Trajectory array guide system

Abstract

The present disclosure presents a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory. The trajectory array guide system can comprise: a base, an array guide, an imaging unit, and an elongated handle configured for connection with a stereotaxic navigation system. The present disclosure presents a method of using a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory.

Description

BACKGROUND

The present disclosure relates to brain surgery and more specifically to the field of trajectory array guides for placement of surgical tools used for delivery of therapeutic agents or measurement devices to specific locations in the brain.

Precise access to brain structures is frequently required for an assortment of indications, including tissue sampling, catheter or electrode placement, and localized drug delivery. The most common means of performing these procedures is to use either frame based or frameless stereotaxy. In either case, a preoperative imaging session is performed to characterize and localize the specific brain target. Magnetic resonance imaging (MRI) is the preferred technique for preoperative demarcation of brain structures due to the quality and range of tissue contrast that can be achieved. Utilization of previously acquired imaging information during surgery requires some system for registering the image data to the patient on the operating table. This may be achieved with an external frame that is visible on imaging or the identification of implanted markers or characteristic features in the frameless case. In either situation, target points are determined based on the previously acquired images and are used to guide the surgical procedure. This has disadvantages, as the registration process is imperfect and prone to error, and there is no ability to update the images to compensate for dynamic effects such as brain shift. Moreover, there is no opportunity to either confirm that the surgical goals have been met or to monitor deposition of a delivered therapeutic agent, physiological change or instrument operation during the procedure (Martin et al. J. Magn. Reson. Imaging, 2008, 27, 737-743).

An alternative to this traditional means of accessing brain structure is to immobilize the patient's head during imaging and perform the surgery within the magnetic resonance bore. This approach also has obvious disadvantages, most notably the physical presence of the magnet and the corresponding magnetic field. However, it overcomes the need for registration and permits intraprocedural image updates. It also may provide novel insight into the guidance, administration, and evaluation of interventions and therapies. There are several different means of performing stereotactic procedures within an MRI system. Lower field, open systems, afford some degree of line-of-site and therefore instruments can be tracked in a manner analogous to conventional frameless stereotaxy without moving the head out of the MRI system. The orientation of these tracked devices can further be used to prescribe the slice in which imaging is to be performed. In closed bore systems it is much less practical to track devices via optical means. The magnetic resonance environment itself, however, permits opportunities to track and visualize devices either by passive or active means. The latter is achieved by integrating microcoils into the appropriate surgical tools and tracking their position within the bore via MR methods. Passive methods simply require that the device be visible within acquired images either by positive or negative contrast.

Prospective stereotaxy is a technique for aligning a trajectory array guide within a magnetic resonance system. The general approach requires that a patient be immobilized within the magnetic resonance scanner and a trajectory array guide be mounted on a rigid surface such as the skull. Imaging is then performed to define the desired trajectory, usually in two orthogonal planes, from the entry point to the remote target. The trajectory array guide is aligned with real-time imaging followed by confirmatory scans to assure the intended path will be followed. This approach has been used to guide brain biopsy and the insertion of deep brain stimulator electrodes (Martin et al. J. Magn. Reson. Imaging, 2008, 27, 737-743).

The optimal trajectory is established by analyzing the magnetic resonance images of the brain, considering the location of the targeted segment of the brain, suitable entry point on the skull, and critical organs and vessels that need to be avoided (e.g. blood vessels) to minimize the risk of complications. Once the trajectory is established, a mounting system external to the head of the patient is used to position the catheter along the trajectory and guide the insertion of the catheter into the brain. This process tends to be iterative and involves image analysis of the actual trajectory of the mounting system versus the desired trajectory. Repositioning of the mounting system is typically required until the actual trajectory coincides with the desired trajectory.

A number of efforts have been made to develop trajectory array guide systems for delivery of elongated tools such as catheters to target locations in the brain. Examples of such systems and related tools are disclosed in U.S. Pat. Nos. 9,042,958, 8,845,665, 7,981,120, 8,845,656, and 8,591,522 and in published U.S. Patent Application Nos. 20150100064 and 20010014771, each of which is incorporated herein by reference in its entirety.

Many challenges remain with regard to development of trajectory array guide systems. A number of such challenges are addressed by various embodiments of the present disclosure.

SUMMARY

The present disclosure provides a trajectory array guide system and kit as well as a method for delivering an elongated tool to a target location in the brain of a subject.

The present disclosure provides a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory. In some embodiments, the trajectory array guide system includes: a combination of a base and an array guide in a lockable ball-socket pivoting mechanism, wherein the base is configured for attachment to the skull of a subject and the array guide is defined by a series of lumens or is defined by a bore configured to hold a separate array unit defined by a series of lumens; an imaging unit configured for engagement with the array guide and configured to hold and direct imaging fluid along passages which are co-axial with the lumens of the array guide for the purpose of defining a series of trajectories; and an elongated handle having sufficient length for connection to an image-guided stereotaxic navigation system, the handle configured for attachment to either the array guide or the imaging unit.

In some embodiments, the trajectory array guide system includes an array guide. In some embodiments, the array guide includes a ball component. In some embodiments, the trajectory array guide system also includes a base which includes a socket configured to receive and hold the ball of the array guide. In some embodiments, the socket has a central axis orthogonal to a plane formed by the bottom of the base. In some embodiments, the socket has a central axis which is non-orthogonal with respect to the plane formed by the bottom of the base, thereby providing a tilted socket. In some embodiments, the tilted socket increases the angle range of a series of trajectories. In some embodiments, the central axis of the socket is angled by about 10 to about 30 degrees from the axis orthogonal to the plane formed by the bottom of the base.

In some embodiments, the trajectory array guide system includes a socket which has an outer sidewall. In some embodiments, the outer sidewall includes threads or one or more grooves configured for attachment to a locking element. In some embodiments, the locking element prevents pivoting movement of a ball within the socket when the locking element is engaged to the outer sidewall of the socket. In some embodiments, the locking element is a ring-clamp configured for connection to the one or more grooves. In some embodiments, the locking element is a locking nut configured for connection to the threads.

In some embodiments, the trajectory array guide system includes a base which includes a plurality of attachment members. In some embodiments, the plurality of attachment members are accessible by an attachment tool for attaching the base to the skull of a subject.

In some embodiments, the trajectory array guide system includes an array guide which is a generally cylindrical or funnel-shaped member with openings at both ends, having a ball formed at one end and a series of lumens extending longitudinally along the length of the array guide between the openings at both ends. In some embodiments, the series of lumens includes seven substantially parallel lumens with six lumens arranged in a symmetrical hexagonal pattern and a seventh lumen located in the center of the symmetrical hexagonal pattern. In some embodiments, the trajectory array guide system further includes an imaging unit which includes an upper reservoir in fluid communication with a series of lower extensions which are co-axial with the lumens of the array guide. In some embodiments, the lower extensions are tubes configured to fit inside the lumens of the array guide. In some embodiments, the array guide includes an outer groove and the imaging unit includes an index tube configured to slide into the outer groove when the imaging unit is engaged with the array guide. In some embodiments, the index tube is provided as a reference point for identification of each of the tubes in magnetic resonance images. In some embodiments, the imaging unit includes a cap to seal the imaging fluid inside the imaging unit. In some embodiments, the array guide includes a locking mechanism for locking the tubes in place within the array guide. In some embodiments, the locking mechanism includes at least one set-screw which penetrates the array guide and makes tightening contact with at least one of the tubes. In some embodiments, the locking system includes three set-screws, each penetrating the body of the array guide to enter two different lumens as well as the seventh lumen. In some embodiments, the three set-screws are placed closer to the ball of the ball array guide than to the upper end of the ball array guide.

In some embodiments, the trajectory array guide system includes a handle. In some embodiments, the handle includes a connector end configured for attachment to the outside or the inside of an imaging unit. In some embodiments, the connector end is configured for attachment to the outside of the imaging unit and includes an opening for a connector set-screw to lock the handle on the imaging unit. In some embodiments, the handle includes an end spike for insertion into one of the lumens of a ball array guide for direct connection of the handle to the ball array guide. In some embodiments, the handle is at least partially hollow and has an outer end opening at the end opposite the end spike, the outer end opening configured for connection to a navigation pointer of an image guided surgery system.

In some embodiments, the trajectory array guide system includes a reducer tube for insertion into one of the lumens of an array guide. In some embodiments, the reducer tube provides a reduced diameter in the lumen for insertion of an elongated tool. In some embodiments, the reducer tube includes an adjustable stop for restraining movement of an elongated tool.

In some embodiments, the trajectory array guide system includes an array guide defined by a bore configured to hold a guide unit defined by a series of passages which are co-axial with the lumens of the array guide. In some embodiments, the guide unit includes an upper lock tab for connection of the guide unit to the array guide. In some embodiments, the trajectory array guide system includes an imaging unit configured for connection to the array guide at the upper lock tab. In some embodiments, the trajectory array guide system further includes a locking slider configured for insertion into the body of the guide unit to hold an elongated tool in place in one of the lumens.

In some embodiments, the trajectory array guide system includes an imaging unit engaged with a ball array guide. In some embodiments, the imaging unit includes a series of passages connected to a plenum located at about the center of rotation of the ball in a ball array guide. In some embodiments, the trajectory array guide system includes a handle with a channel for injecting imaging fluid into a central passage of the series of passages. In some embodiments, the imaging fluid flows through the central passage into the plenum, with subsequent upward filling of remaining passages of the series of passages via the plenum. In some embodiments, the passages are seven substantially parallel passages with six passages arranged in a symmetrical hexagonal pattern around the central passage. In some embodiments, one of the six passages is extended downward past the plenum for providing an index passage for identification of individual passages.

The present disclosure provides a method for delivering an elongated tool to a target location in the brain of a subject. In some embodiments, the method includes: a) providing a trajectory array guide system which includes a base plate, an array guide, an imaging unit, a handle and an image-guided stereotaxic navigation system connected to the handle; b) performing a craniotomy at an entry location; c) connecting the base of the trajectory array guide system to the entry location and engaging the array guide with the base plate; d) engaging the imaging unit with the array guide and aligning the array guide to the target; e) imaging a series of trajectories towards the target location with magnetic resonance imaging; f) locking the trajectory array guide system and selecting a trajectory from the series of trajectories: g) removing the imaging unit and delivering the elongated tool to the target location using the selected trajectory; and h) removing the trajectory array guide system from the skull of the subject. In some embodiments, the base of the trajectory array guide system is connected to the entry location using bone screws through bottom tabs in the base. In some embodiments, the method includes adding MRI contrast imaging reagent to the imaging unit before the step for imaging the series of trajectories. In some embodiments, the method includes using the stereotaxic navigation system to orient the series of trajectories toward the target location. In some embodiments, the elongated tool is a catheter. In some embodiments, the catheter is configured to deliver a drug to the target location.

In some embodiments, the method for delivering an elongated tool to a target location in the brain of a subject uses a trajectory array guide system of the present disclosure.

The present disclosure provides a kit for assembling a trajectory array guide system. In some embodiments, the kit includes: a base and an array guide which can be connected to form a lockable ball-socket pivoting mechanism, wherein the base is configured for attachment to the skull of a subject, and wherein the array guide is defined by a series of lumens or is defined by a bore configured to hold a separate guide unit defined by a series of lumens; an imaging unit configured for engagement with the array guide and configured to hold and direct imaging fluid along axes which are co-axial with the lumens for the purpose of defining a series of trajectories; and an elongated handle having sufficient length for connection to an image-guided stereotaxic navigation system, wherein the handle is configured for attachment to either the array guide or the imaging unit.

In some embodiments, the kit further comprises instructions for assembly of the array guide system.

In some embodiments, the kit further comprises a container of imaging reagent.

In some embodiments, the kit is for assembly of a trajectory array guide system of the present disclosure. In some embodiments, the trajectory array guide system includes a guide unit for insertion into the bore of the array guide. In some embodiments, the kit includes a plurality of guide units configured for guiding elongated tools of different diameters. In some embodiments, the elongated tools include a catheter.

In some embodiments of the kit, all components of the trajectory array guide system are contained in one or more sterilized packages.

The present disclosure provides trajectory array guide system which can function to provide or assist with the stereotactic guidance, placement and fixation of surgical instruments or devices during the planning and operation of neurological procedures performed in conjunction with preoperative and perioperative MR imaging. In some embodiments, the procedures can include laser coagulation, biopsies, catheter placement, or electrode placement procedures.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1A is an illustration of installment of one embodiment of a trajectory array guide system 10 on the skull of an individual for the purpose of showing one orientation of this system during a mode of operation.

