TRANSCRIPT OPTIMIZED EXPRESSION ENHANCEMENT FOR HIGH-LEVEL PRODUCTION OF PROTEINS AND PROTEIN DOMAINS

BACKGROUND

The production of recombinant proteins and protein domains as reagents is extremely valuable to biomedical researchers and the entire biotechnology industry. Escherichia coli expression systems are the most cost effective and widely utilized expression systems for this task. However, production of certain proteins can be challenging in this bacterial system. Often proteins or protein domains fail to express at sufficient levels to allow for the purification of the protein reagents. This is especially true of the protein coding sequences derived from higher eukaryotes (such as humans). For example, using a standard pET E. coli expression system (Acton et al., 2011), nearly one-third of human protein targets produced in a large scale screen of protein expression had no detectable expression levels.

Thus, there is a need for agents and methods for high-level production of recombinant proteins and protein domains that do not require RNA optimization for each individual target gene.

SUMMARY OF CERTAIN EMBODIMENTS OF THE INVENTION

This invention relates to a system for high-level production of recombinant proteins and protein domains that does not require RNA optimization for each individual target gene.

Certain embodiments of the invention provide a method of preparing an expression vector, wherein the expression vector comprises, in order of position: a first nucleic acid sequence encoding a 5′ untranslated region of an expressed mRNA that comprises a ribosome binding site (RBS); a second nucleic acid sequence encoding a polypeptide tag; and a cloning site, wherein the cloning site enables a target protein coding sequence to be inserted into the vector in-frame with the second nucleic acid sequence to encode a fusion protein comprising the polypeptide tag and the target protein; and wherein the method comprises specifically modifying the nucleic acid sequence encoding (i) the 5′ untranslated region and (ii) the adjacent polypeptide tag to minimize RNA secondary structure both within and/or between these two regions of the mRNA.

Certain embodiments of the invention provide an expression vector designed using the methods described herein.

Certain embodiments of the invention provide an expression vector comprising, in order of position: a first nucleic acid sequence encoding a 5′ untranslated region of an expressed mRNA that comprises a ribosome binding site (RBS); a second nucleic acid sequence encoding a polypeptide tag; and a cloning site, wherein the cloning site enables a target protein coding sequence to be inserted into the vector in-frame with the second nucleic acid sequence to encode a fusion protein comprising the polypeptide tag and the target protein; and wherein the nucleic acid sequence encoding (i) the 5′ untranslated region and (ii) the adjacent polypeptide tag has been specifically modified to minimize RNA secondary structure both within and/or between these two regions of the mRNA.

Certain embodiments of the invention provide a host cell comprising an expression vector as described herein.

The details of one or more embodiments of the invention are set forth in the description below. Other features, objects, and advantages of the invention will be apparent from the description and from the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a set of diagrams showing sequences of Avi-tag and Nano-tag based Transcript-Optimized Expression Enhancement Technology (TOEET) expression vectors. The pNESG_Avi6HT Avi-tag sequence (top) (DNA, RNA and protein sequence), the His-tag sequences and the TEV Protease Recognition Site sequences are shown as indicated. Similarly, for pNESG_Nano6HT (bottom) the Nano-tag sequences, the His-tag sequences and TEV Protease Recognition Site sequences are shown as indicated. The T7 RNA transcript produced by each vector is shown under each vector with untranslated sequences indicated with brackets. The Multiple Cloning Site (MCS) is also shown after the tag sequences, including the positions and identity of restriction sites available for cloning.

FIG. 2 is a diagram showing the predicted mRNA secondary structure resulting from T7-RNA Polymerase based transcription off of the pNESG_Avi6HT T7 promoter. Numbering of the transcript from nucleotides 1-156 is indicated; negative numbers (in italics) show the estimated strength, in kcal/mole, of the predicted base-paired regions. The arrow indicates a predicted open structure (lack of base pairing) at the RBS/translation initiation region. RNA secondary structure predictions were done using GeneBee-NET (http://www.genebee.msu.su/services/rna2_reduced.html).

FIG. 3 is a set of photographs showing representative SDS-PAGE analysis of expression and solubility for two human protein domains cloned into each of the three vectors pET15_NESG, pNESG_Nano6HT and pNESG_Avi6HT. Left Panel shows the expression and solubility of HR7724C (HUGO ID: ZNF281) residues 291-374. Right Panel shows the expression and solubility of HR8241 (HUGO ID: NR4A21) residues 261-342. Total cell lysate (Tot) and the soluble portion (Sol) of the cell lysate are run in adjacent lanes for each of the two protein domains and the three expression vectors. An asterisk (*) indicates an overexpressed band of the correct size. Note the lack of protein expression in the case of pET15_NESG constructs.

FIG. 4. Wild-Type and TOEET-Optimized Pyrococcus furiosus (PfR) Maltose Binding Protein (MBP). The sequences at the top corresponds to the first 30 residues of the wild-type PfR-MBP DNA sequence lacking the native secretion signal. The protein open reading frame (DNA sequence) is shown above the corresponding protein sequence. Directly below is the T7 RNA polymerase mediated RNA transcript resulting from the cloning of the PfR-MBP into the pET15_NESG backbone. The Ribosome Binding Site (RBS) is underlined and highlighted in bold, the translation initiation codon is shown in bold-italics. The lower set of sequences correspond to TOEET-optimized PfR-MBP. Bold nucleotides with arrows indicate positions where silent mutations were introduced for codon optimization, predicted decrease in RNA secondary structure in the regions of the RBS and translation initiation codon, or both. The RNA transcript for the TOEET optimized sequence is also shown following the parameters outlined above. The silent mutations were introduced using primers incorporating the nucleotide changes and 5 successive rounds of PCR, negating the need for expensive total gene synthesis.

FIG. 5. The predicted mRNA secondary structure resulting from T7-RNA Polymerase based transcription off of the pET15_NESG vector backbone with Pyrococcus furiosus (PfR) Maltose Binding Protein (MBP) without TOEET optimization. The arrows indicate significant secondary structure (base pairing) at both the Ribosome Binding Site (RBS) and the translation initiation site (Initiation Codon). RNA secondary structure predictions were performed using GeneBee-NET (http://www.genebee.msu.su/services/rna2_reduced.html).

FIG. 6. The predicted mRNA secondary structure resulting from T7-RNA Polymerase based transcription off of the pET15_NESG vector backbone with Pyrococcus furiosus (PfR) Maltose Binding Protein (MBP) after TOEET optimization. The arrows indicates the Ribosome Binding Site (RBS) and the translation initiation site (Initiation Codon) and the prediction of significantly greater open structure (lack of base pairing) after TOEET optimization. RNA secondary structure predictions were done using GeneBee-NET (http://www.genebee.msu.su/services/rna2_reduced.html).

FIG. 7. Histogram plots comparing Expression scores (E ranging from 0 to 5) using the TOEET technology (E_TOEET) compared to expression scores for the same target protein using a pET vector lacking TOEET technology (E_pET). The data shown in FIG. 7a is for 98 protein target genes cloned into the pNESG_Avi6HT TOEET vector compared with the exact same genes cloned into the pET15_NESG vector (lacking TOEET). The data shown in FIG. 7b is for 94 protein target genes cloned into the pNESG_Nano6HT TOEET vector compared with the exact same genes cloned into pET15_NESG vector (lacking TOEET). In these histogram plots, a value E_TOEET−E_pET=0 indicates that the expression levels for both vectors were identical; values E_TOEET−E_pET>0 indicate that the TOEET technology provided higher level expression, values E_TOEET−E_pET<0 indicate that the TOEET technology provided lower level expression.

DETAILED DESCRIPTION

mRNA stem-loop structures often inhibit translation initiation and therefore reduce recombinant protein expression (Nomura et al., 1984). High level expression of proteins is affected by a lack of mRNA secondary structure near the translation start site (Kudla et al., 2009; Rocha et al., 1999). In addition, rare codons present within the first ten residues of a protein have deleterious effects on protein expression levels (Gonzalez de Valdivia and Isaksson, 2004). E. coli, like all organisms, prefers to use a subset of the possible codons. The codons that an organism utilizes only infrequently are termed “rare codons” of that organism.

Heterologous genes from other organisms, which generally have a different codon bias, often contain E. coli rare codons. Decreasing or minimizing mRNA secondary structure near the Ribosome Binding Site (RBS) and translation initiation site, and separately that a lack of rare codons near the start of translation, are important for high level E. coli protein expression (Gonzalez de Valdivia and Isaksson, 2004; Kudla et al., 2009). However, the DNA coding sequence of a target gene destined for heterologous expression in E. coli has evolved under different conditions and may intrinsically contain deleterious rare codons and mRNA secondary structure when cloned into an expression vector. Deleterious rare codons and mRNA secondary structure features are particularly problematic when expressing domains or specific segments of target proteins; e.g., gene segments coding for fragments other than the native N-terminal region of the protein have not evolved to provide for efficient translation initiation. Total gene synthesis, or the chemical synthesis of a protein coding region, may address these problems to some extent, since the DNA sequence can be optimized to reduce these issues (Quan et al., 2011). However, the costs of total gene synthesis are prohibitive for large sets of protein targets, and generally is not suitable for large-scale screening or projects involving expression of many different proteins.

This invention is based, at least in part, on an unexpected discovery of a new methodology for achieving high-level production of recombinant proteins and protein domains. RNA sequence optimization is a well-known approach for improving protein expression. A feature of the system described herein is that RNA sequence optimization is required only in DNA comprising the vector backbone, including the DNA coding for the 5′-UTR and a common N-terminal polypeptide tag. Each target gene, coding for various target proteins, that is cloned into this vector backbone, need not be optimized individually. Hence, the optimized vector backbone can be used to enhance expression of many different target proteins without the need for target-protein-specific gene sequence optimization. Unlike certain previous methods, gene-by-gene RNA transcript sequence optimization is not required in certain embodiments of the methods described herein. The methodology includes, among others, jointly designing and optimizing sequences encoding 5′ untranslated and 5′ translated regions of the mRNA transcript produced by an expression vector so as to minimize RNA secondary structure and/or optimize codon usage in the mRNA transcript.

In one aspect, this invention addresses, among others, the problems associated with mRNA secondary structure and codon bias. Accordingly, the invention provides systems for high-level production of recombinant proteins and protein domains based on the Transcript-Optimized Expression Enhancement Technology (TOEET). As disclosed herein, TOEET is used to design expression vectors that produce mRNA transcripts with minimal RNA secondary structure and optimum codon usage in the nucleotide region around the Ribosomal Binding Site (RBS) and the translation initiation site, as well as minimal RNA secondary structure and optimal codon usage in a region of the transcript coding for an N-terminal polypeptide tag that is encoded directly downstream of the translation initiation site. Optimization can extend up to approximately 100 or more nucleotides on each of the 5′ and 3′ sides of the RBS. This generally will involve producing a protein with an N-terminal polypeptide tag, which is called an Expression Enhancement Tag (EET). This EET may be designed with other features that support protein production, such as solubility enhancing properties or affinity purification sequence motifs. Solubility enhancing tags known from the literature include the maltose-binding protein, the B1 domain of protein G, and domain of myxococcus protein S, to name a few representative examples. Expression vectors designed with TOEET allow most genes of interest to be produced with enhanced expression.

An advantage of the TOEET strategy over target gene optimization by total gene synthesis is that unless the 5′ end of the synthetic gene is optimized in the context of the untranslated vector sequences, detrimental mRNA secondary structure may form near or around the RBS/translation initiation site. More specifically, even if the 5′ translated region of the target gene is optimized by gene synthesis or by specific mutations, enhanced expression may not be realized unless the 5′-translated and 5′-untranslated regions of the transcript are jointly optimized, as described herein. Furthermore, by using a sufficiently long N-terminal EET tag, translated from an optimized RNA sequence that is encoded by the vector itself, there is no need to optimize the sequence of the target gene, avoiding the need for gene-specific synthesis or modification. This feature allows the TOEET technology to be used for target protein expression enhancement in high throughput applications, including expression screening studies and projects involving expression of many different proteins, where gene-specific synthesis or modification would be costly or impractical. The roughly 30 amino-acid residue (or larger) EETs effectively shift any deleterious RNA features of the target gene transcript significantly downstream of the RBS/translation initiation site, so that any potential RNA secondary structure formation with the 5′ end of the transcript is avoided, and any RNA secondary structure within the RNA coded for by the target gene itself will likely have little or no effect on expression. This TOEET strategy, which is independent of the target gene sequence, could be used more generally to enhance the expression levels of proteins produced with almost any expression vector or system.

Accordingly, certain embodiments of the invention provide a method of preparing an expression vector, wherein the expression vector comprises, in order of position: a first nucleic acid sequence encoding a 5′ untranslated region (UTR) of an expressed mRNA that comprises a ribosome binding site (RBS); a second nucleic acid sequence encoding a polypeptide tag (i.e., at the N-terminal end of the expressed target protein); and a cloning site, wherein the cloning site enables a target protein coding sequence to be inserted into the vector in-frame with the second nucleic acid sequence to encode a fusion protein comprising the polypeptide tag and the target protein; and wherein the method comprises specifically modifying the nucleic acid sequence encoding (i) the 5′ untranslated region and (ii) the adjacent polypeptide tag to minimize RNA secondary structure both within and/or between these two regions of the mRNA.

As used herein, a vector refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. The vector can be capable of autonomous replication or integrate into a host DNA. Examples of the vector include a plasmid, cosmid, or viral vector. The vector of this invention includes a nucleic acid in a form suitable for expression of the nucleic acid in a host cell. Preferably the vector includes one or more regulatory sequences operatively linked to the nucleic acid sequence to be expressed. A “regulatory sequence” includes promoters, enhancers, repressor binding sites, and other expression control elements (e.g., polyadenylation signals). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence, as well as tissue-specific regulatory and/or inducible sequences. For example, in certain embodiments of the invention, an expression vector described herein comprises a 5′ upstream sequence encoding an operable promoter and associated regulatory sequences. The design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, and the like.

As used herein, the 5′UTR of the encoded messenger RNA is transcribed from a promoter and includes a ribosome binding site several nucleotides preceding the start codon.

As used herein, a “cloning site” enables a sequence, such as, e.g., a target protein coding sequence, to be inserted into an expression vector. For example, the cloning site may be a multiple cloning site (MCS), also known as a polylinker, which is a short nucleic acid sequence that contains many restriction sites. For example, FIG. 1 shows a multiple cloning site, comprising a series of restriction enzyme recognition sites. In certain embodiments, the sequence is inserted in-frame, enabling expression of the inserted sequence. In certain embodiments, after the sequence, such as, e.g., the target protein coding sequence, has been inserted into the cloning site of the vector, a portion of the cloning site remains as flanking sequence on one or both sides of the inserted sequence. In other embodiments, the cloning site no longer remains after the insertion of the sequence into the cloning site of the vector.

As described herein, the nucleic acid sequence encoding (i) the 5′ untranslated region and (ii) the adjacent polypeptide tag may be specifically modified to minimize RNA secondary structure both within and/or between these two regions of the mRNA. In certain embodiments, one feature of the method described herein is that RNA optimization is required only in DNA comprising the vector backbone, including the DNA coding for the 5′-UTR and a common N-terminal polypeptide tag, and each gene coding for various target proteins, that is cloned into this vector backbone, need not be optimized individually. Accordingly, nucleic acids within the specific sequence encoding the 5′ untranslated region and the adjacent polypeptide tag are replaced with different nucleic acids to minimize RNA secondary structure of the expressed mRNA as described herein. In particular, in certain embodiments, the RNA secondary structure is minimized in the region surrounding the RBS and/or translation initiation site of the expressed mRNA. For example, nucleic acids are replaced to reduce base pairing with the RBS and/or translation initiation site of the expressed mRNA. In certain embodiments, the nucleic acid sequence directly surrounding the RBS site and/or the translation initiation site (e.g., the consensus sequences and sequences between these two sites) is minimally modified or not modified. For example, after modification the RBS site and the translation initiation site remain functionally active. In certain embodiments, nucleotides within the nucleic acid sequence encoding the polypeptide tag are modified in a manner that results in silent mutations.

Prediction of RNA secondary structure can be readily determined by one skilled in the art using techniques and tools known in the art. For example, a skilled artisan may use RNA structure prediction software, including CentroidFold (Hamada et al., 2009), CentroidHomfold (Hamada et al., 2009), CONTRAfold (Do et al., 2006), CyloFold (Bindewald et al.), KineFold (Xayaphoummine et al., 2005; Xayaphoummine et al., 2003), Mfold (Zuker and Stiegler, 1981), GeneBee-NET (Brodskii et al., 1995), (Pknots (Rivas and Eddy, 1999), PknotsRG (Reeder et al., 2007), RNAl23 (www.rna123.com), RNAfold (Gruber et al., 2008), RNAshapes (Voss et al., 2006), RNAstructure (Mathews et al., 2004), Sfold (Ding et al., 2004), UNAFold (Markham and Zuker, 2008), Crumple (Schroeder et al., 2011), and Sliding Windows & Assembly (Schroeder et al., 2011) among others.

As described herein, a target protein may refer to any of the following non-limiting embodiments: a full-length naturally occurring protein, a polypeptide sequence corresponding to a fragment or domain of a naturally occurring protein sequence, a mutant or modified form of a full-length protein or protein fragment, or a polypeptide sequence coding for a non-natural protein, such as proteins that have been engineered or designed by artificial methods.

