Time Independent Viscoelastic Analysis Parameter for Prediction of Patient Outcome

BACKGROUND OF THE INVENTION

The present invention relates to the fields of medicine and surgery, and emergent and chronic critical care for traumatic injury.

Following a traumatic injury (e.g., gunshot wound, car accident, or during surgery), uncontrolled hemorrhage (i.e., uncontrolled bleeding) is a leading cause of early death (Eastridge et al., J. of Trauma. 71(1 Suppl): S4-8, 2011; Gonzalez et al., J. of Trauma. 62(1):112-9, 2007; Kashuk et al., J. of Trauma 65(2):261-71, 2008). Trauma induced coagulopathy (TIC) is an exacerbating phenomenon observed in many cases of massive hemorrhage, and current practice emphasizes hemostatic resuscitation with blood components (Brohi et al., Current Opinion in Critical Care 13(6): 680-685, 2007; Brohi et al., Annals of Surgery 245(5): 812-818, 2007; Brohi et al., J. of Trauma, 64(5): 1211-1217, 2008; Cohen et al., Annals of Surgery 255(2): 379-385, 2012; Cotton et al., J. of Trauma and Acute Care Surgery 73(2):365-70, 2012; Dunn et al., Surg. Forum. 30:471-3, 1979). This practice is geared at not only replacing lost oxygen carrying capacity, but in reestablishing normal coagulation and forestalling the “bloody vicious cycle” of hemorrhagic shock, acidosis/hypothermia and coagulopathy (Kashuk et al., J. of Trauma 22(8):672-9, 1982; Cohen et al., Surg. Clin North Am. 92(4):877-91, 2012). Establishment, by hospital blood banks, of massive transfusion protocols (MTPs) to aid in efficient hemostatic resuscitation of patients with life-threatening hemorrhage, represents an important development in trauma systems management and has been shown to reduce mortality in massively bleeding patients.

Triggering a massive transfusion protocol (MTP) activation, however, is not without potentially negative consequences. Transfusion of blood or blood broducts consume large amounts of scarce medical resources (e.g. universal donor blood components either transfused or wasted) as well as exposing patients to the risks of transfusion of multiple units of blood products, empirically and potentially needlessly unless patients who truly require an MTP activation are chosen accurately (Johnson et al., Archives of Surgery 145(10):973-7, 2010; Moore et al., Archives of Surgery 132(6):620-4, 1997; Watson et al., J. of Trauma. 2009 August; 67(2):221-7; discussion 8-30, 2009; Neal et al., Archives of Surgery. 147(6):563-71, 2012).

Thus, there is a need to distinguish patients in massive hemorrhage who truly need a transfusion protocol from those patients who do not.

Viscoelastic analysis methods such as thrombelastography (TEG) and thromboelastometry (TEG) are robust and versatile diagnostic systems for point-of-care diagnosis of coagulopathy. However, application of these analysis methods in high acuity settings such as trauma and emergency surgery has been limited by the time it takes the test to yield a result with regard to clot strength, a key parameter for interpretation of the overall clotting performance of the patient's blood.

It would be useful to have rapid methods and parameters to accurately predict final clot strength and/or identify those patients who need transfusion of blood or blood products.

SUMMARY OF THE EMBODIMENTS

The invention provides new parameters from viscoelastic analyses of blood that are not dependent upon time.

In a first aspect, the invention provides an in vitro method for identifying a patient as likely to require a transfusion of at least six units of blood in six hours or less, the method comprising, consisting essentially of, or consisting of obtaining a coagulation characteristic value that is independent of time by using a viscoelastic analysis assay to analyze a sample of blood from the patient, wherein the coagulation characteristic value of the patient that is lower than a coagulation characteristic value that is independent of time of a control (such as a healthy volunteer) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time of a control is obtained by analyzing a sample of blood from the control with a viscoelastic analysis assay. In some embodiments, the the control is a healthy volunteer. In some embodiments, the control is a population of patients and the coagulation characteristic value of the control is the mean coagulation characteristic value of the population.

In some embodiments, the sample of blood is not supplemented with a clotting factor or an enhancer of clot formation. In some embodiments, the coagulation characteristic value that is independent of time is Acrit. In some embodiments, the coagulation characteristic value that is independent of time is dAmax.

In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than twenty minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value is obtained not more than fifteen minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than ten minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than ten minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value is obtained not more than five minutes after the start of clot formation in the sample of blood from the patient.

In some embodiments, the patient is human. In some embodiments, the patient is a trauma patient.

In some embodiments, the viscoelastic analysis assay is performed using a thromboelastography analyzer system. In some embodiments, the viscoelastic analysis assay is performed using a thromboelastometry analyzer system.

In some embodiments, the coagulation characteristic value that is independent of time of the patient that is at least 1.5 times lower than the coagulation characteristic value that is independent of time of the control (e.g., a healthy volunteer or a population of patients) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less. In some embodiments, the coagulation characteristic value of the patient that is at least 1.5 times lower than the coagulation characteristic value of the control (e.g., a healthy volunteer or a population of patients) identifies the patient as likely to require a transfusion of at least ten units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time is obtained by fitting a tracing from the viscoelastic analysis assay of the same sample of blood from the patient to a tracing from the model dA/dT=aA²/(e^bA−1). In some embodiments, the coagulation characteristic value that is independent of time is obtained by taking an area under a tracing from the viscoelastic analysis assay of the same sample of blood from the patient from a start of clot formation to a maximum amplitude.

In another aspect, the invention provides an in vitro method for identifying a patient as likely as likely to require a transfusion of at least six units of blood in six hours or less, the method comprising, consisting essentially of, or consisting of (a) analyzing a sample of blood from a patient with a viscoelastic analysis assay to obtain a coagulation characteristic value that is independent of time of the patient; and (b) comparing the coagulation characteristic value of the patient to the coagulation characteristic value of the control, wherein the coagulation characteristic value of the patient that is lower than the coagulation characteristic value of the control (e.g., a healthy volunteer) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than ten minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than five minutes after the start of clot formation in the sample of blood from the patient.

In some embodiments, the patient is human. In some embodiments, the patient is a trauma patient.

In yet another aspect, the invention provides an in vitro method for determining an amount of fibrinogen in a patient comprising: (a) obtaining a coagulation characteristic value that is independent of time of a sample of blood from the patient using a viscoelastic analysis assay and (b) plotting the patient coagulation characteristic value against a standard table of coagulation characteristic values of blood samples of healthy volunteers with known amounts of fibrinogen to determine the amount of fibrinogen in the sample of blood from the patient.

In some embodiments, the coagulation characteristic value that is independent of time is dAmax. In some embodiments, the patient is human.

In still another aspect, the invention provides an in vitro method for determining a quantity of platelets in a patient comprising: (a) obtaining a coagulation characteristic value that is independent of time of a sample of blood from the patient using a viscoelastic analysis assay and (b) plotting the patient coagulation characteristic value against a standard table of coagulation characteristic values of blood samples of healthy volunteers with known quantities of platelets to determine the quantity of platelets in the sample of blood from the patient.

In some embodiments, the coagulation characteristic value is a product of dAmax and Acrit. In some embodiments, the patient is human.

BRIEF DESCRIPTION OF THE DRAWINGS

The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee

The foregoing features of embodiments will be more readily understood by reference to the following detailed description, taken with reference to the accompanying drawings, in which:

FIG. 1 is a schematic diagram showing the clotting cascade that leads eventually to the formation of a blood clot. The contributions of the intrinsic and extrinsic pathway to the blood clot are shown.

FIG. 2A is a schematic diagram showing a thromboelastography (TEG) tracing or curve. As the upper and lower portions of the tracing are mirror images of each other, TEG tracings are sometimes depicted as just the upper half of the tracing. The time from assay initiation is the dependent variable (on the x-axis) and the amplitude of coupling of the motion of the reaction cup to a centrally suspended pin (a proxy for viscoelastic clot strength) is the readout variable, on the y-axis, as reported in FIG. 1A in units of millimeters. The events leading up to maximum amplitude (MA) of the clot are the clot formation stage, and following the MA is the clot dissolution stage or fibrinolysis stage.

FIG. 2B is a schematic diagram showing a TEG tracing from a healthy human volunteer. Note that in a healthy volunteer, fibrinolysis is very gradual.

FIG. 3 is a schematic diagram showing a thromboelastometry (TEM) tracing or curve. As the upper and lower portions of the tracing are mirror images of each other, TEM tracings are sometimes depicted as just the upper half of the tracing. The events leading up to maximum clot firmness (MCF) of the clot are the clot formation stage (or coagulation stage), and following the MA is the clot dissolution stage or fibrinolysis stage.

FIG. 4 is a schematic drawing showing a side-by-side comparison of a TEG tracing (top half of figure) and a TEM tracing (bottom half of figure). As is clear from FIG. 4, the R value in a TEG tracing is equivalent to a clotting time (CT) value in a TEM tracing, the K value in a TEG tracing is equivalent to a clot formation time (CFT) value in a TEM tracing, the MA value in a TEG tracing is equivalent to a MCF value in a TEM tracing.

FIGS. 5A and 5B are two TEM tracings. FIG. 5A is a TEM tracing in the presence of the EXTEM reagent, which allows assessment of clot formation, fibrin polymerization, and fibrinolysis via the extrinsic pathway. FIG. 5B is a TEM tracing the presence of the FIBTEM reagent, which blocks platelets. Thus, FIG. 5B shows an assessment of the clot firmness of a fibrin clot. As FIGS. 5A and 5B show, platelet and fibrinogen contribution to clot strength are not additive.

FIG. 5C is a schematic diagram showing a TEG tracing from a functional fibrinogen assay (green line) compared to the TEG tracing from a functional fibrinogen assay for a sample treated with tranexamic acid (TXA), an antifibrinolytic agent that blocks the action of plasminogen (blue line). As can be seen, in the presence of hyperfibrinolysis (as simulated by the addition of TXA) may obscure and lower the MA, as depicted in red parallel bars in FIG. 5C by the difference between the peaks of the green line and the blue line.

FIGS. 6A-6C is are variations of TEG tracings from a healthy human volunteer. FIG. 6A shows the classic TEG tracing. Note that this tracing in FIG. 6A is the upper half of the full TEG tracing, with amplitude (in mm) on the Y axis and time (in minutes) on the X axis. The point at which the amplitude is increasing most rapidly is depicted as the Acrit parameter. In FIG. 6A, the Acrit occurs when A (the amplitude) is 11.64. The derivative of this new parameter Acrit, namely dA, is 0.68. FIG. 6B is a curve showing the dA (derivative of amplitude) on the Y axis plotted against amplitude (in mm) on the Y axis. FIG. 6C shows the position of Acrit on the tracings of FIG. 6A and FIG. 6B. Thus, FIG. 6C shows that the Acrit parameter is when dA is 0.68 mm and A is 11.74 mm.

FIG. 6A is a TEG tracing from a healthy human volunteer (namely, patient no. 20074B). FIG. 6A shows the Acrit (with a dA at 0.66 and an A (amplitude) at 13.65 mm) which occurs at approximately 17.0 minutes. Additionally, FIG. 7A shows the split time (at t (time)=13.166667 minutes), A5 (at t=18.17 min and A=20.82 mm), A10 (at 5=23.17 min and A=43.18 mm, and Amax (i.e., the MA) at A=59.02 mm). In the patient shown in FIG. 7A, Amax occurs at approximately 42 minutes.

FIG. 7B is a line graph plotting dA/dT against amplitude for dA/dT=aA²/(e^bA−1) with coefficient a=0.011 and coefficient b=0.104 when A goes from 0 to 60.

FIG. 7C is a line graph plotting dA/dT against amplitude for dA/dT=aA²/(e^bA−1) with coefficient a=0.022 and coefficient b=0.104 when A goes from 0 to 60.

FIG. 7D is a line graph plotting dA/dT against amplitude for dA/dT=aA²/(e^bA−1) with coefficient a=0.011 and coefficient b=0.208 when A goes from 0 to 60.

FIG. 7E is a customized model line graph showing the a and b coefficients of patient 20074B (patient data shown as red squares) to create a custom model fitting the patient dA/dT data points against amplitude.

FIG. 8 is a dot plot, showing the dAmax plotted as a function of Acrit. The populations shown are healthy volunteers (light green triangles), trauma patients with negative significant hemorrhage (dark green squares), and trauma patients with massive hemorrhage (needing 10 units of blood in 6 hours, or dying of exsanguination in 6 hours) (orange diamonds).

FIG. 9 is a dot plot, showing the dAmax plotted as a function of Acrit. The populations shown are healthy volunteers (light green triangles), trauma patients with negative significant hemorrhage (dark green squares), trauma patients with significant hemorrhage (needing 6-10 units of blood in 6 hours) (yellow circles), and trauma patients with massive hemorrhage (needing 10 units of blood in 6 hours, or dying of exsanguination in 6 hours) (orange diamonds).

FIG. 10 is a histogram showing the area under the model curve at infinity. The area under the curve (AUC) from the split to the critical amplitude (i.e., the highest dA) is 5.39. Thus, the time-independent TEG AUC (TITAUC) is calculated in the amplitude domain and measures catalysis in the “launch phase” of clotting.

FIG. 11 is a line graph plotting the percent sensitivity versus the percent specificity for the receiver operating characteristic curve (ROC) of the time-independent TEG area under the curve (TITAUC) for patients with significant hemorrhage (i.e., trauma patients who need between 6 to 10 units of blood in 6 hours). As that data shows, quantitation of early catalysis predict those patients with significant hemorrhage.

FIG. 12 is a line graph plotting the percent sensitivity versus the percent specificity for the receiver operating characteristic curve (ROC) of the time-independent TEG area under the curve (TITAUC) for patients with massive hemorrhage (i.e., trauma patients who need at least 10 units of blood in 6 hours or less, or bleed to death within 6 hours). As that data shows, quantitation of early catalysis predict those patients with massive hemorrhage.

FIG. 13 is the tracing of the derivative of the amplitude of FIG. 7A fitted to the Amax curve (green line) and the Acrit curve (red line). As can be seen, with these two parameters, the fit is extremely close.

FIG. 14 is a scatter plot showing the convergence of the fit with increasing data, plotting time offset from Acrit (min) on the x-axis and normalize difference between model and empirical area (mm²) on the y-axis.

FIG. 15 is a fitting of the data to the model, even when the fit is only to Acrit. This yields the very simple prediction that MA is approximately equal to 15 (ln Q)+12 mm.

FIG. 16 is a scatter plot demonstrating sigmoid relation of dAmax to the amount of fibrinogen is a blood sample.

FIG. 17 is a scatter plot showing that a product of dAmax multiplied by Acrit (the “critical product”) is correlates linearly with the number of platelets in a blood sample.

FIG. 18 is a line graph showing receiver operating characteristic curve (ROC) of the time-independent TEG area under the curve (TITAUC) for patients with massive hemorrhage as compared to conventional TEG parameters. As can be see, the area under the curve (AUC) for time-independent TEG (blue line) has a higher identity for predicting massive hemorrhage than the AUC for MA (red line), the AUC for the alpha angle (purple line), the AUC for activated clotting time (ACT) (brown line) and the AUC for the International Normalization Ratio (INR) (green line).

DETAILED DESCRIPTION OF SPECIFIC EMBODIMENTS

The invention stems, in part, from the discovery of very rapid in vitro methods to reliably and accurately identify patients who are likely need a blood transfusion. The publications (including patent publications), web sites, company names, and scientific literature referred to herein establish the knowledge that is available to those with skill in the art and are hereby incorporated by reference in their entirety to the same extent as if each was specifically and individually indicated to be incorporated by reference. Any conflict between any reference cited herein and the specific teachings of this specification shall be resolved in favor of the latter.

The further aspects, advantages, and embodiments of the invention are described in more detail below. The definitions used in this specification and the accompanying claims shall following terms shall have the meanings indicated, unless the context clearly otherwise requires. Any conflict between an art-understood definition of a word or phrase and a definition of the word or phrase as specifically taught in this specification shall be resolved in favor of the latter. As used in this specification, the singular forms “a,” “an” and “the” specifically also encompass the plural forms of the terms to which they refer, unless the content clearly dictates otherwise. The term “about” is used herein to mean approximately, in the region of, roughly, or around. When the term “about” is used in conjunction with a numerical range, it modifies that range by extending the boundaries above and below the numerical values set forth. In general, the term “about” is used herein to modify a numerical value above and below the stated value by a variance of 20%.

Haemostasis is a tightly regulated process which causes bleeding to stop. In the body, circulating blood remains fluid under normal conditions, but forms localized clots when the integrity of the vascular system is breeched. Trauma, infection, and inflammation all activate the blood's clotting system, which depends on the interaction of two separate systems: enzymatic proteins in a clotting cascade (e.g., clotting factors such as Factor VII or Factor IX) and activated platelets. The two systems work in concert to plug defects in the broken vessels.

A blood clot (also called a thrombus) that forms during haemostasis is made of two parts—a platelet plug and a mesh of cross-linked fibrin protein. The fibrin results from cleavage of fibrinogen into fibrin by thrombin which is activated during the clotting cascade (see FIG. 1). A blood clot needs to be of sufficient strength to resist dislodgement by circulating blood or mechanical movement. If a particular clotting factor is dysfunctional or absent, as in hemophilia, an insufficient amount of fibrin forms. Similarly, massive consumption of clotting factors in a trauma situation decreases the amount of fibrin formed and can lead to uncontrolled hemorrhage. Inadequate numbers of platelets resulting from trauma, surgery, or chemotherapy also decrease platelet aggregation, as do genetic disorders, uremia, or salicylate therapy. Ultimately, reduced fibrin formation or platelet aggregation results in clots of inadequate tensile strength. This hypocoagulable state makes the patient prone to bleeding. Conversely, endothelial injury, stasis, cancer, genetic diseases, or other hypercoagulable states lead to thrombosis (i.e., blood clot) formation, exemplified in deep-vein thromboses, pulmonary emboli, and arterial occlusions such as stroke and myocardial infarction.

When a trauma patient is brought into a treatment center such as an emergency room, uncontrolled hemorrhage can lead to death. However, a recent analysis of data from a three year study of resuscitation strategies of patients (whose inclusion criteria included activation of an MTP) revealed that only 46% of patients, for whom an MTP was activated based upon the judgment of the attending trauma surgeon, actually went on to require a massive transfusion (defined as ≥10 units or packed red blood cells [PRBCs] in 6 hours). It is clear that clinician judgment leaves much to be desired in terms of accuracy of prediction of massive transfusion requirement. Additionally, recent experience with the design of several prospective trials related to trauma resuscitation have highlighted the difficulty in early, prospective selection of patients truly at high risk of major hemorrhage and coagulopathy (Brasel et al., Journal of the American College of Surgeons. 2008 February; 206(2):220-32, 2008; Bulger et al., Archives of surgery. 2008 February; 143(2):139-48; discussion 49); Bulger et al., Annals of surgery. 2011 March; 253(3):431-41; and Raab et al., Critical care medicine. 2008 November; 36(11 Suppl): S474-80).

Given the scarcity of donor blood (and blood products) and the potential risks associated from receiving a donor blood product (e.g., recipient immune response to the donor blood or recipient exposure to pathogens or contaminants in the donor blood), attempts have been made to develop new parameters, or repurpose existing parameters, in order to rapidly and accurately predict which patients are in need of a blood transfusion (e.g., with blood or a blood product). Such patients can be identified, for example, by determining clot strength of a blood sample taken from the patient.

Thus, in some embodiments, the invention provides in vitro methods for identifying a patient likely to suffer a massive hemorrhage (i.e., those patients who will require a transfusion of at least 10 units of blood in 6 hours or less, or who will bleed to death). In some embodiemtns, the method comprises obtaining a coagulation characteristic value that is independent of time using a viscoelastic analysis assay to analyze a sample of blood taken from the patient, wherein the coagulation characteristic value of the patient that is lower than a specified threshold (e.g., to some degree lower than that of a healthy volunteer or lower than the mean coagulation characteristic value of a population of patients) predicts that the patient is likely to suffer a massive hemorrhage. Early prediction of massive hemorrhage can be lifesaving as it allows the clinician to initiate massive transfusion protocol or other resuscitative interventions in a timely manner.

In some embodiments, the methodology described herein can be used to rapidly discriminate the origin of the coagulopathy leading to the massive hemorrhage as being with a defect in platelet or fibrinogen function.

The invention stems, in part, from the identification of a coagulation characteristic value derived from data obtained from analyzing patient blood samples using viscoelastic analyses. Such viscoelastic analyses include, without limitation, thromboelastography (TEG) and thromboelastometry (TEM).

As used herein, by “blood sample” or “sample of blood” is meant a sample of blood taken, for example, from a patient. The patient may be a human, but may also be any other animal (e.g., veterinary animal or exotic animal). Blood is the circulating tissue of an organism that carries oxygen and nutritive materials to the tissues and removes carbon dioxide and various metabolic products for excretion. Blood (often called whole blood) consists of a pale yellow or gray yellow fluid, plasma, in which are suspended red blood cells, white blood cells, and platelets. Some practitioners consider blood to be an organ. However, all agree that how quickly blood will clot is discernible from a sample of blood. It is a matter of analyzing the sample correctly to determine how the blood (e.g., cells and proteins in the blood) will clot. While current technology is limited by how quickly such information can be deduced from a sample of blood, in some embodiments, the present invention allows for such information to be obtained very quickly.

In some embodiments, as the term is used herein, by “blood” is meant whole blood, or a portion of whole blood, or a blood product (e.g., packed red blood cells). The blood in the blood sample taken from a patient (e.g., a trauma patient or a healthy volunteer) may thus be a sample of whole blood or a sample of a portion of blood or a sample of a blood product. The blood (e.g., blood in a blood sample) may be untreated, or may be treated. For example, a blood sample may be citrated blood (e.g., whole blood collected into a 3.5 mL container containing 3.2% citrate). The blood (e.g., blood in a blood sample) may also be a sample of platelet rich plasma. The blood (e.g., blood in a blood sample) may also be heparinized blood or may be a blood sample treated with protamine to reverse the effects of heparin. In some embodiments, the blood sample is not supplemented with a clotting factor (e.g., thrombin) and/or is not supplemented with an enhancer of clot formation (e.g., kaolin). The blood (e.g., blood in a blood sample) may be fresh, frozen, or stored according to standard methods (e.g., stored at 4° C. in a blood storage solution such as the storage solution described in U.S. Pat. No. 8,709,707). Thus, whenblood refers to one or more components of whole blood, any of these components may be treated. Thus, blood (e.g., blood in a blood sample) may be platelets, packed red blood cells, heparinized packed red blood cells, citrated blood, plasma or platelet-free plasma taken from the blood of the patient. In some embodiments, the blood (e.g., blood in a blood sample) may be a sample that has reduced platelet function. For example, the blood (e.g., blood in a blood sample) may be treated with an inhibitor of platelet function such as cytochalasin D.

Note that by “blood transfusion” or simply “transfusion” is meant administration (e.g., by intravenous route) of blood (as defined above) to a recipient patient. The blood transfused to the patient can be fresh, or frozen, and can be whole blood, citrated blood, packed red blood cells, platelets, and so forth. Typically, blood is administered in units, where one unit of blood is roughly equal to one pint of whole blood. Note that the unit of blood may be a unit of packed red blood cells, but that unit of packed red blood cells is still equivalent to approximately one pint of whole blood for the donor. In some embodiments, the transfusion given to the patient is matched to the patient's ABO profile (e.g., O type blood donated to A patient, B patient, or AB patient, or B type blood donated to B or AB patient).

By “viscoelastic analysis” or “viscoelastic analysis assay” is meant any in vitro analysis method that measures the characteristics of elastic solid (e.g., fibrin solids) and fluids. In other words, viscoelastic analysis allows the study of properties of a viscous fluid, such as blood or a blood sample taken from a patient (e.g., a human patient). By using viscoelastic analysis, the mechanical strength of an evolving blood clot can be measured in vitro.

In some embodiments, the viscoelastic analysis is performed under conditions that mimic the conditions in vivo that govern hemostasis. Hemostasis is a tightly regulated, extremely complex process involving many interacting factors, which include coagulation and fibrinolytic proteins, activators, inhibitors and cellular elements, such as platelet cytoskeleton, platelet cytoplasmic granules and platelet cell surfaces, that controls bleeding in the body of an individual (e.g., a human individual). Hemostasis includes and comprises the balance between two processes: (1) the coagulation process, namely blood coagulation by formation of a fibrin-containing blood clot, and (2) the fibrinolysis process, namely the process involved in the breakdown of that clot, for example, by activation of plasmin to dissolve the fibrin mesh holding the clot together.

For example, the condition may include a temperature that mimics a body temperature (e.g., a temperature of 37° C.). The condition may also include clot formation and dissolution at flow rates that mimic those found in blood vessels.

Various devices that perform thromboelastography, and methods for using these devices, are described in U.S. Pat. Nos. 5,223,227; 6,225,126; 6,537,819; 7,182,913; 6,613,573; 6,787,363; 7,179,652; 7,732,213, 8,008,086; 7,754,489; 7,939,329; 8,076,144; 6,797,419; 6,890,299; 7,524,670; 7,811,792; 20070092405; 20070059840; U.S. Pat. No. 8,421,458; US 20120301967; and U.S. Pat. No. 7,261,861, the entire disclosures of each of which are hereby expressly incorporated herein by reference.

Thromboelastography (TE) monitors the elastic properties of blood as it is induced to clot under a low shear environment resembling sluggish venous blood flow. The patterns of changes in shear elasticity of the developing clot enable the determination of the kinetics of clot formation, as well as the strength and stability of the formed clot; in short, the mechanical properties of the developing clot. As described above, the kinetics, strength and stability of the clot provides information about the ability of the clot to perform “mechanical work,” i.e., resisting the deforming shear stress of the circulating blood. In essence, the clot is the elementary machine of hemostasis. Hemostasis instruments that measure hemostasis are able to measure the ability of the clot to perform mechanical work throughout its structural development. These hemostasis analyzers measure continuously all phases of patient hemostasis as a net product of whole blood components in a non-isolated, or static fashion from the time of test initiation until initial fibrin formation, through clot rate strengthening and ultimately clot strength through clot lysis.

In some embodiments, the viscoelastic analysis and/or the hemostais analyzer comprises a container which is in contact with the blood.

As used herein, by “container” is meant a rigid surface (e.g., a solid surface), a portion of which contacts a portion of a blood sample placed into the container at any point during the viscoelastic analysis. The portion of the container that contact the portion of blood sample may also be referred to as the “interior” of the container. Note that the phase “into the container” does not mean that the container has a bottom surface which is in contact with the portion of the blood sample. Rather, the container can be a ring-shaped structure, where the inside of the ring is the interior of the container, meaning that the inside of the ring is the portion of the ring-shaped container that contacts a portion of the blood sample. A blood sample can flow into the container and be held there, for example, by vacuum pressure or surface tension.

Still additional types of containers that are included in this definition are those present on plates and cassettes (e.g., a microfluidic cassette), where the plate or cassette has multiple channels, reservoirs, tunnels, and rings therein. Each of the contiguous channels (comprising, for example, a channel, a reservoir, and a ring) is a container, as the term is used herein. Hence, there may be multiple containers on one cassette. U.S. Pat. No. 7,261,861 (incorporated herein by reference) describes such a cassette with multiple channels or containers. Any of the surfaces in any of the channels or tunnels of the cassette may be an interior of the container if that surface comes into contact with any portion of the blood sample, at any time during the viscoelastic analysis.

Additional non-limiting hemostasis analyzer instruments are described in U.S. Pat. No. 7,261,861; US Patent Publication No. US20070092405; and US Patent Publication No. US20070059840.

A non-limiting analyzer instrument that performs viscoelastic analysis using thromboelastography is the TEG thromboelastograph hemostasis analyzer system sold commercially by Haemonetics, Corp. (Braintree, Mass.).

Thus, the TEG assay may be performed using the TEG thromboelastograph hemostasis analyzer system that measures the mechanical strength of an evolving blood cloth. To run the assay, the blood sample is placed into a container (e.g., a cup or a cuvette), and a metal pin goes into the center of the container. Contact with the interior walls of the container (or addition of a clot activator to the container) initiates clot formation. The TEG thromboelastograph hemostasis analyzer then rotates the container in an oscillating fashion, approximately 4.45 degrees to 4.75 degrees, every 10 seconds, to imitate sluggish venous flow and activate coagulation. As fibrin and platelet aggregates form, they connect the inside of the container with the metal pin, transferring the energy used to move the container in the pin. A torsion wire connected to the pin measures the strength of the clot over time, with the magnitude of the output directly proportional to the strength of the clot. As the strength of the clot increases over time, a classic TEG tracing curve develops (See FIG. 2A, where clot strength is reflected on the Y axis and time is on the X axis).

Where there is a pin in the TEG analyzer, the rotational movement of the pin is converted by a transducer to an electrical signal, which can be monitored by a computer including a processor and a control program. The computer is operable on the electrical signal to create a hemostasis profile corresponding to the measured clotting process. Additionally, the computer may include a visual display or be coupled to a printer to provide a visual representation of the hemostasis profile. Such a configuration of the computer is well within the skills of one having ordinary skill in the art. As shown in FIG. 2A, the resulting hemostasis profile (i.e., a TEG tracing curve) is a measure of the time it takes for the first fibrin strand to be formed, the kinetics of clot formation, the strength of the clot (measured in millimeters (mm) and converted to shear elasticity units of dyn/cm 2) and dissolution of clot. See also Donahue et al., J. Veterinary Emergency and Critical Care:15(1): 9-16. (March 2005), herein incorporated by reference

The descriptions for several of these measured parameters shown in FIG. 2A are well known and have been described elsewhere (see, e.g., Kouerinis et al., Interactive Cardiovascular and Thoracic Surgery 7: 560-563, 2008; Walsh et al., J. of Extracorporeal Tech. 43(3): 162-167, 2011; and Galvez and Cortes, Revista Colombiana Anestesiol. 40: 224-230, 2012; all incorporated by reference herein in their entireties).

Briefly, ACT (or R) is the time is the period of time of latency from the time that the blood sample is placed in the TEG analyzer until the initial clot formation. This is typically takes about 4-8 minutes in a healthy person. For patients in a hypocoagulable state (i.e., a state of decreased coagulability of blood), the ACT (or R) number is longer (i.e., higher), while in a hypercoagulable state (i.e., a state of increased coagulability of blood), the ACT (or R) number is shorter.

K value (measured in minutes) is the time from the end of ACT until the clot reaches 20 mm. The K value represents the speed of clot formation. This K value is about 0 to about 4 minutes (i.e., after the end of ACT) in a healthy person. In a hypocoagulable state, the K number is longer, while in a hypercoagulable state, the K number is shorter.

α measures the rapidity of fibrin build-up and cross-linking (clot strengthening). Thus, it shows the rate at which a solid clot is formed. It is angle between the line formed from the split point tangent to the curve and the horizontal axis, and represents the kinetics of clot development. This angle is typically about 47° to 74°. In a hypocoagulable state, the a degree is lower, while in a hypercoagulable state, the α degree is higher.

MA or Maximum Amplitude in mm, is a direct function of the maximum dynamic properties of fibrin and platelet bonding and represents the ultimate or maximum strength of the clot. The MA number (also referred to herein as Amax) is the greatest diameter of the clot and a measure of the clot's elasticity. This number is typically from about 54 mm to about 72 mm in a normal individual, and the MA occurs typically between about 15 to about 35 minutes after the start of the viscoelastic assay. Note that if the blood sample tested has a reduced platelet function, this MA represents the strength of the clot based on fibrin only. Decreases in MA may reflect a hypocoagulable state (e.g., with platelet dysfunction or thrombocytopenia), whereas an increased MA (e.g., coupled with decreased R) may be suggestive of a hypercoagulable state.

LY30 measures the rate of amplitude reduction 30 minutes after MA and represents clot retraction, or lysis. The LY30 is, therefore, the percentage of lysis of the clot or a percentage decrease in amplitude 30 minutes after the MA. The LY30 can also be described as the loss of potential area of under the TEG curve. For example, if the amplitude of the curve did not decrease following the peak at MA, the LY30 would be 0%. In healthy individuals, this LY30 number is typically 0% to about 8% (see FIG. 2B). In some embodiments, a hypocoagulable state is present if the LY30 is greater than 7.5%. In some embodiments, an LY30 that is greater than 6%, or greater than about 5%, or greater than about 4%, or greater than about 3.5%, or greater than about 3% identifies a patient with a hypocoagulable state.

Another viscoelastic hemostasis assay that can be used is the thromboelastometry (“TEM”) assay. This TEM assay may be performed using the ROTEM Thromboelastometry Coagulation Analyzer (TEM International GmbH Munich, Germany), the use of which is well known (See, e.g., Sorensen, B., et al., J. Thromb. Haemost., 2003, 1(3): p. 551-8. Ingerslev, J., et al., Haemophilia. 2003. 9(4): p. 348-52. Fenger-Eriksen, C., et al. Br J Anaesth, 2005. 94(3): p. 324-9]. In the ROTEM analyzer, the blood sample is placed into a container (also called a cuvette or cup) and a cylindrical pin is immersed. Between pin and the interior wall of the container there is a gap of 1 mm which is bridged by the blood. The pin is rotated by a spring to the right and the left. As long as the blood is liquid (i.e., unclotted), the movement is unrestricted. However, when the blood starts clotting, the clot increasingly restricts the rotation of the pin with rising clot firmness. The pin is connected to an optical detector. This kinetic is detected mechanically and calculated by an integrated computer to the typical tracing curves (TEMogram) and numerical parameters (see FIG. 3).

In the ROTEM Thromboelastometry Coagulation Analyzer, the movement of the pin can be monitored by a computer including a processor and a control program. The computer is operable on the electrical signal to create a hemostasis profile corresponding to the measured clotting process. Additionally, the computer may include a visual display or be coupled to a printer to provide a visual representation of the hemostasis profile (called a TEMogram. Such a configuration of the computer is well within the skills of one having ordinary skill in the art. As shown in FIG. 3, the resulting hemostasis profile (i.e., a TEM tracing curve) is a measure of the time it takes for the first fibrin strand to be formed, the kinetics of clot formation, the strength of the clot (measured in millimeters (mm) and converted to shear elasticity units of dyn/cm 2) and dissolution of clot. The descriptions for several of these measured parameters are as follows:

CT (clotting time) is the period of time of latency from the time that the blood was placed in the ROTEM analyzer until the clot begins to form. In some embodiments, the CT time is the period of time from when the blood is placed on the ROTEM analyzer to when the amplitude reaches 1 mm wide.

CFT (Clot formation time): the time from CT until a clot firmness of 20 mm point has been reached. In FIG. 3, this CFT time is depicted as the time immediately following CT. CFT is reflective of the speed of clot formation.

alpha-angle: The alpha angle is the angle measured between the midline of the tracing and a line drawn from the 1 mm point tangential to the curve. This parameter is reflective of the speed of clot formation.

MCF (Maximum clot firmness): MCF is the greatest vertical amplitude of the trace. MCF reflects the absolute strength of the fibrin and platelet clot.

A10 (or A5, A15 or A20 value). This value describes the clot firmness (or amplitude) obtained after 10 (or 5 or 15 or 20) minutes after the clotting time (CT). In other words, and provide a forecast on the expected MCF value at an early stage.

LI 30 (Lysis Index after 30 minutes). The LI30 value is the percentage of remaining clot stability in relation to the MCF value at 30 min after CT.

ML (Maximum Lysis). The ML parameter describes the percentage of lost clot stability (relative to MCF, in %) viewed at any selected time point or when the test has been stopped.

A low LI 30 value or a high ML value indicates hyperfibrinolysis. While in normal blood fibrinolysis activity is quite low, in clinical samples a more rapid loss of clot stability by hyperfibrinolysis may lead to bleeding complications which can be treated by the administration of antifibrinolytic drugs.

Thus, parameters of interest in TEG or TEM assays include the maximum strength of the clot which is a reflection of clot strength. This is the MA value in the TEG assay, and the MCF value in the TEM assay. The reaction time (R) in TEG (measured in sec) and clotting time (CT) in TEG is the time until there is first evidence of clot; clot kinetics (K, measured in minutes) is a parameter in the TEG test indicating the achievement of clot firmness; and α in TEG or alpha-angle in TEM is an angular measurement from a tangent line drawn to the curve of the TEG tracing or TEM tracing starting from the point of clot reaction time that is reflective of the kinetics of clot development. (See Trapani, L. M. Thromboelastography: Current Applications, Future Directions”, Open Journal of Anesthesiology 3(1): Article ID: 27628, 5 pages (2013); and Kroll, M. H., “Thromboelastography: Theory and Practice in Measuring Hemostasis,” Clinical Laboratory News: Thromboelastography 36(12), December 2010; instruction manuals for the TEG instrument (available from Haemonetics, Corp.), and the instruction manual for the ROTEM instrument (available from TEM International GmbH), all of which documents are herein incorporated by reference in their entireties.

In some embodiments, the parameters (and hence the coagulation characteristics) are recorded by observation of different excitation levels of the sample as coagulation occurs. For example, where the container is a microfluidic cassette, or a particular channel in the cassette, the blood sample may be excited at a resonant frequency and its behavior observed by an electromagnetic or light source as coagulation occurs. In other embodiments the sample's coagulation characteristics may be observed for changes with a light source without exciting the sample.

Because a single cassette may have multiple containers (e.g., different channels in the cassette), the sample in a container contacted with an inhibitor of fibrinolysis is easily directly comparable to a sample in a container (e.g., in an adjacent channel in the same microfluidic cassette) that is not contacted with the inhibitor of fibrinolysis.

When no fibrinolysis occurs, the amplitude value at the MA on a TEG tracing and the amplitude value at the MCF on a TEM tracing stays constant or may decrease slightly due to clot retraction. However, as fibrinolysis occurs (e.g., in a hypocoagulable state), the curve of the TEG tracing and the TEM tracing starts to decay. The resultant loss in potential area-under-the-curve in the 30 minutes following Maximum Amplitude in the TEG assay is called the LY30 (see FIG. 2A). LY30, the percentage of lysis 30 minutes after the maximum amplitude point (expressed as a percentage of the clot lysed) and clot firmness (G, measured in dynes/cm²), indicates the rate of clot lysis. The corresponding value in the TEM assay is the LI30 value (see FIG. 3).

The LY30 is the usual metric of fibrinolysis. However, this parameter has some limitations including lack of sensitivity and specificity. Most importantly, the LY30 parameter takes at least 30 minutes to obtain. In normal patients, obtaining the LY30 in at least thirty minutes (because the 30 minutes must be added to whatever the time it took the clot to form in the first place) is adequate. However, in trauma patients, waiting the at least 30 minutes to determine if the patient's blood is clotting normally may be detrimental to the patient's outcome (e.g., the patient may bleed to death).

Thus, viscoelastic assays such as TEG and TEM measure the mechanical strength of the evolving blood clot over time. As the strength of the blood clot increases over time, a classic TEG curve (FIG. 2A) or classic TEM curve (see FIG. 3) develops. FIG. 4 provides a convenient side by side comparison of the TEG curves (upper part of the figure from a TEG apparatus) and TEM curves (lower part of the figure from a ROTEM apparatus). Note that for both TEG and TEM, sometimes only the upper half of the curve is depicted (see, for example, the TEG curve depicted in FIG. 7A).

There are, however, drawbacks to using the standard TEG and TEM assays. For example, it is difficult to measure the contributions of platelets and fibrinogen to the clot. Currently, the assays such as EXTEM and platelet-inhibitor containing FIBTEM (see FIGS. 5A and 5B, respectively) are run to try to determine the contributions of platelets and fibrinogen to clot strength. However, simple subtraction of assays run with and without platelet inhibitors is not an accurate measure of the contributions of platelets and fibrinogen because as FIGS. 5A and 5B show, platelet and fibrinogen contribution to clot strength is not additive.

