Claims
- 1. A composition comprising a pharmaceutically acceptable formulation of an indole of formula
- 2. The composition of claim 1 wherein R3 to R7,and Y1 are independently selected from the group consisting of —H, C1-C5 alkoxyl, C1-C5 polyalkoxyalkyl, C1-C10 polyhydroxyalkyl, C5-C20 polyhydroxyaryl, mono- and disaccharides, nitro, hydrophilic peptides, arylpolysulfonates, C1-C5 alkyl, C1-C10 aryl, —SO3T, —CO2T, —OH, —(CH2)aSO3T, —(CH2)aOSO3T, —(CH2)aNHSO3T, —(CH2)aCO2(CH2)bSO3T, —(CH2)aOCO(CH2)bSO3T, —CH2(CH2—O—CH2)c—CH2—OH, —(CH2)d—CO2T, —CH2—(CH2—O—CH2)e—CH2—CO2T, —(CH2)f—NH2, —CH2—(CH2—O—CH2)g—CH2—NH2, —(CH2)h—N(Ra)—(CH2)i—CO2T, and —(CH2)j—N(Rb)—CH2—(CH2—O—CH2)k—CH2—CO2T; W1 is selected from the group consisting of —CRcRd, —O—, and —NRc; a, b, d, f, h, l, and j independently vary from 1-5; c, e, g, and k independently vary from 1-20; Ra, Rb, Rc, and Rd are defined in the same manner as Y1; T is a negative charge.
- 3. The composition of claim 2 wherein each R3, R4, R6 and R7 is H, R5 is SO3T, Y1 is —(CH2)3SO3T; W1 is —C(CH3)2; T is a negative charge.
- 4. A method for performing a diagnostic procedure which comprises administering to an individual an effective amount of the indole of formula
- 5. The method for performing the diagnostic or therapeutic procedure of claim 4 which comprises administering to an individual an effective amount of the composition of indoles wherein R3 to R7, and Y1 are independently selected from the group consisting of C1-C5 alkoxyl, C1-C5 polyalkoxyalkyl, C1-C10 polyhydroxyalkyl, C5-C20 polyhydroxyaryl, mono- and disaccharides, nitro, hydrophilic peptides, arylpolysulfonates, C1-C10 aryl, —SO3T, —CO2T, —OH, —(CH2)aSO3T, —(CH2)aOSO3T, —(CH2)aNHSO3T, —(CH2)aCO2(CH2)bSO3T, —(CH2)aOCO(CH2)bSO3T, —CH2(CH2—O—CH2)c—CH2—OH, —(CH2)d—CO2T, —CH2—(CH2—O—CH2)e—CH2—CO2T, —(CH2)f—NH2, —CH2—(CH2—O—CH2)g—CH2—NH2, —(CH2)h—N(Ra)—(CH2)i—CO2T, and —(CH2)j—N(Rb)—CH2—(CH2—O—CH2)k—CH2—CO2T; W1 is selected from the group consisting of —CRcRd, —O—, and —NRc; a, b, d, f, h, l, and j independently vary from 1-5; c, e, g, and k independently vary from 1-20; Ra, Rb, Rc, and Rd are defined in the same manner as Y1; T is a negative charge.
- 6. The method for performing the diagnostic or therapeutic procedure of claim 5 which comprises administering to an individual an effective amount of the composition of indoles wherein each R3, R4, R6 and R7 is H, R5 is SO3T, Y1 is —(CH2)3SO3T; W1 is —C(CH3)2; T is a negative charge.
- 7. The method of claim 4 wherein said procedure utilizes light of wavelength in the region of 350-1300 nm.
- 8. The method of claim 4 wherein said diagnostic procedure comprises monitoring a blood clearance profile by fluorescence wherein light of wavelength in the region of 350 to 1300 nm is utilized.
- 9. The method of claim 4 wherein said diagnostic procedure comprises monitoring a blood clearance profile by absorption wherein light of wavelength in the region of 350 to 1300 nm is utilized.
- 10. The method of claim 4 wherein said procedure is for physiological function monitoring.
- 11. The method of claim 10 wherein the diagnostic procedure is for renal function monitoring.
- 12. The method of claim 10 wherein the diagnostic procedure is for cardiac function monitoring.
- 13. The method of claim 10 wherein the diagnostic procedure is for kidney function monitoring.
- 14. The method of claim 10 wherein the diagnostic procedure is for determining organ perfusion in vivo.
- 15. A composition comprising a pharmaceutically acceptable formulation of an indole of formula
- 16. A method for performing a diagnostic procedure which comprises administering to an individual an effective amount of the indole of formula
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a Divisional of U.S. patent application Ser. No. 09/688,949, filed on Oct. 16, 2000, now pending, the disclosure of which is hereby incorporated by reference in its entirety.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09688649 |
Oct 2000 |
US |
Child |
10814404 |
Mar 2004 |
US |