Certain embodiments of the invention provide a method of preparing an expression vector, wherein the expression vector comprises, in order of position, a 5′ upstream sequence encoding an operable promoter and associated regulatory signals, a sequence encoding the 5′ untranslated region of the messenger RNA transcribed from the promoter including a ribosome binding site several nucleotides preceding the translation start codon, a sequence beginning with the start codon encoding a polypeptide tag, and a cloning site that enables “target protein” coding sequences to be inserted into the vector in-frame with the polypeptide tag thus allowing their expression as fusions to the polypeptide tag, wherein the method comprises specifically modifying the entire sequence encoding the 5′ untranslated region of the messenger RNA through and including the sequence encoding the polypeptide tag sequence in order to minimize RNA secondary structure upstream of the target insertion site.

In certain embodiments, the method further comprises specifically modifying the second nucleic acid sequence to reduce the presence of rare codons (i.e. mRNA codons for which the corresponding tRNAs are in low abundance in the host cell). For example, rare codons are replaced with high frequency codons to increase expression of any target protein expressed by the vector. Codons that are considered rare are dependent on the selected host cell that is used for expression of the vector and are known to and/or can be readily determined by one skilled in the art. For example, rare codons may be identified using computer software programs known in the art, for example, the Rare Codon Calculator (RaCC) for E. coli (http://nihserver.mbi.ucla.edu/RACC/), http://www.jcat.de/, or http://genomes.urv.es/OPTIMIZER/.

In certain embodiments, the modified region of the nucleic acid sequence spans from the first 5′ nucleotide in the expressed mRNA to the last nucleotide of the polypeptide tag.

In certain embodiments, nucleotides within about the last 20 nucleotides of the first nucleic acid sequence are modified (i.e., from the nucleotide that directly precedes the encoded start codon to 20 nucleotides upstream). In certain embodiments, nucleotides within about the last, e.g., 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 525, 550, 575, 600, 625, 650, 675, 700, 725, 750, 775, 800, 825, 850, 875, 900, 925, 950, 975 or 1,000 nucleotides of the first nucleic acid sequence are modified.

In certain embodiments, nucleotides within about the first 20 nucleotides of the second nucleic acid sequence are modified (i.e., from the first nucleotide within the encoded start codon to 20 nucleotides downstream). In certain embodiments, nucleotides within about the first, e.g., 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 525, 550, 575, 600, 625, 650, 675, 700, 725, 750, 775, 800, 825, 850, 875, 900, 925, 950, 975 or 1,000 nucleotides of the second nucleic acid sequence are modified.

In certain embodiments, the expression vector further comprises a target protein coding sequence inserted into the vector in-frame with the nucleic acid tag sequence to encode a fusion protein comprising the polypeptide tag and the target protein.

In certain embodiments, the target protein coding sequence is not modified to minimize RNA secondary structure.

In certain embodiments, the target protein coding sequence is not modified to reduce the presence of rare codons.

In certain embodiments, the target protein coding sequence is modified to minimize RNA secondary structure.

In certain embodiments, the target protein coding sequence is modified to reduce the presence of rare codons.

As used herein, the second nucleic acid sequence encodes at least one polypeptide tag. In certain embodiments, the second nucleic acid sequence encodes more than one polypeptide tag. As used herein, when the second nucleic acid sequence encodes more than one polypeptide tag, the respective sequences that encode each polypeptide tag are joined in-frame to result in a fusion protein that comprises each polypeptide tag. In certain embodiments, the second nucleic acid sequence encodes, e.g., two, three, four, five, etc. polypeptide tags.

As used herein, the second nucleic acid sequence may encode any polypeptide tag appropriate to the particular chosen application or selected target protein (e.g., an affinity purification tag and/or a solubility enhancement tag). Polypeptide tags are known to those skilled in the art. For example, the encoded polypeptide tag may be an Avi-tag, Calmodulin-tag, FLAG-tag, HA-tag, His-tag, Myc-tag, S-tag, SBP-tag, Softag 1, Softag 3, V5 tag, Xpress tag, Isopeptag, Spy tag, BCCP, Glutathione-S-transferase-tag, Green fluorescent protein-tag, Maltose binding protein-tag, Nus-tag, Strep-tag, Thioredoxin-tag, TC tag, Ty tag, Nano-tag, Halo-tag, protein G B1 domain tag, a myxococcus protein S tag or Protein A tag.

Accordingly, in certain embodiments, the at least one encoded polypeptide tag is selected from an Avi-tag, Calmodulin-tag, FLAG-tag, HA-tag, His-tag, Myc-tag, S-tag, SBP-tag, Softag 1, Softag 3, V5 tag, Xpress tag, Isopeptag, Spy tag, BCCP, Glutathione-S-transferase-tag, Green fluorescent protein-tag, Maltose binding protein-tag, Nus-tag, Strep-tag, Thioredoxin-tag, TC tag, Ty tag, Nano-tag, Halo-tag, protein G B1 domain tag, a myxococcus protein S tag or Protein A tag.

In certain embodiments, the second nucleic acid sequence encodes at least one affinity purification tag.

In certain embodiments, the second nucleic acid sequence encodes more than one affinity purification tag.

In certain embodiments, the second nucleic acid sequence encodes two affinity purification tags.

In certain embodiments, the encoded affinity purification tag(s) is/are selected from a Streptavidin binding moiety, a maltose binding protein moiety, and a HIS tag.

In certain embodiments, the Streptavidin binding moiety is a Nano-tag or a biotinylated Avi-tag.

In certain embodiments, the second nucleic acid sequence encodes no affinity purification tags.

In certain embodiments, the second nucleic acid sequence encodes at least one solubility enhancement tag.

In certain embodiments, the second nucleic acid sequence encodes more than one solubility enhancement tag.

In certain embodiments, the second nucleic acid sequence encodes two solubility enhancement tags.

In certain embodiments, the encoded solubility enhancement tag(s) is/are selected from a maltose binding protein tag, a protein G B1 domain tag, and a myxococcus protein S tag.

In certain embodiments, the second nucleic acid sequence encodes no solubility enhancement tags.

In certain embodiments, the second nucleic acid sequence further encodes at least one protease recognition site. In certain embodiments, the second nucleic acid sequence encodes more than one protease recognition site.

As used herein, when the second nucleic acid sequence further encodes a protease recognition site(s), the sequence that encodes this/these site(s) is/are inserted in-frame with the sequence(s) that encode the at least one polypeptide tag to result in a fusion protein that comprises the polypeptide tag(s) and the protease recognition site(s). In certain embodiments, the encoded protease recognition site(s) is/are downstream of the encoded polypeptide tag(s). In certain embodiments, the encoded protease recognition site is/are between a series of encoded polypeptide tag(s).

In certain embodiments, the protease recognition site(s) is/are a Tobacco Etch Virus (TEV), Thrombin, Factor Xa and/or a human rhinovirus (HRV) 3C (e.g., PreScission Protease, GE Healthcare Life Sciences, Pittsburgh, Pa.) protease recognition site.

As described herein, the PreScission Protease is a genetically engineered protein consisting of human rhinovirus 3C protease. It is often produced as a fusion protein with a hexaHis or GST affinity purification tag. It specifically cleaves between the Gln and Gly residues of the recognition sequence of LeuGluValLeuPheGln/GlyPro.

In certain embodiments, the second nucleic acid sequence is at least about 21 nucleotides in length. In certain embodiments, the second nucleic acid sequence is at least about, e.g., 24, 27, 30, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60, 63, 66, 69, 72, 75, 78, 81, 84, 87, 90, 93, 96, 99, 102, 105, 108, 111, 114, 117, 120, 123, 126, 129, 132, 135, 138, 141, 144, 147, 150, 201, 252, 303, 354, 405, 456, 507, 558, 609, 660, 711, 762, 813, 864, 915, 966, or 1,017 nucleotides in length.

In certain embodiments, the target protein coding sequence encodes a transcription factor, a transcription factor domain, an epigenetic regulatory factor, or an epigenetic regulatory factor domain.

In certain embodiments, the target protein coding sequence encodes a polypeptide sequence described in Table 2. As described herein, the target protein coding sequence may also encode a polypeptide sequence that has substantial identity to or is a functional equivalent of a polypeptide sequence described in Table 2.

In certain embodiments, the target protein coding sequence encodes a protein antigen for producing an affinity capture reagent.

In certain embodiments, the affinity capture reagent is an antibody, an antibody fragment, or an aptamer.

In certain embodiments, the target protein coding sequence encodes a protein antigen for producing an antibody or Fab by phage display.

In certain embodiments, the expression of the target protein is about 1.5 fold greater than the expression of a target protein generated from an expression vector that was not modified as described herein. In certain embodiments, the expression of the target protein is, e.g., about 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5, or 20, etc., fold greater than the expression of a target protein generated from an expression vector that was not modified as described herein.

As described herein, in certain embodiments, expression of a target protein from a vector that is not TOEET modified as described herein is undetectable, whereas expression of the same target protein from a vector that has been modified as described herein is detectable.

Certain embodiments of the invention provide an expression vector prepared using a method as described herein.

Certain embodiments of the invention provide a target protein expression vector (e.g. a target protein expression vector) comprising, in order of position: a first nucleic acid sequence encoding a 5′ untranslated region of an expressed mRNA that comprises a ribosome binding site (RBS); a second nucleic acid sequence encoding a polypeptide tag; and a cloning site, wherein the cloning site enables a target protein coding sequence to be inserted into the vector in-frame with the second nucleic acid sequence to encode a fusion protein comprising the polypeptide tag and the target protein; and wherein the nucleic acid sequence encoding (i) the 5′ untranslated region and (ii) the adjacent polypeptide tag has been specifically modified to minimize RNA secondary structure both within and/or between these two regions of the mRNA.

In certain embodiments, the second nucleic acid sequence has been specifically modified to reduce the presence of rare codons.

In certain embodiments, the modified region of the nucleic acid sequence spans from the first 5′ nucleotide in the expressed mRNA to the last nucleotide of the polypeptide tag.

In certain embodiments, nucleotides within about the last 20 nucleotides of the first nucleic acid sequence have been modified (i.e., from the nucleotide that directly precedes the encoded start codon to 20 nucleotides upstream). In certain embodiments, nucleotides within about the last, e.g., 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 525, 550, 575, 600, 625, 650, 675, 700, 725, 750, 775, 800, 825, 850, 875, 900, 925, 950, 975 or 1,000 nucleotides of the first nucleic acid sequence have been modified.

In certain embodiments, nucleotides within about the first 20 nucleotides of the second nucleic acid sequence have been modified (i.e., from the first nucleotide within the encoded start codon to 20 nucleotides downstream). In certain embodiments, nucleotides within about the first, e.g., 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 525, 550, 575, 600, 625, 650, 675, 700, 725, 750, 775, 800, 825, 850, 875, 900, 925, 950, 975 or 1,000 nucleotides of the second nucleic acid sequence have been modified.

In certain embodiments, an expression vector as described herein, further comprises a target protein coding sequence inserted into the vector in-frame with the nucleic acid tag sequence to encode a fusion protein comprising the polypeptide tag and the target protein.

In certain embodiments, the target protein coding sequence has not been modified to minimize RNA secondary structure.

In certain embodiments, the target protein coding sequence has not been modified to eliminate rare codons.

In certain embodiments, the target protein coding sequence has been modified to minimize RNA secondary structure.

In certain embodiments, the target protein coding sequence has been modified to eliminate rare codons.

In certain embodiments, the second nucleic acid sequence encodes at least one affinity purification tag.

In certain embodiments, the second nucleic acid sequence encodes more than one polypeptide tag. As used herein, when the second nucleic acid sequence encodes more than one polypeptide tag, the respective sequences that encode each polypeptide tag are joined in-frame to result in a fusion protein that comprises each polypeptide tag. In certain embodiments, the second nucleic acid sequence encodes, e.g., two, three, four, five, etc. polypeptide tags.

As used herein, the second nucleic acid sequence may encode any polypeptide tag appropriate to the particular chosen application or selected target protein (e.g., an affinity purification tag or a solubility enhancement tag). Polypeptide tags are known to those skilled in the art. For example, the encoded polypeptide tag may be an Avi-tag, Calmodulin-tag, FLAG-tag, HA-tag, His-tag, Myc-tag, S-tag, SBP-tag, Softag 1, Softag 3, V5 tag, Xpress tag, Isopeptag, Spy tag, BCCP, Glutathione-S-transferase-tag, Green fluorescent protein-tag, Maltose binding protein-tag, Nus-tag, Strep-tag, Thioredoxin-tag, TC tag, Ty tag, Nano-tag, Halo-tag, protein G B1 domain tag, a myxococcus protein S tag or Protein A tag.

Accordingly, in certain embodiments, the at least one encoded polypeptide tag is selected from an Avi-tag, Calmodulin-tag, FLAG-tag, HA-tag, His-tag, Myc-tag, S-tag, SBP-tag, Softag 1, Softag 3, V5 tag, Xpress tag, Isopeptag, Spy tag, BCCP, Glutathione-S-transferase-tag, Green fluorescent protein-tag, Maltose binding protein-tag, Nus-tag, Strep-tag, Thioredoxin-tag, TC tag, Ty tag, Nano-tag, Halo-tag, protein. G B1 domain tag, a myxococcus protein S tag or Protein A tag.

In certain embodiments, the second nucleic acid sequence encodes more than one affinity purification tag.

In certain embodiments, the second nucleic acid sequence encodes two affinity purification tags.

In certain embodiments, the encoded affinity purification tag(s) is/are selected from a Streptavidin binding moiety, a maltose binding protein moiety, and a HIS tag.

In certain embodiments the Streptavidin binding moiety is a Nano-tag or a biotinylated Avi-tag.

In certain embodiments, the second nucleic acid sequence encodes no affinity purification tags.

In certain embodiments, the second nucleic acid sequence encodes at least one solubility enhancement tag.

In certain embodiments, the second nucleic acid sequence encodes more than one solubility enhancement tag.

In certain embodiments, the second nucleic acid sequence encodes two solubility enhancement tags.

In certain embodiments, the encoded solubility enhancement tag(s) is/are selected from a maltose binding protein tag, a protein G B1 domain tag, and a myxococcus protein S tag.

In certain embodiments, the second nucleic acid sequence encodes at least one protease recognition site.

In certain embodiments, the protease recognition site(s) is/are a Tobacco Etch Virus (TEV), Thrombin, Factor Xa and/or a HRV 3C protease recognition site.

In certain embodiments, the target protein coding sequence encodes a transcription factor, a transcription factor domain, an epigenetic regulatory factor, or an epigenetic regulatory factor domain.

In certain embodiments, the target protein coding sequence encodes a protein antigen for producing an affinity capture reagent.

In certain embodiments, the affinity capture reagent is an antibody, an antibody fragment, or an aptamer.

In certain embodiments, the target protein coding sequence encodes a protein antigen for producing an antibody or Fab by phage display.

In certain embodiments, the target protein is expressed at about a 1.5 fold higher level than a target protein generated from an expression vector that was not modified as described herein. In certain embodiments, the target protein is expressed at about, e.g., a 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5, or 20, etc., higher level than a target protein generated from an expression vector that was not modified as described herein.

As described herein, in certain embodiments, expression of a target protein from a vector not modified as described herein is undetectable, whereas expression of the same target protein from a vector that has been modified as described herein is detectable.

Certain embodiments of the invention provide a host cell comprising the expression vector as described herein. Host cells are used for the expression of vectors and are known in the art. For example, a host cell may be a bacterial cell, such as E. coli.

Certain embodiments of the invention provide a method for expressing a target protein in a host cell, comprising culturing the host cell as described herein for a period of time under conditions permitting expression of the target protein.

In certain embodiments, the target protein is a protein antigen for producing an affinity capture reagent.

In certain embodiments, the affinity capture reagent is an antibody, an antibody fragment, or an aptamer.

In certain embodiments, the target protein is a protein antigen for producing an antibody or Fab by phage display.

In one aspect, the invention features a method of designing an expression vector for expressing a recombinant protein in a host cell, e.g., bacterial cell (such as E. coli. cell). The method includes steps of: obtaining a first sequence encoding the recombinant protein; obtaining an expression vector containing an insertion site for the first sequence, wherein once inserted at the insertion site, the first sequence is joined in frame with a 5′ sequence from the expression vector to form a first fusion sequence that encodes a RNA sequence, the RNA sequence having a Ribosomal Binding Site (RBS) and a translation initiation site; modifying the RNA sequence by (i) designing the RNA sequence so as to minimize RNA secondary structure in a region around the RBS site or translation initiation site, or (ii) optimizing codon usage in the RNA sequence based on codon usage of the host cell, to obtain a second fusion sequence; and cloning the second fusion sequence into the expression vector in such a way to replace the first fusion sequence.

In one embodiment, the designing step or optimizing step is carried out using Transcript-Optimized Expression Enhancement Technology (TOEET) as shown and described herein. In another, the designing step or optimizing step is carried out by introducing a third sequence encoding a N-terminal polypeptide expression-enhancement tag (EET) directly downstream of the initiation site.

The expression-enhancement tag can be an affinity purification tag, such as one having the sequence of an Avi tag, a Nano-tag, or a 6×His tag.

In a second aspect, the invention provides an expression vector that is designed using the method described above. In the expression vector, the second fusion sequence can have a sequence selected from the sequences shown in FIG. 1. In one example, the expression vector is selected from the group consisting of pNESG_Avi6HT and pNESG_Nano6HT. The invention also provides a host cell having the expression vector.

In a third aspect, the invention features a method for increasing the expression and solubility of a recombinant protein in a host cell. The method includes obtaining the just described host cell; culturing the host cell in a culture for period of time; and recovering the recombinant protein from the host cell or the culture. To that end, the recombinant protein can be a protein antigen for producing an affinity capture reagent (such as an antibody, an antibody fragment, or an aptamer) or a protein antigen for producing antibody or Fab by phage display.

