Claims
- 1. A method of treating ocular hypertension for those in need thereof comprising administering to an affected eye between about 0.005 and about 5.0 percent by weight of a topical ophthalmic composition comprising a thiadiazole of formula: ##STR2## and optically active isomers and pharmacologically acceptable salts thereof, wherein R is selected from the group consisting of: hydrogen, halogen, C.sub.1-5 alkyl, C.sub.2-5 mono-alkenyl, C.sub.2-5 alkoxy, C.sub.3-6 cycloalkyl, phenyl, phenalkyl, morpholino, furyl, thienyl and pyrryl.
- 2. The method of claim 1, wherein R is selected from the group consisting of: chlorine, ethyl, allyl, cyclopropyl, ethoxy, phenyl, phenyl -chloromethyl and 2 -cyclopropyl methoxy) ethyl.
- 3. The method of claim 2, wherein R is ethyl.
- 4. The method of claim 2, wherein R is 2-(cyclopropylmethoxy)ethyl.
- 5. The method of claim 1, wherein the thiadiazole is present in an amount between about 0.1 and about 2.0 percent by weight.
- 6. The method of claim 5, wherein the thiadiazole is present in an amount of about 1.0 percent by weight.
- 7. The method of claim 1, further comprising an anionic mucomimetic polymer.
- 8. The method of claim 7, further comprising finely divided ion exchange resin.
Parent Case Info
This application is a continuation of application Ser. No. 07/939,540, filed Sep. 2, 1992, which is a continuation of application Ser. No. 07/776,544, filed Oct. 11, 1991 both now abandoned.
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Foreign Referenced Citations (2)
Number |
Date |
Country |
WO8402525 |
Jul 1984 |
WOX |
WO8807044 |
Sep 1988 |
WOX |
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Continuations (2)
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Number |
Date |
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Parent |
939540 |
Sep 1992 |
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Parent |
776544 |
Oct 1991 |
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