FIG. 1B is a magnified view of the trajectory array guide system 10 of FIG. 1A.

FIG. 2 is an exploded view of an embodiment of a trajectory array guide system 11 which illustrates placement of an imaging unit 60.

FIG. 3A is a side view of one embodiment of a ball array guide 120 of the trajectory array guide system 11.

FIG. 3B is a cross-sectional view of the ball array guide 120 of FIG. 3A taken along line 3B-3B of FIG. 3A.

FIG. 4A is a top view of one embodiment of a base plate 150 of the trajectory array guide system 11.

FIG. 4B is a cross-sectional view of the base plate 150 of FIG. 4A taken along line 4B-4B of FIG. 4A.

FIG. 5A is a side view of an imaging unit 60 designed for use in one mode of operation of the trajectory array guide system 11.

FIG. 5B is a cross-sectional view of the imaging unit 60 of FIG. 3A taken parallel to line 5B-5B of FIG. 5A.

FIG. 5C is an arbitrary longitudinal cross-section of the imaging unit 60 with the cap 64 removed.

FIG. 6A is a side view of the base plate 150 and the ball array guide 120 with the base plate 150 shown in arbitrary cross section to illustrate a socket 153 of the base plate 150.

FIG. 6B is a side view of the base plate 150 and the ball array guide 120 with a locking nut 130 in place and indicating pivotable movement of the ball array guide 120 within the base plate 150.

FIG. 7A, FIG. 7B and FIG. 7C illustrate a process for obtaining an array of projected trajectories T using an imaging reagent IR in the imaging unit 60 installed in the ball array guide 120.

FIG. 8A, FIG. 8B and FIG. 8C illustrate a process for inserting a catheter 170 into one of the lumens of the ball array guide 120 with maximal depth limited by the location of an insertion stop 171.

FIG. 9A, FIG. 9B and FIG. 9C illustrate a process for using a trajectory T defined by the trajectory array guide system 11 to reach a target TG at a maximum depth DP in the brain of a patient via an entry point E.

FIG. 10A, FIG. 10B and FIG. 10C illustrate a process for connecting the trajectory array guide system 11 at the site of a craniotomy C.

FIG. 11A, FIG. 11B and FIG. 11C illustrate a process for using the trajectory array guide system 11 to generate an array of trajectories T in an effort to define an optimal trajectory OT to a target TG.

FIG. 12A, FIG. 12B and FIG. 12C illustrate a process for insertion of a catheter 170 into the trajectory array guide system 11 to deliver a drug to the target TG.

FIG. 13A is a side elevation view of one embodiment of a trajectory array guide system 12.

FIG. 13B is a cross-sectional view of the trajectory array guide system 12 of FIG. 13A taken along line 13B-13B of FIG. 13A.

FIG. 13C is a bottom view of the trajectory array guide system 12 of FIG. 13A and FIG. 13B.

FIG. 14A is a perspective view of a ball array guide 220 held and locked in place in a base plate 350 with a ring-shaped locking nut 230 having a grip surface 231.

FIG. 14B is a perspective view of a ball array guide 220 held and locked in place in a base plate 350 with a locking nut 330 having cutouts 332a-d.

FIG. 14C is a perspective view of a ball array guide 220 held and locked in place in a base plate 350 with a locking nut 430 having opposing lugs 433a-d.

FIG. 15A is a side elevation view of an embodiment of a trajectory array guide system 17 indicating that the locking nut 230 limits the angle of trajectory of the ball array guide 620.

FIG. 15B is a cross section view of a trajectory array guide system which includes a tilted base plate 450.

FIG. 16 is a perspective view of an embodiment of a base plate 50 whose socket 53 is tilted to provide larger angles of trajectory.

FIG. 17 is a perspective view of base plate 350 whose socket 353 is orthogonal to the plane of the tabs 351a-d.

FIG. 18 is a partial cross-sectional perspective view of a ball 221 of a ball array guide 220 held in a socket 553 of a base plate 550 having tapered outer threads 556 which match inner threads 537 on locking nut 530.

FIG. 19A is a perspective view of an embodiment of a tilted base plate 450 configured for connection to a ring clamp as shown in FIG. 19B.

FIG. 19B is a perspective view of the tilted base plate 450 of FIG. 19A with a ring clamp 80 attached thereto.

FIG. 19C is a perspective view of the tilted base plate 450 of FIG. 19A with a ring clamp 80 attached thereto and showing the rotational freedom of the clamp 80 around the outer groove 458 of base plate 450.

FIG. 19D is a cross-sectional side elevation view of the tilted base plate 450 and ring clamp 80 showing the ball 221 of a ball array guide held in place.

FIG. 20A is a perspective view of a handle 140.

FIG. 20B is a perspective view of an embodiment of the trajectory array guide system 13 showing the handle 140 attached thereto.

FIG. 20C is a side elevation view of the handle 140.

FIG. 20D is a cross-sectional view of the handle 140 of FIG. 20C taken along line 20D-20D.

FIG. 20E is a magnified view of the cross-sectional view of the connector 141 of FIG. 20D.

FIG. 21A is a top perspective view of an embodiment of an imaging unit 360.

FIG. 21B is a bottom perspective view of the imaging unit 360 of FIG. 21A.

FIG. 21C is a top view of the imaging unit 360 of FIG. 21A and FIG. 21B.

FIG. 21D is a bottom view of the imaging unit 360 of FIGS. 21A-21C.

FIG. 21E is a side elevation view of the imaging unit 360 of FIGS. 21A-D.

FIG. 21F is a cross-sectional view of the imaging unit 360 taken along line 21F-21F of FIG. 21E.

FIG. 22 is a perspective view of an embodiment of a trajectory array guide system 14, showing the manner of insertion of tubes 465a-g and 466 into the ball array guide 620.

FIG. 23A is a perspective view of ball array guide 620.

FIG. 23B is a side elevation view of ball array guide 620.

FIG. 23C is atop view of ball array guide 620.

FIG. 23D is a bottom view of ball array guide 620.

FIG. 24 is a cross-sectional perspective view of a portion of an embodiment of the trajectory array guide system 15.

FIG. 25 is an exploded perspective view of an embodiment of the trajectory array guide system 16.

FIG. 26A is a cross-sectional view of an embodiment of a ball array guide 90 which is taken along line 26A-26A of FIG. 26B.

FIG. 26B is a top view of the same embodiment of the ball array guide 90 shown in FIG. 26A.

FIG. 26C is an exploded view indicating connection of a handle 240 to the embodiment of the ball array guide 90 of FIGS. 26A and 26B.

FIG. 26D is a cross-sectional view of embodiment of the ball array guide 90 of FIGS. 26A and 26B with an imaging unit 960 attached to the ball array guide 90. This cross-sectional view is taken along line 26D-26D of FIG. 26E.

FIG. 26E is a top view of the ball array guide 90 of FIG. 26D with imaging unit 960 attached to the ball array guide 90.

FIG. 26F is a cross-sectional view of embodiment of the ball array guide 90 of FIGS. 26A and 26B with a catheter guide unit 920 attached to the ball array guide 90. This cross-sectional view is taken along line 26F-26F of FIG. 26G.

FIG. 26G is a top view of the ball array guide 90 of FIG. 26F with a catheter guide unit 920 attached to the ball array guide 90.

FIG. 26H is a top view of a locking slider 926 for holding a catheter in place in the catheter guide unit 920.

FIG. 27A includes perspective views of embodiments of a catheter guide unit 1020, an imaging unit 1060 and a ball array guide 190 placed in a base plate 450.

FIG. 27B includes bottom perspective views of the same embodiments of the catheter guide unit 1020, imaging unit 1060, ball array guide 190 and base plate 450 of FIG. 27A.

FIG. 27C includes top perspective views of the same embodiments of the catheter guide unit 1020, imaging unit 1060, ball array guide 190 and base plate 450 of FIGS. 27A and 27B.

FIG. 28 is an arbitrary cross-sectional view of an embodiment of a trajectory array guide system 18 including an imaging unit 660 and a handle 340.

FIG. 29 is a perspective view of a partial assembly including imaging unit 660 and attached handle 340.

FIG. 30 is a transparent perspective view of imaging unit 660 showing internal imaging passages 661a, 661d and 661g as well as plenum 669 and passage extension 661a′.

FIG. 31 is a transparent perspective view of the handle 340 showing the internal injection passage 348 and injection port 346.

FIG. 32 is a perspective view of imaging unit 660.

FIG. 33A includes perspective views of an embodiment of a ball array guide 390 having a central bore 392 and an assembly of ball array guide 390 with imaging unit 660.

FIG. 33B includes top perspective views of ball array guide 390 and the assembly of ball array guide 390 with imaging unit 660.

FIG. 34 is a perspective view of an embodiment of a catheter guide unit 720 which has an index lobe 766.

FIG. 35A includes a perspective view of an embodiment of a ball array guide 490 having a central bore 492 and an index lobe receiver 494 and a perspective view of an assembly of ball array guide 490 with catheter guide unit 720.

FIG. 35B includes top perspective views of ball array guide 490 and the assembly of the ball array guide 490 with catheter guide unit 720.

FIG. 36A is a cross-sectional view of an embodiment of a ball array guide 590 with an imaging unit 1160 attached to the ball array guide 590. This cross-sectional view is taken along line 36A-36A of FIG. 36B.

FIG. 36B is a top view of the ball array guide 590 of FIG. 36A with an imaging unit 1160 attached to the ball array guide 590.

FIG. 36C is a cross-sectional view of an embodiment of a ball array guide 590 with a catheter guide unit 1120 attached to the ball array guide 590. This cross-sectional view is taken along line 36C-36C of FIG. 36D.

FIG. 36D is a top view of the ball array guide 590 of FIG. 36A with an imaging unit 1160 attached to the ball array guide 590.

FIG. 36E is a top view of a locking slider 1126 for holding a catheter in place in the catheter guide unit 1120

FIG. 37A is a generalized top view of ball array guide 590 with either imaging unit 960 (straight array) or 1160 (slanted array) attached thereto. This illustration includes clock position markings for the purpose of identifying array locations produced by locking the lock tab 969 or 1169 of imaging unit 960 or 1160, respectively, at each of the different clock positions.

FIG. 37B is an illustration indicating the increased array footprint area provided when imaging unit 1160 is placed at the eight different clock positions. Imaging unit 960 (straight array) provides the same array regardless of its clock position connection to the ball array guide 590.

FIG. 38A is a perspective view of an embodiment of the handle 440.

FIG. 38B is a perspective view of a trajectory array guide system 19 which includes handle 440.

FIG. 38C is an exploded perspective view of trajectory array guide system 19.

FIG. 38D is a top perspective view of the trajectory array guide system 19 without the handle 440 to indicate penetration of set-screws 323a-c into the lumens 325a-g of the ball array guide 320.

FIG. 39 is a perspective view of a trajectory array guide system engaged with an image guided surgery system 1200.

FIG. 40A is a perspective view of an image guided surgery system 1210 clamped onto a handle 440 of a trajectory array guide system.

FIG. 40B is a perspective view of an image guided surgery system 1210 clamped onto a ball array guide 320 of a trajectory array guide system.

DETAILED DESCRIPTION

The present disclosure describes embodiments of a trajectory array guide system which is configured to address a number of shortcomings of known trajectory array guide systems. For example, many such trajectory array guide systems currently in use or under active investigation for use in clinical settings tend to be large, cumbersome and have many separate parts which may be expensive to manufacture and which are prone to damage. Such systems tend to have complicated mechanisms for altering and locking the trajectory paths and as such, tend to require more time to make adjustments than is desirable. In some instances, a contributing factor is that trajectory array guide systems are used while a patient is placed in an MRI system outside of an operating room. This situation increases risk of infection and it is thus desirable to complete the surgical procedure as quickly as possible to minimize patient transportation. It is desirable to have the capability to complete the mounting of the trajectory array guide system and establish an optimal locked trajectory within less than one hour.

The present presents embodiments of a trajectory array guide system as well as methods and kits to address these and other disadvantages of presently known systems.

Definitions

As used herein, the term “array guide” refers to a component used to create a series of images of trajectories for insertion of an elongated tool into the brain of a subject and for guiding a path for the elongated tool. The array guide can be adjustable to adjust the angles of the trajectories. The array guide may have an array of lumens formed in its body or alternatively be provided with a wide bore configured for insertion of one or more separate units for creating the trajectories for imaging and guiding of the elongated tool.

