.526	−3.691	−4.454
ATOM	593	HD13	ILE	83	−37.952	−5.818	−6.661
ATOM	594	HD12	ILE	83	−37.913	−4.05	−6.844
ATOM	595	HD11	ILE	83	−39.278	−4.847	−6
ATOM	596	H	ILE	83	−35.895	−7.125	−4.291
ATOM	597	HA	ILE	83	−36.442	−5.088	−2.37
ATOM	598	N	CYS	84	−37.585	−8.103	−1.579
ATOM	599	CA	CYS	84	−38.047	−8.82	−0.393
ATOM	600	C	CYS	84	−37.251	−8.385	0.818
ATOM	601	O	CYS	84	−37.838	−8.124	1.856
ATOM	602	CB	CYS	84	−37.897	−10.354	−0.577
ATOM	603	SG	CYS	84	−38.424	−11.251	0.92
ATOM	604	HG	CYS	84	−39.408	−11.045	0.873
ATOM	605	HB2	CYS	84	−38.489	−10.699	−1.441
ATOM	606	HB1	CYS	84	−36.843	−10.613	−0.75
ATOM	607	H	CYS	84	−37.398	−8.611	−2.425
ATOM	608	HA	CYS	84	−39.11	−8.575	−0.236
ATOM	609	LPG2	CYS	84	−38.137	−11.002	1.482
ATOM	610	LPG1	CYS	84	−38.299	−11.917	0.877
ATOM	611	N	SER	85	−35.907	−8.29	0.709
ATOM	612	CA	SER	85	−35.119	−7.908	1.88
ATOM	613	C	SER	85	−35.411	−6.49	2.306
ATOM	614	O	SER	85	−35.574	−6.249	3.493
ATOM	615	CB	SER	85	−33.593	−8.008	1.637
ATOM	616	OG	SER	85	−32.933	−7.864	2.909
ATOM	617	HB2	SER	85	−33.37	−8.989	1.193
ATOM	618	HB1	SER	85	−33.265	−7.226	0.932
ATOM	619	HG	SER	85	−31.985	−7.94	2.867
ATOM	620	H	SER	85	−35.439	−8.464	−0.162
ATOM	621	HA	SER	85	−35.37	−8.597	2.703
ATOM	622	N	LEU	86	−35.472	−5.523	1.361
ATOM	623	CA	LEU	86	−35.716	−4.145	1.78
ATOM	624	C	LEU	86	−37.088	−4.109	2.401
ATOM	625	O	LEU	86	−37.228	−3.573	3.486
ATOM	626	CB	LEU	86	−35.616	−3.063	0.663
ATOM	627	CG	LEU	86	−34.21	−2.886	−0.011
ATOM	628	CD1	LEU	86	−33.049	−3.479	0.832
ATOM	629	CD2	LEU	86	−34.154	−3.446	−1.46
ATOM	630	H	LEU	86	−35.384	−5.733	0.385
ATOM	631	HB2	LEU	86	−35.889	−2.108	1.146
ATOM	632	HB1	LEU	86	−36.384	−3.265	−0.1
ATOM	633	HG	LEU	86	−34.015	−1.802	−0.122
ATOM	634	HD13	LEU	86	−32.942	−2.924	1.776
ATOM	635	HD12	LEU	86	−32.108	−3.405	0.281
ATOM	636	HD11	LEU	86	−33.193	−4.547	1.042
ATOM	637	HD23	LEU	86	−34.248	−4.536	−1.448
ATOM	638	HD22	LEU	86	−33.195	−3.192	−1.939
ATOM	639	HD21	LEU	86	−34.96	−3.018	−2.077
ATOM	640	HA	LEU	86	−35.007	−3.883	2.583
ATOM	641	N	ALA	87	−38.117	−4.686	1.747
ATOM	642	CA	ALA	87	−39.446	−4.651	2.343
ATOM	643	C	ALA	87	−39.414	−5.168	3.762
ATOM	644	O	ALA	87	−40.043	−4.573	4.624
ATOM	645	CB	ALA	87	−40.469	−5.454	1.502
ATOM	646	H	ALA	87	−37.986	−5.126	0.857
ATOM	647	HB3	ALA	87	−40.16	−6.509	1.44
ATOM	648	HB2	ALA	87	−40.535	−5.042	0.483
ATOM	649	HB1	ALA	87	−41.461	−5.394	1.972
ATOM	650	HA	ALA	87	−39.75	−3.597	2.379
ATOM	651	N	VAL	88	−38.673	−6.263	4.042
ATOM	652	CA	VAL	88	−38.544	−6.694	5.433
ATOM	653	C	VAL	88	−37.944	−5.557	6.232
ATOM	654	O	VAL	88	−38.558	−5.119	7.193
ATOM	655	CB	VAL	88	−37.709	−8.003	5.593
ATOM	656	CG1	VAL	88	−37.317	−8.261	7.075
ATOM	657	CG2	VAL	88	−38.488	−9.228	5.04
ATOM	658	H	VAL	88	−38.17	−6.746	3.319
ATOM	659	HB	VAL	88	−36.775	−7.902	5.018
ATOM	660	HG13	VAL	88	−36.638	−7.478	7.444
ATOM	661	HG12	VAL	88	−36.794	−9.225	7.174
ATOM	662	HG11	VAL	88	−38.216	−8.281	7.709
ATOM	663	HG23	VAL	88	−39.413	−9.392	5.613
ATOM	664	HG22	VAL	88	−37.872	−10.139	5.103
ATOM	665	HG21	VAL	88	−38.754	−9.075	3.987
ATOM	666	HA	VAL	88	−39.55	−6.889	5.836
ATOM	667	N	ALA	89	−36.742	−5.064	5.86
ATOM	668	CA	ALA	89	−36.092	−4.045	6.686
ATOM	669	C	ALA	89	−37.002	−2.856	6.903
ATOM	670	O	ALA	89	−37.153	−2.394	8.023
ATOM	671	CB	ALA	89	−34.775	−3.527	6.051
ATOM	672	H	ALA	89	−36.28	−5.396	5.033
ATOM	673	HB3	ALA	89	−34.972	−3.001	5.105
ATOM	674	HB2	ALA	89	−34.076	−4.352	5.85
ATOM	675	HB1	ALA	89	−34.292	−2.831	6.751
ATOM	676	HA	ALA	89	−35.853	−4.5	7.663
ATOM	677	N	ASP	90	−37.617	−2.338	5.821
ATOM	678	CA	ASP	90	−38.45	−1.149	5.947
ATOM	679	C	ASP	90	−39.619	−1.393	6.873
ATOM	680	O	ASP	90	−39.984	−0.489	7.611
ATOM	681	CB	ASP	90	−38.935	−0.665	4.559
ATOM	682	CG	ASP	90	−37.751	−0.248	3.721
ATOM	683	OD1	ASP	90	−36.814	0.397	4.273
ATOM	684	OD2	ASP	90	−37.747	−0.552	2.5
ATOM	685	H	ASP	90	−37.494	−2.745	4.916
ATOM	686	HB2	ASP	90	−39.606	0.196	4.683
ATOM	687	HB1	ASP	90	−39.496	−1.472	4.061
ATOM	688	HA	ASP	90	−37.826	−0.357	6.386
ATOM	689	N	MET	91	−40.232	−2.597	6.888
ATOM	690	CA	MET	91	−41.268	−2.836	7.893
ATOM	691	C	MET	91	−40.644	−2.752	9.27
ATOM	692	O	MET	91	−41.261	−2.169	10.15
ATOM	693	CB	MET	91	−42.014	−4.186	7.714
ATOM	694	CG	MET	91	−42.911	−4.158	6.449
ATOM	695	SD	MET	91	−43.91	−5.673	6.273
ATOM	696	CE	MET	91	−42.665	−6.903	5.773
ATOM	697	HB2	MET	91	−41.275	−5	7.663
ATOM	698	HB1	MET	91	−42.661	−4.36	8.59
ATOM	699	HG2	MET	91	−42.299	−4.022	5.55
ATOM	700	HG1	MET	91	−43.626	−3.322	6.51
ATOM	701	HE3	MET	91	−42.133	−6.561	4.873
ATOM	702	HE2	MET	91	−43.176	−7.852	5.556
ATOM	703	HE1	MET	91	−41.949	−7.071	6.589
ATOM	704	H	MET	91	−39.948	−3.341	6.275
ATOM	705	HA	MET	91	−42.017	−2.03	7.819
ATOM	706	LPD2	MET	91	−44.388	−5.599	5.796
ATOM	707	LPD1	MET	91	−44.203	−5.844	6.861
ATOM	708	N	LEU	92	−39.426	−3.302	9.493
ATOM	709	CA	LEU	92	−38.814	−3.158	10.815
ATOM	710	C	LEU	92	−38.649	−1.686	11.123
ATOM	711	O	LEU	92	−38.999	−1.285	12.223
ATOM	712	CB	LEU	92	−37.432	−3.848	11.023
ATOM	713	CG	LEU	92	−37.461	−5.38	11.325
ATOM	714	CD1	LEU	92	−38.152	−5.731	12.675
ATOM	715	CD2	LEU	92	−38.086	−6.199	10.168
ATOM	716	HB2	LEU	92	−36.799	−3.658	10.143
ATOM	717	HB1	LEU	92	−36.93	−3.374	11.884
ATOM	718	HG	LEU	92	−36.407	−5.7	11.419
ATOM	719	HD13	LEU	92	−37.756	−5.103	13.488
ATOM	720	HD12	LEU	92	−37.957	−6.784	12.931
ATOM	721	HD11	LEU	92	−39.242	−5.6	12.626
ATOM	722	HD23	LEU	92	−39.143	−5.935	10.018
ATOM	723	HD22	LEU	92	−38.024	−7.278	10.38
ATOM	724	HD21	LEU	92	−37.525	−5.999	9.245
ATOM	725	H	LEU	92	−38.919	−3.766	8.762
ATOM	726	HA	LEU	92	−39.514	−3.564	11.556
ATOM	727	N	VAL	93	−38.114	−0.85	10.202
ATOM	728	CA	VAL	93	−37.909	0.553	10.57
ATOM	729	C	VAL	93	−39.249	1.2	10.828
ATOM	730	O	VAL	93	−39.346	2.002	11.743
ATOM	731	CB	VAL	93	−37.081	1.467	9.612
ATOM	732	CG1	VAL	93	−35.832	0.749	9.032
ATOM	733	CG2	VAL	93	−37.899	2.141	8.476
ATOM	734	HB	VAL	93	−36.734	2.31	10.235
ATOM	735	HG23	VAL	93	−38.381	1.392	7.842
ATOM	736	HG22	VAL	93	−37.23	2.748	7.846
ATOM	737	HG21	VAL	93	−38.676	2.81	8.879
ATOM	738	HG13	VAL	93	−35.241	0.288	9.838
ATOM	739	HG12	VAL	93	−35.201	1.473	8.495
ATOM	740	HG11	VAL	93	−36.115	−0.026	8.309
ATOM	741	H	VAL	93	−37.875	−1.18	9.287
ATOM	742	HA	VAL	93	−37.351	0.53	11.524
ATOM	743	N	SER	94	−40.291	0.884	10.028
ATOM	744	CA	SER	94	−41.583	1.531	10.24
ATOM	745	C	SER	94	−42.072	1.28	11.646
ATOM	746	O	SER	94	−42.377	2.231	12.351
ATOM	747	CB	SER	94	−42.663	1.027	9.248
ATOM	748	OG	SER	94	−43.925	1.635	9.571
ATOM	749	HB2	SER	94	−42.356	1.295	8.225
ATOM	750	HB1	SER	94	−42.755	−0.069	9.31
ATOM	751	HG	SER	94	−44.624	1.382	8.973
ATOM	752	H	SER	94	−40.193	0.225	9.277
ATOM	753	HA	SER	94	−41.466	2.618	10.092
ATOM	754	N	VAL	95	−42.16	0.003	12.08
ATOM	755	CA	VAL	95	−42.695	−0.26	13.415
ATOM	756	C	VAL	95	−41.69	0.156	14.465
ATOM	757	O	VAL	95	−42.096	0.674	15.492
ATOM	758	CB	VAL	95	−43.164	−1.73	13.648
ATOM	759	CG1	VAL	95	−44.211	−2.156	12.58
ATOM	760	CG2	VAL	95	−41.993	−2.75	13.703
ATOM	761	HB	VAL	95	−43.661	−1.764	14.635
ATOM	762	HG23	VAL	95	−41.441	−2.757	12.756
ATOM	763	HG22	VAL	95	−42.381	−3.764	13.881
ATOM	764	HG21	VAL	95	−41.292	−2.511	14.518
ATOM	765	HG13	VAL	95	−45.047	−1.44	12.552
ATOM	766	HG12	VAL	95	−44.619	−3.15	12.821
ATOM	767	HG11	VAL	95	−43.762	−2.205	11.576
ATOM	768	H	VAL	95	−41.837	−0.755	11.509
ATOM	769	HA	VAL	95	−43.589	0.373	13.551
ATOM	770	N	SER	96	−40.373	−0.058	14.247
ATOM	771	CA	SER	96	−39.407	0.282	15.29
ATOM	772	C	SER	96	−39.38	1.784	15.473
ATOM	773	O	SER	96	−39.432	2.25	16.601
ATOM	774	CB	SER	96	−38.001	−0.294	14.976
ATOM	775	OG	SER	96	−37.168	−0.212	16.146
ATOM	776	HB2	SER	96	−38.11	−1.357	14.698
ATOM	777	HB1	SER	96	−37.55	0.251	14.13
ATOM	778	H	SER	96	−40.043	−0.446	13.383
ATOM	779	HG	SER	96	−36.31	−0.604	16.014
ATOM	780	HA	SER	96	−39.736	−0.185	16.233
ATOM	781	N	ASN	97	−39.32	2.575	14.376
ATOM	782	CA	ASN	97	−39.408	4.024	14.535
ATOM	783	C	ASN	97	−40.755	4.367	15.121
ATOM	784	O	ASN	97	−40.816	5.168	16.041
ATOM	785	CB	ASN	97	−39.226	4.842	13.229
ATOM	786	CG	ASN	97	−39.317	6.316	13.555
ATOM	787	OD1	ASN	97	−40.287	6.943	13.165
ATOM	788	ND2	ASN	97	−38.346	6.913	14.279
ATOM	789	HB2	ASN	97	−38.256	4.627	12.758
ATOM	790	HB1	ASN	97	−40.013	4.567	12.51
ATOM	791	H	ASN	97	−39.268	2.191	13.454
ATOM	792	HD21	ASN	97	−37.532	6.427	14.606
ATOM	793	HD22	ASN	97	−38.441	7.882	14.51
ATOM	794	HA	ASN	97	−38.627	4.321	15.244
ATOM	795	N	GLY	98	−41.85	3.763	14.606
ATOM	796	CA	GLY	98	−43.159	4.014	15.199
ATOM	797	C	GLY	98	−43.072	3.881	16.7
ATOM	798	O	GLY	98	−43.556	4.746	17.414
ATOM	799	H	GLY	98	−41.79	3.131	13.827
ATOM	800	HA1	GLY	98	−43.506	5.017	14.91
ATOM	801	HA2	GLY	98	−43.899	3.28	14.843
ATOM	802	N	SER	99	−42.445	2.787	17.187
ATOM	803	CA	SER	99	−42.331	2.585	18.627
ATOM	804	C	SER	99	−41.489	3.659	19.275
ATOM	805	O	SER	99	−41.962	4.246	20.236
ATOM	806	CB	SER	99	−41.737	1.194	18.968
ATOM	807	OG	SER	99	−42.585	0.178	18.402
ATOM	808	HB2	SER	99	−40.718	1.111	18.555
ATOM	809	HB1	SER	99	−41.684	1.074	20.064
ATOM	810	HG	SER	99	−42.266	−0.705	18.56
ATOM	811	H	SER	99	−42.06	2.092	16.574
ATOM	812	HA	SER	99	−43.347	2.612	19.056
ATOM	813	N	GLU	100	−40.247	3.945	18.809
ATOM	814	CA	GLU	100	−39.453	4.944	19.528
ATOM	815	C	GLU	100	−40.239	6.225	19.573
ATOM	816	O	GLU	100	−40.312	6.852	20.617
ATOM	817	CB	GLU	100	−38.023	5.267	18.981
ATOM	818	CG	GLU	100	−37.982	6.264	17.783
ATOM	819	CD	GLU	100	−36.606	6.588	17.259
ATOM	820	OE1	GLU	100	−36.338	6.395	16.039
ATOM	821	OE2	GLU	100	−35.763	7.076	18.056
ATOM	822	HB2	GLU	100	−37.435	5.735	19.789
ATOM	823	HB1	GLU	100	−37.535	4.315	18.729
ATOM	824	HG2	GLU	100	−38.392	7.242	18.076
ATOM	825	HG1	GLU	100	−38.586	5.87	16.961
ATOM	826	H	GLU	100	−39.863	3.491	18
ATOM	827	HA	GLU	100	−39.331	4.565	20.558
ATOM	828	N	THR	101	−40.82	6.652	18.432
ATOM	829	CA	THR	101	−41.318	8.016	18.383
ATOM	830	C	THR	101	−42.566	8.121	19.218
ATOM	831	O	THR	101	−42.621	9.022	20.036
ATOM	832	CB	THR	101	−41.447	8.577	16.94
ATOM	833	OG1	THR	101	−41.47	10.013	17.031
ATOM	834	CG2	THR	101	−42.709	8.073	16.196
ATOM	835	H	THR	101	−40.875	6.081	17.609
ATOM	836	HB	THR	101	−40.544	8.269	16.381
ATOM	837	HG1	THR	101	−41.45	10.443	16.184
ATOM	838	HG22	THR	101	−43.621	8.457	16.676
ATOM	839	HG21	THR	101	−42.739	6.977	16.183
ATOM	840	HG23	THR	101	−42.689	8.422	15.155
ATOM	841	HA	THR	101	−40.55	8.658	18.851
ATOM	842	N	ILE	102	−43.584	7.242	19.076
ATOM	843	CA	ILE	102	−44.815	7.47	19.839
ATOM	844	C	ILE	102	−44.564	7.353	21.33
ATOM	845	O	ILE	102	−45.221	8.054	22.083
ATOM	846	CB	ILE	102	−46.018	6.623	19.325
ATOM	847	CG1	ILE	102	−47.404	7.156	19.811
ATOM	848	CG2	ILE	102	−45.879	5.13	19.731
ATOM	849	CD1	ILE	102	−47.766	8.587	19.322
ATOM	850	HB	ILE	102	−46.004	6.68	18.222
ATOM	851	HG23	ILE	102	−44.861	4.75	19.57
ATOM	852	HG22	ILE	102	−46.576	4.507	19.149
ATOM	853	HG21	ILE	102	−46.127	5.013	20.792
ATOM	854	HG12	ILE	102	−47.455	7.134	20.912
ATOM	855	HG11	ILE	102	−48.181	6.473	19.425
ATOM	856	HD13	ILE	102	−47.19	9.363	19.848
ATOM	857	HD12	ILE	102	−48.832	8.786	19.519
ATOM	858	HD11	ILE	102	−47.591	8.682	18.239
ATOM	859	H	ILE	102	−43.512	6.452	18.463
ATOM	860	HA	ILE	102	−45.07	8.52	19.648
ATOM	861	N	ILE	103	−43.613	6.506	21.792
ATOM	862	CA	ILE	103	−43.261	6.509	23.218
ATOM	863	C	ILE	103	−42.531	7.801	23.532
ATOM	864	O	ILE	103	−42.927	8.497	24.454
ATOM	865	CB	ILE	103	−42.406	5.264	23.637
ATOM	866	CG1	ILE	103	−43.278	4.005	23.938
ATOM	867	CG2	ILE	103	−41.533	5.546	24.896
ATOM	868	CD1	ILE	103	−44.298	3.652	22.828
ATOM	869	HB	ILE	103	−41.701	5.025	22.822
ATOM	870	HG23	ILE	103	−40.79	6.331	24.702
ATOM	871	HG22	ILE	103	−40.981	4.642	25.197
ATOM	872	HG21	ILE	103	−42.169	5.86	25.737
ATOM	873	HG12	ILE	103	−43.838	4.159	24.876
ATOM	874	HG11	ILE	103	−42.614	3.135	24.081
ATOM	875	HD13	ILE	103	−45.065	4.435	22.773
ATOM	876	HD12	ILE	103	−44.801	2.701	23.064
ATOM	877	HD11	ILE	103	−43.803	3.55	21.852
ATOM	878	H	ILE	103	−43.088	5.934	21.157
ATOM	879	HA	ILE	103	−44.177	6.507	23.832
ATOM	880	N	ILE	104	−41.447	8.137	22.798
ATOM	881	CA	ILE	104	−40.656	9.323	23.146
ATOM	882	C	ILE	104	−41.452	10.603	22.968
ATOM	883	O	ILE	104	−41.164	11.581	23.641
ATOM	884	CB	ILE	104	−39.288	9.337	22.395
ATOM	885	CG1	ILE	104	−38.375	8.124	22.785
ATOM	886	CG2	ILE	104	−38.541	10.69	22.577
ATOM	887	CD1	ILE	104	−37.96	8.047	24.281
ATOM	888	HB	ILE	104	−39.508	9.256	21.316
ATOM	889	HG23	ILE	104	−39.083	11.507	22.075
ATOM	890	HG22	ILE	104	−37.534	10.644	22.134
ATOM	891	HG21	ILE	104	−38.445	10.95	23.639
ATOM	892	HG12	ILE	104	−37.465	8.172	22.165
ATOM	893	HG11	ILE	104	−38.864	7.167	22.552
ATOM	894	HD13	ILE	104	−37.589	9.009	24.644
ATOM	895	HD12	ILE	104	−37.154	7.308	24.413
ATOM	896	HD11	ILE	104	−38.797	7.741	24.923
ATOM	897	H	ILE	104	−41.182	7.582	22.006
ATOM	898	HA	ILE	104	−40.425	9.282	24.217
ATOM	899	N	THR	105	−42.473	10.633	22.085
ATOM	900	CA	THR	105	−43.289	11.836	21.913
ATOM	901	C	THR	105	−43.886	12.35	23.203
ATOM	902	O	THR	105	−44.182	13.534	23.26
ATOM	903	CB	THR	105	−44.466	11.536	20.938
ATOM	904	OG1	THR	105	−43.891	11.196	19.667
ATOM	905	CG2	THR	105	−45.428	12.738	20.738
ATOM	906	HB	THR	105	−45.038	10.68	21.34
ATOM	907	HG22	THR	105	−46.145	12.525	19.931
ATOM	908	HG21	THR	105	−44.847	13.632	20.465
ATOM	909	HG23	THR	105	−46.007	12.944	21.65
ATOM	910	HG1	THR	105	−44.533	10.882	19.041
ATOM	911	H	THR	105	−42.68	9.835	21.518
ATOM	912	HA	THR	105	−42.658	12.625	21.474
ATOM	913	N	LEU	106	−44.103	11.528	24.253
ATOM	914	CA	LEU	106	−44.909	11.99	25.386
ATOM	915	C	LEU	106	−44.136	12.891	26.33
ATOM	916	O	LEU	106	−44.145	12.641	27.525
ATOM	917	CB	LEU	106	−45.563	10.781	26.121
ATOM	918	CG	LEU	106	−46.321	9.778	25.193
ATOM	919	CD1	LEU	106	−47.005	8.679	26.054
ATOM	920	CD2	LEU	106	−47.37	10.478	24.286
ATOM	921	HB2	LEU	106	−44.768	10.227	26.647
ATOM	922	HB1	LEU	106	−46.263	11.169	26.879
ATOM	923	HG	LEU	106	−45.607	9.257	24.533
ATOM	924	HD13	LEU	106	−46.261	8.163	26.681
ATOM	925	HD12	LEU	106	−47.491	7.928	25.412
ATOM	926	HD11	LEU	106	−47.769	9.124	26.71
ATOM	927	HD23	LEU	106	−48.065	11.076	24.896
ATOM	928	HD22	LEU	106	−47.951	9.73	23.724
ATOM	929	HD21	LEU	106	−46.882	11.135	23.551
ATOM	930	H	LEU	106	−43.728	10.599	24.274
ATOM	931	HA	LEU	106	−45.734	12.623	25.021
ATOM	932	N	LEU	107	−43.47	13.96	25.831
ATOM	933	CA	LEU	107	−42.716	14.85	26.712
ATOM	934	C	LEU	107	−41.766	14.029	27.558
ATOM	935	O	LEU	107	−41.629	14.28	28.745
ATOM	936	CB	LEU	107	−43.643	15.748	27.582
ATOM	937	CG	LEU	107	−44.645	16.666	26.812
ATOM	938	CD1	LEU	107	−43.938	17.587	25.779
ATOM	939	CD2	LEU	107	−45.821	15.896	26.147
ATOM	940	HB2	LEU	107	−44.21	15.109	28.277
ATOM	941	HB1	LEU	107	−42.994	16.399	28.194
ATOM	942	HG	LEU	107	−45.101	17.322	27.577
ATOM	943	HD13	LEU	107	−43.093	18.114	26.247
ATOM	944	HD12	LEU	107	−44.644	18.34	25.396
ATOM	945	HD11	LEU	107	−43.564	17.004	24.924
ATOM	946	HD23	LEU	107	−46.604	16.606	25.836
ATOM	947	HD22	LEU	107	−45.502	15.349	25.251
ATOM	948	HD21	LEU	107	−46.269	15.181	26.855
ATOM	949	H	LEU	107	−43.476	14.168	24.851
ATOM	950	HA	LEU	107	−42.056	15.503	26.117
ATOM	951	N	ASN	108	−41.094	13.021	26.958
ATOM	952	CA	ASN	108	−40.25	12.131	27.753
ATOM	953	C	ASN	108	−38.991	12.866	28.163
ATOM	954	O	ASN	108	−37.937	12.615	27.602
ATOM	955	CB	ASN	108	−39.947	10.812	26.99
ATOM	956	CG	ASN	108	−41.23	10.117	26.598
ATOM	957	OD1	ASN	108	−42.183	10.794	26.253
ATOM	958	ND2	ASN	108	−41.309	8.771	26.614
ATOM	959	H2	ASN	108	−41.191	12.841	25.975
ATOM	960	HA	ASN	108	−40.794	11.835	28.667
ATOM	961	HB2	ASN	108	−39.378	11.029	26.074
ATOM	962	HB1	ASN	108	−39.341	10.153	27.628
ATOM	963	HD21	ASN	108	−40.543	8.191	26.888
ATOM	964	HD22	ASN	108	−42.169	8.349	26.32
ATOM	965	N	SER	109	−39.072	13.784	29.153
ATOM	966	CA	SER	109	−37.874	14.492	29.608
ATOM	967	C	SER	109	−36.989	13.528	30.371
ATOM	968	O	SER	109	−36.956	13.567	31.591
ATOM	969	CB	SER	109	−38.251	15.723	30.475
ATOM	970	OG	SER	109	−37.054	16.445	30.818
ATOM	971	H	SER	109	−39.951	13.974	29.599
ATOM	972	HA	SER	109	−37.314	14.88	28.74
ATOM	973	HB2	SER	109	−38.927	16.375	29.895
ATOM	974	HB1	SER	109	−38.778	15.39	31.385
ATOM	975	HG	SER	109	−37.223	17.211	31.358
ATOM	976	N	THR	110	−36.259	12.64	29.661
ATOM	977	CA	THR	110	−35.367	11.694	30.333
ATOM	978	C	THR	110	−34.048	12.371	30.639
ATOM	979	O	THR	110	−33.576	12.278	31.761
ATOM	980	CB	THR	110	−35.109	10.476	29.406
ATOM	981	OG1	THR	110	−34.517	10.981	28.199
ATOM	982	CG2	THR	110	−36.416	9.699	29.097
ATOM	983	H	THR	110	−36.294	12.636	28.659
ATOM	984	HA	THR	110	−35.82	11.33	31.27
ATOM	985	HB	THR	110	−34.413	9.785	29.903
ATOM	986	HG22	THR	110	−36.209	8.844	28.436
ATOM	987	HG21	THR	110	−37.136	10.352	28.591
ATOM	988	HG23	THR	110	−36.871	9.322	30.026
ATOM	989	HG1	THR	110	−34.276	10.291	27.593
ATOM	990	N	ASP	111	−33.437	13.054	29.643
ATOM	991	CA	ASP	111	−32.171	13.758	29.862
ATOM	992	C	ASP	111	−32.188	15.035	29.045
ATOM	993	O	ASP	111	−33.214	15.32	28.448
ATOM	994	CB	ASP	111	−31.042	12.786	29.42
ATOM	995	CG	ASP	111	−29.659	13.358	29.572
ATOM	996	OD1	ASP	111	−29.488	14.272	30.424
ATOM	997	OD2	ASP	111	−28.736	12.932	28.832
ATOM	998	H	ASP	111	−33.813	13.069	28.712
ATOM	999	HA	ASP	111	−32.038	14.045	30.918
ATOM	1000	HB2	ASP	111	−31.096	11.881	30.038
ATOM	1001	HB1	ASP	111	−31.194	12.492	28.37
ATOM	1002	N	THR	112	−31.091	15.825	28.978
ATOM	1003	CA	THR	112	−31.031	16.909	27.997
ATOM	1004	C	THR	112	−31.545	16.431	26.654
ATOM	1005	O	THR	112	−32.247	17.19	26.003
ATOM	1006	CB	THR	112	−29.606	17.516	27.854
ATOM	1007	OG1	THR	112	−29.694	18.682	27.014
ATOM	1008	CG2	THR	112	−28.576	16.514	27.263
ATOM	1009	H	THR	112	−30.311	15.679	29.59
ATOM	1010	HA	THR	112	−31.7	17.71	28.355
ATOM	1011	HB	THR	112	−29.269	17.825	28.861
ATOM	1012	HG22	THR	112	−27.57	16.961	27.277
ATOM	1013	HG21	THR	112	−28.827	16.275	26.219
ATOM	1014	HG23	THR	112	−28.544	15.583	27.848
ATOM	1015	HG1	THR	112	−28.861	19.132	26.91
ATOM	1016	N	ASP	113	−31.239	15.177	26.234
ATOM	1017	CA	ASP	113	−31.899	14.601	25.061
ATOM	1018	C	ASP	113	−33.052	13.766	25.574
ATOM	1019	O	ASP	113	−32.995	13.302	26.702
ATOM	1020	CB	ASP	113	−30.934	13.744	24.2
ATOM	1021	CG	ASP	113	−31.494	13.432	22.834
ATOM	1022	OD1	ASP	113	−32.735	13.554	22.636
ATOM	1023	OD2	ASP	113	−30.687	13.068	21.936
ATOM	1024	H	ASP	113	−30.658	14.567	26.777
ATOM	1025	HA	ASP	113	−32.287	15.4	24.407
ATOM	1026	HB2	ASP	113	−30.003	14.314	24.059
ATOM	1027	HB1	ASP	113	−30.69	12.806	24.722
ATOM	1028	N	ALA	114	−34.124	13.55	24.783
ATOM	1029	CA	ALA	114	−35.301	12.874	25.324
ATOM	1030	C	ALA	114	−35.183	11.366	25.309
ATOM	1031	O	ALA	114	−36.186	10.731	25.59
ATOM	1032	CB	ALA	114	−36.563	13.317	24.536
ATOM	1033	H	ALA	114	−34.104	13.829	23.817
ATOM	1034	HA	ALA	114	−35.456	13.18	26.371
ATOM	1035	HB3	ALA	114	−36.497	12.967	23.494
ATOM	1036	HB2	ALA	114	−36.636	14.415	24.537
ATOM	1037	HB1	ALA	114	−37.48	12.908	24.988
ATOM	1038	N	GLN	115	−34.021	10.747	24.991
ATOM	1039	CA	GLN	115	−34.004	9.3	24.768
ATOM	1040	C	GLN	115	−32.69	8.593	25.057
ATOM	1041	O	GLN	115	−32.482	7.527	24.497
ATOM	1042	CB	GLN	115	−34.457	9.105	23.291
ATOM	1043	CG	GLN	115	−33.773	10.07	22.272
ATOM	1044	CD	GLN	115	−32.287	10.296	22.442
ATOM	1045	OE1	GLN	115	−31.856	10.582	23.548
ATOM	1046	NE2	GLN	115	−31.461	10.222	21.379
ATOM	1047	H	GLN	115	−33.188	11.26	24.773
ATOM	1048	HA	GLN	115	−34.719	8.785	25.43
ATOM	1049	HB2	GLN	115	−35.535	9.317	23.238
ATOM	1050	HB1	GLN	115	−34.329	8.055	22.989
ATOM	1051	HG2	GLN	115	−34.007	9.716	21.255
ATOM	1052	HG1	GLN	115	−34.218	11.073	22.373
ATOM	1053	HE21	GLN	115	−30.494	10.442	21.502
ATOM	1054	HE22	GLN	115	−31.79	9.98	20.464
ATOM	1055	N	SER	116	−31.789	9.125	25.918
ATOM	1056	CA	SER	116	−30.476	8.497	26.086
ATOM	1057	C	SER	116	−29.873	8.784	27.447
ATOM	1058	O	SER	116	−30.367	9.661	28.138
ATOM	1059	CB	SER	116	−29.517	9	24.977
ATOM	1060	OG	SER	116	−29.894	8.429	23.712
ATOM	1061	H	SER	116	−31.954	9.984	26.405
ATOM	1062	HA	SER	116	−30.559	7.406	25.983
ATOM	1063	HB2	SER	116	−29.564	10.101	24.939
ATOM	1064	HB1	SER	116	−28.481	8.695	25.199
ATOM	1065	HG	SER	116	−29.34	8.725	22.997
ATOM	1066	N	PHE	117	−28.804	8.045	27.836
ATOM	1067	CA	PHE	117	−28.105	8.303	29.097
ATOM	1068	C	PHE	117	−28.971	7.991	30.302
ATOM	1069	O	PHE	117	−28.699	7.011	30.979
ATOM	1070	CB	PHE	117	−27.476	9.723	29.11
ATOM	1071	CG	PHE	117	−26.754	9.951	27.773
ATOM	1072	CD1	PHE	117	−27.324	10.755	26.778
ATOM	1073	CD2	PHE	117	−25.517	9.342	27.535
ATOM	1074	CE1	PHE	117	−26.678	10.926	25.55
ATOM	1075	CE2	PHE	117	−24.874	9.503	26.304
ATOM	1076	CZ	PHE	117	−25.457	10.291	25.308
ATOM	1077	H	PHE	117	−28.472	7.287	27.267
ATOM	1078	HA	PHE	117	−27.247	7.608	29.156
ATOM	1079	HB2	PHE	117	−28.241	10.497	29.252
ATOM	1080	HB1	PHE	117	−26.763	9.819	29.944
ATOM	1081	HD1	PHE	117	−28.274	11.249	26.949
ATOM	1082	HD2	PHE	117	−25.05	8.737	28.306
ATOM	1083	HE1	PHE	117	−27.127	11.55	24.784
ATOM	1084	HE2	PHE	117	−23.921	9.016	26.121
ATOM	1085	HZ	PHE	117	−24.962	10.411	24.348
ATOM	1086	N	THR	118	−30.025	8.782	30.601
ATOM	1087	CA	THR	118	−30.92	8.422	31.704
ATOM	1088	C	THR	118	−31.613	7.136	31.308
ATOM	1089	O	THR	118	−31.634	6.203	32.095
ATOM	1090	CB	THR	118	−31.938	9.556	32.003
ATOM	1091	OG1	THR	118	−31.216	10.704	32.484
ATOM	1092	CG2	THR	118	−33.005	9.12	33.042
ATOM	1093	H	THR	118	−30.248	9.57	30.027
ATOM	1094	HA	THR	118	−30.327	8.254	32.618
ATOM	1095	HB	THR	118	−32.435	9.823	31.06
ATOM	1096	HG22	THR	118	−33.7	9.95	33.245
ATOM	1097	HG21	THR	118	−32.515	8.834	33.984
ATOM	1098	HG23	THR	118	−33.593	8.266	32.672
ATOM	1099	HG1	THR	118	−31.778	11.465	32.613
ATOM	1100	N	VAL	119	−32.161	7.073	30.073
ATOM	1101	CA	VAL	119	−32.589	5.796	29.495
ATOM	1102	C	VAL	119	−31.559	5.473	28.44
ATOM	1103	O	VAL	119	−30.738	6.333	28.18
ATOM	1104	CB	VAL	119	−34.025	5.858	28.893
ATOM	1105	CG1	VAL	119	−35.031	6.326	29.979
ATOM	1106	CG2	VAL	119	−34.115	6.759	27.629
ATOM	1107	H	VAL	119	−32.138	7.868	29.466
ATOM	1108	HA	VAL	119	−32.563	4.984	30.239
ATOM	1109	HB	VAL	119	−34.314	4.838	28.581
ATOM	1110	HG23	VAL	119	−33.871	7.803	27.865
ATOM	1111	HG22	VAL	119	−35.134	6.728	27.214
ATOM	1112	HG21	VAL	119	−33.425	6.41	26.847
ATOM	1113	HG13	VAL	119	−34.999	5.649	30.847
ATOM	1114	HG12	VAL	119	−36.057	6.331	29.58
ATOM	1115	HG11	VAL	119	−34.783	7.34	30.323
ATOM	1116	N	ASN	120	−31.541	4.283	27.804
ATOM	1117	CA	ASN	120	−30.526	4.03	26.778
ATOM	1118	C	ASN	120	−31.129	3.176	25.69
ATOM	1119	O	ASN	120	−30.686	2.055	25.496
ATOM	1120	CB	ASN	120	−29.251	3.429	27.42
ATOM	1121	CG	ASN	120	−28.626	4.459	28.334
ATOM	1122	OD1	ASN	120	−27.782	5.212	27.874
ATOM	1123	ND2	ASN	120	−29.023	4.542	29.621
ATOM	1124	H	ASN	120	−32.184	3.553	28.039
ATOM	1125	HA	ASN	120	−30.222	4.954	26.259
ATOM	1126	HB2	ASN	120	−29.508	2.514	27.976
ATOM	1127	HB1	ASN	120	−28.527	3.16	26.634
ATOM	1128	HD21	ASN	120	−29.717	3.932	30.001
ATOM	1129	HD22	ASN	120	−28.625	5.249	30.211
ATOM	1130	N	ILE	121	−32.149	3.72	24.983
ATOM	1131	CA	ILE	121	−32.79	2.991	23.886
ATOM	1132	C	ILE	121	−32.498	3.576	22.52
ATOM	1133	O	ILE	121	−32.731	2.862	21.556
ATOM	1134	CB	ILE	121	−34.33	2.879	24.117
ATOM	1135	CG1	ILE	121	−35.085	4.22	23.851
ATOM	1136	CG2	ILE	121	−34.601	2.329	25.546
ATOM	1137	CD1	ILE	121	−36.63	4.07	23.924
ATOM	1138	H	ILE	121	−32.487	4.634	25.209
ATOM	1139	HA	ILE	121	−32.401	1.959	23.841
ATOM	1140	HB	ILE	121	−34.714	2.141	23.39
ATOM	1141	HG23	ILE	121	−33.984	1.437	25.737
ATOM	1142	HG22	ILE	121	−35.654	2.035	25.668
ATOM	1143	HG21	ILE	121	−34.358	3.088	26.305
ATOM	1144	HG12	ILE	121	−34.846	4.579	22.836
ATOM	1145	HG11	ILE	121	−34.771	4.997	24.565
ATOM	1146	HD13	ILE	121	−36.968	3.23	23.298
ATOM	1147	HD12	ILE	121	−37.118	4.985	23.556
ATOM	1148	HD11	ILE	121	−36.966	3.902	24.958
ATOM	1149	N	ASP	122	−32.014	4.834	22.361
ATOM	1150	CA	ASP	122	−31.797	5.358	21.011
ATOM	1151	C	ASP	122	−30.553	4.711	20.441
ATOM	1152	O	ASP	122	−29.515	5.346	20.342
ATOM	1153	CB	ASP	122	−31.709	6.905	20.983
ATOM	1154	CG	ASP	122	−31.841	7.421	19.575
ATOM	1155	OD1	ASP	122	−32.206	8.62	19.412
ATOM	1156	OD2	ASP	122	−31.601	6.646	18.61
ATOM	1157	HB2	ASP	122	−32.542	7.317	21.568
ATOM	1158	HB1	ASP	122	−30.768	7.26	21.426
ATOM	1159	H8	ASP	122	−31.776	5.426	23.132
ATOM	1160	HA	ASP	122	−32.67	5.099	20.389
ATOM	1161	N	ASN	123	−30.646	3.415	20.068
ATOM	1162	CA	ASN	123	−29.472	2.689	19.592
ATOM	1163	C	ASN	123	−29.912	1.601	18.634
ATOM	1164	O	ASN	123	−29.549	1.657	17.47
ATOM	1165	CB	ASN	123	−28.694	2.111	20.806
ATOM	1166	CG	ASN	123	−28.313	3.192	21.79
ATOM	1167	OD1	ASN	123	−28.912	3.27	22.851
ATOM	1168	ND2	ASN	123	−27.323	4.052	21.475
ATOM	1169	H	ASN	123	−31.513	2.926	20.172
ATOM	1170	HB2	ASN	123	−27.787	1.594	20.456
ATOM	1171	HB1	ASN	123	−29.308	1.377	21.346
ATOM	1172	HD21	ASN	123	−26.834	3.987	20.608
ATOM	1173	HD22	ASN	123	−27.085	4.78	22.119
ATOM	1174	HA	ASN	123	−28.805	3.368	19.031
ATOM	1175	N	VAL	124	−30.71	0.598	19.074
ATOM	1176	CA	VAL	124	−31.166	−0.419	18.129
ATOM	1177	C	VAL	124	−32.048	0.246	17.098
ATOM	1178	O	VAL	124	−31.919	−0.077	15.929
ATOM	1179	CB	VAL	124	−31.897	−1.644	18.766
ATOM	1180	CG1	VAL	124	−30.979	−2.373	19.787
ATOM	1181	CG2	VAL	124	−33.265	−1.292	19.417
ATOM	1182	HB	VAL	124	−32.108	−2.356	17.947
ATOM	1183	HG23	VAL	124	−33.152	−0.546	20.217
ATOM	1184	HG22	VAL	124	−33.715	−2.195	19.857
ATOM	1185	HG21	VAL	124	−33.973	−0.904	18.668
ATOM	1186	HG13	VAL	124	−30.019	−2.642	19.32
ATOM	1187	HG12	VAL	124	−31.46	−3.3	20.138
ATOM	1188	HG11	VAL	124	−30.776	−1.742	20.664
ATOM	1189	HA	VAL	124	−30.277	−0.811	17.605
ATOM	1190	H	VAL	124	−31.036	0.559	20.017
ATOM	1191	N	ILE	125	−32.947	1.178	17.494
ATOM	1192	CA	ILE	125	−33.829	1.792	16.502
ATOM	1193	C	ILE	125	−32.977	2.402	15.415
ATOM	1194	O	ILE	125	−33.132	2.068	14.25
ATOM	1195	CB	ILE	125	−34.867	2.785	17.112
ATOM	1196	CG1	ILE	125	−36.024	3.134	16.122
ATOM	1197	CG2	ILE	125	−34.239	4.066	17.733
ATOM	1198	CD1	ILE	125	−35.597	3.651	14.722
ATOM	1199	HB	ILE	125	−35.339	2.248	17.956
ATOM	1200	HG23	ILE	125	−33.421	3.812	18.42
ATOM	1201	HG22	ILE	125	−34.992	4.608	18.322
ATOM	1202	HG21	ILE	125	−33.858	4.755	16.966
ATOM	1203	HG12	ILE	125	−36.644	3.903	16.597
ATOM	1204	HG11	ILE	125	−36.668	2.255	15.973
ATOM	1205	HD13	ILE	125	−34.74	4.335	14.773
ATOM	1206	HD12	ILE	125	−36.423	4.194	14.249
ATOM	1207	HD11	ILE	125	−35.363	2.808	14.058