Furthermore, perhaps the biggest drawback of all of the above listed parameters of TEG and TEM is the amount of time needed to obtain them. For example, while the MA (or MCF) and the LY30 (or LI30) in TEG and the MCF in TEM are considered two of the more important measurements of the clot in their respective assays, they are by definition obtainable only after the assay has been running for some time. For example, the LY30 and LI30 parameters are obtainable thirty minutes after the MA or MCF which, themselves, are obtainable after the R/ACT time and K time in the TEG assay, and after the CT time and the CFT time in the TEM assay. In the healthy volunteer whose data is depicted in FIG. 7A, Amax (i.e., MA) is not obtainable until 42 minutes after the start of the TEG analysis. During treatment of an individual with a traumatic injury (e.g., a person who has been in a car accident), minutes can make the difference between a positive outcome and a negative one.

Additionally, as FIG. 5C shows, if the patient has hyperfibrinolysis, an accurate reading of MA may be impossible. In this FIG. 5C, the antifibrinolytic agent tranexamic acid (TXA) is added to a blood sample to simulate a hyperfibrinolytic condition. As FIG. 3C shows, the true MA (i.e., Amax) is never reached in the hyperfibrinolysis sample, because the clot starts breaking down too soon. Yet accurate reading of the MA is very important for determining patient outcome.

The invention therefore stems, in part, from the desire to develop parameters that predict MA on a rational physical basis and encompass enough of the early TEG tracing to accurately predict its future trajectory. Results of earlier observational studies indicated that a major source of noisiness in the predictive value of early TEG parameters was the position of the parameters with respect to time as the dependent variable. As the rate of clot formation feeds back into the independent variable, the TEG curve shape is difficult to model over a wide dynamic range. Moreover, the inherent physics of clot formation are in essence time independent but are describable by the instantaneous state of the clot structure and concentration of the catalytic and stoichiometric participants in clot formation.

Thus, in some embodiments, the invention provides a model of clot formation in a time-independent domain, wherein TEG amplitude (A) is a proxy for clot strength and thus instantaneous clot structure and the instantaneous rate of clot formation at that state (dA/dT) becomes the dependent variable, such that:

dA/dT=f(A)

This function clearly defines the “accelerative” versus “coasting” phases of clot formation, a novel reconstitution of the traditional notions of initiation versus propagation in a non-temporal domain.

The implied function dA/dT=f(A) is then modeled using a physical model that bore a resemblance to the data derived from the human healthy volunteers. That physical model is:

dA/dT=aA
²/(e^bA−1)

which is a lower order modification of Planck's equation which contains only two fitting coefficients, namely a and b. Note that the values for a and b will vary in each patient. The values for a and b are how the fitting is done.

In some embodiments, A is the value of the Amplitude, e is a mathematical constant that is approximately 2.71828, a is a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method (a well-established data fitting method), and b is also a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method. In some embodiments, coefficient a=0.011 and coefficient b=0.104. In some embodiments, A goes from 0 to 60.

The invention, in some embodiments, therefore provides time-independent parameters. One such parameter is dAmax for the maximum in the rate of change of A. Thus, just as MA is the maximum amplitude is the time-domain TEG curve (see, e.g., FIG. 1A), the global maximum in the time independent TEG curve is dAmax. Note that “Amax” and “MA” are interchangeable terms and both refer to the maximum amplitude. The corresponding amplitude of dAmax called the critical amplitude or Acrit. In taking a derivative of the TEG curve, the derivative of Acrit appears at the peak of a curve plotting dA versus amplitude (in mm). Acrit occurs when dA is at its maximum value (i.e., Acrit occurs at dAmax). See, for example, FIG. 6C.

Accordingly, in a first aspect, the invention provides a method for identifying a patient likely to require a transfusion of at least six units of blood in six hours, the method comprising obtaining a coagulation characteristic value that is independent of time by using a viscoelastic analysis assay to analyze a sample of blood from the patient, the coagulation characteristic value obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient, wherein the coagulation characteristic value of the patient that is lower than the coagulation characteristic value that is independent of time of a control (e.g., a healthy volunteer) identifies the patient as likely to require a transfusion of at least six units of blood in six hours.

The invention stems, in part, from the development of the model

dA/dT=f(A)

which is based on taking the derivative of the TEG amplitude (A) parameter over the derivative of Time such that the function f(A) is arrived at. The modeling of this f(A) function allows the prediction of the maximal value of A (MA) based upon the trajectory during the accelerative phase of clot formation.

In some embodiments, the examples below describe the development of this model for f(A).

Thus, in some embodiments, the term “coagulation characteristic value” is meant any value obtained from viscoelastic analysis (e.g., maximum amplitude, LY30, A15).

One non-limiting coagulation characteristic value is Acrit, namely the point at which the rate of change of amplitude is at the maximum. In other words, Acrit is the amplitude at dAmax. Note that Acrit is not the same as MA (or Amax) because just as a moving vehicle does not immediately come to a halt once it stops accelerating, so too the amplitude does not immediately start declining once the rate of change of amplitude stops accelerating.

In some embodiments, the Acrit is obtained at least 10 minutes before the MA is obtained. In some embodiments, the Acrit is obtained at least 15 minutes before the MA is obtained.

As described below, in the examples, the blood of healthy volunteers have fairly high Acrit and modest dAmax. Patients who have significant hemorrhage (i.e., need 6 to 10 units of blood transfused in 6 hours) or massive hemorrhage have lower Acrit than the healthy volunteers. Patients who are injured (e.g., trauma patients) but who do not need more than 6 units of blood transfusion in 6 hours have moderate Acrit but high dAmax.

It should be noted that blood sample of the patient that is being analyzed should be kept on the viscoelastography analyzer, even after the Acrit parameter is taken.

Thus, in some embodiments, the invention uses information based on mathematical analysis of data emitting from a viscoelastic assay device (e.g., a thromboelastograph or a thromboelastometer) to predict whether a patient will require a blood transfusion.

In Example I below, an explanation of the mathematical derivation of Acrit and dAmax is described. Examples II-V describe working embodiments on healthy human volunteers and human patients (e.g., trauma patients).

Example I

In this Example I, a thromboelastoograph (TEG) device commercially obtained from Haemonetics, Corp. (Braintree, Mass.) is used.

Thromboelastography (TEG) is a diagnostic procedure that uses a thin wire probe to measure the strength of blood clots. This measurement is obtained by rotating a sample of blood around the thin wire probe. As the TEG machine rotates the blood, blood clots form and the wire probe adheres to the clot. When the wire probe adheres to the clot, it begins to move with the clot. The movement of the wire probe is recorded as an amplitude in millimeters. Therefore, a patient's clotting ability is directly related to the measured maximum amplitude. Understanding a patient's clotting ability is especially desirable in emergency trauma settings. Disclosed herein is the surprising discovery that the maximum amplitude can be accurately modeled in less time than it takes to measure the maximum amplitude. This can be done by measuring data to a point known as the critical amplitude and deriving the maximum amplitude from this data. An example of data obtained using TEG on a real patient sample is shown in FIG. 7A.

FIG. 7A shows a TEG curve for a healthy human volunteer, namely patient 20074B. As can be seen from FIG. 7A, the amplitude at time t=0 min until t=13.16 min is 0 mm. This is because the blood has not sufficiently clotted to adhere to the wire probe until the split at t=13.16 minutes. Until clotting forms, the wire probe remains motionless, and thus the amplitude is 0. In the art, this period of 0 amplitude may be known as the reaction time or “R value.” As the blood sample begins to clot, the wire probe adheres to the moving blood sample and starts moving. As the wire probe moves, the amplitude becomes non-zero.

The amplitude of the wire probe's motion is directly proportional to the strength of the clot. The Amax value is an important factor of a TEG analysis because it indicates the strength of the blood clot i.e., the overall stability of the clot. A computer may record and store the amplitude data as it is collected. The frequency with which amplitude data measurements are taken or sampled is known as the “sampling rate.” The sampling rate is easily modified by one having skill in the art, and frequently is a changeable parameter that is part of the data collection software. However, during a single set of data collection, a constant sampling rate is preferable. In other words, the time elapsing between measurements (τ) is preferably consistent. For example, the sample rate may be per minute, every second (hertz) or every millisecond (kHz), based on the number of data points and specificity desired. The sample rate may be limited by the maximum sample rate of the device. Alternatively, the sample rate may be dictated by the amount of data that we want to collect. Realistically, time measurements on the plot are shown to fractions of a minute. For example, a split point where the clot starts to form can be measured to t=13.166667 min. The time scale accuracy shows that the sample rate may be fractions of a second.

As data points are collected, it is possible to obtain the rate of change of amplitude (dA/dT). The collection of amplitude data points may be conceptualized as follows:

Amplitude data=[A₀, A₁, A₂, A₃, . . . , A_N−1, A_N] where A₁is the first amplitude data point collected, A₂is the second amplitude data point collected and so on until N data points have been collected. In this case A₀is the baseline amplitude immediately prior to data collection, e.g. 0.

Each amplitude data point is taken at a corresponding time interval.

Time data=[T₀,T₁,T₂,T₃, . . . T_N−1,T_N]

Because we can assume that the sampling rate is consistent throughout the entire period of data collection, it should be understood that the time between each measured sample is consistent. Specifically,

τ=T₁−T₀=T₂−T₁=T₃−T₂=T_N−T_N−1

In other words, if one records 5 samples per second over the course of 30 seconds, 150 data points are obtained with ⅕th of a second between each data point. It should be understood that the time units are dependent upon the sample rate chosen (amplitude values may be collected every millisecond, every second, every minute, etc.).

The rate of change of amplitude per time (dA/dT) for any N-th data point may be conceptualized as follows:

$\frac{{dA}_{N}}{dT} = [\frac{A_{N} - A_{N - 1}}{T_{N} - T_{N - 1}}]$

When sampling rate is consistent, the denominator is the same in every equation because the time intervals between all measurements are the same as a result of a consistent sampling rate. The rate of change of amplitude per time (dA/dt) for any N-th data point may be simplified as follows:

$\frac{{dA}_{N}}{dT} = [\frac{A_{N} - A_{N - 1}}{τ}]$

where τ is a constant equal to the inverse of the sampling rate, i.e. the time between sampling.

Thus, the parameter dA_N/dT is independent of time.

As shown in FIG. 7A, amplitude rapidly increases after the “split.” The rate of change of the amplitude continues to increase until a point labeled Acrit. At Acrit, amplitude increases at the fastest rate. After Acrit, amplitude continues to ascend, but at a slower rate than at Acrit. As the rate of change is calculated over the course of data collection by the computer, it is possible to identify at what time the maximum rate of change (Acrit) occurs. For example, rate of change (dA/dT) values will continue to increase until a maximum rate of change is reached (Acrit), and then rate of change (dA/dT) will decrease. However, just because the rate of change (dA/dT) decreases, it should be noted that amplitude may still be increasing, albeit at a slower rate. A routinely skilled practitioner can review the data emitting from the TEG analysis of a blood sample and detect Acrit, the point at which the rate of change of A stops accelerating and starts slowing down. Of course, a computer can detect that the maximum rate of change (dA/dT) has occurred and identify point Acrit as it occurs.

The amplitude eventually reaches a maximum value, shown as Amax on FIG. 7A. This Amax value provides valuable diagnostic data about the strength of the clot and is also referred to as maximum amplitude (MA) or maximum clot firmness (MCF). In healthy patients, fibrinolysis occurs after Amax, as the wire probe begins to slip, resulting in an amplitude decrease as shown.

In FIG. 7A, Amax occurs approximately 42 minutes after starting the thromboelastography analysis (i.e., putting the blood sample into the TEG machine). The Amax value is approximately 59.02 mm. Because Amax dictates blood clot strength as well as other physiological parameters, in certain emergency patient care situations the sooner Amax can be determined the better. Thus in emergency trauma settings, it is desirable to determine the value for Amax well before the 42 minutes required to reach Amax. As discussed below in Example II, the health and well-being of a trauma patient is assessed at six hours. Therefore, 42 minutes is a very long time to have to wait to determine patient outcome.

Thus, embodiments of the present invention use an empirically derived equation to model Amax from values of Acrit. As a result, Amax (i.e., MA) can be estimated within an accuracy level appropriate to determine relevant physiological factors at the time of Acrit, approximately half the time required to measure Amax.

In some embodiments of the invention, a computer may record amplitude and dA/dT data as discussed above in real time. The data collection may, for example, look something like Table 1 below.

TABLE 1

dA/dT

Amplitude
(mm/time

(mm)
unit)

10
0.60135

11
0.622166

12
0.637843

13
0.648832

14
0.655564

15
0.658451

(A_crit)

16
0.657884

As can be seen, when the Amplitude is 15 mm, the rate of change (dA/dT) has reached its maximum (Acrit) at 0.658451 mm/time unit. When the Amplitude is 16 mm, dA/dT begins to descend (note that Amplitude does not descend, only its rate of change (dA/dT) has slowed). In FIG. 7A, Acrit occurs when Amplitude reaches 15 mm at approximately 17 minutes. That is all the time and data that needs to be collected to obtain a calculated Amax using the empirically derived equation described below. As should be understood, obtaining an Amax value from an Acrit value provides a substantial benefit in terms of the time necessary to obtain a value for Amax.

In accordance with the present invention, the inventors have discovered that patient data collected from 161 healthy volunteers could be modeled with empirically derived equation: dA/dT=aA²/(e^bA−1) This equation represents the derivative, or rate of change, of the Amplitude in respect to time. A is the value of the Amplitude, e is a mathematical constant that is approximately 2.71828, a is a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method (a well-established data fitting method), and b is also a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method. To accurately model dA/dT, in some embodiments, the data is collected all the way to point Acrit. After Acrit, the dA/dT equation can be solved for the missing coefficients a and b by a computer in seconds.

FIG. 7B is a graph of dA/dT=aA²/(e^bA−1) with coefficient a=0.011 and coefficient b=0.104 when A goes from 0 to 60:

Theoretically, A_maxshould be the point that dA/dT reaches 0. The rate of change (dA/dT) should then become negative to indicate that amplitude is dropping after Amax. Because of the empirical equation chosen, dA/dT=aA²/(e^bA−1), dA/dT will never achieve a negative value unless one of the coefficients is negative. However, in order to fit the model shown, coefficients a and b should both be positive values. A potential issue arises with the use of positive coefficients. Since Amax is the maximum amplitude, all amplitude measurements thereafter should be less than Amax. In other words, the derivative after Amax should be negative. However, as a result of the simplistic equation used to model Amax behavior, certain embodiments of the model may not achieve a negative value for dA/dT. This particular graph of dA/dT v. Amplitude shown in FIG. 7B will only approach dA/dT=0 as Amplitude approaches infinity. However, as we know, Amplitude never actually reaches infinity. Therefore, there may be some specific cutoff threshold value. This value may be set by a computer, for example. For example, setting the requirement that Amax occurs when the change of Amplitude over time eventually slows down to some value, e.g. when dA/dT=0.1.

The coefficients a and b are responsible for determining where the graph of dA/dT will peak, and how quickly it will return to 0 after it peaks. In general terms, coefficient a is responsible for raising the peak of the graph, while coefficient b is responsible for determining how quickly the peak will descend towards 0. Both coefficients are relevant because they influence when dA/dT will reach the cutoff threshold for determining the calculated A_maxvalue. A larger a value will result in a correspondingly larger peak value. A larger b value will result in a graph that descends more rapidly. For example, when coefficient a doubles to 0.022, there is a correlated elevation in the peak value, and the calculated A_maxvalue, as shown in FIG. 7C.

If a calculated Amax threshold occurs when dA/dT=0.1, the graph shown in FIG. 7C does not extend far enough along the amplitude axis to show what calculated Amax would be i.e. Amax would be greater than 60. The patient having coefficient a value of 0.022 has a quantitatively greater clotting strength than the patient having coefficient a value of 0.011.

When coefficient b doubles to 0.208, the graph approaches 0 more quickly as shown in FIG. 7D.

In this case, if calculated Amax were to occur at a threshold when dA/dT=0.1, Amax would occur well before Amplitude=60. In other words, the patient with coefficient b value of 0.208 has significantly weaker clotting than the patient with coefficient b value of 0.104. Noticeably, this increase in coefficient b has dropped the value of Acrit as well. As can be understood, the coefficients do not operate on isolated segments of the graph, but rather work together to produce the entire waveform, including the values for Amax and Acrit. However, as a general concept, a larger a coefficient makes the plot peak larger, and a larger b coefficient brings the plot peak down and causes a more rapid descent towards dA/dT=0. Each a and b coefficient may vary from patient to patient. The a and b coefficients of each patient allow us to create a custom model for each patient based on the Acrit data acquired. For example, as shown in FIG. 7E, data points may be obtained as shown by the squares up until point Acrit.

A program, such as MatLab (commercially available from The MathWorks Inc., Natick, Mass.), may be used to fit the dA/dT data points to the empirically derived equation for dA/dT using the least squares method. Again, the dA/dT data points may be obtained by using the Amplitude data acquired from the TEG procedure. A computer may automatically calculate the dA/dT values.

Amplitude data=[A₀,A₁,A₂,A₃,A₄, . . . A_CRIT−1,A_CRIT,A_CRIT+1]

The rate of change of A₁for example is (A₁-A₀) divided by τ, the time between data acquisition measurements.

$\frac{dA}{dT} = [\frac{A_{1} - 0}{τ}, \frac{A_{2} - A_{1}}{τ}, \frac{A_{3} - A_{2}}{τ}, \dots \frac{A_{CRIT} - A_{CRIT - 1}}{τ}, \frac{A_{CRIT + 1} - A_{CRIT}}{τ}]$

The values for dA/dT, that may be obtained using the above equation, are plotted against the Amplitude values up to Acrit. This produces the first part of the waveform up to the peak of the plot. The empirical equation:

$\frac{dA}{dT} = \frac{a \cdot A^{2}}{e^{bA} - 1}$

is then fit to the data points up to Acrit using the least squares method. By fitting the data to the empirical equation, coefficients a and b are determined. This may be done by a computer. Fitting the data to the equation gives coefficients a and b values that produce the best fit to the dA/dT equation using the least squares method. Once the a and b coefficients are obtained from the collected data points up to Acrit, the equation may be extended to Amax. A graph may be used to find the calculated Amax by simply plugging in the best fit a and b coefficients into the dA/dT equation and seeing when the Amax threshold level is reached. As discussed above, the derivative, dA/dT value will approach 0 as Amplitude goes to infinity. This is a property of the model equation chosen. As a result, a trigger threshold dA/dT value may be used to determine when Amax occurs. This trigger threshold can be determined based on empirical data, or when the derivative has reached an adequately low level, for example when dA/dT drops to less than 0.1 mm/time unit.

Example II

The dAmax and Acrit values were obtained from four classes of patients, namely healthy volunteers, trauma patients with no significant bleeding (i.e., hemorrhage), trauma patients with significant hemorrhage needing 6-10 units of blood in 6 hours, and trauma patients with massive hemorrhage needing 10 units of blood in 6 hours or dying of exsanguination in 6 hours.

Blood was collected and analyzed according to standard methods. By way of example, from healthy volunteers, citrated whole blood samples were obtained from healthy volunteers accordingly to standard methods. Similar techniques are performed on blood samples from trauma patients.

Briefly, venipuncture is performed with a 21-gauge needle in an antecubital vein, and blood is collected into evacuated containers containing 3.2% citrate (e.g., a 3.5 mL plastic Vacutainers® containing 3.2% citrate). By a “healthy individual” or “healthy volunteer” is meant a healthy individual who is of reproductive age. For example, if the patient is a human, a healthy volunteer is man or woman between the ages of about 14 years old to about 44 years old, or between about 18 years old to about 40 years old. For each sample of blood, 340 uL of the citrated whole blood (i.e., from the Vacutainers that contained 3.2% citrate) are added to a cup containing 20 μL 0.2 mol/L of CaCl₂and the assay performed on a TEG 5000 Thrombelastograph system (commercially available from Haemonetics, Inc., Braintree, Mass.). Note that if a multi-channel cassette is used, the channel for the particular sample is pre-loaded with 20 μL 0.2 mol/L of CaCl₂, to which 340 uL of the citrated whole blood is added.

Table 2 provides the raw data (CRD) from healthy volunteers. Note that in the tables, “CFF” stands for citrate functional fibrinogen TEG, where the extrinsic pathway is activated by the addition of tissue factor and calcium, while the platelet aggregation is inhibited (due to the presence of a monoclonal glycoprotein GPIIb/IIIa receptor antagonist in the Functional Fibrinogen reagent, commercially available from Haemonetics Inc., Braintree, Mass.). Therefore, the CFF number represents the amount of fibrinogen contribution to the strength of the clot. “CFT” is the citrated rapid TEG, which adds kaolin to activate the intrinsic pathway. Thus, the CFT number represents the clot strength as contributed by both platelets and fibrinogen. “CN” is simply native blood or native blood that has been citrated but has no kaolin or tissue factor added. Table 3 provides the healthy volunteer data sorted by CN MA. Table 4 provides the raw data (CRD) from trauma patients sorted by significance of hemorrhage. Table 5 provides the trauma patient data sorted by significance of hemorrhage, where the errors are eliminated. The data from these patients were taken from the TEG apparatus (commercially available from Haemonetics, Corp., Braintree, Mass.) using the computer software provided with the apparatus and additional software for speedy calculations. Note that the data was taken from native TEG (i.e., citrated or non-citrated whole blood without the addition of clotting factors or enhancers of clot formation such as kaolin). These data were then used to calculate Acrit and dAmax values using the equations described above.

In FIGS. 8 and 9, dAmax values were then plotted as a function of Acrit. The data plotted are healthy volunteers (triangles), patients with no massive hemorrhage (squares), patients with significant hemorrhage (circles), and patients with massive hemorrhage (diamonds). A patient with no massive hemorrhage (or no significant hemorrhage) is a patient who does not need more than 6 units of blood in 6 hours. A patient with significant hemorrhage needs between 6 units and 10 units of blood in 6 hours. And a patient with massive hemorrhage is a patient who either needs more than 10 units of blood in 6 hours or less, or who dies of blood loss in 6 hours.

As shown in FIG. 8, patients with massive hemorrhage (orange diamonds) had slightly lower dAmax and slightly lower Acrit values than patients with no significant hemorrhage (blue squares). The difference between both of these populations is striking when compared to healthy volunteers (green triangles) who had higher Acrit values and lower dAmax values. FIG. 9 shows that patients with significant hemorrhage (yellow circles) overlap the patients with massive hemorrhage, but had very little overlap with patients with no significant hemorrhage.

The data is FIGS. 8 and 9 show that healthy volunteers form a tight cluster of fairly high Acrit, and modest dAmax. Furthermore, patients who are injured but do not have significant hemorrhage (i.e., do not require transfusion of more than 6 units of blood in 6 hours) will increase dAmax dramatically (i.e., by increasing generation of thrombin). By doing so, this increase in dAmax in injured patients will shift Acrit values lower. This may be due to the thermodynamic efficiency of clot formation being lower at higher velocity (a common feature of enzymatic chemistry) or simply that there are consumptive processes at work. However, massive bleeders will fail to up-regulate their dAmax and also have a subnormal (i.e., low) Acrit, either from catalysis failure or exhaustion of resources.

Example III

To even more accurately predict the MA, the discontinuity with the model near MA was addressed by taking the area under the tracing and relating it to MA (i.e., Amax). Since there is no closed form solution to relate the MA in the time domain back to the integrated differential equation in the amplitude domain, the relationship will be modeled. By dimensional analysis the solution to the integral of dA/dT with respect to A from A=0 to A=∞ should have units equivalent to A². Calling this area product “Q”, this provided a solution that must be in the form Q=c(Amax²)+d where c is a function zero order in Amax and T (note that Amax is used synonymously with the time-dependent variable “MA”). The simplest model for this is thus merely a linear fit to existing healthy volunteer and patient data.

The results described here provide the identification of new parameters that can be obtained very early, and that ae reflective of the maximum amplitude. The maximum amplitude is one of the most important predictors of outcomes for trauma patients, and whether or not such patient will require a blood transfusion. In healthy volunteers, the MA occurs typically between about 15 to about 35 minutes after the start of the viscoelastic assay. A lower MA may reflect a hypocoagulable state, such as platelet dysfunction or thrombocytopenia, and thus identifies a patient that is likely to require a blood transfusion. Since the Acrit is reflective of MA, an Acrit that is lower than an equivalent MA at about 15 to about 35 minutes identifies the patient as likely to require a blood transfusion.

As discussed in more detailed in Example IV below, FIG. 15 shows the data points of MA plotted against the area under the curve (see red shaded area in FIG. 10) fit to the model. The area under the curve is clearly shown in FIG. 10 (red shaded area). This red shaded area stops in FIG. 10 at “crit” (i.e., Acrit), which occurs when dA is at its maximum value.

FIGS. 11 and 12 are two graphs showing the correlation between plotting the % sensitivity versus % specificity for the rate of change of the time-independent TEG area under the curve (TITAUC). The straight diagonal line shows a 50/50 chance of prediction of a patient with significant hemorrhage (FIG. 11) or massive hemorrhage (FIG. 12). Plotting the area under the curve (see FIG. 10), FIG. 11 shows that using the Acrit and dAmax values, a patient with significant hemorrhage could be predicted with an accuracy of 83.65% and FIG. 12 shows that using the Acrit and dAmax values, a patient with massive hemorrhage could be predicted with an accuracy of 88.23%.

Example IV

The MA of a TEG curve is the hypothetical representation of the maximum clot strength which represents a combination of platelet and fibrinogen contributions to the clot's architecture and ultrastructure. However, this MA number is not a simple additive sum, as platelets and fibrinogen are not merely a homogeneous admixture (see FIGS. 5A and 5B). Instead, platelets form nodes in the fibrin network which catalyze the formation of and organize the network as well as actively generating internal stresses by their contraction which enhance the shear and tensile strength of the clot. The complex, non-additive relationship of platelets and fibrinogen to clot strength is exemplified by the fact that an entirely platelet-free clot loses around 80% of its strength, but a fibrinogen free clot loses 100% of its strength.

Thus, simple differential thromboelastography analysis between samples with and without platelet inhibitors is not a fully accurate measure of the individual contributions of platelets and fibrinogen, or more importantly which of these elements is deficient in the setting of a given individual, such as a trauma patient who may or may need a blood transfusion.

To obtain a faster parameter reflective of MA, the TEG tracings of the 161 healthy volunteers were analyzed and more information was extracted from these TEG tracings (also referred to as TEG curves) to obtain novel parameters. These tracing are drawn initially in the time domain (see. e.g., FIG. 4A or 5A), but can be transformed into other coordinate systems that reveal other information encoded in the tracing. For example, the reference frame of the TEG tracings can be arbitrarily shifted to a set of axes which appear to encode the greatest information content.

Another method is to deliberately transform the data into a new set of coordinates may be based on inherent physical properties of the system, for example transforming a complex signal read out in the time domain into the frequency domain to reveal hidden patterns (e.g., a fourier transform).

Similarly, one can transform a signal in the time domain to a signal in the amplitude domain.

FIG. 6A, for example, classic TEG tracing of one typical healthy volunteer. In FIG. 4A, time (in min) is on the X axis and amplitude (in mm) is on the Y axis).

A term of interest, such as the amplitude, can be pulled out of the non-periodic signal (e.g., a TEG tracing) and recast as an independent variable that term (i.e., the amplitude) as the domain, with the rate of change of amplitude as the new dependent variable, dA. This is shown in FIG. 6B. FIG. 6B thus effectively removes the time variable.

Thus, just as MA is an obvious feature of the time-domain TEG curve, a global maximum exists in the time independent TEG curve. This is called the dAmax for the maximum in the rate of change of A, the corresponding amplitude is called the critical amplitude or Acrit. Acrit is shown on FIG. 6A and FIG. 6C. In FIG. 6C, it is clear that Acrit occurs at dAmax (i.e., at the time that dA is at its maximum value. In the healthy volunteer shown in FIG. 6A, Acrit occurs when the dA is 0.68 and the A is 11.64 mm (see FIGS. 6A and 6C). The Amax is 55.62 mm, and occurs at approximately 38 minutes (see FIG. 6A).

The TEG tracing of another healthy volunteer is shown in FIG. 7A. In FIG. 7A, it is evident that the Acrit parameter is obtainable before 5 minutes after the beginning of clotting (i.e., before the A5 time). In the patient shown in FIG. 7A, the A5 parameter (i.e., 5 minutes after clotting) is obtained 18.17 minutes after the start of the TEG assay. However, the Acrit parameter is obtained at approximately 17 minutes after the start of the assay.

Thus, in some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 5 minutes after the blood starts clotting in a viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 10 minutes after the blood starts clotting in a viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 15 minutes after the blood starts clotting in a viscoelastic assay.

In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 18 minutes after the start of the viscoelastic assay (i.e., after the blood sample from the patient is placed into the viscoelastic analyzer for analysis). In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 20 minutes after the start of the viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 25 minutes after the start of the viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 30 minutes after the start of the viscoelastic assay.

FIG. 13 shows that the mapping of Acrit and Amax parameters of the tracing of FIG. 7A in a Planck-like fit is stable. (See red line in FIG. 14A, fit up to the maximum at Acrit).

The behavior in the TEG tracings suggests some degree of coupling with some hidden variables. Pulling these hidden variables out requires integrating this differential equation:

dA/dT=f(A)

This equation is an implied function and is clearly a nonlinear differential equation even in the case of the simplest model. So solving in closed form is likely not possible and there is a good chance that its expansion will not converge.

Note that initially the TEG tracings from the healthy volunteers were modeled with the empirically derived equation

dA/dT=aA
²/(e^bA−1)

Fitting to this model equation was used to test the robustness of the fit. The same fitting was done, varying only a and b, to only the accelerative phase of the curve, prior to the maximum value of dA (dAmax).

As a first step to deriving this model, a curve fitting was attempted as a methodology for prediction of early from late (notably attempts to do this in the time domain have been notoriously unsuccessful). The goal was to develop the simplest possible model for interpolation and extrapolation in order to avoid the pitfalls of overfitting. Furthermore, the model developed is based on other natural phenomena not simply a polynomial. Thus, a lower order modification of Planck's equation on this basis, as it contains only 2 fitting parameters in its simplest form. These are shown in FIG. 13, and the fit on the two parameters (Acrit and Amax) is stable.

However, as shown in FIG. 14, the fit converges with increasing data. This convergence is an important characteristic of predictive stability. On the x axis in FIG. 14 is the time off-set from Acrit in minutes. As time increases, there is an increasing progression of inclusion of data points in the TEG tracing. 0 on the x-axis in FIG. 14 is Acrit. On the y-axis in FIG. 14 is the normalized difference in area under the curve between the model and the actual Amplitude domain data. Note that this is simply a convenient representation of the aggregate error of the fit. The root mean square deviation (or root mean square error) (RMSE) for each point can also be used to obtain an equivalent result.

As FIG. 14 shows, the more the TEG curve is allowed to progress before attempting the fit, the better the prediction, but this rapidly converges near Acrit. This increasing fit and the rapid convergence near Acrit provides that the model is sound.

Thus, in many individuals' TEG tracings, the accelerative phase fit was nearly superimposable with the full tracing fit all the way to MA. Interestingly, even when the least squares fit is poor, the two model trajectories appear to converge at MA (see FIG. 13). This is suggestive that there is a valid physical basis to the trajectory equation. However, the behavior of the time-independent TEG tracing (TITT) and the model diverge near MA (see FIG. 13). This is because the actual TITT is not smooth in this limit, and is no longer a explicitly definable function as it doubles back on itself as the curve decays based on physical processes distinct from its formation, whereas the model is asymptotic at the X-axis (i.e. in the model the clot grows forever albeit at rate limit 0 at infinity).

To map this back to the MA, since the model is asymptomatic at the x-axis, no explicit coordinate pair defines MA. Therefore, this is analogous to infinite, infinitely slow growth of the clot. The model

dA/dT=aA
²/(e^bA−1)

is solved, yielding A(t). Theoretically A(t) could then be evaluated at infinity to yield the MA, but of course this is not possible.

Instead the area under the model curve at infinity is evaluated which should have units of mm-squared per second which obviously yields infinite amplitude when evaluated at T=infinity. This can be done by taking the area under the tracing and relating it to MA. Since there is no closed form solution to relate the MA in the time domain back to the integrated differential equation in the amplitude domain, the relationship will be modeled. By dimensional analysis, the solution to the integral of dA/dT with respect to A from A=0 to A=∞ should have units equivalent to A². Calling this area product “Q”, this provided a solution that must be in the form Q=c(A_max²)+d where c is a function zero order in Amax and T (note that Amax is used synonymously with the time-dependent variable “MA”). The simplest model for this is thus merely a linear fit to existing healthy volunteer and patient data.

In fact, the area under the curve converges itself and should have an explicit relation (albeit unknown) to the solution to the differential equation which must include this integral. Thus, evaluated the explicit integral, a and b are unitless constants and yield a result in terms of Amplitude squared.

$\int_{0}^{\infty} \frac{{aA}^{2}}{e^{bA} - 1} dA$

Therefore, a function of this area was hypothesized to yield MA. This was then tested against the actual data.

As shown in FIG. 15, this relationship is stable even when the fit is run only to Acrit and yields the very simple prediction:

MA is approximately equal to 15(ln Q)+12 mm

The test for fit was on a subset of the actual human data where the original curve fit was good (see FIG. 15). Note that the “goodness” of the curve fit was not being tested. Rather, the test was whether the hypothesis that MA bears an explicit mathematical relation to the integral in question was plausible. Our test revealed that the MA clearly bears an explicit mathematical relation to the integral. This appears to conform to a logarithmic fit but it is actually more likely a fractional power.

Thus, these studies show that Acrit occurs very early—even before the A5 min or A10 min marks which some practitioners advocate as a means of early estimation of MA (see FIG. 7A). Note that FIG. 7A (and FIG. 6A) is a native tracing which accounts for the long R-time.

With these new parameters (e.g., Acrit, and dA), numerous objectives can be achieved in the quest to predict late TEG events in a very rapid fashion.

Example V

Massive hemorrhage is a significant cause of death in trauma patients.

However, all the information needed to determine if a patient (e.g., a trauma patient) will require a large blood transfusion within six hours (or die) is contained within a blood sample taken from that patient. Currently, some of the best indicators of significant or massive hemorrhage in the patient take over 40 minutes to obtain (i.e., the MA value). The methods described herein, and the new parameters (e.g., dAmax and Acrit) allow accurate prediction of the MA in a much fast time (e.g., less than twenty, or less than fifteen, or less than ten, or less than five minutes after the start of the viscolastic assay).

In addition, the methods and parameters described herein are useful for determining what part of the coagulation process is not functioning normally in a patient who might experience significant or massive hemorrhage. As discussed above, hemostasis is a complicated, tightly regulated process involving multiple factors (see FIG. 1). The intrinsic pathway to coagulation is initiated by providing a surface on which the clotting factors can aggregate. To do this using a viscoelastic assay, reagents such as kaolin are added to provide that surface. This surface contact can activate Factor XII to form Factor XIIa which then activates Factor XI to form Factor XIa. In other words, the surface of kaolin is acting like Kininogen and kallikrein in FIG. 1. The extrinsic pathway is the tissue factor pathway, and provides a thrombin burst during traumatic injury. As shown in FIG. 1, trauma acts via Factor VIIa and tissue factor to activate Factor X to form Factor Xa.

Platelets also play a role in clot formation. During injury, platelets immediately form a plug at the injury site. The clotting cascade pictured in FIG. 1 occurs simultaneously, and contributes fibrin to strengthen the clot. Thus, platelets and fibrin (and its precursor, fibrinogen) contribute to clot strength; however, their contributions are not additive (see FIGS. 3A and 3B). It would be useful, however, to determine if problems with clotting are due to the fibrin contribution or the platelet contribution, because identifying the source of the problem could lead to better patient treatments. For example, if the lack of clotting was the result of low platelet activation, the patient could be treated with a platelet activator such as Factor VIIa, desmopressin, and thrombopoietin and thrombopoietin mimetics. Conversely, if the lack of clotting was the result of low fibrinogen activation to produce fibrin, the patient could be treated with thrombin and/or fibrinogen to increase fibrin production.

Surprisingly, the methodologies described herein are able to detect contributions of fibrinogen to clot strength, and are able to detect contributions of platelets to clot strength. In FIG. 16, increasing amounts of fibrinogen are added to a blood sample ranging from the hypo to hypercoagulable range while platelet count is held constant. These spiked samples were subjected to viscoelastic analysis, and the dAmax values plotted against the amount of added fibrinogen. As shown in FIG. 16, fibrinogen activity demonstrated a very tightly correlated sigmoid relationship to dAmax. In other words, in an artificial system (i.e., using spiked blood), dAmax was found to be correlative to functional fibrinogen level, and therefore is a marker of the contribution of fibrinogen (and fibrin) to a blood clot.

Similarly, in order to derive correlates of time-independent TEG parameters to total platelet function, another artificial system was set up in which platelets were depleted from whole blood by differential centrifugation, and then counted. The blood samples containing various amounts of platelets were then subjected to viscoelastic analysis and the dAmax value multiplied by the Acrit value to arrive at a “critical product”. This “critical product” value was plotted against the number of platelets in the sample in FIG. 17, and the resulting graph shows a clear linear relationship between the product of dAmax and Acrit (the “critical product”) and total platelet count.

Thus, using the methods and parameters identified herein allows the dissection of the blood clotting into the contributions of fibrinogen and platelets.

Finally, as shown in FIG. 18, the area under the receiver operating characteristic curve (ROC) of the time-independent TEG (TITAUC) for patients with massive hemorrhage is more accurate at predicting patients who will suffer massive hemorrhage compared to the AUC for maximum amplitude (MA; red line), the AUC for the alpha angle (purple line), the AUC for activated clotting time (ACT; brown line) and the AUC for the International Normalization Ratio (INR) (green line).

The embodiments of the invention described above are intended to be merely exemplary; numerous variations and modifications will be apparent to those skilled in the art. All such variations and modifications are intended to be within the scope of the present invention as defined in any appended claims.