As used herein, the term “ball array guide” is an array guide having a ball formed at one end for the purpose of creating a pivoting ball and socket joint for adjustment of the angles of the trajectories.

As used herein, the terms “cannula” and “catheter” are considered synonymous, each referring to a tube constructed for insertion into the body for surgical treatment or for delivers of an external substance or extraction of an internal substance.

As used herein, the term “imaging fluid” refers to a fluid having properties for providing contrast images under a mode of analysis such as magnetic resonance imaging, for example. This term is synonymous with the term “MRI contrast agent.” The most commonly used imaging fluids in magnetic resonance imaging include gadolinium-based compounds.

As used herein, the term “imaging unit” refers to a component intended for use with an array guide for the purpose of directing imaging fluid to generate images representing an array of trajectories.

As used herein, the term “image-guided stereotaxic navigation” indicates that images generated by an imaging technology such as magnetic resonance imaging, for example, are used to guide stereotaxic navigation.

As used herein, the term “lumen” refers to an opening or cavity within a body of a system component. More specifically, this term is used to identify channels of an array in an array guide which are provided for guiding the insertion of an elongated tool.

As used herein, the term “passage,” like the term “lumen” above refers to an opening or cavity within a body if a system component. More specifically, this term is used to identify channels of an array in an array guide which are provided to deliver imaging fluid to provide trajectory images.

As used herein, the term “plenum” refers to an open space within an otherwise solid body.

As used herein, the term “stereotaxic navigation” refers to provision of three-dimensional navigation within a surgical site using a three-dimensional coordinate system to locate targets within the body and to perform an action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery or any other surgical procedure.

As used herein, the term “trajectory” refers to a potential pathway. More specifically herein, the term is used to identify potential pathways for insertion of a catheter or cannula into the brain.

Overview of One Embodiment of a Ball Trajectory Array Guide System

The present description presents a ball trajectory array guide system with reference to FIGS. 1A to 8C. A number of alternative embodiments are introduced during the course of this description which may be substituted in various compatible combinations according to the knowledge of persons having ordinary skill in the art to arrive at different embodiments of the present invention.

FIG. 1A illustrates a trajectory array guide system 10 fixed to the skull of a subject for the purpose of showing a one orientation of the system during operation. This placement of the system 10 is shown by way of example only. The placement of the system 10 on the skull will vary according to a number of different factors such as access and avoidance of peripheral equipment as well as the desired trajectory of a surgical tool such as a catheter.

A magnified perspective view of the trajectory array guide system 10 is shown in FIG. 1B. In some cases, the head of the subject can be inside the bore of an MRI system (not shown). In some cases where a standard stereotaxic navigation system is not used to provide initial alignment, the head of the subject may be inside the bore of an MRI system for the entire procedure. The system 10 includes a base plate 50 which has four attachment tabs 51a-d with only three (51a-c) of the four attachment tabs 51a-d visible in this perspective view and with the fourth attachment tab 51d hidden from view in this perspective. Each of the four attachment tabs 51a-d has a corresponding opening 52a-52d for insertion of a fastener, typically a bone screw, for fixing the location of the base plate 50 to the skull. The base plate should be located such that an opening made in the skull will be within the central bore of the base plate.

The base plate 50 can include a hollow cup-shaped interior (not shown) acting as a socket to receive the ball 21 of the ball array guide 20. The socket may be designed to provide resistance to the ball such that the array will only move under an externally applied force. One of the advantages of using a ball and socket arrangement is that the socket holds the array in an unlocked state and requires intentional force to adjust the trajectory.

The interior of the ball array guide 20 can include a series of parallel channels or lumens (not shown) which are parallel to the main axis of the ball array guide 20. These parallel channels or lumens can establish an array of parallel trajectories for an elongated surgical instrument, such as a catheter, to enter the brain on a selected trajectory and to reach a desired target location within the brain for delivery of a drug.

The ball-and-socket arrangement allows pivotable movement of the stem 22 of the ball array guide 20. A locking nut 330 with inner threads is provided in this embodiment to be threaded and tightened against outer threads of the base plate 50. Engagement of the locking nut 330 with the out threads of the base plate 50 can compress the socket and prevent pivoting motion of the ball array guide 20 when the desired orientation of the stem is attained.

Also seen in FIG. 1B is a handle 40 with a connector 41 configured for secure attachment to the outward extending end of the ball array guide 20 or to an imaging unit. The connector 41 is joined to an arm 42 which provides an extension of the ball array guide 20 for the purpose of connecting to an image guided stereotactic navigation system. This arrangement allows for manipulation of the position of the ball array guide 20 while viewing a computer monitor with magnetic resonance images of the brain for the purpose of adjusting projected trajectories for catheter placement. Examples of stereotactic navigation systems include: the Varioguide System which is manufactured by BrainLab. AG of Munich; and the Curve Image Guided Surgery system which is manufactured by BrainLab, AG of Munich.

FIG. 2 shows an exploded illustration of an embodiment of the trajectory array guide system 11. The ball 121 of the ball array guide 120 is placed inside the socket 153 of the base plate 150. Base plate 150 is shown as an arbitrary cross section for visualization of the shape of the socket 153 (seen in FIG. 4B) formed by an interior sidewall of the bore of the top portion of the base plate 150. The base plate 150 of this embodiment includes a socket axis essentially orthogonal to the plane containing the upper surfaces of the tabs (151a and 151c seen in FIG. 4B). In contrast to the orthogonal socket axis of the base plate 150 in FIG. 2, the socket axis of the base plate 50 in FIGS. 1A and 1B is tilted away from orthogonality i.e. is non-orthogonal.

The locking nut 130 is passed over the ball array guide 120 and fixed to the upper portion of the outer sidewall of the base plate 150 to lock the orientation of the ball array guide 120. Before or after this step, the imaging unit 60 may be connected to or engaged with the ball array guide 120. The lower portion of the imaging unit 60 has a series of tubes generally labelled in FIG. 2 as 65. While only four tubes are visible in FIG. 2, this embodiment has eight tubes with seven long tubes 65a-g and one short tube 66 (shown in FIGS. 5A-C). The seven long tubes 65a-g fit inside seven corresponding cavities or lumens (shown in FIG. 3B) in the stem 122 of the ball array guide 120 and the remaining upper portion of the imaging unit 60 remains above the top of the stem 122. In some embodiments, these tubes 65a-g and 66 are formed of a thermoplastic polymer such as polyether ether ketone (PEEK) or another polymer having similar properties. The imaging unit 60 can be locked to the ball array guide 120 by three equi-spaced set screws with only one set screw 123a shown in FIG. 2 (the remaining set screws 123b and 123c are seen in the top view of FIG. 3B).

In certain modes of operation, the trajectory array guide system 11 uses the imaging unit 60, In certain modes of operation, the trajectory array guide system 11 does not use the imaging unit 60. In certain modes of operation, both modes (with and without imaging unit 60) will be employed at different points during the procedure.

The connector 41 of the handle 40 is placed over the top of the inserted imaging unit 60 (or without the unit 60 in place) and fixed to the top portion of the ball array guide 120 by threading or another connection mechanism.

FIG. 3A is a similar view of the ball array guide 120 of FIG. 2. In FIG. 3A, a second set-screw 123b is present. The ball array guide 120 also includes an outer groove 124 formed in the stem 122 of the ball array guide 120. FIG. 3B is a cross section of the stem 122 of the ball array guide 120 taken along line 3B-3B of FIG. 3A. It is seen that the stem has seven lumens 125a-g formed therein. The outer groove 124 is also visible in FIG. 3B as well as the third set-screw 123c. The set screws 123a-c can penetrate the body of the ball array guide 120 to enter the spaces of lumens 125b, 125d and 125f, respectively. When corresponding tubes 65 of the imaging unit 60 are inserted into these lumens, 125b, 125d and 125f, the set-screws 123a-c can be tightened against the outer sidewalls of the tubes 65 to fix the imaging unit 60 in place on the ball array guide 120.

FIG. 4A is a top view of the base plate 150 showing the socket 153, the tabs 151a-d and holes 152a-d, and the central bore 154. FIG. 4B, which is similar to the view of the base plate 150 in FIG. 2, is a cross section taken along line 4B-4B of FIG. 4A,

FIG. 5A is a side view of the imaging unit 60. FIG. 5B is a cross-sectional view of the imaging unit 60 taken along line 5B-5B of FIG. 5A. The imaging unit 60 has a reservoir 63 for filling a series of tubes 65a-g and 66 with an imaging fluid, such as a gadolinium-based MRI contrast reagent for example. In some embodiments, the imaging unit includes tubes constructed of a radiopaque material which is visible under MRI and computerized tomography. When the imaging fluid is added to the reservoir 63, it enters all of the tubes 65a-g and 66. The imaging fluid within the tubes 65a-g can then provide a means of imaging the trajectory paths defined by the axes of the tubes. Tube 66 (the shorter tube) is an indexing tube which is provided outside of the hexagonal symmetry of the other tubes 65a-g for the purpose of easily identifying the seven tubes used for imaging the trajectories. In this side view of FIG. 5A, only tubes 65c, 65d, 65g and 66 are visible with the remaining tubes 65a, 65b, 65e and 65f being hidden from view. These hidden tubes 65a, 65b, 65e and 65f are seen in the cross-sectional view of FIG. 5B which is taken along line 5B-5B of FIG. 5A. Also seen in FIG. 5A is a cap 64 to seal and cover the top of the reservoir 63. FIG. 5C is an arbitrary longitudinal cross-sectional view of the imaging unit 60 with the cap 64 removed.

FIG. 6A is a side view illustration of the ball array guide 120 installed in the socket 153 of the base plate 150 prior to installment of the locking nut 130. FIG. 6B shows the same arrangement after installation of the locking nut 130 and additionally shows pivoting rotation of the ball array guide 120 and a projected trajectory T corresponding to one of the lumens 125a-g (not seen in FIG. 6A) in the body of the ball array guide 120.

FIG. 7 shows a system and process for defining a series of projected trajectories using the imaging unit 60 in order to identify an appropriate trajectory for insertion of a catheter to reach a target location in the brain (not shown). The tubes 65a-g and index tube 66 of the imaging unit 60 are filled with an imaging reagent IR which subsequently fills the upper reservoir 63. The imaging unit is inserted into the ball array guide 120 with the tubes 65a-g (see FIG. 5B) entering corresponding lumens 125a-g (see FIG. 3B). The index tube 66 slides along the outer groove 124 (see FIGS. 3A and 3B). The imaging unit 60 is fully inserted into the ball array guide 120. The tubes 65a-g and 66 are filled with imaging reagent IR (such as a gadolinium-based contrast reagent which provides a bright white image under MRI) and are used to define a series of projected trajectories T into the brain while the head of the subject is placed in an MRI system. One of the trajectories T is selected for insertion of a catheter (not shown). The image of the bottom of the reservoir 63 serves as an index point or datum to define the insertion depth of the catheter. There is gap of known dimensions between the bottom of the reservoir 63 and the top of the ball array guide 120 due to the thickness of the bottom of the imaging unit 60. The index tube 66 is shorter than the other tubes 65a-g. The image of the index tube 66 (provided by the imaging reagent IR) is used as a reference to correctly identify the individual trajectories T under MRI (which would otherwise be impossible due to the symmetry of the hexagonal pattern of tubes 65a-g). The imaging unit 60 is then removed from the ball array guide 120.

FIG. 8A-8C illustrates a system and process for insertion of a catheter 170 into the ball array guide 120 after a trajectory is selected and the imaging unit 60 is removed. The free end of the ball array guide 120 serves as the datum D for the depth of insertion of the catheter 170. The structure of the catheter 170 is shown in FIG. 8B. The maximum depth of insertion of the catheter 170 is defined by the location of the insertion stop 171 on the catheter 170. FIG. 8C shows two illustrations of the catheter 170 being partially inserted (left) and fully inserted (right) into the optimal target trajectory as identified by analysis of the trajectory images. In some embodiments, to make the system compatible with 14 and 16-gauge catheters, two separate trajectory arrays with lumens for 14 and 16-gauge catheters can be provided. This will also require two separate imaging units with 14 and 16-gauge tubes, respectively. Alternatively reducing tubes can be used with a 14-gauge array to accommodate small diameter instruments.