ATOM	1208	H	ILE	125	−33.031	1.443	18.454
ATOM	1209	HA	ILE	125	−34.424	0.978	16.067
ATOM	1210	N	ASP	126	−32.035	3.303	15.753
ATOM	1211	CA	ASP	126	−31.298	3.958	14.684
ATOM	1212	C	ASP	126	−30.511	2.916	13.95
ATOM	1213	O	ASP	126	−30.508	2.864	12.731
ATOM	1214	CB	ASP	126	−30.295	4.999	15.222
ATOM	1215	CG	ASP	126	−29.736	5.716	14.023
ATOM	1216	OD1	ASP	126	−30.342	6.755	13.64
ATOM	1217	OD2	ASP	126	−28.714	5.231	13.461
ATOM	1218	HB2	ASP	126	−30.845	5.677	15.888
ATOM	1219	HB1	ASP	126	−29.481	4.535	15.802
ATOM	1220	H	ASP	126	−31.802	3.509	16.703
ATOM	1221	HA	ASP	126	−32.011	4.451	14.002
ATOM	1222	N	SER	127	−29.801	2.048	14.69
ATOM	1223	CA	SER	127	−28.88	1.171	13.998
ATOM	1224	C	SER	127	−29.609	0.084	13.22
ATOM	1225	O	SER	127	−28.979	−0.475	12.334
ATOM	1226	CB	SER	127	−27.688	0.874	14.946
ATOM	1227	OG	SER	127	−27.286	2.083	15.646
ATOM	1228	HB2	SER	127	−28.016	0.147	15.705
ATOM	1229	HB1	SER	127	−26.843	0.434	14.393
ATOM	1230	HG	SER	127	−27.078	2.868	15.131
ATOM	1231	H	SER	127	−29.849	2.014	15.694
ATOM	1232	HA	SER	127	−28.414	1.775	13.208
ATOM	1233	N	VAL	128	−30.921	−0.212	13.441
ATOM	1234	CA	VAL	128	−31.667	−0.99	12.441
ATOM	1235	C	VAL	128	−31.94	−0.112	11.235
ATOM	1236	O	VAL	128	−31.943	−0.627	10.128
ATOM	1237	CB	VAL	128	−32.996	−1.707	12.84
ATOM	1238	CG1	VAL	128	−32.764	−2.763	13.957
ATOM	1239	CG2	VAL	128	−34.15	−0.744	13.23
ATOM	1240	HB	VAL	128	−33.352	−2.258	11.948
ATOM	1241	HG23	VAL	128	−33.908	−0.267	14.182
ATOM	1242	HG22	VAL	128	−35.093	−1.299	13.359
ATOM	1243	HG21	VAL	128	−34.316	0.033	12.469
ATOM	1244	HG13	VAL	128	−32.024	−3.511	13.635
ATOM	1245	HG12	VAL	128	−33.704	−3.287	14.192
ATOM	1246	HG11	VAL	128	−32.396	−2.285	14.875
ATOM	1247	H	VAL	128	−31.431	0.19	14.204
ATOM	1248	HA	VAL	128	−31.007	−1.81	12.116
ATOM	1249	N	ILE	129	−32.165	1.214	11.372
ATOM	1250	CA	ILE	129	−32.257	2.043	10.168
ATOM	1251	C	ILE	129	−30.974	1.853	9.39
ATOM	1252	O	ILE	129	−31.03	1.665	8.184
ATOM	1253	CB	ILE	129	−32.607	3.536	10.461
ATOM	1254	CG1	ILE	129	−34.092	3.641	10.914
ATOM	1255	CG2	ILE	129	−32.332	4.434	9.225
ATOM	1256	CD1	ILE	129	−34.483	5.018	11.505
ATOM	1257	HB	ILE	129	−31.967	3.921	11.266
ATOM	1258	HG23	ILE	129	−31.277	4.363	8.927
ATOM	1259	HG22	ILE	129	−32.529	5.489	9.459
ATOM	1260	HG21	ILE	129	−32.967	4.128	8.38
ATOM	1261	HG12	ILE	129	−34.303	2.871	11.674
ATOM	1262	HG11	ILE	129	−34.73	3.452	10.04
ATOM	1263	HD13	ILE	129	−33.82	5.281	12.343
ATOM	1264	HD12	ILE	129	−35.519	4.978	11.876
ATOM	1265	HD11	ILE	129	−34.423	5.807	10.743
ATOM	1266	H	ILE	129	−32.196	1.652	12.273
ATOM	1267	HA	ILE	129	−33.054	1.639	9.528
ATOM	1268	N	CYS	130	−29.795	1.864	10.046
ATOM	1269	CA	CYS	130	−28.576	1.565	9.297
ATOM	1270	C	CYS	130	−28.633	0.158	8.741
ATOM	1271	O	CYS	130	−28.178	−0.035	7.627
ATOM	1272	CB	CYS	130	−27.272	1.78	10.097
ATOM	1273	SG	CYS	130	−27.09	3.566	10.455
ATOM	1274	HG	CYS	130	−27.902	3.7	11.038
ATOM	1275	HB2	CYS	130	−27.293	1.159	11.003
ATOM	1276	HB1	CYS	130	−26.405	1.48	9.488
ATOM	1277	H	CYS	130	−29.755	2.033	11.034
ATOM	1278	HA	CYS	130	−28.528	2.268	8.453
ATOM	1279	LPG2	CYS	130	−27.118	3.942	9.89
ATOM	1280	LPG1	CYS	130	−26.514	3.7	10.788
ATOM	1281	N	SER	131	−29.19	−0.856	9.441
ATOM	1282	CA	SER	131	−29.383	−2.149	8.777
ATOM	1283	C	SER	131	−30.135	−1.931	7.482
ATOM	1284	O	SER	131	−29.727	−2.467	6.464
ATOM	1285	CB	SER	131	−30.15	−3.205	9.617
ATOM	1286	OG	SER	131	−30.301	−4.42	8.861
ATOM	1287	HB2	SER	131	−29.594	−3.396	10.55
ATOM	1288	HB1	SER	131	−31.157	−2.846	9.867
ATOM	1289	HG	SER	131	−30.758	−5.107	9.337
ATOM	1290	H	SER	131	−29.497	−0.727	10.385
ATOM	1291	HA	SER	131	−28.389	−2.564	8.543
ATOM	1292	N	SER	132	−31.229	−1.136	7.475
ATOM	1293	CA	SER	132	−31.916	−0.885	6.207
ATOM	1294	C	SER	132	−30.966	−0.215	5.239
ATOM	1295	O	SER	132	−30.976	−0.567	4.071
ATOM	1296	CB	SER	132	−33.216	−0.051	6.345
ATOM	1297	OG	SER	132	−33.964	−0.18	5.121
ATOM	1298	HB2	SER	132	−33.808	−0.451	7.184
ATOM	1299	HB1	SER	132	−32.981	1.005	6.554
ATOM	1300	HG	SER	132	−34.821	0.241	5.133
ATOM	1301	H	SER	132	−31.558	−0.692	8.312
ATOM	1302	HA	SER	132	−32.203	−1.862	5.788
ATOM	1303	N	LEU	133	−30.122	0.738	5.692
ATOM	1304	CA	LEU	133	−29.123	1.323	4.791
ATOM	1305	C	LEU	133	−28.306	0.205	4.188
ATOM	1306	O	LEU	133	−28.234	0.106	2.974
ATOM	1307	CB	LEU	133	−28.172	2.306	5.534
ATOM	1308	CG	LEU	133	−27.33	3.27	4.649
ATOM	1309	CD1	LEU	133	−26.53	4.219	5.581
ATOM	1310	CD2	LEU	133	−26.34	2.529	3.711
ATOM	1311	HB2	LEU	133	−28.806	2.924	6.179
ATOM	1312	HB1	LEU	133	−27.472	1.767	6.185
ATOM	1313	HG	LEU	133	−28.014	3.883	4.038
ATOM	1314	HD13	LEU	133	−27.199	4.693	6.313
ATOM	1315	HD12	LEU	133	−26.046	5.013	4.997
ATOM	1316	HD11	LEU	133	−25.756	3.657	6.127
ATOM	1317	HD23	LEU	133	−25.823	1.717	4.242
ATOM	1318	HD22	LEU	133	−25.572	3.21	3.316
ATOM	1319	HD21	LEU	133	−26.886	2.112	2.859
ATOM	1320	H	LEU	133	−30.162	1.031	6.65
ATOM	1321	HA	LEU	133	−29.656	1.877	4
ATOM	1322	N	LEU	134	−27.679	−0.654	5.023
ATOM	1323	CA	LEU	134	−26.814	−1.694	4.472
ATOM	1324	C	LEU	134	−27.617	−2.545	3.525
ATOM	1325	O	LEU	134	−27.159	−2.78	2.419
ATOM	1326	CB	LEU	134	−26.118	−2.59	5.535
ATOM	1327	CG	LEU	134	−24.763	−2.031	6.067
ATOM	1328	CD1	LEU	134	−23.654	−2.008	4.978
ATOM	1329	CD2	LEU	134	−24.921	−0.638	6.731
ATOM	1330	HB2	LEU	134	−26.814	−2.735	6.374
ATOM	1331	HB1	LEU	134	−25.914	−3.584	5.101
ATOM	1332	HG	LEU	134	−24.414	−2.736	6.841
ATOM	1333	HD13	LEU	134	−23.587	−2.991	4.497
ATOM	1334	HD12	LEU	134	−22.681	−1.806	5.435
ATOM	1335	HD11	LEU	134	−23.811	−1.238	4.21
ATOM	1336	HD23	LEU	134	−25.276	0.104	6.004
ATOM	1337	HD22	LEU	134	−23.954	−0.29	7.123
ATOM	1338	HD21	LEU	134	−25.637	−0.692	7.564
ATOM	1339	H	LEU	134	−27.811	−0.599	6.014
ATOM	1340	HA	LEU	134	−26.046	−1.202	3.87
ATOM	1341	N	ALA	135	−28.817	−3.01	3.925
ATOM	1342	CA	ALA	135	−29.605	−3.811	2.996
ATOM	1343	C	ALA	135	−29.8	−3.022	1.717
ATOM	1344	O	ALA	135	−29.597	−3.583	0.654
ATOM	1345	CB	ALA	135	−30.959	−4.241	3.616
ATOM	1346	HB3	ALA	135	−31.573	−3.358	3.84
ATOM	1347	HB2	ALA	135	−30.789	−4.797	4.551
ATOM	1348	HB1	ALA	135	−31.506	−4.894	2.919
ATOM	1349	H	ALA	135	−29.183	−2.797	4.833
ATOM	1350	HA	ALA	135	−29.032	−4.726	2.77
ATOM	1351	N	SER	136	−30.173	−1.725	1.783
ATOM	1352	CA	SER	136	−30.371	−0.932	0.567
ATOM	1353	C	SER	136	−29.103	−0.792	−0.245
ATOM	1354	O	SER	136	−29.075	−1.238	−1.382
ATOM	1355	CB	SER	136	−30.978	0.46	0.885
ATOM	1356	OG	SER	136	−32.249	0.255	1.527
ATOM	1357	HB2	SER	136	−30.31	1.029	1.551
ATOM	1358	HB1	SER	136	−31.114	1.031	−0.05
ATOM	1359	HG	SER	136	−32.693	1.064	1.76
ATOM	1360	H	SER	136	−30.317	−1.282	2.669
ATOM	1361	HA	SER	136	−31.115	−1.416	−0.08
ATOM	1362	N	ILE	137	−28.033	−0.163	0.286
ATOM	1363	CA	ILE	137	−26.861	0.078	−0.556
ATOM	1364	C	ILE	137	−26.207	−1.233	−0.937
ATOM	1365	O	ILE	137	−25.762	−1.365	−2.068
ATOM	1366	CB	ILE	137	−25.861	1.106	0.059
ATOM	1367	CG1	ILE	137	−24.88	1.695	−0.998
ATOM	1368	CG2	ILE	137	−25.049	0.468	1.219
ATOM	1369	CD1	ILE	137	−25.529	2.729	−1.961
ATOM	1370	HB	ILE	137	−26.441	1.95	0.463
ATOM	1371	HG23	ILE	137	−25.729	0.046	1.965
ATOM	1372	HG22	ILE	137	−24.415	1.216	1.721
ATOM	1373	HG21	ILE	137	−24.405	−0.337	0.844
ATOM	1374	HG12	ILE	137	−24.438	0.865	−1.564
ATOM	1375	HG11	ILE	137	−24.06	2.214	−0.475
ATOM	1376	HD13	ILE	137	−26.392	2.34	−2.516
ATOM	1377	HD12	ILE	137	−24.792	3.074	−2.699
ATOM	1378	HD11	ILE	137	−25.863	3.598	−1.384
ATOM	1379	H	ILE	137	−28.038	0.147	1.238
ATOM	1380	HA	ILE	137	−27.249	0.516	−1.482
ATOM	1381	N	CYS	138	−26.136	−2.232	−0.028
ATOM	1382	CA	CYS	138	−25.528	−3.504	−0.41
ATOM	1383	C	CYS	138	−26.464	−4.254	−1.328
ATOM	1384	O	CYS	138	−25.971	−4.945	−2.204
ATOM	1385	CB	CYS	138	−25.111	−4.398	0.783
ATOM	1386	SG	CYS	138	−23.851	−3.533	1.773
ATOM	1387	HG	CYS	138	−24.406	−2.745	2.065
ATOM	1388	HB2	CYS	138	−25.976	−4.672	1.401
ATOM	1389	HB1	CYS	138	−24.643	−5.321	0.408
ATOM	1390	H	CYS	138	−26.539	−2.145	0.885
ATOM	1391	HA	CYS	138	−24.597	−3.287	−0.959
ATOM	1392	LPG2	CYS	138	−23.317	−3.345	1.399
ATOM	1393	LPG1	CYS	138	−23.639	−3.906	2.3
ATOM	1394	N	SER	139	−27.806	−4.137	−1.191
ATOM	1395	CA	SER	139	−28.67	−4.694	−2.229
ATOM	1396	C	SER	139	−28.261	−4.046	−3.528
ATOM	1397	O	SER	139	−28.029	−4.754	−4.491
ATOM	1398	CB	SER	139	−30.199	−4.468	−2.081
ATOM	1399	OG	SER	139	−30.757	−5.455	−1.195
ATOM	1400	H	SER	139	−28.226	−3.622	−0.442
ATOM	1401	HB2	SER	139	−30.671	−4.592	−3.069
ATOM	1402	HB1	SER	139	−30.408	−3.443	−1.739
ATOM	1403	HG	SER	139	−31.702	−5.397	−1.107
ATOM	1404	HA	SER	139	−28.503	−5.779	−2.277
ATOM	1405	N	LEU	140	−28.166	−2.702	−3.585
ATOM	1406	CA	LEU	140	−27.821	−2.057	−4.851
ATOM	1407	C	LEU	140	−26.486	−2.568	−5.347
ATOM	1408	O	LEU	140	−26.346	−2.76	−6.545
ATOM	1409	CB	LEU	140	−27.92	−0.51	−4.75
ATOM	1410	CG	LEU	140	−29.391	−0.031	−4.532
ATOM	1411	CD1	LEU	140	−29.42	1.398	−3.923
ATOM	1412	CD2	LEU	140	−30.216	−0.049	−5.85
ATOM	1413	HA	LEU	140	−28.544	−2.386	−5.605
ATOM	1414	H	LEU	140	−28.318	−2.144	−2.764
ATOM	1415	HB2	LEU	140	−27.512	−0.04	−5.659
ATOM	1416	HB1	LEU	140	−27.297	−0.204	−3.899
ATOM	1417	HG	LEU	140	−29.901	−0.699	−3.819
ATOM	1418	HD13	LEU	140	−29.017	1.399	−2.9
ATOM	1419	HD12	LEU	140	−30.448	1.792	−3.884
ATOM	1420	HD11	LEU	140	−28.806	2.07	−4.536
ATOM	1421	HD23	LEU	140	−29.878	0.749	−6.526
ATOM	1422	HD22	LEU	140	−31.275	0.113	−5.61
ATOM	1423	HD21	LEU	140	−30.155	−1.003	−6.386
ATOM	1424	N	LEU	141	−25.5	−2.842	−4.464
ATOM	1425	CA	LEU	141	−24.298	−3.537	−4.929
ATOM	1426	C	LEU	141	−24.697	−4.878	−5.501
ATOM	1427	O	LEU	141	−24.27	−5.209	−6.597
ATOM	1428	CB	LEU	141	−23.234	−3.68	−3.803
ATOM	1429	CG	LEU	141	−21.893	−4.343	−4.25
ATOM	1430	CD1	LEU	141	−20.734	−3.859	−3.332
ATOM	1431	CD2	LEU	141	−21.943	−5.899	−4.2
ATOM	1432	HB2	LEU	141	−23.035	−2.659	−3.442
ATOM	1433	HB1	LEU	141	−23.646	−4.256	−2.964
ATOM	1434	HG	LEU	141	−21.661	−4.031	−5.283
ATOM	1435	HD13	LEU	141	−20.589	−2.771	−3.424
ATOM	1436	HD12	LEU	141	−19.791	−4.353	−3.61
ATOM	1437	HD11	LEU	141	−20.955	−4.1	−2.281
ATOM	1438	HD23	LEU	141	−22.141	−6.243	−3.174
ATOM	1439	HD22	LEU	141	−20.979	−6.321	−4.525
ATOM	1440	HD21	LEU	141	−22.716	−6.317	−4.855
ATOM	1441	H	LEU	141	−25.608	−2.631	−3.489
ATOM	1442	HA	LEU	141	−23.845	−2.945	−5.738
ATOM	1443	N	SER	142	−25.516	−5.685	−4.791
ATOM	1444	CA	SER	142	−25.886	−6.982	−5.346
ATOM	1445	C	SER	142	−26.602	−6.819	−6.669
ATOM	1446	O	SER	142	−26.377	−7.624	−7.56
ATOM	1447	CB	SER	142	−26.725	−7.877	−4.396
ATOM	1448	OG	SER	142	−28.007	−7.332	−4.056
ATOM	1449	HB2	SER	142	−26.864	−8.86	−4.874
ATOM	1450	HB1	SER	142	−26.172	−8.022	−3.455
ATOM	1451	HG	SER	142	−28.549	−7.134	−4.812
ATOM	1452	H	SER	142	−25.887	−5.414	−3.901
ATOM	1453	HA	SER	142	−24.946	−7.528	−5.508
ATOM	1454	N	ILE	143	−27.462	−5.786	−6.831
ATOM	1455	CA	ILE	143	−28.117	−5.588	−8.12
ATOM	1456	C	ILE	143	−27.023	−5.236	−9.104
ATOM	1457	O	ILE	143	−27.05	−5.717	−10.223
ATOM	1458	CB	ILE	143	−29.262	−4.524	−8.171
ATOM	1459	CG1	ILE	143	−30.253	−4.696	−6.977
ATOM	1460	CG2	ILE	143	−30.01	−4.641	−9.535
ATOM	1461	CD1	ILE	143	−31.63	−3.997	−7.149
ATOM	1462	HB	ILE	143	−28.808	−3.522	−8.102
ATOM	1463	HG23	ILE	143	−29.316	−4.663	−10.386
ATOM	1464	HG22	ILE	143	−30.684	−3.786	−9.691
ATOM	1465	HG21	ILE	143	−30.6	−5.569	−9.568
ATOM	1466	HG12	ILE	143	−29.821	−4.283	−6.06
ATOM	1467	HG11	ILE	143	−30.401	−5.765	−6.796
ATOM	1468	HD13	ILE	143	−31.494	−2.932	−7.395
ATOM	1469	HD12	ILE	143	−32.207	−4.066	−6.213
ATOM	1470	HD11	ILE	143	−32.226	−4.473	−7.941
ATOM	1471	H	ILE	143	−27.606	−5.117	−6.104
ATOM	1472	HA	ILE	143	−28.581	−6.547	−8.39
ATOM	1473	N	ALA	144	−26.037	−4.398	−8.717
ATOM	1474	CA	ALA	144	−24.976	−4.031	−9.653
ATOM	1475	C	ALA	144	−24.21	−5.244	−10.142
ATOM	1476	O	ALA	144	−23.999	−5.347	−11.341
ATOM	1477	CB	ALA	144	−24.013	−2.999	−9.01
ATOM	1478	H	ALA	144	−26.024	−4.005	−7.795
ATOM	1479	HB3	ALA	144	−23.425	−3.466	−8.208
ATOM	1480	HB2	ALA	144	−24.578	−2.152	−8.592
ATOM	1481	HB1	ALA	144	−23.318	−2.601	−9.759
ATOM	1482	HA	ALA	144	−25.448	−3.55	−10.527
ATOM	1483	N	VAL	145	−23.781	−6.186	−9.267
ATOM	1484	CA	VAL	145	−23.054	−7.358	−9.773
ATOM	1485	C	VAL	145	−24.005	−8.249	−10.541
ATOM	1486	O	VAL	145	−23.624	−8.761	−11.582
ATOM	1487	CB	VAL	145	−22.222	−8.168	−8.732
ATOM	1488	CG1	VAL	145	−21.291	−7.235	−7.908
ATOM	1489	CG2	VAL	145	−23.11	−9.037	−7.805
ATOM	1490	HB	VAL	145	−21.577	−8.872	−9.289
ATOM	1491	HG23	VAL	145	−23.831	−8.397	−7.291
ATOM	1492	HG22	VAL	145	−22.497	−9.553	−7.049
ATOM	1493	HG21	VAL	145	−23.661	−9.8	−8.375
ATOM	1494	HG13	VAL	145	−20.638	−6.656	−8.579
ATOM	1495	HG12	VAL	145	−20.65	−7.828	−7.237
ATOM	1496	HG11	VAL	145	−21.869	−6.531	−7.294
ATOM	1497	H	VAL	145	−23.998	−6.105	−8.291
ATOM	1498	HA	VAL	145	−22.314	−6.992	−10.502
ATOM	1499	N	ASP	146	−25.261	−8.434	−10.073
ATOM	1500	CA	ASP	146	−26.242	−9.129	−10.909
ATOM	1501	C	ASP	146	−26.257	−8.447	−12.257
ATOM	1502	O	ASP	146	−26.249	−9.13	−13.266
ATOM	1503	CB	ASP	146	−27.656	−9.085	−10.271
ATOM	1504	CG	ASP	146	−28.778	−9.541	−11.167
ATOM	1505	OD1	ASP	146	−29.797	−8.801	−11.267
ATOM	1506	OD2	ASP	146	−28.664	−10.637	−11.773
ATOM	1507	HB2	ASP	146	−27.662	−9.69	−9.352
ATOM	1508	HB1	ASP	146	−27.872	−8.047	−10.001
ATOM	1509	H	ASP	146	−25.554	−8.044	−9.196
ATOM	1510	HA	ASP	146	−25.943	−10.182	−11.041
ATOM	1511	N	ARG	147	−26.256	−7.097	−12.315
ATOM	1512	CA	ARG	147	−26.312	−6.417	−13.609
ATOM	1513	C	ARG	147	−25.029	−6.601	−14.387
ATOM	1514	O	ARG	147	−25.093	−6.658	−15.605
ATOM	1515	CB	ARG	147	−26.667	−4.906	−13.454
ATOM	1516	CG	ARG	147	−27.568	−4.333	−14.59
ATOM	1517	CD	ARG	147	−28.822	−5.183	−14.99
ATOM	1518	NE	ARG	147	−29.462	−5.962	−13.919
ATOM	1519	CZ	ARG	147	−30.428	−6.83	−14.127
ATOM	1520	NH1	ARG	147	−30.987	−7.007	−15.299
ATOM	1521	NH2	ARG	147	−30.855	−7.561	−13.125
ATOM	1522	H	ARG	147	−26.207	−6.558	−11.475
ATOM	1523	HB2	ARG	147	−25.734	−4.322	−13.382
ATOM	1524	HB1	ARG	147	−27.199	−4.728	−12.509
ATOM	1525	HG2	ARG	147	−26.945	−4.173	−15.488
ATOM	1526	HG1	ARG	147	−27.905	−3.338	−14.254
ATOM	1527	HD2	ARG	147	−28.486	−5.889	−15.769
ATOM	1528	HD1	ARG	147	−29.566	−4.509	−15.444
ATOM	1529	HE	ARG	147	−29.111	−5.848	−12.959
ATOM	1530	HH11	ARG	147	−30.704	−6.462	−16.125
ATOM	1531	HH12	ARG	147	−31.733	−7.703	−15.428
ATOM	1532	HH21	ARG	147	−30.419	−7.504	−12.188
ATOM	1533	HH22	ARG	147	−31.601	−8.259	−13.246
ATOM	1534	HA	ARG	147	−27.096	−6.932	−14.179
ATOM	1535	N	TYR	148	−23.855	−6.704	−13.723
ATOM	1536	CA	TYR	148	−22.627	−7.015	−14.457
ATOM	1537	C	TYR	148	−22.824	−8.283	−15.255
ATOM	1538	O	TYR	148	−22.476	−8.309	−16.425
ATOM	1539	CB	TYR	148	−21.411	−7.208	−13.509
ATOM	1540	CG	TYR	148	−20.105	−7.416	−14.291
ATOM	1541	CD1	TYR	148	−19.188	−6.37	−14.441
ATOM	1542	CD2	TYR	148	−19.811	−8.662	−14.857
ATOM	1543	CE1	TYR	148	−18.015	−6.548	−15.18
ATOM	1544	CE2	TYR	148	−18.648	−8.838	−15.612
ATOM	1545	CZ	TYR	148	−17.747	−7.784	−15.783
ATOM	1546	OH	TYR	148	−16.595	−7.986	−16.55
ATOM	1547	H	TYR	148	−23.818	−6.593	−12.728
ATOM	1548	HB1	TYR	148	−21.562	−8.077	−12.852
ATOM	1549	HB2	TYR	148	−21.319	−6.322	−12.868
ATOM	1550	HD1	TYR	148	−19.378	−5.408	−13.98
ATOM	1551	HD2	TYR	148	−20.483	−9.502	−14.714
ATOM	1552	HE1	TYR	148	−17.319	−5.721	−15.28
ATOM	1553	HE2	TYR	148	−18.438	−9.799	−16.069
ATOM	1554	HH	TYR	148	−16.054	−7.212	−16.656
ATOM	1555	HA	TYR	148	−22.403	−6.185	−15.145
ATOM	1556	N	PHE	149	−23.371	−9.352	−14.632
ATOM	1557	CA	PHE	149	−23.567	−10.604	−15.364
ATOM	1558	C	PHE	149	−24.829	−10.531	−16.196
ATOM	1559	O	PHE	149	−24.772	−10.699	−17.403
ATOM	1560	CB	PHE	149	−23.626	−11.809	−14.386
ATOM	1561	CG	PHE	149	−23.95	−13.092	−15.163
ATOM	1562	CD1	PHE	149	−22.924	−13.828	−15.766
ATOM	1563	CD2	PHE	149	−25.273	−13.536	−15.277
ATOM	1564	CE1	PHE	149	−23.215	−14.998	−16.472
ATOM	1565	CE2	PHE	149	−25.567	−14.704	−15.986
ATOM	1566	CZ	PHE	149	−24.537	−15.438	−16.582
ATOM	1567	HB2	PHE	149	−22.656	−11.911	−13.874
ATOM	1568	HB1	PHE	149	−24.387	−11.651	−13.607
ATOM	1569	HD1	PHE	149	−21.895	−13.491	−15.691
ATOM	1570	HD2	PHE	149	−26.081	−12.976	−14.817
ATOM	1571	HE1	PHE	149	−22.415	−15.567	−16.936
ATOM	1572	HE2	PHE	149	−26.595	−15.042	−16.073
ATOM	1573	HZ	PHE	149	−24.765	−16.347	−17.131
ATOM	1574	H	PHE	149	−23.679	−9.287	−13.678
ATOM	1575	HA	PHE	149	−22.715	−10.782	−16.043
ATOM	1576	N	THR	150	−25.993	−10.288	−15.558
ATOM	1577	CA	THR	150	−27.253	−10.215	−16.292
ATOM	1578	C	THR	150	−27.223	−9.01	−17.195
ATOM	1579	O	THR	150	−27.582	−9.091	−18.359
ATOM	1580	CB	THR	150	−28.427	−10.103	−15.279
ATOM	1581	OG1	THR	150	−28.26	−11.179	−14.339
ATOM	1582	CG2	THR	150	−29.81	−10.199	−15.971
ATOM	1583	HB	THR	150	−28.351	−9.133	−14.755
ATOM	1584	HG22	THR	150	−30.61	−10.122	−15.218
ATOM	1585	HG21	THR	150	−29.907	−11.166	−16.486
ATOM	1586	HG23	THR	150	−29.936	−9.39	−16.706
ATOM	1587	HG1	THR	150	−28.817	−11.101	−13.566
ATOM	1588	H	THR	150	−26.015	−10.154	−14.568
ATOM	1589	HA	THR	150	−27.377	−11.137	−16.883
ATOM	1590	H6	THR	150	−26.882	−8.052	−16.809
TER			THR	150
ATOM	1591	CA	VAL	163	−32.898	−19.944	−5.256
ATOM	1592	C	VAL	163	−31.593	−19.843	−4.496
ATOM	1593	O	VAL	163	−31.517	−19.075	−3.551
ATOM	1594	CB	VAL	163	−33.784	−21.125	−4.763
ATOM	1595	CG1	VAL	163	−35.136	−21.131	−5.53
ATOM	1596	CG2	VAL	163	−33.078	−22.5	−4.918
ATOM	1597	HB	VAL	163	−34	−20.97	−3.69
ATOM	1598	HG23	VAL	163	−32.781	−22.664	−5.965
ATOM	1599	HG22	VAL	163	−33.757	−23.313	−4.617
ATOM	1600	HG21	VAL	163	−32.185	−22.559	−4.278
ATOM	1601	HG13	VAL	163	−35.664	−20.173	−5.396
ATOM	1602	HG12	VAL	163	−35.789	−21.935	−5.158
ATOM	1603	HG11	VAL	163	−34.966	−21.288	−6.606
ATOM	1604	HA	VAL	163	−33.471	−19.016	−5.111
ATOM	1605	H7	VAL	163	−32.693	−20.044	−6.333
ATOM	1606	N	LYS	164	−30.548	−20.616	−4.871
ATOM	1607	CA	LYS	164	−29.338	−20.653	−4.047
ATOM	1608	C	LYS	164	−28.532	−19.378	−4.154
ATOM	1609	O	LYS	164	−28.138	−18.858	−3.122
ATOM	1610	CB	LYS	164	−28.468	−21.918	−4.311
ATOM	1611	CG	LYS	164	−27.744	−21.947	−5.688
ATOM	1612	CD	LYS	164	−27.049	−23.319	−5.917
ATOM	1613	CE	LYS	164	−26.334	−23.388	−7.295
ATOM	1614	NZ	LYS	164	−25.721	−24.72	−7.524
ATOM	1615	HB2	LYS	164	−27.701	−21.993	−3.521
ATOM	1616	HB1	LYS	164	−29.128	−22.797	−4.226
ATOM	1617	HG2	LYS	164	−26.984	−21.149	−5.724
ATOM	1618	HG1	LYS	164	−28.462	−21.78	−6.504
ATOM	1619	HD2	LYS	164	−27.806	−24.119	−5.872
ATOM	1620	HD1	LYS	164	−26.314	−23.496	−5.115
ATOM	1621	HE2	LYS	164	−25.557	−22.604	−7.337
ATOM	1622	HE1	LYS	164	−27.067	−23.18	−8.095
ATOM	1623	HZ3	LYS	164	−24.985	−24.964	−6.769
ATOM	1624	HZ2	LYS	164	−25.217	−24.773	−8.481
ATOM	1625	HZ1	LYS	164	−26.456	−25.514	−7.52
ATOM	1626	H	LYS	164	−30.608	−21.196	−5.683
ATOM	1627	HA	LYS	164	−29.67	−20.741	−2.996
ATOM	1628	N	ARG	165	−28.262	−18.832	−5.362
ATOM	1629	CA	ARG	165	−27.459	−17.61	−5.426
ATOM	1630	C	ARG	165	−28.212	−16.505	−4.726
ATOM	1631	O	ARG	165	−27.653	−15.882	−3.838
ATOM	1632	CB	ARG	165	−27.114	−17.155	−6.872
ATOM	1633	CG	ARG	165	−26.123	−18.094	−7.621
ATOM	1634	CD	ARG	165	−24.69	−18.109	−7.011
ATOM	1635	NE	ARG	165	−23.716	−18.768	−7.888
ATOM	1636	CZ	ARG	165	−22.431	−18.858	−7.615
ATOM	1637	NH1	ARG	165	−21.903	−18.379	−6.513
ATOM	1638	NH2	ARG	165	−21.639	−19.451	−8.477
ATOM	1639	HB2	ARG	165	−28.05	−17.089	−7.451
ATOM	1640	HB1	ARG	165	−26.678	−16.142	−6.834
ATOM	1641	HG2	ARG	165	−26.046	−17.722	−8.657
ATOM	1642	HG1	ARG	165	−26.522	−19.121	−7.659
ATOM	1643	HD2	ARG	165	−24.715	−18.643	−6.048
ATOM	1644	HD1	ARG	165	−24.384	−17.062	−6.853
ATOM	1645	HE	ARG	165	−24.071	−19.17	−8.771
ATOM	1646	HH21	ARG	165	−22.003	−19.84	−9.36
ATOM	1647	HH22	ARG	165	−20.628	−19.541	−8.3
ATOM	1648	HH11	ARG	165	−22.472	−17.908	−5.799
ATOM	1649	HH12	ARG	165	−20.893	−18.463	−6.329
ATOM	1650	H	ARG	165	−28.63	−19.227	−6.204
ATOM	1651	HA	ARG	165	−26.524	−17.765	−4.864
ATOM	1652	N	VAL	166	−29.486	−16.248	−5.093
ATOM	1653	CA	VAL	166	−30.238	−15.216	−4.379
ATOM	1654	C	VAL	166	−30.202	−15.537	−2.899
ATOM	1655	O	VAL	166	−30.078	−14.616	−2.106
ATOM	1656	CB	VAL	166	−31.69	−14.97	−4.888
ATOM	1657	CG1	VAL	166	−31.685	−14.471	−6.361
ATOM	1658	CG2	VAL	166	−32.595	−16.221	−4.742
ATOM	1659	HB	VAL	166	−32.13	−14.171	−4.266
ATOM	1660	HG23	VAL	166	−32.188	−17.047	−5.337
ATOM	1661	HG22	VAL	166	−33.609	−16.008	−5.108
ATOM	1662	HG21	VAL	166	−32.675	−16.534	−3.691
ATOM	1663	HG13	VAL	166	−31.121	−13.529	−6.449
ATOM	1664	HG12	VAL	166	−32.715	−14.292	−6.7
ATOM	1665	HG11	VAL	166	−31.235	−15.21	−7.039
ATOM	1666	H	VAL	166	−29.921	−16.776	−5.82
ATOM	1667	HA	VAL	166	−29.691	−14.272	−4.527
ATOM	1668	N	GLY	167	−30.274	−16.833	−2.512
ATOM	1669	CA	GLY	167	−30.096	−17.199	−1.108
ATOM	1670	C	GLY	167	−28.811	−16.625	−0.556
ATOM	1671	O	GLY	167	−28.815	−16.04	0.516
ATOM	1672	H	GLY	167	−30.424	−17.573	−3.173
ATOM	1673	HA1	GLY	167	−30.969	−16.869	−0.528
ATOM	1674	HA2	GLY	167	−30.024	−18.293	−0.999
ATOM	1675	N	ILE	168	−27.682	−16.791	−1.283
ATOM	1676	CA	ILE	168	−26.419	−16.231	−0.806
ATOM	1677	C	ILE	168	−26.53	−14.724	−0.751
ATOM	1678	O	ILE	168	−26.061	−14.146	0.217
ATOM	1679	CB	ILE	168	−25.181	−16.62	−1.675
ATOM	1680	CG1	ILE	168	−24.94	−18.161	−1.774
ATOM	1681	CG2	ILE	168	−23.901	−15.882	−1.182
ATOM	1682	CD1	ILE	168	−24.724	−18.886	−0.418
ATOM	1683	HB	ILE	168	−25.37	−16.264	−2.703
ATOM	1684	HG23	ILE	168	−23.983	−14.796	−1.346
ATOM	1685	HG22	ILE	168	−23.013	−16.23	−1.732
ATOM	1686	HG21	ILE	168	−23.736	−16.052	−0.108
ATOM	1687	HG12	ILE	168	−24.052	−18.338	−2.403
ATOM	1688	HG11	ILE	168	−25.785	−18.649	−2.281
ATOM	1689	HD13	ILE	168	−23.889	−18.446	0.145
ATOM	1690	HD12	ILE	168	−24.488	−19.947	−0.602
ATOM	1691	HD11	ILE	168	−25.632	−18.852	0.202
ATOM	1692	H	ILE	168	−27.713	−17.261	−2.167
ATOM	1693	HA	ILE	168	−26.248	−16.578	0.225
ATOM	1694	N	ILE	169	−27.124	−14.051	−1.762
ATOM	1695	CA	ILE	169	−27.171	−12.588	−1.717
ATOM	1696	C	ILE	169	−27.941	−12.17	−0.485
ATOM	1697	O	ILE	169	−27.404	−11.431	0.327
ATOM	1698	CB	ILE	169	−27.779	−11.917	−2.991
ATOM	1699	CG1	ILE	169	−26.751	−11.81	−4.161
ATOM	1700	CG2	ILE	169	−28.32	−10.49	−2.677
ATOM	1701	CD1	ILE	169	−26.183	−13.165	−4.655
ATOM	1702	HB	ILE	169	−28.645	−12.507	−3.323
ATOM	1703	HG23	ILE	169	−29.152	−10.5	−1.957
ATOM	1704	HG22	ILE	169	−28.702	−10.014	−3.589
ATOM	1705	HG21	ILE	169	−27.512	−9.866	−2.273
ATOM	1706	HG12	ILE	169	−25.91	−11.165	−3.854
ATOM	1707	HG11	ILE	169	−27.242	−11.337	−5.028
ATOM	1708	HD13	ILE	169	−25.486	−12.995	−5.491
ATOM	1709	HD12	ILE	169	−27.002	−13.801	−5.019
ATOM	1710	HD11	ILE	169	−25.633	−13.686	−3.858
ATOM	1711	H	ILE	169	−27.54	−14.544	−2.53
ATOM	1712	HA	ILE	169	−26.142	−12.208	−1.604
ATOM	1713	N	ILE	170	−29.212	−12.608	−0.337
ATOM	1714	CA	ILE	170	−30.013	−12.106	0.779
ATOM	1715	C	ILE	170	−29.301	−12.356	2.091
ATOM	1716	O	ILE	170	−29.264	−11.472	2.934
ATOM	1717	CB	ILE	170	−31.492	−12.601	0.802
ATOM	1718	CG1	ILE	170	−32.295	−11.851	1.908
ATOM	1719	CG2	ILE	170	−31.6	−14.137	1.009
ATOM	1720	CD1	ILE	170	−33.835	−11.925	1.718
ATOM	1721	HB	ILE	170	−31.924	−12.349	−0.182
ATOM	1722	HG23	ILE	170	−30.984	−14.657	0.27
ATOM	1723	HG22	ILE	170	−32.635	−14.484	0.878
ATOM	1724	HG21	ILE	170	−31.258	−14.433	2.012
ATOM	1725	HG12	ILE	170	−32.01	−10.788	1.928
ATOM	1726	HG11	ILE	170	−32.021	−12.28	2.882
ATOM	1727	HD13	ILE	170	−34.121	−11.543	0.726
ATOM	1728	HD12	ILE	170	−34.339	−11.31	2.48
ATOM	1729	HD11	ILE	170	−34.203	−12.956	1.819
ATOM	1730	H	ILE	170	−29.623	−13.224	−1.014
ATOM	1731	HA	ILE	170	−30.063	−11.018	0.62
ATOM	1732	N	SER	171	−28.707	−13.554	2.284
ATOM	1733	CA	SER	171	−27.971	−13.8	3.523
ATOM	1734	C	SER	171	−26.76	−12.898	3.612
ATOM	1735	O	SER	171	−26.492	−12.354	4.671
ATOM	1736	CB	SER	171	−27.505	−15.276	3.596
ATOM	1737	OG	SER	171	−28.668	−16.121	3.542
ATOM	1738	HB2	SER	171	−26.834	−15.494	2.748
ATOM	1739	HB1	SER	171	−26.954	−15.445	4.537
ATOM	1740	HG	SER	171	−28.454	−17.049	3.559
ATOM	1741	H	SER	171	−28.734	−14.274	1.583
ATOM	1742	HA	SER	171	−28.635	−13.61	4.382
ATOM	1743	N	CYS	172	−26.001	−12.734	2.506
ATOM	1744	CA	CYS	172	−24.781	−11.934	2.567
ATOM	1745	C	CYS	172	−25.097	−10.504	2.935
ATOM	1746	O	CYS	172	−24.436	−9.956	3.803
ATOM	1747	CB	CYS	172	−24.022	−11.942	1.213
ATOM	1748	SG	CYS	172	−22.526	−10.902	1.308
ATOM	1749	HG	CYS	172	−22.052	−11.386	2.056
ATOM	1750	HB2	CYS	172	−23.731	−12.97	0.943
ATOM	1751	HB1	CYS	172	−24.66	−11.536	0.415
ATOM	1752	H	CYS	172	−26.255	−13.163	1.637
ATOM	1753	HA	CYS	172	−24.12	−12.368	3.336
ATOM	1754	LPG2	CYS	172	−22.671	−10.259	1.472
ATOM	1755	LPG1	CYS	172	−22.169	−10.913	0.73
ATOM	1756	N	ILE	173	−26.097	−9.861	2.295
ATOM	1757	CA	ILE	173	−26.371	−8.469	2.647
ATOM	1758	C	ILE	173	−26.849	−8.4	4.08
ATOM	1759	O	ILE	173	−26.46	−7.472	4.771
ATOM	1760	CB	ILE	173	−27.297	−7.699	1.658
ATOM	1761	CG1	ILE	173	−28.763	−8.214	1.706
ATOM	1762	CG2	ILE	173	−26.692	−7.751	0.225
ATOM	1763	CD1	ILE	173	−29.69	−7.502	0.688
ATOM	1764	HB	ILE	173	−27.314	−6.644	1.983
ATOM	1765	HG23	ILE	173	−25.608	−7.569	0.242
ATOM	1766	HG22	ILE	173	−27.141	−6.987	−0.426
ATOM	1767	HG21	ILE	173	−26.859	−8.739	−0.225
ATOM	1768	HG12	ILE	173	−29.176	−8.059	2.717
ATOM	1769	HG11	ILE	173	−28.776	−9.29	1.499
ATOM	1770	HD13	ILE	173	−29.666	−6.416	0.865
ATOM	1771	HD12	ILE	173	−30.724	−7.855	0.799
ATOM	1772	HD11	ILE	173	−29.388	−7.708	−0.35
ATOM	1773	H	ILE	173	−26.651	−10.333	1.606
ATOM	1774	HA	ILE	173	−25.404	−7.937	2.622
ATOM	1775	N	TRP	174	−27.659	−9.36	4.585
ATOM	1776	CA	TRP	174	−27.962	−9.318	6.014
ATOM	1777	C	TRP	174	−26.668	−9.437	6.792
ATOM	1778	O	TRP	174	−26.506	−8.722	7.767
ATOM	1779	CB	TRP	174	−28.935	−10.412	6.524
ATOM	1780	CG	TRP	174	−30.364	−10.25	6.067
ATOM	1781	CD1	TRP	174	−31.09	−11.174	5.416
ATOM	1782	CD2	TRP	174	−31.266	−9.056	6.281
ATOM	1783	NE1	TRP	174	−32.297	−10.717	5.209
ATOM	1784	CE2	TRP	174	−32.446	−9.47	5.692
ATOM	1785	CE3	TRP	174	−31.16	−7.801	6.883
ATOM	1786	CZ2	TRP	174	−33.582	−8.664	5.649
ATOM	1787	CZ3	TRP	174	−32.284	−6.964	6.823
ATOM	1788	CH2	TRP	174	−33.482	−7.396	6.232
ATOM	1789	H	TRP	174	−28.007	−10.121	4.03
ATOM	1790	HB2	TRP	174	−28.967	−10.374	7.625
ATOM	1791	HB1	TRP	174	−28.545	−11.399	6.232
ATOM	1792	HD1	TRP	174	−30.729	−12.159	5.119
ATOM	1793	HE1	TRP	174	−33.053	−11.246	4.754
ATOM	1794	HE3	TRP	174	−30.256	−7.48	7.386
ATOM	1795	HZ2	TRP	174	−34.498	−9.01	5.184
ATOM	1796	HZ3	TRP	174	−32.227	−5.965	7.243
ATOM	1797	HH2	TRP	174	−34.348	−6.744	6.225