TABLE 2

CRT
CN
CFF

CRT Amax
CN Amax
CFF Amax
CRT Acrit
CN Arit
CFF Acrit
dAmax
dAmax
dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

20064
62.4453125
57.59375
22.6015625
1.9296875
16.82421875
3.60546875
1.453125
0.8203125
0.5390625

20066
57.40625
52.2265625
17.3515625
1.25
17.84375
2.29296875
0.984375
0.46875
0.3515625

20067
59.2578125
59.9609375
21.8046875
16.15625
12.78125
2.609375
0.984375
0.890625
0.375

20068
63.359375
55.671875
24.453125
1.37890625
14.97265625
4.49609375
1.0546875
0.5859375
0.6328125

20069
68.65625
64.484375
25.484375
2.85546875
15.828125
5.5390625
2.0390625
0.9375
0.84375

20070
61.7890625
56.046875
18.03125
14.01171875
17.6328125
3.58203125
1.1953125
0.5625
0.3984375

20072B
58.0390625
47.9375
16.1328125
1.71875
14.1875
3.37109375
1.125
0.328125
0.3046875

20073D
68.234375
62.515625
21.6640625
20.4453125
18.2421875
4.33203125
1.3125
0.609375
0.5390625

20074B
63.9921875
59.0234375
22.484375
5.33984375
13.6484375
3.8046875
1.1953125
0.65625
0.65625

20075D
69.59375
62.8203125
24.3828125
16.63671875
16.578125
5.421875
1.4765625
0.703125
0.5625

20076B
59.9140625
51.78125
17.2109375
5.45703125
16.2734375
2.24609375
1.0546875
0.375
0.3515625

20077D
61.34375
57.7578125
16.2265625
15.8515625
14.0234375
2.52734375
1.03125
0.515625
0.3515625

20078B
56.1640625
50.5859375
18.265625
1.21484375
15.83984375
3.62890625
1.1015625
0.4921875
0.3046875

20079D
61.015625
48.078125
18.3359375
6.2421875
17.10546875
3.37109375
1.265625
0.3984375
0.3984375

20080B
64.2265625
61.5078125
25.4140625
18.60546875
18.640625
4.63671875
1.2421875
0.65625
0.4921875

20081D
69.5234375
63.0546875
25.8125
3.23046875
19.96484375
5.59765625
1.6171875
0.4921875
0.6328125

20082B
55.53125
54.6171875
18.3125
0.93359375
14.5859375
3.06640625
0.9140625
0.515625
0.3515625

20083B
67.4375
56.3046875
22.4140625
17.10546875
21.06640625
4.6953125
1.2890625
0.3984375
0.609375

20084D
62.1875
57.6640625
19.578125
14.3984375
19.84765625
3.21875
1.078125
0.4453125
0.328125

20085D
62.5390625
52.625
19.8359375
1.73046875
14.45703125
4.109375
1.3828125
0.4921875
0.28125

20086B
62.2578125
54.125
22.7890625
1.859375
14.87890625
4.70703125
1.171875
0.4921875
0.5390625

20087D
69.4765625
64.953125
23.984375
18.1015625
18.7578125
5.8671875
1.40625
0.796875
0.46875

20088B
61.625
54.8984375
17.609375
19.33203125
19.8359375
2.99609375
0.9140625
0.421875
0.3046875

20090B
60.40625
50.421875
20.7265625
6.03125
18.5703125
4.16796875
1.078125
0.46875
0.4921875

20091D
66.453125
62.9140625
23.46875
2.01171875
18.4765625
4.30859375
1.4765625
0.65625
0.4453125

20092B
69.3125
60.546875
21.6875
14.6328125
18.81640625
4.33203125
1.640625
0.6328125
0.3515625

20093D
71.5625
63.8515625
25.3671875
19.625
17.1875
5.75
2.484375
0.5625
0.65625

20094B
65.28125
61.2265625
20.984375
2.57421875
16.94140625
2.8203125
1.4765625
0.7265625
0.46875

20095D
67.7421875
62.46875
23.890625
17.45703125
17.703125
4.00390625
1.2890625
0.46875
0.3984375

20096B
64.53125
54.6875
19.2734375
5.59765625
13.7421875
3.6875
1.1953125
0.421875
0.1875

20097D
66.640625
69.359375
20.375
14.10546875
16.49609375
3.44140625
1.2421875
1.0078125
0.3984375

20098B
61.953125
57.59375
17.9609375
1.66015625
20.1875
3.39453125
1.1015625
0.515625
0.3984375

20099D
58.578125
59.328125
18.3828125
13.42578125
12.6875
3.546875
0.8203125
0.5625
0.1875

20100B
52.90625
45.2421875
20.8671875
1.49609375
15.91015625
3.1015625
1.3359375
0.5390625
2.203125

20101D
60.3828125
53.09375
18.875
1.4140625
16.44921875
3.76953125
1.359375
0.4921875
0.4453125

20102B
68.9140625
61.0625
25.9765625
6.5
19.8828125
5.99609375
1.5
0.5625
0.6796875

20103D
72.5703125
67.9765625
28.109375
10.2734375
24.265625
6.359375
1.921875
0.796875
0.75

20104B
65.3515625
64.6953125
27.4296875
17.41015625
24.21875
7.68359375
1.0546875
0.703125
0.4921875

20105D
60.734375
55.71875
19.1796875
1.26171875
22.0625
4.1796875
1.3359375
0.375
0.234375

20106B
62.046875
52.4375
23.5859375
1.89453125
14.57421875
5.375
1.7578125
0.6328125
0.375

20108B
54.5234375
46.6484375
16.296875
15.9453125
15.53515625
2.73828125
0.84375
0.4453125
0.2578125

20109D
62.1640625
58.71875
20.3046875
1.70703125
18.78125
4.68359375
1.5234375
0.609375
0.5390625

20110B
56.28125
47.6328125
16.953125
1.09765625
16.859375
2.796875
1.0078125
0.421875
0.328125

20111D
61.53125
55.2265625
18.59375
1.37890625
16.484375
5.3046875
1.2890625
0.515625
0.46875

20112B
62.8203125
57.640625
21.453125
1.71875
21.0078125
4.49609375
1.453125
0.421875
0.4921875

20113D
65.046875
61.6953125
24.3125
16.2734375
18.53515625
3.7578125
1.5
0.6328125
0.515625

20114B
57.8984375
52.34375
20.046875
11.75
17.17578125
3.546875
0.890625
0.4453125
0.46875

20115B
61.8359375
52.90625
18.359375
1.5546875
22.4375
3.40625
1.265625
0.421875
0.375

20116D
58.4375
56.796875
19.6953125
1.70703125
17.08203125
2.9375
1.4765625
0.4453125
0.421875

20117B
56.28125
51.4296875
17.890625
12.125
18.55859375
2.92578125
0.984375
0.3984375
0.3984375

20118D
67.578125
63.8515625
22.34375
3.55859375
16.7890625
3.58203125
1.8984375
0.796875
0.6328125

20119B
67.0390625
63.7109375
22.203125
13.87109375
17.66796875
4.0390625
1.2890625
0.6328125
0.421875

20120D
67.1796875
59.7734375
22.7890625
14.48046875
17.64453125
5.19921875
1.4296875
0.5859375
0.6328125

20121B
58.0859375
59.9375
18.6171875
13.30859375
14.3984375
3.08984375
1.1015625
0.890625
0.5390625

20122D
69.5234375
62.84375
26.140625
11.1171875
15.8984375
4.61328125
2.109375
0.5625
0.6796875

20123B
55.765625
56.5859375
21.7578125
1.578125
17.22265625
5.01171875
1.359375
0.4921875
0.6796875

20124D
61.203125
53.234375
20.890625
2.08203125
18.3828125
9.59375
1.4765625
0.609375
0.375

20125B
61.296875
54.8046875
20
16.75390625
17.90234375
4.33203125
1.1015625
0.4921875
0.3984375

20126D
61.8359375
52.34375
20.75
1.63671875
13.4375
0.6640625
1.4765625
0.703125
0.46875

20127B
57.5703125
52.4140625
19.3671875
1.3203125
13.578125
3.7578125
1.171875
0.609375
0.46875

20128D
64.1796875
65.0234375
24.6875
5.52734375
15.3125
11.26953125
1.5234375
0.75
0.6796875

20129B
60.3359375
52.625
19.203125
10.5078125
14.703125
3.91015625
1.5
0.46875
0.4453125

20130D
69.171875
66.3828125
22.5546875
1.58984375
23.12890625
4.8828125
1.4296875
0.5859375
0.609375

20131B
59.28125
42.2421875
18.5234375
5.48046875
14.4453125
4.07421875
1.3359375
0.328125
0.3984375

20132D
68.4921875
59.1640625
25.859375
6.01953125
21.60546875
4.77734375
1.4765625
0.5390625
0.5859375

20133B
61.765625
59.703125
17.3984375
1.90625
17.6796875
3.34765625
1.03125
0.515625
0.3984375

20134D
62.4921875
61.2734375
21.1953125
1.25
15.44140625
0.79296875
1.265625
0.7734375
0.4921875

20135B
59.4453125
50.84375
20.7265625
14.984375
16.16796875
3.359375
1.21875
0.5390625
0.5625

20136D
67.25
61.90625
23.375
2.26953125
18.5234375
5.10546875
1.9453125
0.515625
0.5390625

20137B
55.2734375
43.0625
15.21875
0.83984375
18.55859375
2.75
0.8203125
0.3046875
0.328125

20138D
56.703125
49.8828125
17.234375
1.33203125
23.1171875
2.8203125
1.1015625
0.28125
0.609375

20139B
64.53125
58.2734375
22.4140625
2.76171875
20.3046875
5.140625
1.7578125
0.609375
0.609375

20140D
67.71875
61.8828125
26.46875
2.3984375
18.8515625
5.5390625
1.640625
0.84375
0.703125

20141B
60.78125
55.0390625
20.0234375
2.50390625
19.25
4.30859375
1.2421875
0.46875
0.4453125

20142D
65.09375
58.5546875
26.328125
6.6875
28.87109375
5.8203125
1.78125
0.4921875
0.75

20144B
55.1796875
50.515625
18.875
1.47265625
16.33203125
2.69140625
0.7734375
0.3984375
0.3046875

20145D
61.625
53.28125
21.7109375
5.85546875
16.5546875
2.71484375
0.8671875
0.46875
0.3515625

20146B
62.7265625
48.8515625
21.2421875
1.484375
17.66796875
4.42578125
1.359375
0.3515625
0.4921875

20147D
63.171875
52.3203125
22.8828125
1.75390625
17.71484375
3.96875
1.5234375
0.3515625
0.46875

20148B
60.1953125
50.3984375
34.1328125
2.10546875
18.30078125
45.8515625
1.1015625
0.4453125
91.453125

20149D
63.125
48.2890625
19.625
1.56640625
14.046875
3.58203125
1.4296875
0.328125
0.3046875

20150B
57.265625
41.796875
17.46875
1.61328125
15.2890625
0.40625
1.1484375
0.234375
0.375

20151D
56.28125
49.34375
20.2109375
1.14453125
16.671875
3.83984375
1.1484375
0.328125
0.3515625

20152B
57.03125
45.21875
20.234375
1.80078125
20.76171875
4.2734375
1.1484375
0.3984375
0.5625

20153D
62.2578125
47.6328125
23.0703125
1.625
19.61328125
3.2890625
1.03125
0.3046875
0.421875

20154B
64.90625
55.1328125
22.671875
24.875
22.0625
3.6875
1.40625
0.421875
0.5625

20155D
64.4140625
52.671875
18.734375
1.9296875
19.90625
5.7265625
1.5
0.375
0.515625

20156A
59.234375
49.109375
21.171875
1.4140625
18.078125
4.82421875
1.3125
0.421875
0.7734375

20157D
60.7578125
54.875
22.0390625
2.421875
13.19140625
3.21875
1.78125
0.4921875
0.46875

20158B
61.1328125
52.3203125
19.90625
15.8984375
18.98046875
3.51171875
0.9375
0.3984375
0.5859375

20159D
62
54.453125
21.6171875
1.89453125
20.31640625
4.484375
1.3359375
0.4453125
0.515625

20160B
62.0703125
55.671875
23.703125
1.90625
17.99609375
4.8828125
1.171875
0.4921875
0.5625

20161D
55.953125
53.8203125
17.65625
1.4609375
18.640625
1.98828125
1.03125
0.375
0.3046875

Donor 20003
63.359375
54.0078125
22.3203125
2.76171875
32.38671875
4.4609375
1.4765625
0.4453125
0.796875

Donor 20004
70.3203125
64.390625
27.78125
7.14453125
24.78125
4.51953125
1.7109375
0.796875
3.8671875

Donor 20005
61.1796875
53.3515625
19.8828125
1.54296875
16.56640625
4.09765625
1.1484375
0.3515625
0.4921875

Donor 20006
66.921875
57.2890625
24.875
7.3671875
18.9921875
4.4609375
1.265625
0.65625
0.703125

Donor 20007
68.2109375
56.9140625
29.9609375
8.22265625
22.9765625
12.875
1.8984375
0.515625
1.3125

Donor 20008
60.921875
52.765625
19.53125
11.71484375
19.1328125
3.86328125
1.0546875
0.328125
0.3984375

Donor 20009
63.7578125
51.3828125
21.21875
2.05859375
19.82421875
3.6640625
1.7109375
0.3984375
0.46875

Donor 2001
63.96875
50.0703125
17.703125
17.83203125
22.05078125
3.04296875
1.7109375
0.4453125
0.2578125

Donor 20010
59.1171875
52.8359375
15.21875
22.6015625
17.046875
3.16315625
1.21875
0.375
0.4453125

Donor 20011
63.734375
55.7421875
21.4765625
3.8515625
16.00390625
4.8125
2.625
0.6796875
0.421875

Donor 20012
56.890625
57.7578125
22.25
3.0078125
17.3984375
4.5078125
1.875
0.515625
0.328125

Donor 20013
74.6328125
67.9765625
26.6328125
2.515625
18.4765625
6.41796875
2.484375
0.984375
0.6796875

Donor 20014
71.46875
63.2890625
26.0234375
1.90625
18.171875
5.703125
1.734375
0.515625
0.5625

Donor 20015
75.1015625
67.015625
32.1171875
5.33984375
23.48046875
7.96484375
2.8828125
0.9140625
1.0546875

Donor 20016
70.34375
59.0234375
25.390625
3.6640625
18.88671875
6.08984375
2.484375
0.9609375
0.7734375

Donor 20017
53.703125
49.5546875
19.71875
1.1796875
13.37890625
3.5703125
1.03125
0.3984375
0.5625

Donor 20018
61.53125
59.421875
20.8671875
2.515625
18.76953125
6.7139375
1.40625
0.4453125
0.421875

Donor 20019
63.7578125
51.921875
22.8828125
18.79296875
17.9375
2.69140625
1.1015625
0.328125
0.4453125

Donor 2002
56.796875
61.90625
20.7734375
1.73046875
13.91796875
4.25
1.4765625
0.9143625
0.609375

Donor 20020
68.046875
62.84375
26.046875
1.9765625
13.4375
2.234375
1.875
0.65625
0.796875

Donor 20021
58.8359375
56.2109375
22.71875
15.21875
16.51953125
4.61328125
1.03125
0.7734375
0.6328125

Donor 20022
63.0078125
66.3359375
23.3984375
13.71875
14.7265625
3.30078125
1.3125
0.703125
0.4921875

Donor 20023
62.9609375
55.3203125
22.6953125
2.375
15.76953125
3.62890625
1.5
0.5859375
0.6796875

Donor 20024
58.296875
47.75
17.515625
18.4765625
17.29296875
3.95703125
0.75
0.3984375
0.5859375

Donor 20025
63.453125
55.7890625
17.639375
2
16.296875
3.74609375
1.359375
0.703125
0.5859375

Donor 20026
70.90625
65
26.1640625
3.72265625
15.13671875
6.4765625
2.1796875
0.8671875
0.75

Donor 20027
59.5625
54.5234375
22.4609375
16.00390625
15.76953125
4.90625
1.0078125
0.7265625
0.65625

Donor 20028
57.5703125
52.3671875
17.2578125
1.0625
14.99609375
2.75
1.078125
0.3984375
0.421875

Donor 20029
62.8203125
57.8984375
25.8828125
16.8359375
19.12109375
4.15625
1.171875
0.7265625
0.703125

Donor 20030
58.0390625
47.8671875
17.2109375
1.54296875
17.57421875
3.40625
1.2421875
0.3515625
0.421875

Donor 20031
57.59375
54.6875
15.8515625
12.734375
17.64453125
0.828125
1.265625
0.3984375
0.375

Donor 20032
68.046875
62.4921875

19.859375
20.84375

1.3125
0.65625

Donor 20033
57.8515625
60.643625
15.453125
13.58984375
15.125
3.4296875
0.9609375
0.65625
0.28125

Donor 20034
65.84375
55.859375
23.2578125
17.29296875
17.41015625
5.1640625
1.7109375
0.7265625
0.65625

Donor 20035
62.375
62.3515625
21.546875
15.48828125
16.80078125
2.84375
1.0078125
0.4453125
0.421875

Donor 20036
64.5546875
52.390625
21.9453125
1.91796875
12.25390625
5.0234375
1.5703125
0.4921875
0.609375

Donor 20037
63.078125
60.21875
23.234375
1.3671875
17.90234375
4.37890625
1.3125
0.4921875
0.3515625

Donor 20038
54.828125
51.96875
15.078125
14.05859375
14.45703125
4.8125
1.0546875
0.4453125
0.375

Donor 20039
59
54.4296875
16.8828125
1.8828125
16.75390625
2.3515625
1.265625
0.4453125
0.28125

Donor 20040
61.9296875
55.8828125
17.9609375
2.3984375
14.97265625
3.1484375
1.21875
0.6328125
0.515625

Donor 20041
69.546875
63.546875
22.0390625
3.5234375
17.36328125
4.44921875
1.78125
0.6328125
0.7265625

Donor 20042
60.7109375
49.6953125
19.53125
2.0703125
15.67578125
0.88671875
1.078125
0.3515625
0.5390625

Donor 20043
60.453125
58.4140625
19.765625
1.16796875
15.546875
4.70703125
1.1484375
0.515625
0.3984375

Donor 20044
54.8046875
43.2265625
18.1015625
12.7109375
15.60546875
70.47265625
0.9375
0.4453125
15.0703125

Donor 20045
57.8515625
55.34375
18.078125
12.6875
19.28515625
5.09375
0.890625
0.3984375
0.5625

Donor 20046
60.6875
55.7421875
21.03125
1.49609375
20.85546875
25.859375
1.1015625
0.4921875
4.640625

Donor 20047
67.9765625
59.84375
21.078125
9.55859375
17.31640625
3.6640625
1.3359375
0.4921875
0.375

Donor 20048
57.125
50.984375
15.921875
3.65234375
15.6758125
2.38671875
0.9140625
0.3984375
0.3515625

Donor 20049
65.984375
62.234375
22.2265265
1.5546875
17.0234375
4.51953125
1.3125
0.515625
0.5859375

Donor 20050
67.4140625
55.859375
27.9453125
3.20703125
18.8984375
5.75
1.7578125
0.46875
0.84375

Donor 20051
67.953125
57.875
23.140625
2.796875
12.7109375
4.390625
2.34375
0.46875
0.5625

Donor 20052
60.9453125
55.109375
17.3984375
1.82421875
21.5703125
2.48046875
1.1484375
0.375
0.3984375

Donor 20053
76.296875
71.3046875
31.3203125
12.93359375
21.21875
6.79296875
1.8984375
0.84375
0.8671875

Donor 20054
60.9921875
54.921875
20.2578125
1.58984375
19.015625
1.05078125
1.3359375
0.46875
0.9140625

Donor 20055
65.84375
58.53125
0.21875
2.45703125
17.22265625
0.171875
1.8515625
0.4453125
0.046875

Donor 20056
61.53125
53.5390625
18.265625
1.5078125
14.703125
3.27734375
1.078125
0.5625
0.3515625

Donor 20057
60.171875
55.8125
15.3125
2.10546875
19.58984375
2.375
1.2421875
0.3984375
0.234375

Donor 20058
59.796875
46.4609375
16.3671875
1.8125
15.5
6.41796875
0.9375
0.28125
0.3046875

Donor 20059
56.09375
49.1328125
13.7890625
1.765625
19.2265625
2.71484375
1.125
0.28125
0.2109375

Donor 20060
66.3359375
57.5703125
27.2421875
7.14453125
17.31640625
5.2578125
1.6171875
0.6796875
0.890625

Donor 20061
65.8671875
54.5234375
21.6640625
2.328125
12.16015625
3.8984375
1.40625
0.3984375
0.46875

Donor 20062
66.734375
60.3125
22.5078125
16.109375
18.37109375
3.96875
1.5
0.6328125
0.703125

Donor 20063
53.3984375
47.1640625
15.453125
1.34375
12.2421875
3.06640625
0.984375
0.28125
0.2578125

CRT dA
CN dA
CFF dA

Integration
Integration
Integration

to Acrit
to Acrit
to Acrit

Patient ID
CRT LY30
CN LY30
CFF LY30
CRT CL30
CN CL30
CFF C130
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

20064
0.024833187
0.032159975
9.17E-04
0.945202052
0.930819316
0.998963014
22.01000977
123.6604614
13.46868896

20066
0.027227931
0.031155364
3.31533656
0.935930925
0.931338818
0.966231427
9.047241211
79.45422363
7.499816895

20067
0.057821358
0.036387622
−0.003856145
0.875837515
0.912442997
0.998925116
153.9547119
99.68444824
9.722900391

20068
0.028914749
0.022136074
0.014169329
0.942663379
0.943586865
0.969329073
10.61444092
73.97808838
16.71514893

20069
0.010409081
0.021366745
0.006801809
0.976786527
0.951659801
0.989883507
45.56744385
124.6541748
40.34179687

20070
0.02001886
0.01853278
0.021710115
0.954102921
0.954418734
0.959705373
177.7263794
85.78564453
12.21624756

20072B
0.032224503
0.015311278
0.026953188
0.932561583
0.955997392
0.947699758
15.43798828
37.31286621
7.895324707

20073D
0.031841081
0.023220757
0.009871479
0.929929013
0.94563859
0.988099531
289.40625
91.93579102
19.81658936

20074B
0.02866456
0.026303772
0.019107598
0.944695397
0.939642621
0.966643502
48.4118042
70.91455078
22.12207031

20075D
0.039951448
0.042670895
0.00504913
0.91142793
0.900385524
0.982697853
257.40802
91.57983398
22.74169922

20076B
0.043616073
0.01924223
0.02673753
0.917068718
0.951116476
0.950975942
48.6293335
54.76135254
6.827453613

20077D
0.04500375
0.009964381
0.014003905
0.931991849
0.969971595
0.979778527
136.005249
63.19555664
6.870300293

20078B
0.059638955
0.0397574
0.0332274142
0.883989428
0.90965251
0.935842601
8.946716309
65.0725708
9.99810791

20079D
0.066583796
0.051418454
0.01426999
0.872471191
0.883002925
0.969322539
76.22094727
55.92645264
11.32965088

20080B
0.049277595
0.023347729
0.020451634
0.905485951
0.944366823
0.956655395
245.0846558
83.91027832
20.39337158

20081D
0.016452223
−0.001491967
−0.00394093
0.962917182
0.988105563
1.00090799
47.89105225
83.4307251
22.50933838

20082B
0.036992942
0.028016378
0.008201792
0.922341024
0.936918896
0.984641638
5.176208496
68.65686035
9.922302246

20083B
0.014174326
0.007678877
−0.001578657
0.972196478
0.973359234
1.001045661
186.598938
67.07647705
24.83129883

20084D
0.033066897
0.02959325
0.01943336
0.926884422
0.937000406
0.959297686
140.1745605
82.28704834
9.225219727

20085D
0.041087168
0.023255641
−0.007493108
0.919830125
0.944328979
1.007089405
18.01373291
52.26830537
7.194946289

20086B
0.042433701
0.033799237
3.81E−04
0.920943657
0.927684758
0.994857731
17.7088623
62.7522583
22.92791748

20087D
0.022928927
0.017378819
−0.005552389
0.954458563
0.956338706
1.004885993
270.4449463
118.2469482
20.77075195

20088B
0.021815134
0.008897823
0.010444395
0.956643002
0.971822969
0.978704525
140.0905151
79.40148926
8.343566895

20090B
0.059329015
0.044530954
0.013343385
0.883988619
0.898667493
0.970599322
61.87060547
69.78076172
17.21282959

20091D
0.025758288
0.01940219
−0.007108577
0.942158476
0.952688439
1.004993342
23.20477295
110.65979
17.00518799

20092B
0.022125789
0.022683333
0.011923631
0.949278629
0.947741935
0.976224784
216.5800781
97.90631104
13.76202393

20093D
0.024585153
0.016145642
−0.009099425
0.94628821
0.957420776
1.012011087
367.4399414
79.46740723
33.99719238

20094B
0.014574856
0.012071477
0.009293042
0.965892772
0.969758836
0.987714073
31.93560791
106.9568481
10.24035645

20095D
0.027034079
0.008573037
−0.013358404
0.940491293
0.971485743
1.013734467
225.9354858
68.21191406
14.21026611

200961B
0.021996402
0.01234881
0.021483583
0.953874092
0.962285714
0.956222132
64.88140869
38.86523438
6.565429687

20097D
0.023692686
0.018750939
−0.004599629
0.949033517
0.959112413
1.005751534
171.539978
155.7394409
11.30657959

20098B
0.026020912
0.019252464
0.026261418
0.939470366
0.954015193
0.947803393
14.31903076
86.23718262
12.51617432

20099D
0.024551547
0.026462046
−0.013231336
0.941184316
0.943903081
1.002549936
102.4249878
61.70910645
5.507446289

201001B
0.040584392
0.078264405
0.032046362
0.915829888
0.853393196
0.933732684
13.95648193
77.07623291
60.44018555

20101D
0.03119636
0.027867496
0.009337058
0.933238453
0.933343143
0.98013245
12.74194336
72.55755615
14.88262939

201021B
0.03191815
0.032849106
−0.008873434
0.930960209
0.932446264
1.047819549
91.86328125
96.72802734
33.78460693

20103D
0.038131123
0.026895376
−0.007834213
0.922488965
0.93931732
1.020844914
201.2475586
169.8640137
34.12243652

201041B
0.035729727
0.014632895
0.007350707
0.926838016
0.969568893
0.993164341
198.9783325
154.1293945
34.80633545

20105D
0.044985779
0.024768064
−0.015139172
0.91278621
0.944054964
1.02688391
10.42987061
72.78662109
8.246337891

201061B
0.048066538
0.030807178
0.020493357
0.911639166
0.929827175
0.968201391
23.42230225
76.59503174
12.2244873

20108B
0.04610737
0.055939588
0.008846676
0.897693079
0.880924468
0.987056568
137.7454834
62.3303833
6.303405762

20109D
0.032723807
0.02958799
0.00963191
0.929873068
0.934539649
0.983839938
18.49822998
101.1774902
23.00372314

201101B
0.041664932
0.037481321
0.005831413
0.916296502
0.922748893
1.020737327
7.199890137
59.24377441
7.386108398

20111D
0.07380315
0.035058589
0.01398226
0.864779076
0.917244306
1.001260504
11.9262085
72.05822754
18.81628418

20112B
0.037126394
0.019984526
0.014676904
0.923516976
0.952426132
0.95193008
18.40759277
82.00195313
16.73822021

20113D
0.062763232
0.03286058
0.004612521
0.875330291
0.921362543
0.987467866
237.548584
95.33221436
17.81433105

201141B
0.024689651
0.02696704
0.001779683
0.944137094
0.937761194
0.99766173
108.7250977
63.23675537
14.72607422

20115B
0.026801432
0.019098248
0.010429078
0.937839545
0.957028943
0.974468085
14.66674805
84.22009277
12.0135498

20116D
0.041788659
0.012975699
0.012377694
0.909358289
0.957083906
0.970249901
18.28729248
61.83599854
10.85668945

201171B
0.036011244
0.027881581
0.035371179
0.924625208
0.941667933
0.929257642
121.7373047
69.22869873
10.15301514

20118D
0.020317437
0.023174715
0.007876845
0.95283237
0.951180717
0.987412587
61.04168701
121.1506348
17.87860107

20119B
0.02381942
0.007657879
0.021167605
0.952802704
0.974248927
0.955665025
174.1404419
97.82391357
15.67858887

20120D
0.040758131
0.023425042
0.010314535
0.918711478
0.945497321
0.980459376
222.6000366
91.41998291
29.78997803

20121B
0.031288949
0.032133624
0.009660442
0.924949563
0.926094891
0.98111624
136.7023315
108.9755859
13.52471924

20122D
0.035321697
0.027525692
−0.00513424
0.930216878
0.938090502
1.006276151
224.470459
72.49328613
22.86859131

20123B
0.033839427
0.088742387
0.008031119
0.9260297
0.828109899
0.987073609
15.44128418
58.38848877
19.63201904

20124D
0.055306995
0.057727962
0.02311456
0.892009191
0.893894922
0.948391922
25.14276123
102.321167
27.14172363

20125B
0.048024825
0.026111309
0.041437174
0.907468774
0.939272986
0.914453125
185.3300171
70.58001709
9.764099121

20126D
0.033167509
0.109710199
0.005837412
0.930638029
0.806567164
0.980798193
16.9821167
76.05615234
2.073120117

20127B
0.04030228
0.053709983
0.020658532
0.917356493
0.890892831
0.957644211
10.63256836
71.53088379
12.26733398

20128D
0.044331507
0.023482618
0.011477672
0.908703591
0.94196804
0.979113924
77.29376221
87.25891113
62.69952393

20129B
0 .034457501
0.028807898
0.023877814
0.930078985
0.933194774
0.95362083
142.3498535
57.01574707
13.45880127

20130D
0.023212202
0.007788533
6.96E−04
0.946803705
0.973520066
0.991686872
15.94061279
121.3665161
26.18920898

20131B
0.043807474
0.03083657
−0.006430128
0.91341592
0.92454226
1.003795867
55.03985596
35.0255127
11.60980225

20132D
0.042476997
0.025035029
0.005946626
0.915478499
0.94810511
0.985498489
82.80780029
70.1350708
23.00372314

20133B
0.012985918
−7.23E−04
−0.008082622
0.969643309
0.989008113
1.01077683
16.52893066
82.35131836
12.51617432

20134D
0.039836577
0.026127863
0.014341442
0.926115764
0.938416422
0.969037965
9.996459961
67.71917725
2.796569824

20135B
0.035194616
0.059814843
0.020118734
0.925877251
0.887523049
0.959291368
182.315918
75.27008057
17.15844727

20136D
0.022431653
0.022472166
0.01052529
0.951208178
0.953054013
0.979946524
33.27044678
85.70654297
25.14935303

20137B
0.037332155
0.030097212
0.024850274
0.921978799
0.931966618
0.947638604
4.075378418
52.4196167
6.858764648

20138D
0.047406693
0.023399896
0.005910018
0.901625792
0.938919342
0.985040798
10.56170654
57.3684082
9.422973633

20139B
0.041498688
0.031996581
0.017536114
0.912106538
0.922375654
0.968630185
39.67437744
95.60412598
27.92944336

20140D
0.527082853
1
1
0.951892017
1
1
31.40002441
142.3432617
32.80407715

20141B
0.047614967
0.032637805
0.027701912
0.904755784
0.925904897
0.939133828
28.31011963
79.32568359
17.22271729

20142D
0.022763142
0.033247165
−0.006142433
0.940590494
0.923549033
1.008902077
105.5742188
104.3069458
30.98803711

20144B
0.016424796
0.024664914
0.00211955
0.96092312
0.939220538
0.988824503
9.5 0314941
59.581604
8.468811035

20145D
0.029375317
0.029634449
−0.016528727
0.93724645
0.93797654
1.0215905
43.99200439
69.5994873
5.809020996

20146B
0.027744219
0.029046058
0.002625046
0.924523602
0.932832241
0.994483266
13.85925293
54.21258545
19.41119385

20147D
0.047133935
0.033383522
0.021421797
0.902052931
0.92160669
0.961078867
19.40130615
37.47930908
16.64099121

20148B
0.032600404
0.044176398
−0.343559739
0.9330305
0.904200899
0.003662165
20.50213623
66.52935791
105.208374

20149D
0.025634798
0.029747074
−0.008754644
0.946534653
0.929623038
1.00955414
15.53192139
31.12646484
9.361999512

20150B
0.037720365
0.054626687
0.027442979
0.922646658
0.894579439
0.939624329
14.42779541
21.01464844
0.685546875

20151D
0.04069884
0.036162788
0.015357235
0.922543032
0.919252692
0.964051024
8.215026855
44.57702637
12.90838623

20152B
0.043437785
0.035774447
0.033006757
0.909178082
0.914996545
0.929343629
16.7744751
76.15338135
22.21435547

20153D
0.029718283
0.03837133
0.001880856
0.936002008
0.924225029
0.990856756
13.03857422
54.78277588
10.1282959

20154B
0.041638581
0.039198078
0.019272149
0.914058739
0.915403146
0.964851826
318.8287354
86.66235352
18.76025391

20155D
0.029455731
0.023614407
0.016167408
0.938508187
0.944378523
0.974979149
21.53210449
61.49816895
22.1385498

20156A
0.031059307
0.040872574
−0.014663284
0.927195991
0.906458797
1.047601476
12.55407715
60.21936035
24.66815186

20157D
0.029935851
0.021280609
−0.009133877
0.934807766
0.943621868
1.012761432
35.09802246
53.40179443
10.31945801

20158B
0.038318779
0.033309691
0.023378903
0.922172524
0.926534269
0.952904239
154.956665
63.73443604
14.00262451

20159D
0.039985334
0.020185119
0.022336164
0.920236895
0.953084648
0.955547524
19.22662354
81.96734619
15.30944824

20160B
0.032691245
0.026974577
0.001812788
0.933920705
0.935587988
0.990112063
17.83410645
78.66485596
24.4720459

20161D
0.064456894
0.030047298
0.040432645
0.871404636
0.922920598
0.92300885
11.79602051
62.04528809
4.207214355

Donor 20003
0.028680127
0.027663862
0.002012601
0.938224414
0.944018516
1.002100105
36.47076416
130.2588501
31.66699219

Donor 20004
0.022439636
0.027468387
0.004736127
0.949672259
0.941397719
0.993250844
121.7158813
173.2653809
69.75274658

Donor 20005
0.029513579
0.045045639
−0.009513752
0.935257311
0.925318495
1.017681729
13.49505615
52.74261475
16.94586182

Donor 20006
0.030370554
0.042962748
0.006588498
0.933808078
0.904677485
0.996231156
93.28710938
104.8656006
26.24194336

Donor 20007
0.062782995
0.031328071
−0.007090395
0.88592372
0.927522306
1.017209909
136.1321411
100.861084
127.6237793

Donor 20008
0.03659895
0.02103815
0.00228
0.926134906
0.944477347
1
69.38360596
50.48657227
12.7633667

Donor 20009
0.038635312
0.026344331
0.012003968
0.931993628
0.939790178
0.986745214
26.43475342
68.25970459
12.85400391

Donor 2001
0.022351307
0.030189967
−0.010354148
0.949804592
0.93025433
1.014563107
198.2400513
54.50921631
6.537414551

Donor 20010
0.03470864
0.018110799
−0.006091718
0.931412713
0.952979447
1.009240246
205.680542
57.43432617
6.77142334

Donor 20011
0.024335519
0.019395001
−0.015828483
0.959181172
0.955430974
1.036013096
85.6307373
90.99481201
17.77807617

Donor 20012
0.027107937
0.026588214
0.026460089
0.939851689
0.939131611
0.947331461
46.95666504
66.31347656
14.10644531

Donor 20013
0.015684863
0.022569085
0.017489244
0.959803203
0.953108838
0.965679085
43.54870605
145.6160889
37.48260498

Donor 20014
0.041661201
0.025575032
0.007622836
0.912439878
0.940748056
0.985589913
23.54919434
83.30383301
20.16101074

Donor 20015
0.041298242
0.045100839
−0.002598719
0.920108187
0.915364887
1.011675991
137.0714722
186.5791626
61.12738037

Donor 20016
0.024066927
0.022948379
0.009179487
0.951688139
0.944407677
0.981538462
72.82287598
161.2765503
35.73248291

Donor 20017
0.061507734
0.03284789
.009612168
0.876927553
0.922907142
0.983359746
8.26940918
47.06707764
18.23291016

Donor 20018
0.018540503
0.013432926
6.21E−04
0.948958862
0.961740731
0.991014601
31.47253418
74.39666748
26.77258301

Donor 20019
0.016830896
0.001863276
0.010319222
0.963607401
0.980138429
0.981563674
203.8925171
49.21105957
9.816833496

Donor 2002
0.019869899
0.022142472
−0.001980694
0.954195323
0.952675416
1
18.73553467
102.4777222
24.4720459

Donor 20020
0.034770379
0.022890249
0.005045241
0.923536165
0.945176529
0.982903419
25.84313965
71.97912598
9.452636719

Donor 20021
0.040136879
0.03418404
0.004191025
0.911963883
0.918276581
0.992778542
146.1335449
111.3305054
27.13677979

Donor 20022
0.02218158
0.012441605
−0.00942404
0.956106634
0.968201625
1.012020033
169.1784668
89.15075684
14.34869385

Donor 20023
0.029469641
0.026219814
0.004001721
0.93634446
0.935602316
0.991738382
29.16210937
83.44390869
20.65704346

Donor 20024
0.052116278
0.047406741
0.024062717
0.890645939
0.892015707
0.961195361
133.9 23535
61.14385986
19.03216553

Donor 20025
0.018108054
0.024227855
9.74E−04
0.963432652
0.9453858
1.00931677
21.20251465
101.0687256
17.54901123

Donor 20026
0.029490629
0.033851162
3.04E−04
0.933891582
0.922115385
0.99820842
71.36773682
106.2877808
40.62194824

Donor 20027
0.040186145
0.061528036
0.030110145
0.917759706
0.895543774
0.937391304
156.7545776
100.9484253
31.09680176

Donor 20028
0.04236228
0.023107812
−0.008904859
0.928755598
0.942264658
1.014938886
7.016967773
48.56341553
8.37487793

Donor 20029
0.044844132
0.040235236
0.018316732
0.905981843
0.908514371
0.95834591
201.1849365
127.664978
23.58874512

Donor 20030
0.043891431
0.030500925
0.001550915
0.910755149
0.92704423
1.019064911
14.37835693
54.49603271
11.3939209

Donor 20031
0.014741025
−0.006701786
−0.01510391
0.962154097
0.995285714
1.019221291
110.5444336
62.43585205
1.911621094

Donor 20032
0.049918197
0.035924629

0.890815155
0.919364921

277.6662598
120.2178955

Donor 20033
0.031890427
0.096808526
0.049121587
0.93923025
0.819118784
0.925682508
117.9585571
65.63781738
9.043945313

Donor 20034
0.047260619
0.089839161
0.014281715
0.905671571
0.817062937
0.973799127
255.2492065
116.1359253
32.17785645

Donor 20035
0.019283358
−0.005776741
−0.009875816
0.955661323
0.996616965
1.011965192
144.1444702
61.64154053
9.44934082

Donor 20036
0.047403418
0.038066657
0.011970452
0.904877163
0.909633164
0.974368103
22.27532959
49.19952393
27.2109375

Donor 20037
0.058277943
0.028034546
0.018986307
0.889645777
0.942786715
0.96267653
11.84216309
80.40838623
14.2366333

Donor 20038
0.042141636
0.0278638
0.036417674
0.910230835
0.935057126
0.928497409
121.1358032
55.23760986
14.70629883

Donor 20039
0.041930762
0.023091598
−0.008177156
0.916181144
0.947036027
1.006941231
19.96325684
64.29473877
5.260253906

Donor 20040
0.027842956
0.110195606
0.0128806
0.942475085
0.823850133
0.972596781
25.91564941
84.21844482
11.01489258

Donor 20041
0.023519527
0.046152809
0.005627437
0.949786565
0.920334399
0.987238568
50.97766113
94.82794189
24.20013428

Donor 20042
0.031860264
0.006529372
0.022183333
0.935529533
0.97264581
0.9568
19.70288086
50.45526123
3.640319824

Donor 20043
0.028967433
0.025334916
−0.011353755
0.930214526
0.939414204
1.018972332
8.505065918
65.78942871
11.39227295

Donor 20044
0.114197553
0.158564522
0.025780463
0.788310763
0.718055305
0.948208891
36.30432129
52.46905518
297.8486938

Donor 20045
0.064360605
0.026431042
0.009035581
0.875219446
0.93393563
0.979256698
109.1832275
68.46405029
18.89208984

Donor 20046
0.032919778
0.024525812
0.003056897
0.929325438
0.938612474
0.989970282
12.31842041
83.62518311
52.18725586

Donor 20047
0.024480903
0.020561902
−0.009360329
0.945523503
0.946344648
1.010007413
105.4539185
64.4331665
10.7578125

Donor 20048
0.031785649
0.03008713
0.025537019
0.931892779
0.937480846
0.955839058
25.76898193
46.86273193
4.401672363

Donor 20049
0.020950088
0.005545443
0.003060926
0.958797064
0.977403967
0.989455185
14.84802246
76.41870117
25.08013916

Donor 20050
0.028353356
0.025734848
0.00905787
0.9426353
0.938741259
0.978194017
48.99188232
78.01721191
42.89941406

Donor 20051
0.04621832
0.0282808
−7.22E−04
0.908254771
0.933180346
0.994935854
50.53601074
44.65283203
23.11743164

Donor 20052
0.023606482
0.018178811
0.007644814
0.946545315
0.95151687
0.981140548
16.95574951
74.86303711
7.892028809

Donor 20053
0.028782681
0.025034087
0.008367285
0.943170182
0.947737482
0.989523572
252.0686646
150.3588867
48.98529053