As noted above, MRI images of the patient's brain are obtained to guide the overall procedure. Surgical planning is performed by the surgeon using preferred planning software to pre-plan entry sites and catheter trajectories to the target locations in the brain. In addition, MRI systems typically include software for 3D reconstruction of the images and further image analysis including dimensional analysis to obtain locations, dimensions, planes, and trajectories for catheter insertion to the target location. Standard image-guided stereotactic platforms available to neurosurgeons in combination with software provided by the manufacturer are used to guide the entire procedure. From the analysis of the MI scans the following dimensions and landmarks are identified: target location(s): entry point on the skull; a preferred trajectory from the entry point to the target location(s); and insertion depth, which is defined as the distance from the entry point to the target location(s).

The entry point and trajectory are selected to avoid potential damage to blood vessels and brain sections by the catheter. In some cases, the trajectory is chosen to allow for multiple injections into the target along the pathway of the catheter as illustrated in FIG. 9A-9C.

In some embodiments, components of a trajectory array guide system are sterilized. Suitable sterilization methods for the components include high heat, steam, ethylene oxide or radiation such as gamma sterilization. In some embodiments, components of a trajectory array guide system are made of medical grade materials, including medical grade plastics, medical grade polymers, and medical grade metals. Specific examples of medical grade materials include, but are not limited to: medical grade polyether ether ketone (PEEK); medical grade silicon, medical grade steel (such as medical grade stainless steel); and medical grade aluminum.

Overview of Operation of One Embodiment of the Trajectory Array Guide System

The present disclosure provides a system and method for delivering n elongated tool to a target location in the brain of a subject which uses a trajectory array guide system of the present disclosure. An example describing the operation of a trajectory array guide system 11 is presented with reference to components illustrated in FIGS. 2 to 12C.

A patient receives general anesthesia in preparation for the procedure. A head stabilization system is used to avoid head motion during the procedure. The placement of the trajectory array guide system 11 is performed in a sterile environment in a surgical operating room or a hybrid operating room with MRI capabilities. The head is shaven and the desired entry point is marked. The incision site is draped and a skin flap is created with a scalpel to expose the skull for placement of the trajectory array guide system 11. A craniotomy C can be made either at this time (see FIG. 10A) or after placement of the base plate 150. The ball array guide 120 is loosely mounted onto the base plate 150 and the handle 40 is connected to the trajectory array guide system 11. The imaging unit 60 filled with gadolinium imaging reagent IR is inserted into the ball array guide 120. The assembled trajectory array guide system 11 (see FIG. 2) is then connected via the handle 40 to a guiding system such as the VarioGuide navigation system to correctly orient the trajectory array to the pre-determined trajectory (FIG. 10B).

Once a suitable orientation of the trajectory array guide system 11 is established, it is lowered to the surface of the skull and the base plate 150 is secured onto the skull by securing up to four bone screws into the four holes 152a-d of the tabs 151a-d of the base plate 150. If a craniotomy was not previously made, the upper portion of the trajectory array guide system 11 including the handle 40 is removed from the socket of the base plate 150 to allow access through the base plate 150 to make a burr hole in the skull according to known surgical procedures. The trajectory array guide system 11 is then reattached to the base plate 150 with proper alignment confirmed by the stereotactic navigation system. The locking nut 130 is then tightened to preserve the orientation and prevent any further movement between the system components. The handle 40 is disconnected from the stereotactic navigation system and removed, as shown in FIG. 10C. In case of a hybrid surgical suite, the patient is ready for MR imaging. In case of a separate imaging suite, the incision site and trajectory array guide system 11 are covered with a sterile drape and the patient is transported to the imaging suite.

As an alternative workflow, it is envisioned that the entire procedure could be performed within an MRI scanner without use of an alternative imaging system to align the trajectory array guide system 11. Some alternative navigation system, or MRI sequences, will be needed to identify the entry point for attachment of the base plate but alignment of the trajectory array guide system 11 would be performed entirely as described below for refinement of the trajectory.

MRI scans of the patient's brain are performed to confirm that the correct entry point and trajectory have been established. FIGS. 11A-11C illustrate the MR imaging and analysis procedure. An illustration of a magnetic resonance image of the brain of the patient and the trajectory array guide system 11 mounted on the skull. The imaging reagent IR contained in the reservoir 63 and tubes 65a-g and 66 of the imaging unit 60 provides bright white images on the MRI scan (see FIG. 11A). 3D reconstruction and subsequent image analysis on the MRI scanner console is used to determine the sagittal and axial plans of each trajectory and to project the trajectories T originating from the tubes 65a-g and 66 of the imaging unit 60 into the brain toward the target location TG (see FIG. 11B). The optimal trajectory OT is selected from the array of possible trajectories T (see FIG. 11C). While it is helpful to use the central lumen 125g for initial alignment, the surrounding lumens 125a-f provide alternative parallel trajectories T which can be employed if required. The image of the index tube 66 serves as a directional reference to identify each individual lumen in the array of lumens 125a-g in the ball array guide 120. If none of the trajectories T is deemed suitable, the direction of the trajectories T can be adjusted by loosening the anchor lock nut 130 to allow pivoting movement of the ball array guide to provide an improved series of trajectories T. The ball array guide 120 should not move without intentional force when the lock nut 130 is loosened. Then the ball array guide 120 is tightened with the lock nut 130 to secure the new orientation. The MR imaging and analysis procedure is then repeated.

When the optimal trajectory is confirmed, the imaging unit 60 is removed from the ball array guide 120. From the MRI images the initial and maximum depth of insertion of the catheter 170 is measured using the base of the reservoir of the imaging unit 60 as the datum (a correction equal to the thickness of the imaging unit base must be made). A depth insertion-stop 171 is mounted on the drug delivery catheter 170 at a distance from the tip of the catheter 170 equal to the maximum insertion depth as shown in FIG. 12A (see also FIGS. 8A-8C) and a distance equal to the initial depth is marked onto the catheter 170 with a sterile pen. The catheter 170 is carefully inserted through one lumen of the array of lumens 125a-g in the ball array guide 120 to the initial target depth and secured by a lock screw which is configured to penetrate all lumens 125a-g of the ball array guide 120, The correct position of the tip of the catheter 170 is confirmed by MRI and the drug is injected (see FIG. 12B). The catheter 170 is then withdrawn as shown in FIG. 12C. In situations where one or more targets along the optimal trajectory OT can be reached before the insertion stop 171 prevents further insertion, additional boluses of drug may be injected at these targets. Likewise, such targets may receive injections with pausing during the phase of retraction of the catheter 170.

The trajectory array guide system 11 is removed from the skull by removing the bone screws. The wound is closed using standard surgical techniques.

One embodiment of a procedure sequence will now be briefly outlined. This procedure sequence assumes that the entire system 11 may be assembled prior to mounting to the skull of the subject.

First the entire trajectory array guide system 11, including the imaging unit 60 and the handle 40, is assembled. Then a surgical navigation system is connected to the handle 40. The entry location on the skull is identified and a craniotomy C is performed to expose the entry location. Then the base plate 150 is connected to the skull. The handle 40 is removed to add imaging reagent IR to the trajectory array guide system 1ii. MRI scans are then performed to view the projected trajectories T and the optimal trajectory OT is selected. The handle 40 is reattached to facilitate additional manipulation of the optimal trajectory OT, if required. The imaging unit 60 is then removed with confirmation that the selected optimal trajectory OT remains locked in place. The catheter procedure is performed using the optimal trajectory OT and then the system 11 is removed from the subject.

In some embodiments, the screw holes of the base plate can be directly accessed by a screwdriver during the process of assembly and disassembly.

Commonly used magnetic resonance imaging has a spatial resolution of about 1 mm. Therefore, in some embodiments, the trajectories in the array are spaced between about 1 mm to about 3 mm apart; between about 1.5 mm to about 2.5 mm apart; about 2 mm apart; about 2.15 mm apart; about 2.25 mm apart; or about 2.35 mm apart.

Base Plate and Locking Nut Combination

FIGS. 13A-13C show an embodiment of trajectory array guide system 12 in which a locking nut 230 is disposed directly above screw holes in the tabs 251a-d of the base plate 250 once the system 12 is assembled. FIGS. 13A-13C also show the system 12 with an imaging unit 260, a ball array guide 220 including the ball 221, lumens 225a-g and set screws 223a-c, as well as features of the imaging unit 60 including the reservoir 263, tubes 265g and 266, and cap 264.

In certain embodiments, a trajectory array guide system can be assembled prior to mounting onto a skull. In certain embodiments, the trajectory array guide system provides unobstructed access to the screw holes in the base plate to place the bone screws. The images in FIG. 14A to 14C show three alternative embodiments that provide unobstructed access to the screw holes of the tabs. In all three embodiments, the base plate 350 is identical and the screw holes 352a-d of the tabs 351a-d are moved radially outward by 2 mm, thereby increasing the footprint of the base plate by 4 mm (tab 351d with screw hole 352d is not visible in the perspective views of FIGS. 14A-14C). While base plate 350 is illustrated in FIGS. 14A-14C, other base plate embodiments, such as the tilted base plate 50 of FIGS. 1A and 1B, for example may be substituted for base plate 350.

In FIGS. 14A-14C, the locking nut is modified differently in each of the three illustrated embodiments to provide convenient access to the screw holes 352a-d of the tabs 351a-d.

In FIG. 14A, the locking nut 230 is the same as in FIGS. 13A to 13C and has a grip surface 231 to facilitate application of tightening and loosening force.

In FIG. 14B, the locking nut 330 is modified relative to locking nut 230 to include four cutouts 332a-d to provide additional space for access of a screwdriver to the screw holes 352a-d in the tabs 351a-d of the base plate 350. This embodiment 330 of the locking nut also has a grip surface 331.

In FIG. 14C, the locking nut 430 is provided with four equi-spaced lugs 433a-d to facilitate application of tightening/loosening leverage against the locking nut 430.

Tilted Base Plate

In certain procedures, it is favorable to enter the skull at angles of up to about 45 degrees from the central orthogonal axis of a base plate. FIG. 15A illustrates a trajectory array guide system 17 which includes a ball array guide 620 and imaging unit 460. The trajectory array guide system 17 also includes a flat base plate 350 with an orthogonally-directed socket and a locking nut 230. The angular range of the trajectory array guide system 17 shown in FIG. 15A is limited by the flat base plate 350 and the locking nut 230, and is only about 30 degrees from the centerline.

FIG. 15B illustrates a trajectory array guide system which includes a ball array guide 220 and a base plate 450 which includes a socket 453. The axis of the socket 453 relative to the base plate 450 is tilted by about 20 degrees with a with a ring clamp 80. This tilt provides the capability of expanding the range of trajectory angles up to about 45 degrees from normal centerline.

FIG. 16 shows an embodiment of a base plate 50. The base plate 50 is tilted and includes the four tabs 51a-d with screw holes 52a-d (screw hole 52d is hidden from view in this perspective). The outer sidewall of the socket 53 is provided with outer threads 54 for coupling to inner threads of one or more different embodiments of a locking nut (not shown in FIG. 16). Also seen in FIG. 16 are four compression slots 55a-d which are provided to provide the socket with additional flexure to improve tightening of the locking nut against the outer sidewall of the socket 53. The slots 55a-d make the circumference of the socket 53 less rigid and therefore more easily compressed against the ball of the ball array guide. The bottom of the center bore of the base plate 50 is provided with a chamfer (not shown) to avoid interference of the catheter with the inner rim of the base plate at significantly large angles relative to the axis which is orthogonal to the plane formed by the bottom of the plate.

For comparison. FIG. 17 shows an embodiment of a base plate 350. This embodiment 350 has a socket 353 with an axis which is orthogonal to the plane containing the four tabs 351a-d as well as outer threads 354 and three compression slots 355a-c. As noted above with reference to FIGS. 15A-15B, this embodiment 350 of the base plate is limited to trajectory angles at or less than 31.2 degrees.

In some embodiments, a base plate of the present disclosure can have a bore diameter of between about 20 mm to about 50 mm, between about 30 mm to about 40 mm, or a bore diameter of about 35 mm.

In some embodiments, a kit of the present disclosure includes a trajectory array guide system which includes only a tilted base plate. In some embodiments, the trajectory array guide system includes only a flat base plate.