In a fourth aspect, the invention provides an immunogenic composition having the recombinant protein produced by the method described above. The composition can be administered to a subject in need thereof for generating an immune response in the subject.

In a fifth aspect, the invention provides a method of generating an antibody (either polyclonal or monoclonal) by, among others, administrating to a subject the immunogenic composition described above.

The invention also provides an isolated polypeptide, a nucleic acid encoding it, a high throughput method for identifying a soluble protein or protein domain, and a high throughput method for isolating a soluble protein or protein domain substantially as shown and described herein.

The term “nucleic acid” refers to deoxyribonucleotides (DNA, e.g., a cDNA or genomic DNA), ribonucleotides (RNA, e.g., an mRNA), or a DNA or RNA analog and polymers thereof, in either single- or double-stranded form, but preferably is double-stranded DNA, made of monomers (nucleotides) containing a sugar, phosphate and a base that is either a purine or pyrimidine. A DNA or RNA analog can be synthesized from nucleotide analogs. Unless specifically limited, the term encompasses nucleic acids containing known analogs of natural nucleotides that have similar binding properties as the reference nucleic acid and are metabolized in a manner similar to naturally occurring nucleotides. Unless otherwise indicated, a particular nucleic acid sequence also encompasses conservatively modified variants thereof (e.g., degenerate codon substitutions) and complementary sequences, as well as the sequence explicitly indicated. Specifically, degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is substituted with mixed-base and/or deoxyinosine residues.

The term “nucleotide sequence” refers to a polymer of DNA or RNA which can be single-stranded or double-stranded, optionally containing synthetic, non-natural or altered nucleotide bases capable of incorporation into DNA or RNA polymers. The terms “nucleic acid,” “nucleic acid molecule,” or “polynucleotide” are used interchangeably.

Certain embodiments of the invention encompass isolated or substantially purified nucleic acid compositions. An “isolated nucleic acid” is a nucleic acid the structure of which is not identical to that of any naturally occurring nucleic acid or to that of any fragment of a naturally occurring genomic nucleic acid. The term therefore covers, for example, (a) a DNA which has the sequence of part of a naturally occurring genomic DNA molecule but is not flanked by both of the coding sequences that flank that part of the molecule in the genome of the organism in which it naturally occurs; (b) a nucleic acid incorporated into a vector or into the genomic DNA of a prokaryote or eukaryote in a manner such that the resulting molecule is not identical to any naturally occurring vector or genomic DNA; (c) a separate molecule such as a cDNA, a genomic fragment, a fragment produced by polymerase chain reaction (PCR), or a restriction fragment; and (d) a recombinant nucleotide sequence that is part of a hybrid gene, i.e., a gene encoding a fusion protein. Specifically excluded from this definition are nucleic acids present in mixtures of different (i) DNA molecules, (ii) transfected cells, or (iii) cell clones, e.g., as these occur in a DNA library such as a cDNA or genomic DNA library. The nucleic acid described above can be used to express a fusion protein of this invention. For this purpose, one can operatively link the nucleic acid to suitable regulatory sequences to generate an expression vector. The following terms are used to describe the sequence relationships between two or more nucleotide sequences: (a) “reference sequence,” (b) “comparison window,” (c) “sequence identity,” (d) “percentage of sequence identity,” and (e) “substantial identity.”

(a) As used herein, “reference sequence” is a defined sequence used as a basis for sequence comparison. A reference sequence may be a subset or the entirety of a specified sequence; for example, as a segment of a full-length cDNA or gene sequence, or the complete cDNA or gene sequence.

(b) As used herein, “comparison window” makes reference to a contiguous and specified segment of a polynucleotide sequence, wherein the polynucleotide sequence in the comparison window may comprise additions or deletions (i.e., gaps) compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. Generally, the comparison window is at least 20 contiguous nucleotides in length, and optionally can be 30, 40, 50, 100, or longer. Those of skill in the art understand that to avoid a high similarity to a reference sequence due to inclusion of gaps in the polynucleotide sequence a gap penalty is typically introduced and is subtracted from the number of matches.

Methods of alignment of sequences for comparison are well-known in the art. Thus, the determination of percent identity between any two sequences can be accomplished using a mathematical algorithm. Non-limiting examples of such mathematical algorithms are the algorithm of Myers and Miller (Myers and Miller, CABIOS, 4, 11 (1988)); the local homology algorithm of Smith et al. (Smith et al., Adv. Appl. Math., 2, 482 (1981)); the homology alignment algorithm of Needleman and Wunsch (Needleman and Wunsch, JMB, 48, 443 (1970)); the search-for-similarity-method of Pearson and Lipman (Pearson and Lipman, Proc. Natl. Acad. Sci. USA, 85, 2444 (1988)); the algorithm of Karlin and Altschul (Karlin and Altschul, Proc. Natl. Acad. Sci. USA, 87, 2264 (1990)), modified as in Karlin and Altschul (Karlin and Altschul, Proc. Natl. Acad. Sci. USA 90, 5873 (1993)).

Computer implementations of these mathematical algorithms can be utilized for comparison of sequences to determine sequence identity. Such implementations include, but are not limited to: CLUSTAL in the PC/Gene program (available from Intelligenetics, Mountain View, Calif.); the ALIGN program (Version 2.0) and GAP, BESTFIT, BLAST, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Version 8 (available from Genetics Computer Group (GCG), 575 Science Drive, Madison, Wis., USA). Alignments using these programs can be performed using the default parameters. The CLUSTAL program is well described by Higgins et al. (Higgins et al., CABIOS, 5, 151 (1989)); Corpet et al. (Corpet et al., Nucl. Acids Res., 16, 10881 (1988)); Huang et al. (Huang et al., CABIOS, 8, 155 (1992)); and Pearson et al. (Pearson et al., Meth. Mol. Biol., 24, 307 (1994)). The ALIGN program is based on the algorithm of Myers and Miller, supra. The BLAST programs of Altschul et al. (Altschul et al., JMB, 215, 403 (1990)) are based on the algorithm of Karlin and Altschul supra.

Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information. This algorithm involves first identifying high scoring sequence pairs (HSPs) by identifying short words of length W in the query sequence, which either match or satisfy some positive-valued threshold score T when aligned with a word of the same length in a database sequence. T is referred to as the neighborhood word score threshold. These initial neighborhood word hits act as seeds for initiating searches to find longer HSPs containing them. The word hits are then extended in both directions along each sequence for as far as the cumulative alignment score can be increased. Cumulative scores are calculated using, for nucleotide sequences, the parameters M (reward score for a pair of matching residues; always >0) and N (penalty score for mismatching residues; always <0). For amino acid sequences, a scoring matrix is used to calculate the cumulative score. Extension of the word hits in each direction are halted when the cumulative alignment score falls off by the quantity X from its maximum achieved value, the cumulative score goes to zero or below due to the accumulation of one or more negative-scoring residue alignments, or the end of either sequence is reached.

In addition to calculating percent sequence identity, the BLAST algorithm also performs a statistical analysis of the similarity between two sequences. One measure of similarity provided by the BLAST algorithm is the smallest sum probability (P(N)), which provides an indication of the probability by which a match between two nucleotide or amino acid sequences would occur by chance. For example, a test nucleic acid sequence is considered similar to a reference sequence if the smallest sum probability in a comparison of the test nucleic acid sequence to the reference nucleic acid sequence is less than about 0.1, less than about 0.01, or even less than about 0.001.

To obtain gapped alignments for comparison purposes, Gapped BLAST (in BLAST 2.0) can be utilized. Alternatively, PSI-BLAST (in BLAST 2.0) can be used to perform an iterated search that detects distant relationships between molecules. When utilizing BLAST, Gapped BLAST, PSI-BLAST, the default parameters of the respective programs (e.g., BLASTN for nucleotide sequences, BLASTX for proteins) can be used. The BLASTN program (for nucleotide sequences) uses as defaults a wordlength (W) of 11, an expectation (E) of 10, a cutoff of 100, M=5, N=−4, and a comparison of both strands. For amino acid sequences, the BLASTP program uses as defaults a wordlength (W) of 3, an expectation (E) of 10, and the BLOSUM62 scoring matrix. Alignment may also be performed manually by inspection.

For purposes of the present invention, comparison of nucleotide sequences for determination of percent sequence identity to the promoter sequences disclosed herein may be made using the BlastN program (version 1.4.7 or later) with its default parameters or any equivalent program. By “equivalent program” is intended any sequence comparison program that, for any two sequences in question, generates an alignment having identical nucleotide or amino acid residue matches and an identical percent sequence identity when compared to the corresponding alignment generated by the program.

(c) As used herein, “sequence identity” or “identity” in the context of two nucleic acid or polypeptide sequences makes reference to a specified percentage of residues in the two sequences that are the same when aligned for maximum correspondence over a specified comparison window, as measured by sequence comparison algorithms or by visual inspection. When percentage of sequence identity is used in reference to proteins it is recognized that residue positions which are not identical often differ by conservative amino acid substitutions, where amino acid residues are substituted for other amino acid residues with similar chemical properties (e.g., charge or hydrophobicity) and therefore do not change the functional properties of the molecule. When sequences differ in conservative substitutions, the percent sequence identity may be adjusted upwards to correct for the conservative nature of the substitution. Sequences that differ by such conservative substitutions are said to have “sequence similarity” or “similarity.” Means for making this adjustment are well known to those of skill in the art. Typically this involves scoring a conservative substitution as a partial rather than a full mismatch, thereby increasing the percentage sequence identity. Thus, for example, where an identical amino acid is given a score of 1 and a non-conservative substitution is given a score of zero, a conservative substitution is given a score between zero and 1. The scoring of conservative substitutions is calculated, e.g., as implemented in the program PC/GENE (Intelligenetics, Mountain View, Calif.).

(d) As used herein, “percentage of sequence identity” means the value determined by comparing two optimally aligned sequences over a comparison window, wherein the portion of the polynucleotide sequence in the comparison window may comprise additions or deletions (i.e., gaps) as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical nucleic acid base or amino acid residue occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison, and multiplying the result by 100 to yield the percentage of sequence identity.

(e)(i) The term “substantial identity” of polynucleotide sequences means that a polynucleotide comprises a sequence that has at least 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, or 94%, or even at least 95%, 96%, 97%, 98%, or 99% sequence identity, compared to a reference sequence using one of the alignment programs described using standard parameters. One of skill in the art will recognize that these values can be appropriately adjusted to determine corresponding identity of proteins encoded by two nucleotide sequences by taking into account codon degeneracy, amino acid similarity, reading frame positioning, and the like. Substantial identity of amino acid sequences for these purposes normally means sequence identity of at least 70%, 80%, 90%, or even at least 95%.

Another indication that nucleotide sequences are substantially identical is if two molecules hybridize to each other under stringent conditions. Generally, stringent conditions are selected to be about 5° C. lower than the thermal melting point (T_m) for the specific sequence at a defined ionic strength and pH. However, stringent conditions encompass temperatures in the range of about 1° C. to about 20° C., depending upon the desired degree of stringency as otherwise qualified herein. Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides they encode are substantially identical. This may occur, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. One indication that two nucleic acid sequences are substantially identical is when the polypeptide encoded by the first nucleic acid is immunologically cross reactive with the polypeptide encoded by the second nucleic acid.

(e)(ii) The term “substantial identity” in the context of a peptide indicates that a peptide comprises a sequence with at least 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, or 94%, or even 95%, 96%, 97%, 98% or 99%, sequence identity to the reference sequence over a specified comparison window. In certain embodiments, optimal alignment is conducted using the homology alignment algorithm of Needleman and Wunsch (Needleman and Wunsch, JMB, 48, 443 (1970)). An indication that two peptide sequences are substantially identical is that one peptide is immunologically reactive with antibodies raised against the second peptide. Thus, a peptide is substantially identical to a second peptide, for example, where the two peptides differ only by a conservative substitution. Thus, certain embodiments of the invention provide nucleic acid molecules that are substantially identical to the nucleic acid molecules described herein.

For sequence comparison, typically one sequence acts as a reference sequence to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are input into a computer, subsequence coordinates are designated if necessary, and sequence algorithm program parameters are designated. The sequence comparison algorithm then calculates the percent sequence identity for the test sequence(s) relative to the reference sequence, based on the designated program parameters.

As noted above, another indication that two nucleic acid sequences are substantially identical is that the two molecules hybridize to each other under stringent conditions. The phrase “hybridizing specifically to” refers to the binding, duplexing, or hybridizing of a molecule only to a particular nucleotide sequence under stringent conditions when that sequence is present in a complex mixture (e.g., total cellular) DNA or RNA. “Bind(s) substantially” refers to complementary hybridization between a probe nucleic acid and a target nucleic acid and embraces minor mismatches that can be accommodated by reducing the stringency of the hybridization media to achieve the desired detection of the target nucleic acid sequence.

“Stringent hybridization conditions” and “stringent hybridization wash conditions” in the context of nucleic acid hybridization experiments such as Southern and Northern hybridizations are sequence dependent, and are different under different environmental parameters. Longer sequences hybridize specifically at higher temperatures. The thermal melting point (Tm) is the temperature (under defined ionic strength and pH) at which 50% of the target sequence hybridizes to a perfectly matched probe. Specificity is typically the function of post-hybridization washes, the critical factors being the ionic strength and temperature of the final wash solution. For DNA-DNA hybrids, the T_mcan be approximated from the equation of Meinkoth and Wahl (1984); T_m81.5° C.+16.6 (log M)+0.41 (% GC)−0.61 (% form)−500/L; where M is the molarity of monovalent cations, % GC is the percentage of guanosine and cytosine nucleotides in the DNA, % form is the percentage of formamide in the hybridization solution, and L is the length of the hybrid in base pairs. T_mis reduced by about 1° C. for each 1% of mismatching; thus, T_m, hybridization, and/or wash conditions can be adjusted to hybridize to sequences of the desired identity. For example, if sequences with >90% identity are sought, the T_mcan be decreased 10° C. Generally, stringent conditions are selected to be about 5° C. lower than the T_mfor the specific sequence and its complement at a defined ionic strength and pH. However, severely stringent conditions can utilize a hybridization and/or wash at 1, 2, 3, or 4° C. lower than the T_m; moderately stringent conditions can utilize a hybridization and/or wash at 6, 7, 8, 9, or 10° C. lower than the T_m; low stringency conditions can utilize a hybridization and/or wash at 11, 12, 13, 14, 15, or 20° C. lower than the T_m. Using the equation, hybridization and wash compositions, and desired temperature, those of ordinary skill will understand that variations in the stringency of hybridization and/or wash solutions are inherently described. If the desired degree of mismatching results in a temperature of less than 45° C. (aqueous solution) or 32° C. (formamide solution), the SSC concentration is increased so that a higher temperature can be used. Generally, highly stringent hybridization and wash conditions are selected to be about 5° C. lower than the T_mfor the specific sequence at a defined ionic strength and pH.

An example of highly stringent wash conditions is 0.15 M NaCl at 72° C. for about 15 minutes. An example of stringent wash conditions is a 0.2×SSC wash at 65° C. for 15 minutes. Often, a high stringency wash is preceded by a low stringency wash to remove background probe signal. An example medium stringency wash for a duplex of, e.g., more than 100 nucleotides, is 1×SSC at 45° C. for 15 minutes. For short nucleotide sequences (e.g., about 10 to 50 nucleotides), stringent conditions typically involve salt concentrations of less than about 1.5 M, less than about 0.01 to 1.0 M, Na ion concentration (or other salts) at pH 7.0 to 8.3, and the temperature is typically at least about 30° C. and at least about 60° C. for long probes (e.g., >50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide. In general, a signal to noise ratio of 2× (or higher) than that observed for an unrelated probe in the particular hybridization assay indicates detection of a specific hybridization. Nucleic acids that do not hybridize to each other under stringent conditions are still substantially identical if the proteins that they encode are substantially identical. This occurs, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code.

Very stringent conditions are selected to be equal to the T_mfor a particular probe. An example of stringent conditions for hybridization of complementary nucleic acids that have more than 100 complementary residues on a filter in a Southern or Northern blot is 50% formamide, e.g., hybridization in 50% formamide, 1 M NaCl, 1% SDS at 37° C., and a wash in 0.1×SSC at 60 to 65° C. Exemplary low stringency conditions include hybridization with a buffer solution of 30 to 35% formamide, 1 M NaCl, 1% SDS (sodium dodecyl sulphate) at 37° C., and a wash in 1× to 2×SSC (20×SSC=3.0 M NaCl/0.3 M trisodium citrate) at 50 to 55° C. Exemplary moderate stringency conditions include hybridization in 40 to 45% formamide, 1.0 M NaCl, 1% SDS at 37° C., and a wash in 0.5× to 1×SSC at 55 to 60° C.

In addition to the chemical optimization of stringency conditions, analytical models and algorithms can be applied to hybridization data-sets (e.g. microarray data) to improve stringency.

An expression vector as described herein can be introduced into host cells to produce a fusion protein of this invention. Also within the scope of this invention is a host cell that contains the above-described nucleic acid. Examples include E. coli cells, insect cells (e.g., using baculovirus expression vectors), yeast cells, plant cells, or mammalian cells. See e.g., Goeddel, (1990) Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. To produce a fusion protein of this invention, one can culture a host cell in a medium under conditions permitting expression of the protein encoded by a nucleic acid of this invention, and isolate the protein from the cultured cell or the medium of the cell. The presence of the fusion protein in an occlusion body allows one to prepare the protein from the host cell by simply separating the occlusion body from the host cell. Alternatively, the nucleic acid of this invention can be transcribed and translated in vitro, for example, using T7 promoter regulatory sequences and T7 polymerase.