Donor 20054
0.019195202
0.021942864
0.003445173
0.958883054
0.946230441
0.995372156
15.55169678
77.12072754
6.395690918

Donor 20055
0.016911387
0.006258898
0.355654762
0.959776934
0.975173518
0.571428571
35.99285889
65.85040283
0.009887695

Donor 20056
0.033615837
0.032245002
0.038925126
0.927628238
0.928206625
0.926860565
12.4354248
69.6159668
9.968444824

Donor 20057
0.023619226
−0.001850037
0.007844388
0.953648403
0.98656215
0.975510204
21.93255615
69.59454346
4.726318359

Donor 20058
0.037410178
0.021196962
0.009401352
0.919649856
0.942492013
0.978520286
14.59753418
35.77038574
8.762145996

Donor 20059
0.035590761
0.012877644
0.026754013
0.924791086
0.959453013
0.947308782
16.30810547
50.58544922
5.380554199

Donor 20060
0.039458937
0.027774951
0.004994742
0.916617595
0.937712037
0.989675939
84.71942139
89.47869873
40.0715332

Donor 20061
0.026452477
0.005382218
0.00186621
0.941999763
0.975497922
0.991345114
27.33288574
38.02313232
16.60803223

Donor 20062
0.037482927
0.023038104
0.01319565
0.922383517
0.944430052
0.975008678
244.914917
101.2318726
24.81811523

Donor 20063
0.037364667
0.016231848
0.011351955
0.918800293
0.948318701
0.975733064
9.897583008
26.38366699
6.593444824

TABLE 3

Patient ID
CRT Amax (mm)
CN Amax (mm)
CFF Amax (mm)
CRT Acrit (mm)
CN Arit (mm)
CFF Acrit (mm)
CRT dAmax (mm)
CN dAmax (mm)
CFF dAmax (mm)
CRT LY30

20150B
57.265625
41.796875
17.46875
1.61328125
15.2890625
0.40625
1.1484375
0.234375
0.375
0.037720365

20131B
59.28125
42.2421875
18.5234375
5.48046875
14.4453125
4.07421875
1.3359375
0.328125
0.3984375
0.043807474

20137B
55.2734375
43.0625
15.21875
0.83984375
18.55859375
2.75
0.8203125
0.3046875
0.328125
0.037332155

Donor 20044
54.8046875
43.2265625
18.1015625
12.7109375
15.60546875
70.47265625
0.9375
0.4453125
15.0703125
0.114197553

20152B
57.03125
45.21875
20.234375
1.80078125
20.76171875
4.2734375
1.1484375
0.3984375
0.5625
0.043437785

20100B
52.90625
45.2421875
20.8671875
1.49609375
15.91015625
3.1015625
1.3359375
0.5390625
2.203125
0.040584392

Donor 20058
59.796875
46.4609375
16.3671875
1.8125
15.5
6.41796875
0.9375
0.28125
0.3046875
0.037410178

20108B
54.5234375
46.6484375
16.296875
15.9453125
15.53515625
2.73828125
0.84375
0.4453125
0.2578125
0.04610737

Donor 20063
53.3984375
47.1640625
15.453125
1.34375
12.2421875
3.06640625
0.984375
0.28125
0.2578125
0.037364667

20110B
56.28125
47.6328125
16.953125
1.09765625
16.859375
2.796875
1.0078125
0.421875
0.328125
0.041664932

20153D
62.2578125
47.6328125
23.0703125
1.625
19.61328125
3.2890625
1.03125
0.3046875
0.421875
0.029718283

Donor 20024
58.296875
47.75
17.515625
18.4765625
17.29296875
3.95703125
0.75
0.3984375
0.5859375
0.052116278

Donor 20030
58.0390625
47.8671875
17.2109375
1.54296875
17.57421875
3.40625
1.2421875
0.3515625
0.421875
0.043891431

20072B
58.0390625
47.9375
16.1328125
1.71875
14.1875
3.37109375
1.125
0.328125
0.3046875
0.032224503

20079D
61.015625
48.078125
18.3359375
6.2421875
17.10546875
3.37109375
1.265625
0.3984375
0.3984375
0.066583796

20149D
63.125
48.2890625
19.625
1.56640625
14.046875
3.58203125
1.4296875
0.328125
0.3046875
0.25634798

20146B
62.7265625
48.8515625
21.2421875
1.484375
17.66796875
4.42578125
1.359375
0.3515625
0.4921875
0.027744219

20156A
59.234375
49.109375
21.171875
1.4140625
18.078125
4.82421875
1.3125
0.421875
0.7734375
0.031059307

Donor 20059
56.09375
49.1328125
13.7890625
1.765625
19.2265625
2.71484375
1.125
0.28125
0.2109375
0.35590761

20151D
56.28125
49.34375
20.2109375
1.14453125
16.671875
3.83984375
1.1484375
0.328125
0.3515625
0.04069884

Donor 20017
53.703125
49.5546875
19.71875
1.1796875
13.37890625
3.5703125
1.03125
0.3984375
0.5625
0.061507734

Donor 20042
60.7109375
49.6953125
19.53125
2.0703125
15.67578125
0.88671875
1.078125
0.3515625
0.5390625
0.031860264

20138D
56.703125
49.8828125
17.234375
1.33203125
23.1171875
2.8203125
1.1015625
0.28125
0.609375
0.047406693

Donor 2001
63.96875
50.0703125
17.703125
17.83203125
22.05078125
3.04296875
1.7109375
0.4453125
0.2578125
0.02235107

20148B
60.1953125
50.3984375
34.1328125
2.10546875
18.30078125
45.8515625
1.1015625
0.4453125
91.453125
0.032600404

20090B
60.40625
50.421875
20.7265625
6.03125
18.5703125
4.16796875
1.078125
0.46875
0.4921875
0.059329015

20144B
55.1796875
50.515625
18.875
1.47265625
16.33203125
2.69140625
0.7734375
0.3984375
0.3046875
0.016424796

20078B
56.1640625
50.5859375
18.265625
1.21484375
15.83984375
3.62890625
1.1015625
0.4921875
0.3046875
0.059638995

20135B
59.4453125
50.84375
20.7265625
14.984375
16.16796875
3.359375
1.21875
0.5390625
0.5625
0.035194616

Donor 20048
57.125
50.984375
15.921875
3.65234375
15.67578125
2.38671875
0.9140625
0.3984375
0.3515625
0.031785649

Donor 20009
63.7578125
51.3828125
21.21875
2.05859375
19.82421875
3.6640625
1.7109375
0.3984375
0.46875
0.038635312

20117B
56.28125
51.4296875
17.890625
12.125
18.55859375
2.92578125
0.984375
0.3984375
0.3984375
0.036011244

20076B
59.9140625
51.78125
17.2109375
5.45703125
16.2734375
2.24609375
1.0546875
0.375
0.3515625
0.04316073

Donor 20019
63.7578125
51.921875
22.8828125
18.79296875
17.9375
2.69140625
1.1015625
0.328125
0.4453125
0.016830896

Donor 20038
54.828125
51.96875
15.078125
14.05859375
14.45703125
4.8125
1.0546875
0.4453125
0.375
0.042141636

20066
57.40625
52.2265625
17.3515625
1.25
17.84375
2.29296875
0.984375
0.46875
0.3515625
0.027227931

20147D
63.171875
52.3203125
22.8828125
1.75390625
17.71484375
3.96875
1.5234375
0.3515625
0.46875
0.047133935

20158B
61.1328125
52.3203125
19.90625
15.8984375
18.98046875
3.51171875
0.9375
0.3984375
0.5859375
0.038318779

20114B
57.8984375
52.34375
20.046875
11.75
17.17578125
3.546875
0.890625
0.4453125
0.46875
0.024689651

20126D
61.8359375
52.34375
20.75
1.63671875
13.4375
0.6640625
1.4765625
0.703125
0.46875
0.033167509

Donor 20028
57.5703125
52.3671875
17.2578125
1.0625
14.99609375
2.75
1.078125
0.3984375
0.421875
0.04206228

Donor 20036
64.5546875
52.390625
21.9453125
1.91796875
12.25390625
5.0234375
1.5703125
0.4921875
0.609375
0.047403418

20127B
57.5703125
52.4140625
19.3671875
1.3203125
13.578125
3.7578125
1.171875
0.609375
0.46875
0.0403228

20106B
62.046875
52.4375
23.5859375
1.89453125
14.57421875
5.375
1.7578125
0.6328125
0.375
0.048066538

20085D
62.5390625
52.625
19.8359375
1.73046875
14.45703125
4.109375
1.3828125
0.4921875
0.28125
0.041087168

20129B
60.3359375
52.625
19.203125
10.5078125
14.703125
3.91015625
1.5
0.46875
0.4453125
0.034457501

20155D
64.4140625
52.671875
18.734375
1.9296875
19.90625
5.7265625
1.5
0.375
0.515625
0.029455731

Donor 20008
60.921875
52.765625
19.53125
11.7148375
19.1328125
3.86328125
1.0546875
0.328125
0.3984375
0.03659895

Donor 20010
59.1171875
52.8359375
15.21875
22.6015625
17.046875
3.16015625
1.21875
0.375
0.4453125
0.03470864

20115B
61.8359375
52.90625
18.359375
1.5546875
22.4375
3.40625
1.265625
0.421875
0.375
0.026801432

20101D
60.3828125
53.09375
18.875
1.4140625
16.44921875
3.76953125
1.359375
0.4921875
0.4453125
0.03119636

20124D
61.203125
53.234375
20.890625
2.08203125
18.3828125
9.59375
1.4765625
0.609375
0.375
0.055306995

20145D
61.625
53.28125
21.7109375
5.85546875
16.5546875
2.71484375
0.8671875
0.46875
0.3515625
0.029375317

Donor 20005
61.1796875
53.3515625
19.8828125
1.54296875
16.56640625
4.09765625
1.1484375
0.3515625
0.4921875
0.029513579

Donor 20056
61.53125
53.5390625
18.265625
1.5078125
14.703125
3.27734375
1.078125
0.5625
0.3515625
0.033615837

20161D
55.953125
53.8203125
17.65625
1.4609375
18.640625
1.98828125
1.03125
0.375
0.3046875
0.064456894

Donor 20003
63.359375
54.0078125
22.3203125
2.76171875
32.38671875
4.4609375
1.4765625
0.4453125
0.796875
0.028680127

20086B
62.2578125
54.125
22.7890625
1.859375
14.87890625
4.70703125
1.171875
0.4921875
0.5390625
0.042433701

Donor 20039
59
54.4296875
16.8828125
1.8828125
16.75390625
2.3515625
1.265625
0.4453125
0.28125
0.041930762

20159D
62
54.453125
21.6171875
1.89453125
20.31640625
4.484375
1.3359375
0.4453125
0.515625
0.039985334

Donor 20027
59.5625
54.5234375
22.4609375
16.00390625
15.76953125
4.90625
1.0078125
0.7265625
0.65625
0.040186145

Donor 20061
65.8671875
54.5234375
21.6640625
2.328125
12.16015625
3.8984375
1.40625
0.3984375
0.46875
0.026452477

20082B
55.53125
54.6171875
18.3125
0.93359375
14.5859375
3.06640625
0.9140625
0.515625
0.3515625
0.036992942

20096B
64.53125
54.6875
19.2734375
5.59765625
13.7421875
3.6875
1.1953125
0.421875
0.1875
0.021996402

Donor 20031
57.59375
54.6875
15.8515625
12.734375
17.64453125
0.828125
1.265625
0.3984375
0.375
0.014741025

20125B
61.296875
54.8046875
20
16.75390625
17.90234375
4.33203125
1.1015625
0.4921875
0.3984375
0.048024825

20157D
60.7578125
54.875
22.0390625
2.421875
13.19140625
3.21875
1.78125
0.4921875
0.46875
0.029935851

20088B
61.625
54.8984375
17.609375
19.33203125
19.8359375
2.99609375
0.9140625
0.421875
0.3046875
0.021815134

Donor 20054
60.9921875
54.921875
20.2578125
1.58984375
19.015625
1.05078125
1.3359375
0.46875
0.9140625
0.019195202

20141B
60.78125
55.0390625
20.0234375
2.50390625
19.25
4.30859375
1.2421875
0.46875
0.4453125
0.047614967

Donor 20052
60.9453125
55.109375
17.3984375
1.82421875
21.5703125
2.48046875
1.1484375
0.375
0.3984375
0.023606482

20154B
64.90625
55.1328125
22.671875
24.875
22.0625
3.6875
1.40625
0.421875
0.5625
0.041638581

20111D
61.53125
55.2265625
18.59375
1.37890625
16.484375
5.3046875
1.2890625
0.5 5625
0.46875
0.07380315

Donor 20023
62.9609375
55.3203125
22.6953125
2.375
15.76953125
3.62890625
1.5
0.5859375
0.6796875
0.029469641

Donor 20045
57.8515625
55.34375
18.078125
12.6875
19.28515625
5.09375
0.890625
0.3984375
0.5625
0.064360605

20068
63.359375
55.671875
24.453125
1.37890625
14.97265625
4.49609375
1.0546875
0.5859375
0.6328125
0.028914749

20160B
62.0703125
55.671875
23.703125
1.90625
17.99609375
4.8828125
1.171875
0.4921875
0.5625
0.032691245

20105D
60.734375
55.71875
19.1796875
1.26171875
22.0625
4.1796875
1.3359375
0.375
0.234375
0.044985779

Donor 20011
63.734375
55.7421875
21.4765625
3.8515625
16.00390625
4.8125
2.625
0.6796875
0.421875
0.024335519

Donor 20046
60.6875
55.7421875
21.03125
1.49609375
20.85546875
25.859375
1.1015625
0.4921875
4.640625
0.032919778

Donor 20025
63.453125
55.7890625
17.609375
2
16.296875
3.74609375
1.359375
0.703125
0.5859375
0.018108054

Donor 20057
60.171875
55.8125
15.3125
2.10546875
19.58984375
2.375
1.2421875
0.3984375
0.234375
0.023619226

Donor 20034
65.84375
55.859375
23.2578125
17.29296875
17.41015625
5.1640625
1.7109375
0.7265625
0.65625
0.047260619

Donor 20050
67.4140625
55.859375
27.9453125
3.20703125
18.8984375
5.75
1.7578125
0.46875
0.84375
0.028353356

Donor 20040
61.9296875
55.8828125
17.9609375
2.3984375
14.97265625
3.1484375
1.21875
0.6328125
0.515625
0.027842956

20070
61.7890625
56.046875
18.03125
14.01171875
17.6328125
3.58203125
1.1953125
0.5625
0.3984375
0.02001886

Donor 20021
58.8359375
56.2109375
22.71875
15.21875
16.51953125
4.61328125
1.03125
0.7734375
0.6328125
0.040136879

20083B
67.4375
56.3046875
22.4140625
17.10546875
21.06640625
4.6953125
1.2890625
0.3984375
0.609375
0.014174326

20123B
55.765625
56.5859375
21.7578125
1.578125
17.22265625
5.01171875
1.359375
0.4921875
0.6796875
0.033839427

20116D
58.4375
56.796875
19.6953125
1.70703125
17.08203125
2.9375
1.4765625
0.4453125
0.421875
0.041788659

Donor 20007
68.2109375
56.9140625
29.9609375
8.22265625
22.9765625
12.875
1.8984375
0.515625
1.3125
0.062782995

Donor 20006
66.921875
57.2890625
24.875
7.3671875
18.9921875
4.46093765
1.265625
0.65625
0.703125
0.030370554

Donor 20060
66.3359375
57.5703125
27.241875
7.14453125
17.31640625
5.2578125
1.6171875
0.6796875
0.890625
0.039458937

20064
62.4453125
57.59375
22.6015625
1.9296875
16.82421875
3.60546875
1.453125
0.8203125
0.5390625
0.024833187

20098B
61.953125
57.59375
17.9609375
1.66015625
20.1875
3.39453125
1.1015625
0.515625
0.3984375
0.026020912

20112B
62.8203125
57.640625
21.453125
1.71875
21.0078125
4.49609375
1.453125
0.421875
0.4921875
0.037126394

20084D
62.1875
57.6640625
19.578125
14.3984375
19.84765625
3.21875
1.078125
0.4453125
0.328125
0.033066897

20077D
61.34375
57.7578125
16.2265625
15.8515625
14.0234375
2.52734375
1.03125
0.515625
0.3515625
0.04530375

Donor 20012
56.890625
57.7578125
22.25
3.0078125
17.3984375
4.5078125
1.875
0.515625
0.328125
0.027107937

Donor 20051
67.953125
57.875
23.140625
2.796875
12.7109375
4.393625
2.34375
0.46875
0.5625
0.04621832

Donor 20029
62.8203125
57.8984375
25.8828125
16.8359375
19.12109375
4.15625
1.171875
0.7265625
0.703125
0.044844132

20139B
64.53125
58.2734375
22.4140625
2.76171875
20.3046875
5.140625
1.7578125
0.609375
0.609375
0.041498688

Donor 20043
60.453125
58.4140625
19.765625
1.16796875
15.546875
4.70703125
1.1484375
0.515625
0.3984375
0.028967433

Donor 20055
65.84375
58.53125
0.21875
2.45703125
17.22265625
0.171875
1.8515625
0.4453125
0.046875
0.016911387

20142D
65.09375
58.5546875
26.328125
6.6875
28.87109375
5.8203125
1.78125
0.4921875
0.75
0.022763142

20109D
62.1640625
58.71875
20.3346875
1.70703125
18.78125
4.68359375
1.5234375
0.609375
0.5390625
0.032723807

20074B
63.9921875
59.0234375
22.484375
5.33984375
13.6484375
3.8046875
1.1953125
0.65625
0.65625
0.028666456

Donor 20016
70.34375
59.0234375
25.390625
3.6640625
18.88671875
6.08984375
2.484375
0.9609375
0.7734375
0.024066927

20132D
68.4921875
59.1640625
25.859375
6.01953125
21.60546875
4.77734375
1.4765625
0.5393625
0.5859375
0.042476997

20099D
58.578125
59.328125
18.3828125
13.42578125
12.6875
3.546875
0.8203125
0.5625
0.1875
0.024551547

Donor 20018
61.53125
59.421875
20.8671875
2.515625
18.76953125
6.7109375
1.40625
0.4453125
0.421875
0.018540503

20133B
61.765625
59.703125
17.3984375
1.90625
17.6796875
3.34765625
1.03125
0.515625
0.3984375
0.012985918

20120D
67.1796875
59.7734375
22.7890625
14.48046875
17.64453125
5.19921875
1.4296875
0.5859375
0.6328125
0.040758131

Donor 20047
67.9765625
59.84375
21.078125
9.55859375
17.31640625
3.6640625
1.3359375
0.4921875
0.375
0.024480903

20121B
58.0859375
59.9375
18.6171875
13.30859375
14.3984375
3.08984375
1.1015625
0.890625
0.5390625
0.031288949

20067
59.2578125
59.9639375
21.8046875
16.15625
12.78125
2.609375
0.984375
0.890625
0.375
0.057821358

Donor 20037
63.078125
60.21875
23.234375
1.3671875
17.90234375
4.37890625
1.3125
0.4921875
0.3515625
0.058277943

Donor 20062
66.734375
60.3125
22.5078125
16.109375
18.37109375
3.96875
1.5
0.6328125
0.703125
0.037482927

20092B
69.3125
60.546875
21.6875
14.6328125
18.81640625
4.33203125
1.640625
0.6328125
0.3515625
0.022125789

Donor 20033
57.8515625
60.640625
15.453125
13.58984375
15.125
3.4296875
0.9609375
0.65625
0.28125
0.031890427

20102B
68.9140625
61.0625
25.9765625
6.5
19.8828125
5.99609375
1.5
0.5625
0.6796875
0.03191815

20094B
65.28125
61.2265625
20.984375
2.57421875
16.94140625
2.8203125
1.4765625
0.7265625
0.46875
0.014574856

20134D
62.4921875
61.2734375
21.1953125
1.25
15.44140625
0.79296875
1.265625
0.7734375
0.4921875
0.039836577

20080B
64.2265625
61.5078125
25.4140625
18.60546875
18.640625
4.63671875
1.2421875
0.65625
0.4921875
0.049277595

20113D
65.046875
61.6953125
24.3125
16.2734375
18.53515625
3.7578125
1.5
0.6328125
0.515625
0.062763232

20140D
67.71875
61.8828125
26.46875
2.3984375
18.8515625
5.5390625
1.640625
0.84375
0.703125
0.527082853

20136D
67.25
61.90625
23.375
2.26953125
18.5234375
5.10546875
1.9453125
0.515625
0.5390625
0.022431653

Donor 2002
56.796875
61.90625
20.7734375
1.73046875
13.91796875
4.25
1.4765625
0.9140625
0.609375
0.019869899

Donor 20049
65.984375
62.234375
22.2265625
1.5546875
17.0234375
4.51953125
1.3125
0.515625
0.5859375
0.020950088

Donor 20035
62.375
62.3515625
21.546875
15.48828125
16.80078125
2.84375
1.0078125
0.4453125
0.421875
0.019283358

20095D
67.7421875
62.46875
23.890625
17.45703125
17.703125
4.00390625
1.2890625
0.46875
0.3984375
0.027034079

Donor 20032
68.046875
62.4921875

19.859375
20.84375

1.3125
0.65625

0.049918197

20073D
68.234375
62.515625
21.6640625
20.4453125
18.2421875
4.33203125
1.3125
0.609375
0.5390625
0.031841081

20075D
69.59375
62.8233125
24.3828125
16.63671875
16.578125
5.421875
1.4765625
0.703125
0.5625
0.039951448

20122D
69.5234375
62.84375
26.140625
11.1171875
15.8984375
4.61328125
2.109375
0.5625
0.6796875
0.035321697

Donor 20020
68.046875
62.84375
26.046875
1.9765625
13.4375
2.234375
1.875
0.65625
0.796875
0.034770379

20091D
66.453125
62.9140625
23.46875
2.01171875
18.4765625
4.30859375
1.4765625
0.65625
0.4453125
0.025758288

20081D
69.5234375
63.0546875
25.8125
3.23046875
19.96484375
5.59765625
1.6171875
0.4921875
0.6328125
0.016452223

Donor 20014
71.46875
63.2890625
26.0234375
1.90625
18.171875
5.703125
1.734375
0.515625
0.5625
0.041661201

Donor 20041
69.546875
63.546875
22.0390625
3.5234375
17.36328125
4.44921875
1.78125
0.6328125
0.7265625
0.023519527

20119B
67.0390625
63.7109375
22.203125
13.87109375
17.66796875
4.0390625
1.2890625
0.6328125
0.421875
0.02381942

20093D
71.5625
63.8515625
25.3671875
19.625
17.1875
5.75
2.484375
0.5625
0.65625
0.024585153

20118D
67.578125
63.8515625
22.34375
3.55859375
16.7890625
3.58203125
1.8984375
0.796875
0.6328125
0.020317437

Donor 20004
70.3203125
64.390625
27.78125
7.14453125
24.78125
4.51953125
1.7109375
0.796875
3.8671875
0.022439636

20069
68.65625
64.484375
25.484375
2.85546875
15.828125
5.5390625
2.0390625
0.9375
0.84375
0.010409081

20104B
65.3515625
64.6953125
27.4296875
17.41015625
24.21875
7.68359375
1.0546875
0.703125
0.4921875
0.035729727

20087D
69.4765625
64.953125
23.984375
18.1015625
18.7578125
5.8671875
1.40625
0.796875
0.46875
0.022928927

Donor 20026
70.90625
65
26.1640625
3.72265625
15.13671875
6.4765625
2.1796875
0.8671875
0.75
0.029490629

20128D
64.1796875
65.0234375
24.6875
5.52734375
15.3125
11.26953125
1.5234375
0.75
0.6796875
0.044331507

Donor 20022
63.0078125
66.3359375
23.3984375
13.71875
14.7265625
3.30378125
1.3125
0.703125
0.4921875
0.02218158

20130D
69.171875
66.3828125
22.5546875
1.58984375
23.12890625
4.8828125
1.4296875
0.5859375
0.609375
0.023212202

Donor 20015
75.1015625
67.015625
32.1171875
5.33984375
23.48046875
7.96484375
2.8828125
0.9140625
1.0546875
0.041298242

20103D
72.5703125
67.9765625
28.109375
10.2734375
24.265625
6.359375
1.921875
0.796875
0.75
0.038131123

Donor 20013
74.6328125
67.9765625
26.6328125
2.515625
18.4765625
6.41796875
2.484375
0.984375
0.6796875
0.015684863

20097D
66.640625
69.359375
20.375
14.10546875
16.49609375
3.44140625
1.2421875
1.0078125
0.3984375
0.023692686

Donor 20053
76.296875
71.3046875
31.3203125
12.93359375
21.21875
6.79296875
1.8984375
0.84375
0.8671875
0.028782681

CRT dA Integration
CN dA Integration
CFF dA Integration

Patient ID
CN LY30
CFF LY30
CRT CL30
CN CL30
CFF CL30
to Acrit (mm{circumflex over ( )}2)
to Acrit (mm{circumflex over ( )}2)
to Acrit (mm{circumflex over ( )}2)
CN Crit Prod

20150B
0.054626687
0.027442979
0.922646658
0.894579439
0.939624329
14.42779541
21.01464844
0.685546875
3.583374023

20131B
0.03083657
−0.006430128
0.91341592
0.92454226
1.003795867
55.03985596
35.0255127
11.60980225
4.739868164

20137B
0.030097212
0.024850274
0.921978799
0.931966618
0.947638604
4.075378418
52.4196167
6.858764648
5.654571533

Donor 20044
0.158564522
0.025780463
0.78810773
0.718055305
0.948208891
36.30432129
52.46905518
297.8486938
6.949310303

20152B
0.035774447
0.03306757
0.909178082
0.914996545
0.929343629
16.7744751
76.15338135
22.21435547
8.272247314

20100B
0.078264405
0.032046362
0.915829888
0.853393196
0.933732684
13.95648193
77.07623291
60.44018555
8.576568604

Donor 20058
0.021196962
0.009401352
0.919649856
0.942492013
0.978520286
14.59753418
35.77038574
8.762145996
4.359375

20108B
0.055939588
0.008846676
0.897693079
0.880924468
0.987056568
137.7454834
62.3303833
6.303405762
6.917999268

Donor 20063
0.016231848
0.011351955
0.918800293
0.948318701
0.975733064
9.897583008
26.38366699
6.593444824
3.443115234

20110B
0.037481321
−0.005831413
0.916296502
0.922748893
1.020737327
7.199890137
59.24377441
7.386108398
7.112548828

20153D
0.03837133
0.001880856
0.936002008
0.924225029
0.990856756
13.03857422
54.78277588
10.1282959
5.975921631

Donor 20024
0.047406741
0.024062717
0.890645939
0.892015707
0.961195361
133.9123535
61.14385986
19.03216553
6.890167236

Donor 20030
0.030500925
0.001550915
0.910755149
0.92704423
1.019064911
14.37835693
54.49603271
11.3939209
6.178436279

20072B
0.015311278
0.026953188
0.932561583
0.955997392
0.947699758
15.43798828
37.31286621
7.895324707
4.655273438

20079D
0.051418454
0.01426999
0.872471191
0.883002925
0.969322539
76.22094727
55.92645264
11.32965088
6.815460205

20149D
0.029747074
−0.008754644
0.946532653
0.0929623038
1.00955414
15.53192139
31.12646484
9.361999512
4.609130859

20146B
0.029046058
0.002625046
0.924523602
0.932832241
0.994483266
13.85925293
54.21258545
19.41119385
6.211395264

20156A
0.040872574
−0.014663284
0.927105991
0.906458797
1.047601476
12.55407715
60.21936035
24.66815186
7.626708984

Donor 20059
0.012877644
0.026754013
0.924791086
0.959453013
0.947308782
16.30810547
50.58544922
5.380554199
5.407470703

20151D
0.036162788
0.015357235
0.922543032
0.919252692
0.964051024
8.215026855
44.57702637
12.90838623
5.470458984

Donor 20017
0.03284789
0.009612168
0.876927553
0.922907142
0.983359746
8.26940918
47.06707764
18.23291016
5.330657959

Donor 20042
0.006529372
0.022183333
0.935529533
0.97264581
0.9568
19.70288086
50.45526123
3.640319824
5.511016846

20138D
0.023399896
0.005910018
0.901625792
0.938919342
0.985040798
10.56170654
57.3684082
9.422973633
6.501708984

Donor 2001
0.030189967
−0.010354148
0.949804592
0.93025433
1.014563107
198.2400513
54.50921631
6.537414551
9.819488525

20148B
0.044176398
−0.343559739
0.9330305
0.904200899
0.003662165
20.50213623
66.52935791
105.208374
8.14956665

20090B
0.044530954
0.013343385
0.883988619
0.898667493
0.970599322
61.87060547
69.78076172
17.21282959
8.704833984

20144B
0.024664914
0.00211955
0.96092312
0.939220538
0.988824503
9.510314941
59.581604
8.468811035
6.507293701

20078B
0.0397574
0.032274142
0.8883989428
0.90965251
0.935842601
8.946716309
65.0725708
9.99810791
7.796173096

20135B
0.059814843
0.020118734
0.925877251
0.887523049
0.959291368
182.315918
75.27008057
17.15844727
8.715545654

Donor 20048
0.03008713
0.025537019
0.931892779
0.937480846
0.955839058
25.76898193
46.86273193
4.401672363
6.245819092

Donor 20009
0.026344331
0.012003968
0.931993628
0.939790178
0.986745214
26.43475342
68.25970459
12.85400391
7.898712158

20117B
0.027881581
0.035371179
0.924625208
0.941667933
0.929257642
121.7373047
69.22869873
10.15301514
7.394439697

20076B
0.01924223
0.02673753
0.917068718
0.951116476
0.950975942
48.6293335
54.76135254
6.827453613
6.102539063

Donor 20019
0.001863276
0.010319222
0.963607401
0.980138429
0.981563674
203.8925171
49.21105957
9.816833496
5.885742188

Donor 20038
0.278638
0.036417674
0.910230835
0.935057126
0.928497409
121.1358032
55.23760986
14.70629883
6.437896729

20066
0.031155364
0.01533656
0.939500925
0.931338818
0.966231427
9.047241211
79.45422363
7.499816895
8.364257813

20147D
0.033383522
0.021421797
0.902052931
0.92160669
0.961078867
19.40130615
37.47930908
16.64099121
6.227874756

20158B
0.033309691
0.023378903
0.922172524
0.926534269
0.952904239
154.956665
63.73443604
14.00262451
7.562530518

20114B
0.02696704
0.001779683
0.944137094
0.937761194
0.99766173
108.7250977
63.23675537
14.72607422
7.648590088

20126D
0.109710199
0.005837412
0.930638029
0.806567164
0.980798193
16.9821167
76.05615234
2.073120117
9.448242188

Donor 20028
0.023107812
−0.008904859
0.928755598
0.942264658
1.014938886
7.016967773
48.56341553
8.37487793
5.975006104

Donor 20036
0.038066657
0.011970452
0.904877163
0.909633164
0.974368103
22.27532959
49.19952393
27.2109375
6.031219482

20127B
0.053709983
0.020658532
0.917356493
0.890892831
0.957644211
10.63256836
71.53088379
12.26733398
8.274169922

20106B
0.030807178
0.020493357
0.911609166
0.929827175
0.968201391
23.42230225
76.59503174
12.2244873
9.222747803

20085D
0.023255641
−0.007493108
0.919800125
0.944328979
1.007089405
18.01373291
52.26800537
7.194946289
7.115570068

20129B
0.028807898
023877814
0.930078985
0.933194774
0.95362083
142.3498535
57.01574707
13.45880127
6.892089844

20155D
0.023614407
0.016167408
0.938508187
0.944378523
0.974979149
21.53210449
61.49816895
22.1385498
7.46484375

Donor 20008
0.02103815
0.00228
0.926134906
0.944477347
1
69.38360596
50.48657227
12.7633667
6.277954102

Donor 20010
0.018110799
−0.006091718
0.931412713
0.952979447
1.009240246
205.680542
57.43432617
6.77142334
6.392578125

2011513
0.019098248
0.010429078
0.937839545
0.957028943
0.974468085
14.66674805
84.22009277
12.0135498
9.465820313

201010
0.027867496
0.009337058
0.933238453
0.933343143
0.98013245
12.74194336
72.55755615
14.88262939
8.096399854

20124D
0.057727962
0.02311456
0.892039191
0.893894922
0.948391922
25.14276123
102.321167
27.14172363
11.20202637

20145D
0.029634449
−0.016528727
0.93724645
0.93797654
1.0215905
43.99200439
69.5994873
5.809020996
7.760009766

Donor 20005
0.045045639
−0.009513752
0.935257311
0.925318495
1.017681729
13.49505615
52.74261475
16.94586182
5.824127197

Donor 20056
0.032245002
0.038925126
0.927628238
0.928206625
0.926860565
12.4354248
69.6159668
9.968444824
8.270507813

201610
0.030047298
0.040432645
0.871404636
0.922920598
0.92300885
11.79602051
62.04528809
4.207214355
6.990234375

Donor 20003
0.027663862
0.002012601
0.938224414
0.944018516
1.002100105
36.47076416
130.2588501
31.66699219
14.42221069

2008613
0.033799237
3.81E−04
0.920943657
0.927684758
0.994857731
17.7088623
62.7522583
22.92791748
7.32321167

Donor 20039
0.023091598
−0.008177156
0.916181144
0.947036027
1.006941231
19.96325684
64.29473877
5.260253906
7.460723877

20159D
0.020185119
0.022336164
0.920236895
0.953084648
0.955547524
19.22662354
81.96734619
15.30944824
9.047149658

Donor 20027
0.061528036
0.030110145
0.917759706
0.895543774
0.937391304
156.7545776
100.9484253
31.09680176
11.45755005

Donor 20061
0.005382218
0.00186621
0.941999763
0.975497922
0.991345114
27.33288574
38.02313232
16.60803223
4.845062256

20082B
0.028016378
0.008201792
0.922341024
0.936918896
0.984641638
5.176208496
68.65686035
9.922302246
7.520874023

20096B
0.01234881
0.021483583
0.953874092
0.962285714
0.956222132
64.88140869
38.86523438
6.565429687
5.797485352

Donor 20031
−0.006701786
−0.01510391
0.962154097
0.995285714
1.019221291
110.5444336
62.43585205
1.911621094
7.03024292

2012513
0.026111309
0.041437174
0.907468774
0.939272986
0.914453125
185.3300171
70.58001709
9.764099121
8.811309814

201570
0.021280609
−0.009133877
0.934807766
0.943621868
1.012761432
35.09802246
53.40179443
10.31945801
6.492645264

200888
0.008897823
0.010444395
0.956643002
0.971822969
0.978704525
140.0905151
79.40148926
8.343566895
8.368286133

Donor 20054
0.021942864
0.003445173
0.958883054
0.946230441
0.995372156
15.55169678
77.12072754
6.395690918
8.913574219

20141B
0.032637805
0.027701912
0.904755784
0.925904897
0.939133828
28.31011963
79.32568359
17.22271729
9.0234375

Donor 20052
0.018178811
0.007644814
0.946545315
0.95151687
0.981140548
16.95574951
74.86303711
7.892028809
8.088867188

20154B
0.039198078
0.019272149
0.914058739
0.915403146
0.964851826
318.8287354
86.66235352
18.76025391
9.307617188

20111D
0.035058589
0.01398226
0.864779076
0.917244306
1.001260504
11.9262085
72.05822754
18.81628418
8.499755859

Donor 20023
0.026219814
0.004001721
0.93634446
0.935602316
0.991738382
29.16210937
83.44390869
20.65704346
9.239959717

Donor 20045
0.026431042
0.009035581
0.875219446
0.93393563
0.979256698
109.1832275
68.46405029
18.89208984
7.683929443

20068
0.022136074
0.014169329
0.942663379
0.943586865
0.969329073
10.61444092
73.97808838
16.71514893
8.773040771

20160B
0.026974577
0.001812788
0.933920705
0.935587988
0.990112063
17.83410645
78.66485596
24.4720459
8.857452393

20105D
0.024768064
−0.015139172
0.91278621
0.944054964
1.02688391
10.42987061
72.78662109
8.246337891
8.2734375

Donor 20011
0.019395001
−0.015828483
0.959181172
0.955430974
1.036013096
85.6307373
90.99481201
17.77807617
10.87765503

Donor 20046
0.024525812
0.003056897
0.929325438
0.938612474
0.989970282
12.31842041
83.62518311
52.18725586
10.26480103

Donor 20025
0.024227855
9.74E−04
0.963432652
0.9453858
1.00931677
21.20251465
101.0687256
17.54901123
11.45874023

Donor 20057
−0.001850037
0.007844388
0.953648403
0.98656215
0.975510204
21.93255615
69.59454346
4.726318359
7.805328369

Donor 20034
0.089839161
0.014281715
0.905671571
0.817062937
0.973799127
255.2492065
116.1359253
32.17785645
12.64956665

Donor 20050
0.025734848
0.009057087
0.9426353
0.938741259
0.978194017
48.99188232
78.01721191
42.89941406
8.858642578

Donor 20040
0.110195606
0.0128806
0.942475085
0.823850133
0.972596781
25.91564941
84.21844482
11.01489258
9.474884033

20070
0.01853278
0.021710115
0.954102921
0.954418734
0.959705373
177.7263794
85.78564453
12.21624756
9.918457031

Donor 20021
0.03418404
0.004191025
0.911963883
0.918276581
0.992778542
146.1335449
111.3305054
27.13677979
12.77682495

20083B
0.007678877
−0.001578657
0.972196478
0.973359234
1.001045661
186.598938
67.07647705
24.83129883
8.39364624

20123B
0.088742387
0.008031119
0.9260297
0.828109899
0.987073609
15.44128418
58.38848877
19.63201904
8.476776123

20116D
0.012975699
0.012377694
0.909358289
0.957083906
0.970249901
18.28729248
61.83599854
10.85668945
7.606842041

Donor 20007
0.031328071
−0.007090395
0.88592372
0.927522306
1.017209909
136.1321411
100.861084
127.6237793
11.84729004

Donor 20006
0.042962748
0.006588498
0.933838078
0.904677485
0.996231156
93.28710938
104.8656006
26.24194336
12.46362305

Donor 20060
0.027774951
0.004994742
0.916617595
0.937712037
0.989675939
84.71942139
89.47869873
40.0715332
11.76974487

20064
0.032159975
9.17E−04
0.945202052
0.930819316
0.998963014
22.01000977
123.6604614
13.46868896
13.80111694

20098B
0.019252464
0.026261418
0.939470366
0.954015193
0.947803393
14.31903076
86.23718262
12.51617432
10.40917969

20112B
0.019984526
0.014676904
0.923516976
0.952426132
0.95193008
18.40759277
82.00195313
16.73822021
8.862670898

20084D
0.02959325
0.01943336
0.926884422
0.937000406
0.959297686
140.1745605
82.28704834
9.225219727
8.838409424

20077D
0.009964381
0.014003905
0.931991849
0.969971595
0.979778527
136.005249
63.19555664
6.870300293
7.230834961

Donor 20012
0.026588214
0.026460089
0.939851689
0.939131611
0.947331461
46.95666504
66.31347656
14.10644531
8.971369336

Donor 20051
0.0282808
−7.22E−04
0.908254771
0.933180346
0.994935854
5153601074
44.65283203
23.11743164
5.958251953

Donor 20029
0.040235236
0.0118316732
0.905981843
0.908514371
0.95834591
201.1849365
127.664978
23.58874512
13.89266968

20139B
0.031996581
0.017536114
0.912106538
0.922375654
0.968630185
39.67437744
95.60412598
27.92944336
12.37316895

Donor 20043
0.025334916
−0.011353755
0.930214526
0.939414204
1.018972332
8.505065918
65.78942871
11.39227295
8.016357422