ATOM	1798	HA	TRP	174	−28.402	−8.336	6.234
ATOM	1799	N	ALA	175	−25.715	−10.312	6.402
ATOM	1800	CA	ALA	175	−24.449	−10.352	7.134
ATOM	1801	C	ALA	175	−23.794	−8.986	7.096
ATOM	1802	O	ALA	175	−23.28	−8.541	8.111
ATOM	1803	CB	ALA	175	−23.469	−11.419	6.582
ATOM	1804	HB3	ALA	175	−23.158	−11.178	5.556
ATOM	1805	HB2	ALA	175	−23.95	−12.409	6.583
ATOM	1806	HB1	ALA	175	−22.568	−11.464	7.214
ATOM	1807	H	ALA	175	−25.85	−10.917	5.613
ATOM	1808	HA	ALA	175	−24.673	−10.613	8.182
ATOM	1809	N	ALA	176	−23.811	−8.289	5.936
ATOM	1810	CA	ALA	176	−23.255	−6.936	5.897
ATOM	1811	C	ALA	176	−23.96	−6.064	6.917
ATOM	1812	O	ALA	176	−23.315	−5.275	7.591
ATOM	1813	CB	ALA	176	−23.366	−6.285	4.494
ATOM	1814	HB3	ALA	176	−24.414	−6.081	4.232
ATOM	1815	HB2	ALA	176	−22.931	−6.95	3.731
ATOM	1816	HB1	ALA	176	−22.813	−5.334	4.481
ATOM	1817	H	ALA	176	−24.218	−8.677	5.105
ATOM	1818	HA	ALA	176	−22.185	−7.011	6.145
ATOM	1819	N	CYS	177	−25.298	−6.198	7.059
ATOM	1820	CA	CYS	177	−25.988	−5.451	8.108
ATOM	1821	C	CYS	177	−25.452	−5.867	9.459
ATOM	1822	O	CYS	177	−25.147	−5.009	10.274
ATOM	1823	CB	CYS	177	−27.525	−5.666	8.127
ATOM	1824	SG	CYS	177	−28.33	−5.095	6.592
ATOM	1825	HG	CYS	177	−27.911	−5.725	5.931
ATOM	1826	HB2	CYS	177	−27.792	−6.718	8.294
ATOM	1827	HB1	CYS	177	−27.934	−5.084	8.965
ATOM	1828	H	CYS	177	−25.816	−6.839	6.488
ATOM	1829	HA	CYS	177	−25.8	−4.377	7.971
ATOM	1830	LPG2	CYS	177	−28.179	−4.447	6.455
ATOM	1831	LPG1	CYS	177	−29.005	−5.169	6.619
ATOM	1832	N	THR	178	−25.343	−7.188	9.722
ATOM	1833	CA	THR	178	−24.892	−7.632	11.037
ATOM	1834	C	THR	178	−23.567	−7.001	11.385
ATOM	1835	O	THR	178	−23.438	−6.49	12.488
ATOM	1836	CB	THR	178	−24.759	−9.178	11.106
ATOM	1837	OG1	THR	178	−26.025	−9.737	10.713
ATOM	1838	CG2	THR	178	−24.376	−9.656	12.534
ATOM	1839	HB	THR	178	−23.976	−9.501	10.4
ATOM	1840	HG22	THR	178	−24.307	−10.754	12.559
ATOM	1841	HG21	THR	178	−25.14	−9.337	13.258
ATOM	1842	HG23	THR	178	−23.402	−9.245	12.841
ATOM	1843	HG1	THR	178	−26.024	−10.689	10.69
ATOM	1844	H	THR	178	−25.597	−7.88	9.042
ATOM	1845	HA	THR	178	−25.652	−7.321	11.773
ATOM	1846	N	VAL	179	−22.562	−7.022	10.479
ATOM	1847	CA	VAL	179	−21.272	−6.459	10.869
ATOM	1848	C	VAL	179	−21.463	−4.986	11.143
ATOM	1849	O	VAL	179	−20.94	−4.525	12.143
ATOM	1850	CB	VAL	179	−20.049	−6.723	9.939
ATOM	1851	CG1	VAL	179	−19.871	−8.242	9.658
ATOM	1852	CG2	VAL	179	−20.106	−5.917	8.617
ATOM	1853	HB	VAL	179	−19.146	−6.379	10.477
ATOM	1854	HG23	VAL	179	−21.01	−6.183	8.058
ATOM	1855	HG22	VAL	179	−19.229	−6.143	7.991
ATOM	1856	HG21	VAL	179	−20.113	−4.835	8.814
ATOM	1857	HG13	VAL	179	−19.831	−8.807	10.602
ATOM	1858	HG12	VAL	179	−18.932	−8.42	9.111
ATOM	1859	HG11	VAL	179	−20.698	−8.635	9.049
ATOM	1860	H	VAL	179	−22.693	−7.396	9.557
ATOM	1861	HA	VAL	179	−21.01	−6.94	11.827
ATOM	1862	N	SER	180	−22.212	−4.218	10.318
ATOM	1863	CA	SER	180	−22.416	−2.81	10.664
ATOM	1864	C	SER	180	−22.952	−2.71	12.075
ATOM	1865	O	SER	180	−22.488	−1.883	12.845
ATOM	1866	CB	SER	180	−23.395	−2.068	9.722
ATOM	1867	OG	SER	180	−23.515	−0.705	10.172
ATOM	1868	HB2	SER	180	−22.988	−2.096	8.7
ATOM	1869	HB1	SER	180	−24.379	−2.566	9.73
ATOM	1870	HG	SER	180	−24.116	−0.186	9.648
ATOM	1871	H	SER	180	−22.651	−4.595	9.497
ATOM	1872	HA	SER	180	−21.444	−2.295	10.603
ATOM	1873	N	GLY	181	−23.93	−3.57	12.439
ATOM	1874	CA	GLY	181	−24.406	−3.571	13.818
ATOM	1875	C	GLY	181	−23.257	−3.793	14.772
ATOM	1876	O	GLY	181	−23.18	−3.098	15.771
ATOM	1877	H	GLY	181	−24.318	−4.234	11.79
ATOM	1878	HA1	GLY	181	−24.896	−2.608	14.034
ATOM	1879	HA2	GLY	181	−25.14	−4.376	13.985
ATOM	1880	N	ILE	182	−22.349	−4.755	14.494
ATOM	1881	CA	ILE	182	−21.218	−4.97	15.4
ATOM	1882	C	ILE	182	−20.38	−3.71	15.445
ATOM	1883	O	ILE	182	−20.051	−3.257	16.53
ATOM	1884	CB	ILE	182	−20.341	−6.207	15.027
ATOM	1885	CG1	ILE	182	−21.175	−7.52	15.168
ATOM	1886	CG2	ILE	182	−19.058	−6.254	15.909
ATOM	1887	CD1	ILE	182	−20.462	−8.788	14.623
ATOM	1888	HB	ILE	182	−20.017	−6.096	13.98
ATOM	1889	HG23	ILE	182	−18.452	−5.345	15.78
ATOM	1890	HG22	ILE	182	−18.412	−7.1	15.636
ATOM	1891	HG21	ILE	182	−19.328	−6.345	16.972
ATOM	1892	HG12	ILE	182	−22.119	−7.423	14.61
ATOM	1893	HG11	ILE	182	−21.434	−7.683	16.227
ATOM	1894	HD13	ILE	182	−20.113	−8.623	13.592
ATOM	1895	HD12	ILE	182	−21.164	−9.637	14.618
ATOM	1896	HD11	ILE	182	−19.604	−9.072	15.248
ATOM	1897	H	ILE	182	−22.425	−5.293	13.652
ATOM	1898	HA	ILE	182	−21.616	−5.159	16.408
ATOM	1899	N	LEU	183	−20.018	−3.135	14.275
ATOM	1900	CA	LEU	183	−19.164	−1.947	14.264
ATOM	1901	C	LEU	183	−19.724	−0.908	15.208
ATOM	1902	O	LEU	183	−18.966	−0.39	16.012
ATOM	1903	CB	LEU	183	−19.021	−1.31	12.848
ATOM	1904	CG	LEU	183	−17.877	−1.904	11.968
ATOM	1905	CD1	LEU	183	−17.905	−3.452	11.838
ATOM	1906	CD2	LEU	183	−17.939	−1.282	10.545
ATOM	1907	HB2	LEU	183	−19.985	−1.375	12.326
ATOM	1908	HB1	LEU	183	−18.792	−0.237	12.967
ATOM	1909	HG	LEU	183	−16.914	−1.626	12.435
ATOM	1910	HD13	LEU	183	−17.889	−3.948	12.82
ATOM	1911	HD12	LEU	183	−17.024	−3.796	11.274
ATOM	1912	HD11	LEU	183	−18.799	−3.769	11.287
ATOM	1913	HD23	LEU	183	−18.847	−1.62	10.024
ATOM	1914	HD22	LEU	183	−17.065	−1.583	9.947
ATOM	1915	HD21	LEU	183	−17.966	−0.185	10.6
ATOM	1916	H	LEU	183	−20.328	−3.523	13.406
ATOM	1917	HA	LEU	183	−18.164	−2.225	14.637
ATOM	1918	N	PHE	184	−21.032	−0.573	15.14
ATOM	1919	CA	PHE	184	−21.548	0.436	16.065
ATOM	1920	C	PHE	184	−21.742	−0.126	17.451
ATOM	1921	O	PHE	184	−21.452	0.591	18.392
ATOM	1922	CB	PHE	184	−22.883	1.074	15.62
ATOM	1923	CG	PHE	184	−23.357	2.027	16.732
ATOM	1924	CD1	PHE	184	−22.726	3.264	16.916
ATOM	1925	CD2	PHE	184	−24.407	1.663	17.582
ATOM	1926	CE1	PHE	184	−23.122	4.117	17.95
ATOM	1927	CE2	PHE	184	−24.779	2.497	18.64
ATOM	1928	CZ	PHE	184	−24.13	3.72	18.833
ATOM	1929	HB2	PHE	184	−22.713	1.626	14.684
ATOM	1930	HB1	PHE	184	−23.628	0.285	15.432
ATOM	1931	HD1	PHE	184	−21.923	3.569	16.253
ATOM	1932	HD2	PHE	184	−24.936	0.727	17.433
ATOM	1933	HE1	PHE	184	−22.645	5.085	18.068
ATOM	1934	HE2	PHE	184	−25.572	2.192	19.312
ATOM	1935	HZ	PHE	184	−24.406	4.357	19.666
ATOM	1936	H	PHE	184	−21.652	−1.018	14.487
ATOM	1937	HA	PHE	184	−20.813	1.257	16.136
ATOM	1938	N	ILE	185	−22.226	−1.371	17.65
ATOM	1939	CA	ILE	185	−22.337	−1.88	19.022
ATOM	1940	C	ILE	185	−21	−1.669	19.701
ATOM	1941	O	ILE	185	−20.977	−1.304	20.866
ATOM	1942	CB	ILE	185	−22.8	−3.366	19.082
ATOM	1943	CG1	ILE	185	−24.31	−3.47	18.696
ATOM	1944	CG2	ILE	185	−22.537	−3.982	20.487
ATOM	1945	CD1	ILE	185	−24.738	−4.896	18.256
ATOM	1946	HB	ILE	185	−22.187	−3.924	18.359
ATOM	1947	HG23	ILE	185	−21.461	−3.997	20.719
ATOM	1948	HG22	ILE	185	−22.892	−5.021	20.542
ATOM	1949	HG21	ILE	185	−23.054	−3.395	21.262
ATOM	1950	HG12	ILE	185	−24.539	−2.79	17.861
ATOM	1951	HG11	ILE	185	−24.93	−3.149	19.549
ATOM	1952	HD13	ILE	185	−24.128	−5.235	17.404
ATOM	1953	HD12	ILE	185	−25.794	−4.888	17.941
ATOM	1954	HD11	ILE	185	−24.636	−5.623	19.074
ATOM	1955	H	ILE	185	−22.463	−1.956	16.873
ATOM	1956	HA	ILE	185	−23.076	−1.264	19.562
ATOM	1957	N	ILE	186	−19.87	−1.848	18.981
ATOM	1958	CA	ILE	186	−18.588	−1.405	19.527
ATOM	1959	C	ILE	186	−18.595	0.096	19.307
ATOM	1960	O	ILE	186	−17.913	0.572	18.413
ATOM	1961	CB	ILE	186	−17.396	−2.141	18.838
ATOM	1962	CG1	ILE	186	−17.556	−3.688	18.993
ATOM	1963	CG2	ILE	186	−16.039	−1.657	19.429
ATOM	1964	CD1	ILE	186	−16.494	−4.505	18.208
ATOM	1965	HB	ILE	186	−17.419	−1.895	17.762
ATOM	1966	HG23	ILE	186	−15.954	−0.561	19.411
ATOM	1967	HG22	ILE	186	−15.193	−2.054	18.851
ATOM	1968	HG21	ILE	186	−15.939	−1.988	20.474
ATOM	1969	HG12	ILE	186	−18.54	−4.005	18.616
ATOM	1970	HG11	ILE	186	−17.508	−3.961	20.059
ATOM	1971	HD13	ILE	186	−16.464	−4.184	17.155
ATOM	1972	HD12	ILE	186	−16.748	−5.576	18.237
ATOM	1973	HD11	ILE	186	−15.492	−4.388	18.646
ATOM	1974	H	ILE	186	−19.907	−2.148	18.023
ATOM	1975	HA	ILE	186	−18.523	−1.615	20.607
ATOM	1976	N	TYR	187	−19.371	0.885	20.09
ATOM	1977	CA	TYR	187	−19.538	2.31	19.778
ATOM	1978	C	TYR	187	−18.314	3.137	20.117
ATOM	1979	O	TYR	187	−18.425	4.124	20.826
ATOM	1980	CB	TYR	187	−20.866	2.933	20.32
ATOM	1981	CG	TYR	187	−21.035	2.906	21.848
ATOM	1982	CD1	TYR	187	−20.654	3.999	22.638
ATOM	1983	CD2	TYR	187	−21.607	1.793	22.476
ATOM	1984	CE1	TYR	187	−20.744	3.94	24.031
ATOM	1985	CE2	TYR	187	−21.695	1.73	23.869
ATOM	1986	CZ	TYR	187	−21.257	2.797	24.656
ATOM	1987	OH	TYR	187	−21.342	2.702	26.049
ATOM	1988	HB1	TYR	187	−20.933	3.973	19.97
ATOM	1989	HB2	TYR	187	−21.735	2.413	19.895
ATOM	1990	HD1	TYR	187	−20.289	4.91	22.177
ATOM	1991	HD2	TYR	187	−21.995	0.969	21.886
ATOM	1992	HE1	TYR	187	−20.414	4.79	24.62
ATOM	1993	HE2	TYR	187	−22.108	0.847	24.347
ATOM	1994	HH	TYR	187	−21.028	3.469	26.513
ATOM	1995	H	TYR	187	−19.879	0.491	20.854
ATOM	1996	HA	TYR	187	−19.622	2.408	18.681
ATOM	1997	N	SER	188	−17.116	2.807	19.585
ATOM	1998	CA	SER	188	−15.989	3.731	19.695
ATOM	1999	C	SER	188	−16.268	4.762	18.624
ATOM	2000	O	SER	188	−15.666	4.693	17.564
ATOM	2001	CB	SER	188	−14.641	2.998	19.483
ATOM	2002	OG	SER	188	−13.573	3.96	19.551
ATOM	2003	HB2	SER	188	−14.522	2.237	20.273
ATOM	2004	HB1	SER	188	−14.655	2.485	18.508
ATOM	2005	HG	SER	188	−12.714	3.57	19.428
ATOM	2006	H	SER	188	−17.019	2.013	18.985
ATOM	2007	HA	SER	188	−15.942	4.211	20.687
ATOM	2008	N	ASP	189	−17.221	5.687	18.894
ATOM	2009	CA	ASP	189	−17.799	6.518	17.836
ATOM	2010	C	ASP	189	−16.795	6.904	16.774
ATOM	2011	O	ASP	189	−17	6.566	15.622
ATOM	2012	CB	ASP	189	−18.507	7.791	18.383
ATOM	2013	CG	ASP	189	−19.551	8.271	17.408
ATOM	2014	OD1	ASP	189	−19.188	9.049	16.489
ATOM	2015	OD2	ASP	189	−20.739	7.87	17.555
ATOM	2016	HB2	ASP	189	−19.019	7.574	19.33
ATOM	2017	HB1	ASP	189	−17.785	8.596	18.583
ATOM	2018	H	ASP	189	−17.659	5.704	19.797
ATOM	2019	HA	ASP	189	−18.578	5.893	17.365
ATOM	2020	N	SER	190	−15.69	7.603	17.11
ATOM	2021	CA	SER	190	−14.79	8.07	16.057
ATOM	2022	C	SER	190	−14.255	6.943	15.2
ATOM	2023	O	SER	190	−14.316	7.05	13.985
ATOM	2024	CB	SER	190	−13.597	8.862	16.647
ATOM	2025	OG	SER	190	−14.117	9.944	17.44
ATOM	2026	HB2	SER	190	−12.985	8.194	17.276
ATOM	2027	HB1	SER	190	−12.97	9.252	15.826
ATOM	2028	HG	SER	190	−13.435	10.483	17.829
ATOM	2029	H	SER	190	−15.499	7.848	18.062
ATOM	2030	HA	SER	190	−15.358	8.762	15.414
ATOM	2031	N	SER	191	−13.71	5.852	15.782
ATOM	2032	CA	SER	191	−13.154	4.803	14.928
ATOM	2033	C	SER	191	−14.29	4.072	14.255
ATOM	2034	O	SER	191	−14.243	3.916	13.045
ATOM	2035	CB	SER	191	−12.263	3.79	15.689
ATOM	2036	OG	SER	191	−13.054	3.048	16.629
ATOM	2037	H	SER	191	−13.715	5.724	16.776
ATOM	2038	HB2	SER	191	−11.459	4.336	16.211
ATOM	2039	HB1	SER	191	−11.807	3.098	14.959
ATOM	2040	HG	SER	191	−12.546	2.387	17.089
ATOM	2041	HA	SER	191	−12.516	5.273	14.161
ATOM	2042	N	ALA	192	−15.314	3.635	15.026
ATOM	2043	CA	ALA	192	−16.475	2.98	14.421
ATOM	2044	C	ALA	192	−16.946	3.782	13.227
ATOM	2045	O	ALA	192	−17.179	3.216	12.17
ATOM	2046	CB	ALA	192	−17.642	2.838	15.435
ATOM	2047	HB3	ALA	192	−17.954	3.825	15.809
ATOM	2048	HB2	ALA	192	−17.328	2.223	16.292
ATOM	2049	HB1	ALA	192	−18.507	2.353	14.955
ATOM	2050	H	ALA	192	−15.294	3.768	16.021
ATOM	2051	HA	ALA	192	−16.187	1.966	14.101
ATOM	2052	N	VAL	193	−17.073	5.117	13.39
ATOM	2053	CA	VAL	193	−17.467	5.976	12.277
ATOM	2054	C	VAL	193	−16.458	5.865	11.16
ATOM	2055	O	VAL	193	−16.858	5.633	10.032
ATOM	2056	CB	VAL	193	−17.622	7.469	12.707
ATOM	2057	CG1	VAL	193	−17.508	8.446	11.504
ATOM	2058	CG2	VAL	193	−18.971	7.674	13.455
ATOM	2059	H	VAL	193	−16.865	5.538	14.274
ATOM	2060	HB	VAL	193	−16.797	7.746	13.384
ATOM	2061	HG13	VAL	193	−16.495	8.449	11.072
ATOM	2062	HG12	VAL	193	−17.728	9.47	11.834
ATOM	2063	HG11	VAL	193	−18.219	8.165	10.716
ATOM	2064	HG23	VAL	193	−19.819	7.46	12.787
ATOM	2065	HG22	VAL	193	−19.06	8.711	13.815
ATOM	2066	HG21	VAL	193	−19.055	7.002	14.321
ATOM	2067	HA	VAL	193	−18.437	5.625	11.889
ATOM	2068	N	ILE	194	−15.149	6.05	11.427
ATOM	2069	CA	ILE	194	−14.192	6.052	10.32
ATOM	2070	C	ILE	194	−14.301	4.744	9.567
ATOM	2071	O	ILE	194	−14.502	4.773	8.361
ATOM	2072	CB	ILE	194	−12.732	6.335	10.791
ATOM	2073	CG1	ILE	194	−12.598	7.824	11.243
ATOM	2074	CG2	ILE	194	−11.708	5.995	9.668
ATOM	2075	CD1	ILE	194	−11.358	8.092	12.138
ATOM	2076	H	ILE	194	−14.837	6.2	12.369
ATOM	2077	HB	ILE	194	−12.522	5.672	11.646
ATOM	2078	HG12	ILE	194	−13.484	8.127	11.822
ATOM	2079	HG11	ILE	194	−12.555	8.476	10.355
ATOM	2080	HG23	ILE	194	−11.742	4.926	9.406
ATOM	2081	HG22	ILE	194	−10.679	6.216	9.984
ATOM	2082	HG21	ILE	194	−11.929	6.581	8.763
ATOM	2083	HD13	ILE	194	−11.385	7.449	13.032
ATOM	2084	HD12	ILE	194	−11.358	9.143	12.47
ATOM	2085	HD11	ILE	194	−10.417	7.909	11.599
ATOM	2086	HA	ILE	194	−14.475	6.857	9.62
ATOM	2087	N	ILE	195	−14.164	3.583	10.247
ATOM	2088	CA	ILE	195	−14.233	2.32	9.511
ATOM	2089	C	ILE	195	−15.58	2.21	8.827
ATOM	2090	O	ILE	195	−15.624	1.856	7.659
ATOM	2091	CB	ILE	195	−13.858	1.031	10.313
ATOM	2092	CG1	ILE	195	−13.878	−0.253	9.424
ATOM	2093	CG2	ILE	195	−14.774	0.786	11.544
ATOM	2094	CD1	ILE	195	−12.932	−0.206	8.193
ATOM	2095	HB	ILE	195	−12.831	1.167	10.695
ATOM	2096	HG23	ILE	195	−14.719	1.619	12.25
ATOM	2097	HG22	ILE	195	−14.465	−0.121	12.086
ATOM	2098	HG21	ILE	195	−15.818	0.659	11.235
ATOM	2099	HG12	ILE	195	−14.905	−0.45	9.081
ATOM	2100	HG11	ILE	195	−13.564	−1.112	10.042
ATOM	2101	HD13	ILE	195	−13.295	0.496	7.431
ATOM	2102	HD12	ILE	195	−12.878	−1.202	7.725
ATOM	2103	HD11	ILE	195	−11.917	0.09	8.5
ATOM	2104	H	ILE	195	−14.011	3.588	11.237
ATOM	2105	HA	ILE	195	−13.455	2.415	8.741
ATOM	2106	N	CYS	196	−16.698	2.52	9.522
ATOM	2107	CA	CYS	196	−18.014	2.392	8.894
ATOM	2108	C	CYS	196	−18.091	3.231	7.639
ATOM	2109	O	CYS	196	−18.418	2.719	6.58
ATOM	2110	CB	CYS	196	−19.138	2.826	9.878
ATOM	2111	SG	CYS	196	−20.788	2.833	9.103
ATOM	2112	HG	CYS	196	−20.946	1.839	9.078
ATOM	2113	HB2	CYS	196	−19.155	2.167	10.761
ATOM	2114	HB1	CYS	196	−18.96	3.854	10.221
ATOM	2115	H	CYS	196	−16.639	2.851	10.468
ATOM	2116	HA	CYS	196	−18.177	1.338	8.621
ATOM	2117	LPG2	CYS	196	−20.778	3.106	8.481
ATOM	2118	LPG1	CYS	196	−21.249	3.156	9.483
ATOM	2119	N	LEU	197	−17.795	4.541	7.738
ATOM	2120	CA	LEU	197	−17.967	5.429	6.589
ATOM	2121	C	LEU	197	−17.136	4.938	5.424
ATOM	2122	O	LEU	197	−17.654	4.908	4.317
ATOM	2123	CB	LEU	197	−17.64	6.907	6.963
ATOM	2124	CG	LEU	197	−18.84	7.712	7.571
ATOM	2125	CD1	LEU	197	−19.684	8.38	6.449
ATOM	2126	CD2	LEU	197	−19.768	6.898	8.521
ATOM	2127	HB2	LEU	197	−16.781	6.92	7.653
ATOM	2128	HB1	LEU	197	−17.302	7.431	6.056
ATOM	2129	HG	LEU	197	−18.42	8.535	8.175
ATOM	2130	HD13	LEU	197	−19.084	9.134	5.916
ATOM	2131	HD12	LEU	197	−20.565	8.891	6.869
ATOM	2132	HD11	LEU	197	−20.016	7.626	5.721
ATOM	2133	HD23	LEU	197	−20.348	6.136	7.982
ATOM	2134	HD22	LEU	197	−20.49	7.571	9.01
ATOM	2135	HD21	LEU	197	−19.192	6.401	9.312
ATOM	2136	H	LEU	197	−17.445	4.905	8.602
ATOM	2137	HA	LEU	197	−19.011	5.367	6.245
ATOM	2138	N	ILE	198	−15.856	4.543	5.609
ATOM	2139	CA	ILE	198	−15.098	4.087	4.443
ATOM	2140	C	ILE	198	−15.623	2.762	3.926
ATOM	2141	O	ILE	198	−15.914	2.683	2.742
ATOM	2142	CB	ILE	198	−13.542	4.083	4.587
ATOM	2143	CG1	ILE	198	−12.867	3.895	3.19
ATOM	2144	CG2	ILE	198	−13.035	3.006	5.584
ATOM	2145	CD1	ILE	198	−11.317	3.981	3.226
ATOM	2146	HB	ILE	198	−13.257	5.073	4.983
ATOM	2147	HG23	ILE	198	−13.614	3.055	6.51
ATOM	2148	HG22	ILE	198	−11.982	3.174	5.852
ATOM	2149	HG21	ILE	198	−13.131	1.997	5.157
ATOM	2150	HG12	ILE	198	−13.219	4.683	2.505
ATOM	2151	HG11	ILE	198	−13.156	2.923	2.758
ATOM	2152	HD13	ILE	198	−10.995	4.906	3.728
ATOM	2153	HD12	ILE	198	−10.919	3.985	2.199
ATOM	2154	HD11	ILE	198	−10.879	3.118	3.749
ATOM	2155	H	ILE	198	−15.434	4.561	6.519
ATOM	2156	HA	ILE	198	−15.293	4.838	3.664
ATOM	2157	N	THR	199	−15.742	1.7	4.76
ATOM	2158	CA	THR	199	−16.021	0.368	4.209
ATOM	2159	C	THR	199	−17.499	0.072	4.087
ATOM	2160	O	THR	199	−17.885	−0.553	3.114
ATOM	2161	CB	THR	199	−15.268	−0.762	4.969
ATOM	2162	OG1	THR	199	−15.136	−1.896	4.089
ATOM	2163	CG2	THR	199	−15.99	−1.217	6.264
ATOM	2164	HB	THR	199	−14.259	−0.387	5.214
ATOM	2165	HG22	THR	199	−15.364	−1.929	6.823
ATOM	2166	HG21	THR	199	−16.925	−1.723	5.993
ATOM	2167	HG23	THR	199	−16.228	−0.372	6.919
ATOM	2168	HG1	THR	199	−14.641	−2.615	4.471
ATOM	2169	H	THR	199	−15.616	1.801	5.751
ATOM	2170	HA	THR	199	−15.604	0.325	3.19
ATOM	2171	N	MET	200	−18.356	0.496	5.044
ATOM	2172	CA	MET	200	−19.789	0.222	4.919
ATOM	2173	C	MET	200	−20.463	1.205	3.981
ATOM	2174	O	MET	200	−21.63	0.981	3.697
ATOM	2175	CB	MET	200	−20.496	0.276	6.304
ATOM	2176	CG	MET	200	−19.957	−0.757	7.335
ATOM	2177	SD	MET	200	−20.639	−2.432	7.087
ATOM	2178	CE	MET	200	−19.317	−3.359	6.254
ATOM	2179	HB2	MET	200	−20.356	1.291	6.698
ATOM	2180	HB1	MET	200	−21.58	0.138	6.194
ATOM	2181	HG2	MET	200	−20.314	−0.465	8.334
ATOM	2182	HG1	MET	200	−18.859	−0.788	7.36
ATOM	2183	HE3	MET	200	−19.013	−2.859	5.324
ATOM	2184	HE2	MET	200	−19.696	−4.362	6.008
ATOM	2185	HE1	MET	200	−18.455	−3.456	6.93
ATOM	2186	H	MET	200	−18.039	1.061	5.809
ATOM	2187	HA	MET	200	−19.958	−0.784	4.502
ATOM	2188	LPD2	MET	200	−21.196	−2.408	6.698
ATOM	2189	LPD1	MET	200	−20.792	−2.718	7.683
ATOM	2190	N	PHE	201	−19.8	2.285	3.494
ATOM	2191	CA	PHE	201	−20.487	3.26	2.641
ATOM	2192	C	PHE	201	−19.601	3.665	1.475
ATOM	2193	O	PHE	201	−19.945	3.344	0.348
ATOM	2194	CB	PHE	201	−20.956	4.44	3.542
ATOM	2195	CG	PHE	201	−21.997	5.38	2.905
ATOM	2196	CD1	PHE	201	−23.266	5.537	3.477
ATOM	2197	CD2	PHE	201	−21.687	6.118	1.756
ATOM	2198	CE1	PHE	201	−24.16	6.49	2.979
ATOM	2199	CE2	PHE	201	−22.588	7.052	1.237
ATOM	2200	CZ	PHE	201	−23.818	7.26	1.865
ATOM	2201	H	PHE	201	−18.852	2.481	3.748
ATOM	2202	HB2	PHE	201	−20.107	5.063	3.848
ATOM	2203	HB1	PHE	201	−21.377	4.001	4.46
ATOM	2204	HD1	PHE	201	−23.565	4.924	4.321
ATOM	2205	HD2	PHE	201	−20.739	5.977	1.257
ATOM	2206	HE1	PHE	201	−25.123	6.64	3.454
ATOM	2207	HE2	PHE	201	−22.331	7.62	0.348
ATOM	2208	HZ	PHE	201	−24.504	8.014	1.49
ATOM	2209	HA	PHE	201	−21.4	2.824	2.199
ATOM	2210	N	PHE	202	−18.462	4.371	1.677
ATOM	2211	CA	PHE	202	−17.729	4.896	0.522
ATOM	2212	C	PHE	202	−17.356	3.784	−0.433
ATOM	2213	O	PHE	202	−17.573	3.933	−1.626
ATOM	2214	CB	PHE	202	−16.426	5.663	0.89
ATOM	2215	CG	PHE	202	−16.566	6.82	1.898
ATOM	2216	CD1	PHE	202	−15.409	7.313	2.514
ATOM	2217	CD2	PHE	202	−17.794	7.409	2.226
ATOM	2218	CE1	PHE	202	−15.478	8.33	3.471
ATOM	2219	CE2	PHE	202	−17.868	8.443	3.163
ATOM	2220	CZ	PHE	202	−16.71	8.904	3.792
ATOM	2221	HB2	PHE	202	−15.707	4.935	1.292
ATOM	2222	HB1	PHE	202	−15.991	6.088	−0.029
ATOM	2223	HD1	PHE	202	−14.438	6.907	2.249
ATOM	2224	HD2	PHE	202	−18.71	7.082	1.758
ATOM	2225	HE1	PHE	202	−14.574	8.677	3.962
ATOM	2226	HE2	PHE	202	−18.829	8.889	3.399
ATOM	2227	HZ	PHE	202	−16.766	9.704	4.524
ATOM	2228	H	PHE	202	−18.122	4.581	2.597
ATOM	2229	HA	PHE	202	−18.393	5.584	−0.028
ATOM	2230	N	THR	203	−16.788	2.661	0.059
ATOM	2231	CA	THR	203	−16.398	1.592	−0.86
ATOM	2232	C	THR	203	−17.57	1.138	−1.701
ATOM	2233	O	THR	203	−17.376	0.879	−2.878
ATOM	2234	CB	THR	203	−15.785	0.388	−0.093
ATOM	2235	OG1	THR	203	−14.645	0.887	0.631
ATOM	2236	CG2	THR	203	−15.336	−0.744	−1.058
ATOM	2237	HB	THR	203	−16.54	0	0.613
ATOM	2238	HG22	THR	203	−14.897	−1.575	−0.485
ATOM	2239	HG21	THR	203	−14.578	−0.362	−1.758
ATOM	2240	HG23	THR	203	−16.181	−1.142	−1.639
ATOM	2241	HG1	THR	203	−14.2	0.216	1.139
ATOM	2242	H	THR	203	−16.607	2.553	1.041
ATOM	2243	HA	THR	203	−15.617	1.991	−1.527
ATOM	2244	N	MET	204	−18.795	1.03	−1.141
ATOM	2245	CA	MET	204	−19.923	0.579	−1.958
ATOM	2246	C	MET	204	−20.197	1.594	−3.047
ATOM	2247	O	MET	204	−20.384	1.199	−4.188
ATOM	2248	CB	MET	204	−21.234	0.361	−1.15
ATOM	2249	CG	MET	204	−21.256	−0.958	−0.332
ATOM	2250	SD	MET	204	−20.007	−0.969	0.993
ATOM	2251	CE	MET	204	−18.779	−2.124	0.306
ATOM	2252	HB2	MET	204	−21.425	1.224	−0.491
ATOM	2253	HB1	MET	204	−22.065	0.296	−1.869
ATOM	2254	HG2	MET	204	−21.126	−1.828	−0.992
ATOM	2255	HG1	MET	204	−22.23	−1.065	0.167
ATOM	2256	HE3	MET	204	−18.428	−1.762	−0.67
ATOM	2257	HE2	MET	204	−19.233	−3.119	0.185
ATOM	2258	HE1	MET	204	−17.924	−2.201	0.994
ATOM	2259	H	MET	204	−18.95	1.295	−0.187
ATOM	2260	HA	MET	204	−19.658	−0.372	−2.448
ATOM	2261	LPD2	MET	204	−20.266	−1.199	1.577
ATOM	2262	LPD1	MET	204	−19.742	−0.352	1.09
ATOM	2263	N	LEU	205	−20.237	2.907	−2.726
ATOM	2264	CA	LEU	205	−20.531	3.893	−3.769
ATOM	2265	C	LEU	205	−19.397	3.899	−4.77
ATOM	2266	O	LEU	205	−19.66	3.878	−5.962
ATOM	2267	CB	LEU	205	−20.744	5.34	−3.229
ATOM	2268	CG	LEU	205	−22.142	5.637	−2.597
ATOM	2269	CD1	LEU	205	−23.291	5.669	−3.645
ATOM	2270	CD2	LEU	205	−22.494	4.659	−1.447
ATOM	2271	H	LEU	205	−20.035	3.212	−1.791
ATOM	2272	HB2	LEU	205	−20.613	6.049	−4.063
ATOM	2273	HB1	LEU	205	−19.951	5.555	−2.494
ATOM	2274	HG	LEU	205	−22.092	6.652	−2.161
ATOM	2275	HD13	LEU	205	−23.074	6.4	−4.439
ATOM	2276	HD12	LEU	205	−24.238	5.955	−3.163
ATOM	2277	HD11	LEU	205	−23.439	4.686	−4.108
ATOM	2278	HD23	LEU	205	−22.548	3.628	−1.823
ATOM	2279	HD22	LEU	205	−23.462	4.92	−0.991
ATOM	2280	HD21	LEU	205	−21.727	4.712	−0.665
ATOM	2281	HA	LEU	205	−21.431	3.571	−4.314
ATOM	2282	N	ALA	206	−18.124	3.932	−4.321
ATOM	2283	CA	ALA	206	−17.018	3.943	−5.278
ATOM	2284	C	ALA	206	−17.061	2.705	−6.147
ATOM	2285	O	ALA	206	−16.903	2.808	−7.355
ATOM	2286	CB	ALA	206	−15.649	3.996	−4.552
ATOM	2287	HB3	ALA	206	−15.521	3.112	−3.908
ATOM	2288	HB2	ALA	206	−15.588	4.9	−3.926
ATOM	2289	HB1	ALA	206	−14.829	4.019	−5.286
ATOM	2290	H	ALA	206	−17.926	3.942	−3.339
ATOM	2291	HA	ALA	206	−17.112	4.838	−5.916
ATOM	2292	N	LEU	207	−17.274	1.515	−5.544
ATOM	2293	CA	LEU	207	−17.317	0.292	−6.343
ATOM	2294	C	LEU	207	−18.45	0.405	−7.33
ATOM	2295	O	LEU	207	−18.223	0.209	−8.514
ATOM	2296	CB	LEU	207	−17.446	−0.965	−5.436
ATOM	2297	CG	LEU	207	−17.456	−2.33	−6.197
ATOM	2298	CD1	LEU	207	−16.975	−3.46	−5.242
ATOM	2299	CD2	LEU	207	−18.862	−2.698	−6.757
ATOM	2300	HB2	LEU	207	−16.571	−0.936	−4.765
ATOM	2301	HB1	LEU	207	−18.346	−0.889	−4.806
ATOM	2302	HG	LEU	207	−16.743	−2.285	−7.038
ATOM	2303	HD13	LEU	207	−15.936	−3.284	−4.922
ATOM	2304	HD12	LEU	207	−17.012	−4.442	−5.74
ATOM	2305	HD11	LEU	207	−17.611	−3.495	−4.346
ATOM	2306	HD23	LEU	207	−19.609	−2.685	−5.95
ATOM	2307	HD22	LEU	207	−18.849	−3.707	−7.198
ATOM	2308	HD21	LEU	207	−19.192	−2.009	−7.543
ATOM	2309	H	LEU	207	−17.42	1.457	−4.553
ATOM	2310	HA	LEU	207	−16.369	0.213	−6.903
ATOM	2311	N	MET	208	−19.684	0.718	−6.878
ATOM	2312	CA	MET	208	−20.783	0.806	−7.834
ATOM	2313	C	MET	208	−20.559	1.913	−8.834
ATOM	2314	O	MET	208	−21.022	1.767	−9.953
ATOM	2315	CB	MET	208	−22.176	0.965	−7.175
ATOM	2316	CG	MET	208	−22.606	−0.351	−6.478
ATOM	2317	SD	MET	208	−24.352	−0.192	−5.999
ATOM	2318	CE	MET	208	−24.15	0.534	−4.354
ATOM	2319	HB2	MET	208	−22.161	1.811	−6.47
ATOM	2320	HB1	MET	208	−22.915	1.189	−7.963
ATOM	2321	HG2	MET	208	−21.973	−0.583	−5.607
ATOM	2322	HG1	MET	208	−22.549	−1.194	−7.181
ATOM	2323	HE3	MET	208	−23.741	−0.231	−3.68
ATOM	2324	HE2	MET	208	−25.14	0.841	−4.005
ATOM	2325	HE1	MET	208	−23.482	1.406	−4.376
ATOM	2326	H	MET	208	−19.856	0.909	−5.908
ATOM	2327	HA	MET	208	−20.801	−0.13	−8.412
ATOM	2328	LPD2	MET	208	−24.664	−0.795	−5.973
ATOM	2329	LPD1	MET	208	−24.693	0.22	−6.418
ATOM	2330	N	ALA	209	−19.863	3.019	−8.499
ATOM	2331	CA	ALA	209	−19.571	4.01	−9.533
ATOM	2332	C	ALA	209	−18.69	3.365	−10.581
ATOM	2333	O	ALA	209	−18.991	3.455	−11.761
ATOM	2334	CB	ALA	209	−18.873	5.267	−8.952
ATOM	2335	HB3	ALA	209	−17.912	5.003	−8.487
ATOM	2336	HB2	ALA	209	−19.515	5.734	−8.19
ATOM	2337	HB1	ALA	209	−18.685	5.998	−9.754
ATOM	2338	H	ALA	209	−19.508	3.154	−7.571
ATOM	2339	HA	ALA	209	−20.518	4.332	−9.999
ATOM	2340	N	SER	210	−17.59	2.696	−10.17
ATOM	2341	CA	SER	210	−16.712	2.067	−11.158
ATOM	2342	C	SER	210	−17.457	1.005	−11.938
ATOM	2343	O	SER	210	−17.339	0.94	−13.152
ATOM	2344	CB	SER	210	−15.482	1.411	−10.479
ATOM	2345	OG	SER	210	−14.612	0.875	−11.491
ATOM	2346	HB2	SER	210	−14.945	2.173	−9.888
ATOM	2347	HB1	SER	210	−15.818	0.61	−9.798
ATOM	2348	HG	SER	210	−13.845	0.441	−11.131
ATOM	2349	H	SER	210	−17.373	2.612	−9.193
ATOM	2350	HA	SER	210	−16.346	2.838	−11.856
ATOM	2351	N	LEU	211	−18.241	0.147	−11.251
ATOM	2352	CA	LEU	211	−18.96	−0.911	−11.959
ATOM	2353	C	LEU	211	−19.959	−0.255	−12.883
ATOM	2354	O	LEU	211	−19.988	−0.582	−14.058
ATOM	2355	CB	LEU	211	−19.605	−1.888	−10.937
ATOM	2356	CG	LEU	211	−20.17	−3.212	−11.532
ATOM	2357	CD1	LEU	211	−20.435	−4.211	−10.37
ATOM	2358	CD2	LEU	211	−21.471	−2.992	−12.357
ATOM	2359	HB2	LEU	211	−18.809	−2.152	−10.221
ATOM	2360	HB1	LEU	211	−20.401	−1.373	−10.384
ATOM	2361	HG	LEU	211	−19.407	−3.664	−12.187
ATOM	2362	HD13	LEU	211	−20.821	−5.158	−10.766
ATOM	2363	HD12	LEU	211	−21.167	−3.804	−9.658
ATOM	2364	HD11	LEU	211	−19.506	−4.434	−9.822
ATOM	2365	HD23	LEU	211	−22.195	−2.383	−11.802
ATOM	2366	HD22	LEU	211	−21.947	−3.95	−12.61
ATOM	2367	HD21	LEU	211	−21.261	−2.479	−13.3
ATOM	2368	H	LEU	211	−18.35	0.241	−10.258
ATOM	2369	HA	LEU	211	−18.232	−1.48	−12.559
ATOM	2370	N	TYR	212	−20.778	0.695	−12.386
ATOM	2371	CA	TYR	212	−21.713	1.385	−13.271
ATOM	2372	C	TYR	212	−20.974	1.889	−14.488
ATOM	2373	O	TYR	212	−21.462	1.689	−15.589
ATOM	2374	CB	TYR	212	−22.413	2.582	−12.579
ATOM	2375	CG	TYR	212	−23.352	3.269	−13.58
ATOM	2376	CD1	TYR	212	−24.657	2.797	−13.758
ATOM	2377	CD2	TYR	212	−22.912	4.368	−14.327
ATOM	2378	CE1	TYR	212	−25.515	3.415	−14.673
ATOM	2379	CE2	TYR	212	−23.773	4.99	−15.235
ATOM	2380	CZ	TYR	212	−25.074	4.516	−15.418
ATOM	2381	OH	TYR	212	−25.908	5.151	−16.344
ATOM	2382	H	TYR	212	−20.742	0.953	−11.421
ATOM	2383	HB1	TYR	212	−21.662	3.297	−12.21
ATOM	2384	HB2	TYR	212	−22.992	2.227	−11.711
ATOM	2385	HD1	TYR	212	−25.01	1.944	−13.187
ATOM	2386	HD2	TYR	212	−21.899	4.741	−14.208
ATOM	2387	HE1	TYR	212	−26.523	3.031	−14.796
ATOM	2388	HE2	TYR	212	−23.431	5.847	−15.806
ATOM	2389	HH	TYR	212	−26.784	4.786	−16.397
ATOM	2390	HA	TYR	212	−22.482	0.662	−13.59
ATOM	2391	N	VAL	213	−19.793	2.526	−14.326
ATOM	2392	CA	VAL	213	−19.03	2.932	−15.507
ATOM	2393	C	VAL	213	−18.761	1.709	−16.356
ATOM	2394	O	VAL	213	−18.956	1.776	−17.558
ATOM	2395	CB	VAL	213	−17.714	3.688	−15.15
ATOM	2396	CG1	VAL	213	−16.76	3.796	−16.373
ATOM	2397	CG2	VAL	213	−18.037	5.11	−14.611
ATOM	2398	HB	VAL	213	−17.178	3.126	−14.369
ATOM	2399	HG23	VAL	213	−18.493	5.726	−15.402
ATOM	2400	HG22	VAL	213	−17.116	5.609	−14.271