The terms “peptide,” “polypeptide,” and “protein” are used herein interchangeably to describe the arrangement of amino acid residues in a polymer. A peptide, polypeptide, or protein can be composed of the standard 20 naturally occurring amino acid, in addition to rare amino acids and synthetic amino acid analogs. They can be any chain of amino acids, regardless of length or post-translational modification (for example, glycosylation or phosphorylation). The peptide, polypeptide, or protein “of this invention” includes recombinantly or synthetically produced fusion versions having the particular domains or portions that are soluble. The term also encompasses polypeptides that have an added amino-terminal methionine (useful for expression in prokaryotic cells).

A “recombinant” peptide, polypeptide, or protein refers to a peptide, polypeptide, or protein produced by recombinant DNA techniques; i.e., produced from cells transformed by an exogenous DNA construct encoding the desired peptide. A “synthetic” peptide, polypeptide, or protein refers to a peptide, polypeptide, or protein prepared by chemical synthesis. The term “recombinant” when used with reference, e.g., to a cell, or nucleic acid, protein, or vector, indicates that the cell, nucleic acid, protein or vector, has been modified by the introduction of a heterologous nucleic acid or protein or the alteration of a native nucleic acid or protein, or that the cell is derived from a cell so modified.

Within the scope of this invention are fusion proteins containing one or more of the afore-mentioned sequences and a heterologous sequence. A heterologous polypeptide, nucleic acid, or gene is one that originates from a foreign species, or, if from the same species, is substantially modified from its original form. Two fused domains or sequences are heterologous to each other if they are not adjacent to each other in a naturally occurring protein or nucleic acid.

An “isolated” peptide, polypeptide, or protein refers to a peptide, polypeptide, or protein that has been separated from other proteins, lipids, and nucleic acids with which it is naturally associated. The polypeptide/protein can constitute at least 10% (i.e., any percentage between 10% and 100%, e.g., 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 90%, 95%, and 99%) by dry weight of the purified preparation. Purity can be measured by any appropriate standard method, for example, by column chromatography, polyacrylamide gel electrophoresis, or HPLC analysis. An isolated polypeptide/protein described in the invention can be purified from a natural source, produced by recombinant DNA techniques, or by chemical methods.

A functional equivalent of a peptide, polypeptide, or protein of this invention refers to a polypeptide derivative of the peptide, polypeptide, or protein, e.g., a protein having one or more point mutations, insertions, deletions, truncations, a fusion protein, or a combination thereof. It retains substantially the activity of the corresponding unmodified peptide/polypeptide/protein (e.g., the activity of transcription factor). The isolated polypeptide can contain a sequence of a protein as listed in Table 1 or 2 or a functional fragment thereof. In general, the functional equivalent is at least 75% (e.g., any number between 75% and 100%, inclusive, e.g., 70%, 80%, 85%, 90%, 95%, and 99%) identical to the corresponding unmodified peptide/polypeptide/protein.

The amino acid composition of the above-mentioned peptide/polypeptide/protein may vary without disrupting their biological activity, e.g., a transcription factor activity, i.e., ability to bind to a DNA element and/or trigger or inhibit the respective cellular response. For example, it can contain one or more conservative amino acid substitutions. A “conservative amino acid substitution” is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), β-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in a polypeptide is preferably replaced with another amino acid residue from the same side chain family. Alternatively, mutations can be introduced randomly along all or part of the sequences, such as by saturation mutagenesis, and the resultant mutants can be screened for the respective biological activities.

A polypeptide described in this invention can be obtained as a recombinant polypeptide. To prepare a recombinant polypeptide, a nucleic acid encoding it can be linked to another nucleic acid encoding a fusion partner, e.g., the tags disclosed herein, glutathione-s-transferase (GST), 6×-His epitope tag (or Hexa-His), 8×-His (or Octa-His) epitope tag, or M13 Gene 3 protein. The resultant fusion nucleic acid expresses in suitable host cells a fusion protein that can be isolated by methods known in the art. The isolated fusion protein can be further treated, e.g., by enzymatic digestion (e.g., TEV protease digestion), to remove the fusion partner and obtain the recombinant polypeptide of this invention.

The peptide/polypeptide/protein of this invention covers chemically modified versions. Examples of chemically modified peptide/protein include those subjected to conformational change, addition or deletion of a sugar chain, and those to which a compound such as polyethylene glycol has been bound. Once purified and tested by standard methods or according to the methods described in the examples below, the peptide/polypeptide/protein can be included in a composition, e.g., a pharmaceutical composition or an immunogenic composition.

The term “immunogenic” refers to a capability of producing an immune response in a host animal against an antigen or antigens. This immune response forms the basis of the protective immunity elicited by a vaccine against a specific infectious organism. “Immune response” refers to a response elicited in an animal, which may refer to cellular immunity (CMI); humoral immunity or both. “Antigenic agent,” “antigen,” or “immunogen” means a substance that induces a specific immune response in a host animal. The antigen can be a protein described above, a vector encoding it, a cell having the vector or protein, or any combination thereof.

The term “animal” includes all vertebrate animals including humans. It also includes an individual animal in all stages of development, including embryonic and fetal stages. In particular, the term “vertebrate animal” includes, but not limited to, humans, canines (e.g., dogs), felines (e.g., cats); equines (e.g., horses), bovines (e.g., cattle), porcine (e.g., pigs), as well as in avians. The term “avian” refers to any species or subspecies of the taxonomic class ava, such as, but not limited to, chickens (breeders, broilers and layers), turkeys, ducks, a goose, a quail, pheasants, parrots, finches, hawks, crows and ratites including ostrich, emu and cassowary.

The immunogenic composition can be used to generate antibodies against the peptide/polypeptide/protein of this invention. As used herein, “antibody” is used in the broadest sense and specifically covers monoclonal antibodies (including full length monoclonal antibodies), polyclonal antibodies, multispecific antibodies (e.g., bispecific antibodies), and antibody fragments so long as they exhibit the desired biological activity.

As used herein, “antibody fragments”, may comprise a portion of an intact antibody, generally including the antigen binding or variable region of the intact antibody, the Fab region of the antibody, or the Fc region of an antibody which retains FcR binding capability. Examples of antibody fragments include linear antibodies; single-chain antibody molecules; and multispecific antibodies formed from antibody fragments. The antibody fragments preferably retain at least part of the hinge and optionally the CH1 region of an IgG heavy chain. More preferably, the antibody fragments retain the entire constant region of an IgG heavy chain, and include an IgG light chain.

As used herein, Affinity Capture Reagents are cognate molecules capable or recognizing and binding to a protein antigen, including protein antigens produced by TOEET-optimized expression vectors. Affinity Capture reagents include (but are not limited to) monoclonal and polyclonal antibodies, Fab or Fab fragments generated by phage and related antigen display methods, RNA aptamers, and various protein binding scaffolds which can be used to generate antigen-recognizing molecules.

As used herein, the term “Fc fragment” or “Fc region” is used to define a C-terminal region of an immunoglobulin heavy chain. The “Fc region” may be a native sequence Fc region or a variant Fc region. Although the boundaries of the Fc region of an immunoglobulin heavy chain might vary, the human IgG heavy chain Fc region is usually defined to stretch from an amino acid residue at position Cys226, or from Pro230, to the carboxyl-terminus thereof.

A “native sequence Fc region” comprises an amino acid sequence identical to the amino acid sequence of an Fc region found in nature. A “variant Fc region” as appreciated by one of ordinary skill in the art comprises an amino acid sequence which differs from that of a native sequence Fc region by virtue of at least one “amino acid modification.” Preferably, the variant Fc region has at least one amino acid substitution compared to a native sequence Fc region or to the Fc region of a parent polypeptide, e.g., from about one to about ten amino acid substitutions, and preferably from about one to about five amino acid substitutions in a native sequence Fc region or in the Fc region of the parent polypeptide. The variant Fc region herein will preferably possess at least about 80% homology with a native sequence Fc region and/or with an Fc region of a parent polypeptide, and more preferably at least about 90% homology therewith, more preferably at least about 95% homology therewith, even more preferably, at least about 99% homology therewith.

Within the scope of this invention is a composition that contains a suitable carrier and one or more of the agents described above. The composition can be a pharmaceutical composition that contains a pharmaceutically acceptable carrier. The term “pharmaceutical composition” refers to the combination of an active agent with a carrier, inert or active, making the composition especially suitable for diagnostic or therapeutic use in vivo or ex vivo. A “pharmaceutically acceptable carrier,” after administered to or upon a subject, does not cause undesirable physiological effects. The carrier in the pharmaceutical composition must be “acceptable” also in the sense that it is compatible with the active ingredient and can be capable of stabilizing it. One or more solubilizing agents can be utilized as pharmaceutical carriers for delivery of an active compound. Examples of a pharmaceutically acceptable carrier include, but are not limited to, biocompatible vehicles, adjuvants, additives, and diluents to achieve a composition usable as a dosage form. Examples of other carriers include colloidal silicon oxide, magnesium stearate, cellulose, and sodium lauryl sulfate.

As used herein, a “subject” refers to a human and a non-human animal. Examples of a non-human animal include all vertebrates, e.g., mammals, such as non-human mammals, non-human primates (particularly higher primates), dog, rodent (e.g., mouse or rat), guinea pig, cat, and rabbit, and non-mammals, such as birds, amphibians, reptiles, etc. In one embodiment, the subject is a human. In another embodiment, the subject is an experimental, non-human animal or animal suitable as a disease model.

The composition of this invention can include an adjuvant agent or adjuvant. As used herein, the term “adjuvant agent” or “adjuvant” means a substance added to an immunogenic composition or a vaccine to increase the immunogenic composition or the vaccine's immunogenicity. Examples of an adjuvant include a cholera toxin, Escherichia coli heat-labile enterotoxin, liposome, unmethylated DNA (CpG) or any other innate immune-stimulating complex. Various adjuvants that can be used to further increase the immunological response depend on the host species and include Freund's adjuvant (complete and incomplete), mineral gels such as aluminum hydroxide, surface-active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol. Useful human adjuvants include BCG (bacille Calmette-Guerin) and Corynebacterium parvum.

Pharmaceutical compositions comprising an adjuvant and an antigen may be manufactured by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes. Pharmaceutical compositions may be formulated in conventional manner using one or more physiologically acceptable carriers, diluents, excipients or auxiliaries which facilitate processing of the antigens of the invention into preparations which can be used pharmaceutically. Proper formulation is dependent upon the route of administration chosen.

A pharmaceutical composition of this invention can be administered parenterally, orally, nasally, rectally, topically, or buccally. The term “parenteral” as used herein refers to subcutaneous, intracutaneous, intravenous, intramuscular, intraarticular, intraarterial, intrasynovial, infrasternal, intrathecal, intralesional, or intracranial injection, as well as any suitable infusion technique. For injection, immunogenic or vaccine preparations may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks's solution, Ringer's solution, phosphate buffered saline, or any other physiological saline buffer. The solution may contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the peptides, polypeptides, or proteins may be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.

Determination of an effective amount of the immunogenic or vaccine formulation for administration is well within the capabilities of those skilled in the art, especially in light of the detailed disclosure provided herein. An effective dose can be estimated initially from in vitro assays. For example, a dose can be formulated in animal models to achieve an induction of an immune response using techniques that are well known in the art. One having ordinary skill in the art could readily optimize administration to all animal species based on results described herein. Dosage amount and interval may be adjusted individually. For example, when used as a vaccine, the vaccine formulations of the invention may be administered in about 1 to 3 doses for a 1-36 week period. Preferably, 1 or 2 doses are administered, at intervals of about 3 weeks to about 4 months, and booster vaccinations may be given periodically thereafter. Alternative protocols may be appropriate for individual animals. A suitable dose is an amount of the vaccine formulation that, when administered as described above, is capable of raising an immune response in an immunized animal sufficient to protect the animal from an infection for at least 4 to 12 months. In general, the amount of the antigen present in a dose ranges from about 1 pg to about 100 mg per kg of host, typically from about 10 pg to about 1 mg, and preferably from about 100 pg to about 1 pg. Suitable dose range will vary with the route of injection and the size of the patient, but will typically range from about 0.1 ml to about 5 ml.

This invention also provides methods for making antibodies against the above-described proteins. The antibodies can be either polyclonal or monoclonal.

Polyclonal antibodies against a protein of the invention can be obtained as follows. After verifying that a desired serum antibody level has been reached, blood is withdrawn from the mammal sensitized with the antigen. Serum is isolated from this blood using well-known methods. The serum containing the polyclonal antibody may be used as the polyclonal antibody, or according to needs, the polyclonal antibody-containing fraction may be further isolated from the serum. For instance, a fraction of antibodies that specifically recognize the protein of the invention may be prepared by using an affinity column to which the protein is coupled. Then, the fraction may be further purified by using a Protein A or Protein G column in order to prepare immunoglobulin G or immunoglobulin M.

To obtain monoclonal antibodies, after verifying that the desired serum antibody level has been reached in the mammal sensitized with the above-described antigen, immunocytes are taken from the mammal and used for cell fusion. For this purpose, splenocytes can be preferable immunocytes. As parent cells fused with the above immunocytes, mammalian myeloma cells are preferably used. More preferably, myeloma cells that have acquired the feature, which can be used to distinguish fusion cells by agents, are used as the parent cell.

The cell fusion between the above immunocytes and myeloma cells can be conducted according to known methods, for example, the method of Milstein et al. (Methods Enzymol., 73:3-46, 1981). The hybridoma obtained from cell fusion is selected by culturing the cells in a standard selective culture medium, for example, HAT culture medium (hypoxanthine, aminopterin, thymidine-containing culture medium). The culture in this HAT medium is continued for a period sufficient enough for cells (non-fusion cells) other than the objective hybridoma to perish, usually from a few days to a few weeks. Next, the usual limiting dilution method is carried out, and the hybridoma producing the objective antibody is screened and cloned.

Other than the above method for obtaining hybridomas, by immunizing an animal other than humans with the antigen, a hybridoma producing the objective human antibodies having the activity to bind to proteins can be obtained by the method of sensitizing human lymphocytes, for example, human lymphocytes infected with the EB virus, with proteins, protein-expressing cells, or lysates thereof in vitro, fusing the sensitized lymphocytes with myeloma cells derived from human having a permanent cell division ability.

The obtained monoclonal antibodies can be purified by, for example, ammonium sulfate precipitation, protein A or protein G column, DEAE ion exchange chromatography, an affinity column to which the protein of the present invention is coupled, and so on. The antibody may be useful for the purification or detection of a protein of the invention. It may also be a candidate for an agonist or antagonist of the protein. Furthermore, it is possible to use it for the antibody treatment of diseases in which the protein is implicated. For in vivo administration (in such antibody treatment), human antibodies or humanized antibodies may be favorably used because of their reduced antigenicity.

For example, a human antibody against a protein can be obtained using hybridomas made by fusing myeloma cells with antibody-producing cells obtained by immunizing a transgenic animal comprising a repertoire of human antibody genes with an antigen such as a protein, protein-expressing cells, or a cell lysate thereof. Other than producing antibodies by using hybridoma, antibody—producing immunocytes, such as sensitized lymphocytes that are immortalized by oncogenes, may also be used.

Such monoclonal antibodies can also be obtained as recombinant antibodies produced by using the genetic engineering technique. Recombinant antibodies are produced by cloning the encoding DNA from immunocytes, such as hybridoma or antibody-producing sensitized lymphocytes, incorporating this into a suitable vector, and introducing this vector into a host to produce the antibody. The present invention encompasses such recombinant antibodies as well.

Moreover, the antibody of the present invention may be an antibody fragment or a modified-antibody, so long as it binds to a protein of the invention. For example, Fab, F (ab′)₂, Fv, or single chain Fv in which the H chain Fv and the L chain Fv are suitably linked by a linker (scFv, Huston et al., Proc. Natl. Acad. Sci. USA, 85:5879-5883, 1988) can be given as antibody fragments. Specifically, antibody fragments are produced by treating antibodies with enzymes, for example, papain, pepsin, and such, or by constructing a gene encoding an antibody fragment, introducing this into an expression vector, and expressing this vector in suitable host cells (for example, Co et al., J. Immunol., 152:2968-2976, 1994; Better et al., Methods Enzymol., 178:476-496, 1989; Pluckthun et al., Methods Enzymol., 178:497-515, 1989; Lamoyi, Methods Enzymol., 121:652-663, 1986; Rousseaux et al., Methods Enzymol., 121:663-669, 1986; Bird et al., Trends Biotechnol., 9:132-137, 1991).

As modified antibodies, antibodies bound to various molecules such as polyethylene glycol (PEG) can be used. The antibody of the present invention encompasses such modified antibodies as well. To obtain such a modified antibody, chemical modifications are done to the obtained antibody. These methods are already established in the field.

The antibody of the invention may be obtained as a chimeric antibody, comprising non-human antibody-derived variable region and human antibody-derived constant region, or as a humanized antibody comprising non-human antibody-derived complementarity determining region (CDR), human antibody-derived framework region (FR), and human antibody-derived constant region by using conventional methods.

Antibodies thus obtained can be purified to uniformity. The separation and purification methods used in the present invention for separating and purifying the antibody may be any method usually used for proteins. For instance, column chromatography, such as affmity chromatography, filter, ultrafiltration, salt precipitation, dialysis, SDS-polyacrylamide gel electrophoresis, isoelectric point electrophoresis, and so on, may be appropriately selected and combined to isolate and purify the antibodies (Antibodies: a laboratory manual. Ed Harlow and David Lane, Cold Spring Harbor Laboratory, 1988), but is not limited thereto. Antibody concentration of the above mentioned antibody can be assayed by measuring the absorbance, or by the enzyme-linked immunosorbent assay (ELISA), etc. Protein A or Protein G column can be used for the affmity chromatography. Protein A column may be, for example, Hyper D, POROS, Sepharose F.F., and so on.