Donor 20055
0.006258898
0.355654762
0.959776934
0.975173518
0.571428571
35.99285889
65.85040283
0.009887695
7.669464111

20142D
0.033247165
−0.006142433
0.940590494
0.923549033
1.008902077
105.5742188
104.3069458
30.98803711
14.20999146

20109D
0.02958799
0.00963191
0.929873068
0.934539649
0.983839938
18.49822998
101.1774902
23.00372314
11.44482422

20074B
0.026303772
0.019107598
0.944695397
0.939642621
0.966643502
48.4118042
70.91455078
22.12207031
8.956787109

Donor 20016
0.022948379
0.009179487
0.951688139
0.944407677
0.981538462
72.82287598
161.2765503
35.73248291
18.1489563

20132D
0.025035029
0.005946626
0.915478499
0.94810511
0.985498489
82.80786029
70.1350708
23.00372314
11.646698

20099D
0.026462046
−0.013231336
0.941184316
0.943903081
1.002549936
102.4249878
61.70910645
5.507446289
7.13671875

Donor 20018
0.013432926
6.21E0−4
0.948958862
0.961740731
0.991014601
31.47253418
74.39666748
26.77258301
8.358306885

20133B
−7.23E−34
−0.008082622
0.969643309
0.989008113
1.01077683
16.52893066
82.35131836
12.51617432
9.116088867

20120D
0.023425042
0.010314535
0.918711478
0.945497321
0.980459376
222.6000366
91.41998291
29.78997803
10.33859253

Donor 20047
0.020561902
−0.009360329
0.945523503
0.946344648
1.010007413
105.4539185
64.4331665
10.7578125
8.522918701

20121B
0.032133624
0.009660442
0.924949563
0.926094891
0.98111624
136.7023315
108.9755859
13.52471924
12.8236084

20067
0.036387622
−0.003856145
0.875807515
0.912442997
0.998925116
153.9547119
99.68444824
9.722900391
11.38330078

Donor 20037
0.028034546
0.018986307
0.889645777
0.942786715
0.96267653
11.84216309
80.40838623
14.2366333
8.811309814

Donor 20062
0.023038104
0.01319565
0.922383517
0.944430052
0.975008678
244.914917
101.2318726
24.81811523
11.62545776

20092B
0.022683333
0.011923631
0.949278629
0.947741935
0.976224784
216.5800781
97.90631104
13.76202393
11.90725708

Donor 20033
0.096808526
0.049121587
0.93923025
0.819118784
0.925682508
117.9585571
65.63781738
9.043945313
9.92578125

20102B
0.032849106
−0.008873434
0.930960209
0.932446264
1.047819549
91.86328125
96.72802734
33.78460693
11.18408203

20094B
0.012071477
0.009293042
0.965892772
0.969758836
0.987714073
31.93560791
106.9568481
10.24035645
12.30899048

20134D
0.026127863
0.014341442
0.926115764
0.938416422
0.969037965
9.996459961
67.71917725
2.796569824
11.94296265

20080B
0.023347729
0.020451634
0.905485951
0.944366823
0.956655395
245.0846558
83.91027832
20.39337158
12.23291016

20113D
0.03286058
0.004612521
0.875330291
0.921362543
0.987467866
237.548584
95.33221436
17.81433105
11.72927856

20140D
1
1
0.951892017
1
1
31.40002441
142.3432617
32.80407715
15.90600586

20136D
0.022472166
0.01052529
0.951208178
0.953054013
0.979946524
33.27044678
85.70654297
25.14935303
9.551147461

Donor 2002
0.022142472
−0.001980694
0.954195323
0.952675416
1
18.73553467
102.4777222
24.4720459
12.72189331

Donor 20049
0.005545443
0.003060926
0.958797064
0.977403967
0.989455185
14.84802246
76.41870117
25.08013916
8.777709961

Donor 20035
−0.005776741
−0.009875816
0.955661323
0.996616965
1.011965192
144.1444702
61.64154053
9.44934082
7.4815979

20095D
0.008573037
−0.013358404
0.940491293
0.971485743
1.013734467
225.9354858
68.21191406
14.21026611
8.298339844

Donor 20032
0.035924629

0.890815155
0.919364921

277.6662598
120.2178995

13.67871094

20073D
0.023220757
0.009871479
0.929929013
0.94563859
0.988099531
289.40625
91.93579102
19.81658936
11.11633301

20075D
0.042670895
0.00504913
0.91142793
0.900385524
0.982697853
257.40802
91.57983398
22.74169922
11.65649414

20122D
0.027525692
−0.00513424
0.930216878
0.938090502
1.006276151
224.470459
72.49328613
22.86859131
8.942871094

Donor 20020
0.022890249
0.005045241
0.923536165
0.945176529
0.982903419
25.84313965
71.97912598
9.452636719
8.818359375

20091D
0.01940219
−0.007108577
0.942158476
0.952688439
1.004993342
23.20477295
110.65979
17.00518799
12.12524414

20081D
-0.001491967
−0.00394093
0.962917182
0.988105563
1.00090799
47.89105225
83.4307251
22.50933838
9.826446533

Donor 20014
0.025575032
0.007622836
0.912439878
0.940748056
0.985589913
23.54919434
83.30383301
20.16101074
9.369873047

Donor 20041
0.046152809
0.005627437
0.949786565
0.920334399
0.987238568
50.97766113
94.82794189
24.20013428
10.98770142

20119B
0.007657879
0.021167605
0.952802704
0.974248927
0.955665025
174.1404419
97.82391357
15.67858887
11.18051147

20093D
0.016145642
−0.009099425
0.94628821
0.957420776
1.012011087
367.4399414
79.46740723
33.99719238
9.66796875

20118D
0.023174715
0.007876845
0.95283237
0.951180717
0.987412587
61.04168701
121.1506348
17.87860107
13.37878418

Donor 20004
0.027468387
0.004736127
0.949672259
0.941397719
0.993250844
121.7158813
173.2653809
69.75274658
19.74755859

20069
0.021366745
0.006801809
0.976786527
0.951659801
0.989883507
45.56744385
124.6541748
40.34179687
14.83886719

20104B
0.014632895
0.007350707
0.926838016
0.969568893
0.993164341
198.9783325
154.1293945
34.80633545
17.02880859

20087D
0.017378819
−0.005552389
0.954458563
0.956338706
1.004885993
270.4449463
118.2469482
20.77075195
14.94763184

Donor 20026
0.033851162
3.04E−04
0.933891582
0.922115385
0.99820842
71.36773682
106.2877808
40.62194824
13.12637329

20128D
0.023482618
0.011477672
0.908733591
0.94196804
0.979113924
77.29376221
87.25891113
62.69952393
11.484375

Donor 20022
0.012441605
−0.00942404
0.956106634
0.968201625
1.012020033
169.1784668
89.15075684
14.34869385
10.35461426

20130D
0.007788533
6.96E−04
0.946833705
0.973520066
0.991686872
15.94061279
121.3665161
26.18920898
13.55209351

Donor 20015
0.0451000839
−0.002598719
0.920108187
0.915364887
1.011675991
137.0714722
186.5791626
61.12738037
21.46261597

20103D
0.026895376
−0.007834213
0.922488965
0.93931732
1.020844914
201.2475586
169.8640137
34.12243652
19.33666992

Donor 20013
0.022569085
0.017489244
0.959833203
0.953108838
0.965679085
43.54870605
145.6160889
37.48260498
18.18786621

20097D
0.018750939
−0.004599629
0.949003517
0.959112413
1.005751534
171.539978
155.7394409
11.30657959
16.62496948

Donor 20053
0.025034087
0.008367285
0.943170182
0.947737482
0.989523572
252.0686646
150.3588867
48.98529053
17.90332031

TABLE 4

CRT Amax
CN Amax
CN + 75tPA Amax
CN + 150tPA Amax
CFF Amax
CFF + TXA Amax
CRT Acrit

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10027
55.7421875
58.625
43.1328125
19.3203125
19.015625
16.859375
0.86328125

10036
44.75
28.953125
5.703125
4.578125
11.703125
13.578125
1.25

10013
40.671875
42.9453125
18.0546875
13.203125
18.21875
17.9140625
1.73046875

10099
31.0859375
10.7421875
3.2421875
0.921875
9.96875
5.9609375
0.76953125

10107
52.3203125
42.734375
30.9453125
22.6484375
16.0390625
16.5546875
1.625

10093
51.125
54.8984375
40.5546875
26.3046875
12.3828125
13.6484375
1.53125

10044
21.6171875
20.984375
14.0703125
2.1171875
4.5546875
9.453125
0.59375

10068
47.84375
48.3359375
33.03125
15.9296875
7.4140625
10.8359375
12.48828125

10030
61.2265625
64.5078125
47.2578125
33.59375
22.015625
23.421875
1.8359375

10077
52.6015625
55.484375
51.0546875
40.765625
16.2265625
15.8046875
1.82421875

10016
28.1796875
28.5546875
14.0703125
6.5234375
16.8828125
12.265625
1.49609375

10075
46.203125
53.421875
44.8671875
27.6640625
21.0078125
19.7421875
3.04296875

10090
46.671875
45.6171875
31.859375
19.15625
9.0546875
10.203125
5.05859375

10059
60.6875
55.5546875
41.4453125
30.265625
15.1953125
18.03125
1.16796875

10061
52.8359375
58.7421875
55.15625
33.9921875
23.3046875
22.2734375
15.78125

10097
50.5859375
56.7265625
52.6953125
32.1171875
19.1328125
16.8828125
1.16796875

10025
62.234375
70.203125
64.4375
51.8984375
22.765625
23.1640625
1.9296875

10050
53.4453125
59.8671875
53.9375
32.9609375
19.9765625
18.921875
12.03125

10060
61.7890625
46.2734375
54.5
38.1171875
23
15.1484375
1.7890625

10032
59.7734375
61.6953125
52.6015625
45.9921875
20.9140625
19.4140625
12.76953125

10106
33.5
36.5
30.40625
12.453125
6.875
6.546875
0.9921875

10063
48.59375
64.7890625
63.3828125
53.375
23.0234375
21.640625
1.35546875

10088
63.5
59.984375
60.8046875
49.9296875
20.6796875
20.5625
13.51953125

10102
55.25
61.34375
48.4765625
22.6953125
10.71875
11.0703125
14.0703125

10115
72.5703125
70.5546875
68.7734375
51.5
27.8046875
27.640625
12.91015625

10014
62.515625
65.0234375
62.3046875
49.578125
18.640625
22.3671875
1.7421875

10085
64.0390625
69.453125
65.9609375
58.3671875
21.8984375
21.7109375
1.68359375

10047
62.703125
69.171875
61.015625
42.3828125
23.8203125
24.59375
10.44921875

10051
66.078125
68.65625
66.1015625
38.2109375
25.15625
24.078125
2.0703125

10056
61.859375
70.6015625
58.90625
52.4609375
25.578125
28.4609375
2.9609375

10057
67.5078125
68.1640625
64.15625
57.03125
25.6015625
26.46875
3.2421875

10039
65.09375
67.1796875
62.84375
56.2109375
21.96875
22.0859375
2.38671875

10067
58.484375
61.1328125
52.7890625
44.609375
22.203125
21.8046875
16.5546875

10071
55.2265625
56.703125
0.125
19.9765625
14.234375
13.390625
0.79296875

10104
64.4609375
68
64.0859375
65.6796875
27.171875
26.234375
2.890625

10001
56.84375
55.625
52.2265625
41.75
21.1953125
20.28125
1.73046875

10002
63.03125
64.2734375
63.921875
58.203125
26.28125
25.578125
17.9375

10003
66.6875
67.53125
60.8046875
44.6796875
26.2578125
25.0859375
6.0546875

10004
46.203125
34.203125
22.7890625
16.6015625
14.9609375
20.984375
0.828125

10005
56.5625
60.359375
58.7890625
47.796875
27.5234375
26.2578125
1.3203125

10006
63.8515625
62.2109375
59.0234375
39.4765625
23.7265625
23.4921875
1.8828125

10007
61.953125
65.5625
59.3515625
52.296875
35.75
25.0625
2.140625

10008
70.1796875
60.734375
48.5703125
35.703125
32.46875
27.640625
6.11328125

10009
71.5390625
70.4375
65.9609375
48.828125
29.5859375
29.2109375
8.55078125

10010
59.046875
61.5078125
57.7109375
48.7578125
21.875
21.2890625
34.51953125

10011
68.4453125
66.03125
59.1640625
54.3828125
25.296875
24.5703125
8.71484375

10012
52.015625
46.7890625
32.4453125
26.5625
17.7734375
19.53125
1.7421875

10015
68.6796875
69.359375
64.5078125
54.8984375
27.5
25.6953125
1.77734375

CN Arit
CN + 75tPA Acrit
CN + 150tPA Acrit
CFF Acrit
CFF + TXA Acrit
CRT dAmax
CN dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10027
9.69921875
11.890625
7.44921875
1.49609375
1.53125
0.7734375
1.0078125

10036
10.75390625
2.7265625
3.67578125
1.61328125
1.56640625
1.078125
0.4921875

10013
8.515625
7.578125
6.21875
4.1328125
4.390625
1.1484375
0.5625

10099
6.6640625
2.0703125
0.2421875
0.6875
0.23046875
0.5390625
0.140625

10107
7.07421875
9.37109375
7.61328125
1.37890625
2.234375
0.796875
0.4453125

10093
10.0390625
9.04296875
8.515625
1.26171875
1.0859375
0.84375
0.84375

10044
6.16015625
2.80859375
1.54296875
0.359375
1.484375
0.421875
0.3046875

10068
13.0859375
6.58203125
8.66796875
0.3125
32.9140625
0.4921875
0.515625

10030
12.7578125
12.41796875
13.7890625
5.4453125
4.37890625
1.171875
1.40625

10077
8.0703125
5.50390625
6.18359375
1.015625
1.0390625
1.5703125
0.9375

10016
27.1953125
0.69921875
1.0390625
1.58984375
3.58203125
1.0078125
7.453125

10075
5.3515625
7.015625
6.60546875
3.8984375
3.23046875
1.7578125
1.03125

10090
9.83984375
9.3359375
6.51171875
1.15625
0.359375
0.5390625
0.4921875

10059
15.3359375
13.63671875
13.63671875
2.38671875
2.01171875
1.0078125
0.703125

10061
14.140625
11.84375
12.1015625
4.671875
5.1875
1.546875
1.078125

10097
9.4296875
7.77734375
8.140625
3.3828125
1.015625
0.9140625
0.9375

10025
10.26171875
12.81640625
9.58203125
4.4140625
3.41796875
1.734375
1.6640625

10050
9.98046875
9.8984375
8.76171875
2.3984375
2.515625
0.75
1.0546875

10060
5.66796875
14.796875
10.4609375
4.16796875
3.69921875
1.734375
0.3046875

10032
13.14453125
12.6640625
13.625
3.3828125
2.64453125
1.0546875
1.0546875

10106
4.84765625
5.234375
3.7578125
0.40625
0.4296875
0.5625
0.3984375

10063
9.46484375
7.7890625
8.48046875
2.41015625
2.22265625
1.0078125
1.1953125

10088
16.61328125
16.015625
14.8671875
39.0546875
3.34765625
0.8671875
0.6328125

10102
12.6875
12.18359375
8.62109375
26.78515625
0.37109375
0.515625
0.65625

10115
17.87890625
17.328125
16.8125
4.16796875
4.23828125
0.8671875
0.7734375

10014
10.37890625
9.7578125
13.47265625
3.4765625
3.9921875
0.9375
1.1953125

10085
13.16796875
12.27734375
13.4609375
4.07421875
4.40234375
1.6171875
1.4296875

10047
13.296875
13.19140625
13.6484375
5.421875
4.37890625
7.3828125
1.265625

10051
14.26953125
15.1484375
14.57421875
5.55078125
4.25
1.359375
1.4765625

10056
10.66015625
10.25
12.67578125
3.95703125
6.2890625
1.6875
1.4296875

10057
11.65625
10.91796875
11.52734375
4.44921875
5.7265625
1.875
1.921875

10039
12.875
9.6171875
10.28515625
1.6015625
2.99609375
1.2890625
1.03125

10067
12.3359375
11.5859375
12.62890625
43.54296875
3.5703125
0.75
0.75

10071
9.3125
0.125
9.265625
2.3046875
2.046875
0.7265625
0.515625

10104
11.73828125
9.81640625
10.91796875
5.421875
4.91796875
1.546875
1.3359375

10001
13.00390625
13.96484375
9.8046875
3.3828125
2.984375
1.4296875
0.6796875

10002
14.3984375
12.34765625
12.95703125
3.93359375
4.47265625
0.75
0.984375

10003
16.015625
15.16015625
14.0703125
6.3828125
6.1015625
1.40625
1.078125

10004
16.25
10.51953125
5.234375
2.9609375
1.16796875
0.703125
0.515625

10005
11.84375
11.83203125
11.15234375
2.41015625
1.625
1.03125
0.984375

10006
14.97265625
13.80078125
10.390625
4.42578125
4.859375
1.546875
0.9609375

10007
11.84375
8.94921875
12.65234375
14.17578125
4.390625
1.453125
1.171875

10008
14.10546875
18.55859375
15.34765625
8.9609375
6.8046875
1.3828125
0.6796875

10009
19.51953125
21.13671875
15.55859375
5.03515625
6.453125
1.5703125
1.1015625

10010
10.42578125
12.91015625
10.3671875
4.82421875
3.13671875
2.2734375
1.0546875

10011
13.05078125
13.40234375
13.70703125
5.31640625
5.22265625
1.4296875
0.8671875

10012
12.03125
9.58203125
11.15234375
2.0234375
1.96484375
0.9375
1.03125

10015
14.97265625
16.00390625
14.22265625
6.265625
5.36328125
1.2890625
1.0546875

CN + 75tPA dAmax
CN + 150tPA dAmax
CFF dAmax
CFF + TXA dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
CRT LY30
CN LY30

10027
0.9375
0.8203125
0.8203125
0.28125
0.032181149
0.036531072

10036
0.1875
0.1640625
1.1015625
0.2578125
0.620687849
0.570174492

10013
0.515625
0.609375
0.5625
0.421875
0.122440453
0.17333015

10099
0.09375
0.046875
0.515625
0.1171875
0.700512063
0.676866667

10107
0.5859375
0.7265625
0.7265625
0.46875
0.206567617
0.301307892

10093
0.8203125
0.84375
0.3515625
0.234375
0.157658839
0.205500806

10044
0.3515625
0.0703125
0.1875
0.28125
0.795071377
0.8215557

10068
0.5859375
0.4921875
0.140625
0.140625
0.413549604
0.333138705

10030
1.4765625
1.3125
0.796875
0.8671875
0.049018013
0.048666115

10077
1.0546875
1.2421875
0.703125
0.65625
0.104187707
0.107589411

10016
1.1484375
1.828125
1.0546875
0.2109375
−3.82E−04
0.10379731

10075
1.078125
1.0546875
0.75
0.6328125
0.013590398
0.005073974

10090
0.46875
0.4921875
0.140625
0.234375
0.273513001
0.251932409

10059
0.7265625
0.6796875
0.2578125
0.2109375
0.403412504
0.205224691

10061
1.125
0.984375
0.796875
0.65625
0.01238212
0.016334176

10097
1.1953125
0.890625
1.03125
0.703125
0.013837838
0.020287418

10025
1.6171875
1.6640625
0.9375
0.9609375
0.020103147
0.020015858

10050
1.078125
1.0078125
0.515625
0.421875
0.017763607
0.016338611

10060
0.890625
0.984375
0.7734375
0.3046875
0.033260983
−0.087673758

10032
1.078125
1.078125
0.703125
0.5859375
0.079844138
0.07552534

10106
0.375
0.421875
0.140625
0.234375
0.037628265
0.009302761

10063
1.125
1.1953125
0.4453125
0.3515625
0.036809352
0.00174796

10088
0.65625
0.703125
0.5625
0.3515625
0.033335384
0.038860489

10102
0.5859375
0.5859375
0.1640625
0.2109375
0.013800905
0.004507344

10115
0.890625
0.65625
0.6796875
0.7265625
−9.07E−04
0.00166233

10014
1.40625
0.5859375
0.609375
0.609375
0.036194424
0.0174196

10085
1.4296875
1.265625
1.0546875
0.7265625
0.012515249
0.014965317

10047
1.4296875
1.171875
0.609375
0.7265625
0.015036548
0.023598091

10051
1.78125
0.9609375
0.8203125
0.609375
0.051359495
0.036818989

10056
1.3125
1.2890625
0.7265625
1.125
0.040883465
0.030727841

10057
1.8984375
1.8984375
0.9609375
1.078125
0.02123211
0.019522923

10039
1.265625
1.2421875
0.796875
0.7734375
0.030087314
0.021265554

10067
0.5625
0.8203125
39.2578125
0.5625
0.024026887
0.023099042

10071
0
0.515625
0.234375
0.1875
0.029964163
0.015405989

10104
1.7109375
1.6171875
0.984375
0.9140625
0.02263059
0.016736079

10001
0.7265625
0.65625
0.46875
0.515625
0.044339839
0.035448853

10002
1.1484375
1.0078125
0.5390625
0.4921875
0.020561684
0.01556089

10003
1.3359375
1.3125
0.984375
0.84375
0.023201246
0.02049543

10004
0.5390625
0.46875
0.75
0.5859375
0.673048416
0.667148241

10005
1.0546875
1.0078125
1.8515625
1.3125
0.06026761
0.049426

10006
1.1484375
1.21875
0.7734375
0.5625
0.034280048
0.006880259

10007
1.2890625
1.1953125
2.0859375
0.84375
0.014223939
0.015482503

10008
0.4453125
0.5390625
0.9375
0.609375
0.040747338
0.03000636

10009
1.0078125
0.8671875
0.7265625
0.75
0.026999381
0.014878642

10010
1.1015625
1.078125
0.8203125
1.5703125
0.034516958
0.035916

10011
0.8671875
1.1484375
0.5390625
0.4921875
0.023568783
0.021000454

10012
1.0078125
0.9140625
1.5
1.2890625
0.490499524
0.474602744

10015
1.0546875
0.9140625
0.5625
0.5859375
0.021365601
0.017188087

CN + 75tPA
CN + 150tPA

CFF + TXA

CN + 75tPA
CN + 150tPA

Patient ID
LY30
LY30
CFF LY30
LY30
CRT CL30
CN CL30
CL30
CL30

10027
0.610296293
0.877309947
0.001396878
−0.018850402
0.912123336
0.934834755
0.003984785
0.006469875

10036
0.883573059
0.90988339
0.723025145
−0.033342923
0.003840782
0.007555316
0.021917808
0.027303754

10013
0.764863695
0.920766765
0.18963098
−0.028770534
0.593161736
0.525195561
0.008221549
0.011242604

10099
0.862426372
0.803248588
0.741447884
−0.040334207
0.005529027
0.022545455
0.038554217
0.13559322

10107
0.721292673
0.869580028
0.486720653
−0.010193487
0.418545617
0.257952468
0.004039384
0.007588824

10093
0.659639012
0.875379913
0.443278128
−0.036288399
0.524144254
0.459086381
0.003660181
0.004752005

10044
0.874518786
0.844049815
0.814686964
−0.038434343
0.005782436
0.007073716
0.010549695
0.05904059

10068
0.684876616
0.863611367
0.646364594
−0.02922074
0.111365121
0.201390011
0.005203406
0.007383479

10030
0.5668166
0.87458624
0.190315235
−0.015613187
0.874441751
0.840135642
0.003636965
0.004418605

10077
0.630032517
0.814858822
0.300028085
0.030363322
0.632407545
0.656153196
0.002448355
0.003066309

10016
0.824400796
0.90074684
0.133519718
−0.037340764
0.95092875
0.708618331
0.008883953
0.019161677

10075
0.66195731
0.882000141
−0.01578034
−0.017857143
0.97717281
0.983767183
0.002786
0.004518498

10090
0.654669364
0.873151169
0.479155882
−0.01954441
0.329092735
0.370097619
0.00980873
0.006525285

10059
0.634131061
0.750124763
0.628603256
−0.01975195
0.048403708
0.434256785
0.003016023
0.004130098

10061
0.341356822
0.715671685
0.025839479
0.022295783
0.976489723
0.968080862
0.085127479
0.003677316

10097
0.295816654
0.749214506
−0.006116442
−0.006813975
0.967567568
0.959096543
0.217642698
0.003891997

10025
0.301405728
0.60935634
0.018522173
0.001226813
0.951041928
0.950255954
0.20271581
0.00240855

10050
0.239333478
0.692515011
−0.002336723
−0.001073493
0.960532086
0.967506199
0.334733488
0.003792368

10060
0.297550929
0.694521589
0.009783552
−0.057673629
0.937792388
1.141820024
0.236238532
0.003279361

10032
0.051217676
0.417378452
−0.010187088
−0.006750503
0.859234087
0.875775611
0.882370414
0.040428062

10106
0.455055955
0.935377457
0.003082386
−0.075740851
0.907649254
0.969820205
0.063463515
0.010037641

10063
0.006560459
0.550600117
−0.008719319
−0.015025572
0.932958199
0.987338719
0.974855171
0.00234192

10088
0.074793888
0.391418053
0.013625488
−0.012183384
0.926181102
0.90974212
0.789926763
0.08699734

10102
0.562845152
0.848988812
5.16E−04
0.005384027
0.972002262
0.984717269
0.002578566
0.005507745

10115
0.072674562
0.491382863
−0.014777091
−0.013430375
0.99515556
0.991030894
0.776780643
0.017445388

10014
0.016686346
0.239035744
−0.001005868
9.21E−04
0.930642339
0.961792623
0.966520376
0.34714781

10085
0.019434574
0.426500617
−0.00628196
0.00456849
0.971818958
0.965579303
0.957005804
0.040289118

10047
0.31609724
0.653241935
0.028920684
0.002780866
0.961126339
0.940027106
0.18950064
0.002949309

10051
0.129969698
0.588880654
0.003277692
0.00937838
0.900685741
0.916021848
0.617421109
0.013085259

10056
0.049351606
0.304203276
0.009619986
6.10E−04
0.918161152
0.934270222
0.842838196
0.175725987

10057
0.097372578
0.54744863
0.002834147
0.001678309
0.952088879
0.952893983
0.667924988
0.003013699

10039
0.065426612
0.356663192
−8.83E−04
0.001954369
0.937710034
0.951157111
0.806439582
0.131063238

10067
0.127341193
0.52226187
−0.089839901
−0.023327959
0.949104996
0.947476038
0.636821074
0.004378284

10071
1
0.823419372
0.074108123
0.010054454
0.913000424
0.946266189
1
0.009777083

10104
0.473321752
0.343410253
0.015296147
0.009525346
0.954550964
0.960018382
0.007070584
0.101463066

10001
0.125558464
0.574256955
0.003027092
0.014933231
0.905992303
0.920365169
0.639192221
0.003555389

10002
0.025736373
0.048507271
−0.026026803
−0.025764865
0.952032722
0.970827762
0.939868003
0.883221477

10003
0.285959784
0.639335257
3.64E−04
−0.006207827
0.950445173
0.953840814
0.20441989
0.003322259

10004
0.766353845
0.823688235
0.835254569
−0.004840428
0.004734528
0.005025126
0.005485087
0.007529412

10005
0.075513843
0.383931977
−0.028563488
−0.02444461
0.87859116
0.892052809
0.809435216
0.128636809

10006
0.121344584
0.527154661
0.009525573
0.010931438
0.93723235
0.979279166
0.615618795
0.003166436

10007
0.175179896
0.483857435
−0.017598157
−0.017704437
0.970870113
0.968898951
0.515861524
0.023453839

10008
0.186974559
0.347914843
−0.022982836
−0.014046307
0.914505176
0.936712117
0.529515844
0.214223195

10009
0.07481
0.452688
0.003454802
4.71E−04
0.941683958
0.963065661
0.794978088
0.02848

10010
0.153788562
0.578757411
−0.007364583
7.22E−04
0.926964806
0.919979677
0.568701773
0.005447845

10011
0.034518465
0.19155214
−0.013607937
−0.027164812
0.945896587
0.949952674
0.914828998
0.496624048

10012
0.691469018
0.849708333
0.680998168
−0.020095
0.024932412
0.07380197
0.003852637
0.004705882

10015
0.094819042
0.270578957
−0.007755682
−0.005489257
0.950176317
0.959788241
0.737313794
0.369005265

CFTX dV @ CFF max
CN dV @ CN + tPA75 max
CRT dA Integration to Acrit

Patient ID
CFF CL30
CFF + TXA CL30
(mm/min)
(mm/min)
(mm{circumflex over ( )}2)

10027
0.98767461
1.029193698
0
0.84375
4.167663574

10036
0.010680908
1.058688147
0.421875
3.65625
3.351928711

10013
0.428816467
1.064108155
0.28125
2.953125
0.851989746

10099
0.202978056
1.086500655
0.28125
1.6875
0.16973877

10107
0.054554311
1.022652194
0.421875
1.546875
0.385620117

10093
0.14637224
1.077275329
0.140625
1.265625
0.853637695

10044
0.027444254
1.084297521
0.28125
1.96875
0.402099609

10068
0.035827187
1.080028839
0.5625
1.96875
55.67266846

10030
0.444286728
1.030020013
0.140625
1.96875
0.866821289

10077
0.254694271
0.922886802
0.28125
0.84375
0.374084473

10016
0.601573346
1.072611465
0.28125
1.96875
11.56695557

10075
1.033469691
1.035615354
0
0.84375
45.57073975

10090
0.119930975
1.036753446
0.28125
1.40625
13.43243408

10059
0.028277635
1.035095321
0.28125
1.546875
1.507873535

10061
0.954743547
0.967379867
0.140625
0.140625
158.5063477

10097
1.013474888
1.011105969
0
0.28125
7.57232666

10025
0.963967056
0.998988196
0.140625
0.421875
24.0534668

10050
1.0023465
1.002477291
0
0.28125
71.05297852

10060
0.991847826
1.103661681
0.140625
0.84375
21.12670898

10032
1.016809862
1.014486922
0
0.5625
144.5267944

10106
0.928409091
1.132458234
0
0.5625
4.676879883

10063
1.00916186
1.022743682
0
0.140625
10.36724854

10088
0.984132981
1.036474164
0.140625
0.140625
108.4498901

10102
1.008746356
0.993648553
0
0.984375
60.84887695

10115
1.048890138
1.028829847
0.140625
0.28125
85.81365967

10014
1.015088013
0.996856444
0
0
13.54943848

10085
1.019265073
0.994602375
0
0.140625
18.49822998

10047
0.914398163
0.999047014
0.140625
0.5625
685.0376587

10051
0.999068323
0.985399091
0
0.28125
22.11547852

10056
0.978924863
1.000823497
0.140625
0.421875
44.68249512

10057
0.995422643
1.001770956
0
0.140625
50.58215332

10039
0.997866287
0.997877609
0
0.28125
27.48944092

10067
1.329345531
1.064493013
−0.140625
0.421875
130.4022217

10071
0.761251372
0.982497083
0.140625
1.125
3.468933105

10104
0.9706728
0.991066111
0.140625
0.703125
40.84606934

10001
0.990047917
0.969953775
0
0.28125
18.53118896

10002
1.070451843
1.076053757
0
0.421875
33.03479004

10003
0.998214817
1.026160075
0.140625
0.84375
88.00708008

10004
0.008355091
1.048026806
0.84375
3.65625
0.405395508

10005
1.04513199
1.037488843
0.140625
0.28125
10.16784668

10006
0.981231478
0.983039574
0.140625
0.28125
22.12866211

10007
1.029501748
1.04021197
0.421875
0.421875
25.69812012

10008
1.054860443
1.038157151
0
0.421875
79.16253662

10009
0.995246897
1.005616475
0.140625
0.28125
126.6432495

10010
1.0225
1.008807339
0
0.421875
342.4257202

10011
1.03428042
1.072496025
0
0.140625
120.1107788

10012
0.007032967
1.0348
0.5625
2.671875
1.974243164

10015
1.025568182
1.020979021
0
0.140625
16.7744751

CN dA Integration to Acrit
CN + 75tPA dA Integration to Acrit
CN + 150tPA dA Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10027
85.9520874
101.4642334
45.04669189

10036
35.29083252
3.318969727
5.532165527

10013
30.48376465
26.18261719
28.65124512

10099
7.577270508
1.272216797
0.019775391

10107
19.28265381
41.2300415
48.57000732

10093
56.30053711
62.28094482
61.1685791

10044
18.49493408
7.592102051
0.552062988

10068
57.52990723
26.35565186
37.64080811

10030
124.614624
154.8099976
178.7167969

10077
54.78771973
52.32073975
70.82391357

10016
47.28295898
0.248840332
0.771240234

10075
46.79187012
69.48083496
39.81280518

10090
25.65362549
35.08813477
22.11383057

10059
84.42773438
79.0010376
80.16778564

10061
129.7397461
115.2773438
100.2183838

10097
77.203125
74.16265869
68.04382324

10025
150.218811
161.7544556
138.9138794

10050
81.03790283
91.74462891
71.90496826

10060
14.2399292
119.973999
86.43164063

10032
95.99468994
120.9364014
131.7700195

10106
18.36639404
10.99182129
13.90209961

10063
70.71185303
78.4588623
91.31121826

10088
94.48846436
91.61279297
64.3458252

10102
56.65649414
65.57684326
44.1897583

10115
121.9993286
85.35388184
97.12023926

10014
111.3931274
118.4084473
66.15362549

10085
173.6295776
155.6900024
159.0864258

10047
147.9067383
162.7630005
143.6055908

10051
186.1671753
231.9521484
107.1282349

10056
126.6663208
54.03625488
143.7094116

10057
200.618042
164.661438
188.5501099

10039
123.7412109
88.77832031
101.6867065

10067
79.40478516
48.34094238
90.79046631

10071
37.39196777
0
39.15856934

10104
138.3964233
144.7278442
159.5033569

10001
75.84356689
60.63299561
53.13317871

10002
134.4034424
122.3388062
120.6018677

10003
157.7351074
175.6664429
143.7802734

10004
75.09375
51.08477783
17.79125977

10005
105.791748
104.5079956
97.47784424

10006
92.40875244
124.972229
106.2235107

10007
125.6231689
73.32220459
135.4202271

10008
75.42169189
47.03411865
63.8102417

10009
176.0454712
181.0288696
114.6494751

10010
90.99481201
116.6401978
93.13879395

10011
102.0822144
104.9727173
72.57733154

10012
84.82324219
82.31671143
86.3838501

10015
146.3724976
146.1582642
81.92449951

CFF dA
CFF + TXA dA

Integration to Acrit
Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
ID
SBP
HR
OR?
ICU?
Death?
pRBC
FFP
PLT

10027
10.11346436
4.268188477
10027
150
Unk
Yes
Yes
Yes
61
12
2

10036
5.04107666
3.314025879
10036
0
0
Yes
Yes
No
32
8
3

10013
2.231323242
16.37072754
10013
96
100
Yes
Yes
Yes
29
16
5

10099
0.260375977
0.087341309
10099
80
120
Yes
Yes
Yes
27
12
4

10107
0.393859863
9.271362305
10107
0
130
Yes
Yes
Yes
24
13
2

10093
0.271911621
0.557006836
10093
70
140
Yes
Yes
No
23
12
2

10044
0.052734375
3.348632813
10044
140
93
Yes
Yes
No
21
12
1

10068
0.046142578
18.60534668
10068
160
70
No
Yes
Yes
14
12
2

10030
18.28894043
30.75897217
10030
180
40
Yes
Yes
Yes
12
8
2

10077
0.283447266
5.164672852
10077
0
110
Yes
Yes
No
11
4
1

10016
14.26629639
7.041687012
10016
0
130
Yes
0
Yes
6
2
0

10075
29.9630127
18.2477417
10075
100
100
Yes
Yes
No
9
4
2

10090
0.177978516
0.411987305
10090
Unk
Unk
Yes
Yes
No
9
4
2

10059
2.480163574
3.093200684
10059
180
150
Yes
Yes
Yes
8
6
1

10061
35.8560791
32.24707031
10061
108
112
Yes
Yes
No
7
6
2

10097
30.8001709
5.164672852
10097
104
130
Yes
Yes
No
7
4
1

10025
38.51916504
28.14532471
10025
204
102
Yes
Yes
Yes
6
4
1

10050
11.390625
10.31945801
10050
107
89
Yes
Yes
No
6
4
1

10060
25.09991455
8.211730957
10060
70
112
Yes
Yes
No
6
3
0

10032
20.671875
13.52142334
10032
0
0
Yes
Yes
No
5
6
1

10106
0.385620117
0.639404297
10106
0
122
Yes
Yes
No
5
3
0

10063
10.2288208
6.98236084
10063
80
100
Yes
Yes
No
4
2
1

10088
49.21435547
11.0725708
10088
102
110
Yes
Yes
No
4
4
1

10102
19.89239502
0.430114746
10102
122
90
Yes
Yes
Yes
4
5
2

10115
19.7210083
26.19085693
10115
102
130
Yes
Yes
<28 d
4
4
2

10014
15.51049805
20.10827637
10014
80
110
Yes
Yes
No
3
1
0

10085
35.84454346
24.3583374
10085
132
108
Yes
Yes
No
3
0
0

10047
25.88598633
27.24554443
10047
0
120
Yes
Yes
No
2
1
0

10051
40.11602783
22.52087402
10051
110
124
Yes
Yes
No
2
0
0

10056
25.6206665
60.17321777
10056
108
100
Yes
Yes
No
2
0
0

10057
38.38238525
52.54980469
10057
90
130
Yes
Yes
No
2
2
0

10039
10.98852539
21.26019287
10039
140
120
Yes
Yes
No
1
0
0

10067
103.7993774
16.0378418
10067
100
120
Yes
Yes
No
1
0
0

10071
4.624145508
2.059936523
10071
90
80
Yes
Yes
No
1
2
0

10104
47.8861084
30.43267822
10104
100
72
Yes
Yes
No
1
0
0

10001
13.2989502
13.25280762
10001
132
90
No
0
No
0
0
0

10002
17.91815186
20.62738037
10002
110
110
Yes
0
No
0
0
0

10003
55.2557373
47.34228516
10003
118
120
Yes
Yes
No
0
0
0

10004
7.280639648
5.517858887
10004
0
0
No
Yes
No
0
0
0

10005
35.14910889
15.49072266
10005
124
120
Yes
0
No
0
0
0

10006
32.91778564
21.35083008
10006
60
86
No
0
No
0
0
0

10007
273.8776245
30.1673584
10007
98
66
Yes
Yes
No
0
2
0

10008
73.72595215
37.30297852
10008
84
90
Yes
0
No
0
0
0

10009
28.65618896
37.08874512
10009
72
112
Yes
Yes
No
0
0
0

10010
35.91375732
45.75531006
10010
Walk-in
Walk-in
No
0
No
0
0
0

10011
25.35040283
20.23187256
10011
124
72
Yes
0
No
0
0
0

10012
19.26452637
20.21868896
10012
0
0
No
Yes
Yes
0
0
0

10015
29.44885254
28.83416748
10015
122
112
Yes
Yes
No
0
0
0

Patient ID
CRYO
CN Crit Prod

10027
6
9.774993896

10036
4
5.292938232

10013
0
4.790039063

10099
6
0.937133789

10107
2
3.150238037

10093
2
8.470458984

10044
1
1.876922607

10068
1
6.747436523

10030
1
17.94067383

10077
0
7.565917969

10016
0
202.6900635
Artefact- Spike at end

10075
0
5.518798828

10090
2
4.843048096

10059
2
10.78308105

10061
0
15.24536133

10097
0
8.840332031

10025
1
17.07614136

10050
0
10.52627563

10060
0
1.726959229

10032
0
13.8633728

10106
0
1.931488037

10063
0
11.31344604

10088
0
10.51309204

10102
2
8.326171875

10115
0
13.82821655

10014
0
12.40603638

10085
0
18.82608032

10047
0
16.82885742

10051
0
21.06985474

10056
0
15.24069214

10057
0
22.40185547

10039
0
13.27734375

10067
0
9.251953125

10071
1
4.801757813

10104
0
15.68161011

10001
0
8.838592529

10002
0
14.17346191

10003
0
17.2668457

10004
0
8.37890625

10005
0
11.65869141

10006
0
14.38778687

10007
0
13.87939453

10008
0
9.587310791

10009
0
21.50198364

10010
0
10.99594116

10011
0
11.31747437

10012
0
12.40722656

10015
0
15.79147339

CRT Amax
CN Amax
CN + 75tPA Amax
CN + 150tPA Amax
CFF Amax
CFF + TXA Amax
CRT Acrit

