TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responses

Information

  • Research Project
  • 10179420
  • ApplicationId
    10179420
  • Core Project Number
    P20GM113131
  • Full Project Number
    5P20GM113131-05
  • Serial Number
    113131
  • FOA Number
    PAR-14-035
  • Sub Project Id
    6054
  • Project Start Date
    8/1/2017 - 6 years ago
  • Project End Date
    5/31/2022 - 2 years ago
  • Program Officer Name
  • Budget Start Date
    6/1/2021 - 3 years ago
  • Budget End Date
    5/31/2022 - 2 years ago
  • Fiscal Year
    2021
  • Support Year
    05
  • Suffix
  • Award Notice Date
    6/14/2021 - 3 years ago

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responses

The innate immune response to pathogens involves the expression and secretion of inflammatory cytokines that act to facilitate eradication of the infecting pathogen. The dysregulation of cytokine production (chronic inflammation) can have negative effects on the host. Therefore, a fundamental understanding of the molecular mechanisms regulating inflammation is essential for the development of therapeutic approaches for inflammatory disorders. We identify a novel role for the transcription factor GLI3 in regulating cytokine expression in response to TLR-TRIF signaling. GLI3 KO in monocytes induces a phenotype that indicates GLI3 associates with inflammatory pathways in response to TLR-TRIF stimulation. In this proposal, we will further elucidate the role of GLI3 in regulating cytokine expression in monocytes and explore the relevance of this regulation in inflammatory responses.

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    P20
  • Administering IC
    GM
  • Application Type
    5
  • Direct Cost Amount
    201230
  • Indirect Cost Amount
    100739
  • Total Cost
  • Sub Project Total Cost
    301969
  • ARRA Funded
    False
  • CFDA Code
  • Ed Inst. Type
  • Funding ICs
    NIGMS:301969\
  • Funding Mechanism
    RESEARCH CENTERS
  • Study Section
    ZGM1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    UNIVERSITY OF NEW HAMPSHIRE
  • Organization Department
  • Organization DUNS
    111089470
  • Organization City
    DURHAM
  • Organization State
    NH
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    038242620
  • Organization District
    UNITED STATES