Claims
- 1. A compound represented by the structural formula
- 2. A compound of claim 1 wherein n is zero.
- 3. A compound of claim 1 wherein the double dotted line represents a single bond.
- 4. A compound of claim 1 wherein R2, R8, R10 and R11 are each hydrogen, R3 is hydrogen, OH, C1-C6 alkoxy, —NHR18 or C1-C6 alkyl, and R34 is (H,H) or (H,OH).
- 5. A compound of claim 1 wherein R9 is H, OH or C1-C6 alkoxy.
- 6. A compound of claim 3 wherein X is —O—and Y is ═O.
- 7. A compound of claim 1 wherein R1 is C1-C6 alkyl.
- 8. A compound of claim 1 wherein B is —CH═CH—.
- 9. A compound of claim 1 wherein Het is pyridyl, W-substituted pyridyl, quinolyl or W-substituted quinolyl.
- 10. A compound of claim 9 wherein W is C1-C6 alkyl, R21-aryl or R41-heteroaryl.
- 11. A compound of claim 1 wherein R22 and R23 are independently selected from the group consisting of OH, (C1-C10)alkyl, (C2-C10)-alkenyl, (C2-C10)alkynyl, trifluoro(C1-C10)-alkyl, trifluoro(C2-C10)-alkenyl, trifluoro(C2-C10)alkynyl, (C3-C7)cycloalkyl, R25-aryl, R25-aryl(C1-C6)alkyl, R25-arylhydroxy(C1-C6)alkyl, R25-arylalkoxy(C1-C6)alkyl, (C3-C7)-cycloalkyl-(C1-C6)alkyl, (C1-C10)alkoxy, (C3-C7)cycloalkyloxy, (C1-C6)alkoxy(C1-C6)alkyl, OH—(C1-C6)alkyl, trifluoro(C1-C10)alkoxy and R27-heterocyclo-alkyl(C1-C6)alkyl.
- 12. A compound of claim 1 wherein R22 and R23 are independently selected from the group consisting of (C1-C10)alkyl and OH—(C1-C10)alkyl.
- 13. A compound of claim 1 wherein n is zero; the double dotted line represents a single bond; R2, R8, R10 and R11 are each hydrogen; R3 is hydrogen OH, C1-C6 alkoxy, —NHR18 or C1-C6 alkyl; R9 is H, OH or C1-C6 alkoxy; X is —O—; Y is ═O; R1 is C1-C6 alkyl; B is —CH═CH—; and Het is pyridyl, W-substituted pyridyl, quinolyl or W-substituted quinolyl.
- 14. A compound of claim 13 wherein R22 and R23 are independently selected from the group consisting of OH, (C1-C10)alkyl, (C2-C10)-alkenyl, (C2-C10)alkynyl, trifluoro(C1-C10)-alkyl, trifluoro(C2-C10)-alkenyl, trifluoro(C2-C10)alkynyl, (C3-C7)cycloalkyl, R25-aryl, R25-aryl(C1-C6)alkyl, R25-arylhydroxy(C1-C6)alkyl, R25-arylalkoxy(C1-C6)alkyl, (C3-C7)-cycloalkyl-(C1-C6)alkyl, (C1-C10)alkoxy, (C3-C7)cycloalkyloxy, (C1-C6)alkoxy(C1-C6)alkyl, OH—(C1-C6)alkyl, trifluoro(C1-C10)alkoxy and R27-heterocyclo-alkyl(C1-C6)alkyl.
- 15. A compound of claim 13 wherein R22 and R23 are independently selected from the group consisting of (C1-C10)alkyl and OH—(C1-C10)alkyl.
- 16. A compound of claim 13 wherein B is trans —CH═CH—.
- 17. A compound of claim 1 selected from the group consisting of compounds of the formula
- 18. A pharmaceutical composition comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 19. A method of inhibiting thrombin receptors comprising administering to a mammal in need of such treatment an effective amount of a compound of claim 1.
- 20. A method of inhibiting cannabinoid receptors comprising administering to a mammal in need of such treatment an effective amount of a compound of claim 1.
- 21. A method of treating thrombosis, platelet aggregation, coagulation, cancer, inflammatory diseases or respiratory diseases comprising administering to a mammal in need of such treatment an effective amount of a compound of claim 1.
- 22. A method of treating atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, myocardial infarction, glomerulonephritis, thrombotic stroke, thromboembolytic stroke, peripheral vascular diseases, cerebral ischemia, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, diabetes, osteoporosis, renal ischemia, cerebral stroke, cerebral ischemia, nephritis, inflammatory disorders of the lungs and gastrointestinal tract, reversible airway obstruction, chronic asthma or bronchitis comprising administering to a mammal in need of such treatment an effective amount of a compound of claim 1.
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Application Serial No. 60/211,724, filed Jun. 15, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60211724 |
Jun 2000 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09880222 |
Jun 2001 |
US |
Child |
10457256 |
Jun 2003 |
US |