Claims
- 1. A vaccine comprising immunogenic material in an essentially mineral oil-free stable oil-in-water emulsion comprising tocols, wherein the vaccine contains from 0.1 to 40% by weight tocols and the tocols have the formula: ##STR4## wherein: R may be H or one or more of identical or different substituents chosen from the group consisting of alkyl, alkoxy, acyloxy, hydroxy, a sulphate and a phosphate group;
- R.sub.1 and R.sub.3 independently of one another are H or alkyl;
- R.sub.2 is H or alkyl and may be different in each unit;
- the broken line indicates the presence or absence of an additional carbon--carbon bond in a unit; and
- n has the value 1 to 10.
- 2. The vaccine according to claim 1, wherein the tocols have the formula: ##STR5## wherein: R.sub.4 may be hydroxy, an acyloxy group, a sulphate or a phosphate group; and
- R.sub.5 may be H or one to three identical or different alkyl groups with 1-4 carbon atoms.
- 3. The vaccine according to claim 2, wherein the tocol is 5, 7, 8-trimethyltocol acetate.
- 4. The vaccine according to claim 1, further comprising at least one other component having adjuvant action.
- 5. The vaccine according to claim 1, wherein the vaccine contains from 2.5 to 10% by weight tocols.
- 6. The vaccine according to claim 1, wherein the tocols are in the form of dispersed particles and said particles are no larger than 20 .mu.m.
- 7. An adjuvant mixture comprising a stable emulsion of tocols in water, wherein the tocols constitute 0.1 to 40% by weight of the adjuvant mixture.
- 8. The vaccine according to claim 5, wherein said particles are no larger than 1 .mu.m.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8900277 |
Feb 1989 |
NLX |
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Parent Case Info
This is a continuation of U.S. Ser. No. 08/007,400, filed Jan. 21, 1993, now abandoned, which is a file wrapper continuation of U.S. Ser. No. 07,474,434, filed Feb. 2, 1990, now abandoned.
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Date |
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3919411 |
Glass et al. |
Nov 1975 |
|
4650677 |
Roerink et al. |
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4772466 |
Allison et al. |
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|
4788056 |
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|
5151267 |
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|
Foreign Referenced Citations (1)
Number |
Date |
Country |
8702219 |
Apr 1987 |
WOX |
Continuations (2)
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Number |
Date |
Country |
Parent |
07400 |
Jan 1993 |
|
Parent |
474434 |
Feb 1990 |
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