Claims
- 1. An implant composition for stimulating bone growth, comprising:
(a) a first calcium sulfate compound; (b) polymer containing particles comprising a second calcium sulfate compound, and at least one resorbable polymer of poly(desaminotyrosyl-tyrosine alkyl ester carbonate); and (c) a setting agent for setting said first calcium sulfate compound and said polymer containing particles into a heterogeneous solid composition; wherein upon setting, said first calcium sulfate compound forms a matrix and said polymer containing particles are settled within said matrix.
- 2. The implant composition of claim 1, wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) has an alkyl group having one to ten carbon atoms.
- 3. The implant composition of claim 2, wherein said wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) includes poly(desaminotyrosyl-tyrosine ethyl ester carbonates), poly(desaminotyrosyl-tyrosine butyl ester carbonates), poly(desaminotyrosyl-tyrosine hexyl ester carbonates), and poly(desaminotyrosyl-tyrosine octyl ester carbonates).
- 4. The implant composition of claim 1, wherein said second calcium sulfate compound in said polymer containing particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 5. The implant composition of claim 1, wherein the amount of said resorbable polymer in said polymer containing particle is in a range from about 0.1% to about 50% (w/w) of said composition.
- 6. A kit of implant materials for bone augmentation and bone defect reparation comprising:
(a) dry powder of a first calcium sulfate compound, and (b) polymer containing particles comprising a second calcium sulfate compound, and at least one resorbable polymer of poly(desaminotyrosyl-tyrosine alkyl ester carbonate).
- 7. The kit of implant materials of claim 6, wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) has an alkyl group that has one to ten carbon atoms.
- 8. The kit of implant materials of claim 6, wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) includes poly(desaminotyrosyl-tyrosine ethyl ester carbonates), poly(desaminotyrosyl-tyrosine butyl ester carbonates), poly(desaminotyrosyl-tyrosine hexyl ester carbonates), and poly(desaminotyrosyl-tyrosine octyl ester carbonates).
- 9. The kit of implant materials of claim 6, wherein size of said polymer containing particles is more than 20 μm in diameter.
- 10. The kit of implant materials of claim 6, wherein said second calcium sulfate compound in said polymer containing particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 11. The kit of implant materials of claim 6, wherein said resorbable polymer is mixed with said calcium sulfate compound of said particles.
- 12. The kit of implant materials of claim 6, wherein said calcium sulfate compound of said particles is coated with a resorbable polymer coating.
- 13. The kit of implant materials of claim 12, wherein thickness of said resorbable polymer coating is from about 2 μm to about 50 μm.
- 14. The kit of implant materials of claim 6, wherein the amount of said resorbable polymer in said polymer containing particle is in a range from about 0.1% to about 30% (w/w).
- 15. The kit of implant materials of claim 6, wherein said kit comprises two different polymer containing particles that resorb at different rates in a recipient site.
- 16. The kit of implant materials of claim 6 further comprising a setting agent, packed in a container.
- 17. An implant composition for stimulating bone growth, comprising:
(a) a calcium sulfate compound; (b) resorbable polymer coated particles, wherein said resorbable polymer is at least one of poly(desaminotyrosyl-tyrosine alkyl ester carbonate); and (c) a setting agent for setting said calcium sulfate compound and said resorbable polymer coated particles into a heterogeneous solid composition; wherein upon setting, said calcium sulfate compound forms a matrix and said resorbable polymer coated particles are settled within said matrix.
- 18. The implant composition of claim 17, wherein said matrix and said resorbable polymer coated particles resorb at different rates in a recipient site, and resorption of said resorbable polymer coated particles being slower.
- 19. The implant composition of claim 17, wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) has an alkyl group that has one to ten carbon atoms.
- 20. The implant composition of claim 19, said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) includes poly(desaminotyrosyl-tyrosine ethyl ester carbonates), poly(desaminotyrosyl-tyrosine butyl ester carbonates), poly(desaminotyrosyl-tyrosine hexyl ester carbonates), and poly(desaminotyrosyl-tyrosine octyl ester carbonates).
- 21. The implant composition of claim 17, wherein said resorbable polymer coated particles comprise:
(a) a calcium sulfate compound, and (b) a polymer coating with at least one of said resorbable polymer.
- 22. The implant composition of claim 21, wherein said calcium sulfate compound in said resorbable polymer coated particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 23. The implant composition of claim 21, wherein thickness of said polymer coating is from about 2 μm to about 50 μm.
- 24. A kit of implant materials for bone augmentation and bone defect reparation comprising:
(a) dry powder of a calcium sulfate compound, and (b) resorbable polymer coated particles, wherein said resorbable polymer is one of poly(desaminotyrosyl-tyrosine alkyl ester carbonate).
- 25. The kit of implant materials of claim 24, wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) has an alkyl group that has one to ten carbon atoms.
- 26. The kit of implant materials of claim 24, wherein said poly(desaminotyrosyl-tyrosine alkyl ester carbonate) includes poly(desaminotyrosyl-tyrosine ethyl ester carbonates), poly(desaminotyrosyl-tyrosine butyl ester carbonates), poly(desaminotyrosyl-tyrosine hexyl ester carbonates), and poly(desaminotyrosyl-tyrosine octyl ester carbonates).
- 27. The kit of implant materials of claim 24, wherein said resorbable polymer coated particles comprise:
(a) a calcium sulfate compound, and (b) a polymer coating with at least one of said resorbable polymer.
- 28. The kit of implant materials of claim 27, wherein size of said resorbable polymer coated particles is more than 20 μm in diameter.
- 29. The kit of implant materials of claim 27, wherein said calcium sulfate compound in said resorbable polymer coated particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 30. The kit of implant materials of claim 27, wherein thickness of said polymer coating is from about 2 μm to about 50 μm.
- 31. The kit of implant materials of claim 27, wherein the amount of said resorbable polymer in said resorbable polymer coated particles is in a range from about 0.1% to about 30% (w/w).
- 32. The kit of implant materials of claim 24, wherein said kit comprises two different resorbable polymer coated particles that resorb at different rates in a recipient site.
- 33. The kit of implant materials of claim 24 further comprising a setting agent, packed in a container.
- 34. The kit of implant materials of claim 33, wherein said setting agent is selected from the group consisting of water, an alkaline metal salt solution, and a potassium salt solution.
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application is a continuation-in-part of patent application Ser. No. 09/918,445, filed on Dec. 19, 2001, which claims the benefit under 35 USC 119 (e) of the provisional patent application Ser. No. 60/223,624, filed on Aug. 7, 2000. All prior applications are herein incorporated by reference in their entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60223624 |
Aug 2000 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09918445 |
Aug 2001 |
US |
Child |
10892509 |
Jul 2004 |
US |