Other chromatography may also be used, such as ion exchange chromatography, hydrophobic chromatography, gel filtration, reverse phase chromatography, and adsorption chromatography (Strategies for Protein Purification and Characterization: A laboratory Course Manual. Ed. by Marshak D.R. et al., Cold Spring Harbor Laboratory Press, 1996). These may be performed on liquid chromatography such as HPLC or FPLC.

Examples of methods that assay the antigen-binding activity of the antibodies of the invention include, for example, measurement of absorbance, enzyme-linked immunosorbent assay (ELISA), enzyme immunoassay (EIA), radio immunoassay (RIA), or fluorescent antibody method. For example, when using ELISA, a protein of the invention is added to a plate coated with the antibodies of the invention, and next, the objective antibody sample, for example, culture supernatants of antibody-producing cells, or purified antibodies are added. Then, secondary antibody recognizing the antibody, which is labeled by alkaline phosphatase and such enzymes, is added, the plate is incubated and washed, and the absorbance is measured to evaluate the antigen-binding activity after adding an enzyme substrate such as p-nitrophenyl phosphate. As the protein, a protein fragment, for example, a fragment comprising a C-terminus, or a fragment comprising an N-terminus may be used. To evaluate the activity of the antibody of the invention, BIAcore may be used.

The following non-limiting examples set forth herein below illustrate certain aspects of the invention.

Example 1

This example describes two specific EET tags designed utilizing TOEET. These EETs were engineered and subcloned into the pET15_NESG expression vector (Acton et al., 2011). They contain dual tandem protein purification tags and a protease cleavage site to facilitate purification of the resulting proteins. These include the 6×-His tag (Crowe et al., 1994), and one of two Streptavidin binding moieties, either the Avi-tag (Scholle et al., 2004) or the Nano-tag (Lamla and Erdmann, 2004). The Nano-tag binds directly to streptavidin (Lamla and Erdmann, 2004); the Avi-tag is a substrate for the enzyme BirA which can be used to catalyze the covalent attachment of biotin to the Avi Tag (Scholle et al., 2004). These tandem tags allow for two separate affinity purification steps, (i) Ni-based immobilized metal affinity chromatography (IMAC) and (ii) high-affinity Streptavidin-based chromatography. This dual purification strategy allows preparation of highly purified proteins using high-throughput affinity purification methods. The Tobacco Etch Virus (TEV) protease recognition site (Kapust et al., 2002) engineered into these EETs allows removal of the affinity tags, if required, after expression and purification of the protein target.

Briefly, in designing the DNA sequences coding for these EETs, the coding sequence of one of the two Streptavidin binding moieties i.e., Avi-tag (SEQ ID NO:1—MSGLNDIFEAQKIEWHE) or Nano-tag (SEQ ID NO:2—MDVEAWLDERVPLVET) (Lamla and Erdmann, 2004; Scholle et al., 2004), a 6×-His tag (Crowe et al., 1994), and a TEV protease recognition site (Kapust et al., 2002) were fused in frame and optimized to have a high Codon Adaptation Index (Sharp and Li, 1987) (FIG. 1). The DNA sequence coding for the EET was optimized with TOEET, together with the 5′-untranslated region of the pET15-NESG expression vector, to generate the expression vectors pNESG_Avi6HT and pNESG_Nano6HT, shown in FIG. 1. These features functioned together to enhance translation initiation and protein expression levels.

Using these expression vectors (FIG. 1), protein expression resulted in T7 RNA Polymerase mediated transcription producing an mRNA transcript consisting of (i) vector sequence (pET15_NESG-5′-untranslated region), (ii) nucleotides coding for the EET, and (iii) nucleotides coding for the target protein sequence. Both the untranslated region of the vector upstream of the EET-coding region, and the RNA coding for the EET itself were optimized to avoid secondary structure formation within and between these regions of the mRNA transcript. In this particular implementation, the length of the optimized nucleotide sequence coding for the EET was about 90 nucleotides. Together with the 70 upstream 5′-untranslated nucleotides of the transcript driven by the T7 promoter of the vector, the 5′-region of the transcript was optimized as a unit of about 160 nucleotides. Longer optimized nucleotide sequences, and potentially somewhat shorter optimized nucleotide sequences may also be effective in creating TOEET-based expression-enhanced vectors.

The optimized regions of the pNESG_Avi6HT and pNESG_Nano6HT based TOEET vectors are shown in FIG. 1. The figure shows the DNA sequences, RNA sequences, and the translated protein tag (SEQ ID NO:3—MSGLNDIFEAQKIEWHEHHHHHHENLYFQSH and SEQ ID NO:4—MDVEAWLDERVPLVETHHHHHHENLYFQSH, respectively) sequences of the expression vectors, along with the DNA sequence coding for the multiple cloning site (MCS), a series of restriction endonuclease sites used for cloning into the expression plasmids. FIG. 2 shows, as an example, the predicted RNA secondary structure in transcripts generated from the pNESG_Avi6HT vector, highlighting the lack of predicted RNA secondary structure near the RBS/translation initiation site.

A third vector comprising the Pyrococcus furiosus (PfR) Maltose Binding Protein (MBP) was also constructed and optimized using TOEET. The MBP from Pyrococcus furiosus is much more thermally stable than that of E. coli, and is expected to provide a more robust solubilization enhancement tag and affinity purification tag. Proteins that are expressed but not soluble in cell extracts can be solubilized and used successfully as antigens using various methods of solublization, including urea and guanidine denaturtants (Agaton et al, 2003). The PfR MBP provides improved purification of target proteins under such partially denaturing conditions or other harsh conditions. The sequences shown at the top of FIG. 4 correspond to the first 30 residues of the wild-type PfR-MBP DNA sequence lacking the native secretion signal. The protein open reading frame (DNA sequence) is shown above the corresponding protein sequence and directly below is the T7 RNA polymerase mediated RNA transcript resulting from the cloning of the PfR-MBP into the pET15_NESG backbone. The lower set of sequences shown in FIG. 4 correspond to TOEET optimized PfR-MBP. Silent mutations were introduced for codon optimization or to decrease the predicted RNA secondary structure in the regions of the RBS and translation initiation codon, or both. The silent mutations were introduced using primers incorporating the nucleotide changes and 5 successive rounds of PCR, negating the need for expensive total gene synthesis.

The predicted mRNA secondary structure resulting from T7-RNA Polymerase based transcription off of the pET15_NESG vector backbone with Pyrococcus furiosus (PfR) Maltose Binding Protein (MBP) without TOEET optimization is shown in FIG. 5. Significant secondary structure (base pairing) at both the Ribosome Binding Site (RBS) and the translation initiation site (Initiation Codon) is predicted. The predicted mRNA secondary structure resulting from T7-RNA Polymerase based transcription off of the pET15_NESG vector backbone with Pyrococcus furiosus (PfR) Maltose Binding Protein (MBP) after TOEET optimization is shown in FIG. 6. As illustrated by FIG. 6, significantly greater open structure (lack of base pairing) after TOEET optimization is predicted.

Example 2

The results obtained from expression studies with the above-described new vectors demonstrated that the TOEET strategy is both extremely successful and robust. In this example, similar expression and solubility studies were carried out using a high throughput methodology for the identification and isolation of soluble proteins and protein domains.

As mentioned above, the isolation of soluble, well-folded proteins and protein domains is of great use and importance to the biotechnology industry and biological researchers as a whole. However, the production of such protein reagents remains extremely challenging, especially in the cost effective, commonly used bacterial expression systems. These Escherichia coli expression systems are often successful in the production of simple bacterial proteins but are far less amenable to the production of eukaryotic, mulitdomain proteins or protein complexes, often resulting in no or low levels of expression and/or solubility (greatly complicating or thwarting their production as a protein reagent). There are a variety of reasons that contribute to the lower success rate of these proteins in bacterial expression systems including the fact that eukaryotic proteins are frequently multidomain in nature, this often results in misfolding when expressed using simple prokaryotic expression systems (Netzer and Hartl, 1997). Another major reason for the higher attrition rate relates to the increased levels of disordered regions in human and other eukaryotic proteins in comparison to simpler organisms (Lui et al., 2002). These disordered regions likely cause aggregation and misfolding in E. coli expression systems leading to proteins or domains with low expression and/or solubility, again, greatly interfering with their production.

To circumvent these issues, the NESG Construct Optimization Software and High ThroughPut (HTP) Molecular Cloning and Expression Screening Platform and Automated Purification Pipeline methods were developed for assaying multiple alternative constructs to identify soluble proteins or domains (Methods in Enzymology, Vol. 493, Burlington: Academic Press, 2011, pp. 21-60.). Briefly, the NESG Construct Optimization Software used reports from the from the DisMeta Server (http://www-nmr.cabm.rutgers.edu/bioinformatics/disorder), a metaserver that generated a consensus analysis of eight sequence-based disorder predictors to identify protein regions that are likely to be disordered. In addition, secondary structure, transmembrane and signal peptides among others were also predicted. This data along with multiple sequence alignments of homologous proteins were used to predict possible structural domain boundaries. Based on this information, the NESG Construct Optimization software generated nested sets of alternative constructs, for full-length proteins, multidomain constructs, and single domain constructs. Primers for cloning were then designed using the software Primer Primer (Everett, J.K.; Acton, T.B.; Montelione, G.T.J. Struct. Funct. Genomics 2004, 5: 13-21. Primer Prim′r: A web based server for automated primer design.). Thus for a single targeted region, multiple open reading frames were generally designed varying the N and/or C-terminal sequences. These alternative constructs often possessed significantly better expression, solubility and biophysical behavior than their full-length parent sequences, increasing the possibility of successfully producing a protein reagent.

Although the NESG Construct Optimization Software identified protein subsequences that were more likely to produce soluble well-behaved samples, several variants of each were assayed to identify constructs amenable to protein sample production. Therefore the high-throughput NESG Molecular Cloning and Expression Screening Platform was developed utilizing 96-well parallel cloning/E. coli expression and Qiagen BioRobotS000-based liquid handling. Briefly, protein target sequences (constructs) were PCR amplified from Reverse Transcriptase (RT) generated cDNA pools or genomic DNA, gel purified and extracted in 96-well format (robotic liquid handling) and subcloned into pET_NESG, a series of T7 based (Novagen) bacterial expression vectors generated at Rutgers, using InFusion (Clonetech) Ligation Independent Cloning (LIC). The RT generated cDNA pools were derived from normal and disease tissue (tumor cells and cell lines) allowing for the isolation of wild-type and polymorphic proteins. Correct clones (containing the desired protein open reading frame) were identified using plate based-PCR assays. An automated DNA Miniprep Protocol isolated the nascent expression vectors and a 96-well transformation protocol was used to introduce the plasmids into the BI21(DE3) pMgK E. coli expression strain. Following overnight growth, a single representative colony from each well (96) was transferred to LB in a 96-well S-Block and incubated for 6 hours. Automated liquid handling was then utilized to produce a 500 microliter overnight subculture of each of the 96 constructs in a single 96-well S-block. An aliquot of each well was then subcultured into the corresponding well of one of four 24-well blocks containing 2 ml of fresh media and incubated at 37° C. until mid-log phase growth. Protein expression is induced with IPTG (Isopropyl13-D-1-thiogalactopyranoside) and incubated overnight at 17° C. The cells were harvested using automated liquid handling and sonicated in 96-well format. The expression and solubility of each construct was visualized by SDS-PAGE analysis and constructs suitable for protein production were identified.

The soluble expression constructs were then fermented in large volume using parallel fermentation system, consisting of 2.5-L baffled Ultra Yield™ Fembach flasks, low-cost platform shakers, controlled temperature rooms and specialized MJ9 media (Jansson et al. 1996). This generally produced 10-100 mg of protein per liter of culture. The resulting proteins were then purified using high-throughput AKTAxpress-based parallel protein purification system. This consisted of a two-step automated Ni-affinity purification (pET_NESG imparts a 6×-His tag) followed by gel filtration chromatography. The purified proteins were then analyzed for quality including molecular weight validation by MALDI-TOF mass spectrometry, homogeneity analysis by SDS-PAGE, aggregation screening by analytical gel filtration with static light scattering, and finally concentration determination was performed.

Together the NESG Construct Optimization Software, Molecular Cloning and Expression Screening Platform and Automated Purification Pipeline allow for identification and isolation of large numbers of soluble well-behaved protein reagents in a time efficient and cost effective manner. Without this technology, many of the proteins would prove elusive in regard to production as a protein reagent.

In this process, target protein expression constructs were designed using proprietary bioinformatics methods, cloning was done using robotic methods and protocols, and Expression (E, ranging from 0 to 5) and Solubility (S, ranging from 0 to 5) screening were performed in a high throughput fashion and assessed using SDS-PAGE analysis. The read out (ES score=E score×S score, ranging from 0 to 25) provided a measure of the usability of a particular target construct and expression vector system combination for large-scale protein sample production. In general, constructs providing ES scores≧9 in this high throughout expression and solubility assay provided milligram-per-liter (or tens-of-milligram per liter) quantities of protein samples in medium scale (0.5-3 L) shake flask fermentations.

As a demonstration of the TOEET technology, a set of approximately 96 human transcription factor genes and epigenetic regulatory factor genes were cloned into the pET15_NESG vector (Acton et al., 2011) lacking a TOEET sequence, and into both the pNESG_Avi6HT and pNESG_Nano6HT vectors. These expression vectors were constructed, and the expression and solubility of target proteins assessed, using the technology outlined above. The results of this study are summarized in Table 1.

It was found that, using the pET15_NESG vector, only 20 of 99 constructs provided expression and solubility levels that can support scale-up protein sample production (ES score≧9; highlighted in grey shade in Table 1). In contrast, using the pNESG_Nano6HT or pNESG_Avi6HT on this same set of target genes provided a significant increase in the number of highly-expressed and soluble targets suitable for scale-up production. As shown in Table 1, 42 of 98 tested, and 34 of 94 tested protein targets exhibited an ES score≧9 (highlighted in grey shade in Table 1) in the pNESG_Avi6HT and pNESG_Nano6HT vectors, respectively. Several SDS-PAGE gels illustrating these expression and solubility enhancements are shown in FIG. 3. Not only were more of these 99 human protein target genes expressed using TOEET, but both expression levels and solubility were generally increased. For example, while about half of the 99 protein targets had expression value E=0 (i.e. no detectable expression) in the pET15_NESG vector (lacking TOEET), 95 of the 99 protein targets had expression values E≧2 in either the pNESG_Nano6HT and pNESG_Avi6HT vectors (Table 1); many have E values E=5 (the maximum level typically observed) in the expression vectors using TOEET.

Construct designs for a larger set of more than 2,000 human transcription factor proteins and domains are listed in Table 2. A large number of the proteins listed in Table 2 have been cloned into vectors optimized by TOEET, such as the pNESG_Nano6HT and pNESG_Avi6HT vectors, and exhibit high levels expression and solubility. Analysis of these data indicates that both the pNESG_Nano6HT vector and pNESG_Avi6HT vectors produced greater expression and solubility levels than a standard pET15_NESG vector that has not been optimized using the TOETT technology described in this disclosure.

Overall, TOEET allows for the production of a significantly greater number of human proteins and protein domains. The higher ES values obtained using TOETT also allow for simpler production and purification of the target proteins, since high ES scores mean that the cell extract has a larger amount of the target protein relative to background proteins.

The pNESG_Avi6HT also allows for the production of protein samples that can be readily biotinylated in the EET tag sequence. The pNESG_Nano6HT tag also provides a means for simple production of a streptavidin-binding protein (Scholle et al., 2004). Such biotinylated or Nano-tagged protein samples can be used for a variety of processes, including phage display antibody production, as well as for screening and discovering protein-protein and protein—nucleic acid interactions.

Example 3

In certain applications, proteins that are expressed but not soluble in cell extracts can be solubilized and used successfully as antigens using various methods of solubilization, including urea and guanidine denaturants (Agaton et al. 2003). Accordingly, the ability to express a protein target, even it is not soluble in the high throughput Expression-Solubility screen described above [NESG High ThroughPut (HTP) Molecular Cloning and Expression Screening Platform methods] is critical, since if the protein cannot be expressed at all it is not possible to generate a suitable antigen. Accordingly, a particularly important value of the TOEET technology is enhancement of protein expression (E), regardless of the resulting solubility. To illustrate this point, histogram plots are presented in FIGS. 7a and 7b comparing Expression scores (E ranging from 0 to 5) using the TOEET technology (E_TOEET) compared to expression scores for the same target protein using a pET vector lacking TOEET technology (E_pET). The data shown in FIG. 7a is for 98 protein target genes cloned into the pNESG_Avi6HT TOEET vector compared with the exact same genes cloned into the pET15_NESG vector (lacking TOEET). The data shown in FIG. 7b is for 94 protein target genes cloned pNESG_Nano6HT TOEET vectors compared with the exact same genes cloned into pET15_NESG vector (lacking TOEET). In these histogram plots, a value E_TOEET−E_pET=0 indicates that the expression levels for both vectors were identical; values E_TOEET−E_pET>0 indicate that the TOEET technology provided higher level expression, values E_TOEET−E_pET<0 indicate that the TOEET technology provided lower level expression. For both target sets, the vast majority of genes exhibit much higher expression in the pNESG_Avi6HT TOEET and pNESG_Nano6HT TOEET vectors compared with the pET15_NESG vector (lacking TOEET). In many cases, E_TOEET−E_pET is 4 or 5, indicating that the expression in the non-TOEET vector was 0 or 1, which is too low to be useful for antigen production. Thus the TOEET vectors often provide high level expression of proteins which cannot be expressed at all, or those with are otherwise expressed as such marginal levels as to be useless for antigen production.