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10017
59.5625
62.84375
58.6953125
45.59375
21.171875
19.71875
1.96484375

10019
67.765625
68.9609375
62
52.015625
27.8046875
25.765625
2.36328125

10020
68.9609375
66.2890625
62.890625
51.828125
23.8671875
23.328125
2.2109375

10021
10.6953125
15.546875
15.3125
11.6796875
16.6484375
9.5703125
0.62890625

10022
59.890625
64.4140625
59.84375
61.0859375
22.296875
19.7421875
1.1796875

10023
63.1015625
68.4453125
55.6015625
35.3046875
32.234375
32.5390625
11.01171875

10024
62.46875
66.8984375
57.8515625
38.6796875
22.203125
20.46875
1.1796875

10026
51.6875
50.515625
52.7421875
25.5859375
13.90625
13.7890525
11.41015625

10028
64.0390625
69.59375
66.6171875
57.8984375
27.640625
26.84375
1.484375

10029
65.6796875
65.140625
47.84375
29.421875
25.1328125
26.375
7.09765625

10031
61.8359375
61.1796875
49.0625
33.6640625
23.8203125
24.0078125
14

10033
62.0234375
66.59375
57.9453125
42.1484375
24.5234375
24.2421875
1.75390625

10034
60.640625
57.6875
43.0625
31.1796875
20.609375
17.8203125
14.33984375

10035
56.65625
60.5
52.6015625
47.0234375
20.046875
19.671875
1.89453125

10037
66.40625
70.53125
66.875
62.46875
25.25
24.6640625
1.859375

10038
60.8046875
58.625
51.7578125
51.0546875
23.0234375
24.8046875
4.28515625

10040
65.5859375
61.2265625
49.296875
46.6484375
25.8125
23.65625
6.55859375

10041
59.140625
63.546875
55.203125
35.3515625
21.1953125
21.0546875
1.14453125

10042
62.75
63.78125
56.5859375
44.28125
22.9296875
21.4765625
2.1875

10043
62.8671875
64.015625
54.6640625
36.640625
19.765625
19.6953125
4.77734375

10045
62.65625
63.171875
48.171875
25.6484375
27.9921875
23.703125
12.1015625

10046
49.6953125
55.7890625
51.40625
31.578125
19.15625
17.65625
0.8984375

10048
74.703125
73.8828125
65.890625
56.1171875
31.6953125
34.484375
7.84765625

10049
58.7421875
62.609375
55.4140625
49.859375
19.6484375
17.984375
14.66796875

10052
71.796875
70.2734375
67.0390625
35.234375
31.34375
29.3984375
7.578125

10053
65.5625
66.359375
62.0703125
57.6171875
24.2421875
23.5859375
1.6953125

10054
59.4453125
59.9375
50.4921875
41.65625
21.4765625
21.1484375
12.96875

10055
66.40625
66.21875
48.2890625
50.7734375
28.671875
26.84375
6.16015625

10058
57.8984375
58.7890625
50.84375
32.609375
21.6171875
20.84375
2.09375

10062
62.5859375
64.7421875
63.40625
58.9765625
25.4375
24.4765625
1.28515625

10064
72.78125
71.8671875
72.6640625
66.1953125
36.40625
34.9296875
5.73828125

10065
57.0546875
58.25
49.203125
35.3984375
21.2421875
22.15625
4.15625

10069
65.5625
69.9921875
70.8125
69.9453125
28.8125
28.4375
2.7265625

10070
48.546875
58.34375
52.9296875
46.1328125
17.2578125
15.6875
1.56640625

10072
67.9765625
64.25
63.8515625
54.921875
21.078125
22.203125
13.26171875

10073
72.078125
73.8828125
71.984375
28.5078125
31.9296875
93.78125
7.0859375

10074
64.7890625
67.7890625
62.328125
51.265625
20.140625
20.515625
1.58984375

10076
63.8984375
66.125
59.84375
49.765625
23.09375
23.375
2.66796875

10078
68.2578125
65.4921875
61.2734375
52.3203125
27.734375
26.28125
7.765625

10079
70.1328125
71.6328125
67.8828125
41.4921875
40.0390625
31.0625
2.48046875

10080
56.0234375
55.859375
56.75
36.8515625
18.2421875
16.4609375
11.69140625

10081
69.3359375
68.46875
67.296875
62.984375
27.4765625
25.4375
17.10546875

10082
53.703125
51.40625
54.9921875
53.3515625
20.1171875
18.8515625
2.1171875

10083
58.6015625
62.328125
61.6484375
55.15625
25.15625
22.390625
2.43359375

10084
63.640625
65.2578125
63.4765625
57.4765625
27.265625
26.1875
6.23046875

10086
65.65625
64.6953125
62.75
46.3671875
26.234375
24.5703125
17.796875

10087
70.34375
66.59375
66.6875
59.046875
31.625
33.9453125
14.03515625

10089
63.40625
72.1953125
68.2578125
60.0078125
27.171875
28.4609375
3.2421875

CN Arit
CN + 75tPA Acrit
CN + 150tPA Acrit
CFF Acrit
CFF + TXA Acrit
CRT dAmax
CN dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10017
13.77734375
15.2421875
13.02734375
3.78125
3.65234375
1.3359375
0.7734375

10019
16.12109375
13.66015625
9.0078125
1.484375
4.4140625
1.6640625
1.1953125

10020
16.37890625
14.1171875
13.44921875
4.80078125
5.31640625
1.359375
0.8671875

10021
2.41015625
3.6171875
2.1640625
2.984375
1.2734375
0.5390625
0.5390625

10022
11.046875
10.49609375
12.39453125
1.3203125
1.1796875
0.984375
0.9375

10023
16.51953125
13.0625
13.0625
4.4140625
6.58203125
1.5234375
1.1953125

10024
6.78125
18.69921875
10.484375
3.921875
3.265625
0.9375
1.171875

10026
10.56640625
8.7734375
7.89453125
0.32421875
1.671875
0.7265625
0.8203125

10028
14.65625
15.8046875
14
3.4765625
3.67578125
1.40625
1.40625

10029
16.47265625
10.625
13.8125
4.14453125
4.21484375
1.2421875
0.7265625

10031
12.46484375
12.65234375
11.84375
2.10546875
3.875
1.21875
1.1015625

10033
13.87109375
15.93359375
13.21484375
5.84375
5.09375
1.1015625
0.8671875

10034
12.69921875
13.84765625
9.16015625
0.8515625
2.609375
0.8203125
0.8203125

10035
10.390625
8.46875
7.84765625
4.35546875
2.85546875
1.3828125
1.03125

10037
14.46875
15.5234375
13.015625
4.19140625
4.58984375
1.546875
1.5

10038
12.265625
16.4375
14.4921875
3.79296875
5.69140625
1.1484375
0.65625

10040
11.59765625
10.98828125
17.03515625
6.37109375
5.75
1.1484375
0.6796875

10041
14.046875
8.1640625
9.98046875
3.25390625
3.21875
0.8671875
0.9375

10042
14.234375
14.69140625
10.3203125
4.16796875
3.3125
1.125
1.03125

10043
13.30859375
15.3359375
12.44140625
5.31640625
4.56640625
0.9609375
1.0546875

10045
13.2734375
12.0546875
9.40625
7.109375
5.7265625
0.984375
1.03125

10046
7.77734375
6.67578125
7.671875
2.3046875
1.90625
0.796875
1.1015625

10048
14.984375
21.37109375
14.97265625
8.57421875
8.64453125
1.9453125
1.640625

10049
11.4453125
11.328125
11.71484375
3.83984375
2.9140625
0.8671875
0.9375

10052
15.1953125
18.3359375
11.69140625
6.21875
4.49609375
1.359375
1.21875

10053
15.39453125
13.05078125
11.1171875
4.1328125
4.82421875
1.6875
1.1015625

10054
12.11328125
12.0078125
14.3515625
3.9453125
3.6875
0.890625
0.7734375

10055
13.28515625
9.04296875
12.76953125
7.54296875
6.734375
1.3359375
1.0546875

10058
11.69140625
9.5234375
11.1171875
4.42578125
3.04296875
1.734375
1.0546875

10062
14.4921875
12.30078125
12.0546875
4.109375
4.90625
1.1953125
0.796875

10064
12.9921875
14.45703125
14.80859375
5.73828125
5.421875
1.5234375
1.359375

10065
12.453125
6.51171875
9.1015625
4.12109375
5.48046875
1.03125
0.75

10069
15.76953125
14.50390625
14.8203125
5.90234375
6.18359375
2.296875
1.4296875

10070
9.8984375
8.99609375
10.77734375
2.45703125
15.96875
0.8203125
0.984375

10072
15.55859375
15.125
14.87890625
5.140625
3.60546875
1.3359375
0.9140625

10073
15.37109375
16.859375
20.57421875
7.5078125
46.75390625
4.03125
1.8984375

10074
11.1875
8.94921875
9.0078125
3.13671875
2.90234375
1.1015625
1.21875

10076
14.3515625
17.6328125
13.75390625
4.49609375
4.484375
2.0390625
1.171875

10078
19.21484375
14.7734375
15.2421875
6.078125
6.40625
1.875
1.1484375

10079
10.98828125
12.11328125
14.2109375
11.046875
5.22265625
2.2265625
1.9921875

10080
12.58203125
10.58984375
12.32421875
4.15625
19.30859375
0.8671875
0.4921875

10081
15.95703125
15.828125
18.55859375
7.4140625
5.24609375
1.4765625
1.0546875

10082
15.2890625
14.85546875
13.8359375
4.87109375
3.875
1.734375
0.515625

10083
10.89453125
10.6953125
10.33203125
4.15625
3.46484375
1.7109375
1.0546875

10084
14.65625
12.546875
12.20703125
4.8125
4.70703125
1.8046875
1.265625

10086
17.703125
17.234375
14.2578125
5.796875
4.28515625
0.84375
0.703125

10087
19.0625
26.41015625
19.47265625
7.23828125
7.40234375
1.2890625
0.796875

10089
12.5703125
11.64453125
10.6484375
5.03515625
8.2578125
1.96875
2.15625

CN + 75tPA dAmax
CN + 150tPA dAmax
CFF dAmax
CFF + TXA dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
CRT LY30
CN LY30

10017
0.890625
0.8671875
0.375
0.2578125
0.06030463
0.016644911

10019
1.1953125
1.125
1.5
0.703125
0.018560257
0.022788509

10020
0.890625
0.8203125
0.5390625
0.5390625
0.030007206
0.014039481

10021
0.703125
0.375
2.484375
1.03125
−0.069673728
−0.032943886

10022
0.8203125
1.0546875
0.9375
0.796875
0.015688864
0.01108298

10023
0.9375
0.46875
1.03125
1.1953125
0.050798564
0.02016465

10024
0.9140625
1.078125
0.515625
0.421875
0.051351544
0.03619448

10026
0.9375
0.8203125
0.1640625
0.140625
0.0408322
0.045881663

10028
1.40625
1.40625
0.84375
0.8671875
0.036332229
0.01844581

10029
0.609375
0.421875
0.8671875
0.8671875
0.04213007
0.013138143

10031
1.0078125
0.890625
1.1953125
0.46875
0.075543799
0.097434874

10033
0.8671875
0.8203125
0.796875
0.75
0.026377517
0.018340861

10034
0.6328125
0.6796875
0.5625
0.375
0.033425663
0.02512734

10035
0.9375
1.0546875
0.8203125
0.6328125
0.020279463
0.02175914

10037
1.5
1.5
0.8671875
0.7734375
0.030046405
0.021488548

10038
0.515625
0.609375
0.9140625
1.0546875
0.026372114
−0.001829025

10040
0.4453125
0.6796875
0.9609375
0.890625
0.04965042
0.028593531

10041
1.03125
0.8203125
0.6328125
0.5625
0.041559335
0.021645254

10042
1.1953125
1.265625
0.8671875
0.703125
0.028059636
0.027165333

10043
0.984375
1.0078125
0.5859375
0.6796875
0.019282548
0.021101822

10045
0.75
0.703125
1.171875
0.75
0.010444722
0.012927694

10046
1.1484375
1.125
0.421875
0.328125
0.020347299
0.019610932

10048
1.1015625
1.2421875
0.9609375
1.1484375
0.020143973
0.015210808

10049
0.9375
0.8671875
0.5390625
0.375
0.040608237
0.031604588

10052
1.3125
0.7265625
0.796875
0.5859375
0.017503627
0.013801031

10053
1.1953125
1.125
0.65625
0.6796875
0.011311864
0.015675281

10054
0.703125
0.75
0.421875
0.421875
0.054953929
0.027473823

10055
1.0546875
1.1953125
1.1484375
0.9375
0.015969118
0.017118432

10058
1.125
1.03125
0.6796875
0.4921875
0.029763752
0.026953488

10062
0.8671875
0.890625
0.703125
0.65625
0.021739726
0.016778287

10064
1.5234375
1.4765625
1.1015625
1.078125
0.026595224
0.023099733

10065
0.9609375
1.03125
0.9140625
0.8203125
0.018600233
0.025373115

10069
1.6171875
1.453125
0.9140625
0.8671875
0.013138008
0.011164596

10070
0.9609375
1.0078125
0.4453125
1.078125
0.022669018
0.016251562

10072
1.171875
1.1015625
0.46875
0.4921875
0.026998812
0.019600661

10073
2.203125
5.0859375
1.171875
3.1640625
0.032281957
0.033183973

10074
1.5703125
1.3125
0.5859375
0.5390625
0.024875899
0.031321629

10076
1.078125
0.9609375
0.6796875
0.609375
0.045710899
0.028091361

10078
1.171875
1.078125
1.171875
0.984375
0.03587902
0.036731083

10079
2.1796875
2.296875
2.953125
1.2421875
0.012896383
0.004602465

10080
0.8203125
0.7734375
0.515625
3.1171875
0.028764003
0.019558275

10081
1.171875
1.0078125
0.9375
0.5859375
0.03960892
0.020360281

10082
0.6796875
0.5625
0.4453125
0.46875
0.03400434
0.026273852

10083
1.40625
1.5703125
1.03125
0.6328125
0.02385182
0.019988301

10084
1.3125
1.3828125
0.9375
0.9140625
0.009423337
0.021685821

10086
0.75
0.609375
0.75
0.5859375
0.036625251
0.023212273

10087
0.9609375
0.6328125
0.5390625
0.8671875
0.024173361
0.017043544

10089
2.2265625
1.453125
1.1015625
2.15625
0.020497577
0.025572178

CN + 75tPA
CN + 150tPA

CFF + TXA

CN + 75tPA
CN + 150tPA

Patient ID
LY30
LY30
CFF LY30
LY30
CRT CL30
CN CL30
CL30
CL30

10017
0.081614091
0.569954211
−0.001500615
−0.048368991
0.883525708
0.958975634
0.768401438
0.002741604

10019
0.100859305
0.454886769
0.003487637
−0.009435011
0.957804934
0.950039651
0.691532258
0.013667768

10020
0.060452899
0.432118003
−0.003161484
−0.006205347
0.947320721
0.965350619
0.849068323
0.102351522

10021
−0.032157738
0.127611483
−0.006157125
−0.030527211
1.118334551
1.051256281
1.075
0.672909699

10022
0.011277198
0.026278403
0.04736335
0.043820077
0.962822854
0.970527592
0.967101828
0.933623225

10023
0.106925905
0.536037656
0.001784416
0.006433573
0.900829516
0.94966328
0.72179289
0.028103563

10024
0.432249981
0.633892143
0.02721235
0.135655746
0.900575288
0.918019386
0.019986496
0.003837609

10026
0.128821656
0.681686502
−0.007343165
−0.002573182
0.912031439
0.903495206
0.658717227
0.004701734

10028
0.070189301
0.48095455
−0.011132702
−0.006824796
0.936318165
0.970026942
0.773777413
0.004587775

10029
0.265292973
0.589190565
0.0284828
−0.018540186
0.911145474
0.962221156
0.398922273
0.00424854

10031
0.609129512
0.6387822
0.367293922
−0.005472394
0.79949463
0.741412336
0.002547771
0.003713159

10033
0.095054717
0.423588199
−4.86E−04
−0.002458642
0.949741781
0.956710465
0.732236753
0.125857275

10034
0.18634948
0.60229057
0.013688821
0.013426129
0.931203298
0.947183099
0.460087083
0.007767477

10035
0.0364523
0.300278285
−0.013139777
−0.010031109
0.953667954
0.953899793
0.904203178
0.145705267

10037
0.062978323
0.313275214
0.001045534
0.001356773
0.942470588
0.956468764
0.834579439
0.129564782

10038
0.002257233
0.024505653
−0.004964088
−0.005459318
0.934087113
0.988006397
0.985962264
0.952716144

10040
0.079753038
0.362801457
−0.003030418
−0.015363551
0.906372841
0.931478882
0.806022187
0.176519846

10041
0.072059274
0.468926949
0.01875384
0.003831169
0.914002642
0.943570199
0.799179168
0.114254144

10042
0.159310139
0.555088509
6.02E−04
0.007616406
0.939492032
0.943042626
0.521192876
0.002822865

10043
0.340209296
0.615954158
−0.004230896
−0.006153312
0.954517211
0.947644618
0.184936401
0.004690832

10045
0.233396854
0.717038532
−0.026521072
−0.031434025
0.975311721
0.969577047
0.378203049
0.004873591

10046
0.229340172
0.645899307
−0.015154296
−0.010567847
0.953309228
0.952947766
0.37218845
0.003958436

10048
0.060154171
0.495028192
0.013921412
0.010570533
0.950428781
0.969546368
0.82712829
0.027286649

10049
0.075264933
0.473617858
7.89E−04
0.004389299
0.911823381
0.92887447
0.805864937
0.016139141

10052
0.157126695
0.32081578
−0.006094217
−0.007797413
0.956909684
0.972984992
0.563337606
0.26097561

10053
0.046222991
0.305119209
−0.011028306
−0.012549685
0.972473785
0.96362138
0.874260541
0.198237288

10054
0.167679483
0.604487059
0.017146639
0.007753048
0.889998686
0.934306569
0.543710351
0.00300075

10055
0.101571797
0.302263169
−0.002832652
−0.012365396
0.960823529
0.956111373
0.729655396
0.224957686

10058
0.492045474
0.728459911
0.010215637
0.009807596
0.934421805
0.93461794
0.015826675
0.003833253

10062
0.018351097
0.420841429
5.95E−04
−0.006456804
0.955436275
0.960178593
0.957121735
0.065704067

10064
0.078911616
0.501083179
5.00E−04
0.003245918
0.945577501
0.952060007
0.756800344
0.004366812

10065
0.662967521
0.860495292
−0.003749847
−0.016334626
0.956045461
0.947290773
0.002540489
0.003531229

10069
0.068198674
0.405900722
−0.021435512
−0.05345696
0.968898951
0.978569037
0.781553398
0.068803753

10070
0.166666052
0.620378916
0.027281701
0.026450448
0.955101384
0.963042314
0.493874539
0.003725656

10072
0.100680595
0.428920697
−0.005763529
0.001426519
0.937938168
0.952942607
0.690566499
0.006970128

10073
0.030185044
0.277177537
0.0096862
0.963302857
0.928463039
0.927038173
0.920555676
0.259249109

10074
0.480037116
0.733005689
0.043781786
0.007443196
0.937417099
0.921170912
0.017798947
0.002438281

10076
0.164391319
0.455341226
0.015017479
0.009141971
0.910869299
0.940808129
0.53002611
0.096232339

10078
0.051553756
0.569544199
0.005193271
0.007651688
0.927206135
0.920553501
0.851969909
0.002389129

10079
0.445629052
0.813086048
−0.057418699
−0.009947183
0.970925699
0.996073727
0.007710899
0.035209942

10080
0.224187202
0.704488199
0.030031525
−0.024219533
0.934737136
0.95048951
0.304102423
0.003391986

10081
0.024098689
0.183163642
0.006851246
0.018016738
0.918197183
0.949680511
0.948804272
0.434383528

10082
0.028358471
0.054769895
−0.160043689
−0.015227126
0.924934536
0.945744681
0.941184827
0.858544443

10083
0.277498451
0.702136449
0.020317892
0.010942952
0.945607252
0.953371772
0.251805855
0.002266289

10084
0.224975897
0.606549884
0.018206383
0.00716612
0.970905966
0.946845445
0.3472
0.0021748

10086
0.025188655
0.276866049
−0.109540649
−0.524623741
0.932175155
0.947470112
0.945094622
0.358550969

10087
0.044756847
0.265357348
−0.111567441
−0.048439778
0.95302088
0.964453308
0.880506092
0.307356444

10089
0.048802507
0.569068155
−0.004630295
0.004302772
0.950468211
0.941240126
0.836213803
0.002083062

CFTX dV @ CFF max
CN dV @ CN + tPA75 max
CRT dA Integration to Acrit

Patient ID
CFF CL30
CFF + TXA CL30
(mm/min)
(mm/min)
(mm{circumflex over ( )}2)

10017
1
1.199683043
0
0.28125
21.30633545

10019
0.983984265
1.018192844
0.28125
0.5625
31.7411499

10020
1.00589198
1.015070328
0
0.140625
24.37976074

10021
1.015485687
1.071020408
0.140625
−0.140625
1.959411621

10022
0.90119131
0.909774436
0.28125
0.140625
8.127685547

10023
0.993456132
0.987755102
0
0.140625
146.5043335

10024
0.933497537
0.966793893
0.28125
0.421875
7.781616211

10026
1.001685393
0.996600567
0
0.421875
83.27911377

10028
1.014414924
1.010477299
0
0.140625
14.05371094

10029
0.917003419
1.042654028
0.140625
0.84375
87.20123291

10031
0.128238767
1.015619915
0.421875
0.984375
161.4298096

10033
1
1.012568482
0.140625
0.421875
15.75604248

10034
0.977255497
0.978956598
0.140625
0.84375
88.0713501

10035
1.018706157
1.016679905
0.140625
0.421875
20.97674561

10037
0.993502475
0.994298385
0
0.28125
20.60925293

10038
1.007125891
1.011338583
0.140625
0
46.12445068

10040
1.006355932
1.052509908
0
0.28125
73.39471436

10041
0.950239587
0.99109462
0.140625
0.421875
6.969177246

10042
1
0.99454347
0
0.421875
22.359375

10043
1.008300395
1.020230067
−0.140625
0.5625
31.41156006

10045
1.060284678
1.070204351
−0.140625
0.5625
110.9465332

10046
1.024469821
1.015929204
0
0.28125
4.541748047

10048
0.96672418
0.980969642
0.140625
0.28125
105.1243286

10049
0.992842942
0.990877498
0
0.28125
130.3511353

10052
1.011964108
1.014350252
0
0.28125
80.39025879

10053
1.016435707
1.02285525
0
0.140625
19.06677246

10054
0.973808658
0.992242335
0.140625
0.421875
106.6256104

10055
1.004087193
1.023573923
0
0.28125
76.30169678

10058
0.976147452
0.982008996
0.140625
0.703125
27.76794434

10062
1.011977887
1.016278327
0
0.140625
10.21893311

10064
1.018669528
0.999329009
−6.00E−15
0.140625
78.70770264

10065
1.005516734
1.029619182
0
1.265625
41.66015625

10069
1.087039046
1.212637363
−0.140625
0.140625
47.99816895

10070
0.95382526
0.947709163
0.140625
0.421875
11.39886475

10072
1.015567087
1.001055595
−0.140625
0.28125
169.7272339

10073
0.983117201
0.001582806
2.109375
0
266.918335

10074
0.867339022
0.99428789
0.140625
0.703125
13.6137085

10076
0.967523681
0.987967914
0.28125
0.5625
42.14959717

10078
0.998309859
0.991973841
0.140625
0.28125
104.5129395

10079
1.164487805
1.018108652
0.140625
0.5625
40.72576904

10080
0.944753747
1.316089226
0.140625
0.984375
80.52703857

10081
0.981234006
0.962223587
0.140625
0.140625
273.0470581

10082
1.481165049
1.103191048
0
0.140625
28.32495117

10083
0.961801242
0.988485694
0.140625
0.28125
34.64154053

10084
0.976790831
0.99552506
0.140625
0.140625
100.7177124

10086
1.363609291
2.398410175
0.28125
0.140625
128.4246826

10087
1.343873518
1.18296893
−0.140625
0.28125
138.6172485

10089
1.024151811
0.996706012
0.140625
0.140625
53.89782715

CN dA Integration to Acrit
CN + 75tPA dA Integration to Acrit
CN + 150tPA dA Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10017
94.42584229
128.0390625
101.446106

10019
176.0718384
131.9265747
77.90844727

10020
108.4432983
107.7000732
88.54925537

10021
10.69354248
22.64941406
6.423706055

10022
89.33532715
71.53582764
119.2175903

10023
175.1193237
96.00292969
48.77600098

10024
66.48486328
171.0027466
99.48999023

10026
72.15545654
69.8104248
50.5178833

10028
177.543457
192.3255615
163.6281738

10029
108.4235229
49.97900391
52.5201416

10031
104.6365356
95.62884521
86.88647461

10033
107.480896
101.4098511
85.96856689

10034
91.47601318
77.46844482
49.8883667

10035
93.51123047
68.41296387
68.36846924

10037
194.5535889
209.1115723
169.8145752

10038
64.14477539
73.65673828
75.53210449

10040
60.17816162
37.54193115
100.8495483

10041
111.1772461
30.91552734
69.57476807

10042
139.6043701
149.2036743
113.6920166

10043
120.5161743
126.173584
105.0518188

10045
121.7636719
73.59741211
55.30517578

10046
76.05780029
48.24041748
76.40222168

10048
179.8571777
184.911438
147.2590942

10049
96.63244629
91.41833496
94.50164795

10052
158.8392334
190.2095947
46.33209229

10053
161.8994751
101.8580933
103.1022949

10054
81.1038208
66.59692383
82.92810059

10055
120.0481567
55.00360107
129.8139038

10058
110.1373901
89.20019531
79.67834473

10062
93.27392578
81.41363525
100.6468506

10064
116.4210205
205.6195679
207.8245239

10065
77.69421387
48.6260376
74.17749023

10069
197.9401245
188.4710083
182.1873779

10070
91.3392334
58.20062256
104.883728

10072
128.9833374
158.1075439
152.0348511

10073
257.6453247
311.8577979
98.69732666

10074
120.9594727
96.13311768
108.487793

10076
142.8343506
103.7120361
111.0997925

10078
177.0441284
124.2784424
139.541748

10079
186.0320435
230.6552124
201.6463623

10080
36.67181396
79.13616943
87.91644287

10081
143.079895
147.1552734
149.0718384

10082
68.89086914
87.04962158
64.06237793

10083
100.2694702
137.142334
149.5794067

10084
178.5157471
151.3707275
155.8811646

10086
100.1524658
110.9432373
68.44262695

10087
140.5206299
191.46698
111.8084106

10089
196.9431152
151.2372437
114.6115723

CFF dA
CFF + TXA dA

Integration to Acrit
Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
ID
SBP
HR
OR?
ICU?
Death?
pRBC
FFP
PLT

10017
12.61669922
9.226867676
10017
80
116
Yes
Yes
No
0
0
0

10019
14.46240234
28.41064453
10019
86
90
Yes
Yes
No
0
0
0

10020
21.8897D947
22.59503174
10020
136
100
Yes
0
No
0
0
0

10021
57.74084473
9.508666992
10021
80
103
Yes
0
No
0
0
0

10022
8.803344727
6.862060547
10022
138
88
No
Yes
No
0
0
0

10023
45.24279785
76.33795166
10023
106
120
Yes
0
No
0
0
0

10024
17.62646484
8.737426758
10024
150
108
Yes
Yes
No
0
0
0

10026
0.278503418
1.496337891
10026
116
100
Yes
Yes
No
0
0
1

10028
24.4588623
26.37213135
10028
102
100
No
Yes
No
0
0
0

10029
30.09979248
31.25994873
10029
62
120
Yes
Yes
No
0
0
0

10031
1.105773926
15.78076172
10031
Uto
Uto
Yes
Yes
No
0
0
0

10033
42.42150879
34.27734375
10033
110
94
Yes
Yes
No
0
0
0

10034
3.371704102
7.218017578
10034
140
100
Yes
Yes
No
0
0
0

10035
34.21307373
14.93206787
10035
80
70
Yes
Yes
No
0
0
0

10037
34.14385986
33.68243408
10037
180
120
No
Yes
No
0
0
0

10038
30.17559814
40.28082275
10038
128
120
Yes
Yes
No
0
0
0

10040
53.66217041
27.57348633
10040
162
108
No
0
No
0
0
0

10041
18.02032471
15.65222168
10041
88
70
Yes
Yes
No
0
2
1

10042
24.84283447
19.11621094
10042
100
90
Yes
Yes
No
0
0
0

10043
29.10772705
26.66546631
10043
90
60
Yes
Yes
No
0
0
0

10045
70.72998047
37.99841309
10045
100
58
No
Yes
Yes
0
0
0

10046
7.864013672
5.115234375
10046
130
90
No
0
No
0
0
0

10048
56.56915283
80.21722412
10048
88
112
No
0
No
0
0
0

10049
16.1416626
9.149414062
10049
Walk-in
Walk-in
No
0
No
0
0
0

10052
34.28393555
21.70184326
10052
100
100
Yes
Yes
No
0
0
0

10053
20.61584473
28.09588623
10053
116
110
Yes
Yes
No
0
0
0

10054
15.07543945
13.2989502
10054
108
124
Yes
Yes
No
0
0
0

10055
59.88153076
55.71386719
10055
136
78
No
Yes
No
0
0
0

10058
26.85992432
11.59661865
10058
118
110
Yes
Yes
No
0
0
0

10062
23.73046875
25.08178711
10062
86
60
No
0
No
0
0
0

10064
56.35821533
51.12597656
10064
118
72
No
0
No
0
0
0

10065
31.25335693
38.93609619
10065
140
120
No
Yes
No
0
0
0

10069
48.08880615
39.92816162
10069
90
140
Yes
Yes
No
0
0
0

10070
8.679748535
20.0291748
10070
160
92
Yes
0
No
0
0
0

10072
17.0859375
14.16412354
10072
Unk
Unk
No
0
No
0
0
0

10073
62.96813965
963.953064
10073
156
114
Yes
Yes
No
0
0
0

10074
11.56365967
13.36651611
10074
81
100
Yes
Yes
No
0
0
0

10076
26.94232178
20.18408203
10076
170
60
Yes
Yes
No
0
0
1

10078
59.2701416
55.34472656
10078
96
60
Yes
Yes
No
0
0
0

10079
238.847168
49.64117432
10079
82
112
No
Yes
No
0
0
0

10080
15.51708984
96.45941162
10080
98
112
No
0
No
0
0
0

10081
61.43225098
24.95159912
10081
Walk-in
Walk-in
Yes
Yes
No
0
0
0

10082
18.13897705
11.51916504
10082
138
120
No
0
No
0
0
0

10083
38.19287109
19.47052002
10083
142
70
Yes
Yes
No
0
0
0

10084
42.3951416
29.05499268
10084
170
104
No
Yes
No
0
0
0

10086
35.31884766
18.47186279
10086
100
120
Yes
0
No
0
0
0

10087
32.47283936
53.8895874
10087
162
120
No
0
No
0
0
0

10089
50.00042725
125.1551514
10089
120
80
Yes
Yes
No
0
0
0

Patient ID
CRYO
CN Crit Prod

10017
0
10.65591431

10019
0
19.26974487

10020
0
14.20358276

10021
0
1.299224854
All tubes clotted

10022
0
10.35644531

10023
0
19.7460022

10024
0
7.946777344

10026
0
8.667755127

10028
0
20.61035156

10029
0
11.96841431

10031
0
13.73080444

10033
0
12.02883911

10034
0
10.41732788

10035
0
10.71533203

10037
0
21.703125

10038
0
8.049316406

10040
0
7.882781982

10041
0
13.16894531

10042
0
14.67919922

10043
0
14.03640747

10045
0
13.68823242

10046
0
8.567230225

10048
0
24.58374023

10049
0
10.72998047

10052
0
18.51928711

10053
0
16.95803833

10054
0
9.368865967

10055
0
14.01168823

10058
0
12.33078003

10062
0
11.54846191

10064
0
17.66125488

10065
0
9.33984375

10069
0
22.54550171

10070
0
9.743774414

10072
0
14.2215271

10073
0
29.18106079

10074
0
13.63476563

10076
0
16.8182373

10078
0
22.06704712

10079
0
21.89071655

10080
0
6.192718506

10081
0
16.8296814

10082
0
7.883422852

10083
0
11.49032593

10084
0
18.54931641

10086
0
12.44750977

10087
0
15.19042969

10089
0
27.10473633

CRT Amax
CN Amax
CN + 75tPA Amax
CN + 150tPA Amax
CFF Amax
CFF + TXA Amax
CRT Acrit

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10092
67.90625
69.7578125
68.9140625
61.765625
21.40625
21.2890625
17.76171875

10094
64.671875
65.0703125
63.03125
58.7421875
26.1640625
24.8046875
2.48046875

10096
63.640625
65.1875
64.7421875
65.1875
24.6171875
24.8984375
18.40625

10098
59.703125
66.171875
62.5625
61.625
19.296875
19.953125
1.84765625

10100
66.734375
71.65625
67.6015625
54.125
26.0703125
26.65625
2.29296875

10101
63.0546875
66.6640625
64.1328125
55.25
24.3359375
24.3359375
2.1640525

10103
66.4296875
68.46875
63.7109375
45.484375
28.390625
26.65625
10.51953125

10105
56.7734375
60.4296875
62.140625
52.203125
26.5625
24.5
1.84765625

10108
52.2265625
65.375
58.765625
59
20.2578125
18.734375
1.35546875

10109
62.8671875
66.3828125
63.546875
58.8359375
24.359375
24.0546875
2.66796875

10110
65.84375
64.15625
66.78125
65.5625
22.7890625
21.9921875
1.6953125

10111
67.6015625
73.5078125
71.1875
68.6796875
26.6328125
26.65625
15.5703125

10112
82.1328125
62.5625
60.03125
54.4765625
29.2578125
0.125
11.8203125

10113
50.3046875
48.125
28.6015625
23.5625
15.9921875
14.65625
11.375

CN Arit
CN + 75tPA Acrit
CN + 150tPA Acrit
CFF Acrit
CFF + TXA Acrit
CRT dAmax
CN dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10092
16.859375
16.70703125
14.65625
3.76953125
3.72265625
0.9609375
0.9375

10094
12.828125
14.29296875
15.53515625
6.25390625
6.21875
2.2734375
1.125

10096
16.15625
13.9765625
13.75390625
3.67578125
4.71875
0.984375
1.03125

10098
6.41796875
7.09765625
8.19921875
1.56640625
2.19921875
1.1953125
1.4296875

10100
13.15625
16.82421875
16.765625
4.390625
5.7734375
1.7578125
1.265625

10101
10.1796875
10.4609375
8.78515625
4.109375
3.91015625
1.40625
1.453125

10103
11.26953125
9.9453125
8.38671875
4.4375
27.875
1.3828125
1.4296875

10105
14.328125
15.18359375
12.8515625
5.609375
4.96484375
1.6640625
0.9375

10108
9.640625
10.15625
8.3515625
1.390625
2.0703125
0.9140625
1.3125

10109
14.10546875
9.7578125
10.49609375
2.92578125
3.72265625
1.8515625
1.1953125

10110
11.41015625
9.41796875
10.2734375
3.546875
3.359375
1.828125
1.0546875

10111
13.90625
11.8203125
14.84375
4.578125
4.89453125
1.78125
1.734375

10112
19.7890625
17.75
16.6953125
5.65625
0.16015625
3.84375
0.75

10113
14.57421875
12.0546875
0.359375
11.22265625
1.7890625
0.703125
0.3515625

CN + 75tPA dAmax
CN + 150tPA dAmax
CFF dAmax
CFF + TXA dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
CRT LY30
CN LY30

10092
1.0546875
1.125
0.5390625
0.6328125
0.02308093
0.009447213

10094
1.0546875
1.1015625
1.0078125
0.890625
0.029986443
0.02516742

10096
1.03125
1.1015625
0.5390625
0.609375
0.02673739
0.023091276

10098
1.3359375
1.2421875
0.5390625
0.3984375
0.028060208
0.025009675

10100
1.0078125
0.984375
0.65625
0.703125
0.032283943
0.019990945

10101
1.359375
1.3828125
0.9375
0.8203125
0.023396867
0.017267276

10103
1.3125
0.7265625
1.125
1.921875
0.019735192
0.020560912

10105
1.2421875
1.453125
0.75
0.6796875
0.0298312
0.028208719

10108
1.359375
1.5
0.65625
0.375
0.021454126
0.024958008

10109
1.640625
1.3828125
0.8203125
0.7265625
0.022353396
0.012313169

10110
1.3359375
1.40625
0.84375
0.75
0.022358013
0.020903184

10111
1.734375
1.96875
1.078125
0.8203125
0.022739705
0.01260451

10112
0.5625
0.84375
0.890625
0.0703125
0.879012492
0.027216533

10113
0.234375
0.46875
4.1015625
0.28125
0.046618911
0.009909361

CN + 75tPA
CN + 150tPA

CFF + TXA

CN + 75tPA
CN + 150tPA

Patient ID
LY30
LY30
CFF LY30
LY30
CRT CL30
CN CL30
CL30
CL30

10092
0.061420505
0.423262923
−1.74E−04
−0.029998471
0.95478601
0.973457274
0.8234894
0.033898305

10094
0.093868782
0.476873587
−0.017023738
−0.002700787
0.938390916
0.947052467
0.704015865
0.025269318

10096
0.022254736
0.04494031
0.002878275
−8.86E−04
0.94254849
0.94822627
0.946060094
0.883149569

10098
0.019210477
0.024390248
−0.011732456
−0.002473245
0.940722324
0.950413223
0.95467033
0.951698783

10100
0.064302843
0.563915151
−0.011968085
−0.023366468
0.93889019
0.960423027
0.812434994
0.002742494

10101
0.079153977
0.54122007
−0.005733012
−0.005837346
0.953537356
0.957810852
0.764648556
0.003959276

10103
0.068618434
0.441085434
0.011639684
−9.79E−04
0.955545102
0.951049749
0.800613121
0.050084034

10105
0.241447525
0.672740198
0.004960784
−0.00922619
0.934773634
0.940271493
0.317701785
0.002394493

10108
0.562259963
0.618193856
0.022240969
0.017528496
0.949289454
0.946223709
0.002127094
0.002118644

10109
0.035683892
0.524804696
−0.006783194
−2.86E−04
0.955635641
0.967517948
0.890828621
0.002124552

10110
0.021046184
0.180870505
0.016776178
0.009773535
0.940199336
0.954335119
0.955077211
0.406577693

10111
0.021232989
0.247648005
−0.016114207
−0.018321366
0.955622328
0.96779679
0.955553117
0.240700717

10112
0.072425928
0.479522205
0.002217401
0
0.001807286
0.932567433
0.805960437
0.014771261

10113
0.266667805
0.752061229
0.024084025
0.009252843
0.902624631
0.960064935
0.328871893
0.00530504

CFTX dV @ CFF max
CN dV @ CN + tPA75 max
CRT dA Integration to Acrit

Patient ID
CFF CL30
CFF + TXA CL30
(mm/min)
(mm/min)
(mm{circumflex over ( )}2)

