Claims
- 1. The compound of the formula, ##SPC6##
- wherein R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino;
- and the pharmaceutically-acceptable acid addition salts of basic members thereof.
- 2. The compound of claim 1, wherein R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkoxy and are the same.
- 3. The compound of claim 2, which compound is 3-chloro-5,6-bis(4-methoxyphenyl)-1,2,4-triazine.
- 4. The compound of claim 1, which compound is 3-chloro-5,6-bis(4-dimethylaminophenyl)-1,2,4-triazine.
- 5. The compound of claim 1, which compound is 3-chloro-5,6-bis(4-fluorophenyl)-1,2,4-triazine.
- 6. The compound of claim 1, which compound is 3-chloro-5,6-bis(4-chlorophenyl)-1,2,4-triazine.
- 7. A method of treating inflammation in a warm-blooded mammal which comprises topically administering to such mammal an effective amount of a compound of the formula, ##SPC7##
- wherein R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino;
- and the pharmaceutically acceptable acid addition salts of basic members thereof.
- 8. The method of claim 7, wherein such inflammation is induced by ultraviolet radiation.
- 9. The method of claim 8, wherein the compound is 3-chloro-5,6-bis(4-methoxyphenyl)-1,2,4-triazine.
- 10. The method of claim 8, wherein the compound is 3-chloro-5,6-bis(4-dimethylaminophenyl)-1,2,4-triazine.
- 11. The method of claim 8, wherein the compound is 3-chloro-5,6-bis(4-fluorophenyl)-1,2,4-triazine.
- 12. The method of claim 8, wherein the compound is 3-chloro-5,6-bis(4-chlorophenyl)-1,2,4-triazine.
- 13. The method of claim 8, wherein the compound is 3-chloro-5,6-bis(4-methylphenyl)-1,2,4-triazine.
- 14. The composition suitable for topically treating inflammation in a warm-blooded mammal which comprises a pharmaceutically acceptable carrier comprising one or more components at least one of which has a boiling point above about 95.degree. C. and constitutes from about 10 percent to 100 percent (w/w) of such carrier, and an effective amount of a compound of the formula, ##SPC8##
- wherein R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino; and the pharmaceutically acceptable acid addition salts of basic members thereof.
- 15. The composition of claim 14, wherein the compound is 3-chloro-5,6-bis(4-methoxyphenyl)-1,2,4-triazine.
- 16. The composition of claim 14, wherein the compound is 3-chloro-5,6-bis(4-dimethylaminophenyl)-1,2,4-triazine.
- 17. The composition of claim 14, wherein the compound is 3-chloro-5,6-bis(4-fluorophenyl)-1,2,4-triazine.
- 18. The composition of claim 14, wherein the compound is 3-chloro-5,6-bis(4-chlorophenyl)-1,2,4-triazine.
- 19. The composition of claim 14, wherein the compound is 3-chloro-5,6-bis(4-methylphenyl)-1,2,4-triazine.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of copending application Ser. No. 438,156, filed Jan. 31, 1974, now U.S. Pat. No. 3,948,894.
Non-Patent Literature Citations (1)
Entry |
polonovski et al., Chemical Abstracts, vol. 46, 514(b) 1952. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
438156 |
Jan 1974 |
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