Example 4

A representative method for practicing certain embodiments of the invention is described below.

The first step in the method is to identify the residues of the chosen tag/protein and the corresponding DNA sequences to be modified, for example, the 1^st30 residues of the tag/protein. Low usage codons are identified and are changed to optimal codons either manually or using servers, for example, such as http://www.jcat.de/ or http://genomes.urv.es/OPTIMIZER/, among others (Step 2). The transcription start site of vector and the resulting 5′ untranslated region is then identified (Step 3). The 5′ UTR RNA sequence is fused in silico with the optimized RNA sequence encoding the tag/protein (e.g., the first 30 residues of the tag/protein) (Step 4). Various RNA secondary structure prediction methods may then be used to analyze the fused sequence, such as, for example: http://www.genebee.msu.su/services/rna2_reduced.html, http://rna.tbi.univie.ac.at/cgi-bin/RNAfold.cgi (Maximum Free Energy with partition function) or http://www.ncrna.org/centroidfold/ (Centroid Estimators-Statistical Decision Theory) (Step 5). The RBS and Initiation codon (IC) are then identified in the secondary structure prediction and the RNA positions in the first, e.g., 30 residues of the tag/protein that pair to the RBS/IC regions are determined (Step 6). Subsequently, alternative high frequency codons for the given residues base pairing with the RBS/IC are substituted and secondary structure is recalculated (Step 7). Steps 5 through 7 may be repeated until the secondary structure in RBS/IC is minimized and there is general agreement with the between the prediction servers (e.g., multiple predication servers may be used, such as the three servers listed above). This information is then used to design and produce the TOEET-optimized expression vector. Target proteins may then be cloned and expressed into the resulting expression system using the NESG Construct Optimization Software and High ThroughPut (HTP) Molecular Cloning and Expression Screening Platform and Automated Purification Pipeline methods, as outlined above.

TABLE 1

Expression Results

embedded image

E = Expression; E = 0-5 (no to high expression)

S = Solubility; S = 0-5 (no to high solubility)

ES = E * S = (0-25) ES ≧ 9 usability (highlighted with grey fill)

ES ≧ 9 (typically results in ≧5 milligrams of protein per one liter of E. coli Fermentation)

TABLE 2

Human transcription factor protein and domain constructs designed using the NESG Construct

Optimization Software for production using TOEET technologies. Each line in the table

describes a unique protein construct for RT-PCR cloning, defined by the NESG Vector ID,

the HUGO protein identifier, the Uniprot protein identifier, the first 15 amino acid

residues in the targeted construct, the last 15 amino acid residues in the target

construct, and the length of the targeted gene. The actual length of the targeted

gene obtained by RT-PCR may be shorter or longer than indicated in the table

due RNA spicing variations.

Construct

Vector
HUGO
Uniprot
First 15aa
Last 15aa
Length

HR7152A-140-202-TEV
ADAR
P55265
PVHYNGPSKAGYVDF
YSHGLPRCSPYKKLT
63

HR7675A-754-849-NHT
ADNP
Q9H2P0
LDPKGHEDDSYEARK
KHEMDFDAEWLFENH
96

HR7633A-1032-1131-NHT
ADNP2
Q6IQ32
KDEALQILALDPKKY
ELKNVKHRLNFEYEP
100

HR4425-1-595-15
AHR
P35869
MNSSSANITYASRKR
ILTYVQDSLSKSPFI
595

HR4425B-277-391-14
AHR
P35869
MILEIRTKNFIFRTK
DYIIVTQRPLTDEEG
116

HR4425B-277-406-14
AHR
P35869
MILEIRTKNFIFRTK
TEHLRKRNTKLPFMF
131

HR4425B-282-386-14
AHR
P35869
MTKNFIFRTKHKLDF
KNGRPDYIIVTQRPL
106

HR4425B-282-403-14
AHR
P35869
MTKNFIFRTKHKLDF
EEGTEHLRKRNTKLP
123

HR4425C-102-179-15
AHR
P35869
MRAANFREGLNLQEG
EDRAEFQRQLHWALN
79

HR4425C-108-178-14
AHR
P35869
MEGLNLQEGEFLLQA
TEDRAEFQRQLHWAL
72

HR4425C-97-184-15
AHR
P35869
MGQDNCRAANFREGL
FQRQLHWALNPSQCT
89

HR4425D-318-386-14
AHR
P35869
MRGSGYQFIHAADML
KNGRPDYIIVTQRPL
70

HR6398A-1-104-15
AIRE
O43918
MATDAALRRLLRLHR
YGRLQPILDSFPKDV
104

HR6398A-1-91-15
AIRE
O43918
MATDAALRRLLRLHR
FWRVLFKDYNLERYG
91

HR6398A-1-96-15
AIRE
O43918
MATDAALRRLLRLHR
FKDYNLERYGRLQPI
96

HR4766B-14-107-14
AKAP8
O43823
MGPANTQGAYGTGVA
IAKINQRLDMMSKEG
95

HR4766B-19-107-14
AKAP8
O43823
MQGAYGTGVASWQGY
IAKINQRLDMMSKEG
90

HR8040A-384-551-Av6HT
AKAP8L
Q9ULX6
VERIQFVCSLCKYRT
KKLERYLKGENPFTD
168

HR6457-14
ALX1
Q15699
MEFLSEKFALKSPPS
RMKAKEHTANISWAM
326

HR7916A-159-235-Av6HT
ALX3
O95076
TFSTFQLEELEKVFQ
RNPFTAAYDISVLPR
77

HR4490C-209-280-NHT
ALX4
Q9H161
SNKGKKRRNRTTFTS
RAKWRKRERFGQMQQ
72

HR6941A-510-703-NHT
ANAPC2
Q9UJX6
GSKDLFINEYRSLLA
VALLRRRMSVWLQQG
194

HR6941A-511-695-Av6HT
ANAPC2
Q9UJX6
SKDLEINEYRSLLAD
LSKAVKMPVALLRRR
185

HR6941B-732-822-Av6HT
ANAPC2
Q9UJX6
SDDESDSGMASQADQ
LVYSAGVYRLPKNCS
91

HR6941B-765-822-Av6HT
ANAPC2
Q9UJX6
LESLSLDRIYNMLRM
LVYSAGVYRLPKNCS
58

HR6941C-498-713-Av6HT
ANAPC2
Q9UJX6
SSDIISLLVSIYGSK
WLQQGVLREEPPGTF
216

HR6941C-510-713-Av6HT
ANAPC2
Q9UJX6
GSKDLFINEYRSLLA
WLQQGVLREEPPGTF
204

HR8423A-486-593-Av6HT
ANKZF1
Q9H8Y5
AKAPGQPELWNALLA
STRNEFRRFMEKNPD
108

HR5083-14
APEX2
Q9UBZ4
MLRVVSWNINGIRRP
DPSSRCNFFLWSRPS
518

HR5083A-1-319-14
APEX2
Q9UBZ4
MLRVVSWNINGIRRP
CPVGAVLSVSSVPAK
319

HR5083A-1-323-14
APEX2
Q9UBZ4
MLRVVSWNINGIRRP
AVLSVSSVPAKQCPP
323

HR5083A-1-352-14
APEX2
Q9UBZ4
MLRVVSWNINGIRRP
KILRFLVPLEQSPVL
352

HR5083A-1-357-14
APEX2
Q9UBZ4
MLRVVSWNINGIRRP
LVPIEQSPVLEQSTL
357

HR8294A-15-116-TEV
APTX
Q7Z2E3
RVCWLVRQDSRHQRI
HMVNELYPYIVEFEE
100

HR7650B-267-331-TEV
ARHGAP35
Q9NRY4
SQQIATAKDKYEWLV
AKKLFLQHIHRLKHE
65

HR7542A-507-616-NHT
ARID2
Q68CP9
QHVAPPPGIVEIDSE
RAIPLPIQMYYQQQP
110

HR4394C-14
ARID3A
Q99856
MPDHGDWTYEEQFKQ
ELQAAIDSNRREGRR
135

HR4394C-15
ARID3A
Q99856
MPDHGDWTYEEQFKQ
ELQAAIDSNRREGRR
135

HR4394C-218-351-Av6HT
ARID3A
Q99856
MPDHGDWTYEEQFKQ
ELQAAIDSNRREGRR
135

HR4394C-218-351-TEV
ARID3A
Q99856
PDHGDWTYEEQFKQL
ELQAAIDSNRREGRR
134

HR8410A-318-424-TEV
ARID5B
Q14865
RADEQAFLVALYKYM
KGEEDKPLPPIKPRK
107

HR7845A-354-470-TEV
ARNT
P27540
SNVCQPTEFISRHNI
YIICTNTNVKNSSQE
116

HR7821A-334-439-TEV
ARNT2
Q9HBZ2
PTEFLSRHNSDGIIT
SDEIEYIICTNTNVK
106

HR7274A-178-295-NHT
ARNTL2
Q8WYA1
QDNELRHLILKTAEG
SFFCRIKSCKISVKE
118

HR6915A-334-389-TEV
ARX
Q96Q53
TFTSYQLEELERAFQ
WFQNRRAKWRKREKA
56

HR4461B-112-194-14
ASCL1
P50553
MLPQQQPAAVARRNE
VSAAFQAGVLSPTIS
84

HR4461B-112-210-14
ASCL1
P50553
MLPQQQPAAVARRNE
NYSNDLNSMAGSPVS
100

HR4461B-132-189-14
ASCL1
P50553
MKLVNLGFATLREHV
DEHDAVSAAFQAGVL
59

HR4461B-132-206-14
ASCL1
P50553
MKLVNLGFATLREHV
TISPNYSNDLNSMAG
76

HR4461B-146-206-14
ASCL1
P50553
MPNGAANKKMSKVET
TISPNYSNDLNSMAG
62

HR4510B-64-138-14
ASCL2
Q99929
MKLVNLGFQALRQHV
AVRPSAPRGPPGTTP
76

HR7137A-2665-2824-TEV
ASH1L
Q9NR48
YLMRDSRRTPDGHPV
PKKLTPKKDFSPHYV
160

HR3149-106-270-14
ATF1
P18846
SGQYIAIAPNGALQL
IEELKTLKDLYSNKS
165

HR3149-14
ATF1
P18846
MEDSHKSTTSETAPQ
EELKTLKDLYSNKSV
271

HR3149-15
ATF1
P18846
MEDSHKSTTSETAPQ
EELKTLKDLYSNKSV
271

HR3149-21
ATF1
P18846
MEDSHKSTTSETAPQ
EELKTLKDLYSNKSV
271

HR3149-87-270-14
ATF1
P18846
GVSAAVTSMSVPTPI
IEELKTLKDLYSNKS
184

HR3149-96-270-14
ATF1
P18846
SVPTPIYQTSSGQYI
IEELKTLKDLYSNKS
175

HR4498B-354-414-TEV
ATF2
P15386
KRRKFLERNRAAASR
LLRNEVAQLKQLLLA
61

HR4572-21-181-14
ATF3
P18847
MPCLSPPGSLVFEDF
RNLFIQQIKEGTLQS
162

HR4572B-103-170-14
ATF3
P18847
MCRNKKKEKTECLQK
RAQNGRTPEDERNLF
69

HR4572B-103-181-14
ATF3
P18847
MCRNKKKEKTECLQK
RNLFIQQIKEGTLQS
80

HR4572B-77-181-14
ATF3
P18847
MTKAEVAPEEDERKK
RNLFIQQIKEGTLQS
106

HR6914A-280-341-Av6HT
ATF4
P18848
MKKLKKMEQNKTAAT
LAKEIQYLKDLIEEV
63

HR6914A-280-341-TEV
ATF4
P18848
KKLKKMEQNKTAATR
LAKEIQYLKDLIEEV
62

HR4531-39-469-14
ATF7
P17544
MPARTDSVIIADQTP
SAAEAVATSVLTQMA
432

HR8374A-151-218-Av6HT
ATOH1
Q92858
KQVNGVQKQRRLAAN
AQIYINALSELLQTP
68

HR7270A-225-288-NHT
ATOH8
Q96SQ7
KALQQTRRLLANARE
IACNYILSLARLADL
64

HR7350A-7-128-TEV
BACH1
O14867
SVFAYESSVHSTNVI
SVHNIEESCFQFLKF
122

HR8413A-12-132-Av6HT
BACH2
Q9BYV9
YVYESTVHCTNILLG
MHNLEDSCFSFLQTQ
121

HR7112A-169-265-NHT
BARHL1
Q9BZE3
DSPPVRLKKPRKART
SALQRMFPSPYFYPQ
97

HR7390A-223-314-NHT
BARHL2
Q9NY43
ESPPVRAKKPRKART
EAGNYSALQRMFPSP
92

HR7183A-133-199-TEV
BARX1
Q9HBU1
GEPGTKAKKGRRSRT
QVKTWYQNRRMKWKK
67

HR7561-1-174-Av6HT
BARX2
Q9UMQ3
HCHAELRLSSPGQLK
TPDRLDLAQSLGLTQ
173

HR7561-1-187-Av6HT
BARX2
Q9UMQ3
HCHAELRLSSPGQLK
TQLQVKTWYQNRRMK
186

HR7561-1-196-Av6HT
BARX2
Q9UMQ3
HCHAELRLSSPGQLK
QNRRMKWKKMVLKGG
195

HR7561A-118-196-Av6HT
BARX2
Q9UMQ3
SSESETEQPTPRQKK
QNRRMKWKKMVLKGG
79

HR6459-34-125-14
BATF
Q16520
EKNRIAAQKSRQRQT
HAFHQPHVSSPRFQP
92

HR6459-34-125-15
BATF
Q16520
EKNRIAAQKSRQRQT
HAFHQPHVSSPRFQP
92

HR6459A-19-125-14
BATF
Q16520
GKQDSSDDVRRVQRR
HAFHQPHVSSPRFQP
107

HR6459A-34-118-14
BATF
Q16520
EKNRIAAQKSRQRQT
PEVVYSAHAFHQPHV
85

HR7115A-1107-1202-NHT
BAZ1A
Q9NRL2
RSYKTVLDRWRESLL
GDWFCPECRPKQRSR
96

HR7115B-420-468-Av6HT
BAZ1A
Q9NRL2
LPPEIFGDALMVLEF
LEVLEEALVGNDSEG
49

HR7115B-420-486-Av6HT
BAZ1A
Q9NRL2
LPPEIFGDALMVLEF
ELLFFFLTAIFQAIA
67

HR7115C-1408-1534-Av6HT
BAZ1A
Q9NRL2
CRKRQSPEPSPVTLG
TRLQAFFHIQAQKLG
127

HR7115D-1420-1534-Av6HT
BAZ1A
Q9NRL2
TLGRRSSGRQGGVHE
TRLQAFFHIQAQKLG
115

HR7115D-1432-1534-Av6HT
BAZ1A
Q9NRL2
VHELSAFEQLVVELV
TRLQAFFHIQAQKLG
103

HR7115E-1-122-Av6HT
BAZ1A
Q9NRL2
PLLHRKPFVRQKPPA
IFAYVKDRYFVEETV
121

HR7115E-1-129-Av6HT
BAZ1A
Q9NRL2
PLLHRKPFVRQKPPA
RYFVEETVEVIRNNG
128

HR7115E-1-142-Av6HT
BAZ1A
Q9NRL2
PLLHRKPFVRQKPPA
NGARLQCRILEVLPP
141

HR7115E-22-122-Av6HT
BAZ1A
Q9NRL2
EEVFYCKVTNEIFRH
IFAYVKDRYFVEETV
101

HR7115E-22-129-Av6HT
BAZ1A
Q9NRL2
EEVFYCKVTNEIFRH
RYFVEETVEVIRNNG
108

HR7115E-22-142-Av6HT
BAZ1A
Q9NRL2
EEVFYCKVTNEIFRH
NGARLQCRILEVLPP
121

HR7190A-1634-1742-NHT
BAZ2A
Q9UIF9
SYEITPRIRVWRQTL
VEGEFTQKPGFPKRG
109

HR8090A-2062-2166-TEV
BAZ2B
Q9UIF8
DSKDLALCSMILTEM
NMRKYFEKKWTDTFK
105

HR7285A-80-154-TEV
BBX
Q8WY36
ARRPMNAFLLFCKRH
FMKANPGYKWCPTTN
75

HR4436B-523-602-14
BCL6
P41182
MCDCRFSEEASLKRH
NLKTHTRIHSGEKPY
81

HR4436B-523-606-14
BCL6
P41182
MCDCRFSEEASLKRH
HTRIHSGEKPYKCET
85

HR4436B-528-601-14
BCL6
P41182
MSEEASLKRHTLQTH
ANLKTHTRIHSGEKP
75

HR4436B-540-602-14
BCL6
P41182
MTHSDKPYKCDRCQA
NLKTHTRIHSGEKPY
64

HR4436B-542-598-14
BCL6
P41182
MSDKPYKCDRCQASF
NRPANLKTHTRIHSG
58

HR4436C-5-129-TEV
BCL6
P41182
ADSCIQFTRHASDVL
EHVVDTCRKFIKASE
125

HR7156A-284-387-Av6HT
BDP1
A6H8Y1
ERGSTTTYSSFRKNY
KVLAEEEKRKQKSVK
104

HR8401A-71-161-Av6HT
BHLHA15
Q7RTS1
DSSIQRRLESNERER
PKLYQHYQQQQQVAG
91

HR7639A-64-125-Av6HT
BHLHA9
Q7RTU4
KARRMAANVRERKRI
IHRIAALSLVLRASP
62

HR8288A-236-314-Av6HT
BHLHE22
Q8NFJ8
KSKEQKALRLNINAR
LEEMRRLVAYLNQGQ
79

HR7576A-47-183-NHT
BHLHE4
O14503
EDSKETYKLPHRLIE
SQLVTHLHRVVSELL
137

HR7576B-142-174-Av6HT
BHLHE40
O14503
FCSGFQTCAREVLQY
HENTRDLKSSQLVTH
33

HR7576B-142-181-Av6HT
BHLHE40
O14503
FCSGFQTCAREVLQY
KSSQLVTHLHRVVSE
40

HR7518A-44-116-NHT
BHLHE41
Q9C0J9
TYKLPHRLIEKKRRD
LTEQQHQKIIALQNG
73

HR3082 1-125 pET15TEV_NESG (in
BLOC1S1
P78537
MLSRLLKEHQAKQNE
ALEYVYKGQLQSAPS
125

progress)