Locking Nut Modifications and Alternatives

FIGS. 14A to 14C show the ball 221 of the ball array guide 220 locked into the socket 353 of the base plate 350 by different embodiments of locking nuts 230, 330 and 430 which allow access of an attachment tool such as a screwdriver to the holes of the attachment tabs 351a-d. In each of these three embodiments 230, 330 and 430, locking is achieved by the downward force of the lock nut onto the ball 221. Friction forces created between the rotating lock nut and the ball during the final stages of tightening can cause the ball to rotate and lose its orientation. In some embodiments, the ball array guide 220 is stabilized as the lock nut is tightened.

In some embodiments, a ball locking mechanisms can use radial inward compression of the base plate socket to lock the ball of the ball array guide into the socket. In some embodiments, the inward compression of the socket does not create any motion between the parts that could misalign the ball array guide.

FIG. 18 illustrates an arbitrary cross-sectional view of one embodiment of a ball locking mechanisms which uses radial inward compression of the base plate socket to lock the ball of the ball array guide into the socket. FIG. 18 shows a tilted base plate 550 provided with upwardly tapered outer threads 556 for coupling to the lock nut 530 which has complementary tapered inner threads 537 (i.e. the circumference of the outer threads 556 of the base plate 550 become wider from the top towards the bottom of the outer sidewall of the socket 553). This tightening and locking mechanism provides the required functional effect of compression of the socket 553 without causing significant friction with the ball 221 or creating create motion between the parts that could misalign the ball array guide. In one variation of this embodiment (not shown), the outer rim of the socket is provided with an upwardly projecting ridge and the lower rim of the circumference of the nut is partially cut away. In combination, these features ensure that the nut does not make contact with the ball.

FIGS. 19A-19D illustrate a ring clamp mechanism for providing external compression against the outer sidewall of a socket. FIGS. 19A-D show base plate 450 for cooperation with the ring clamp 80, Base plate 450 is provided with an outer groove 458 which can receive an inner circumferential ridge 81 of a ring clamp 80, as shown in FIG. 19D. A tension screw 82 (See FIGS. 19C-19D) is used to tighten or loosen the ring clamp 80. Adding more tension will compress the ring clamp 80 and produce radial inward compression on the outer sidewall of the socket 453 to lock the ball 221 in place in the socket 453. FIG. 19C illustrates an embodiment where the ring clamp 80 has complete rotational freedom around the outer groove 458 of base plate 450 when the tension screw 82 is not tight. The rotational freedom of the ring clamp 80 allows the tension screw 82 to be positioned and tightened at any rotational position necessary for the operation of the trajectory array guide system.

In some embodiments, the ring clamp has a low profile which increases the maximum deflection angles of the trajectory array from the centerline. In some embodiments, the ring clamp has a low profile which allows direct access to the screw holes without the need to extend the footprint of the base plate.

Embodiments of the present disclosure describe trajectory array guide systems which generally include a ball unit configured to fit into a socket of a base plate. In some embodiments, a trajectory array guide system can be reconfigured to include a base plate having a ball unit and an array guide having a socket configured to receive the ball unit of the base plate.

Handle

In some embodiments, the orientation of the ball array guide and corresponding series of parallel trajectories is facilitated by a commercially available MRI or CT image-guided navigation system. In some embodiments, a handle can be used to connect the ball array guide with a navigation system. The handle can be engaged directly with the ball array guide. The handle can also be engaged with an imaging unit connected to the ball array guide. FIG. 20A shows one embodiment of a handle 140. FIG. 20B shows the same handle 140 attached to an imaging unit 360 of an assembled trajectory array guide system 13 which includes a longer embodiment of the ball array guide 620. In this embodiment, the connector 141 of the handle 140 is configured to be placed over the body of the imaging unit 360. A set screw 144 is placed in the side opening 143 of the connector 141 to lock the handle 140 to the imaging unit 360. The arm 142 of this embodiment of the handle 140 is roughly twice the length of the ball array guide 620. The length of the arm may vary according to the needs of the particular situation. Combinations of handles which have longer and shorter arms may be provided in kits for assembling various embodiments of a trajectory array guide system.

FIGS. 20C to 20E illustrate an embodiment of the handle 140. FIG. 20C is a side elevation view of the handle 140 and FIG. 20D is a cross-section taken along line 20D-20D of FIG. 20C. FIG. 20E is a magnified view of the connector 141 of the handle showing the opening 143 for insertion of the set screw 144 (see FIG. 20B) and an air hole 145 located near the lower end of the connector 141 in this view. The purpose of the air hole 145 is to provide a passage to allow air to escape when the connector 141 is placed over the outer sidewall of an imaging unit with a tight seal.

In some embodiments, the handle has a total length of between about 12 to about 18 cm. In some embodiments, the arm portion of the handle has a diameter of between about 6 to about 10 mm.

In some embodiments, the handle is similar to the embodiment of FIGS. 20C to 20D with the exception that the arm is hollow to allow insertion of a pointer probe which can be locked in place with a set screw through the opening in the connector.

Imaging Unit

An imaging unit can be configured for connection to or engagement with a ball array guide and a handle. In some embodiments where the ball array guide uses an offset index tube (such as tube 66 of FIG. 5A for example), the imaging unit can have an index tube arranged co-axially with the outer index groove of the ball array guide (see for example, FIG. 22), Shown in FIGS. 21A and 21B are two perspective views of an embodiment of an imaging unit 360. In FIGS. 21A-21F, the imaging unit is shown without tubes being connected. The imaging unit 360 can be connected to eight tubes to provide axes for imaging trajectories and indexing.

FIG. 21A is a top perspective view and FIG. 21B is a bottom perspective view of the imaging unit 360. FIG. 21C is a top view and FIG. 21D is a bottom view, FIG. 21E is a side elevation view and FIG. 21F is a cross sectional view taken along line 21F-21F of FIG. 21E. This imaging unit 360 is constructed to fit over the top end of a ball array guide. In the top perspective view of FIG. 21A, the top openings of all eight of the passages 361a-g and 362 (an indexing passage) are visible, as well as the reservoir 363 and a groove 368 formed in the outer sidewall of the imaging unit 360. This groove 368 is provided to receive a locking set-screw 144 extending through the connector 141 of the handle 140. FIG. 21B is a bottom perspective view of the same embodiment of the imaging unit 360, In this perspective view, the index passage 362 is not visible. For further clarity, top and bottom views of the same embodiment of the imaging guide 360 are shown in FIGS. 21C and 21D, respectively. Each of these views includes alignment lines to indicate the spatial relationships among the passages 361a-g and 362. Passages 361a-f are equi-spaced and arranged in a symmetrical hexagonal shape with passage 361g in the center and index passage 262 aligned with the line formed between passages 361c and 361d as well as the line formed between passages 361e and 361f. It is clearly seen in the cross-sectional view of FIG. 21F that the imaging unit 360 has an upper reservoir 363 for holding a volume of imaging reagent and a lower gap 367 below the intermediate solid section within which the passages 361a-g and 362 are formed. This cross-sectional view has only one passage 361g (the central passage) visible. It is seen that the upper part of passage 361g has a smaller diameter than its lower part. This arrangement is also clearly seen in a comparison of the top view of FIG. 21C with the bottom view of FIG. 21D. The larger bottom diameter is for the purpose of insertion of separate trajectory imaging tubes (not shown). During assembly of a complete imaging unit 360, the tubes are inserted and bonded into the passages 361a-g and 362 via the bottom of the imaging unit. The upper reduced diameter of each passage acts as a stop to prevent passage of the tubes into the reservoir 363.

FIG. 22 illustrates an embodiment of a trajectory array guide system 14. An embodiment of an imaging unit 460 is inserted into a longer embodiment of a ball array guide 620 (shown in more detail in FIGS. 15A, 15B, 20B and 23A-D). The imaging tubes 465a-g and 466 being arranged co-axially with the lumens 625a-g (seen at the bottom of the ball 621 of the ball array guide 620) and outer groove 624 formed in the outer sidewall of the stem 622 of the ball array guide 620. The tubes 465a-g and 466 of the imaging unit 460 will thus enter the corresponding lumens 625a-g and outer groove 624 of the ball array guide 620. The trajectory array guide system 14 includes locking nut 730 and base plate 350.

In some embodiments, the process of using the imaging unit 360 to produce images for calculation of trajectories to an identified target in the brain will include insertion of tubes 465a-g and 466 into each of the passages 361a-g and 362 of the imaging unit 360, followed by attachment of the imaging unit 360 to the upper end of the ball array guide 620 with the tubes 465a-g and 466 extending into the corresponding lumens 625a-g and outer groove 624.

Ball Array Guide and Lumens

In some embodiments, the ball array guide provides for the placement and accuracy of a catheter. The catheter is passed through a selected lumen of the ball array guide to reach a target. To allow for smooth insertion, the array guide can provide sufficient clearance between the outer diameter of the catheter and the inner diameter of each lumen of the trajectory array. The accuracy of catheter placement can be increased by increasing the length of the lumens. In some embodiments, a ball array guide and corresponding lumens have a length between about 30 mm to about 60 mm, between about 40 mm to about 50 mm, or a length of about 45 mm. In some embodiments, a ball array guide includes two parts each having a defined length that are bonded together. Such a combination of parts could be machined, 3D-printed parts, or molded parts.

FIGS. 23A-D illustrates an embodiment of a ball array guide 620. FIG. 23A is a perspective view of the ball array guide 620 where the ball 621, stem 622 and lower openings of lumens 625a-g are visible. The outer groove 624 for placement of the index tube is not visible but is to be understood to be present in this embodiment of the ball array guide 620.

The openings of the lumens 625a-g are at a flat bottom part 628 of the ball. Near the top of the stem are three set-screw holes 627a-c for insertion of set screws (not shown) to fix tubes of an imaging unit (not shown) engaged with the ball array guide. FIG. 23B is a side elevation view of the ball array guide 620. FIG. 23C is a top view of the ball array guide 620 and FIG. 23F is a bottom view of the ball array guide 620. The dashed lines in FIGS. 23C and 23D indicate that the lumens 625a-f are arranged symmetrically in a hexagonal shape and lumen 625g is in the center of this hexagonal shape.

Embodiments of a Trajectory Array Guide System

The president disclosure illustrates how compatible components can be assembled in different combinations to produce various embodiments of a trajectory array guide system. FIG. 24 illustrates a cross-sectional perspective view of one embodiment of a trajectory array guide system 15, The system includes a ball array guide 220 which has a short stem 222 and a ball 221 which is compatible with the socket of the tilted base plate 550. The tilted base plate 550 has tapered threads configured to thread to locking nut 530.

Imaging unit 360 is attached to the top of the stem 222, The center passage 361g and the index passage 362 of the imaging unit 360 are aligned with the center lumen 225g and the outer groove 224 of the ball array guide 220 (the tubes are omitted in an effort to preserve clarity). The cap 364 of the imaging unit 360 is engaged with the top of the imaging unit to isolate the reservoir 363. Handle 140 is engaged with the outer circumference of the imaging unit 360 and a set screw (not shown) can be used to lock the connector 141 of the handle 140 via the opening 143 in the sidewall of the connector 141. Arm 142 extends outward from the connector 141,

FIG. 25 is an exploded perspective view of an embodiment of a trajectory array guide system 16 which includes a reducer component 75 which can reduce the diameter of one of the lumens 225a-g of the ball array guide 220. This may be necessary if a smaller gauge catheter is used, as the reducer can reduce significant deviations of the catheter from its desired trajectory. The reducer 75 includes a reducer tube 76 with a diameter smaller than the diameter of the lumens 225a-g. The reducer tube 76 is engaged with a reducer disc 77 which includes a set-screw 78. The set screw 78 allows the depth of an inserted instrument to be locked in place within the reducer tube. The reducer tube 76 can be locked in place using one of the ball array guide set screws 123a-c.

Embodiments of a Trajectory Array Guide System with Separate Imaging Units and Guide Units

In some embodiments, a trajectory array guide system can include an array guide in the form of a wide bore sleeve (instead of a series of lumens). This wide-bore array guide includes a ball joint for connection to a base plate. The bore of the array guide is configured to receive an imaging unit and a matched array catheter guide unit (i.e. the arrangement of imaging unit passages and catheter guide unit lumens are matched such that trajectory images generated by the imaging unit will be co-axial with the lumens in order to ensure that the pathway followed by the catheter matches the selected trajectory). This embodiment of a trajectory array guide system provides a capability to provide independent diameter sizing of the lumens used for imaging (i.e. containing imaging reagent) and the lumens used for guiding the catheter. This embodiment also provides for height alignment of the top of the catheter guide lumens with the bottom of the top imaging chamber. This embodiment can provide more reliable general alignment of components while being less delicate than embodiments using an imaging unit with imaging trajectory tubes. In general terms, the ball portion of the array guide of this embodiment is expected be larger than the ball portion of other embodiments described herein. The use of a ring-clamp as a locking mechanism is particularly amenable for use with trajectory array guide systems having separate imaging array and catheter array units because it allows greater angles of tilting of the array guide.

