Takimoto, "Antifolates in Clinical Development", Seminars in Oncology, 24(5), Supp. 18, S18-40--S18-51 (1997). |
Marsham et al., "Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors", J. Med. Chem., 42, 3809-3820 (1999). |
Cunningham et al., "Tomudex' (ZD 1694): Results of a Randomied Trial in Advanced Coloreactal Cancer Demonstrate Efficacy and Reduced Mucositis and Leucopenia", Eur. J. Cancer, 31A(12), 1945-1954 (1995). |
Jackman et al., "The Antitumour Activity of ZD9331, a Non-polyglutamatable Quinazoline Thymidylate Synthase Inhibitor", pp. 185-188 in Purine and Pyrimidine Metabolism in Man VIII, ed. Sahota and Taylor, Plenum Press, New York (1995). |
Wahba et al., "Direct Spectrophotometric Evidence for the Oxidation of Tetrahydrofolate During the Enzymatic Synthesis of Thymidylate", J. Biol. Chem., 236(3). PC11-PC12 (1961). |
Chen et al., "Inhibition of Thymidylate Synthase by Pyridoxal Phosphate", Int. J. Biochem., 21(11), 1217-1221 (1989). |
Lippmann et al., "The Effect of Estrogens and Antiestrogens on Hormone-responsive Human Breast Cancer in Long-Term Tissue Culture", Cancer Res., 36, 4595-4601 (1976). |
Fischer et al., "I. Development, Maintenance and Assay of Drug Resistance", Meth. Med. Res., 10, 247-262 (1964). |