Claims
- 1. A compound represented by the structural formula
- 2. A compound of claim 1 wherein the sum of n1 and n2 is 3.
- 3. A compound of claim 1 wherein R1, R10 and R11 are independently selected from the group consisting of H and C1-C6 alkyl; R2 and R8 are each hydrogen; and R9 is H, OH or C1-C6 alkoxy.
- 4. A compound of claim 1 wherein R is H, halogen, OH, C1-C6 alkyl, C1-C6 alkoxy or amino.
- 5. A compound of claim 1 wherein B is —CH═CH—.
- 6. A compound of claim 1 wherein Het is pyridyl, W-substituted pyridyl, quinolyl or W-substituted quinolyl.
- 7. A compound of claim 6 wherein W is —NR4R5, —NHCOR26, —NHSO2R16, R21-aryl or heteroaryl.
- 8. A compound of claim 7 wherein R21 is 1 to 3 substituents independently selected from the group consisting of H, —CF3, —OCF3, halogen, —CN, C1-C6 alkyl, C1-C6 alkoxy, —NH2 and —CR29(═NOR28).
- 9. A compound of claim 1 wherein R3 is H, hydroxy, C1-C6 alkoxy, halogen, C3-C6 cycloalkyl, —CN, (C1-C6)alkyl, —COOR17 or —NR4R5.
- 10. A compound of claim 1 wherein R22 is —COR23, —S(O)2R31 or —COOR27.
- 11. A compound of claim 10 wherein R23 is C3-C7-cycloalkyl; (C3-C7)cycloalkyl substituted by 1 to 3 substituents selected from the group consisting of halo, (C1-C3)alkoxy(C1-C3)alkyl, hydroxy and C1-C6 alkoxy; (C3-C7)cycloalkyl(C1-C6)alkyl; aryl; or aryl(C2-C6)alkyl.
- 12. A compound of claim 11 wherein R23 is C3-C7-cycloalkyl; (C3-C7)cycloalkyl(C1-C6)alkyl or aryl-(C2-C6)alkyl.
- 13. A compound of claim 10 wherein R31 is (C1-C6)alkyl, C3-C7-cycloalkyl, aryl or aryl(C1-C6)alkyl.
- 14. A compound of claim 10 wherein R27 is C1-C6alkyl, phenyl, benzyl, (C1-C3)alkoxy(C1-C3)alkyl or (C3-C7)cycloalkyl.
- 15. A compound of claim 1 selected from the group consisting of compounds of the formula
- 16. A pharmaceutical composition comprising an effective amount of at least one compound of claim 1 and a pharmaceutically acceptable carrier.
- 17. A method of inhibiting thrombin receptors comprising administering to a mammal in need of such treatment an effective amount of at least one compound of claim 1.
- 18. A method of treating thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, myocardial infarction, glomerulonephritis, thrombotic stroke, thromboembolytic stroke, peripheral vascular diseases, inflammatory diseases, respiratory diseases, cerebral ischemia or cancer, comprising administering to a mammal in need of such treatment an effective amount of at least one compound of claim 1.
- 19. A compound selected from the group consisting of compounds of the formula
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Application No. 60/330,359, filed Oct. 18, 2001.
Provisional Applications (1)
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Number |
Date |
Country |
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60330359 |
Oct 2001 |
US |