HR3082-1-119-14
BLOC1S1
P78537
MLSRLLKEHQAKQNE
MRTIATALEYVYKGQ
119

HR3082-14
BLOC1S1
P78537
MLSRLLKEHQAKQNE
ALEYVYKGQLQSAPS
125

HR3082-MBP3
BLOC1S1
P78537
MLSRLLKEHQAKQNE
LEYVYKGQLQSAPS*
126

HR3082A-32-125-14
BLOC1S1
P78537
TCLTEALVDHLNVGV
ALEYVYKGQLQSAPS
94

HR3082B-43-125-15
BLOC1S1
P78537
MNVGVAQAYMNQRKL
ALEYVYKGQLQSAPS
84

HR7816A-294-396-NHT
BMP2
P12643
SSCKRHPLYVDFSDV
LKNYQDMVVEGCGCR
103

HR7816A-294-396-TEV
BMP2
P12643
SSCKRHPLYVDFSDV
LKNYQDMVVEGCGCR
103

HR7409A-9-128-TEV
BOLA1
Q9Y3E2
GLVSMAGRVCLCQGS
WRENSQIDTSPPCLG
120

HR8185-1-86-TEV
BOLA2B
Q9H3K6
ASAKSLDRWKARLLE
EYLREKLQRDLEAEH
85

HR7562-8-107-Av6HT
BOLA3
Q53533
AAAPLLRGIRGLPLH
KEMHGLRIFTSVPKR
100

HR7886A-6-308-TEV
BPNT1
O95861
TVLMRLVASAYSIAQ
YASRVPESIKNALVP
303

HR7955A-134-243-TEV
BRD9
Q9H8M2
KDKIVANEYKSVTEF
EPEGNACSLTDSTAE
110

HR6995B-633-746-TEV
BRPF1
P55201
FLILLRKTLEQLQEK
GAVLRQARRQAEKMG
114

HR8142A-104-176-Av6HT
BSX
Q3C1V8
PGKHGRRRKARTVFS
RMKHKKQLRKSQDEP
73

HR1875-14
C12orf28
Q96LU7
MAFCALTIVALYILS
IFFTDYFFYFYRRCA
275

HR7476A-824-884-NHT
C14orf43
Q6PIG2
TYHYTGSDQWKMAER
FYYTYKKQVKIGRNG
61

HR7019A-867-954-TEV
CAMTA1
Q9Y6Y1
SGRVFMVTDYSPEWS
NNQIISNSVVFEYKA
88

HR7019B-108-183-TEV
CAMTA1
Q9Y6Y1
ILYNRKKVKYRKDGY
LQNPDIVLVHYLNVP
76

HR7019B-69-183-TEV
CAMTA1
Q9Y6Y1
KERHRWNTNEEIAAY
LQNPDIVLVHYLNVP
115

HR7019B-73-183-TEV
CAMTA1
Q9Y6Y1
RWNTNEEIAAYLITF
LQNPDIVLVHYLNVP
111

HR7019C-1029-1162-Av6HT
CAMTA1
Q9Y6Y1
ALGSCFESRVVVVCE
LGIARSRGHVKLAEC
134

HR7019C-1029-1168-Av6HT
CAMTA1
Q9Y6Y1
ALGSCFESRVVVVCE
RGHVKLAECLEHLQR
140

HR7019C-1058-1162-Av6HT
CAMTA1
Q9Y6Y1
IHSKTFRGMTLLHLA
LGIARSRGHVKLAEC
105

HR7019C-1058-1168-Av6HT
CAMTA1
Q9Y6Y1
IHSKTFRGMTLLHLA
RGHVKLAECLEHLQR
111

HR7019D-1486-1624-Av6HT
CAMTA1
Q9Y6Y1
KPNLPSAADWSEFLS
CGKRRQARRTAVIVQ
139

HR7019D-1486-1660-Av6HT
CAMTA1
Q9Y6Y1
KPNLPSAADWSEFLS
FLRRCRHSPLVDHRL
175

HR7019D-1501-1673-Av6HT
CAMTA1
Q9Y6Y1
ASTSEKVENEFAQLT
RLYKRSERIEKGQGT
173

HR7019D-1513-1624-Av6HT
CAMTA1
Q9Y6Y1
QLTLSDHEQRELYEA
CGKRRQARRTAVIVQ
112

HR7019D-1513-1660-Av6HT
CAMTA1
Q9Y6Y1
QLTLSDHEQRELYEA
FLRRCRHSPLVDHRL
148

HR7295A-60-130-Av6HT
CARHSP1
Q9Y2V2
GPVYKGVCKCFCRSK
PKNEKLQAVEVVITH
71

HR8150A-1916-1982-Av6HT
CASP8AP2
Q9UKL3
KNVIKKKGEIIILWT
RFQQLMKLFEKSKCR
67

HR7269A-2-135-Av6HT
CBFB
Q13951
MPRVVPDQRSKFENE
GMGCLEFDEERAQQE
135

HR7269A-2-135-TEV
CBFB
Q13951
PRVVPDQRSKFENEE
GMGCLEFDEERAQQE
134

HR7615A-104-190-NHT
CBLL1
Q75N03
TPVHFCDKCGLPIKI
YLSQRDLQAHINHRH
87

HR6520A-9-62-Av6HT
CBX2
Q14781
MEQVFAAECILSKRL
NILDPRLLLAFQKKE
55

HR6520A-9-62-TEV
CBX2
Q14781
EQVFAAECILSKRLR
NILDPRLLLAFQKKE
54

HR8494A-624-717-Av6HT
CCDC79
Q8NA31
IVEAEDRYKSELRKS
QQGRKAVDLAHKYHK
94

HR8086A-57-112-TEV
CDC5L
Q99459
SIKKIEWSREEEEKL
EHYEFLLDKAAQRDN
56

HR7252A-160-214-Av6HT
CDX1
P47902
VYTDHQRLELEKEFH
IWFQNRRAKERKVNK
55

HR7064A-185-251-Av6HT
CDX2
Q99626
TKDKYRVVYTDHQRL
RRAKERKINKKKLQQ
67

HR7957A-172-246-Av6HT
CDX4
O14627
TKEKYRVVYTDHQRL
IKKKISQFENSGGSV
75

HR7823A-281-340-TEV
CEBPA
P49715
NSNEYRVRRERNNIA
KRVEQLSRELDTLRG
60

HR4764B-273-336-TEV
CEBPB
P17676
EYKIRRERNNIAVRK
RELSTLRNLFKQLPE
64

HR7557A-190-272-15
CEBPE
Q15744
MAGPLHKGKKAVNKD
DTLRNLFRQIPEAAN
84

HR7557A-195-268-15
CEBPE
Q15744
MKGKKAVNKDSLEYR
TQELDTLRNLFRQIP
75

HR7557A-195-281-15
CEBPE
Q15744
MKGKKAVNKDSLEYR
IPEAANLIKGVGGCS
88

HR7557A-203-281-15
CEBPE
Q15744
MDSLEYRLRRERNNI
IPEAANLIKGVGGCS
80

HR6439-59-150-Av6HT
CEBPG
P53567
DRNSDEYRQRRERNN
ISTENTTADGDNAGQ
92

HR8022A-431-525-Av6HT
CENPT
Q96BT3
EPAEPLLVRHPPRPR
KPEDLELLMRRQGLV
95

HR7210A-268-373-Av6HT
CHD1
O14646
MEEEFETIERFMDCR
TKRWLKNASPEDVEY
107

HR7210A-268-373-TEV
CHD1
O14646
EEEFETIERFMDCRI
TKRWLKNASPEDVEY
106

HR7330A-260-394-NHT
CHD2
O14647
SETIEKVLDSRLGKK
VERVIAVKTSKSTLG
135

HR7397A-371-431-TEV
CHD6
Q8TD26
NPDYVEVDRILEVAH
DVDPAKVKEFESLQV
61

HR7397B-679-941-Av6HT
CHD6
Q8TD26
LRRLKDDVEKNLAPK
LDKAVLQDINRKGGT
262

HR7397B-679-968-Av6HT
CHD6
Q8TD26
LRRLKDDVEKNLAPK
DLLRKGAYGALMDEE
289

HR7397B-679-974-Av6HT
CHD6
Q8TD26
LRRLKDDVEKNLAPK
AYGALMDEEDEGSKF
295

HR7397B-679-997-Av6HT
CHD6
Q8TD26
LRRLKDDVEKNLAPK
LQRRTHTITIQSEGK
318

HR8217A-2631-2715-TEV
CHD7
Q9P2D1
RNPNKLDINTLTGEE
DRLLTGPVVRGEGAS
85

HR8217B-2561-2614-TEV
CHD7
Q9P2D1
GQLDPDTRIPVINLE
TYTVDMPSYVPKNAD
54

HR7629A-1-98-NHT
CHRAC1
Q9NRG0
ADVVVGKDKGGEQRL
SETFQFLADILPKKI
97

HR7688A-98-186-NHT
CLOCK
O15516
QDWKPTFLSNEEFTQ
THLLESDSLTPEYLK
89

HR7654A-1987-2362-TEV
CNOT1
A5YKK6
QLPYHRIFIMLLLEL
EIEKLFQSVAQCCMG
376

HR7654B-1987-2369-TEV
CNOT1
A5YKK6
QLPYHRIFIMLLLEL
SVAQCCMGQKQAQQV
383

HR7654B-1987-2376-TEV
CNOT1
A5YKK6
QLPYHRIFIMLLLEL
GQKQAQQVMEGTGAS
390

HR2981-28-443-15
COPS2
P61201
MPNVDLENQYYNSKA
NQLNSLNQAVVSKLA
417

HR2981-301-418-14
COPS2
P61201
PYKNDPEILAMTNLV
QVNQLLELDHQKRGG
118

HR2981-45-443-15
COPS2
P61201
MDDPKAALSSFQKVL
NQLNSLNQAVVSKLA
400

HR2981A-306-415-14
COPS2
P61201
PEILAMTNLVSAYQN
RIDQVNQLLELDHQK
110

HR2981B-339-418-14
COPS2
P61201
DDPFIREHIEELLRN
QVNQLLELDHQKRGG
80

HR2981C-45-163-15
COPS2
P61201
MDDPKAALSSFQKVL
FKTNTKLGKLYLERE
120

HR2981C-45-184-15
COPS2
P61201
MDDPKAALSSFQKVL
KILRQLHQSCQTDDG
141

HR2981C-45-210-15
COPS2
P61201
MDDPKAALSSFQKVL
EIYALEIQMYTAQKN
167

HR3016-1-411-14
COPS3
Q9UNS2
MASALEQFVNSVRQL
ITVNPQFVQKSMGSQ
411

HR3016-14
COPS3
Q9UNS2
MASALEQFVNSVRQL
GSQEDDSGNKPSSYS
423

HR3016A-49-114-15
COPS3
Q9UNS2
LDVQEHSLGVLAVLF
FAGLCHQLTNALVER
66

HR3016B-88-154-15
COPS3
Q9UNS2
CNGEHIRYATDTFAG
SIHADLCQLCLLAKC
67

HR3016C-270-368-15
COPS3
Q9UNS2
NNPSELRNLVNKHSE
KDGMVSFHDNPEKYN
99

HR3016C-270-396-15
COPS3
Q9UNS2
NNPSELRNLVNKHSE
KCIELDERLKAMDQE
127

HR3016C-270-411-15
COPS3
Q9UNS2
NNPSELRNLVNKHSE
ITVNPQFVQKSMGSQ
142

HR3016D-352-413-15
COPS3
Q9UNS2
NQKDGMVSFHDNPEK
VNPQFVQKSMGSQED
62

HR3016D-358-409-15
COPS3
Q9UNS2
VSFHDNPEKYNNPAM
QEITVNPQFVQKSMG
52

HR3105-1-292-15
COPS4
Q9BT78
MAAAVRQDLAQLMNS
LQEFAAMLMPHQKAT
292

HR3105-1-297-15
COPS4
Q9BT78
MAAAVRQDLAQLMNS
AMLMPHQKATTADGS
297

HR3105-15
COPS4
Q9BT78
MAAAVRQDLAQLMNS
APEWTAQAMEAQMAQ
406

HR6309A-15
CPSF4
O95639
MSGEKTVVCKHWLRG
NKECPFLHIDPESKI
62

HR7458A-62-130-NHT
CPSF4L
A6NMK7
GEKMVVCKHWLRGLC
KPAFKSQDCPWYDQG
69

HR3140-21
CREB1
P16220
MTMESGAENQQSGDA
EELKALKDLYCHKSD
341

HR6927-139-461-Av6HT
CREB3L3
Q68CJ9
PVIQVPEASVTIDLE
TGSGRAGLEAAGDEL
323

HR7960-1-298-Av6HT
CREB3L4
Q8TEY5
DLGIPDLLDAWLEPP
IAQTSNKAAQTSTCV
297

HR6873A-34-89-Av6HT
CRX
O43186
SAPRKQRRERTTFTR
KINLPESRVQVWFKN
56

HR6873A-45-103-Av6HT
CRX
O43186
TFTRSQLEELEALFA
NRRAKCRQQRQQQKQ
59

HR8272A-84-160-NHT
CSDA
P16989
KKVLATKVLGTVKWF
VEGEKGAEAANVTGP
77

HR7792B-673-744-TEV
CSDE1
O75534
LRRATVECVKDQFGF
CSACNVWRVCEGPKA
72

HR7173A-399-462-TEV
CTCF
P49711
RTHSGEKPYECYICH
RKSDLGVHLRKQHSY
64

HR7173B-515-592-Av6HT
CTCF
P49711
MRTHTGEKPYACSHC
AGPDGVEGENGGETK
79

HR7173B-515-592-TEV
CTCF
P49711
RTHTGEKPYACSHCD
AGPDGVEGENGGETK
78

HR7558A-411-776-TEV
CUL1
Q13616
AQSSSKSPELLARYC
LERVDGEKDTYSYLA
365

HR7558B-15-410-Av6HT
CUL1
Q13616
IGLDQIWDDLRAGIQ
DKACGRFINNNAVTK
396

HR3327B-643-745-14
CUL2
Q13617
NFSSKRTKFKITTSM
IERSQASADEYSYVA
103

HR3327B-655-745-14
CUL2
Q13617
TSMQKDTPQEMEQTR
IERSQASADEYSYVA
91

HR3327C-1-408-15
CUL2
Q13617
MSLKPRVVDFDETWN
YCDNLLKKSAKGMTE
408

HR3327D-4-745-TEV
CUL2
Q13617
KPRVVDFDETWNKLL
IERSQASADEYSYVA
742

HR3437D-677-768-TEV
CUL3
Q13618
VAAKQGESDPERKET
LARTPEDRKVYTYVA
92

HR3342C-672-759-TEV
CUL4A
Q13619
IQMKETVEEQVSTTE
MERDKDNPNQYHYVA
88

HR7263A-808-895-TEV
CUL4B
Q13620
IQMKETVEEQASTTE
MERDKENPNQYNYIA
88

HR3340C-7-395-Av6HT
CUL5
Q93034
LKNKGSLQFEDKWDF
TIFKLELPLKQKGVG
389

HR8510A-825-917-TEV
CUX2
O14529
PRGDEAPVPPEDEAA
RQVKEKLAKNGICQR
93

HR7807A-15-94-Av6HT
CXXC1
Q9P0U4
EDSKSENGENAPIYC
LEIRYRHKKSRERDG
80

HR7690A-184-282-TEV
DACH1
Q9UI36
TPQNNECKMVDLRGA
LISRKDFETLYNDCT
99

HR6867A-61-162-TEV
DACH2
Q96NX9
GNTNTNECRMVDMHG
TRKDFETLFTDCTNA
102

HR7176A-249-325-Av6HT
DBP
Q10586
VPEEQKDEKYWSRRY
YRAVLSRYQAQHGAL
77

HR7176A-254-325-Av6HT
DBP
Q10586
KDEKYWSRRYKNNEA
YRAVLSRYQAQHGAL
72

HR7911A-178-244-Av6HT
DBX2
Q6ZNG2
DSNSKARRGILRRAV
VKIWFQNRRMKWRNS
67

HR7702A-201-279-NHT
DEAF1
O75398
SELPVRCRNISGTLY
CLIQDGILNPHAASG
79

HR7922A-11-108-TEV
DEPDC1A
Q5TB30
YRATKLWNEVTTSFR
SENVDDNNQLFRFPA
98

HR7073A-153-209-TEV
DLX2
Q07687
RKPRTIYSSFQLAAL
QVKIWFQNRRSKFKK
57

HR8208A-130-186-TEV
DLX3
O60479
RKPRTIYSSYQLAAL
QVKIWFQNRRSKFKK
57

HR7595A-138-194-TEV
DLX5
P56178
RKPRTIYSSFQLAAL
QVKIWFQNKRSKIKK
57

HR8524A-46-106-TEV
DLX6
P56179
GKKIRKPRTIYSSLQ
QVKIWFQNKRSKFKK
61

HR4696-44-404-15
DMAP1
Q9NPF5
MTLTFKRPEGMHREV
MLRHRHEALARAGVL
362

HR4696-49-403-15
DMAP1
Q9NPF5
MRPEGMHREVYALLY
QMLRHRHEALARAGV
356

HR4696B-208-404-15
DMAP1
Q9NPF5