ATOM	2401	HG21	VAL	213	−18.736	5.066	−13.764
ATOM	2402	HG13	VAL	213	−16.421	2.802	−16.705
ATOM	2403	HG12	VAL	213	−15.867	4.386	−16.113
ATOM	2404	HG11	VAL	213	−17.274	4.289	−17.209
ATOM	2405	H	VAL	213	−19.411	2.68	−13.411
ATOM	2406	HA	VAL	213	−19.657	3.613	−16.104
ATOM	2407	N	HIS	214	−18.326	0.566	−15.786
ATOM	2408	CA	HIS	214	−18.127	−0.616	−16.627
ATOM	2409	C	HIS	214	−19.405	−0.993	−17.355
ATOM	2410	O	HIS	214	−19.322	−1.411	−18.499
ATOM	2411	CB	HIS	214	−17.627	−1.85	−15.828
ATOM	2412	CG	HIS	214	−16.424	−1.599	−14.953
ATOM	2413	ND1	HIS	214	−15.592	−0.584	−15.05
ATOM	2414	CD2	HIS	214	−16.045	−2.404	−13.939
ATOM	2415	CE1	HIS	214	−14.678	−0.68	−14.136
ATOM	2416	NE2	HIS	214	−14.88	−1.714	−13.457
ATOM	2417	HB2	HIS	214	−18.432	−2.214	−15.175
ATOM	2418	HB1	HIS	214	−17.374	−2.656	−16.534
ATOM	2419	HD1	HIS	214	−15.65	0.18	−15.737
ATOM	2420	HD2	HIS	214	−16.497	−3.327	−13.579
ATOM	2421	HE1	HIS	214	−13.858	0.019	−13.971
ATOM	2422	H	HIS	214	−18.167	0.51	−14.796
ATOM	2423	HA	HIS	214	−17.368	−0.369	−17.389
ATOM	2424	N	MET	215	−20.592	−0.86	−16.717
ATOM	2425	CA	MET	215	−21.857	−1.208	−17.376
ATOM	2426	C	MET	215	−22.54	−0.022	−18.03
ATOM	2427	O	MET	215	−23.634	−0.222	−18.535
ATOM	2428	CB	MET	215	−22.826	−1.9	−16.365
ATOM	2429	CG	MET	215	−22.52	−3.409	−16.164
ATOM	2430	SD	MET	215	−20.764	−3.676	−15.759
ATOM	2431	CE	MET	215	−20.17	−4.633	−17.189
ATOM	2432	HB2	MET	215	−22.787	−1.374	−15.398
ATOM	2433	HB1	MET	215	−23.869	−1.848	−16.718
ATOM	2434	HG2	MET	215	−22.778	−3.977	−17.072
ATOM	2435	HG1	MET	215	−23.129	−3.797	−15.332
ATOM	2436	HE3	MET	215	−20.659	−5.619	−17.203
ATOM	2437	HE2	MET	215	−19.083	−4.768	−17.102
ATOM	2438	HE1	MET	215	−20.388	−4.098	−18.124
ATOM	2439	H	MET	215	−20.621	−0.495	−15.783
ATOM	2440	HA	MET	215	−21.694	−1.915	−18.204
ATOM	2441	LPD2	MET	215	−20.697	−4.029	−15.182
ATOM	2442	LPD1	MET	215	−20.433	−3.086	−15.703
ATOM	2443	N	PHE	216	−21.987	1.212	−18.082
ATOM	2444	CA	PHE	216	−22.74	2.33	−18.668
ATOM	2445	C	PHE	216	−22.832	2.279	−20.182
ATOM	2446	O	PHE	216	−22.507	3.263	−20.829
ATOM	2447	CB	PHE	216	−22.2	3.701	−18.166
ATOM	2448	CG	PHE	216	−20.81	4.144	−18.662
ATOM	2449	CD1	PHE	216	−20.349	5.398	−18.243
ATOM	2450	CD2	PHE	216	−19.992	3.376	−19.503
ATOM	2451	CE1	PHE	216	−19.125	5.902	−18.693
ATOM	2452	CE2	PHE	216	−18.771	3.878	−19.961
ATOM	2453	CZ	PHE	216	−18.34	5.147	−19.567
ATOM	2454	HB2	PHE	216	−22.911	4.488	−18.467
ATOM	2455	HB1	PHE	216	−22.168	3.678	−17.067
ATOM	2456	HD1	PHE	216	−20.946	5.993	−17.56
ATOM	2457	HD2	PHE	216	−20.28	2.379	−19.814
ATOM	2458	HE1	PHE	216	−18.785	6.879	−18.364
ATOM	2459	HE2	PHE	216	−18.154	3.28	−20.624
ATOM	2460	HZ	PHE	216	−17.398	5.543	−19.935
ATOM	2461	H	PHE	216	−21.083	1.387	−17.687
ATOM	2462	HA	PHE	216	−23.78	2.27	−18.303
ATOM	2463	N	LEU	217	−23.271	1.156	−20.795
ATOM	2464	CA	LEU	217	−23.214	1.044	−22.253
ATOM	2465	C	LEU	217	−24.105	−0.079	−22.729
ATOM	2466	O	LEU	217	−25.013	0.131	−23.517
ATOM	2467	CB	LEU	217	−21.737	0.766	−22.648
ATOM	2468	CG	LEU	217	−21.51	0.448	−24.158
ATOM	2469	CD1	LEU	217	−21.976	1.611	−25.078
ATOM	2470	CD2	LEU	217	−20.005	0.147	−24.408
ATOM	2471	HB2	LEU	217	−21.121	1.636	−22.368
ATOM	2472	HB1	LEU	217	−21.39	−0.093	−22.051
ATOM	2473	HG	LEU	217	−22.079	−0.459	−24.429
ATOM	2474	HD13	LEU	217	−23.066	1.747	−25.027
ATOM	2475	HD12	LEU	217	−21.718	1.395	−26.126
ATOM	2476	HD11	LEU	217	−21.486	2.552	−24.784
ATOM	2477	HD23	LEU	217	−19.392	1.031	−24.172
ATOM	2478	HD22	LEU	217	−19.834	−0.124	−25.462
ATOM	2479	HD21	LEU	217	−19.668	−0.692	−23.78
ATOM	2480	H	LEU	217	−23.589	0.369	−20.265
ATOM	2481	HA	LEU	217	−23.567	1.984	−22.708
ATOM	2482	H9	LEU	217	−23.943	−1.096	−22.374
ATOM	2483	N	ALA	239	−36.516	−5.492	−20.37
ATOM	2484	CA	ALA	239	−36.554	−5.98	−18.994
ATOM	2485	C	ALA	239	−35.169	−5.921	−18.384
ATOM	2486	O	ALA	239	−35.008	−5.378	−17.302
ATOM	2487	CB	ALA	239	−37.089	−7.434	−18.919
ATOM	2488	H	ALA	239	−37.091	−5.919	−21.07
ATOM	2489	HB3	ALA	239	−36.463	−8.11	−19.521
ATOM	2490	HB2	ALA	239	−38.121	−7.479	−19.303
ATOM	2491	HB1	ALA	239	−37.088	−7.786	−17.876
ATOM	2492	HA	ALA	239	−37.237	−5.335	−18.418
ATOM	2493	H10	ALA	239	−35.977	−4.677	−20.59
ATOM	2494	N	ASN	240	−34.147	−6.478	−19.072
ATOM	2495	CA	ASN	240	−32.797	−6.457	−18.509
ATOM	2496	C	ASN	240	−32.36	−5.027	−18.285
ATOM	2497	O	ASN	240	−31.9	−4.695	−17.202
ATOM	2498	CB	ASN	240	−31.781	−7.168	−19.446
ATOM	2499	CG	ASN	240	−30.379	−7.207	−18.889
ATOM	2500	OD1	ASN	240	−30.168	−6.839	−17.745
ATOM	2501	ND2	ASN	240	−29.39	−7.665	−19.684
ATOM	2502	HB2	ASN	240	−32.106	−8.208	−19.603
ATOM	2503	HB1	ASN	240	−31.759	−6.661	−20.422
ATOM	2504	HD21	ASN	240	−29.565	−7.969	−20.62
ATOM	2505	HD22	ASN	240	−28.458	−7.721	−19.323
ATOM	2506	H	ASN	240	−34.302	−6.904	−19.965
ATOM	2507	HA	ASN	240	−32.825	−6.992	−17.547
ATOM	2508	N	MET	241	−32.512	−4.161	−19.313
ATOM	2509	CA	MET	241	−32.111	−2.766	−19.156
ATOM	2510	C	MET	241	−33.046	−2.107	−18.169
ATOM	2511	O	MET	241	−32.577	−1.285	−17.4
ATOM	2512	CB	MET	241	−32.104	−1.969	−20.491
ATOM	2513	CG	MET	241	−30.866	−2.292	−21.372
ATOM	2514	SD	MET	241	−30.788	−4.061	−21.806
ATOM	2515	CE	MET	241	−29.205	−4.112	−22.702
ATOM	2516	HB2	MET	241	−33.035	−2.16	−21.048
ATOM	2517	HB1	MET	241	−32.067	−0.89	−20.26
ATOM	2518	HG2	MET	241	−29.941	−2.023	−20.837
ATOM	2519	HG1	MET	241	−30.909	−1.71	−22.306
ATOM	2520	HE3	MET	241	−29.245	−3.437	−23.57
ATOM	2521	HE2	MET	241	−29.022	−5.139	−23.048
ATOM	2522	HE1	MET	241	−28.387	−3.804	−22.034
ATOM	2523	H	MET	241	−32.947	−4.449	−20.167
ATOM	2524	HA	MET	241	−31.094	−2.73	−18.731
ATOM	2525	LPD2	MET	241	−31.307	−4.245	−22.203
ATOM	2526	LPD1	MET	241	−30.776	−4.455	−21.253
ATOM	2527	N	LYS	242	−34.357	−2.439	−18.135
ATOM	2528	CA	LYS	242	−35.204	−1.854	−17.096
ATOM	2529	C	LYS	242	−34.586	−2.173	−15.753
ATOM	2530	O	LYS	242	−34.551	−1.302	−14.898
ATOM	2531	CB	LYS	242	−36.681	−2.333	−17.165
ATOM	2532	CG	LYS	242	−37.629	−1.546	−16.203
ATOM	2533	CD	LYS	242	−38.269	−2.414	−15.08
ATOM	2534	CE	LYS	242	−37.232	−2.959	−14.06
ATOM	2535	NZ	LYS	242	−37.883	−3.605	−12.895
ATOM	2536	HB2	LYS	242	−37.016	−2.185	−18.206
ATOM	2537	HB1	LYS	242	−36.722	−3.412	−16.965
ATOM	2538	HG2	LYS	242	−38.461	−1.122	−16.792
ATOM	2539	HG1	LYS	242	−37.107	−0.694	−15.738
ATOM	2540	HD2	LYS	242	−38.824	−3.254	−15.531
ATOM	2541	HD1	LYS	242	−38.995	−1.786	−14.538
ATOM	2542	HE2	LYS	242	−36.614	−2.123	−13.701
ATOM	2543	HE1	LYS	242	−36.571	−3.689	−14.556
ATOM	2544	HZ3	LYS	242	−38.446	−2.905	−12.295
ATOM	2545	HZ2	LYS	242	−37.151	−4.035	−12.227
ATOM	2546	HZ1	LYS	242	−38.556	−4.399	−13.188
ATOM	2547	H	LYS	242	−34.749	−3.099	−18.776
ATOM	2548	HA	LYS	242	−35.196	−0.764	−17.254
ATOM	2549	N	GLY	243	−34.07	−3.409	−15.556
ATOM	2550	CA	GLY	243	−33.344	−3.717	−14.325
ATOM	2551	C	GLY	243	−32.26	−2.695	−14.07
ATOM	2552	O	GLY	243	−32.153	−2.186	−12.965
ATOM	2553	H	GLY	243	−34.147	−4.125	−16.258
ATOM	2554	HA1	GLY	243	−34.048	−3.76	−13.481
ATOM	2555	HA2	GLY	243	−32.848	−4.698	−14.398
ATOM	2556	N	ALA	244	−31.433	−2.383	−15.092
ATOM	2557	CA	ALA	244	−30.395	−1.371	−14.899
ATOM	2558	C	ALA	244	−31.005	−0.012	−14.645
ATOM	2559	O	ALA	244	−30.48	0.726	−13.827
ATOM	2560	CB	ALA	244	−29.468	−1.248	−16.138
ATOM	2561	HB3	ALA	244	−30.036	−0.899	−17.014
ATOM	2562	HB2	ALA	244	−29.014	−2.219	−16.382
ATOM	2563	HB1	ALA	244	−28.662	−0.525	−15.937
ATOM	2564	H	ALA	244	−31.539	−2.814	−15.991
ATOM	2565	HA	ALA	244	−29.781	−1.655	−14.027
ATOM	2566	N	ILE	245	−32.103	0.365	−15.334
ATOM	2567	CA	ILE	245	−32.641	1.711	−15.151
ATOM	2568	C	ILE	245	−33.213	1.826	−13.758
ATOM	2569	O	ILE	245	−32.877	2.775	−13.069
ATOM	2570	CB	ILE	245	−33.691	2.103	−16.234
ATOM	2571	CG1	ILE	245	−33.012	2.169	−17.639
ATOM	2572	CG2	ILE	245	−34.36	3.458	−15.863
ATOM	2573	CD1	ILE	245	−34.018	2.183	−18.823
ATOM	2574	HB	ILE	245	−34.474	1.329	−16.241
ATOM	2575	HG23	ILE	245	−34.951	3.366	−14.94
ATOM	2576	HG22	ILE	245	−35.041	3.789	−16.654
ATOM	2577	HG21	ILE	245	−33.597	4.238	−15.716
ATOM	2578	HG12	ILE	245	−32.365	1.29	−17.785
ATOM	2579	HG11	ILE	245	−32.369	3.062	−17.696
ATOM	2580	HD13	ILE	245	−34.691	1.314	−18.767
ATOM	2581	HD12	ILE	245	−33.468	2.131	−19.777
ATOM	2582	HD11	ILE	245	−34.624	3.1	−18.839
ATOM	2583	H	ILE	245	−32.555	−0.269	−15.964
ATOM	2584	HA	ILE	245	−31.81	2.43	−15.24
ATOM	2585	N	THR	246	−34.077	0.894	−13.297
ATOM	2586	CA	THR	246	−34.577	1.028	−11.929
ATOM	2587	C	THR	246	−33.398	1.055	−10.984
ATOM	2588	O	THR	246	−33.463	1.792	−10.015
ATOM	2589	CB	THR	246	−35.641	−0.017	−11.495
ATOM	2590	OG1	THR	246	−36.251	0.439	−10.273
ATOM	2591	CG2	THR	246	−35.035	−1.425	−11.276
ATOM	2592	HB	THR	246	−36.413	−0.054	−12.284
ATOM	2593	HG22	THR	246	−35.832	−2.141	−11.026
ATOM	2594	HG21	THR	246	−34.309	−1.413	−10.45
ATOM	2595	HG23	THR	246	−34.532	−1.765	−12.187
ATOM	2596	HG1	THR	246	−36.952	−0.128	−9.964
ATOM	2597	H	THR	246	−34.352	0.112	−13.859
ATOM	2598	HA	THR	246	−35.081	2.007	−11.866
ATOM	2599	N	LEU	247	−32.299	0.304	−11.237
ATOM	2600	CA	LEU	247	−31.116	0.465	−10.388
ATOM	2601	C	LEU	247	−30.736	1.931	−10.467
ATOM	2602	O	LEU	247	−30.704	2.591	−9.441
ATOM	2603	CB	LEU	247	−29.944	−0.481	−10.798
ATOM	2604	CG	LEU	247	−28.825	−0.675	−9.728
ATOM	2605	CD1	LEU	247	−27.729	−1.636	−10.268
ATOM	2606	CD2	LEU	247	−28.145	0.655	−9.306
ATOM	2607	HB2	LEU	247	−30.376	−1.476	−10.994
ATOM	2608	HB1	LEU	247	−29.479	−0.132	−11.729
ATOM	2609	HG	LEU	247	−29.275	−1.135	−8.832
ATOM	2610	HD13	LEU	247	−28.163	−2.581	−10.619
ATOM	2611	HD12	LEU	247	−27.01	−1.864	−9.467
ATOM	2612	HD11	LEU	247	−27.187	−1.174	−11.107
ATOM	2613	HD23	LEU	247	−27.811	1.221	−10.189
ATOM	2614	HD22	LEU	247	−27.276	0.465	−8.657
ATOM	2615	HD21	LEU	247	−28.847	1.266	−8.734
ATOM	2616	H	LEU	247	−32.255	−0.317	−12.024
ATOM	2617	HA	LEU	247	−31.401	0.211	−9.354
ATOM	2618	N	THR	248	−30.469	2.47	−11.68
ATOM	2619	CA	THR	248	−30.054	3.868	−11.798
ATOM	2620	C	THR	248	−30.951	4.789	−10.999
ATOM	2621	O	THR	248	−30.441	5.675	−10.331
ATOM	2622	CB	THR	248	−30.032	4.332	−13.281
ATOM	2623	OG1	THR	248	−29.277	3.361	−14.029
ATOM	2624	CG2	THR	248	−29.389	5.737	−13.437
ATOM	2625	HB	THR	248	−31.067	4.37	−13.661
ATOM	2626	HG22	THR	248	−29.384	6.034	−14.497
ATOM	2627	HG21	THR	248	−28.35	5.721	−13.074
ATOM	2628	HG23	THR	248	−29.954	6.493	−12.87
ATOM	2629	HG1	THR	248	−29.252	3.543	−14.962
ATOM	2630	H	THR	248	−30.527	1.924	−12.519
ATOM	2631	HA	THR	248	−29.02	3.931	−11.426
ATOM	2632	N	ILE	249	−32.29	4.608	−11.048
ATOM	2633	CA	ILE	249	−33.168	5.504	−10.292
ATOM	2634	C	ILE	249	−33.013	5.219	−8.813
ATOM	2635	O	ILE	249	−32.851	6.149	−8.039
ATOM	2636	CB	ILE	249	−34.677	5.393	−10.673
ATOM	2637	CG1	ILE	249	−34.948	5.438	−12.21
ATOM	2638	CG2	ILE	249	−35.506	6.489	−9.94
ATOM	2639	CD1	ILE	249	−34.201	6.563	−12.973
ATOM	2640	H	ILE	249	−32.681	3.844	−11.565
ATOM	2641	HB	ILE	249	−35.046	4.415	−10.315
ATOM	2642	HG12	ILE	249	−36.031	5.561	−12.366
ATOM	2643	HG11	ILE	249	−34.675	4.48	−12.673
ATOM	2644	HG23	ILE	249	−35.356	6.436	−8.854
ATOM	2645	HG22	ILE	249	−36.582	6.36	−10.133
ATOM	2646	HG21	ILE	249	−35.211	7.496	−10.268
ATOM	2647	HD13	ILE	249	−34.437	7.553	−12.558
ATOM	2648	HD12	ILE	249	−34.503	6.554	−14.033
ATOM	2649	HD11	ILE	249	−33.112	6.409	−12.934
ATOM	2650	HA	ILE	249	−32.851	6.544	−10.475
ATOM	2651	N	LEU	250	−33.07	3.934	−8.399
ATOM	2652	CA	LEU	250	−33	3.613	−6.976
ATOM	2653	C	LEU	250	−31.715	4.175	−6.4
ATOM	2654	O	LEU	250	−31.768	4.891	−5.412
ATOM	2655	CB	LEU	250	−33.067	2.083	−6.709
ATOM	2656	CG	LEU	250	−34.445	1.416	−7.019
ATOM	2657	CD1	LEU	250	−34.275	−0.117	−7.226
ATOM	2658	CD2	LEU	250	−35.478	1.666	−5.885
ATOM	2659	HB2	LEU	250	−32.285	1.616	−7.326
ATOM	2660	HB1	LEU	250	−32.825	1.903	−5.65
ATOM	2661	HG	LEU	250	−34.86	1.83	−7.951
ATOM	2662	HD13	LEU	250	−33.596	−0.325	−8.067
ATOM	2663	HD12	LEU	250	−35.244	−0.589	−7.45
ATOM	2664	HD11	LEU	250	−33.859	−0.581	−6.318
ATOM	2665	HD23	LEU	250	−35.111	1.242	−4.94
ATOM	2666	HD22	LEU	250	−36.437	1.183	−6.128
ATOM	2667	HD21	LEU	250	−35.661	2.739	−5.735
ATOM	2668	H	LEU	250	−33.155	3.189	−9.061
ATOM	2669	HA	LEU	250	−33.851	4.089	−6.469
ATOM	2670	N	ILE	251	−30.538	3.876	−6.997
ATOM	2671	CA	ILE	251	−29.301	4.454	−6.467
ATOM	2672	C	ILE	251	−29.315	5.953	−6.671
ATOM	2673	O	ILE	251	−28.808	6.674	−5.825
ATOM	2674	CB	ILE	251	−27.997	3.794	−7.009
ATOM	2675	CG1	ILE	251	−26.769	4.104	−6.096
ATOM	2676	CG2	ILE	251	−27.722	4.202	−8.482
ATOM	2677	CD1	ILE	251	−25.496	3.322	−6.521
ATOM	2678	HB	ILE	251	−28.159	2.705	−6.963
ATOM	2679	HG23	ILE	251	−28.626	4.069	−9.085
ATOM	2680	HG22	ILE	251	−26.936	3.579	−8.932
ATOM	2681	HG21	ILE	251	−27.417	5.257	−8.544
ATOM	2682	HG12	ILE	251	−26.999	3.813	−5.058
ATOM	2683	HG11	ILE	251	−26.554	5.185	−6.101
ATOM	2684	HD13	ILE	251	−25.731	2.255	−6.651
ATOM	2685	HD12	ILE	251	−24.718	3.409	−5.749
ATOM	2686	HD11	ILE	251	−25.078	3.711	−7.461
ATOM	2687	H	ILE	251	−30.509	3.297	−7.815
ATOM	2688	HA	ILE	251	−29.328	4.261	−5.389
ATOM	2689	N	GLY	252	−29.903	6.453	−7.781
ATOM	2690	CA	GLY	252	−29.984	7.896	−7.975
ATOM	2691	C	GLY	252	−30.655	8.56	−6.798
ATOM	2692	O	GLY	252	−30.162	9.58	−6.343
ATOM	2693	H	GLY	252	−30.302	5.862	−8.487
ATOM	2694	HA1	GLY	252	−28.967	8.298	−8.106
ATOM	2695	HA2	GLY	252	−30.57	8.146	−8.874
ATOM	2696	N	VAL	253	−31.785	8.018	−6.287
ATOM	2697	CA	VAL	253	−32.399	8.624	−5.105
ATOM	2698	C	VAL	253	−31.65	8.229	−3.85
ATOM	2699	O	VAL	253	−31.634	9.019	−2.919
ATOM	2700	CB	VAL	253	−33.923	8.363	−4.924
ATOM	2701	CG1	VAL	253	−34.715	8.833	−6.176
ATOM	2702	CG2	VAL	253	−34.251	6.884	−4.59
ATOM	2703	HB	VAL	253	−34.262	8.968	−4.063
ATOM	2704	HG23	VAL	253	−34.015	6.236	−5.441
ATOM	2705	HG22	VAL	253	−35.323	6.788	−4.374
ATOM	2706	HG21	VAL	253	−33.696	6.532	−3.707
ATOM	2707	HG13	VAL	253	−34.494	9.888	−6.4
ATOM	2708	HG12	VAL	253	−35.798	8.743	−6
ATOM	2709	HG11	VAL	253	−34.453	8.227	−7.056
ATOM	2710	H	VAL	253	−32.176	7.182	−6.681
ATOM	2711	HA	VAL	253	−32.306	9.716	−5.212
ATOM	2712	N	PHE	254	−31.028	7.028	−3.779
ATOM	2713	CA	PHE	254	−30.301	6.66	−2.564
ATOM	2714	C	PHE	254	−29.414	7.8	−2.118
ATOM	2715	O	PHE	254	−29.435	8.16	−0.952
ATOM	2716	CB	PHE	254	−29.411	5.4	−2.748
ATOM	2717	CG	PHE	254	−28.611	5.105	−1.471
ATOM	2718	CD1	PHE	254	−29.059	4.163	−0.538
ATOM	2719	CD2	PHE	254	−27.415	5.792	−1.232
ATOM	2720	CE1	PHE	254	−28.389	4.007	0.68
ATOM	2721	CE2	PHE	254	−26.753	5.652	−0.011
ATOM	2722	CZ	PHE	254	−27.265	4.789	0.961
ATOM	2723	H	PHE	254	−31.08	6.365	−4.528
ATOM	2724	HB2	PHE	254	−28.689	5.574	−3.557
ATOM	2725	HB1	PHE	254	−30.037	4.535	−3.019
ATOM	2726	HD1	PHE	254	−29.934	3.556	−0.748
ATOM	2727	HD2	PHE	254	−26.99	6.437	−1.993
ATOM	2728	HE1	PHE	254	−28.747	3.287	1.409
ATOM	2729	HE2	PHE	254	−25.844	6.211	0.18
ATOM	2730	HZ	PHE	254	−26.786	4.735	1.929
ATOM	2731	HA	PHE	254	−31.044	6.436	−1.782
ATOM	2732	N	VAL	255	−28.606	8.39	−3.028
ATOM	2733	CA	VAL	255	−27.677	9.422	−2.572
ATOM	2734	C	VAL	255	−28.431	10.579	−1.954
ATOM	2735	O	VAL	255	−28.038	10.998	−0.877
ATOM	2736	CB	VAL	255	−26.617	9.897	−3.614
ATOM	2737	CG1	VAL	255	−25.686	8.723	−4.032
ATOM	2738	CG2	VAL	255	−27.234	10.573	−4.869
ATOM	2739	HB	VAL	255	−25.986	10.656	−3.118
ATOM	2740	HG23	VAL	255	−27.849	9.86	−5.433
ATOM	2741	HG22	VAL	255	−26.435	10.932	−5.535
ATOM	2742	HG21	VAL	255	−27.851	11.439	−4.59
ATOM	2743	HG13	VAL	255	−25.184	8.302	−3.148
ATOM	2744	HG12	VAL	255	−24.908	9.077	−4.726
ATOM	2745	HG11	VAL	255	−26.253	7.922	−4.529
ATOM	2746	H	VAL	255	−28.627	8.115	−3.991
ATOM	2747	HA	VAL	255	−27.093	8.972	−1.75
ATOM	2748	N	VAL	256	−29.513	11.126	−2.553
ATOM	2749	CA	VAL	256	−30.177	12.257	−1.898
ATOM	2750	C	VAL	256	−30.844	11.779	−0.628
ATOM	2751	O	VAL	256	−30.892	12.531	0.331
ATOM	2752	CB	VAL	256	−31.186	13.066	−2.77
ATOM	2753	CG1	VAL	256	−30.545	13.501	−4.117
ATOM	2754	CG2	VAL	256	−32.525	12.318	−3.011
ATOM	2755	HB	VAL	256	−31.442	13.984	−2.21
ATOM	2756	HG23	VAL	256	−32.341	11.375	−3.536
ATOM	2757	HG22	VAL	256	−33.2	12.931	−3.629
ATOM	2758	HG21	VAL	256	−33.041	12.098	−2.064
ATOM	2759	HG13	VAL	256	−29.59	14.019	−3.938
ATOM	2760	HG12	VAL	256	−31.216	14.192	−4.652
ATOM	2761	HG11	VAL	256	−30.358	12.636	−4.77
ATOM	2762	H	VAL	256	−29.893	10.732	−3.392
ATOM	2763	HA	VAL	256	−29.39	12.974	−1.606
ATOM	2764	N	CYS	257	−31.374	10.536	−0.595
ATOM	2765	CA	CYS	257	−32.021	10.046	0.62
ATOM	2766	C	CYS	257	−31.038	9.952	1.77
ATOM	2767	O	CYS	257	−31.35	10.418	2.855
ATOM	2768	CB	CYS	257	−32.668	8.658	0.358
ATOM	2769	SG	CYS	257	−33.268	7.875	1.887
ATOM	2770	H	CYS	257	−31.332	9.936	−1.398
ATOM	2771	HB2	CYS	257	−31.926	7.969	−0.065
ATOM	2772	HB1	CYS	257	−33.499	8.751	−0.36
ATOM	2773	HA	CYS	257	−32.826	10.745	0.894
ATOM	2774	HG	CYS	257	−33.883	8.611	2.194
ATOM	2775	LPG2	CYS	257	−32.767	7.758	2.33
ATOM	2776	LPG1	CYS	257	−33.602	7.296	1.765
ATOM	2777	N	TRP	258	−29.854	9.334	1.557
ATOM	2778	CA	TRP	258	−28.916	9.088	2.66
ATOM	2779	C	TRP	258	−27.758	10.065	2.717
ATOM	2780	O	TRP	258	−27.364	10.446	3.809
ATOM	2781	CB	TRP	258	−28.33	7.665	2.493
ATOM	2782	CG	TRP	258	−29.417	6.629	2.607
ATOM	2783	CD1	TRP	258	−30.183	6.118	1.63
ATOM	2784	CD2	TRP	258	−29.844	5.949	3.881
ATOM	2785	NE1	TRP	258	−30.996	5.22	2.124
ATOM	2786	CE2	TRP	258	−30.82	5.072	3.45
ATOM	2787	CE3	TRP	258	−29.461	6.043	5.216
ATOM	2788	CZ2	TRP	258	−31.459	4.198	4.328
ATOM	2789	CZ3	TRP	258	−30.08	5.158	6.107
ATOM	2790	CH2	TRP	258	−31.06	4.25	5.67
ATOM	2791	H	TRP	258	−29.623	9.009	0.636
ATOM	2792	HB2	TRP	258	−27.572	7.462	3.266
ATOM	2793	HB1	TRP	258	−27.84	7.59	1.511
ATOM	2794	HD1	TRP	258	−30.129	6.402	0.585
ATOM	2795	HE1	TRP	258	−31.678	4.684	1.566
ATOM	2796	HE3	TRP	258	−28.718	6.763	5.539
ATOM	2797	HZ2	TRP	258	−32.225	3.51	3.986
ATOM	2798	HZ3	TRP	258	−29.789	5.176	7.151
ATOM	2799	HH2	TRP	258	−31.518	3.571	6.38
ATOM	2800	HA	TRP	258	−29.431	9.116	3.635
ATOM	2801	N	ALA	259	−27.177	10.475	1.566
ATOM	2802	CA	ALA	259	−25.984	11.316	1.608
ATOM	2803	C	ALA	259	−26.092	12.521	2.519
ATOM	2804	O	ALA	259	−25.139	12.698	3.259
ATOM	2805	CB	ALA	259	−25.488	11.797	0.218
ATOM	2806	HB3	ALA	259	−26.191	12.512	−0.229
ATOM	2807	HB2	ALA	259	−25.366	10.94	−0.463
ATOM	2808	HB1	ALA	259	−24.512	12.299	0.32
ATOM	2809	H	ALA	259	−27.516	10.183	0.67
ATOM	2810	HA	ALA	259	−25.186	10.663	2.004
ATOM	2811	N	PRO	260	−27.131	13.394	2.56
ATOM	2812	CA	PRO	260	−27.038	14.558	3.433
ATOM	2813	C	PRO	260	−26.922	14.168	4.891
ATOM	2814	O	PRO	260	−26.236	14.864	5.622
ATOM	2815	CB	PRO	260	−28.348	15.302	3.074
ATOM	2816	CG	PRO	260	−29.284	14.2	2.527
ATOM	2817	CD	PRO	260	−28.334	13.258	1.748
ATOM	2818	HB2	PRO	260	−28.152	16.014	2.255
ATOM	2819	HB1	PRO	260	−28.779	15.855	3.922
ATOM	2820	HG1	PRO	260	−29.738	13.659	3.374
ATOM	2821	HG2	PRO	260	−30.093	14.605	1.897
ATOM	2822	HD1	PRO	260	−28.769	12.253	1.701
ATOM	2823	HD2	PRO	260	−28.154	13.641	0.732
ATOM	2824	HA	PRO	260	−26.166	15.174	3.156
ATOM	2825	N	PHE	261	−27.551	13.064	5.349
ATOM	2826	CA	PHE	261	−27.38	12.651	6.745
ATOM	2827	C	PHE	261	−25.974	12.133	6.948
ATOM	2828	O	PHE	261	−25.336	12.497	7.924
ATOM	2829	CB	PHE	261	−28.405	11.545	7.1
ATOM	2830	CG	PHE	261	−28.353	11.116	8.575
ATOM	2831	CD1	PHE	261	−29.014	11.859	9.56
ATOM	2832	CD2	PHE	261	−27.673	9.954	8.953
ATOM	2833	CE1	PHE	261	−29.118	11.364	10.863
ATOM	2834	CE2	PHE	261	−27.888	9.392	10.214
ATOM	2835	CZ	PHE	261	−28.604	10.104	11.18
ATOM	2836	HB2	PHE	261	−29.427	11.897	6.89
ATOM	2837	HB1	PHE	261	−28.218	10.682	6.445
ATOM	2838	HD1	PHE	261	−29.455	12.819	9.322
ATOM	2839	HD2	PHE	261	−26.987	9.477	8.265
ATOM	2840	HE1	PHE	261	−29.602	11.957	11.63
ATOM	2841	HE2	PHE	261	−27.503	8.403	10.443
ATOM	2842	H15	PHE	261	−28.757	9.681	12.168
ATOM	2843	H	PHE	261	−28.078	12.481	4.728
ATOM	2844	HA	PHE	261	−27.555	13.507	7.417
ATOM	2845	N	PHE	262	−25.461	11.283	6.03
ATOM	2846	CA	PHE	262	−24.092	10.784	6.184
ATOM	2847	C	PHE	262	−23.102	11.918	5.982
ATOM	2848	O	PHE	262	−22.035	11.881	6.576
ATOM	2849	CB	PHE	262	−23.791	9.561	5.267
ATOM	2850	CG	PHE	262	−24.294	8.266	5.934
ATOM	2851	CD1	PHE	262	−25.646	8.106	6.259
ATOM	2852	CD2	PHE	262	−23.406	7.231	6.253
ATOM	2853	CE1	PHE	262	−26.05	7.075	7.112
ATOM	2854	CE2	PHE	262	−23.813	6.167	7.063
ATOM	2855	CZ	PHE	262	−25.127	6.115	7.535
ATOM	2856	HB2	PHE	262	−24.245	9.678	4.271
ATOM	2857	HB1	PHE	262	−22.7	9.494	5.126
ATOM	2858	HD1	PHE	262	−26.392	8.782	5.859
ATOM	2859	HD2	PHE	262	−22.392	7.243	5.877
ATOM	2860	HE1	PHE	262	−27.079	7.018	7.45
ATOM	2861	HE2	PHE	262	−23.108	5.385	7.329
ATOM	2862	HZ	PHE	262	−25.431	5.331	8.221
ATOM	2863	H	PHE	262	−25.983	11.04	5.207
ATOM	2864	HA	PHE	262	−23.963	10.441	7.223
ATOM	2865	N	LEU	263	−23.424	12.951	5.172
ATOM	2866	CA	LEU	263	−22.537	14.107	5.053
ATOM	2867	C	LEU	263	−22.597	14.814	6.389
ATOM	2868	O	LEU	263	−21.57	15.05	7.004
ATOM	2869	CB	LEU	263	−22.967	15.041	3.882
ATOM	2870	CG	LEU	263	−21.911	16.095	3.428
ATOM	2871	CD1	LEU	263	−22.489	16.92	2.242
ATOM	2872	CD2	LEU	263	−21.473	17.057	4.566
ATOM	2873	HB2	LEU	263	−23.173	14.399	3.011
ATOM	2874	HB1	LEU	263	−23.902	15.556	4.148
ATOM	2875	HG	LEU	263	−21.013	15.565	3.061
ATOM	2876	HD13	LEU	263	−22.791	16.258	1.415
ATOM	2877	HD12	LEU	263	−21.738	17.625	1.854
ATOM	2878	HD11	LEU	263	−23.37	17.494	2.57
ATOM	2879	HD23	LEU	263	−22.35	17.451	5.103
ATOM	2880	HD22	LEU	263	−20.904	17.907	4.159
ATOM	2881	HD21	LEU	263	−20.812	16.545	5.278
ATOM	2882	H	LEU	263	−24.299	12.971	4.689
ATOM	2883	HA	LEU	263	−21.523	13.744	4.833
ATOM	2884	N	HIS	264	−23.81	15.149	6.883
ATOM	2885	CA	HIS	264	−23.9	15.805	8.185
ATOM	2886	C	HIS	264	−23.127	15.002	9.201
ATOM	2887	O	HIS	264	−22.53	15.6	10.08
ATOM	2888	CB	HIS	264	−25.364	15.962	8.669
ATOM	2889	CG	HIS	264	−25.45	16.816	9.909
ATOM	2890	ND1	HIS	264	−24.947	16.49	11.078
ATOM	2891	CD2	HIS	264	−26.046	18.023	9.986
ATOM	2892	CE1	HIS	264	−25.169	17.44	11.929
ATOM	2893	NE2	HIS	264	−25.806	18.357	11.362
ATOM	2894	HB2	HIS	264	−25.923	16.464	7.868
ATOM	2895	HB1	HIS	264	−25.823	14.979	8.856
ATOM	2896	HD1	HIS	264	−24.447	15.615	11.29
ATOM	2897	HD2	HIS	264	−26.566	18.596	9.22
ATOM	2898	HE1	HIS	264	−24.87	17.468	12.976
ATOM	2899	H	HIS	264	−24.655	14.939	6.387
ATOM	2900	HA	HIS	264	−23.455	16.809	8.092
ATOM	2901	N	LEU	265	−23.121	13.654	9.117
ATOM	2902	CA	LEU	265	−22.331	12.879	10.069
ATOM	2903	C	LEU	265	−20.859	13.157	9.857
ATOM	2904	O	LEU	265	−20.216	13.6	10.797
ATOM	2905	CB	LEU	265	−22.654	11.363	9.966
ATOM	2906	CG	LEU	265	−21.987	10.444	11.033
ATOM	2907	CD1	LEU	265	−20.453	10.303	10.855
ATOM	2908	CD2	LEU	265	−22.334	10.838	12.495
ATOM	2909	HB2	LEU	265	−23.748	11.259	10.049
ATOM	2910	HB1	LEU	265	−22.364	10.997	8.972
ATOM	2911	HG	LEU	265	−22.397	9.435	10.856
ATOM	2912	HD13	LEU	265	−20.181	10.115	9.805
ATOM	2913	HD12	LEU	265	−20.131	9.446	11.456
ATOM	2914	HD11	LEU	265	−19.902	11.179	11.218
ATOM	2915	HD23	LEU	265	−21.82	11.765	12.79
ATOM	2916	HD22	LEU	265	−22.015	10.042	13.186
ATOM	2917	HD21	LEU	265	−23.419	10.984	12.614
ATOM	2918	H	LEU	265	−23.647	13.173	8.41
ATOM	2919	HA	LEU	265	−22.628	13.21	11.076
ATOM	2920	N	ILE	266	−20.283	12.905	8.654
ATOM	2921	CA	ILE	266	−18.833	13.078	8.507
ATOM	2922	C	ILE	266	−18.453	14.499	8.869
ATOM	2923	O	ILE	266	−17.375	14.72	9.397
ATOM	2924	CB	ILE	266	−18.25	12.663	7.117
ATOM	2925	CG1	ILE	266	−16.722	12.34	7.172
ATOM	2926	CG2	ILE	266	−18.486	13.775	6.057
ATOM	2927	CD1	ILE	266	−16.379	10.965	7.811
ATOM	2928	HB	ILE	266	−18.774	11.752	6.781
ATOM	2929	HG23	ILE	266	−19.54	14.062	6.041
ATOM	2930	HG22	ILE	266	−18.218	13.419	5.05
ATOM	2931	HG21	ILE	266	−17.884	14.67	6.279
ATOM	2932	HG12	ILE	266	−16.191	13.141	7.711
ATOM	2933	HG11	ILE	266	−16.32	12.309	6.145
ATOM	2934	HD13	ILE	266	−16.711	10.886	8.855
ATOM	2935	HD12	ILE	266	−15.288	10.811	7.793
ATOM	2936	HD11	ILE	266	−16.845	10.157	7.228
ATOM	2937	H	ILE	266	−20.828	12.593	7.87
ATOM	2938	HA	ILE	266	−18.397	12.409	9.26
ATOM	2939	N	PHE	267	−19.33	15.494	8.609
ATOM	2940	CA	PHE	267	−19.047	16.842	9.095
ATOM	2941	C	PHE	267	−19.101	16.84	10.607
ATOM	2942	O	PHE	267	−18.134	17.242	11.233
ATOM	2943	CB	PHE	267	−20.055	17.882	8.535
ATOM	2944	CG	PHE	267	−19.938	19.209	9.299
ATOM	2945	CD1	PHE	267	−18.795	20.003	9.15
ATOM	2946	CD2	PHE	267	−20.964	19.635	10.151
ATOM	2947	CE1	PHE	267	−18.685	21.218	9.831
ATOM	2948	CE2	PHE	267	−20.866	20.86	10.816
ATOM	2949	CZ	PHE	267	−19.726	21.654	10.656
ATOM	2950	HB2	PHE	267	−19.863	18.052	7.464
ATOM	2951	HB1	PHE	267	−21.08	17.497	8.627
ATOM	2952	HD1	PHE	267	−17.987	19.679	8.502
ATOM	2953	HD2	PHE	267	−21.845	19.02	10.305
ATOM	2954	HE1	PHE	267	−17.792	21.824	9.721
ATOM	2955	HE2	PHE	267	−21.675	21.19	11.46
ATOM	2956	HZ	PHE	267	−19.645	22.603	11.174
ATOM	2957	H	PHE	267	−20.2	15.316	8.144
ATOM	2958	HA	PHE	267	−18.034	17.138	8.776
ATOM	2959	N	TYR	268	−20.226	16.396	11.21
ATOM	2960	CA	TYR	268	−20.375	16.46	12.663
ATOM	2961	C	TYR	268	−19.181	15.87	13.371
ATOM	2962	O	TYR	268	−18.662	16.505	14.275
ATOM	2963	CB	TYR	268	−21.644	15.713	13.147
ATOM	2964	CG	TYR	268	−21.773	15.771	14.676
ATOM	2965	CD1	TYR	268	−22.472	16.817	15.289
ATOM	2966	CD2	TYR	268	−21.2	14.773	15.471
ATOM	2967	CE1	TYR	268	−22.671	16.813	16.673
ATOM	2968	CE2	TYR	268	−21.36	14.793	16.859
ATOM	2969	CZ	TYR	268	−22.119	15.803	17.464
ATOM	2970	OH	TYR	268	−22.336	15.823	18.845
ATOM	2971	HB1	TYR	268	−22.531	16.177	12.694
ATOM	2972	HB2	TYR	268	−21.613	14.663	12.824
ATOM	2973	HD1	TYR	268	−22.866	17.634	14.694
ATOM	2974	HD2	TYR	268	−20.628	13.972	15.013
ATOM	2975	HE1	TYR	268	−23.258	17.596	17.14
ATOM	2976	HE2	TYR	268	−20.895	14.018	17.459
ATOM	2977	HH	TYR	268	−22.049	15.037	19.295
ATOM	2978	H	TYR	268	−20.985	16.039	10.666
ATOM	2979	HA	TYR	268	−20.491	17.514	12.957
ATOM	2980	N	ILE	269	−18.733	14.651	12.992
ATOM	2981	CA	ILE	269	−17.61	14.054	13.716
ATOM	2982	C	ILE	269	−16.375	14.912	13.556
ATOM	2983	O	ILE	269	−15.575	14.949	14.477
ATOM	2984	CB	ILE	269	−17.317	12.577	13.297
ATOM	2985	CG1	ILE	269	−16.468	11.779	14.335
ATOM	2986	CG2	ILE	269	−16.598	12.531	11.92
ATOM	2987	CD1	ILE	269	−17.158	11.59	15.715
ATOM	2988	HB	ILE	269	−18.286	12.057	13.2
ATOM	2989	HG23	ILE	269	−17.183	13.093	11.186
ATOM	2990	HG22	ILE	269	−16.492	11.501	11.552
ATOM	2991	HG21	ILE	269	−15.59	12.971	11.975
ATOM	2992	HG12	ILE	269	−15.488	12.261	14.481
ATOM	2993	HG11	ILE	269	−16.289	10.771	13.923
ATOM	2994	HD13	ILE	269	−17.155	12.517	16.306