One embodiment of a trajectory array guide system is shown in FIGS. 26A to 26H. FIG. 26A illustrates a cross-section (taken along line 26A-26A of the top view of FIG. 26B) of a funnel-shaped ball array guide 90 with a ball 91 at the bottom and a tapered internal bore 92 configured to receive matched imaging and catheter guide units. The top of the array guide 90 has a lock tab 93 with a bolt hole 94 for locking a corresponding imaging unit or catheter guide unit to the array guide 90. These features are also illustrated in FIG. 26B which illustrates a top view of the array guide 90.

FIG. 26C shows an arrangement for the connection of a handle 240 to the array guide 90 using a handle adapter 249 which is adaptable for engagement with different surgical navigation systems.

FIG. 26D is a cross-sectional view of one embodiment of an imaging unit 960 inserted into the array guide 90. This cross-sectional view is taken at line 26D-26D of FIG. 26E. The imaging unit 960 has a lock tab 969 which is aligned with lock tab 93 of the array guide 90 for locking the imaging unit 960 in place with a lock bolt 95a. The imaging unit 960 has a reservoir 963 for holding imaging fluid and a series of passages 961a-g and a shorter index passage 962 for imaging a series of trajectories.

FIG. 26F shows a similar arrangement (representing a cross-sectional view taken along line 26F-26F of the top view of FIG. 26G) with a catheter guide unit 920 inserted into the array guide 90. The catheter guide unit 920 has a series of lumens 925a-g and a shorter index lumen 924. Any one of lumens 925a-g may be selected based on a trajectory identified using the imaging unit 960. Passages 961a-g of the imaging unit are matched and aligned with corresponding lumens 925a-g of the catheter guide unit 920. For example, if trajectory images provided by the imaging unit 960 indicate that lumen 961c represents the optimal trajectory to the target, this will be noted and after the imaging unit 960 is removed and the catheter guide unit is inserted, lumen 921c will be the lumen used to guide the catheter to the target. The catheter guide unit 920 also has a lock tab 929 to lock the catheter guide unit 920 in place within the array guide 90. The catheter guide unit 920 also includes a locking slider 926 with openings 928a-g for locking a catheter in place within one of the selected lumens 925a-g. This locking slider 926 is shown by itself in a top view in FIG. 26H.

An example describing the operation of a trajectory array guide system is presented with reference to components illustrated in FIGS. 26A-26H.

The system is assembled with the array guide 90 connected to a base plate, such as base plate 450 for example, and with the imaging unit 960 inserted and locked into the bore 92 of the array guide 90 using the lock bolt 95a. The imaging reagent contained within the passages 961a-g and 962 is used to visualize the series of trajectories towards the target and the optimal trajectory is selected. With the array guide 90 locked in place in the base plate 450, the imaging unit 960 is removed and the catheter guide unit 920 is inserted into the bore 92 of the array guide 90 and locked in place using the lock bolt 95a. The locking slider 926 is placed in the catheter guide unit 920 and held in place using lock bolt 95b to retain the catheter in place in the selected lumen which represents the selected optimal trajectory.

FIGS. 27A-27C illustrate a generally funnel-shaped ball array guide 190 which is provided with a wide bore 192 to receive both a funnel-shaped imaging unit 1060 and a matched catheter guide unit 1020. The ball array guide 190 is shown connected to the socket of base plate 450. The ball array guide has a lock tab 193 for locking to a corresponding lock tab 1069 of the imaging unit 1060 and for locking to a corresponding lock tab 1029 of the catheter guide unit 1020. The lumens 1025a-g and index lumen 1024 as well as the passages 1065a-g and index passage 1066 are visible in FIG. 27C.

Trajectory array guide systems which include a funnel-shaped array guide and corresponding funnel-shaped units can have advantages over other embodiments of the trajectory array guide system. For example, the array of tubes of imaging units can be difficult to insert into corresponding lumens of a ball array guide. There is also a manufacturing challenge in sealing tubes to an imaging unit. There can also a degree of movement between the ball array guide and the tubes which cause a degree of flexure of the system when a handle is connected. In addition, a reducer (see for example reducer 70 in FIG. 25) is required to handle catheters with reduced diameters, whereas the construction of a funnel-shaped catheter guide unit of the present disclosure can be modified to provide units with different sized lumens. Notably, 14-gauge and 16-gauge catheters can require different correction factors for insertion depth. This is particularly important because lower gauge (reduced diameter) imaging unit lumens may provide the best images. The embodiment described in this section addresses these disadvantages, among others.

Trajectory Array Guide System with Alternative Imaging Fluid Injection Path and Handle Connection

FIG. 28 is an arbitrary cross-sectional perspective illustration of one embodiment of a trajectory array guide system 18 which uses separate imaging and catheter guide units in a manner similar to the system described in FIG. 26A to FIG. 27C.

This trajectory array guide system 18 includes base plate 450 with its tilted socket and a ring clamp 80. This base locking combination is used to retain an embodiment of a ball array guide 290 which like the ball array guide 90 of FIG. 26 has a ball 291 configured to be held in the socket of the base plate 450 and a bore 292 for holding imaging and catheter guide units. In FIG. 28, an imaging unit 660 is shown inserted into the bore 292 of the ball array guide 290. This imaging unit 660 has a series of seven passages 661a-g with only passages 661a, 661d and 661g being visible in this perspective view. Lumens 661b-g terminate at an orthogonal passage-connecting plenum 669 which is located at the center of rotation of the ball 191. Passage 661a is extended a short distance downward from the plenum 669 and forms a passage extension 661a′.

In this embodiment, the handle 340 is provided with an injection passage 348 along the axis of the arm 342 through to the connector 341 which fits into a cavity in the upper chamber 663 of the imaging unit 660. The injection passage 348 in the arm 342 of the handle 340 is for injection of imaging fluid via a port (not shown) in the arm 342. The port may be located at any position along the arm 342 of the handle 340 as long as imaging fluid may be effectively injected into the injection passage 348. When continuously injected, the imaging fluid moves down the injection passage 348 and enters the center passage 661g. When the injected imaging fluid reaches the plenum 669, the imaging fluid then disperses in the plenum 669 and fills the remaining passages 661a-f from the bottom upwards. The imaging fluid also fills the lower extension 661a′ of passage 661a. In this manner, all passages 661a-g are appropriately filled with imaging fluid for identification of the array of parallel trajectories. The lower passage extension 661a′ is easily identified and distinguished from the remaining passages under magnetic resonance imaging and serves as an index image for identification of the trajectory images (this would otherwise be impossible due to the symmetrical hexagonal arrangement of the passages 661a-g). This arrangement obviates the need for an eighth passage used as an index passage as in the previous embodiments.

As a result of this arrangement of features, all passages 661a-g and 661a′ can be filled with imaging fluid via a port (such as a Luer taper injection port) in the handle 340 which is conveniently accessible (see for example, FIG. 31). An air hole (not shown) is provided in communication with the flow path of injected fluid in order to allow air displaced by the imaging fluid to vent from the flow path. This arrangement also allows the flow path to be purged with fluid or air for cleaning.

In some embodiments, the connector 341 of the handle 340 slides into the upper chamber 663 of the imaging unit. This provides an improved sealing arrangement and eliminates the need for a cap for the imaging unit 660. An alternative of this embodiment is an arrangement where the handle 340 is bonded or integrally formed with the upper chamber of the imaging unit 660 during manufacture. This could allow the entire assembly of the imaging unit 660 with the monolithically formed handle 340 to be discarded with the imaging fluid contained therein.

The handle is provided with distance markers (markers 349a-c are shown in this partial view and more would be visible in a complete illustration of the handle 340) which indicate the distance from the center of rotation of the ball 291. This feature provides a means of identifying sideways movement of the handle 340 at a given distance from the center of rotation of the ball 291, which creates a known opposite movement of a trajectory of the same length as that distance.

FIG. 29 is a perspective view of the sub-assembly of the imaging unit 660 and the handle 340. FIG. 30 is a transparent perspective view of the imaging unit 660 which shows internal features including imaging passages 661a, 661d and 661g (remaining passages 661b, 661c, 661e and 661f are not visible in this view), passage extension 661a′ plenum 669 and reservoir 663. Likewise, FIG. 31 is a transparent perspective view of the handle 340 which shows the internal injection passage 348 and the injection port 346. In addition, distance markers 349a-i are shown as graduations at and above the connector 341. The internal injection passage 348 provides a convenient means for filling the imaging unit 660 with imaging fluid while the handle 340 and imaging unit 660 subassembly is assembled.

FIGS. 32 and 33A-33B illustrate one embodiment of imaging unit 660 and one embodiment of the ball array guide 390. The imaging unit 660 is seen in a perspective view in FIG. 32. The imaging unit 660 has a solid bottom 660′ indicating that all of the imaging passages 661a-g which begin at the bottom of the reservoir 663 terminate within the body of the imaging unit 660 (see FIG. 33B). The ball array guide 390 and the subassembly of both the ball array guide 390 and the imaging unit 660 are shown in perspective views in FIGS. 33A and 33B. The ball array guide 390 has a wide bore 392 which extends from the top through to the bottom of the ball 391. When the imaging unit 660 is fully inserted into the ball array guide 390, the solid bottom of the imaging unit 660′ is seen at the bottom of the ball 391.

FIGS. 34 and 35A-35B illustrate one embodiment of a catheter guide unit 720 and one embodiment of a ball array guide 490. The catheter guide unit 720, shown by itself in a perspective view in FIG. 34, is provided with an outer index lobe 726 to accommodate the presence of a shorter index lumen 724 which is outside of the hexagonal symmetry of the main pattern of lumens 725a-g (see FIG. 35B). The index lumen 724 is used for identification of the individual lumens 725a-g during imaging. In FIGS. 34 and 35A, the lumens 725a-g extend all the way from the top to the bottom of the catheter guide unit 720. These lumens 725a-g are visible in the bore 492 at the bottom of the ball 491 of the ball array guide in FIG. 35A. The ball array guide 490 is provided with an index lobe receiver portion 494 to accommodate the entry of the index lobe 726 of the catheter guide unit 720. The presence of the lobe 726 allows the catheter guide unit 720 to be constructed with a smaller diameter lower portion to make a tighter array of lumens 725a-g. The lobe receiver 494 of the ball array guide 490 provides an improvement over the outer groove arrangement of other embodiments of the ball array guide by protecting the index passage which is used during imaging.

Trajectory Array Guide System Having Separate Imaging Unit and Guide Units with Slanted Arrays

A trajectory array guide system can include a funnel-shaped ball array guide which includes matched arrays of lumens and imaging passages which are angled with respect to the longitudinal axis of the ball array guide. Such angled or slanted arrays may be designed to expand the range of possible trajectories outside of the typical straight array in which all lumens and passages are aligned with the longitudinal axis of the array guide. This can create a “footprint” three times the size of the single straight array. The advantage of this approach is that the ball-joint can remain in the locked position (i.e. adjustments of the ball-joint are not required). A single slanted imaging array could provide a wide range of additional trajectories arranged circumferentially around the central array when locked in various positions.

FIG. 36A shows a cross-sectional view of a subassembly of one embodiment of a funnel-shaped ball array guide 590 with a wide bore to accommodate insertion of a funnel-shaped imaging unit 1160. FIG. 36B is a top view of the same arrangement shown in FIG. 36A. Ball array guide 590 includes eight equi-spaced lock tabs 593a-h which are each configured to lock the ball array guide 590 to the imaging unit 1160 and to lock the ball array guide 590 to the matched catheter guide unit 1120 (see FIG. 36C). The index lock tab 593a (in the 12:00 position in FIG. 36B) is provided with a differentiating indicator such as a different color (as indicated by the black fill in FIG. 36B) for identification. The imaging unit 1160 has the usual hexagonal pattern of imaging passages 1161a-g and an index passage 1162 as seen in FIG. 36B. However, each of the passages 1161a-g is angled away from the longitudinal axis of the imaging unit 1160 as indicated by representative passages 1161a, 1161d and 1161g of FIG. 36A (the remaining passages 1161b, 1161c, 1161e and 1161f are hidden from view in this cross-section). The angled passages 1161a-g and index passage 1162 are substantially parallel and extend from the bottom of the reservoir 1163 to a position close to the bottom of the imaging unit 1160.