10092
1.048175182
1.153027523
0.140625
0.28125
155.1560669

10094
1.058226336
1.009448819
0
0.703125
41.04217529

10096
1.012377023
1.001882648
0.140625
0.28125
137.9168701

10098
1.025506073
1.002349256
−0.140625
0.140625
18.10931396

10100
1.042253521
1.110785463
0
0.28125
30.77545166

10101
1.013483146
1.009630819
0.140625
0.28125
24.70935059

10103
0.987616951
1.175849941
0.140625
0.140625
148.2346802

10105
0.990294118
1.015306122
0.140625
0.28125
21.95892334

10108
0.952564597
0.962468724
0.140625
0.703125
9.876159668

10109
1.011545863
1.000974342
−0.140625
0.140625
41.13446045

10110
0.977374014
0.988277087
0.28125
0.140625
19.80834961

10111
1.036960986
1.055392732
0
0.140625
248.6063232

10112
0.999198932
1
0
0.140625
332.9483643

10113
0.935515388
0.984008529
−0.140625
0.5625
74.6619873

CN dA Integration to Acrit
CN + 75tPA dA Integration to Acrit
CN + 150tPA dA Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10092
153.1142578
148.8806763
155.2236328

10094
112.9405518
119.8833618
155.0736694

10096
152.5968018
114.3511963
138.5315552

10098
85.04241943
88.23614502
99.55096436

10100
142.5476074
103.4598999
133.3125

10101
126.7272949
113.6920166
106.6964722

10103
139.7114868
101.5993652
47.87127686

10105
119.911377
157.7796021
169.5179443

10108
112.7658691
135.2076416
114.6643066

10109
152.0645142
124.2454834
133.0438843

10110
116.5907593
93.62493896
127.8973389

10111
218.4060059
173.4334717
267.8873291

10112
130.4747314
66.29699707
118.8896484

10113
36.29608154
14.78869529
0.046142578

CFF dA
CFF + TXA dA

Integration to Acrit
Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
ID
SBP
HR
OR?
ICU?
Death?
pRBC
FFP
PLT

10092
14.43109131
20.99981689
10092
210
128
No
0
No
0
0
0

10094
54.3147583
50.6184082
10094
128
100
Yes
Yes
No
0
0
0

10096
17.31170654
22.05615234
10096
100
96
Yes
Yes
No
0
0
0

10098
6.07598877
8.37322998
10098
108
112
No
Yes
No
0
0
0

10100
24.56433105
35.33862305
10100
Unk
Unk
Yes
0
No
0
0
0

10101
35.62536621
27.97064209
10101
110
110
Yes
0
No
0
0
0

10103
44.81103516
134.5023193
10103
123
92
No
0
No
0
0
0

10105
29.953125
20.06707764
10105
0
0
Yes
Yes
No
0
0
0

10108
8.041992187
7.827758789
10108
150
90
No
Yes
No
0
0
0

10109
18.23126221
18.26751709
10109
92
110
Yes
Yes
No
0
2
0

10110
25.58605957
21.515625
10110
100
92
Yes
Yes
No
0
0
0

10111
41.30090332
29.56256104
10111
115
70
No
Yes
No
0
0
0

10112
39.0135498
0.014831543
10112
210
142
No
Yes
No
0
0
0

10113
11.96575928
3.978149414
10113
110
110
No
Yes
No
0
0
0

Patient ID
CRYO
CN Crit Prod

10092
0
15.80566406

10094
0
14.43164063

10096
0
16.66113281

10098
0
9.175689697

10100
0
16.65087891

10101
0
14.7923584

10103
0
16.11190795

10105
0
13.43261719

10108
0
12.65332031

10109
0
16.86044312

10110
0
12.03414917

10111
0
24.11865234

10112
0
14.84179688

10113
0
5.123748779

TABLE 5

CRT Amax
CN Amax
CN + 75tPA Amax
CN + 150tPA Amax
CFF Amax
CFF + TXA Amax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10027
55.7421875
58.625
43.1328125
19.3203125
19.015625
16.859375

10036
44.75
28.953125
5.703125
4.578125
11.703125
13.578125

10013
40.671875
42.9453125
18.0546875
13.203125
18.21875
17.9140625

10099
31.0859375
10.7421875
3.2421875
0.921875
9.96875
5.9609375

10107
52.3203125
42.734375
30.9453125
22.6484375
16.0390625
16.5546875

10093
51.125
54.8984375
40.5546875
26.3046875
12.3828125
13.6484375

10044
21.6171875
20.984375
14.0703125
2.1171875
4.5546875
9.453125

10068
47.84375
48.3359375
33.03125
16.9296875
7.4140625
10.8359375

10030
61.2265625
64.5078125
47.2578125
33.59375
22.015625
23.421875

10077
52.6015625
55.484375
51.0546875
40.765625
16.2265625
15.8046875

10075
46.203125
53.421875
44.8671875
27.6640625
21.0078125
19.7421875

10090
46.671875
45.6171875
31.859375
19.15625
9.0546875
10.203125

10059
60.6875
55.5546875
41.4453125
30.265625
15.1953125
18.03125

10061
52.8359375
58.7421875
55.15625
33.9921875
23.3046875
22.2734375

10097
50.5859375
56.7265625
52.6953125
32.1171875
19.1328125
16.8828125

10025
62.234375
70.203125
64.4375
51.8984375
22.765625
23.1640625

10050
53.4453125
59.8671875
53.9375
32.9609375
19.9765625
18.921875

10060
61.7890625
46.2734375
54.5
38.1171875
23
15.1484375

10032
59.7734375
61.6953125
52.6015625
45.9921875
20.9140625
19.4140625

10106
33.5
36.5
30.40625
12.453125
6.875
6.546875

10063
48.59375
64.7890625
63.3828125
53.375
23.0234375
21.640625

10088
63.5
59.984375
60.8046875
49.9296875
20.6796875
20.5625

10102
55.25
61.34375
48.4765625
22.6953125
10.71875
11.0703125

10115
72.5703125
70.5546875
68.7734375
51.5
27.8046875
27.640625

10014
62.515625
65.0234375
62.3046875
49.578125
18.640625
22.3671875

10085
64.0390625
69.453125
65.9609375
58.3671875
21.8984375
21.7109375

10047
62.703125
69.171875
61.015625
42.3828125
23.8203125
24.59375

10051
66.078125
68.65625
66.1015625
38.2109375
25.15625
24.078125

10056
61.859375
70.6015625
58.90625
52.4609375
25.578125
28.4609375

10057
67.5078125
68.1640625
64.15625
57.03125
25.6015625
26.46875

10039
65.09375
67.1796875
62.84375
56.2109375
21.96875
22.0859375

10067
58.484375
61.1328125
52.7890625
44.609375
22.203125
21.8046875

10071
55.2265625
56.703125
0.125
19.9765625
14.234375
13.390625

10104
64.4609375
68
64.0859375
65.6796875
27.171875
26.234375

10001
56.84375
55.625
52.2265625
41.75
21.1953125
20.28125

10002
63.03125
64.2734375
63.921875
58.203125
26.28125
25.578125

10003
66.6875
67.53125
60.8046875
44.6796875
26.2578125
25.0859375

10004
46.203125
34.203125
22.7890625
16.6015625
14.9609375
20.984375

10005
56.5625
60.359375
58.7890625
47.796875
27.5234375
26.2578125

10006
63.8515625
62.2109375
59.0234375
39.4765625
23.7265625
23.4921875

10007
61.953125
65.5625
59.3515625
52.296875
35.75
25.0625

10008
70.1796875
60.734375
48.5703125
35.703125
32.46875
27.640625

10009
71.5390625
70.4375
65.9609375
48.828125
29.5859375
29.2109375

10010
59.046875
61.5078125
57.7109375
48.7578125
21.875
21.2890625

10011
68.4453125
66.03125
59.1640625
54.3828125
25.296875
24.5703125

10012
52.015625
46.7890625
32.4453125
26.5625
17.7734375
19.53125

10015
68.6796875
69.359375
64.5078125
54.8984375
27.5
25.6953125

10017
59.5625
62.84375
58.6953125
45.59375
21.171875
19.71875

CRT Acrit
CN Arit
CN + 75tPA Acrit
CN + 150tPA Acrit
CFF Acrit
CFF + TXA Acrit

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10027
0.86328125
9.69921875
11.890625
7.44921875
1.49609375
1.53125

10036
1.25
10.75390625
2.7265625
3.67578125
1.61328125
1.56640625

10013
1.73046875
8.515625
7.578125
6.21875
4.1328125
4.390625

10099
0.76953125
6.6640625
2.0703125
0.2421875
0.6875
0.23046875

10107
1.625
7.07421875
9.37109375
7.61328125
1.37890625
2.234375

10093
1.53125
10.0390625
9.04296875
8.515625
1.26171875
1.0859375

10044
0.59375
6.16015625
2.80859375
1.54296875
0.359375
1.484375

10068
12.48828125
13.0859375
6.58203125
8.66796875
0.3125
32.9140625

10030
1.8359375
12.7578125
12.41796875
13.7890625
5.4453125
4.37890625

10077
1.82421875
8.0703125
5.50390625
6.18359375
1.015625
1.0390625

10075
3.04296875
5.3515625
7.015625
6.60546875
3.8984375
3.23046875

10090
5.05859375
9.83984375
9.3359375
6.51171875
1.15625
0.359375

10059
1.16796875
15.3359375
13.63671875
13.63671875
2.38671875
2.01171875

10061
15.78125
14.140625
11.84375
12.1015625
4.671875
5.1875

10097
1.16796875
9.4296875
7.77734375
8.140625
3.3828125
1.015625

10025
1.9296875
10.26171875
12.81640625
9.58203125
4.4140625
3.41796875

10050
12.03125
9.98046875
9.8984375
8.76171875
2.3984375
2.515625

10060
1.7890625
5.66796875
14.796875
10.4609375
4.16796875
3.69921875

10032
12.76953125
13.14453125
12.6640625
13.625
3.3828125
2.64453125

10106
0.9921875
4.84765625
5.234375
3.7578125
0.40625
0.4296875

10063
1.35546875
9.46484375
7.7890625
8.48046875
2.41015625
2.22265625

10088
13.51953125
16.61328125
16.015625
14.8671875
39.0546875
3.34765625

10102
14.0703125
12.6875
12.18359375
8.62109375
26.78515625
0.37109375

10115
12.91015625
17.87890625
17.328125
16.8125
4.16796875
4.23828125

10014
1.7421875
10.37890625
9.7578125
13.47265625
3.4765625
3.9921875

10085
1.68359375
13.16796875
12.27734375
13.4609375
4.07421875
4.40234375

10047
10.44921875
13.296875
13.19140625
13.6484375
5.421875
4.37890625

10051
2.0703125
14.26953125
15.1484375
14.57421875
5.55078125
4.25

10056
2.9609375
10.66015625
10.25
12.67578125
3.95703125
6.2890625

10057
3.2421875
11.65625
10.91796875
11.52734375
4.44921875
5.7265625

10039
2.38671875
12.875
9.6171875
10.28515625
1.6015625
2.99609375

10067
16.5546875
12.3359375
11.5859375
12.62890625
43.54296875
3.5703125

10071
0.79296875
9.3125
0.125
9.265625
2.3046875
2.046875

10104
2.890625
11.73828125
9.81640625
10.91796875
5.421875
4.91796875

10001
1.73046875
13.00390625
13.96484375
9.8046875
3.3828125
2.984375

10002
17.9375
14.3984375
12.34765625
12.95703125
3.93359375
4.47265625

10003
6.0546875
16.015625
15.16015625
14.0703125
6.3828125
6.1015625

10004
0.828125
16.25
10.51953125
5.234375
2.9609375
1.16796875

10005
1.3203125
11.84375
11.83203125
11.15234375
2.41015625
1.625

10006
1.8828125
14.97265625
13.80078125
10.390625
4.42578125
4.859375

10007
2.140625
11.84375
8.94921875
12.65234375
14.17578125
4.390625

10008
6.11328125
14.10546875
18.55859375
15.34765625
8.9609375
6.8046875

10009
8.55078125
19.51953125
21.13671875
15.55859375
5.03515625
6.453125

10010
34.51953125
10.42578125
12.91015625
10.3671875
4.82421875
3.13671875

10011
8.71484375
13.05078125
13.40234375
13.70703125
5.31640625
5.22265625

10012
1.7421875
12.03125
9.58203125
11.15234375
2.0234375
1.96484375

10015
1.77734375
14.97265625
16.00390625
14.22265625
6.265625
5.36328125

10017
1.96484375
13.77734375
15.2421875
13.02734375
3.78125
3.65234375

CRT dAmax
CN dAmax
CN + 75tPA dAmax
CN + 150tPA dAmax
CFF dAmax
CFF + TXA dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10027
0.7734375
1.0078125
0.9375
0.8203125
0.8203125
0.28125

10036
1.078125
0.4921875
0.1875
0.1640625
1.1015625
0.2578125

10013
1.1484375
0.5625
0.515625
0.609375
0.5625
0.421875

10099
0.5390625
0.140625
0.09375
0.046875
0.515625
0.1171875

10107
0.795875
0.4453125
0.5859375
0.7265625
0.7265625
0.46875

10093
0.84375
0.84375
0.8203125
0.84375
0.3515625
0.234375

10044
0.421875
0.3046875
0.3515625
0.0703125
0.1875
0.28125

10068
0.4921875
0.515625
0.5859375
0.4921875
0.140625
0.140625

10030
1.171875
1.40625
1.4765625
1.3125
0.796875
0.8671875

10077
1.5703125
0.9375
1.0546875
1.2421875
0.703125
0.65625

10075
1.7578125
1.03125
1.078125
1.0546875
0.75
0.6328125

10090
0.5390625
0.4921875
0.46875
0.4921875
0.140625
0.234375

10059
1.0078125
0.703125
0.7265625
0.6796875
0.2578125
0.2109375

10061
1.545875
1.078125
1.125
0.984375
0.796875
0.65625

10097
0.9140625
0.9375
1.1953125
0.890625
1.03125
0.703125

10025
1.734375
1.6640625
1.6171875
1.6640625
0.9375
0.9609375

10050
0.75
1.0546875
1.078125
1.0078125
0.515625
0.421875

10060
1.734375
0.3046875
0.890625
0.984375
0.7734375
0.3046875

10032
1.0546875
1.0546875
1.078125
1.078125
0.703125
0.5859375

10106
0.5625
0.3984375
0.375
0.421875
0.140625
0.234375

10063
1.0078125
1.1953125
1.125
1.1953125
0.4453125
0.3515625

10088
0.8671875
0.6328125
0.65625
0.703125
0.5625
0.3515625

10102
0.515625
0.65625
0.5859375
0.5859375
0.1640625
0.2109375

10115
0.8671875
0.7734375
0.890625
0.65625
0.6796875
0.7265625

10014
0.9375
1.1953125
1.40625
0.5859375
0.609375
0.609375

10085
1.6171875
1.4296875
1.4296875
1.265625
1.0546875
0.7265625

10047
7.3828125
1.265625
1.4296875
1.171875
0.609375
0.7265625

10051
1.359375
1.4765625
1.78125
0.9609375
0.8203125
0.609375

10056
1.6875
1.4296875
1.3125
1.2890625
0.7265625
1.125

10057
1.875
1.921875
1.8984375
1.8984375
0.9609375
1.078125

10039
1.2890625
1.03125
1.265625
1.2421875
0.796875
0.7734375

10067
0.75
0.75
0.5625
0.8203125
39.2578125
0.5625

10071
0.7265625
0.515625
0
0.515625
0.234375
0.1875

10104
1.545875
1.3359375
1.7109375
1.6171875
0.984375
0.9140625

10001
1.4296875
0.6796875
0.7265625
0.65625
0.46875
0.515625

10002
0.75
0.984375
1.1484375
1.0078125
0.5390625
0.4921875

10003
1.40625
1.078125
1.3359375
1.3125
0.984375
0.84375

10004
0.703125
0.515625
0.5390625
0.46875
0.75
0.5859375

10005
1.03125
0.984375
1.0546875
1.0078125
1.8515625
1.3125

10006
1.546875
0.9609375
1.1484375
1.21875
0.7734375
0.5625

10007
1.453125
1.171875
1.2890625
1.1953125
2.0859375
0.84375

10008
1.3828125
0.6796875
0.4453125
0.5390625
0.9375
0.609375

10009
1.5703125
1.1015625
1.0078125
0.8671875
0.7265625
0.75

10010
2.2734375
1.0546875
1.1015625
1.078125
0.8203125
1.5703125

10011
1.4296875
0.8671875
0.8671875
1.1484375
0.5390625
0.4921875

10012
0.9375
1.03125
1.0078125
0.9140625
1.5
1.2890625

10015
1.2890625
1.0546875
1.0546875
0.9140625
0.5625
0.5859375

10017
1.3359375
0.7734375
0.890625
0.8671875
0.375
0.2578125

CN + 75tPA
CN + 150tPA

CFF + TXA

Patient ID
CRT LY30
CN LY30
LY30
LY30
CFF LY30
LY30
CRT CL30
CN CL30

10027
0.032181149
0.036531072
0.610296293
0.877309947
0.001396878
−0.018850402
0.912123336
0.934834755

10036
0.620687849
0.570174492
0.883573059
0.90988339
0.723025145
−0.033342923
0.003840782
0.007555316

10013
0.122440453
0.17333015
0.764863695
0.920766765
0.18963098
−0.028770534
0.593161736
0.525195561

10099
0.700512063
0.676866667
0.862426372
0.803248588
0.741447884
−0.040334207
0.005529027
0.022545455

10107
0.206567617
0.301307892
0.721292673
0.869580028
0.486720653
−0.010193487
0.418545617
0.257952468

10093
0.157658839
0.205500806
0.659639012
0.875379913
0.443278128
−0.036288399
0.524144254
0.459086381

10044
0.795071377
0.8215557
0.874518786
0.844049815
0.814686964
−0.038434343
0.005782436
0.007073716

10068
0.413549604
0.333138705
0.684876616
0.863611367
0.646364594
−0.02922074
0.111365121
0.201390011

10030
0.049018013
0.048666115
0.5668166
0.87458624
0.190315235
−0.015613187
0.874441751
0.840135642

10077
0.104187707
0.107589411
0.630032517
0.814858822
0.300028085
0.030363322
0.632407545
0.656153196

10075
0.013590398
0.005073974
0.66195731
0.882000141
−0.01578034
−0.017857143
0.97717281
0.983767183

10090
0.273513001
0.251932409
0.654669364
0.873151169
0.479155882
−0.01954441
0.329092735
0.370097619

10059
0.403412504
0.205224691
0.634131061
0.750124763
0.628603256
−0.01975195
0.048403708
0.434256785

10061
0.01238212
0.016334176
0.341356822
0.715671685
0.025839479
0.022295783
0.976489723
0.968080862

10097
0.013837838
0.020287418
0.295816654
0.749214506
−0.006116442
−0.006813975
0.967567568
0.959096543

10025
0.020103147
0.020015858
0.301405728
0.60935634
0.018522173
0.001226813
0.951041928
0.950255954

10050
0.017763607
0.016338611
0.239333478
0.692515011
−0.002336723
−0.001073493
0.960532086
0.967506199

10060
0.033260983
−0.087673758
0.297550929
0.694521589
0.009783552
−0.057673629
0.937792388
1.141820024

10032
0.079844138
0.07552534
0.051217676
0.417378452
−0.010187088
−0.006750503
0.859234087
0.875775611

10106
0.037628265
0.009302761
0.455055955
0.935377457
0.003082386
−0.075740851
0.907649254
0.969820205

10063
0.036809352
0.00174796
0.006560459
0.550600117
−0.008719319
−0.015025572
0.932958199
0.987338719

10088
0.033335384
0.038860489
0.074793888
0.391418053
0.013625488
−0.012183384
0.926181102
0.90974212

10102
0.013800905
0.004507344
0.562845152
0.848988812
5.16E−04
0.005384027
0.972002262
0.984717269

10115
−9.07E−04
0.00166233
0.072674562
0.491382863
−0.014777091
−0.013430375
0.99515556
0.991030894

10014
0.036194424
0.0174196
0.016686346
0.239035744
−0.001005868
9.21E−04
0.930642339
0.961792623

10085
0.012515249
0.014965317
0.019434574
0.426500617
−0.00628196
0.00456849
0.971818958
0.965579303

10047
0.015036548
0.023598091
0.31609724
0.653241935
0.028920684
0.002780866
0.961126339
0.940027106

10051
0.051359495
0.036818989
0.129969698
0.588880654
0.003277692
0.00937838
0.900685741
0.916021848

10056
0.040883465
0.030727841
0.049351606
0.304203276
0.009619986
6.10E−04
0.918161152
0.934270222

10057
0.02123211
0.019522923
0.097372578
0.54744863
0.002834147
0.001678309
0.952088879
0.952893983

10039
0.030087314
0.021265554
0.065426612
0.356663192
−8.83E−04
0.001954369
0.937710034
0.951157111

10067
0.024026887
0.023099042
0.127341193
0.52226187
−0.089839901
−0.023327959
0.949104996
0.947476038

10071
0.029964163
0.015405989
1
0.823419372
0.074108123
0.010054454
0.913000424
0.946266189

10104
0.02263059
0.016736079
0.473321752
0.343410253
0.015296147
0.009525346
0.954550964
0.960018382

10001
0.044339839
0.035448853
0.125558464
0.574256955
0.003027092
0.014933231
0.905992303
0.920365169

10002
0.020561684
0.01556089
0.025736373
0.048507271
−0.026026803
−0.025764865
0.952032722
0.970827762

10003
0.023201246
0.02049543
0.285959784
0.639335257
3.64E−04
−0.006207827
0.950445173
0.953840814

10004
0.673048416
0.667148241
0.766353845
0.823688235
0.835254569
−0.004840428
0.004734528
0.005025126

10005
0.06026761
0.049426
0.075513843
0.383931977
−0.028563488
−0.02444461
0.87859116
0.892052809

10006
0.034280048
0.006880259
0.121344584
0.527154661
0.009525573
0.010931438
0.93723235
0.979279166

10007
0.014223939
0.015482503
0.175179896
0.483857435
−0.017598157
−0.017704437
0.970870113
0.968898951

10008
0.040747338
0.03000636
0.186974559
0.347914843
−0.022982836
−0.014046307
0.914505176
0.936712117

10009
0.026999381
0.014878642
0.07481
0.452688
0.003454802
4.71E−04
0.941683958
0.963065661

10010
0.034516958
0.035916
0.153788562
0.578757411
−0.007364583
7.22E−04
0.926964806
0.919979677

10011
0.023568783
0.021000454
0.034518465
0.19155214
−0.013607937
−0.027164812
0.945896587
0.949952674

10012
0.490499524
0.474602744
0.691469018
0.849708333
0.680998168
−0.020095
0.024932412
0.07380197

10015
0.021365601
0.017188087
0.094819042
0.270578957
−0.007755682
−0.005489257
0.950176317
0.959788241

10017
0.06030463
0.016644911
0.081614091
0.569954211
−0.001500615
−0.048368991
0.883525708
0.958975634

CFTX dV @ CFF max

Patient ID
CN + 75tPA CL30
CN + 150tPA CL30
CFF CL30
CFF + TXA CL30
(mm/min)

10027
0.003984785
0.006469875
0.98767461
1.029193698
0

10036
0.021917808
0.027303754
0.010680908
1.058688147
0.421875

10013
0.008221549
0.011242604
0.428816467
1.064108155
0.28125

10099
0.038554217
0.13559322
0.202978056
1.086500655
0.28125

10107
0.004039384
0.007588824
0.054554311
1.022652194
0.421875

10093
0.003660181
0.004752005
0.14637224
1.077275329
0.140625

10044
0.010549695
0.05904059
0.027444254
1.084297521
0.28125

10068
0.005203406
0.007383479
0.035827187
1.080028839
0.5625

10030
0.003636965
0.004418605
0.444286728
1.030020013
0.140625

10077
0.002448355
0.003066309
0.254694271
0.922886802
0.28125

10075
0.002786
0.004518498
1.033469691
1.035615354
0

10090
0.00980873
0.006525285
0.119930975
1.036753446
0.28125

10059
0.003016023
0.004130098
0.028277635
1.035095321
0.28125

10061
0.085127479
0.003677316
0.954743547
0.967379867
0.140625

10097
0.217642698
0.003891997
1.013474888
1.011105969
0

10025
0.20271581
0.00240855
0.963967056
0.998988196
0.140625

10050
0.334733488
0.003792368
1.0023465
1.002477291
0

10060
0.236238532
0.003279361
0.991847826
1.103661681
0.140625

10032
0.882370414
0.040428062
1.016809862
1.014486922
0

10106
0.063463515
0.010037641
0.928409091
1.132458234
0

10063
0.974855171
0.00234192
1.00916186
1.022743682
0

10088
0.789926763
0.08699734
0.984132981
1.036474164
0.140625

10102
0.002578566
0.005507745
1.008746356
0.993648553
0

10115
0.776780643
0.017445388
1.048890138
1.028829847
0.140625

10014
0.966520376
0.34714781
1.015088013
0.996856444
0

10085
0.957005804
0.040289118
1.019265073
0.994602375
0

10047
0.18950064
0.002949309
0.914398163
0.999047014
0.140625

10051
0.617421109
0.013085259
0.999068323
0.985399091
0

10056
0.842838196
0.175725987
0.978924863
1.000823497
0.140625

10057
0.667924988
0.003013699
0.995422643
1.001770956
0

10039
0.806439582
0.131063238
0.997866287
0.997877609
0

10067
0.636821074
0.004378284
1.329345531
1.064493013
−0.140625

10071
1
0.009777083
0.761251372
0.982497083
0.140625

10104
0.007070584
0.101463066
0.9706728
0.991066111
0.140625

10001
0.639192221
0.003555389
0.990047917
0.969953775
0

10002
0.939868003
0.883221477
1.070451843
1.076053757
0

10003
0.20441989
0.003322259
0.998214817
1.026160075
0.140625

10004
0.005485087
0.007529412
0.008355091
1.048026806
0.84375

10005
0.809435216
0.128636809
1.04513199
1.037488843
0.140625

10006
0.615618795
0.003166436
0.981231478
0.983039574
0.140625

10007
0.515861524
0.023453839
1.029501748
1.04021197
0.421875

10008
0.529515844
0.214223195
1.054860443
1.038157151
0

10009
0.794978088
0.02848
0.995246897
1.005616475
0.140625

10010
0.568701773
0.005447845
1.0225
1.008807339
0

10011
0.914828998
0.496624048
1.03428042
1.072496025
0

10012
0.003852637
0.004705882
0.007032967
1.0348
0.5625

10015
0.737313794
0.369005265
1.025568182
1.020979021
0

10017
0.768401438
0.002741604
1
1.199683043
0

CN dV @ CN + tPA75 max
CRT dA Integration to Acrit
CN dA Integration to Acrit

Patient ID
(mm/min)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10027
0.84375
4.167663574
85.9520874

10036
3.65625
3.351928711
35.29083252

10013
2.953125
0.851989746
30.48376465

10099
1.6875
0.16973877
7.577270508

10107
1.546875
0.385620117
19.28265381

10093
1.265625
0.853637695
56.30053711

10044
1.96875
0.402099609
18.49493408

10068
1.96875
55.67266846
57.52990723

10030
1.96875
0.866821289
124.614624

10077
0.84375
0.374084473
54.78771973

10075
0.84375
45.57073975
46.79187012

10090
1.40525
13.43243408
25.65362549

10059
1.546875
1.507873535
84.42773438

10061
0.140625
158.5063477
129.7397461

10097
0.28125
7.57232666
77.203125

10025
0.421875
24.0534668
150.218811

10050
0.28125
71.05297852
81.03790283

10060
0.84375
21.12670898
14.2399292

10032
0.5625
144.5267944
95.99468994

10106
0.5625
4.676879883
18.36639404

10063
0.140625
10.36724854
70.71185303

10088
0.140625
108.4498901
94.48846436

10102
0.984375
60.84887695
56.65649414

10115
0.28125
85.81365967
121.9993286

10014
0
13.54943848
111.3931274

10085
0.140625
18.49822998
173.6295776

10047
0.5625
685.0376587
147.9067383

10051
0.28125
22.11547852
186.1671753

10056
0.421875
44.68249512
126.6663208

10057
0.140625
50.58215332
200.618042

10039
0.28125
27.48944092
123.7412109

10067
0.421875
130.4022217
79.40478516

10071
1.125
3.468933105
37.39196777

10104
0.703125
40.84606934
138.3964233

10001
0.28125
18.53118896
75.84356689

10002
0.421875
33.03479004
134.4034424

10003
0.84375
88.00708008
157.7351074

10004
3.65625
0.405395508
75.09375

10005
0.28125
10.16784668
105.791748

10006
0.28125
22.12866211
92.40875244

10007
0.421875
25.69812012
125.6231689

10008
0.421875
79.16253662
75.42169189

10009
0.28125
126.6432495
176.0454712

10010
0.421875
342.4257202
90.99481201

10011
0.140625
120.1107788
102.0822144

10012
2.671875
1.974243164
84.82324219

10015
0.140625
16.7744751
146.3724976

10017
0.28125
21.30633545
94.42584229

CN + 75tPA dA Integration to Acrit
CN + 150tPA dA Integration to Acrit
CFF dA Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10027
101.4642334
45.04669189
10.11346436

10036
3.318969727
5.532165527
5.04107666

10013
26.18261719
28.65124512
2.231323242

10099
1.272216797
0.019775391
0.260375977

10107
41.2300415
48.57000732
0.393859863

10093
62.28094482
61.1685791
0.271911621

10044
7.592102051
0.552062988
0.052734375

10068
26.35565186
37.64080811
0.046142578

10030
154.8099976
178.7167969
18.28894043

10077
52.32073975
70.82391357
0.283447266

10075
69.48083496
39.81280518
29.9630127

10090
35.08813477
22.11383057
0.177978516

10059
79.0010376
80.16778564
2.480163574

10061
115.2773438
100.2183838
35.8560791

10097
74.16265869
68.04382324
30.8001709

10025
161.7544556
138.9138794
38.51916504

10050
91.74462891
71.90496826
11.390625

10060
119.973999
86.43164063
25.09991455

10032
120.9364014
131.7700195
20.671875

10106
10.99182129
13.90209961
0.385620117

10063
78.4588623
91.31121826
10.2288208

10088
91.61279297
64.3458252
49.21435547

10102
65.57684326
44.1897583
19.89239502

10115
85.35388184
97.12023926
19.7210083

10014
118.4084473
66.15362549
15.51049805

10085
155.5900024
159.0864258
35.84454346

10047
162.7630005
143.6055908
25.88598633

10051
231.9521484
107.1282349
40.11602783

10056
54.03625488
143.7094116
25.6206665

10057
164.661438
188.5501099
38.38238525

10039
88.77832031
101.6867065
10.98852539

10067
48.34094238
90.79046631
103.7993774

10071
0
39.15856934
4.624145508

10104
144.7278442
159.5033569
47.8861084

10001
60.63299561
53.13317871
13.2989502

10002
122.3388062
120.6018677
17.91815186

10003
175.6664429
143.7802734
55.2557373

10004
51.08477783
17.79125977
7.280639648

10005
104.5079956
97.47784424
35.14910889

10006
124.972229
106.2235107
32.91778564

10007
73.32220459
135.4202271
273.8776245

10008
47.03411865
63.8102417
73.72595215

10009
181.0288696
114.6494751
28.65618896

10010
116.6401978
93.13879395
35.91375732

10011
104.9727173
72.57733154
25.35040283

10012
82.31671143
86.3838501
19.26452637

10015
146.1582642
81.92449951
29.44885254

10017
128.0390625
101.446106
12.61669922

CFF + TXA dA

Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
ID
SBP
HR
OR?
ICU?
Death?
pRBC
FFP
PLT
CRYO
CN Crit Prod

10027
4.268188477
10027
150
Unk
Yes
Yes
Yes
61
12
2
6
9.774993896

10036
3.314025879
10036
0
0
Yes
Yes
No
32
8
3
4
5.292938232

10013
16.37072754
10013
96
100
Yes
Yes
Yes
29
16
5
0
4.790039063

10099
0.087341309
10099
80
120
Yes
Yes
Yes
27
12
4
6
0.937133789

10107
9.271362305
10107
0
130
Yes
Yes
Yes
24
13
2
2
3.150238037

10093
0.557006836
10093
70
140
Yes
Yes
No
23
12
2
2
8.470458984

10044
3.348632813
10044
140
93
Yes
Yes
No
21
12
1
1
1.876922607

10068
18.60534668
10068
160
70
No
Yes
Yes
14
12
2
1
6.747436523

10030
30.75897217
10030
180
40
Yes
Yes
Yes
12
8
2
1
17.94067383

10077
5.164672852
10077
0
110
Yes
Yes
No
11
4
1
0
7.565917969

10075
18.2477417
10075
100
100
Yes
Yes
No
9
4
2
0
5.518798828

10090
0.411987305
10090
Unk
Unk
Yes
Yes
No
9
4
2
2
4.843048096

10059
3.093200684
10059
180
150
Yes
Yes
Yes
8
6
1
2
10.78308105

10061
32.24707031
10061
108
112
Yes
Yes
No
7
6
2
0
15.24536133

10097
5.164672852
10097
104
130
Yes
Yes
No
7
4
1
0
8.840332031

10025
28.14532471
10025
204
102
Yes
Yes
Yes
6
4
1
1
17.07614136

10050
10.31945801
10050
107
89
Yes
Yes
No
6
4
1
0
10.52627563

10060
8.211730957
10060
70
112
Yes
Yes
No
6
3
0
0
1.726959229

10032
13.52142334
10032
0
0
Yes
Yes
No
5
6
1
0
13.8633728

10106
0.639404297
10106
0
122
Yes
Yes
No
5
3
0
0
1.931488037

10063
6.98236084
10063
80
100
Yes
Yes
No
4
2
1
0
11.31344604

10088
11.0725708
10088
102
110
Yes
Yes
No
4
4
1
0
10.51309204

10102
0.430114746
10102
122
90
Yes
Yes
Yes
4
5
2
2
8.326171875

10115
26.19085693
10115
102
130
Yes
Yes
<28 d
4
4
2
0
13.82821655

10014
20.10827637
10014
80
110
Yes
Yes
No
3
1
0
0
12.40603638

10085
24.3583374
10085
132
108
Yes
Yes
No
3
0
0
0
18.82608032

10047
27.24554443
10047
0
120
Yes
Yes
No
2
1
0
0
16.82885742

10051
22.52087402
10051
110
124
Yes
Yes
No
2
0
0
0
21.06985474

10056
60.17321777
10056
108
100
Yes
Yes
No
2
0
0
0
15.24069214

10057
52.54980469
10057
90
130
Yes
Yes
No
2
2
0
0
22.40185547

10039
21.26019287
10039
140
120
Yes
Yes
No
1
0
0
0
13.27734375

10067
16.0378418
10067
100
120
Yes
Yes
No
1
0
0
0
9.251953125

10071
2.059936523
10071
90
80
Yes
Yes
No
1
2
0
1
4.801757813

10104
30.43267822
10104
100
72
Yes
Yes
No
1
0
0
0
15.68161011

10001
13.25280762
10001
132
90
No
0
No
0
0
0
0
8.838592529

10002
20.62738037
10002
110
110
Yes
0
No
0
0
0
0
14.17346191

10003
47.34228516
10003
118
120
Yes
Yes
No
0
0
0
0
17.2668457

10004
5.617858887
10004
0
0
No
Yes
No
0
0
0
0
8.37890625

10005
15.49072266
10005
124
120
Yes
0
No
0
0
0
0
11.65869141

10006
21.35083008
10006
60
86
No
0
No
0
0
0
0
14.38778687

10007
30.1673584
10007
98
66
Yes
Yes
No
0
2
0
0
13.87939453

10008
37.30297852
10008
84
90
Yes
0
No
0
0
0
0
9.587310791

10009
37.08874512
10009
72
112
Yes
Yes
No
0
0
0
0
21.50198364

10010
45.75531006
10010
Walk-in
Walk-in
No
0
No
0
0
0
0
10.99594116

10011
20.23187256
10011
124
72
Yes
0
No
0
0
0
0
11.31747437

10012
20.21868896
10012
0
0
No
Yes
Yes
0
0
0
0
12.40722656

10015
28.83416748
10015
122
112
Yes
Yes
No
0
0
0
0
15.79147339

10017
9.226867676
10017
80
116
Yes
Yes
No
0
0
0
0
10.65591431

Patient ID

10027

10036

10013

10099

10107

10093

10044

10068

10030
Bad HF but good launch and MA

10077

10075

10090
SH but not MH and serious HF

10059

10061

10097

10025

10050

10060
SH but not MH

10032

10106
SH but not MH, also some HF

10063

10088

10102

10115

10014

10085

10047

10051

10056

10057

10039

10067

10071
Low launch, some HF

10104

10001

10002

10003

10004

10005

10006

10007

10008

10009

10010

10011

10012

10015

10017

CRT Amax
CN Amax
CN + 75tPA Amax
CN + 150tPA Amax
CFF Amax
CFF + TXA Amax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10019
67.765625
68.9609375
62
52.015625
27.8046875
25.765625

10020
68.9609375
66.2890625
62.890625
51.828125
23.8671875
23.328125

10022
59.890625
64.4140625
59.84375
61.0859375
22.296875
19.7421875

10023
63.1015625
68.4453125
55.6015625
35.3046875
32.234375
32.5390625

10024
62.46875
66.8984375
57.8515625
38.6796875
22.203125
20.46875

10026
51.6875
50.515625
52.7421875
26.5859375
13.90625
13.7890625

10028
64.0390625
69.59375
66.6171875
57.8984375
27.640625
26.84375

10029
65.6796875
65.140625
47.84375
29.421875
25.1328125
26.375

10031
61.8359375
61.1796875
49.0625
33.6640625
23.8203125
24.0078125

10033
62.0234375
66.59375
57.9453125
42.1484375
24.5234375
24.2421875

10034
60.640625
57.6875
43.0625
31.1796875
20.609375
17.8203125

10035
56.65625
60.5
52.6015625
47.0234375
20.046875
19.671875

10037
66.40625
70.53125
66.875
62.46875
25.25
24.6640625

10038
60.8046875
58.625
51.7578125
51.0546875
23.0234375
24.8046875

10040
65.5859375
61.2265625
49.296875
46.6484375
25.8125
23.65625

10041
59.140625
63.546875
55.203125
35.3515625
21.1953125
21.0546875

10042
62.75
63.78125
56.5859375
44.28125
22.9296875
21.4765625

10043
62.8671875
64.015625
54.6640625
36.640625
19.765625
19.6953125

10045
62.65625
63.171875
48.171875
25.6484375
27.9921875
23.703125

10046
49.6953125
55.7890625
51.40625
31.578125
19.15625
17.65625

10048
74.703125
73.8828125
65.890625
56.1171875
31.6953125
34.484375

10049
58.7421875
62.609375
55.4140625
49.859375
19.6484375
17.984375

10052
71.796875
70.2734375
67.0390625
35.234375
31.34375
29.3984375

10053
65.5625
66.359375
62.0703125
57.6171875
24.2421875
23.5859375

10054
59.4453125
59.9375
50.4921875
41.65625
21.4765625
21.1484375

10055
66.40625
66.21875
48.2890625
50.7734375
28.671875
26.84375

10058
57.8984375
58.7890625
50.84375
32.609375
21.6171875
20.84375

10062
62.5859375
64.7421875
63.40625
58.9765625
25.4375
24.4765625

10064
72.78125
71.8671875
72.6640625
66.1953125
36.40625
34.9296875

10065
57.0546875
58.25
49.203125
35.3984375
21.2421875
22.15625

10069
65.5625
69.9921875
70.8125
69.9453125
28.8125
28.4375

10070
48.546875
58.34375
52.9296875
46.1328125
17.2578125
15.6875

10072
67.9765625
64.25
63.8515625
54.921875
21.078125
22.203125

10073
72.078125
73.8828125
71.984375
28.5078125
31.9296875
93.78125

10074
64.7890625
67.7890625
62.328125
51.265625
20.140625
20.515625

10076
63.8984375
66.125
59.84375
49.765625
23.09375
23.375

10078
68.2578125
65.4921875
61.2734375
52.3203125
27.734375
26.28125

10079
70.1328125
71.6328125
67.8828125
41.4921875
40.0390625
31.0625

10080
56.0234375
55.859375
56.75
36.8515625
18.2421875
16.4609375

10081
69.3359375
68.46875
67.296875
62.984375
27.4765625
25.4375

10082
53.703125
51.40625
54.9921875
53.3515625
20.1171875
18.8515625

10083
58.6015625
62.328125
61.6484375
55.15625
25.15625
22.390625

10084
63.640625
65.2578125
63.4765625
57.4765625
27.265625
26.1875

10086
65.65625
64.6953125
62.75
46.3671875
26.234375
24.5703125

10087
70.34375
66.59375
66.6875
59.046875
31.625
33.9453125

10089
63.40625
72.1953125
68.2578125
60.0078125
27.171875
28.4609375

10092
67.90625
69.7578125
68.9140625
61.765625
21.40625
21.2890625

10094
64.671875
65.0703125
63.03125
58.7421875
26.1640625
24.8046875

CRT Acrit
CN Arit
CN + 75tPA Acrit
CN + 150tPA Acrit
CFF Acrit
CFF + TXA Acrit

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10019
2.36328125
16.12109375
13.66015625
9.0078125
1.484375
4.4140625