ATOM	2995	HD12	ILE	269	−16.627	10.826	16.304
ATOM	2996	HD11	ILE	269	−18.199	11.259	15.578
ATOM	2997	H	ILE	269	−19.162	14.158	12.23
ATOM	2998	HA	ILE	269	−17.901	14.069	14.776
ATOM	2999	N	SER	270	−16.18	15.6	12.404
ATOM	3000	CA	SER	270	−14.968	16.396	12.23
ATOM	3001	C	SER	270	−15.128	17.734	12.913
ATOM	3002	O	SER	270	−14.449	17.951	13.904
ATOM	3003	CB	SER	270	−14.614	16.593	10.732
ATOM	3004	OG	SER	270	−15.618	17.396	10.086
ATOM	3005	HB2	SER	270	−13.633	17.092	10.651
ATOM	3006	HB1	SER	270	−14.551	15.602	10.25
ATOM	3007	HG	SER	270	−15.444	17.528	9.159
ATOM	3008	H	SER	270	−16.855	15.61	11.662
ATOM	3009	HA	SER	270	−14.113	15.862	12.682
ATOM	3010	N	CYS	271	−16.001	18.634	12.397
ATOM	3011	CA	CYS	271	−16.184	19.958	13.004
ATOM	3012	C	CYS	271	−14.931	20.469	13.689
ATOM	3013	O	CYS	271	−14.958	20.624	14.9
ATOM	3014	CB	CYS	271	−17.372	19.868	13.999
ATOM	3015	SG	CYS	271	−18.984	19.926	13.16
ATOM	3016	HG	CYS	271	−18.808	19.242	12.447
ATOM	3017	HB2	CYS	271	−17.394	20.726	14.685
ATOM	3018	H	CYS	271	−16.564	18.382	11.602
ATOM	3019	HA	CYS	271	−16.443	20.705	12.236
ATOM	3020	HB1	CYS	271	−17.276	18.94	14.581
ATOM	3021	LPG2	CYS	271	−19.115	20.54	12.9
ATOM	3022	LPG1	CYS	271	−19.493	19.742	13.571
ATOM	3023	N	PRO	272	−13.807	20.75	12.984
ATOM	3024	CA	PRO	272	−12.596	21.169	13.681
ATOM	3025	C	PRO	272	−12.803	22.276	14.69
ATOM	3026	O	PRO	272	−12.167	22.258	15.731
ATOM	3027	CB	PRO	272	−11.746	21.634	12.474
ATOM	3028	CG	PRO	272	−12.217	20.706	11.33
ATOM	3029	CD	PRO	272	−13.749	20.639	11.532
ATOM	3030	HA	PRO	272	−12.146	20.284	14.161
ATOM	3031	HB2	PRO	272	−12.001	22.674	12.209
ATOM	3032	HB1	PRO	272	−10.663	21.572	12.667
ATOM	3033	HG1	PRO	272	−11.93	21.068	10.33
ATOM	3034	HG2	PRO	272	−11.783	19.703	11.486
ATOM	3035	HD1	PRO	272	−14.16	19.708	11.116
ATOM	3036	HD2	PRO	272	−14.246	21.508	11.073
ATOM	3037	N	GLN	273	−13.693	23.252	14.405
ATOM	3038	CA	GLN	273	−13.964	24.3	15.392
ATOM	3039	C	GLN	273	−14.61	23.718	16.633
ATOM	3040	O	GLN	273	−14.292	24.21	17.703
ATOM	3041	CB	GLN	273	−14.881	25.394	14.782
ATOM	3042	CG	GLN	273	−15.195	26.538	15.785
ATOM	3043	CD	GLN	273	−16.036	27.631	15.171
ATOM	3044	OE1	GLN	273	−16.346	27.573	13.992
ATOM	3045	NE2	GLN	273	−16.43	28.658	15.952
ATOM	3046	H	GLN	273	−14.196	23.247	13.539
ATOM	3047	HA	GLN	273	−13.006	24.769	15.674
ATOM	3048	HB2	GLN	273	−14.381	25.817	13.895
ATOM	3049	HB1	GLN	273	−15.819	24.92	14.455
ATOM	3050	HG2	GLN	273	−14.254	26.986	16.139
ATOM	3051	HG1	GLN	273	−15.74	26.136	16.652
ATOM	3052	HE21	GLN	273	−16.174	28.706	16.918
ATOM	3053	HE22	GLN	273	−16.987	29.388	15.555
ATOM	3054	N	ASN	274	−15.499	22.703	16.491
ATOM	3055	CA	ASN	274	−16.151	22.006	17.611
ATOM	3056	C	ASN	274	−17.643	21.973	17.311
ATOM	3057	O	ASN	274	−18.155	23.059	17.092
ATOM	3058	CB	ASN	274	−15.921	22.556	19.045
ATOM	3059	CG	ASN	274	−16.565	21.665	20.079
ATOM	3060	OD1	ASN	274	−16.098	20.552	20.251
ATOM	3061	ND2	ASN	274	−17.624	22.096	20.794
ATOM	3062	H	ASN	274	−15.706	22.354	15.575
ATOM	3063	HA	ASN	274	−15.71	20.999	17.615
ATOM	3064	HB2	ASN	274	−14.848	22.553	19.292
ATOM	3065	HB1	ASN	274	−16.297	23.589	19.109
ATOM	3066	HD21	ASN	274	−17.995	23.016	20.679
ATOM	3067	HD22	ASN	274	−18.033	21.479	21.466
ATOM	3068	N	PRO	275	−18.399	20.839	17.265
ATOM	3069	CA	PRO	275	−19.799	20.896	16.845
ATOM	3070	C	PRO	275	−20.653	22.021	17.376
ATOM	3071	O	PRO	275	−21.452	22.562	16.626
ATOM	3072	CB	PRO	275	−20.29	19.541	17.41
ATOM	3073	CG	PRO	275	−19.074	18.613	17.214
ATOM	3074	CD	PRO	275	−17.873	19.516	17.593
ATOM	3075	HA	PRO	275	−19.837	20.89	15.745
ATOM	3076	HB2	PRO	275	−20.5	19.625	18.489
ATOM	3077	HB1	PRO	275	−21.191	19.168	16.902
ATOM	3078	HG1	PRO	275	−19.132	17.689	17.813
ATOM	3079	HG2	PRO	275	−19.028	18.337	16.149
ATOM	3080	HD1	PRO	275	−16.981	19.21	17.026
ATOM	3081	HD2	PRO	275	−17.682	19.445	18.674
ATOM	3082	N	TYR	276	−20.514	22.382	18.669
ATOM	3083	CA	TYR	276	−21.409	23.384	19.245
ATOM	3084	C	TYR	276	−21.428	24.654	18.426
ATOM	3085	O	TYR	276	−22.442	25.333	18.452
ATOM	3086	CB	TYR	276	−21.031	23.767	20.702
ATOM	3087	CG	TYR	276	−20.837	22.585	21.67
ATOM	3088	CD1	TYR	276	−20.105	22.802	22.844
ATOM	3089	CD2	TYR	276	−21.355	21.305	21.429
ATOM	3090	CE1	TYR	276	−19.844	21.756	23.733
ATOM	3091	CE2	TYR	276	−21.084	20.254	22.31
ATOM	3092	CZ	TYR	276	−20.323	20.469	23.462
ATOM	3093	OH	TYR	276	−20.059	19.395	24.317
ATOM	3094	H	TYR	276	−19.823	21.945	19.244
ATOM	3095	HA	TYR	276	−22.437	22.986	19.235
ATOM	3096	HB1	TYR	276	−20.092	24.34	20.658
ATOM	3097	HB2	TYR	276	−21.809	24.422	21.125
ATOM	3098	HD1	TYR	276	−19.73	23.795	23.072
ATOM	3099	HD2	TYR	276	−21.973	21.101	20.563
ATOM	3100	HE1	TYR	276	−19.267	21.953	24.631
ATOM	3101	HE2	TYR	276	−21.467	19.26	22.102
ATOM	3102	HH	TYR	276	−19.517	19.615	25.067
ATOM	3103	N	CYS	277	−20.342	25.012	17.703
ATOM	3104	CA	CYS	277	−20.393	26.248	16.926
ATOM	3105	C	CYS	277	−21.577	26.246	15.984
ATOM	3106	O	CYS	277	−22.225	27.276	15.891
ATOM	3107	CB	CYS	277	−19.091	26.527	16.129
ATOM	3108	S1	CYS	277	−18.761	25.19	14.934
ATOM	3109	H11	CYS	277	−18.131	25.684	14.325
ATOM	3110	H	CYS	277	−19.504	24.46	17.687
ATOM	3111	HA	CYS	277	−20.524	27.08	17.64
ATOM	3112	HB2	CYS	277	−19.188	27.485	15.592
ATOM	3113	HB1	CYS	277	−18.241	26.596	16.824
ATOM	3114	N	VAL	278	−21.883	25.129	15.278
ATOM	3115	CA	VAL	278	−22.997	25.143	14.326
ATOM	3116	C	VAL	278	−23.751	23.83	14.231
ATOM	3117	O	VAL	278	−24.411	23.635	13.223
ATOM	3118	CB	VAL	278	−22.515	25.595	12.91
ATOM	3119	CG1	VAL	278	−21.866	27.007	12.925
ATOM	3120	CG2	VAL	278	−21.531	24.564	12.292
ATOM	3121	H	VAL	278	−21.338	24.293	15.369
ATOM	3122	HA	VAL	278	−23.771	25.846	14.672
ATOM	3123	HB	VAL	278	−23.39	25.657	12.24
ATOM	3124	HG23	VAL	278	−20.626	24.471	12.907
ATOM	3125	HG22	VAL	278	−21.231	24.88	11.281
ATOM	3126	HG21	VAL	278	−22	23.573	12.213
ATOM	3127	HG13	VAL	278	−22.556	27.744	13.364
ATOM	3128	HG12	VAL	278	−21.632	27.329	11.899
ATOM	3129	HG11	VAL	278	−20.93	27.004	13.501
ATOM	3130	N	CYS	279	−23.724	22.904	15.219
ATOM	3131	CA	CYS	279	−24.498	21.667	15.072
ATOM	3132	C	CYS	279	−25.96	21.975	15.316
ATOM	3133	O	CYS	279	−26.532	21.531	16.299
ATOM	3134	CB	CYS	279	−23.941	20.504	15.941
ATOM	3135	SG	CYS	279	−23.801	20.88	17.723
ATOM	3136	HG	CYS	279	−24.777	20.99	17.946
ATOM	3137	H	CYS	279	−23.22	23.059	16.071
ATOM	3138	HA	CYS	279	−24.424	21.302	14.033
ATOM	3139	HB2	CYS	279	−22.924	20.276	15.588
ATOM	3140	HB1	CYS	279	−24.563	19.604	15.814
ATOM	3141	LPG2	CYS	279	−23.45	21.45	17.835
ATOM	3142	LPG1	CYS	279	−23.519	20.368	18.069
ATOM	3143	N	PHE	280	−26.601	22.748	14.41
ATOM	3144	CA	PHE	280	−28.001	23.112	14.609
ATOM	3145	C	PHE	280	−28.843	21.885	14.345
ATOM	3146	O	PHE	280	−29.387	21.786	13.257
ATOM	3147	CB	PHE	280	−28.397	24.292	13.679
ATOM	3148	CG	PHE	280	−27.508	25.517	13.949
ATOM	3149	CD1	PHE	280	−26.582	25.959	12.996
ATOM	3150	CD2	PHE	280	−27.623	26.209	15.16
ATOM	3151	CE1	PHE	280	−25.806	27.096	13.238
ATOM	3152	CE2	PHE	280	−26.807	27.313	15.427
ATOM	3153	CZ	PHE	280	−25.899	27.76	14.464
ATOM	3154	H	PHE	280	−26.138	23.049	13.573
ATOM	3155	HA	PHE	280	−28.158	23.438	15.65
ATOM	3156	HB2	PHE	280	−29.448	24.57	13.858
ATOM	3157	HB1	PHE	280	−28.307	23.98	12.626
ATOM	3158	HD1	PHE	280	−26.458	25.424	12.059
ATOM	3159	HD2	PHE	280	−28.349	25.896	15.902
ATOM	3160	HE1	PHE	280	−25.129	27.466	12.474
ATOM	3161	HE2	PHE	280	−26.879	27.824	16.382
ATOM	3162	HZ	PHE	280	−25.268	28.62	14.667
ATOM	3163	N	MET	281	−28.948	20.956	15.328
ATOM	3164	CA	MET	281	−29.617	19.666	15.127
ATOM	3165	C	MET	281	−30.707	19.631	14.079
ATOM	3166	O	MET	281	−30.817	18.608	13.425
ATOM	3167	CB	MET	281	−30.181	19.083	16.453
ATOM	3168	CG	MET	281	−31.31	19.962	17.05
ATOM	3169	SD	MET	281	−31.967	19.225	18.585
ATOM	3170	CE	MET	281	−30.617	19.495	19.777
ATOM	3171	HB2	MET	281	−30.577	18.07	16.27
ATOM	3172	HB1	MET	281	−29.355	18.996	17.176
ATOM	3173	HG2	MET	281	−32.16	20.016	16.354
ATOM	3174	HG1	MET	281	−30.953	20.983	17.254
ATOM	3175	HE3	MET	281	−30.993	19.275	20.787
ATOM	3176	HE2	MET	281	−29.772	18.826	19.561
ATOM	3177	HE1	MET	281	−30.28	20.542	19.738
ATOM	3178	H	MET	281	−28.456	21.092	16.193
ATOM	3179	HA	MET	281	−28.826	18.979	14.778
ATOM	3180	LPD2	MET	281	−32.092	18.562	18.504
ATOM	3181	LPD1	MET	281	−32.535	19.539	18.783
ATOM	3182	N	SER	282	−31.516	20.692	13.865
ATOM	3183	CA	SER	282	−32.454	20.672	12.745
ATOM	3184	C	SER	282	−31.805	20.127	11.489
ATOM	3185	O	SER	282	−32.402	19.279	10.847
ATOM	3186	CB	SER	282	−32.988	22.096	12.447
ATOM	3187	OG	SER	282	−33.617	22.602	13.638
ATOM	3188	HB2	SER	282	−32.148	22.75	12.157
ATOM	3189	HB1	SER	282	−33.711	22.054	11.615
ATOM	3190	HG	SER	282	−33.965	23.482	13.527
ATOM	3191	H	SER	282	−31.46	21.515	14.432
ATOM	3192	HA	SER	282	−33.309	20.036	13.027
ATOM	3193	N	HIS	283	−30.585	20.575	11.11
ATOM	3194	CA	HIS	283	−29.962	20.038	9.896
ATOM	3195	C	HIS	283	−29.666	18.553	9.983
ATOM	3196	O	HIS	283	−29.598	17.917	8.944
ATOM	3197	CB	HIS	283	−28.743	20.874	9.406
ATOM	3198	CG	HIS	283	−27.576	21.127	10.335
ATOM	3199	ND1	HIS	283	−26.58	21.904	9.967
ATOM	3200	CD2	HIS	283	−27.346	20.665	11.581
ATOM	3201	CE1	HIS	283	−25.702	21.982	10.915
ATOM	3202	NE2	HIS	283	−26.087	21.289	11.886
ATOM	3203	HB2	HIS	283	−28.345	20.41	8.49
ATOM	3204	HB1	HIS	283	−29.123	21.873	9.14
ATOM	3205	HD1	HIS	283	−26.505	22.383	9.057
ATOM	3206	HD2	HIS	283	−27.907	20.005	12.232
ATOM	3207	HE1	HIS	283	−24.773	22.552	10.891
ATOM	3208	H	HIS	283	−30.092	21.254	11.659
ATOM	3209	HA	HIS	283	−30.714	20.118	9.091
ATOM	3210	N	PHE	284	−29.508	17.958	11.183
ATOM	3211	CA	PHE	284	−29.337	16.507	11.297
ATOM	3212	C	PHE	284	−30.708	15.872	11.305
ATOM	3213	O	PHE	284	−30.951	14.95	10.541
ATOM	3214	CB	PHE	284	−28.587	16.192	12.619
ATOM	3215	CG	PHE	284	−28.317	14.7	12.86
ATOM	3216	CD1	PHE	284	−27.292	14.047	12.166
ATOM	3217	CD2	PHE	284	−29.066	13.982	13.801
ATOM	3218	CE1	PHE	284	−26.898	12.759	12.539
ATOM	3219	CE2	PHE	284	−28.669	12.697	14.183
ATOM	3220	CZ	PHE	284	−27.563	12.097	13.575
ATOM	3221	HB2	PHE	284	−29.14	16.592	13.482
ATOM	3222	HB1	PHE	284	−27.62	16.713	12.593
ATOM	3223	HD1	PHE	284	−26.795	14.543	11.341
ATOM	3224	HD2	PHE	284	−29.951	14.423	14.248
ATOM	3225	HE1	PHE	284	−26.075	12.273	12.024
ATOM	3226	HE2	PHE	284	−29.219	12.166	14.953
ATOM	3227	HZ	PHE	284	−27.227	11.118	13.902
ATOM	3228	H	PHE	284	−29.602	18.487	12.022
ATOM	3229	HA	PHE	284	−28.742	16.112	10.456
ATOM	3230	N	ASN	285	−31.625	16.364	12.169
ATOM	3231	CA	ASN	285	−32.958	15.781	12.259
ATOM	3232	C	ASN	285	−33.633	15.809	10.908
ATOM	3233	O	ASN	285	−34.15	14.787	10.493
ATOM	3234	CB	ASN	285	−33.847	16.546	13.278
ATOM	3235	CG	ASN	285	−33.214	16.614	14.647
ATOM	3236	OD1	ASN	285	−32.181	16.001	14.863
ATOM	3237	ND2	ASN	285	−33.807	17.357	15.604
ATOM	3238	HB2	ASN	285	−34.01	17.575	12.922
ATOM	3239	HB1	ASN	285	−34.825	16.048	13.363
ATOM	3240	HD21	ASN	285	−34.653	17.861	15.425
ATOM	3241	HD22	ASN	285	−33.391	17.404	16.513
ATOM	3242	H	ASN	285	−31.407	17.124	12.78
ATOM	3243	HA	ASN	285	−32.856	14.74	12.607
ATOM	3244	N	LEU	286	−33.644	16.955	10.194
ATOM	3245	CA	LEU	286	−34.325	17.008	8.898
ATOM	3246	C	LEU	286	−33.828	15.894	8.005
ATOM	3247	O	LEU	286	−34.629	15.217	7.378
ATOM	3248	CB	LEU	286	−34.078	18.36	8.166
ATOM	3249	CG	LEU	286	−34.83	19.573	8.798
ATOM	3250	CD1	LEU	286	−34.195	20.905	8.307
ATOM	3251	CD2	LEU	286	−36.347	19.566	8.454
ATOM	3252	HB2	LEU	286	−32.991	18.541	8.174
ATOM	3253	HB1	LEU	286	−34.386	18.274	7.111
ATOM	3254	HG	LEU	286	−34.737	19.544	9.896
ATOM	3255	HD13	LEU	286	−33.137	20.966	8.607
ATOM	3256	HD12	LEU	286	−34.719	21.771	8.741
ATOM	3257	HD11	LEU	286	−34.252	20.974	7.209
ATOM	3258	HD23	LEU	286	−36.495	19.596	7.363
ATOM	3259	HD22	LEU	286	−36.841	20.447	8.893
ATOM	3260	HD21	LEU	286	−36.851	18.672	8.849
ATOM	3261	H	LEU	286	−33.18	17.772	10.54
ATOM	3262	HA	LEU	286	−35.401	16.848	9.061
ATOM	3263	N	TYR	287	−32.498	15.682	7.927
ATOM	3264	CA	TYR	287	−31.994	14.611	7.07
ATOM	3265	C	TYR	287	−32.306	13.262	7.688
ATOM	3266	O	TYR	287	−32.53	12.31	6.957
ATOM	3267	CB	TYR	287	−30.481	14.804	6.802
ATOM	3268	CG	TYR	287	−30.091	16.239	6.4
ATOM	3269	CD1	TYR	287	−30.988	17.158	5.841
ATOM	3270	CD2	TYR	287	−28.77	16.644	6.617
ATOM	3271	CE1	TYR	287	−30.585	18.472	5.583
ATOM	3272	CE2	TYR	287	−28.353	17.946	6.327
ATOM	3273	CZ	TYR	287	−29.271	18.877	5.829
ATOM	3274	OH	TYR	287	−28.903	20.201	5.572
ATOM	3275	HB1	TYR	287	−29.956	14.563	7.738
ATOM	3276	HB2	TYR	287	−30.14	14.115	6.015
ATOM	3277	HD1	TYR	287	−32.005	16.877	5.597
ATOM	3278	HD2	TYR	287	−28.061	15.937	7.025
ATOM	3279	HE1	TYR	287	−31.298	19.188	5.187
ATOM	3280	HE2	TYR	287	−27.318	18.226	6.496
ATOM	3281	HH	TYR	287	−27.972	20.371	5.662
ATOM	3282	H	TYR	287	−31.852	16.222	8.473
ATOM	3283	HA	TYR	287	−32.507	14.655	6.097
ATOM	3284	N	LEU	288	−32.351	13.153	9.035
ATOM	3285	CA	LEU	288	−32.8	11.907	9.665
ATOM	3286	C	LEU	288	−34.213	11.638	9.184
ATOM	3287	O	LEU	288	−34.513	10.532	8.765
ATOM	3288	CB	LEU	288	−32.762	12.016	11.22
ATOM	3289	CG	LEU	288	−32.614	10.675	12.001
ATOM	3290	CD1	LEU	288	−32.499	10.989	13.521
ATOM	3291	CD2	LEU	288	−33.8	9.704	11.759
ATOM	3292	HB2	LEU	288	−31.89	12.625	11.5
ATOM	3293	HB1	LEU	288	−33.659	12.542	11.577
ATOM	3294	HG	LEU	288	−31.684	10.168	11.687
ATOM	3295	HD13	LEU	288	−31.627	11.628	13.727
ATOM	3296	HD12	LEU	288	−32.381	10.06	14.093
ATOM	3297	HD11	LEU	288	−33.404	11.503	13.879
ATOM	3298	HD23	LEU	288	−34.755	10.222	11.935
ATOM	3299	HD22	LEU	288	−33.738	8.84	12.439
ATOM	3300	HD21	LEU	288	−33.78	9.313	10.733
ATOM	3301	H	LEU	288	−32.125	13.938	9.613
ATOM	3302	HA	LEU	288	−32.126	11.098	9.344
ATOM	3303	N	ILE	289	−35.11	12.652	9.217
ATOM	3304	CA	ILE	289	−36.47	12.441	8.723
ATOM	3305	C	ILE	289	−36.349	11.988	7.286
ATOM	3306	O	ILE	289	−36.954	10.99	6.924
ATOM	3307	CB	ILE	289	−37.408	13.69	8.839
ATOM	3308	CG1	ILE	289	−38.055	13.84	10.252
ATOM	3309	CG2	ILE	289	−38.557	13.628	7.788
ATOM	3310	CD1	ILE	289	−37.038	14.014	11.409
ATOM	3311	HB	ILE	289	−36.828	14.601	8.62
ATOM	3312	HG23	ILE	289	−38.172	13.687	6.758
ATOM	3313	HG22	ILE	289	−39.253	14.471	7.92
ATOM	3314	HG21	ILE	289	−39.116	12.686	7.901
ATOM	3315	HG12	ILE	289	−38.695	12.967	10.448
ATOM	3316	HG11	ILE	289	−38.71	14.729	10.265
ATOM	3317	HD13	ILE	289	−36.324	13.18	11.455
ATOM	3318	HD12	ILE	289	−37.568	14.056	12.372
ATOM	3319	HD11	ILE	289	−36.489	14.959	11.281
ATOM	3320	H	ILE	289	−34.842	13.564	9.527
ATOM	3321	HA	ILE	289	−36.92	11.614	9.29
ATOM	3322	N	LEU	290	−35.578	12.718	6.448
ATOM	3323	CA	LEU	290	−35.505	12.346	5.038
ATOM	3324	C	LEU	290	−35.101	10.9	4.888
ATOM	3325	O	LEU	290	−35.69	10.239	4.046
ATOM	3326	CB	LEU	290	−34.503	13.215	4.23
ATOM	3327	CG	LEU	290	−34.426	12.865	2.712
ATOM	3328	CD1	LEU	290	−35.769	13.103	1.967
ATOM	3329	CD2	LEU	290	−33.298	13.698	2.043
ATOM	3330	HB2	LEU	290	−34.764	14.278	4.352
ATOM	3331	HB1	LEU	290	−33.505	13.05	4.663
ATOM	3332	HG	LEU	290	−34.158	11.801	2.603
ATOM	3333	HD13	LEU	290	−36.553	12.415	2.314
ATOM	3334	HD12	LEU	290	−35.641	12.931	0.887
ATOM	3335	HD11	LEU	290	−36.111	14.138	2.118
ATOM	3336	HD23	LEU	290	−33.496	14.775	2.154
ATOM	3337	HD22	LEU	290	−33.228	13.466	0.969
ATOM	3338	HD21	LEU	290	−32.328	13.467	2.51
ATOM	3339	H	LEU	290	−35.089	13.534	6.768
ATOM	3340	HA	LEU	290	−36.519	12.488	4.635
ATOM	3341	N	ILE	291	−34.119	10.385	5.666
ATOM	3342	CA	ILE	291	−33.716	8.99	5.483
ATOM	3343	C	ILE	291	−34.941	8.117	5.363
ATOM	3344	O	ILE	291	−35.027	7.347	4.421
ATOM	3345	CB	ILE	291	−32.799	8.401	6.603
ATOM	3346	CG1	ILE	291	−31.328	8.868	6.392
ATOM	3347	CG2	ILE	291	−32.886	6.844	6.594
ATOM	3348	CD1	ILE	291	−30.391	8.598	7.602
ATOM	3349	HB	ILE	291	−33.153	8.756	7.584
ATOM	3350	HG23	ILE	291	−33.87	6.484	6.931
ATOM	3351	HG22	ILE	291	−32.155	6.387	7.262
ATOM	3352	HG21	ILE	291	−32.7	6.467	5.577
ATOM	3353	HG12	ILE	291	−31.306	9.951	6.188
ATOM	3354	HG11	ILE	291	−30.93	8.356	5.502
ATOM	3355	HD13	ILE	291	−30.655	9.252	8.446
ATOM	3356	HD12	ILE	291	−29.36	8.806	7.295
ATOM	3357	HD11	ILE	291	−30.399	7.562	7.96
ATOM	3358	H	ILE	291	−33.643	10.949	6.346
ATOM	3359	HA	ILE	291	−33.166	8.93	4.533
ATOM	3360	N	MET	292	−35.898	8.207	6.31
ATOM	3361	CA	MET	292	−37.006	7.253	6.299
ATOM	3362	C	MET	292	−37.866	7.348	5.056
ATOM	3363	O	MET	292	−38.731	6.499	4.906
ATOM	3364	CB	MET	292	−37.812	7.285	7.628
ATOM	3365	CG	MET	292	−36.956	6.736	8.805
ATOM	3366	SD	MET	292	−37.889	6.871	10.368
ATOM	3367	CE	MET	292	−36.817	7.972	11.348
ATOM	3368	HB2	MET	292	−38.126	8.32	7.829
ATOM	3369	HB1	MET	292	−38.719	6.665	7.539
ATOM	3370	HG2	MET	292	−36.002	7.279	8.885
ATOM	3371	HG1	MET	292	−36.73	5.669	8.65
ATOM	3372	HE3	MET	292	−35.915	7.446	11.676
ATOM	3373	HE2	MET	292	−37.365	8.306	12.238
ATOM	3374	HE1	MET	292	−36.523	8.846	10.751
ATOM	3375	H	MET	292	−35.847	8.91	7.025
ATOM	3376	HA	MET	292	−36.573	6.241	6.229
ATOM	3377	LPD2	MET	292	−37.961	6.266	10.666
ATOM	3378	LPD1	MET	292	−38.501	7.148	10.267
ATOM	3379	N	CYS	293	−37.666	8.3	4.114
ATOM	3380	CA	CYS	293	−38.315	8.147	2.814
ATOM	3381	C	CYS	293	−37.839	6.865	2.162
ATOM	3382	O	CYS	293	−38.598	6.318	1.378
ATOM	3383	CB	CYS	293	−38.108	9.353	1.857
ATOM	3384	SG	CYS	293	−36.395	9.489	1.247
ATOM	3385	HB2	CYS	293	−38.771	9.256	0.982
ATOM	3386	HB1	CYS	293	−38.365	10.286	2.383
ATOM	3387	H	CYS	293	−37.018	9.053	4.233
ATOM	3388	HG	CYS	293	−36.339	8.624	0.733
ATOM	3389	HA	CYS	293	−39.4	8.06	2.994
ATOM	3390	LPG2	CYS	293	−35.945	9.511	1.755
ATOM	3391	LPG1	CYS	293	−36.31	10.029	0.845
ATOM	3392	N	ASN	294	−36.621	6.346	2.467
ATOM	3393	CA	ASN	294	−36.222	5.033	1.949
ATOM	3394	C	ASN	294	−37.375	4.071	2.099
ATOM	3395	O	ASN	294	−37.663	3.312	1.187
ATOM	3396	CB	ASN	294	−34.971	4.424	2.649
ATOM	3397	CG	ASN	294	−35.207	3.995	4.08
ATOM	3398	OD1	ASN	294	−34.839	4.72	4.989
ATOM	3399	ND2	ASN	294	−35.814	2.817	4.339
ATOM	3400	HB2	ASN	294	−34.641	3.536	2.086
ATOM	3401	HB1	ASN	294	−34.147	5.154	2.622
ATOM	3402	HD21	ASN	294	−36.095	2.177	3.62
ATOM	3403	HD22	ASN	294	−35.994	2.557	5.288
ATOM	3404	H	ASN	294	−35.981	6.827	3.069
ATOM	3405	HA	ASN	294	−35.976	5.151	0.885
ATOM	3406	N	SER	295	−38.045	4.119	3.271
ATOM	3407	CA	SER	295	−39.128	3.186	3.549
ATOM	3408	C	SER	295	−40.211	3.186	2.493
ATOM	3409	O	SER	295	−40.818	2.147	2.284
ATOM	3410	CB	SER	295	−39.75	3.572	4.914
ATOM	3411	OG	SER	295	−38.694	3.858	5.849
ATOM	3412	HB2	SER	295	−40.385	4.465	4.785
ATOM	3413	HB1	SER	295	−40.362	2.743	5.291
ATOM	3414	HG	SER	295	−39.026	4.164	6.687
ATOM	3415	H	SER	295	−37.788	4.763	3.997
ATOM	3416	HA	SER	295	−38.684	2.185	3.616
ATOM	3417	N	ILE	296	−40.471	4.345	1.843
ATOM	3418	CA	ILE	296	−41.522	4.436	0.826
ATOM	3419	C	ILE	296	−40.941	4.437	−0.576
ATOM	3420	O	ILE	296	−41.57	3.881	−1.465
ATOM	3421	CB	ILE	296	−42.429	5.688	1.078
ATOM	3422	CG1	ILE	296	−41.842	7.01	0.493
ATOM	3423	CG2	ILE	296	−42.739	5.818	2.599
ATOM	3424	CD1	ILE	296	−42.794	8.232	0.609
ATOM	3425	HB	ILE	296	−43.383	5.516	0.547
ATOM	3426	HG23	ILE	296	−43.13	4.865	2.984
ATOM	3427	HG22	ILE	296	−43.491	6.593	2.788
ATOM	3428	HG21	ILE	296	−41.842	6.085	3.175
ATOM	3429	HG12	ILE	296	−41.651	6.879	−0.585
ATOM	3430	HG11	ILE	296	−40.892	7.258	0.986
ATOM	3431	HD13	ILE	296	−43.784	7.991	0.192
ATOM	3432	HD12	ILE	296	−42.378	9.083	0.047
ATOM	3433	HD11	ILE	296	−42.917	8.554	1.652
ATOM	3434	H	ILE	296	−39.942	5.168	2.052
ATOM	3435	HA	ILE	296	−42.186	3.555	0.898
ATOM	3436	N	ILE	297	−39.767	5.063	−0.84
ATOM	3437	CA	ILE	297	−39.318	5.197	−2.225
ATOM	3438	C	ILE	297	−38.916	3.876	−2.847
ATOM	3439	O	ILE	297	−39.017	3.783	−4.061
ATOM	3440	CB	ILE	297	−38.332	6.377	−2.515
ATOM	3441	CG1	ILE	297	−36.963	6.354	−1.769
ATOM	3442	CG2	ILE	297	−39.029	7.74	−2.222
ATOM	3443	CD1	ILE	297	−36.122	5.068	−1.977
ATOM	3444	HB	ILE	297	−38.112	6.358	−3.596
ATOM	3445	HG23	ILE	297	−39.96	7.848	−2.801
ATOM	3446	HG22	ILE	297	−38.371	8.581	−2.489
ATOM	3447	HG21	ILE	297	−39.274	7.821	−1.153
ATOM	3448	HG12	ILE	297	−37.115	6.525	−0.696
ATOM	3449	HG11	ILE	297	−36.36	7.201	−2.138
ATOM	3450	HD13	ILE	297	−36.528	4.244	−1.38
ATOM	3451	HD12	ILE	297	−35.085	5.234	−1.644
ATOM	3452	HD11	ILE	297	−36.102	4.765	−3.033
ATOM	3453	H	ILE	297	−39.203	5.466	−0.12
ATOM	3454	HA	ILE	297	−40.215	5.476	−2.8
ATOM	3455	N	ASP	298	−38.479	2.839	−2.092
ATOM	3456	CA	ASP	298	−38.113	1.579	−2.747
ATOM	3457	C	ASP	298	−39.376	0.892	−3.243
ATOM	3458	O	ASP	298	−39.465	0.692	−4.447
ATOM	3459	CB	ASP	298	−37.157	0.66	−1.924
ATOM	3460	CG	ASP	298	−35.703	0.898	−2.248
ATOM	3461	OD1	ASP	298	−35.282	2.085	−2.264
ATOM	3462	OD2	ASP	298	−34.969	−0.098	−2.498
ATOM	3463	HB2	ASP	298	−37.255	0.82	−0.841
ATOM	3464	HB1	ASP	298	−37.39	−0.394	−2.142
ATOM	3465	H	ASP	298	−38.43	2.903	−1.093
ATOM	3466	HA	ASP	298	−37.539	1.829	−3.656
ATOM	3467	N	PRO	299	−40.396	0.513	−2.428
ATOM	3468	CA	PRO	299	−41.613	−0.039	−3.009
ATOM	3469	C	PRO	299	−42.226	0.821	−4.086
ATOM	3470	O	PRO	299	−42.71	0.277	−5.065
ATOM	3471	CB	PRO	299	−42.547	−0.048	−1.777
ATOM	3472	CG	PRO	299	−41.569	−0.24	−0.603
ATOM	3473	CD	PRO	299	−40.355	0.643	−0.976
ATOM	3474	HB2	PRO	299	−43.317	−0.834	−1.832
ATOM	3475	HB1	PRO	299	−43.038	0.931	−1.651
ATOM	3476	HG1	PRO	299	−42.022	0.037	0.361
ATOM	3477	HG2	PRO	299	−41.264	−1.3	−0.585
ATOM	3478	HD1	PRO	299	−40.528	1.683	−0.667
ATOM	3479	HD2	PRO	299	−39.453	0.245	−0.493
ATOM	3480	HA	PRO	299	−41.416	−1.065	−3.36
ATOM	3481	N	LEU	300	−42.233	2.163	−3.918
ATOM	3482	CA	LEU	300	−42.882	3.011	−4.917
ATOM	3483	C	LEU	300	−42.097	2.927	−6.204
ATOM	3484	O	LEU	300	−42.668	2.59	−7.229
ATOM	3485	CB	LEU	300	−43.034	4.466	−4.385
ATOM	3486	CG	LEU	300	−43.8	5.451	−5.322
ATOM	3487	CD1	LEU	300	−44.354	6.642	−4.487
ATOM	3488	CD2	LEU	300	−42.902	6.018	−6.462
ATOM	3489	HB2	LEU	300	−43.58	4.379	−3.431
ATOM	3490	HB1	LEU	300	−42.045	4.886	−4.162
ATOM	3491	HG	LEU	300	−44.663	4.926	−5.766
ATOM	3492	HD13	LEU	300	−45.054	6.286	−3.714
ATOM	3493	HD12	LEU	300	−44.896	7.352	−5.131
ATOM	3494	HD11	LEU	300	−43.529	7.176	−3.99
ATOM	3495	HD23	LEU	300	−42.039	6.554	−6.039
ATOM	3496	HD22	LEU	300	−43.478	6.724	−7.08
ATOM	3497	HD21	LEU	300	−42.524	5.236	−7.13
ATOM	3498	H	LEU	300	−41.807	2.588	−3.113
ATOM	3499	HA	LEU	300	−43.899	2.621	−5.094
ATOM	3500	N	ILE	301	−40.779	3.225	−6.191
ATOM	3501	CA	ILE	301	−40.021	3.178	−7.444
ATOM	3502	C	ILE	301	−40.151	1.795	−8.033
ATOM	3503	O	ILE	301	−40.337	1.683	−9.234
ATOM	3504	CB	ILE	301	−38.528	3.577	−7.259
ATOM	3505	CG1	ILE	301	−38.429	5.102	−6.949
ATOM	3506	CG2	ILE	301	−37.686	3.208	−8.517
ATOM	3507	CD1	ILE	301	−37.08	5.501	−6.298
ATOM	3508	H	ILE	301	−40.311	3.446	−5.332
ATOM	3509	HB	ILE	301	−38.14	3.001	−6.405
ATOM	3510	HG12	ILE	301	−39.223	5.402	−6.246
ATOM	3511	HG11	ILE	301	−38.576	5.679	−7.877
ATOM	3512	HG23	ILE	301	−37.666	2.118	−8.667
ATOM	3513	HG22	ILE	301	−36.645	3.539	−8.416
ATOM	3514	HG21	ILE	301	−38.113	3.677	−9.416
ATOM	3515	HD13	ILE	301	−36.945	4.959	−5.352
ATOM	3516	HD12	ILE	301	−37.089	6.581	−6.09
ATOM	3517	HD11	ILE	301	−36.219	5.283	−6.941
ATOM	3518	HA	ILE	301	−40.476	3.886	−8.157
ATOM	3519	N	TYR	302	−40.066	0.724	−7.215
ATOM	3520	CA	TYR	302	−40.28	−0.611	−7.769
ATOM	3521	C	TYR	302	−41.656	−0.719	−8.386
ATOM	3522	O	TYR	302	−41.766	−1.221	−9.492
ATOM	3523	CB	TYR	302	−40.161	−1.719	−6.691
ATOM	3524	CG	TYR	302	−40.694	−3.068	−7.205
ATOM	3525	CD1	TYR	302	−40.172	−3.648	−8.368
ATOM	3526	CD2	TYR	302	−41.705	−3.741	−6.508
ATOM	3527	CE1	TYR	302	−40.63	−4.894	−8.808
ATOM	3528	CE2	TYR	302	−42.157	−4.99	−6.942
ATOM	3529	CZ	TYR	302	−41.619	−5.576	−8.09
ATOM	3530	OH	TYR	302	−42.075	−6.831	−8.496
ATOM	3531	H	TYR	302	−39.883	0.832	−6.233
ATOM	3532	HB1	TYR	302	−40.738	−1.409	−5.808
ATOM	3533	HB2	TYR	302	−39.11	−1.827	−6.379
ATOM	3534	HD1	TYR	302	−39.4	−3.14	−8.936
ATOM	3535	HD2	TYR	302	−42.145	−3.303	−5.62
ATOM	3536	HE1	TYR	302	−40.209	−5.327	−9.708
ATOM	3537	HE2	TYR	302	−42.931	−5.513	−6.389
ATOM	3538	HH	TYR	302	−42.015	−6.968	−9.435
ATOM	3539	HA	TYR	302	−39.523	−0.777	−8.554
ATOM	3540	N	ALA	303	−42.723	−0.271	−7.693
ATOM	3541	CA	ALA	303	−44.063	−0.397	−8.262
ATOM	3542	C	ALA	303	−44.132	0.332	−9.585
ATOM	3543	O	ALA	303	−44.679	−0.205	−10.536
ATOM	3544	CB	ALA	303	−45.146	0.175	−7.31
ATOM	3545	HB3	ALA	303	−44.975	1.246	−7.127
ATOM	3546	HB2	ALA	303	−45.121	−0.356	−6.346
ATOM	3547	HB1	ALA	303	−46.146	0.051	−7.755
ATOM	3548	H	ALA	303	−42.612	0.153	−6.793
ATOM	3549	HA	ALA	303	−44.273	−1.468	−8.427
ATOM	3550	N	LEU	304	−43.578	1.561	−9.668
ATOM	3551	CA	LEU	304	−43.591	2.283	−10.941
ATOM	3552	C	LEU	304	−42.663	1.617	−11.937
ATOM	3553	O	LEU	304	−42.984	1.644	−13.115
ATOM	3554	CB	LEU	304	−43.199	3.782	−10.777
ATOM	3555	CG	LEU	304	−44.358	4.721	−10.312
ATOM	3556	CD1	LEU	304	−45.376	5.02	−11.451
ATOM	3557	CD2	LEU	304	−45.109	4.193	−9.059
ATOM	3558	HB2	LEU	304	−42.352	3.85	−10.075
ATOM	3559	HB1	LEU	304	−42.836	4.167	−11.745
ATOM	3560	HG	LEU	304	−43.898	5.689	−10.04
ATOM	3561	HD13	LEU	304	−44.862	5.415	−12.34
ATOM	3562	HD12	LEU	304	−46.103	5.778	−11.117
ATOM	3563	HD11	LEU	304	−45.938	4.121	−11.743
ATOM	3564	HD23	LEU	304	−45.626	3.246	−9.272
ATOM	3565	HD22	LEU	304	−45.86	4.927	−8.726
ATOM	3566	HD21	LEU	304	−44.409	4.034	−8.23
ATOM	3567	H	LEU	304	−43.119	1.964	−8.871
ATOM	3568	HA	LEU	304	−44.601	2.222	−11.375
ATOM	3569	N	ARG	305	−41.516	1.031	−11.519
ATOM	3570	CA	ARG	305	−40.582	0.436	−12.475
ATOM	3571	C	ARG	305	−40.191	−0.947	−12.018
ATOM	3572	O	ARG	305	−39.023	−1.299	−11.937
ATOM	3573	CB	ARG	305	−39.362	1.378	−12.68
ATOM	3574	CG	ARG	305	−39.837	2.832	−12.968
ATOM	3575	CD	ARG	305	−38.739	3.727	−13.611
ATOM	3576	NE	ARG	305	−38.524	3.397	−15.027
ATOM	3577	CZ	ARG	305	−37.827	4.141	−15.859
ATOM	3578	NH1	ARG	305	−37.203	5.233	−15.487
ATOM	3579	NH2	ARG	305	−37.753	3.781	−17.12
ATOM	3580	HB2	ARG	305	−38.739	1.381	−11.77
ATOM	3581	HB1	ARG	305	−38.749	0.99	−13.508
ATOM	3582	HG2	ARG	305	−40.171	3.277	−12.014
ATOM	3583	HG1	ARG	305	−40.701	2.827	−13.652
ATOM	3584	HD2	ARG	305	−37.803	3.63	−13.036
ATOM	3585	HD1	ARG	305	−39.115	4.761	−13.53
ATOM	3586	HE	ARG	305	−38.986	2.548	−15.388
ATOM	3587	HH21	ARG	305	−38.224	2.931	−17.463
ATOM	3588	HH22	ARG	305	−37.228	4.343	−17.807
ATOM	3589	HH11	ARG	305	−37.214	5.555	−14.514
ATOM	3590	HH12	ARG	305	−36.672	5.8	−16.164
ATOM	3591	H	ARG	305	−41.259	1.026	−10.551
ATOM	3592	HA	ARG	305	−41.055	0.281	−13.459
ATOM	3593	H13	ARG	305	−40.975	−1.661	−11.771

