Claims
- 1. An implant composition for stimulating bone growth, comprising:(a) a first calcium sulfate compound, (b) polymer containing particles comprising a second calcium sulfate compound, and at least one resorbable polymer, and (c) a setting agent for setting said calcium sulfate compound and said polymer containing particles into a heterogeneous solid composition, wherein upon setting, said calcium sulfate compound forms a matrix and said polymer containing particles are settled within said matrix.
- 2. The implant composition of claim 1, wherein a rate of resorption of said implant composition in a recipient site is in a range from about four weeks to about twenty eight weeks.
- 3. The implant composition of claim 1, wherein said matrix and said polymer containing particles resorb at different rates in a recipient site, and resorption of said polymer containing particles being slower.
- 4. The implant composition of claim 1, wherein said first calcium sulfate compound is calcium sulfate hemihydrate.
- 5. The implant composition of claim 1, wherein said setting agent is selected from the group consisting of water, an alkaline metal salt solution, and a potassium salt solution.
- 6. The implant composition of claim 1, wherein size of said polymer containing particles is more than 20 μm in diameter.
- 7. The implant composition of claim 1, wherein said second calcium sulfate compound in said polymer containing particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 8. The implant composition of claim 1, wherein said resorbable polymer is mixed with said calcium sulfate compound of said particles.
- 9. The implant composition of claim 1, wherein said calcium sulfate compound of said particles is coated with a resorbable polymer coating.
- 10. The implant composition of claim 9, wherein thickness of said resorbable polymer coating is from about 2 μm to about 50 μm.
- 11. The implant composition of claim 1, wherein said resorbable polymer is aliphatic polyesters of alpha-hydroxy acid derivatives.
- 12. The implant composition of claim 11, wherein said resorbable polymer is selected from the group consisting of polyactides, polyglycolides, polydioxanone, and poly ε-caprolactone.
- 13. The implant composition of claim 11, wherein said resorbable polymer is polyactides.
- 14. The implant composition of claim 1, wherein said resorbable polymer is a poly(desaminotyrosyl-tyrosine ethyl ester carbonate).
- 15. The implant composition of claim 1, wherein said resorbable polymer is selected from the group consisting of hydrophobic polymers, carnuba waxes, water soluble polymers, polyvinyl alcohols, and therapeutic polymers containing salicylates.
- 16. The implant composition of claim 1, wherein the amount of said resorbable polymer in said polymer containing particle is in a range from about 0.1% to about 50% (w/w).
- 17. A kit of implant materials for bone augmentation and bone defect reparation comprising:(a) dry powder of a first calcium sulfate compound, and (b) polymer containing particles comprising a second calcium sulfate compound, and at least one resorbable polymer.
- 18. The kit of implant materials of claim 17, wherein said first calcium sulfate compound is calcium sulfate hemihydrate.
- 19. The kit of implant materials of claim 17, wherein size of said polymer containing particles is more than 20 μm in diameter.
- 20. The kit of implant materials of claim 17, wherein said second calcium sulfate compound in said polymer containing particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 21. The kit of implant materials of claim 17, wherein said resorbable polymer is mixed with said calcium sulfate compound of said particles.
- 22. The kit of implant materials of claim 17, wherein said calcium sulfate compound of said particles is coated with a resorbable polymer coating.
- 23. The kit of implant materials of claim 22, wherein thickness of said resorbable polymer coating is from about 2 μm to about 50 μm.
- 24. The kit of implant materials of claim 17, wherein said resorbable polymer is aliphatic polyesters of alpha-hydroxy acid derivatives.
- 25. The kit of implant materials of claim 24, wherein said resorbable polymer is selected from the group consisting of polyactides, polyglycolides, polydioxanone, and poly ε-caprolactone.
- 26. The kit of implant materials of claim 24, wherein said resorbable polymer is polyactides.
- 27. The kit of implant materials of claim 17, wherein said resorbable polymer is a poly(desaminotyrosyl-tyrosine ethyl ester carbonate).
- 28. The kit of implant materials of claim 17, wherein said resorbable polymer is selected from the group consisting of hydrophobic polymers, carnuba waxes, water soluble polymers, polyvinyl alcohols, and therapeutic polymers containing salicylates.
- 29. The kit of implant materials of claim 17, wherein the amount of said resorbable polymer in said polymer containing particle is in a range from about 0.1% to about 30% (w/w).
- 30. The kit of implant materials of claim 17, wherein said kit comprises two different polymer containing particles that resorb at different rates in a recipient site.
- 31. The kit of implant materials of claim 17 further comprising a setting agent, packed in a container.
- 32. The kit of implant materials of claim 31, wherein said setting agent is selected from the group consisting of water, an alkaline metal salt solution, and a potassium salt solution.
- 33. The kit of implant materials of claim 17 further comprising instructions on how to use the kit.
- 34. A method for bone augmentation and bone defect reparation comprising the steps of:(a) mixing a calcium sulfate compound and resorbable polymer coated particles with a setting agent into a mixture, (b) applying said mixture, and (c) setting said mixture into a heterogeneous solid composition, wherein upon setting, said calcium sulfate compound forms a matrix and said resorbable polymer coated particles settled within said matrix; wherein said heterogeneous solid composition resorbs at a controlled rate in a recipient site for stimulating bone growth.
- 35. The method of claim 34, wherein applying said mixture is filling a recipient site with said mixture.