The placement of the single lock tab 1169 of the imaging unit (with locking using lock bolt 595a) in a position other than the index position shown in FIG. 36B will have the effect of rotating the trajectory direction of the hexagonal array of passages 1161a-g. Because each of the passages 1161a-g of the hexagonal array is angled, this rotation has the effect of shifting the direction of the array of potential trajectories to create a wider circle of end points for the potential trajectories as shown in FIGS. 37A and 37B.

FIG. 36C is a cross-sectional view of the subassembly of the ball array guide 590 with a catheter guide unit 1120 inserted into the wide bore of the ball array guide 590. This catheter guide unit 1120 is matched to the imaging unit 1160 and thus has slanted lumens 1125a-g and a slanted index lumen 1124 which match the passages 1125a-g and index passage 1162 of the imaging unit 1160. Thus, when the imaging unit 1160 is used to identify, an optimal trajectory passage, the lumen corresponding to that optimal trajectory passage will be used for injection of the catheter. For example, if imaging passage 1161d was identified as representing the optimal trajectory to the target, lumen 1125d of the matched catheter guide unit 1120 would be used as the pathway to inject the catheter. The catheter guide unit 1120 has a lock tab 1129 for locking the catheter guide unit 1120 to any one of the lock tabs 593a-i of the ball array guide 590 (see FIG. 36D).

The catheter guide unit 1120 also includes a locking slider 1126 with openings 1128a-g for locking a catheter in place within one of the selected lumens 1125a-g, This locking slider 1126 is shown by itself in a top view in FIG. 36E. The locking slider 1126 is secured to the catheter guide unit 1120 using lock bolt 595b.

As noted hereinabove, FIGS. 37A and 37B are provided to indicate how placement of imaging unit 1160 with its lock tab 1169 locked to any one of the lock tabs 593a-i will result in direction of the array of trajectories to a different outward location, which are identified using clock positions.

In accordance with the angular direction of the passages 1161a-g and lumens 1121a-g away from the index lock tab 593a (12:00 position), it is understood that the trajectories are directed in the opposite direction (towards the 6:00 position). Therefore, according to this arrangement, it is seen in FIGS. 37A and 37B that when the lock tab 1169 of imaging unit 1160 is locked to tab 593a (12:00 position), the array will be directed towards the 6:00 position. This opposing directivity holds for the remaining positions.

The use of ball array guide 590 may be combined with imaging units and catheter guide units with straight arrays such as those illustrated in FIGS. 26A-26H. Therefore, if imaging unit 960 of FIGS. 26A and 26B is inserted into the ball array guide 560, it can be locked to any one of lock tab positions 593a-i and the trajectory direction of the array will remain centralized with no outward directivity because the array of the imaging unit 960 is straight. Therefore, a combination of imaging and guide units with straight arrays and imaging and guide units with slanted arrays can cover a wide footprint as illustrated in FIG. 37B. Importantly the wide footprint of trajectory coverage may be obtained without adjusting the ball array guide 590 within its socket in the base plate.

Trajectory Array Guide System with Alternative Handle for Connection to Navigation Pointer for Image-Guided Surgery

An embodiment of a trajectory array guide system 19 is shown in FIGS. 38A-D. This embodiment includes a handle 440 which is constructed to facilitate connections to navigation pointers of image guided surgery systems currently in use. As such, the handle 440 (shown by itself in FIG. 38A) is designed for direct placement on and engagement with a ball array guide 320 which is seen as part of the complete system 19 in FIGS. 38B-38D. The placement is made by inserting a spike 448 into one of the selected lumens 325a-g (see FIG. 38D). The handle 440 is hollow to allow insertion of the spike 448 at one end. The hollow handle 440 also allows for the attachment a navigation pointer to the back end opening 446 of the hollow handle. A set-screw 447 penetrating into the bore of the handle 440 is provided to hold the navigation pointer in place,

FIG. 38B shows one embodiment of an assembled trajectory array guide system with the handle 440 engaged with an embodiment of the ball array guide 320 which has three set screws 323a-c positioned closer to the ball 321 than to the upper end of the ball array guide 320, This arrangement is provided to allow direct connection of certain types of surgical navigation systems to the upper part of the ball array guide 320, This system 19 uses base plate 450 in combination with ring clamp 80 as seen in FIGS. 38B-D.

FIG. 38C is an exploded view showing components of a trajectory array guide system 19, including imaging unit 360, reducer 75, and a calibration rod 201. In some embodiments, the calibration rod 201 can be used to calibrate positioning of the ball array guide 320 with respect to certain image guided surgery systems which can be connected directly to the upper body of the ball array guide 320. The calibration rod 201 has an upper portion with a wider diameter than the bottom portion to provide two calibration diameters to fit different sized holes. In one embodiment of the calibration rod, the wider portion of the calibration rod 201 has an outer diameter of 2.1 mm to fit the center lumen of the ball array guide 320 and the narrower portion of the calibration rod 201 has an outer diameter of 2.0 mm to fit into a calibration hole on the calibration tool of a Brainlab StarLINK™ image guided surgery system. This calibration rod 201 can also be compatible with the Medtronic SureTrak™ image guided surgery system, and other image guided surgery system known to those in the art. In some embodiments, trajectory array guide system 19 includes an O-ring 369 which creates a seal between the cap 364 and the imaging unit 360.

FIG. 38D is a top view of the system without the handle 440. The ball array guide 320 has three set-screw holes 326a-c which allow each set screw 323a-c to penetrate the body of the ball array guide 320 and enter three of the seven lumens 325a-g. Therefore, set-screw 323a penetrates into lumens 325a, 325b and 325g; set-screw 323b penetrates into lumens 325c, 325d and 325g: and set-screw 323c penetrates into lumens 325e, 325f and 325g. As such, the spike 448 can be fixed in place in any one of the seven lumens 325a-g.

In some embodiments, the position and orientation of a trajectory array guide system can be tracked by an image guided neuronavigational system via instrument trackers clamped to a handle or array guide. In certain embodiments, the trajectory array guide system will have general compatibility with image guided surgery systems including, but not limited to, Varioguide™ and StarLINK™ (Brainlab, AG, Munich, Germany), as well as Vertek™ and SureTrak™ (Medtronic). FIG. 39 shows a perspective view of a trajectory array guide system engaged with an image guided surgery system 1200 which includes a probe 1202. The probe 1202 can be inserted into or engaged with the end opening 446 of the handle 440. The image guided surgery system 1200 can be secured to the handle using fastening and locking mechanisms, including the set screw 447. FIG. 40A shows a perspective view of an image guided surgery system 1210 clamped onto a handle 440 of a trajectory array guide system. FIG. 40B shows a perspective view of an image guided surgery system 1210 clamped directly onto a ball array guide 320 of a trajectory array guide system, with the assistance of a calibration rod 201.

Kits

The present disclosure provides kits for assembly of various embodiments of the trajectory array guide system of the present disclosure. In some embodiments, components of a kit may be separately packaged or packaged together in any configuration rendering a package suitable for sterilization. Steam, ethylene oxide, or gamma sterilization are preferred sterilization methods for the kits.

In some embodiments, the kit includes instructions for assembly of a trajectory array guide system.

In some embodiments, the kit includes the following: instructions for assembly of a trajectory array guide system; a container of imaging reagent; and one or more catheters which are compatible with the trajectory array guide system.

In some embodiments, the kit includes multiple imaging units or guide units for insertion into an array guide. In some embodiments, the kit includes a plurality of separate array units or reducers configured for guiding elongated tools of different diameters.

EXAMPLES

Example 1—Testing of Locking Mechanism

Base plates resembling base plate 550 of FIG. 18 and base plate 450 of FIG. 19A were produced as plastic 3D-printed prototypes. A locking nut resembling locking nut 530 of FIG. 18 and a ring clamp resembling ring clamp 80 of FIGS. 19B-C were produced as plastic 3D-printed prototypes. The base plates were tested to determine the effectiveness of the locking mechanism.

The base plates were held in a vise at one of the attachment tabs. A ball array guide resembling the ball array guide 220 in FIG. 18 and FIG. 19D was engaged into the socket of each base plate. A downward force was applied 30 mm from the bottom face of the base plate. The speed of the downward force was set at 50 mm/min. The test was first conducted in the absence of a locking mechanism, and then with the tapered threading locking mechanism (similar to FIG. 18) and with the ring-clamp mechanism (similar to FIGS. 19A-19D) on their respective base plates. The peak force required to displace the ball array guide was recorded. The results of the test are summarized in Table 1.

TABLE 1
Testing of Locking Mechanisms
	Peak Force	Peak Torque
Locking Mechanism	(N)	(N) or (Nmm)	Failure Mode
Absent	1-2	30-60	Nmm	Ball moved
Tapered threading	7-8	210-240	Nmm	Ball moved
(similar to FIG. 18)
Ring-clamp (similar to	16-18	480-540N	Base plate
FIGS. 19A-19C)			tab fractured

The ring-clamp embodiment (similar to base plate 450 in combination with ring clamp 80 of FIGS. 19A-C) was found to yield the best results. The ring-clamp embodiment did not fail at a torque of 480-530 N which is twice the torque needed to fracture the catheter.

Example 2—Preparation of Imaging Cartridge

A gadolinium-based contrast solution is prepared by aspirating a gadolinium-based contrast agent into a 0.3 mL syringe. 0.04 mL of the gadolinium-based contrast agent is injected into a 10 mL pre-filled sterile saline syringe. A 2.0 to 5.0 inch, 25- to 30-gauge needle is attached to the sterile saline syringe and inverted multiple times to ensure mixing of the contrast agent with the sterile saline.

An imagining cartridge is provided which includes 7 imaging tubes in a symmetrical hexagonal pattern and an additional reference imagining tube. The 10 mL syringe containing the gadolinium imaging solution is used to sequentially fill the lumen of each tube by injecting imaging solution into the tube. The tip of the syringe is placed at the bottom of the tube, and the injection begins from the bottom of the tube. To ensure optimum MR visibility of the imaging cartridge tubes, the injection of the gadolinium imaging solution is continued while the syringe is slowly withdrawn from the tube, thereby preventing air from re-entering the tube. Each tube is visually inspected for air bubbles. If air bubbles are observed, the needle is reinserted to the base of the tube and additional gadolinium imaging solution is injected to push out the air bubbles.

Once all tubes have been filled with the gadolinium imaging solution, a reservoir at the top of the imaging cartridge is filled. An O-ring and sealing cap are then engaged with the top opening of the imaging cartridge to seal the imaging solution into the cartridge.

Example 3—Assembly of a Trajectory Array Guide System and Calibration with an Image Guided Surgery System

A trajectory array guide system resembling the system shown in FIG. 38C is provided. A ring clamp is engaged with a tilted base plate, such that the ridge of the ring clamp is engaged with the outer groove of the base plate, similar to the configuration shown in FIGS. 19B-19D. The tension screw of the ring clamp is maintained in a loose position, and the ball of a ball array guide is engaged into the socket of the base plate. The tension screw is softly tightened.

A component of an image guided surgery system, such as an instrument tracker, is attached to the handle of the trajectory array guide system in a manner resembling the configuration shown in FIG. 40A. The handle is then engaged with the ball array guide by inserting the spike of the handle into the center channel of the array guide. The set-screws of the ball array guide are tightened to secure the engagement.

The trajectory array guide system can then be adjusted as necessary, with the tension screw of the ring clamp being fully tightened once the system has been properly aligned.

Example 4—Assembly of a Trajectory Array Guide System without a Handle and Calibration with an Image Guided Surgery System

A trajectory array guide system resembling the system shown in FIG. 38C is provided. A ring clamp is engaged with a tilted base plate, such that the ridge of the ring clamp is engaged with the outer groove of the base plate, similar to the configuration shown in FIGS. 19B-19D. The tension screw of the ring clamp is maintained in a loose position.

A component of an image guided surgery system, such as an instrument tracker, is attached directly to a guide array of the trajectory array guide system, similar to the configuration shown in FIG. 40B. The ball of a ball array guide is then engaged into the socket of the base plate. The tension screw is softly tightened. A calibration rod is inserted into the center channel of the array guide.

The trajectory array guide system can then be adjusted as necessary, with the tension screw of the ring clamp being fully tightened once the system has been properly aligned.