The data shown in Table 1 are expressed based on the Protein Data Bank (PDB) format: The PDB format is a format containing coordinates (X, Y, Z,), etc. of individual atoms constituting a protein, and is one of the standard formats in handling coordinates of biopolymers. In Table 1, the “ATOM” appearing in the utmost left column (1st column) denotes each atom of the atomic coordinates. The numbers (1, 2, 3, . . . 3593) appearing in the next column (2nd column) are serial numbers of individual atoms. Subsequently, in the left to right direction in this Table, there are denoted the type of each atom and its position in the amino acid to which it belongs (e.g., “CB”, “CG”, “SD”) (in the 3rd column); the amino acid residue to which each atom belongs (three-letter abbreviations for amino acids, e.g. “MET”, “ASN”) (in the 4th column); the sequence number of the residue counted from the N-terminal (in the 5th column); X-coordinate (in angstrom unit) (in the 6th column); Y-coordinate (in angstrom unit) (in the 7th column); Z-coordinate (in angstrom unit)(in the 8th column).

In addition to the above-described atomic coordinates, the present invention also includes derivatives therefrom, i.e., derivatives from the above-mentioned atomic coordinates (related receptors, etc.) obtained by techniques such as homology modeling on computer. The term “derivatives” means proteins of the GPCR family that have 15% or more, preferably 30% or more, homology to native human MC4-R in the amino acid sequence; or atomic coordinates (derived coordinates) in which a part of the amino acid sequence of native human MC4-R (preferably one or several (e.g., one to ten) amino acids) is deleted, substituted or added and which exhibit a three-dimensional structure of a protein having activity functionally equivalent to native human MC4-R (i.e., the signal transduction activity of GPCRs). Further, in the case of a GPCR family protein that is too low in homology to make an alignment of amino acid sequences with human MC4-R in all regions, modeling may be performed on the seven helix sites alone that can be determined using hydrophobicity or the like as an indicator. Whether a given set of atomic coordinates constituting a mutated GPCR amino acid sequence is included as a derivative of the present invention can be analyzed by comparing the three-dimensional structure of the GPCR in question and native human MC4-R (as represented by Table 1) by using as a parameter the discrepancies between the positions of α carbon atoms of specific amino acid residues.