- 36. The method of claim 34, wherein applying said mixture is coating said mixture on a surface of a surgical implant prior to introducing said surgical implant into said recipient site.
- 37. The method of claim 34, wherein said setting agent controls a speed of setting said mixture into a heterogeneous solid composition.
- 38. The method of claim 37, wherein said setting agent is selected from the group consisting of water, an alkaline metal salt solution, and a potassium salt solution.
- 39. The method of claim 34, wherein said resorbable polymer coated particles resorbable polymer coated particles that resorb at different rates in a recipient site.
- 40. An implant composition for stimulating bone growth, comprising:(a) a calcium sulfate compound, (b) resorbable polymer coated particles, and (c) a setting agent for setting said calcium sulfate compound and said resorbable polymer coated particles into a heterogeneous solid composition, wherein upon setting, said calcium sulfate compound forms a matrix and said resorbable polymer coated particles are settled within said matrix.
- 41. The implant composition of claim 40, wherein said matrix and said resorbable polymer coated particles resorb at different rates in a recipient site, and resorption of said resorbable polymer coated particles being slower.
- 42. The implant composition of claim 41, wherein a rate of resorption of said implant composition in a recipient site is in a range from about four weeks to about twenty eight weeks.
- 43. The implant composition of claim 41, wherein said calcium sulfate compound is calcium sulfate hemihydrate.
- 44. The implant composition of claim 41, wherein said setting agent is selected from the group consisting of water, an alkaline metal salt solution, and a potassium salt solution.
- 45. The implant composition of claim 41, wherein said resorbable polymer coated particles comprise:(a) a calcium sulfate compound, and (b) a polymer coating with at least one resorbable polymer.
- 46. The implant composition of claim 45, wherein size of said resorbable polymer coated particles is more than 20 μm in diameter.
- 47. The implant composition of claim 45, wherein said calcium sulfate compound in said resorbable polymer coated particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 48. The implant composition of claim 47, wherein thickness of said polymer coating is from about 2 μm to about 50 μm.
- 49. The implant composition of claim 48, wherein said resorbable polymer is aliphatic polyesters of alpha-hydroxy acid derivatives.
- 50. The implant composition of claim 49, wherein said resorbable polymer is selected from the group consisting of polyactides, polyglycolides, polydioxanone, and poly ε-caprolactone.
- 51. The implant composition of claim 49, wherein said resorbable polymer is polyactides.
- 52. The implant composition of claim 48, wherein said resorbable polymer is a poly(desaminotyrosyl-tyrosine ethyl ester carbonate).
- 53. The implant composition of claim 48, wherein said resorbable polymer is selected from the group consisting of hydrophobic polymers, carnuba waxes, water soluble polymers, polyvinyl alcohols, and therapeutic polymers containing salicylates.
- 54. The implant composition of claim 48, wherein the amount of said resorbable polymer in said resorbable polymer coated particles is in a range from about 0.1% to about 50% (w/w).
- 55. A kit of implant materials for bone augmentation and bone defect reparation comprising:(a) dry powder of a calcium sulfate compound, and (b) resorbable polymer coated particles.
- 56. The kit of implant materials of claim 55, wherein said calcium sulfate compound is calcium sulfate hemihydrate.
- 57. The kit of implant materials of claim 55, wherein said resorbable polymer coated particles comprise:(a) a calcium sulfate compound, and (b) a polymer coating with at least one resorbable polymer.
- 58. The kit of implant materials of claim 57, wherein size of said resorbable polymer coated particles is more than 20 μm in diameter.
- 59. The kit of implant materials of claim 57, wherein said calcium sulfate compound in said resorbable polymer coated particles is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, and mixture thereof.
- 60. The kit of implant materials of claim 59, wherein thickness of said polymer coating is from about 2 μm to about 50 μm.
- 61. The kit of implant materials of claim 60, wherein said resorbable polymer is aliphatic polyesters of alpha-hydroxy acid derivatives.
- 62. The kit of implant materials of claim 61, wherein said resorbable polymer is one selected from the group consisting of polyactides, polyglycolides, polydioxanone, and poly ε-caprolactone.
- 63. The kit of implant materials of claim 61, wherein said resorbable polymer is polyactides.
- 64. The kit of implant materials of claim 60, wherein said resorbable polymer is a poly(desaminotyrosyl-tyrosine ethyl ester carbonate).
- 65. The kit of implant materials of claim 60, wherein said resorbable polymer is selected from the group consisting of hydrophobic polymers, carnuba waxes, water soluble polymers, polyvinyl alcohols, and therapeutic polymers containing salicylates.
- 66. The kit of implant materials of claim 60, wherein the amount of said resorbable polymer in said resorbable polymer coated particles is in a range from about 0.1% to about 30% (w/w).
- 67. The kit of implant materials of claim 57, wherein said kit comprises two different resorbable polymer coated particles that resorb at different rates in a recipient site.
- 68. The kit of implant materials of claim 57, further comprising a setting agent, packed in a container.
- 69. The kit of implant materials of claim 68, wherein said setting agent is selected from the group consisting of water, an alkaline metal salt solution, and a potassium salt solution.
REFERENCE TO RELATED APPLICATION
This application corresponds in part to the subject matter to that of Provisional Application serial No. 60/223,624, filed Aug. 7, 2000, which is herein incorporated by reference in its entirety.
US Referenced Citations (6)
Provisional Applications (1)
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Number |
Date |
Country |
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60/223624 |
Aug 2000 |
US |