Example 5—Surgical Preparation of a Skull and Attachment of Trajectory Array Guide System

A cranial entry point is identified using image guided neuronavigational systems and MRI scans. The target head area is prepared for cranial entry according to standard medical practice, including cleaning and shaving the scalp around the cranial entry point. A craniotomy is conducted using standard surgical procedures to form a cranial entry at least 14 mm diameter at the planned cranial entry site.

A trajectory array guide system is provided, such as the system described in Example 3. The base plate is placed against the skull at the cranial entry point, with the bore of the base plate being located directly over the cranial entry hole. The base is rotated to a suitable orientation for attachment to the skull and to ensure that the tilt of the base is aligned with the surgical target. The base is then attached to the skull using self-drilling titanium bone screws through the holes on the base feet. The ring clamp and array guide are rotated and adjusted as necessary to provide access to the screw holes.

Example 6—Alignment of Trajectory Guide System, Selection of Target Trajectory, and Completion of Surgical Procedure

A trajectory array guide system attached to a skull is provided, such as the arrangement described in Example 5.

The ring clamp is maintained in a loose position to allow the array guide to be freely rotated and adjusted as necessary. Using standard surgical procedures, an image guided surgery system is used to align the array guide in the direct of the surgical target. The trajectory and position of the array guide is then secured by gently hand-tightening the tension screw of the ring clamp.

A surgical probe is used to measure the distance from the top of the array guide to the surgical target, thereby providing the necessary insertion depth of the surgical instrument.

An imagining cartridge, such as the imaging cartridge prepared in Example 2, is carefully inserted into the array guide. The system is inspected to ensure that there is no gap between the top of the guide and the body of the imaging cartridge. Set-screws in the array guide are tightened to secure the engagement of the imaging cartridge and array guide.

All MRI unsafe tools, such as a metal handle or metal calibration rod are removed, and the head is placed within an MRI suite. The MRI equipment is turned on, and the resulting images are inspected to ensure that the entire trajectory array guide system and target surgical area are included in the MR images. Each of the seven trajectories is evaluated relative to the reference tube, and the best trajectory for the surgical target is selected. The channel corresponding to the selected trajectory is noted, and the imagining cartridge is removed.

The surgical procedure is then performed using the array channel of the selected trajectory. If the tube is a 14-gauge tube and the surgical instrument is a 16-gauge instrument, a reduce can be used to adjust the diameter of the array channel.

Once the surgical procedure is complete, the bone screws are withdrawn, and the trajectory array guide system is removed from the skull and disassembled. The trajectory array guide system can then be discarded as a single-use system, or it can be sterilized for reuse.

EQUIVALENTS AND SCOPE

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments in accordance with the disclosure described herein.

In the claims, articles such as “a,” “an,” and “the” may mean one or more than one unless indicated to the contrary or otherwise evident from the context. Claims or descriptions that include “or” between one or more members of a group are considered satisfied if one, more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process unless indicated to the contrary or otherwise evident from the context. members are present in, employed in, or otherwise relevant to a given product or process.

It is also noted that the term “comprising” is intended to be open and permits but does not require the inclusion of additional elements or steps. When the term “comprising” is used herein, the term “consisting of” is thus also encompassed and disclosed.

Methods of the present disclosure are exemplified through discussion of certain embodiments which are not intended to be limiting to the scope of the general methods disclosed herein. Certain embodiments of the methods are discussed with different combinations of steps and different orders of steps. The combinations and order in which steps are presented are not intended to be limiting to the scope of the general methods presently disclosed. Individual steps disclosed herein can be combined in any combination and in any order within operable embodiments of the methods according to the knowledge and skill of those with ordinary skill in the art.

Where ranges are given, endpoints are included. Furthermore, it is to be understood that unless otherwise indicated or otherwise evident from the context and understanding of one of ordinary skill in the art, values that are expressed as ranges can assume any specific value or subrange within the stated ranges in different embodiments of the invention, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise.

Any particular embodiment of the present disclosure that falls within the prior art may be explicitly excluded from any one or more of the claims. Since such embodiments are deemed to be known to one of ordinary skill in the art, they may be excluded even if the exclusion is not set forth explicitly herein. Any particular embodiment of the compositions of the invention (e.g., any nucleic acid or protein encoded thereby; any method of production; any method of use; etc.) can be excluded from any one or more claims, for any reason, whether or not related to the existence of prior art.

All cited sources, for example, references, publications, databases, database entries, and art cited herein, are incorporated into this application by reference, even if not expressly stated in the citation. In case of conflicting statements of a cited source and the instant application, the statement in the instant application shall control.

Section and table headings are not intended to be limiting. Figures included with the present disclosure are intended to be non-limiting depictions of general concepts of the present disclosure.

Claims

1. A trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory, the trajectory array guide system comprising: (a) a base configured for attachment to the skull of the subject;(b) an array guide comprising a series of lumens;(c) an imaging unit configured for engagement with the array guide and configured to hold and direct imaging fluid along passages which are co-axial with the lumens of the array guide and configured to define a series of trajectories; and(d) an elongated handle configured for engagement with either the array guide or the imaging unit.

2. The trajectory array guide system of claim 1, wherein the array guide comprises a ball at one end, and wherein the base comprise a socket configured to receive and hold the ball of the array guide to form a ball-socket pivoting mechanism.

3. The trajectory array guide system of claim 2, wherein the socket has a central axis orthogonal to a plane formed by the bottom of the base.

4. The trajectory array guide system of claim 2, wherein the socket has a central axis which is non-orthogonal with respect to the plane formed by the bottom of the base such that the socket is tilted.

5. The trajectory array guide system of claim 4, wherein the central axis of the socket is angled by between about 10 degrees to about 30 degrees from the axis orthogonal to the plane formed by the bottom of the base.

6. The trajectory array guide system of claim 2, wherein the socket has an outer sidewall comprising threads or one or more grooves, wherein the threads or the one or more grooves are configured for attachment to a locking element to prevent the ball within the socket from pivoting movement.

7. The trajectory array guide system of claim 6, wherein the locking element is a ring-clamp configured for connection to the one or more grooves of the socket.

8. The trajectory array guide system of claim 6, wherein the locking element is a locking nut configured for connection to the threads of the socket.

9. The trajectory array guide system of claim 6, wherein the base includes a plurality of attachment members for attaching the base to the skull of the subject, and wherein the attachment members are accessible by an attachment tool when the locking element is engaged to the outer sidewall of the socket.

10. The trajectory array guide system of claim 2, wherein the array guide comprises a cylindrical or funnel-shaped member having a first end and a second end, wherein the ball is formed at the first end, and wherein the series of lumens each separately extend longitudinally along the length of the array guide from the first end to the second end of the array guide.

11. The trajectory array guide system of claim 10, wherein the series of lumens comprises seven substantially parallel lumens with six lumens arranged in a symmetrical hexagonal pattern and a seventh lumen located in the center of the symmetrical hexagonal pattern.

12. The trajectory array guide system of claim 2, wherein the imaging unit comprises an upper reservoir in fluid communication with a series of lower extensions which are co-axial with the lumens of the array guide.

13. The trajectory array guide system of claim 12, wherein the lower extensions are tubes configured to fit inside the lumens of the array guide.

14. The trajectory array guide system of claim 13, wherein the array guide includes an outer groove and the imaging unit includes an index tube configured to slide into the outer groove when the imaging unit is engaged with the array guide, wherein the index tube is configured to provide a reference point for identification of each of the tubes in a magnetic resonance image.

15. The trajectory array guide system of claim 13, wherein the array guide comprises a mechanism for locking the tubes of the imaging unit in place within the array guide.

16. The trajectory array guide system of claim 15, wherein the locking mechanism includes at least one set-screw which penetrates the array guide and makes tightening contact with at least one of the tubes.

17. The trajectory array guide system of claim 15, wherein the locking system includes three set-screws, each penetrating the body of the array guide to enter two different lumens as well as the central lumen.

18. The trajectory array guide system of claim 17, wherein the three set-screws are placed closer to the ball of the ball array guide than to the upper end of the ball array guide.

19. The trajectory array guide system of claim 2, wherein the elongated handle comprises a connector end configured for engagement with the outside or the inside of the imaging unit.

20. The trajectory array guide system of claim 19, wherein the connector end is configured for engagement with the outside of the imaging unit and includes an opening for a connector set-screw to lock the elongated handle on the imaging unit.

21. The trajectory array guide system of claim 19, wherein the elongated handle includes an end spike for insertion into one of the lumens of the array guide for direct engagement of the elongated handle with the array guide.

22. The trajectory array guide system of claim 21, wherein the elongated handle is at least partially hollow and has an outer end opening at the end opposite the end spike, and wherein the outer end opening is configured for connection to a navigation component of an image guided surgery system.

23. The trajectory array guide system of claim 2, further comprising a reducer tube for insertion into one of the lumens to provide a reduced diameter for the lumen.

24. The trajectory array guide system of claim 23, wherein the reducer tube comprises an adjustable stop for restraining movement of an elongated tool within the reducer tube.

25. The trajectory array guide system of claim 1, wherein the imaging unit includes a cap configured to seal the imaging fluid inside the imaging unit.

26. The trajectory array guide system of claim 1, wherein the elongated handle is configured for connection with a stereotaxic navigation system.

27. The trajectory array guide system of claim 1, wherein the elongated handle is configured for engagement with at least one of the array guide and the imaging unit when the array guide and imaging unit are assembled together with the base.

28. A method for delivering an elongated tool to a target location in the brain of a subject, the method comprising: (a) providing a trajectory array guide system, the trajectory array guide system comprising a base, an array guide, an imaging unit, and a handle;(b) performing a craniotomy at an entry location;(c) connecting the base of the trajectory array guide system to the entry location;(d) engaging the array guide with the base to form a pivoting mechanism;(e) engaging the imaging unit with the array guide and aligning the array guide to target the location;(f) imaging a series of trajectories towards the target location with magnetic resonance imaging (MRI);(g) locking the trajectory array guide system and selecting a trajectory from the series of trajectories;(h) removing the imaging unit and delivering the elongated tool to target location using the selected trajectory; and(i) removing the trajectory array guide system from the skull of the subject.

29. The method of claim 28, wherein the step of connecting the base of the trajectory array guide system to the entry location comprises connecting the base to the entry location using bone screws through bottom tabs of the base.

30. The method of claim 28, wherein the method further comprises adding MRI contrast imaging reagent to the imaging unit prior to the imaging of the series of trajectories.

31. The method of claim 28, wherein the step of aligning the array guide to the target location comprises using the surgical navigation system to orient the series of trajectories toward the target location.

32. The method of claim 28, wherein the elongated tool is a catheter configured to deliver a drug to the target location.

33. The method of claim 28, wherein (a) the base is configured for attachment to the skull of the subject;(b) the array guide comprises a series of lumens;(c) the imaging unit is configured for engagement with the array guide and configured to hold and direct imaging fluid along passages which are co-axial with the lumens of the array guide and configured to define a series of trajectories; and(d) the handle is configured for engagement with either the array guide or the imaging unit;wherein the array guide comprises a ball at one end, and wherein the base comprise a socket configured to receive and hold the ball of the array guide to form a ball-socket pivoting mechanism.

34. The method of claim 33, further comprising engaging the handle with at least one of the array guide and the imaging unit while the array guide and imaging unit are assembled together with the base.

35. The method of claim 28, wherein the trajectory array guide system comprises a stereotaxic navigation system connected to the handle.

36. A kit for providing a trajectory array guide system, the kit comprising: (a) an array guide comprising a series of lumens and a ball at one end;(b) a base configured for attachment to the skull of the subject, wherein the base comprises a socket configured to receive and hold the ball of the array guide to form a ball-socket pivoting mechanism;(c) an imaging unit configured for engagement with the array guide and configured to hold and direct imaging fluid along passages which are co-axial with the lumens of the array guide and configured to define a series of trajectories; and(d) an elongated handle configured for engagement with either the array guide or the imaging unit.

37. The kit of claim 36 further comprising one or more elongated tools configured to deliver a drug to a target location, wherein the elongated tools comprise one or more catheters.

38. The kit of claim 36, wherein all components are contained in one or more sterilized packages.

39. The kit of claim 36, wherein the elongated handle is configured for connection with a stereotaxic navigation system.

40. The kit of claim 36, wherein the elongated handle is configured for engagement with at least one of the array guide and the imaging unit when the array guide and imaging unit are assembled together with the base.