Specifically, an image of the three-dimensional structure composed of the atomic coordinates of native human MC4-R (designated “three-dimensional structure I”) and an image of the three-dimensional structure composed of the derived coordinates in question (designated “three-dimensional structure II”) are created on computer based on the two sets of atomic coordinates. Subsequently, one image is superimposed on the other image on a computer display. The image of three-dimensional structure I contains seven helix sites of human MC4-R. These regions are superimposed on the regions of the corresponding helix sites in the image of three-dimensional structure II, or vice versa. This superimposition may be processed automatically based on a computer program, or may be carried out manually on a computer display in a manner similar to the one employed in comparing fingerprints. A suitable program includes COMPOSER or MODELER.

The seven helix sites (regions) and three extra-cellular sites (regions) of human MC4-R include the first helix (expressed as “HI(41-70)”) consisting of an amino acid sequence from position 41 to position 70 (SEQ ID NO: 2) of the amino acid sequence as shown in SEQ ID NO: 1 (hereinafter, all the position numbers mentioned in this paragraph refer to position numbers in SEQ ID NO: 1), the second helix (expressed as “HII (78-107)”) consisting of an amino acid sequence from position 78 to position 107 (SEQ ID NO: 3), the third helix (expressed as “HIII (120-150)”) consisting of an amino acid sequence from position 120 to position 150 (SEQ ID NO: 4), the fourth helix (expressed as “HIV (163-186)”) consisting of an amino acid sequence from position 163 to position 186 (SEQ ID NO: 5), the fifth helix (expressed as “HV (189-217)”) consisting of an amino acid sequence from position 189 to position 217 (SEQ ID NO: 6), the sixth helix (expressed as “H-VI(239-270)”) consisting of an amino acid sequence from position 239 to position 270 (SEQ ID NO: 7), the seventh helix (expressed as “HVII(282-305)”) consisting of an amino acid sequence from position 282 to position 305 (SEQ ID NO: 8); the first extra-cellular region (expressed as “ECI (108-119)”) consisting of an amino acid sequence from position 107 to position 119 (SEQ ID NO: 9), the second extra-cellular region (expressed as “ECII (187-188)”) consisting of an amino acid sequence from position 187 to position 188 (SEQ ID NO: 10), and the third extra-cellular region (expressed as “ECIII (271-281)”) consisting of an amino acid sequence from position 271 to position 281 (SEQ ID NO: 11). Then, these regions are superimposed on the corresponding regions of the three-dimensional structure II or vice versa, to calculate the discrepancies between the positions of the α carbon atoms in the amino acid residues of those helices in the three-dimensional structure I and the positions of the corresponding α carbon atoms in the amino acid residues of the corresponding helices in the three-dimensional structure II. When the mean residual of the discrepancies is 1.5 Å, preferably 1.0, more preferably 0.5, or less, the three-dimensional structure II is regarded as a derivative of the atomic coordinates as shown in Table 1 (derived coordinates). Discrepancies between the positions of corresponding α carbon atoms can be calculated by the so-called least squares method. Generally, such discrepancies can be calculated using a computer software (e.g., LSQKAB, Quanta). The mean residual is calculated as follows. Briefly, individual distances between two corresponding α carbon atoms are squared; the mean value of these squares is calculated; and then the square root of the mean value is calculated to obtain the mean residual.