10020
2.2109375
16.37890625
14.1171875
13.44921875
4.80078125
5.31640625

10022
1.1796875
11.046875
10.49609375
12.39453125
1.3203125
1.1796875

10023
11.01171875
16.51953125
13.0625
13.0625
4.4140625
6.58203125

10024
1.1796875
6.78125
18.69921875
10.484375
3.921875
3.265625

10026
11.41015625
10.56640625
8.7734375
7.89453125
0.32421875
1.671875

10028
1.484375
14.65625
15.8046875
14
3.4765625
3.67578125

10029
7.09765625
16.47265625
10.625
13.8125
4.14453125
4.21484375

10031
14
12.46484375
12.65234375
11.84375
2.10546875
3.875

10033
1.75390625
13.87109375
15.93359375
13.21484375
5.84375
5.09375

10034
14.33984375
12.69921875
13.84765625
9.16015625
0.8515625
2.609375

10035
1.89453125
10.390625
8.46875
7.84765625
4.35546875
2.85546875

10037
1.859375
14.46875
15.5234375
13.015625
4.19140625
4.58984375

10038
4.28515625
12.265625
16.4375
14.4921875
3.79296875
5.69140625

10040
6.55859375
11.59765625
10.98828125
17.03515625
6.37109375
5.75

10041
1.14453125
14.046875
8.1640625
9.98046875
3.25390625
3.21875

10042
2.1875
14.234375
14.69140625
10.3203125
4.16796875
3.3125

10043
4.77734375
13.30859375
15.3359375
12.44140625
5.31640525
4.56640625

10045
12.1015625
13.2734375
12.0546875
9.40625
7.109375
5.7265625

10046
0.8984375
7.77734375
6.67578125
7.671875
2.3046875
1.90625

10048
7.84765625
14.984375
21.37109375
14.97265625
8.57421875
8.64453125

10049
14.66796875
11.4453125
11.328125
11.71484375
3.83984375
2.9140625

10052
7.578125
15.1953125
18.3359375
11.69140625
6.21875
4.49609375

10053
1.6953125
15.39453125
13.05078125
11.1171875
4.1328125
4.82421875

10054
12.96875
12.11328125
12.0078125
14.3515625
3.9453125
3.6875

10055
6.16015625
13.28515625
9.04296875
12.76953125
7.54296875
6.734375

10058
2.09375
11.69140625
9.5234375
11.1171875
4.42578125
3.04296875

10062
1.28515625
14.4921875
12.30078125
12.0546875
4.109375
4.90625

10064
5.73828125
12.9921875
14.45703125
14.80859375
5.73828125
5.421875

10065
4.15625
12.453125
6.51171875
9.1015625
4.12109375
5.48046875

10069
2.7265625
15.76953125
14.50390625
14.8203125
5.90234375
6.18359375

10070
1.56640625
9.8984375
8.99609375
10.77734375
2.45703125
15.96875

10072
13.26171875
15.55859375
15.125
14.87890625
5.140625
3.60546875

10073
7.0859375
15.37109375
16.859375
20.57421875
7.5078125
46.75390625

10074
1.58984375
11.1875
8.94921875
9.0078125
3.13671875
2.90234375

10076
2.66796875
14.3515625
17.6328125
13.75390625
4.49609375
4.484375

10078
7.765625
19.21484375
14.7734375
15.2421875
6.078125
6.40625

10079
2.48046875
10.98828125
12.11328125
14.2109375
11.046875
5.22265625

10080
11.69140625
12.58203125
10.58984375
12.32421875
4.15625
19.30859375

10081
17.10546875
15.95703125
15.828125
18.55859375
7.4140625
5.24609375

10082
2.1171875
15.2890625
14.85546875
13.8359375
4.87109375
3.875

10083
2.43359375
10.89453125
10.6953125
10.33203125
4.15625
3.46484375

10084
6.23046875
14.65625
12.546875
12.20703125
4.8125
4.70703125

10086
17.796875
17.703125
17.234375
14.2578125
5.796875
4.28515625

10087
14.03515625
19.0625
26.41015625
19.47265625
7.23828125
7.40234375

10089
3.2421875
12.5703125
11.64453125
10.6484375
5.03515625
8.2578125

10092
17.76171875
16.859375
16.70703125
14.65625
3.76953125
3.72265625

10094
2.48046875
12.828125
14.29296875
15.53515625
6.25390625
6.21875

CRT dAmax
CN dAmax
CN + 75tPA dAmax
CN + 150tPA dAmax
CFF dAmax
CFF + TXA dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10019
1.6640625
1.1953125
1.1953125
1.125
1.5
0.703125

10020
1.359375
0.8671875
0.890625
0.8203125
0.5390625
0.5390625

10022
0.984375
0.9375
0.8203125
1.0546875
0.9375
0.796875

10023
1.5234375
1.1953125
0.9375
0.46875
1.03125
1.1953125

10024
0.9375
1.171875
0.9140625
1.078125
0.515625
0.421875

10026
0.7265625
0.8203125
0.9375
0.8203125
0.1640625
0.140625

10028
1.40625
1.40625
1.40625
1.40625
0.84375
0.8671875

10029
1.2421875
0.7265625
0.609375
0.421875
0.8671875
0.8671875

10031
1.21875
1.1015625
1.0078125
0.890625
1.1953125
0.46875

10033
1.1015625
0.8671875
0.8671875
0.8203125
0.796875
0.75

10034
0.8203125
0.8203125
0.6328125
0.6796875
0.5625
0.375

10035
1.3828125
1.03125
0.9375
1.0546875
0.8203125
0.6328125

10037
1.546875
1.5
1.5
1.5
0.8671875
0.7734375

10038
1.1484375
0.65625
0.515625
0.609375
0.9140625
1.0546875

10040
1.1484375
0.6796875
0.4453125
0.6796875
0.9609375
0.890625

10041
0.8671875
0.9375
1.03125
0.8203125
0.6328125
0.5625

10042
1.125
1.03125
1.1953125
1.265625
0.8671875
0.703125

10043
0.9609375
1.0546875
0.984375
1.0078125
0.5859375
0.6796875

10045
0.984375
1.03125
0.75
0.703125
1.171875
0.75

10046
0.796875
1.1015625
1.1484375
1.125
0.421875
0.328125

10048
1.9453125
1.640625
1.1015625
1.2421875
0.9609375
1.1484375

10049
0.8671875
0.9375
0.9375
0.8671875
0.5390625
0.375

10052
1.359375
1.21875
1.3125
0.7265625
0.796875
0.5859375

10053
1.6875
1.1015625
1.1953125
1.125
0.65625
0.6796875

10054
0.890625
0.7734375
0.703125
0.75
0.421875
0.421875

10055
1.3359375
1.0546875
1.0546875
1.1953125
1.1484375
0.9375

10058
1.734375
1.0546875
1.125
1.03125
0.6796875
0.4921875

10062
1.1953125
0.796875
0.8671875
0.890625
0.703125
0.65625

10064
1.5234375
1.359375
1.5234375
1.4765625
1.1015625
1.078125

10065
1.03125
0.75
0.9609375
1.03125
0.9140625
0.8203125

10069
2.295875
1.4296875
1.6171875
1.453125
0.9140625
0.8671875

10070
0.8203125
0.984375
0.9609375
1.0078125
0.4453125
1.078125

10072
1.3359375
0.9140625
1.171875
1.1015625
0.46875
0.4921875

10073
4.03125
1.8984375
2.203125
5.0859375
1.171875
3.1640625

10074
1.1015625
1.21875
1.5703125
1.3125
0.5859375
0.5390625

10076
2.0390625
1.171875
1.078125
0.9609375
0.6796875
0.609375

10078
1.875
1.1484375
1.171875
1.078125
1.171875
0.984375

10079
2.2265625
1.9921875
2.1796875
2.296875
2.953125
1.2421875

10080
0.8671875
0.4921875
0.8203125
0.7734375
0.515625
3.1171875

10081
1.4765625
1.0546875
1.171875
1.0078125
0.9375
0.5859375

10082
1.734375
0.515625
0.6796875
0.5625
0.4453125
0.46875

10083
1.7109375
1.0546875
1.40625
1.5703125
1.03125
0.6328125

10084
1.8046875
1.265625
1.3125
1.3828125
0.9375
0.9140625

10086
0.84375
0.703125
0.75
0.609375
0.75
0.5859375

10087
1.2890625
0.796875
0.9609375
0.6328125
0.5390625
0.8671875

10089
1.96875
2.15625
2.2265625
1.453125
1.1015625
2.15625

10092
0.9609375
0.9375
1.0546875
1.125
0.5390625
0.6328125

10094
2.2734375
1.125
1.0546875
1.1015625
1.0078125
0.890625

CN + 75tPA
CN + 150tPA

CFF + TXA

Patient ID
CRT LY30
CN LY30
LY30
LY30
CFF LY30
LY30
CRT CL30
CN CL30

10019
0.018560257
0.022788509
0.100859305
0.454886769
0.003487637
−0.009435011
0.957804934
0.950039651

10020
0.030007206
0.014039481
0.060452899
0.432118003
−0.003161484
−0.006205347
0.947320721
0.965350619

10022
0.015688864
0.01108298
0.011277198
0.026278403
0.04736335
0.043820077
0.962822854
0.970527592

10023
0.050798564
0.02016465
0.106925905
0.536037656
0.001784416
0.006433573
0.900829516
0.94966328

10024
0.051351544
0.03619448
0.432249981
0.633892143
0.02721235
0.135655746
0.900575288
0.918019386

10026
0.0408322
0.045881663
0.128821656
0.681686502
−0.007343165
−0.002573182
0.912031439
0.903495206

10028
0.036332229
0.01844581
0.070189301
0.48095455
−0.011132702
−0.006824796
0.936318165
0.970026942

10029
0.04213007
0.013138143
0.265292973
0.589190565
0.0284828
−0.018540186
0.911145474
0.962221156

10031
0.075543799
0.097434874
0.609129512
0.6387822
0.367293922
−0.005472394
0.79949463
0.741412336

10033
0.026377517
0.018340861
0.095054717
0.423588199
−4.86E−04
−0.002458642
0.949741781
0.956710465

10034
0.033425663
0.02512734
0.18634948
0.60229057
0.013688821
0.013426129
0.931203298
0.947183099

10035
0.020279463
0.02175914
0.0364523
0.300278285
−0.013139777
−0.010031109
0.953667954
0.953899793

10037
0.030046405
0.021488548
0.062978323
0.313275214
0.001045534
0.001356773
0.942470588
0.956468764

10038
0.026372114
−0.001829025
0.002257233
0.024505653
−0.004964088
−0.005459318
0.934087113
0.988006397

10040
0.04965042
0.028593531
0.079753038
0.362801457
−0.003030418
−0.015363551
0.906372841
0.931478882

10041
0.041559335
0.021645254
0.072059274
0.468926949
0.01875384
0.003831169
0.914002642
0.943570199

10042
0.028059636
0.027165333
0.159310139
0.555088509
6.02E−04
0.007616406
0.939492032
0.943042626

10043
0.019282548
0.021101822
0.340209296
0.615954158
−0.004230896
−0.006153312
0.954517211
0.947644618

10045
0.010444722
0.012927694
0.233396854
0.717038532
−0.026521072
−0.031434025
0.975311721
0.969577047

10046
0.020347299
0.019610932
0.229340172
0.645899307
−0.015154296
−0.010567847
0.953309228
0.952947766

10048
0.020143973
0.015210808
0.060154171
0.495028192
0.013921412
0.010570533
0.950428781
0.969546368

10049
0.040608237
0.031604588
0.075264933
0.473617858
7.89E−04
0.004389299
0.911823381
0.92887447

10052
0.017503627
0.013801031
0.157126695
0.32081578
−0.006094217
−0.007797413
0.956909684
0.972984992

10053
0.011311864
0.015675281
0.046222991
0.305119209
−0.011028306
−0.012549685
0.972473785
0.96362138

10054
0.054953929
0.027473823
0.167679483
0.604487059
0.017146639
0.007753048
0.889998686
0.934306569

10055
0.015969118
0.017118432
0.101571797
0.302263169
−0.002832652
−0.012365396
0.960823529
0.956111373

10058
0.029763752
0.026953488
0.492045474
0.728459911
0.010215637
0.009807596
0.934421805
0.93461794

10062
0.021739726
0.016778287
0.018351097
0.420841429
5.95E−04
−0.006456804
0.955436275
0.960178593

10064
0.026595224
0.023099733
0.078911616
0.501083179
5.00E−04
0.003245918
0.945577501
0.952060007

10065
0.018600233
0.025373115
0.662967521
0.860495292
−0.003749847
−0.016334626
0.956045461
0.947290773

10069
0.013138008
0.011164596
0.068198674
0.405900722
−0.021435512
−0.05345696
0.968898951
0.978569037

10070
0.022669018
0.016251562
0.166666052
0.620378916
0.027281701
0.026450448
0.955101384
0.963042314

10072
0.026998812
0.019600661
0.100680595
0.428920697
−0.005763529
0.001426519
0.937938168
0.952942607

10073
0.032281957
0.033183973
0.030185044
0.277177537
0.0096862
0.963302857
0.928463039
0.927038173

10074
0.024875899
0.031321629
0.480037116
0.733005689
0.043781786
0.007443196
0.937417099
0.921170912

10076
0.045710899
0.028091361
0.164391319
0.455341226
0.015017479
0.009141971
0.910869299
0.940808129

10078
0.03587902
0.036731083
0.051553756
0.569544199
0.005193271
0.007651688
0.927206135
0.920553501

10079
0.012896383
0.004602465
0.445629052
0.813086048
−0.057418699
−0.009947183
0.970925699
0.996073727

10080
0.028764003
0.019558275
0.224187202
0.704488199
0.030031525
−0.024219533
0.934737136
0.95048951

10081
0.03960892
0.020360281
0.024098689
0.183163642
0.006851246
0.018016738
0.918197183
0.949680511

10082
0.03400434
0.026273852
0.028358471
0.054769895
−0.160043689
−0.015227126
0.924934536
0.945744681

10083
0.02385182
0.019988301
0.277498451
0.702136449
0.020317892
0.010942952
0.945607252
0.953371772

10084
0.009423337
0.021685821
0.224975897
0.606549884
0.018206383
0.00716612
0.970905966
0.946845445

10086
0.036625251
0.023212273
0.025188655
0.276866049
−0.109540649
−0.524623741
0.932175155
0.947470112

10087
0.024173361
0.017043544
0.044756847
0.265357348
−0.111567441
−0.048439778
0.95302088
0.964453308

10089
0.020497577
0.025572178
0.048802507
0.569068155
−0.004630295
0.004302772
0.950468211
0.941240126

10092
0.02308093
0.009447213
0.061420505
0.423262923
−1.74E−04
−0.029998471
0.95478601
0.973457274

10094
0.029986443
0.02516742
0.093868782
0.476873587
−0.017023738
−0.002700787
0.938390916
0.947052467

CFTX dV @ CFF max

Patient ID
CN + 75tPA CL30
CN + 150tPA CL30
CFF CL30
CFF + TXA CL30
(mm/min)

10019
0.691532258
0.013667768
0.983984265
1.018192844
0.28125

10020
0.849068323
0.102351522
1.00589198
1.015070328
0

10022
0.967101828
0.933623225
0.90119131
0.909774436
0.28125

10023
0.72179289
0.028103563
0.993456132
0.987755102
0

10024
0.019986496
0.003837609
0.933497537
0.966793893
0.28125

10026
0.658717227
0.004701734
1.001685393
0.996600567
0

10028
0.773777413
0.004587775
1.014414924
1.010477299
0

10029
0.398922273
0.00424854
0.917003419
1.042654028
0.140625

10031
0.002547771
0.003713159
0.128238767
1.015619915
0.421875

10033
0.732236753
0.125857275
1
1.012568482
0.140625

10034
0.460087083
0.007767477
0.977255497
0.978956598
0.140625

10035
0.904203178
0.145705267
1.018706157
1.016679905
0.140625

10037
0.834579439
0.129564782
0.993502475
0.994298385
0

10038
0.985962264
0.952716144
1.007125891
1.011338583
0.140625

10040
0.806022187
0.176519845
1.006355932
1.052509908
0

10041
0.799179168
0.114254144
0.950239587
0.99109462
0.140625

10042
0.521192876
0.002822865
1
0.99454347
0

10043
0.184936401
0.004690832
1.008300395
1.020230067
−0.140625

10045
0.378203049
0.004873591
1.060284678
1.070204351
−0.140625

10046
0.37218845
0.003958435
1.024469821
1.015929204
0

10048
0.82712829
0.027286649
0.96672418
0.980969642
0.140625

10049
0.805864937
0.016139141
0.992842942
0.990877498
0

10052
0.563337606
0.26097561
1.011964108
1.014350252
0

10053
0.874260541
0.198237288
1.016435707
1.02285525
0

10054
0.543710351
0.00300075
0.973808658
0.992242335
0.140625

10055
0.729655396
0.224957686
1.004087193
1.023573923
0

10058
0.015826675
0.003833253
0.976147452
0.982008996
0.140625

10062
0.957121735
0.065704067
1.011977887
1.016278327
0

10064
0.756800344
0.004366812
1.018669528
0.999329009
−6.00E−15

10065
0.002540489
0.003531229
1.005516734
1.029619182
0

10069
0.781553398
0.068803753
1.087039046
1.212637363
−0.140625

10070
0.493874539
0.003725656
0.95382526
0.947709163
0.140625

10072
0.690566499
0.006970128
1.015567087
1.001055595
−0.140625

10073
0.920555676
0.259249109
0.983117201
0.001582806
2.109375

10074
0.017798947
0.002438281
0.867339022
0.99428789
0.140625

10076
0.53002611
0.096232339
0.967523681
0.987967914
0.28125

10078
0.851969909
0.002389129
0.998309859
0.991973841
0.140625

10079
0.007710899
0.035209942
1.164487805
1.018108652
0.140625

10080
0.304102423
0.003391986
0.944753747
1.316089226
0.140625

10081
0.948804272
0.434383528
0.981234006
0.962223587
0.140625

10082
0.941184827
0.858544443
1.481165049
1.103191048
0

10083
0.251805855
0.002266289
0.961801242
0.988485694
0.140625

10084
0.3472
0.0021748
0.976790831
0.99552506
0.140625

10086
0.945094622
0.358550969
1.363609291
2.398410175
0.28125

10087
0.880506092
0.307356444
1.343873518
1.18296893
−0.140625

10089
0.835213803
0.002083062
1.024151811
0.996706012
0.140625

10092
0.8234894
0.033898305
1.048175182
1.153027523
0.140625

10094
0.704015865
0.025269318
1.058226336
1.009448819
0

CN dV @ CN + tPA75 max
CRT dA Integration to Acrit
CN dA Integration to Acrit

Patient ID
(mm/min)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10019
0.5625
31.7411499
176.0718384

10020
0.140625
24.37976074
108.4432983

10022
0.140625
8.127685547
89.33532715

10023
0.140625
146.5043335
175.1193237

10024
0.421875
7.781616211
66.48486328

10026
0.421875
83.27911377
72.15545654

10028
0.140625
14.05371094
177.543457

10029
0.84375
87.20123291
108.4235229

10031
0.984375
161.4298096
104.6365356

10033
0.421875
15.75604248
107.480896

10034
0.84375
88.0713501
91.47601318

10035
0.421875
20.97674561
93.51123047

10037
0.28125
20.60925293
194.5535889

10038
0
46.12445068
64.14477539

10040
0.28125
73.39471436
60.17816162

10041
0.421875
6.969177246
111.1772461

10042
0.421875
22.359375
139.6043701

10043
0.5625
31.41156006
120.5161743

10045
0.5625
110.9465332
121.7636719

10046
0.28125
4.541748047
76.05780029

10048
0.28125
105.1243286
179.8571777

10049
0.28125
130.3511353
96.63244629

10052
0.28125
80.39025879
158.8392334

10053
0.140625
19.06677246
161.8994751

10054
0.421875
106.6256104
81.1038208

10055
0.28125
76.30169678
120.0481567

10058
0.703125
27.76794434
110.1373901

10062
0.140625
10.21893311
93.27392578

10064
0.140625
78.70770264
116.4210205

10065
1.265625
41.66015625
77.69421387

10069
0.140625
47.99816895
197.9401245

10070
0.421875
11.39886475
91.3392334

10072
0.28125
169.7272339
128.9833374

10073
0
266.918335
257.6453247

10074
0.703125
13.6137085
120.9594727

10076
0.5625
42.14959717
142.8343506

10078
0.28125
104.5129395
177.0441284

10079
0.5625
40.72576904
186.0320435

10080
0.984375
80.52703857
36.67181396

10081
0.140625
273.0470581
143.079895

10082
0.140625
28.32495117
68.89086914

10083
0.28125
34.64154053
100.2694702

10084
0.140625
100.7177124
178.5157471

10086
0.140625
128.4246826
100.1524658

10087
0.28125
138.6172485
140.5206299

10089
0.140625
53.89782715
196.9431152

10092
0.28125
155.1560669
153.1142578

10094
0.703125
41.04217529
112.9405518

CN + 75tPA dA Integration to Acrit
CN + 150tPA dA Integration to Acrit
CFF dA Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10019
131.9265747
77.90844727
14.46240234

10020
107.7000732
88.54925537
21.88970947

10022
71.53582764
119.2175903
8.803344727

10023
96.00292969
48.77600098
45.24279785

10024
171.0027466
99.48999023
17.62646484

10026
69.8104248
50.5178833
0.278503418

10028
192.3255615
163.6281738
24.4588623

10029
49.97900391
52.5201416
30.09979248

10031
95.62884521
86.88647461
1.105773926

10033
101.4098511
85.96856689
42.42150879

10034
77.46844482
49.8883667
3.371704102

10035
68.41296387
68.36846924
34.21307373

10037
209.1115723
169.8145752
34.14385986

10038
73.65673828
75.53210449
30.17559814

10040
37.54193115
100.8495483
53.66217041

10041
30.91552734
69.57476807
18.02032471

10042
149.2036743
113.6920166
24.84283447

10043
126.173584
105.0518188
29.10772705

10045
73.59741211
55.30517578
70.72998047

10046
48.24041748
76.40222168
7.864013672

10048
184.911438
147.2590942
56.56915283

10049
91.41833496
94.50164795
16.1416626

10052
190.2095947
46.33209229
34.28393555

10053
101.8580933
103.1022949
20.61584473

10054
66.59692383
82.92810059
15.07543945

10055
55.00360107
129.8139038
59.88153076

10058
89.20019531
79.67834473
26.85992432

10062
81.41363525
100.6468506
23.73046875

10064
205.6195679
207.8245239
56.35821533

10065
48.6260376
74.17749023
31.25335693

10069
188.4710083
182.1873779
48.08880615

10070
58.20062256
104.883728
8.679748535

10072
158.1075439
152.0348511
17.0859375

10073
311.8677979
98.69732666
62.96813965

10074
96.13311768
108.487793
11.56365967

10076
103.7120361
111.0997925
26.94232178

10078
124.2784424
139.541748
59.2701416

10079
230.6552124
201.6463623
238.847168

10080
79.13616943
87.91644287
15.51708984

10081
147.1552734
149.0718384
61.43225098

10082
87.04962158
64.06237793
18.13897705

10083
137.142334
149.5794067
38.19287109

10084
151.3707275
155.8811646
42.3951416

10086
110.9432373
68.44262695
35.31884766

10087
191.46698
111.8084106
32.47283936

10089
151.2372437
114.6115723
50.00042725

10092
148.8806763
155.2236328
14.43109131

10094
119.8833618
155.0736694
54.3147583

CFF + TXA dA

Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
ID
SBP
HR
OR?
ICU?
Death?
pRBC
FFP
PLT
CRYO
CN Crit Prod

10019
28.41064453
10019
86
90
Yes
Yes
No
0
0
0
0
19.26974487

10020
22.59503174
10020
136
100
Yes
0
No
0
0
0
0
14.20358276

10022
6.862060547
10022
138
88
No
Yes
No
0
0
0
0
10.35644531

10023
76.33795166
10023
106
120
Yes
0
No
0
0
0
0
19.7460022

10024
8.737426758
10024
150
108
Yes
Yes
No
0
0
0
0
7.946777344

10026
1.496337891
10026
116
100
Yes
Yes
No
0
0
1
0
8.667755127

10028
26.37213135
10028
102
100
No
Yes
No
0
0
0
0
20.61035156

10029
31.25994873
10029
62
120
Yes
Yes
No
0
0
0
0
11.96841431

10031
15.78076172
10031
Uto
Uto
Yes
Yes
No
0
0
0
0
13.73080444

10033
34.27734375
10033
110
94
Yes
Yes
No
0
0
0
0
12.02883911

10034
7.218017578
10034
140
100
Yes
Yes
No
0
0
0
0
10.41732788

10035
14.93206787
10035
80
70
Yes
Yes
No
0
0
0
0
10.71533203

10037
33.68243408
10037
180
120
No
Yes
No
0
0
0
0
21.703125

10038
40.28082275
10038
128
120
Yes
Yes
No
0
0
0
0
8.049316406

10040
27.57348633
10040
162
108
No
0
No
0
0
0
0
7.882781982

10041
15.65222168
10041
88
70
Yes
Yes
No
0
2
1
0
13.16894531

10042
19.11621094
10042
100
90
Yes
Yes
No
0
0
0
0
14.67919922

10043
26.66546631
10043
90
60
Yes
Yes
No
0
0
0
0
14.03640747

10045
37.99841309
10045
100
58
No
Yes
Yes
0
0
0
0
13.68823242

10046
5.115234375
10046
130
90
No
0
No
0
0
0
0
8.567230225

10048
80.21722412
10048
88
112
No
0
No
0
0
0
0
24.58374023

10049
9.149414062
10049
Walk-in
Walk-in
No
0
No
0
0
0
0
10.72998047

10052
21.70184326
10052
100
100
Yes
Yes
No
0
0
0
0
18.51928711

10053
28.09588623
10053
116
110
Yes
Yes
No
0
0
0
0
16.95803833

10054
13.2989502
10054
108
124
Yes
Yes
No
0
0
0
0
9.368865967

10055
55.71386719
10055
136
78
No
Yes
No
0
0
0
0
14.01158823

10058
11.59661865
10058
118
110
Yes
Yes
No
0
0
0
0
12.33078003

10062
25.08178711
10062
86
60
No
0
No
0
0
0
0
11.54846191

10064
51.12597656
10064
118
72
No
0
No
0
0
0
0
17.66125488

10065
38.93609619
10065
140
120
No
Yes
No
0
0
0
0
9.33984375

10069
39.92816162
10069
90
140
Yes
Yes
No
0
0
0
0
22.54550171

10070
20.0291748
10070
160
92
Yes
0
No
0
0
0
0
9.743774414

10072
14.16412354
10072
Unk
Unk
No
0
No
0
0
0
0
14.2215271

10073
963.953064
10073
156
114
Yes
Yes
No
0
0
0
0
29.18106079

10074
13.36651611
10074
81
100
Yes
Yes
No
0
0
0
0
13.63476563

10076
20.18408203
10076
170
60
Yes
Yes
No
0
0
1
0
16.8182373

10078
55.34472656
10078
96
60
Yes
Yes
No
0
0
0
0
22.06704712

10079
49.64117432
10079
82
112
No
Yes
No
0
0
0
0
21.89071655

10080
96.45941162
10080
98
112
No
0
No
0
0
0
0
6.192718506

10081
24.95159912
10081
Walk-in
Walk-in
Yes
Yes
No
0
0
0
0
16.8296814

10082
11.51916504
10082
138
120
No
0
No
0
0
0
0
7.883422852

10083
19.47052002
10083
142
70
Yes
Yes
No
0
0
0
0
11.49032593

10084
29.05499268
10084
170
104
No
Yes
No
0
0
0
0
18.54931641

10086
18.47186279
10086
100
120
Yes
0
No
0
0
0
0
12.44750977

10087
53.8895874
10087
162
120
No
0
No
0
0
0
0
15.19042969

10089
125.1551514
10089
120
80
Yes
Yes
No
0
0
0
0
27.10473633

10092
20.99981689
10092
210
128
No
0
No
0
0
0
0
15.80556406

10094
50.6184082
10094
128
100
Yes
Yes
No
0
0
0
0
14.43154063

Patient ID

10019

10020

10022

10023

10024

10026

10028

10029

10031

10033

10034

10035

10037

10038

10040

10041

10042

10043

10045

10046

10048

10049

10052

10053

10054

10055

10058

10062

10064

10065

10069

10070

10072

10073

10074

10076

10078

10079

10080

10081

10082

10083

10084

10086

10087

10089

10092

10094

CRT Amax
CN Amax
CN + 75tPA Amax
CN + 150tPA Amax
CFF Amax
CFF + TXA Amax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10096
63.640625
65.1875
64.7421875
65.1875
24.6171875
24.8984375

10098
59.703125
66.171875
62.5625
61.625
19.296875
19.953125

10100
66.734375
71.65625
67.6015625
54.125
26.0703125
26.65625

10101
63.0546875
66.6640625
64.1328125
55.25
24.3359375
24.3359375

10103
66.4296875
68.46875
63.7109375
46.484375
28.390625
26.65625

10105
56.7734375
60.4296875
62.140625
52.203125
26.5625
24.5

10108
52.2265625
65.375
58.765625
59
20.2578125
18.734375

10109
62.8671875
66.3828125
63.546875
58.8359375
24.359375
24.0546875

10110
65.84375
64.15625
66.78125
65.5625
22.7890625
21.9921875

10111
67.6015625
73.5078125
71.1875
68.6796875
26.6328125
26.65625

10112
82.1328125
62.5625
60.03125
54.4765625
29.2578125
0.125

10113
50.3046875
48.125
28.6015625
23.5625
15.9921875
14.65625

CRT Acrit
CN Arit
CN + 75tPA Acrit
CN + 150tPA Acrit
CFF Acrit
CFF + TXA Acrit

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10096
18.40625
16.15625
13.9765625
13.75390625
3.67578125
4.71875

10098
1.84765625
6.41796875
7.09765625
8.19921875
1.56640625
2.19921875

10100
2.29296875
13.15625
16.82421875
16.765625
4.390625
5.7734375

10101
2.1640625
10.1796875
10.4609375
8.78515625
4.109375
3.91015625

10103
10.51953125
11.26953125
9.9453125
8.38671875
4.4375
27.875

10105
1.84765625
14.328125
15.18359375
12.8515625
5.609375
4.96484375

10108
1.35546875
9.640625
10.15625
8.3515625
1.390625
2.0703125

10109
2.66796875
14.10546875
9.7578125
10.49609375
2.92578125
3.72265625

10110
1.6953125
11.41015625
9.41796875
10.2734375
3.546875
3.359375

10111
15.5703125
13.90625
11.8203125
14.84375
4.578125
4.89453125

10112
11.8203125
19.7890625
17.75
16.6953125
5.65625
0.16015625

10113
11.375
14.57421875
12.0546875
0.359375
11.22265625
1.7890625

CRT dAmax
CN dAmax
CN + 75tPA dAmax
CN + 150tPA dAmax
CFF dAmax
CFF + TXA dAmax

Patient ID
(mm)
(mm)
(mm)
(mm)
(mm)
(mm)

10096
0.984375
1.03125
1.03125
1.1015625
0.5390625
0.609375

10098
1.1953125
1.4296875
1.3359375
1.2421875
0.5390625
0.3984375

10100
1.7578125
1.265625
1.0078125
0.984375
0.65625
0.703125

10101
1.40525
1.453125
1.359375
1.3828125
0.9375
0.8203125

10103
1.3828125
1.4296875
1.3125
0.7265625
1.125
1.921875

10105
1.6640625
0.9375
1.2421875
1.453125
0.75
0.6796875

10108
0.9140625
1.3125
1.359375
1.5
0.65625
0.375

10109
1.8515625
1.1953125
1.640625
1.3828125
0.8203125
0.7265625

10110
1.828125
1.0546875
1.3359375
1.40625
0.84375
0.75

10111
1.78125
1.734375
1.734375
1.96875
1.078125
0.8203125

10112
3.84375
0.75
0.5625
0.84375
0.890625
0.0703125

10113
0.703125
0.3515625
0.234375
0.46875
4.1015625
0.28125

CN + 75tPA
CN + 150tPA

CFF + TXA

Patient ID
CRT LY30
CN LY30
LY30
LY30
CFF LY30
LY30
CRT CL30
CN CL30

10096
0.02673739
0.023091276
0.022254736
0.04494031
0.002878275
−8.86E−04
0.94254849
0.94822627

10098
0.028060208
0.025009675
0.019210477
0.024390248
−0.011732456
−0.002473245
0.940722324
0.950413223

10100
0.032283943
0.019990945
0.064302843
0.563915151
−0.011968085
−0.023366468
0.93889019
0.960423027

10101
0.023396867
0.017267276
0.079153977
0.54122007
−0.005733012
−0.005837346
0.953537356
0.957810852

10103
0.019735192
0.020560912
0.068618434
0.441085434
0.011639684
−9.79E−04
0.955545102
0.951049749

10105
0.0298312
0.028208719
0.241447525
0.672740198
0.004960784
−0.00922619
0.934773634
0.940271493

10108
0.021454126
0.024958008
0.562259963
0.618193856
0.022240969
0.017528496
0.949289454
0.946223709

10109
0.022353396
0.012313169
0.035683892
0.524804696
−0.006783194
−2.86E−04
0.955635641
0.967517948

10110
0.022358013
0.020903184
0.021046184
0.180870505
0.016776178
0.009773535
0.940199336
0.954335119

10111
0.022739705
0.01260451
0.021232989
0.247648005
−0.016114207
−0.018321366
0.955622328
0.96779679

10112
0.879012492
0.027216533
0.072425928
0.479522205
0.002217401
0
0.001807286
0.932567433

10113
0.046618911
0.009909361
0.266667805
0.752061229
0.024084025
0.009252843
0.902624631
0.960064935

CFTX dV @ CFF max

Patient ID
CN + 75tPA CL30
CN + 150tPA CL30
CFF CL30
CFF + TXA CL30
(mm/min)

10096
0.946060094
0.883149569
1.012377023
1.001882648
0.140625

10098
0.95467033
0.951698783
1.025506073
1.002349256
−0.140625

10100
0.812434994
0.002742494
1.042253521
1.110785463
0

10101
0.764648556
0.003959275
1.013483146
1.009630819
0.140625

10103
0.800613121
0.050084034
0.987616951
1.175849941
0.140625

10105
0.317701785
0.002394493
0.990294118
1.015306122
0.140625

10108
0.002127094
0.002118644
0.952564597
0.962468724
0.140625

10109
0.890828621
0.002124552
1.011545863
1.000974342
−0.140625

10110
0.955077211
0.406577693
0.977374014
0.988277087
0.28125

10111
0.955553117
0.240700717
1.036960986
1.055392732
0

10112
0.805960437
0.014771261
0.999198932
1
0

10113
0.328871893
0.00530504
0.935515388
0.984008529
−0.140625

CN dV @ CN + tPA75 max
CRT dA Integration to Acrit
CN dA Integration to Acrit

Patient ID
(mm/min)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10096
0.28125
137.9168701
152.5968018

10098
0.140625
18.10931396
85.04241943

10100
0.28125
30.77545166
142.5476074

10101
0.28125
24.70935059
126.7272949

10103
0.140625
148.2346802
139.7114868

10105
0.28125
21.95892334
119.911377

10108
0.703125
9.876159668
112.7658691

10109
0.140625
41.13446045
152.0645142

10110
0.140625
19.80834961
116.5907593

10111
0.140625
248.6063232
218.4060059

10112
0.140625
332.9483643
130.4747314

10113
0.5625
74.6619873
36.29608154

CN + 75tPA dA Integration to Acrit
CN + 150tPA dA Integration to Acrit
CFF dA Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)
(mm{circumflex over ( )}2)

10096
114.3511963
138.5315552
17.31170654

10098
88.23614502
99.55096436
6.07598877

10100
103.4598999
133.3125
24.56433105

10101
113.6920166
106.6964722
35.62536621

10103
101.5993652
47.87127686
44.81103516

10105
157.7796021
169.5179443
29.953125

10108
135.2076416
114.6643066
8.041992187

10109
124.2454834
133.0438843
18.23126221

10110
93.62493896
127.8973389
25.58605957

10111
173.4334717
267.8873291
41.30090332

10112
66.29699707
118.8896484
39.0135498

10113
14.78869629
0.046142578
11.96575928

CFF + TXA dA

Integration to Acrit

Patient ID
(mm{circumflex over ( )}2)
ID
SBP
HR
OR?
ICU?
Death?
pRBC
FFP
PLT
CRYO
CN Crit Prod

10096
22.05615234
10096
100
96
Yes
Yes
No
0
0
0
0
16.66113281

10098
8.37322998
10098
108
112
No
Yes
No
0
0
0
0
9.175689697

10100
35.33862305
10100
Unk
Unk
Yes
0
No
0
0
0
0
16.65087891

10101
27.97064209
10101
110
110
Yes
0
No
0
0
0
0
14.7923584

10103
134.5023193
10103
123
92
No
0
No
0
0
0
0
16.11190796

10105
20.06707764
10105
0
0
Yes
Yes
No
0
0
0
0
13.43261719

10108
7.827758789
10108
150
90
No
Yes
No
0
0
0
0
12.65332031

10109
18.26751709
10109
92
110
Yes
Yes
No
0
2
0
0
16.86044312

10110
21.515625
10110
100
92
Yes
Yes
No
0
0
0
0
12.03414917

10111
29.56256104
10111
115
70
No
Yes
No
0
0
0
0
24.11865234

10112
0.014831543
10112
210
142
No
Yes
No
0
0
0
0
14.84179688

10113
3.978149414
10113
110
110
No
Yes
No
0
0
0
0
5.123748779

Patient ID

10096

10098

10100

10101

10103

10105

10108

10109

10110

10111

10112

10113

	Number	Date	Country
	62172535	Jun 2015	US
	62172951	Jun 2015	US

Time Independent Viscoelastic Analysis Parameter for Prediction of Patient Outcome

Information

Publication Number

Date Filed

Date Published

Inventors

Original Assignees

CPC

International Classifications

Abstract

Description

Claims

CROSS-REFERENCE TO RELATED APPLICATIONS

PCT Information

Provisional Applications (2)