An active site or protein-binding site is formed by at least one helix selected from the above-described seven helices. Accordingly, a G protein-coupled receptor that has a three-dimensional structure of that active site or protein-binding site, preferably at least one helix consists of HIII, HV, HVI and HVII, is also included in the G protein-coupled receptor of the invention.

In addition to the GPCR (human MC4-R) having the three-dimensional structure consisting of the atomic coordinates as shown in Table 1, the present invention also includes a three-dimensional structure consisting of such derived coordinates as the GPCRs of the invention.

In Table 1, atomic coordinates for the amino acid residues of individual helices and extra-cellular regions corresponds to amino acid residues 41-70 for HI, 78-107 for HII, 108-119 for ECI, 120-150 for HIII, 163-186 for HIV, 187-188 for ECII, 189-217 for HV, 239-270 for HVI, 271-281 for ECIII and 282-305 for HVII (residue numbers are entered in the 5th column).

II. Uses of the 3D Coordinates of MC4-R

For the first time, the present invention permits the use of virtual design techniques (i.e., computer modeling or “in silico”) to design, select, and synthesize a drug candidate capable of inhibiting/stimulating or binding MC4-R. In turn, these drug candidates may be effective in the treatment of a MC4-R mediated disorder.

The term “MC4-R mediated disorder” is disorder that involves a modulation in MC4-R activity in the biological manifestation of the disease, disorder, and/or condition; in the biological cascade leading to the disorder; or as a symptom of the disorder. This “involvement” of MC4-R in a MC4-R mediated disorder includes, but is not limited to, the following: (1) The modulation of MC4-R activity as a “cause” of the disorder or biological manifestation, whether the MC4-R is modulated genetically, by infection, by autoimmunity, trauma, biomechanical causes, lifestyle, or by some other causes. (2) The modulated MC4-R activity is part of the observable manifestation of the disease or disorder. That is, the disease or disorder is measurable in terms of the modulated MC4-R activity. From a clinical standpoint, modulated MC4-R activity indicates the disease, however, MC4-R activity need not be the “hallmark” of the disease or disorder. (3) The modulated MC4-R activity is part of the biochemical or cellular cascade that results in the disease or disorder. In this respect, inhibiting or stimulating of MC4-R (per the respective therapeutic goal) interrupts the cascade, and thus controls the disease. “Modulation in MC4-R activity,” as used herein, encompasses both unwanted or elevated MC4-R activity and desired or reduced MC4-R activity.

Non-limiting examples of MC4-R mediated disorders that may be treated by agonists or antagonists identified by the present invention include obesity, anorexia, inflammation, mental disorders, cachexia, metabolic and eating disorders, diabetes, insulin resistance, glucose intolerance, Type-2 diabetes mellitus, coronary artery disease, elevated blood pressure, hypertension, dyslipidaeniia, cancer (e.g., endometrial, cervical, ovarian, breast, prostate, gallbladder, colon), menstrual irregularities, hirsutism, infertility, gallbladder disease, restrictive lung disease, sleep apnea, gout, osteoarthritis, and thromboembolic disease, memory (including learning), cardiovascular function, sepsis, cardiogenic and hypovolemic shock, sexual dysfunction, penile erection, muscle atrophy, nerve growth and repair, intrauterine fetal growth, and the like.

In the present invention, it is possible to carry out virtual screening for drugs using the above-described atomic coordinates or derived coordinates therefrom.

Briefly, the atomic coordinates of the three-dimensional structure elucidated by the invention are input into a computer so that images of the structure and various parameters are shown on the display. All the information contained in Table 1 may be input, or atomic coordinates corresponding to at least one helix, or atomic coordinates corresponding to at least one extra-cellular region, or atomic coordinates corresponding to two helices linked by an extra-cellular region, or atomic coordinates corresponding to the top fifteen residues of at least one helix, or atomic coordinates corresponding to the top fifteen residues of two helices linked by an extra-cellular region may be input. For example, atomic coordinates corresponding to HI (41-70), HII (78-107), HIII (120-150), HIV (163-186), HV (189-217), HVI (239-270), HVII (282-305), ECI (108-119), ECII (187-188), ECIII (271-281), THII-ECI-THIII (93-134), THIV-ECII-THV (172-203), THVI-ECIII-THVII (256-296), THI (41-55), THII (93-107), THIII (120-134), THIV (172-186), THV (189-203), THVI (256-270), and/or THVII (282-296) may be input.

Then, the resultant data are input into a virtual compound library. Since a virtual compound library is contained in a virtual screening software such as DOCK-4 (Kuntz, UCSF), the above-described data may be input into such a software. Candidate drugs may be searched for using a three-dimensional structure database of virtual or non-virtual drug candidate compounds such as MDDR (Prous Science, Spain).

The potential stimulating/inhibitory or binding effect (i.e., interaction or association) of a drug candidate compound may be analyzed prior to its actual synthesis and testing by the use of computer modeling techniques. If the theoretical structure of the given compound suggests insufficient interaction and association between it and MC4-R, synthesis and testing of the candidate is obviated. However, if computer modeling indicates a strong interaction, the molecule may then be synthesized and tested for its ability to bind to or stimulate/inhibit MC4-R using various methods known in the art. Examples of such methods include the measurement of second messenger responses, in particular cAMP, such as the use of modified cell systems yielding color reaction upon accumulation of second messenger elements such as cAMP, e.g. as described by Chen et al. 1995 (Anal Biochem. 1995, 226, 349-54), Cytosensor Microphysiometer techniques (see Boyfield et al. 1996). In this manner, synthesis of inoperative candidates may be avoided.

Agonist/antagonist or binding drug candidates of MC4-R may be computationally evaluated and designed by means of a series of steps in which chemical entities or fragments are screened and selected for their ability to bind with the individual binding sites (e.g., HI, HV, HVI, HVII, ECI, ECII, ECIII) or other areas of MC4-R.

One skilled in the art may use one of several methods to screen chemical entities or fragments for their ability to associate with MC4-R and more particularly with the individual binding sites. This process may begin by visual inspection of, for example, the active site on the computer screen based on the MC4-R coordinates in Table I. Selected fragments or chemical entities may then be positioned in a variety of orientations, or docked, within an individual binding site of MC4-R as defined supra. Docking may be accomplished using software such as QUANTA, SYBYL, followed by energy minimization and molecular dynamics with standard molecular mechanics forcefields, such as CHARMM and AMBER.

Specialized computer programs may also assist in the process of selecting fragments or chemical entities. These include: (1) GRID (Goodford, P. J., “A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules” J. Med. Chem., 28, pp. 849-857 (1985)), available from Oxford University, Oxford, UK; (2) MCSS (Miranker, A. and M. Karplus, “Functionality Maps of Binding Sites: A Multiple Copy Simultaneous Search Method.” Proteins: Structure, Function and Genetics, 11, pp. 29-34 (1991)), available from Molecular Simulations, Burlington, Mass; (3) AUTODOCK (Goodsell, D. S. and A. J. Olsen, “Automated Docking of Substrates to Proteins by Simulated Annealing” Proteins: Structure. Function, and Genetics, 8, pp. 195-202 (1990)), available from Scripps Research Institute, La Jolla, Calif.; and (4) DOCK (Kuntz, I. D. et al., “A Geometric Approach to Macromolecule-Ligand Interactions” J. Mol. Biol., 161, pp. 269-288 (1982)), available from University of California, San Francisco, Calif; (5) GLIDE available from Schrodinger Inc.; (6) FlexX available from Tripos Inc; (7) GOLD (Jones et al., J. Mol. Biol., 245, 43-53, 1995) available from the Cambridge Crystallographic Data Centre.

Once suitable chemical entities or fragments have been selected, they can be assembled in silico or synthesized into a single drug candidate. In silico assembly may proceed by visual inspection of the relationship of the fragments to each other on the three-dimensional image displayed on a computer screen in relation to the structure coordinates of MC4-R. This would be followed by manual model building using software such as QUANTA or SYBYL. Chemical syntheses are by those methods well-known in the art.

Useful programs to aid one of skill in the art in connecting the individual chemical entities or fragments include the following: (1) CAVEAT (Bartlett, P. A. et al, “CAVEAT: A Program to Facilitate the Structure-Derived Design of Biologically Active Molecules”. In Molecular Recognition in Chemical and Biological Problems”, Special Pub., Royal Chem. Soc., 78, pp. 182-196 (1989)), available from the University of California, Berkeley, Calif.; (2) 3D Database systems such as MACCS-3D (MDL Information Systems, San Leandro, Calif.). This area is reviewed in Martin, Y. C., “3D Database Searching in Drug Design”, J. Med. Chem., 35, pp. 2145-2154 (1992)); and (3) HOOK (available from Molecular Simulations, Burlington, Mass.).

Instead of proceeding to build an MC4-R agonist or antagonist in a step-wise fashion one fragment or chemical entity at a time as described above, drug candidates useful for the treatment of MC4-R mediated disorders may be designed as a whole or “de novo” using either an empty active site or optionally including some portion(s) of a known agonist or antagonist. These methods include the following: (1) LUDI (Bohm, H.-J., “The Computer Program LUDI: A New Method for the De Novo Design of Enzyme Inhibitors”, J. ComR. Aid. Molec. Design, 6, pp. 61-78 (1992)), available from Biosym Technologies, San Diego, Calif.; (2) LEGEND (Nishibata, Y. and A. Itai, Tetrahedron, 47, p. 8985 (1991)), available from Molecular Simulations, Burlington, Mass.; (3) LeapFrog (available from Tripos Associates, St. Louis, Mo.). Examples of known agonist or antagonists are described in WO 02/26774 A2.

Once a drug candidate has been designed or selected by the above methods, the efficiency with which that candidate may bind to MC4-R may be tested and optimized by computational evaluation. An effective MC4-R agonist must preferably demonstrate a relatively small difference in energy between its bound and free states (i.e., a small deformation energy of binding). Thus, the most efficient MC4-R agonist should preferably be designed with a deformation energy of binding of not greater than about 10 kcal/mole, preferably, not greater than 7 kcal/mole. MC4-R agonists may interact with the enzyme in more than one conformation that is similar in overall binding energy. In those cases, the deformation energy of binding is taken to be the difference between the energy of the free compound and the average energy of the conformations observed when the agonist binds to the enzyme.

A compound designed or selected as binding to MC4-R may be further computationally optimized so that in its bound state it would preferably lack repulsive electrostatic interaction with the target enzyme. Such non-complementary (e.g., electrostatic) interactions include repulsive charge-charge, dipole-dipole and charge-dipole interactions. Specifically, the sum of all electrostatic interactions between the compound and the enzyme when the compound is bound to MC4-R, preferably make a neutral or favorable contribution to the enthalpy of binding.

Specific computer software is available in the art to evaluate compound deformation energy and electrostatic interaction. Examples of programs designed for such uses include: Gaussian 92, revision C [M. J. Frisch, Gaussian, Inc., Pittsburgh, Pa. ©1992]; AMBER, version 4.0 [P. A. Kollman, University of California at San Francisco, ©1994]; QUANTA/CHARMM [Molecular Simulations, Inc., Burlington, Mass. ©1994]; and Insight II/Discover (Biosysm Technologies Inc., San Diego, Calif. ©1994). Other software packages will be known to those skilled in the art.

Once a MC4-R-binding compound has been optimally selected or designed, as described above, substitutions may then be made in some of its atoms or side groups in order to improve or modify its binding properties. Generally, initial substitutions are conservative, i.e., the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original group. It should, of course, be understood that components known in the art to alter conformation should be avoided. Such substituted chemical compounds may then be analyzed for efficiency of fit to MC4-R by the same computer methods described in detail, above.

Except as otherwise noted, all amounts including quantities, percentages, portions, and proportions, are understood to be modified by the word “about”, and amounts are not intended to indicate significant digits.

Except as otherwise noted, the articles “a”, “an”, and “the” mean “one or more”.

All documents cited are, in relevant part, incorporated herein by reference; the citation of any document is not to be construed as an admission that it is prior art with respect to the present invention.

While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope.

Claims

1. A method of identifying a drug candidate useful for the treatment of a melanocortin receptors-4 (MC4-R) mediated disorder comprising the steps of: (a) using a three-dimensional (3D) structure of MC4-R according to Table 1; (b) employing said 3D structure to design or select in silico said drug candidate.

2. The method according to claim 1, further comprising the step of synthesizing said drug candidate.

3. The method according to claim 2, further comprising contacting said drug candidate in the presence of a substrate to test the ability of said candidate to modulate MC4-R.

4. The method according to claim 3, wherein said candidate is selected from a database of virtual or non-virtual compounds.

5. The method according to claim 3, wherein said candidate is designed de novo.

6. The method according to claim 3, wherein said candidate is designed from a known agonist or antagonist.

7. The method according to claim 1, wherein said step of employing said 3D structure to design or select said candidate comprises the steps of: (a) identifying in silico chemical entities or fragments capable of binding with a peptide selected from the group consisting of SEQ ID NOS: 2-11; and (b) assembling in silico or synthesizing the identified chemical entities or fragments in into a single molecule to provide the structure of said candidate.

8. The method according to claim 1, wherein said step of employing said 3D structure to design or select said candidate comprises the steps of: (a) identifying in silico chemical entities or fragments capable of binding with a peptide selected from the group consisting of SEQ ID NOS: 12-15; and (b) assembling in silico or synthesizing the identified chemical entities or fragments into a single molecule to provide the structure of said candidate.

9. The method according to claim 1, wherein said step of employing said 3D structure to design or select said candidate comprises the steps of: (a) identifying in silico chemical entities or fragments capable of binding with a peptide selected from the group consisting of SEQ ID NOS: 12, 16-21; and (b) assembling in silico or synthesizing the identified chemical entities or fragments into a single molecule to provide the structure of said candidate.

10. The method according to claim 1, wherein the candidate is an agonist or an antagonist of MC4-R.

11. A G-protein-coupled receptor selected from the group consisting of the following (a) or (b): (a) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates as shown in Table 1; (b) a G protein-coupled receptor having three-dimensional structure II defined by derived coordinates from the atomic coordinates as shown in Table 1, wherein the mean residual of the discrepancies between the positions of the α carbon atoms in the amino acid residues of seven helix sites SEQ ID NOS: 2-8 of the three-dimensional structure I and the positions of the corresponding α carbon atoms in the amino acid residues of the corresponding seven helix sites of the three-dimensional structure II is 1.5 Å or less when an image of the three-dimensional structure I obtained by computer-processing the atomic coordinates of Table 1 and an image of the three-dimensional structure II obtained by computer-processing said derived coordinates are superimposed.

12. The receptor of claim 11, wherein the G protein-coupled receptor is MC4-R.

13. The receptor of claim 11, wherein the G protein-coupled receptor is human MC4-R.

14. A method of identifying a drug candidate useful for the treatment of a melanocortin receptors-4 (MC4-R) mediated disorder comprising the steps of: (a) using a three-dimensional (3D) structure of a G-protein-coupled receptor selected from the group consisting of the following (i) or (ii): (i) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates as shown in Table 1; (ii) a G protein-coupled receptor having three-dimensional structure II defined by derived coordinates from the atomic coordinates as shown in Table 1, wherein the mean residual of the discrepancies between the positions of the α carbon atoms in the amino acid residues of seven helix sites SEQ ID NOS: 2-8 of the three-dimensional structure I and the positions of the corresponding α carbon atoms in the amino acid residues of the corresponding seven helix sites of the three-dimensional structure II is 1.5 Å or less when an image of the three-dimensional structure I obtained by computer-processing the atomic coordinates of Table 1 and an image of the three-dimensional structure II obtained by computer-processing said derived coordinates are superimposed. (b) employing said 3D structure to design or select said drug candidate.

15. The method according to claim 14, further comprising the step of synthesizing said drug candidate.

16. The method according to claim 15, further comprising contacting said drug candidate in the presence of a substrate to test the ability of said candidate to modulate MC4-R.

17. The method according to claim 16, wherein said candidate is selected from a database of virtual or non-virtual compounds.

18. The method according to claim 16, wherein said candidate is designed de novo.

19. The method according to claim 16, wherein said candidate is designed from a known agonist or antagonist.