MVPGTDLKIPVFDAG
MLRHRHEALARAGVL
198

HR4696B-213-404-15
DMAP1
Q9NPF5
MLKIPVFDAGHERRR
MLRHRHEALARAGVL
193

HR4696B-236-403-15
DMAP1
Q9NPF5
MRTPEQVAEEEYLLQ
QMLRHRHEALARAGV
169

HR7582A-79-146-Av6HT
DMBX1
Q8NFW5
TAQQLEALEKTFQKT
SLQKEQLQKQKEAEG
68

HR7142-1-340-TEV
DMC1
Q14565
KEDQVVAEEPGFQDE
ATFAITAGGIGDAKE
339

HR8371A-114-182-Av6HT
DMRT2
Q9Y5R5
PRKLSRTPKCARCRN
LRRQQATEDKKGLSG
69

HR7805A-20-88-NHT
DMRT3
Q9NQL9
RAPLQRTPKCARCRN
LRRQQANESLESLIP
69

HR6947A-318-361-NHT
DMRTA1
Q5VZB9
SLPTVSSRPRDPLDI
GILRFCKGDVVQAIE
44

HR7753A-1-53-NHT
DMRTB1
Q96MA1
ADKMVRTPKCSRCRN
KCYLISERQKIMAAQ
52

HR7387A-44-84-Av6HT
DMRTC2
Q8IXT2
RCRNHGVTAHLKGHK
KCVLILERRRVMAAQ
41

HR8011A-205-276-15
DMTF1
Q9Y222
MSTEPGDIVTQGVSW
RIAELDVADENDINW
78

HR8011A-205-293-15
DMTF1
Q9Y222
MSTEPGDIVTQGVSW
LAEGWSSVRSPQWLR
90

HR8011B-255-339-15
DMTF1
Q9Y22
MDEINLILRIAELDV
QKNNPTLLENKSGSG
86

HR8011B-255-356-15
DMTF1
Q9Y222
MDEINLILRIAELDV
NSNTNSSVQHVQIRV
103

HR8011B-268-339-15
DMTF1
Q9Y222
MVADENDINWDLLAE
QKNNPTLLENKSGSG
73

HR8011B-268-356-15
DMTF1
Q9Y222
MVADENDINWDLLAE
NSNTNSSVQHVQIRV
90

HR6887A-327-385-TEV
DNAIC1
Q96KC8
APEWTEEDLSQLTRS
AKQLKDSVTCSPGMV
59

HR7581A-1-76-NHT
DNAJC21
Q5F1R6
KCHYEALGVRRDASE
RAWYDNHREALLKGG
75

HR8109A-314-391-Av6HT
DPF2
Q92785
AAVKTYRWQCIECKC
LLKEKASIYQNQNSS
77

HR8202A-15-83-Av6HT
DPRX
A6NFQ7
HSHRKRTMFTKKQLE
AKLKKAKCKHIHQKQ
69

HR7601-1-176-Av6HT
DR1
Q01658
MASSSGNDDDLTIPR
NQAGSSQDEEDDDDI
176

HR7601-1-176-TEV
DR1
Q01658
ASSSGNDDDLTIPRA
NQAGSSQDEEDDDDI
175

HR6975A-1-77-TEV
DRAP1
Q14919
PSKKKKYNARFPPAR
KTMTTSHLKQCIELE
76

HR7517A-25-174-NHT
DUSP12
Q9UNI6
GQMLEVQPGLYFGGA
WQLKLYQAMGYEVDT
150

HR7523A-86-164-NHT
DUXA
A6NLW8
SQGQDQPGVEFQSRE
QNRRSRLLLQRKREP
79

HR4713B-251-345-TEV
DVL1
O14640
TVTLNMERHHFLGIS
ISLTVAKCWDPTPRS
95

HR5191A-15
DVL1L1
P54792
MTVTLNMERHHFLGI
ISLTVAKAWDPTPRS
96

HR4606C-408-551-14
DVL2
O14641
MLPDGCEGRGLSVHT
APLPGATPWPLLPTF
145

HR4606C-412-526-14
DVL2
O14641
MCEGRGLSVHTDMAS
CESYLVNLSLNDNDG
116

HR4606C-417-519-14
DVL2
O14641
MLSVHTDMASVTKAM
FGDLSGGCESYLVNL
104

HR4606C-417-551-14
DVL2
O14641
MLSVHTDMASVTKAM
APLPGATPWPLLPTF
136

HR4606D-260-358-TEV
DVL2
O14641
TMSLNIITVTLNMEK
PGPIVLTVAKCWDPS
99

HR5528A-14
DVL2
O14641
MTITSGSSLPDGCEG
SEQCYYVFGDLSGGC
113

HR5528A-15
DVL2
O14641
MTITSGSSLPDGCEG
SEQCYYVFGDLSGGC
113

HR7051A-248-338-TEV
DVL3
Q92997
ITVTLNMEKYNFLGI
HKPGPITLTVAKGWD
91

HR7051B-397-504-15
DVL3
Q92997
MDTERLDDFHLSIHS
CYYIFGDLCGNMANL
109

HR7051B-397-511-15
DVL3
Q92997
MDTERLDDFHLSIHS
LCGNMANLSLHDHDG
116

HR7051B-397-530-15
DVL3
Q92997
MDTERLDDFHLSIHS
SDQDTLAPLPHPGAA
135

HR7051B-403-504-15
DVL3
Q92997
MDFHLSIHSDMAAIV
CYYIFGDCGGNMANL
103

HR7051B-403-530-15
DVL3
Q92997
MDFHLSIHSDMAAIV
SDQDTLAPLPHPGAA
129

HR7051C-1-79-TEV
DVL3
Q92997
GETKIIYHLDGQETP
AKLPCFNGRVVSWLV
78

HR4672B-14
E2F1
Q01094
PGEKSRYETSLNLTT
QGPIDVFLCPEETVG
183

HR4672C-116-196-14
E2F1
Q01094
MGKGVKSPGEKSRYE
KKSKNHIQWLGSHTT
82

HR4672C-121-192-14
E2F1
Q01094
MSPGEKSRYETSLNL
QLIAKKSKNHIQWLG
73

HR4672C-122-196-14
E2F1
Q01094
MPGEKSRYETSLNLT
KKSKNHIQWLGSHTT
76

HR4672C-127-192-14
E2F1
Q01094
MRYETSLNLTTKRFL
QLIAKKSKNHIQWLG
67

HR4672C-147-192-14
E2F1
Q01094
MADGVVDLNWAAEVL
QLIAKKSKNHIQWLG
47

HR4672D-192-301-TEV
E2F1
Q01094
GSHTTVGVGGRLEGL
KSKQGPIDVFLCPEE
110

HR6383-65-437-14
E2F2
Q14209
ATPHGPEGQVVRCLP
SDLFDSYDLGDLLIN
373

HR6383-70-437-14
E2F2
Q14209
PEGQVVRCLPAGRLP
SDLFDSYDLGDLLIN
368

HR6383A-195-308-15
E2F2
Q14209
RGMFEDPTRPGKQQQ
TQGPIEVYLCPEEVQ
114

HR6383A-198-296-15
E2F2
Q14209
FEDPTRPGKQQQLGQ
RTEDNLQIYLKSTQG
99

HR6383B-114-200-15
E2F2
Q14209
MGLPSPKTPKSPGEK
AKNNIQWVGRGMFED
88

HR6383B-114-204-15
E2F2
Q14209
MGLPSPKTPKSPGEK
IQWVGRGMFEDPTRP
92

HR6383B-119-195-15
E2F2
Q14209
MKTPKSPGEKTRYDT
LIRKKAKNNIQWVGR
78

HR6383B-119-195-Av6HT
E2F2
Q14209
KTPKSPGEKTRYDTS
LIRKKAKNNIQWVGR
77

HR6383B-119-115-TEV
E2F2
Q14209
KTPKSPGEKTRYDTS
LIRKKAKNNIQWVGR
77

HR6383C-126-200-15
E2F2
Q14209
MEKTRYDTSLGLLTK
AKNNIQWVGRGMFED
76

HR6383C-131-195-15
E2F2
Q14209
MDTSLGLLTKKFIYL
LIRKKAKNNIQWVGR
66

HR6383C-131-202-15
E2F2
Q14209
MDTSLGLLTKKFIYL
NNIQWVGRGMFEDPT
73

HR4418C-14
E2F3
O00716
KTRYDTSLGLLTKKF
QGPIEVYLCPEETET
182

HR4418D-14
E2F3
O00716
NNVQWMGCSLSEDGG
LCPEETETHSPMKTN
128

HR4470C-84-203-14
E2F4
Q16254
MVGPGCNTREIADKL
PIEVLLVNKEAWSSP
121

HR4470C-89-200-14
E2F4
Q16254
MNTREIADKLIELKA
VSGPIEVLLVNKEAW
113

HR4470D-11-86-TEV
E2F4
Q16254
PPGTPSRHEKSLGLL
EKKSKNSIQWKGVGP
76

HR4678B-113-232-14
E2F5
Q15329
MQWKGVGAGCNTKEV
KSHSGPIHVLLINKE
121

HR4678B-119-232-14
E2F5
Q15329
MAGCNTKEVIDRLRY
KSHSGPIHVLLINKE
115

HR4622-1-237-15
E2F6
O75461
MSQQRPARKLPSLLL
HIRSTNGPIDVYLCE
237

HR4622-1-242-15
E2F6
O75461
MSQQRPARKLPSLLL
NGPIDVYLCEVEQGQ
242

HR4622-19-242-15
E2F6
O75461
MEETVRRRCRDPINV
NGPIDVYLCEVEQGQ
225

HR4622-19-281-15
E2F6
O75461
MEETVRRRCRDPINV
EENPQQSEELLEVSN
264

HR4622-24-237-15
E2F6
O75461
MRRCRDPINVEGLLP
HIRSTNGPIDVYLCE
215

HR4622-24-281-15
E2F6
O75461
MRRCRDPINVEGLLP
EENPQQSEELLEVSN
259

HR4622-24-281-Av6HT
E2F6
O75461
RRCRDPINVEGLLPS
EENPQQSEELLEVSN
258

HR4622-24-281-TEV
E2F6
O75461
RRCRDPINVEGLLPS
EENPQQSEELLEVSN
258

HR4622B-128-247-15
E2F6
O75461
GSDLSNFGAVPQQKK
VYLCEVEQGQTSNKR
120

HR46228-133-243-15
E2F6
O75461
NFGAVPQQKKLQEEL
GPIDVYLCEVEQGQT
111

HR4622C-127-242-15
E2F6
O75461
IGSDLSNFGAVPQQK
NGPIDVYLCEVEQGQ
116

HR4622C-132-237-15
E2F6
O75461
SNFGAVPQQKKLQEE
HIRSTNGPIDVYLCE
106

HR4622D-54-137-15
E2F6
O75461
RKALKVKRPRFDVSL
HIRWIGSDLSNFGAV
84

HR4622D-54-180-15
E2F6
O75461
RKALKVKRPSFDVSL
QQLFELTDDKENERL
127

HR4622D-54-242-15
E2F6
O75461
RKALKVKRPRFDVSL
NGPIDVYLCEVEQGQ
189

HR4622D-58-132-15
E2F6
O75461
KVKRPRFDVSLVYLT
KKSKNHIRWIGSDLS
75

HR4622D-58-175-15
E2F6
O75461
KVKRPRFDVSLVYLT
IKDCAQQLFELTDDK
118

HR4622D-58-237-15
E2F6
O75461
KVKRPRFDVSLVYLT
HIRSTNGPIDVYLCE
180

HR8499A-141-251-Av6HT
E2F7
Q96AV8
SRKQKSLGLLCQKFL
YLQQKELDLIDYKFG
111

HR7611A-112-223-NHT
E2F8
A0AVK6
SRKEKSLGLLCHKFL
IKKKEYEQEFDFIKS
112

HR8342-1-508-Av6HT
E4F1
Q66K89
EGAMAVRVTAAHTAE
GDCGKLYKTIAHVRG
507

HR8342-1-600-Av6HT
E4F1
Q66K89
EGAMAVRVTAAHTAE
EHGTLNRHLRTKGGC
599

HR8342A-522-586-15
E4F1
Q66K89
MPKCGKRYKTKNAQQ
EKPFKCYKCGRGFAE
66

HR8342A-523-600-15
E4F1
Q66K89
MKCGKRYKTKNAQQV
EHGTLNRHLRTKGGC
79

HR8342A-527-581-15
E4F1
Q66K89
MRYKTKNAQQVHFRT
RHHTGEKPFKCYKCG
56

HR8342A-527-600-15
E4F1
Q66K89
MRYKTKNAQQVHFRT
EHGTLNRHLRTKGGC
75

HR8342B-51-219-15
E4F1
Q66K89
MEEDEDDVHRCGRCQ
SILKAHMVTHSSRKD
170

HR8342B-51-231-15
E4F1
Q66K89
MEEDEDDVHRCGRCQ
RKDHECKLCGASFRT
182

HR8342B-51-249-15
E4F1
Q66K89
MEEDEDDVHRCGRCQ
LIRHHRRHTDERPYK
200

HR8342B-56-214-15
E4F1
Q66K89
MDVHRCGRCQAEFTA
TFKTGSILKAHMVTH
160

HR8342B-56-226-15
E4F1
Q66K89
MDVHRCGRCQAEFTA
VTHSSRKDHECKLCG
172

HR8342B-56-244-15
E4F1
Q66K89
MDVHRCGRCQAEFTA
RTKGSLIRHHRRHTD
190

HR3014A-10-250-TEV
EBF1
Q9UH73
RSGSSMKEEPLGSGM
NNSKHGRRARRLDPS
241

HR7745A-10-250-TEV
EBF3
Q9H4W6
RGGTTMKEEPLGSGM
NNSKHGRRARRLDPS
241

HR6883A-10-251-TEV
EBF4
Q9BQW3
NLKEEPLLPAGLGSV
HGRRARRLDPSEAAT
242

HR7307A-71-148-Av6HT
EDF1
O60869
MDRVTLEVGKVIQQG
GKDIGKPIEKGPRAK
79

HR7307A-71-148-TEV
EDF1
O60869
DRVTLEVGKVIQQGR
GKDIGKPIEKGPRAK
78

HR7944A-1347-1411-TEV
EEA1
Q15075
RKWAEDNEVQNCMAC
KPVRVCDACFNDLQG
65

HR4555D-366-418-Av6HT
EGR1
P18146
MKPFQCRICMRNFSR
KFARSDERKRHTKIH
54

HR4555D-366-418-TEV
EGR1
P18146
KPFQCRICMRNFSRS
KFARSDERKRHTKIH
53

HR8206A-368-420-TEV
EGR2
P11161
KPFQCRICMRNFSRS
KFARSDERKRHTKIH
53

HR8198A-273-328-TEV
EGR3
Q06889
RPHACPAEGCDRRFS
FSRSDHLTTHIRTHT
56

HR8048A-204-299-TEV
EHF
Q9NZC4
PRGTHLWEFIRDILL
VYKFGKNARGWRENE
96

HR7395A-770-879-NHT
EIF3C
Q99613
PEADKVRTMLVRKIQ
SLVENNERVFDHKQG
110

HR2095-14
EIF3K
Q9UBQ5
MAMFEQMRANVGKLL
KIDFDSVSSIMASSQ
218

HR564-14
EIF3K
Q9UBQ5
MAMFEQMRANVGKLL
KIDFDSVSSIMASSQ
218

HR6332A-198-348-15
ELF1
P32519
KKNKDGKGNTIYLWE
SPGVKGGATTVLKPG
151

HR6332A-198-353-15
ELF1
P32519
KKNKDGKGNTIYLWE
GGATTVLKPGNSKAA
156

HR6332A-203-348-15
ELF1
P32519
GKGNTIYLWEFLLAL
SPGVKGGATTVLKPG
146

HR6332B-152-304-15
ELF1
P32519
ETQQVQEKYADSPGA
KEMPKDLIYINDEDP
153

HR6332B-157-299-15
ELF1
P32519
QEKYADSPGASSPEQ
LVYQFKEMPKDLIYI
143

HR6332B-157-304-15
ELF1
P32519
QEKYADSPGASSPEQ
KEMPKDLIYINDEDP
148

HR6332B-198-304-15
ELF1
P32519
KKNKDGKGNTIYLWE
KEMPKDLIYINDEDP
107

HR6332C-203-353-15
ELF1
P32519
GKGNTIYLWEFLLAL
GGATTVLKPGNSKAA
151

HR7067A-150-308-15
ELF2
Q15723
MLWEFLLDLLQDKNT
GVARVVNITSPGHDA
160

HR7067A-157-303-15
ELF2
Q15723
MLLQDKNTCPRYIKW
SRAEKGVARVVNITS
148

HR7067A-200-308-15
ELF2
Q15723
MNYETMGRALRYYYQ
GVARVVNITSPGHDA
110

HR7867A-45-132-TEV
ELF3
P78545
SNPQMSLEGTEKASW
GDQLHAQLRDLTSSS
88

HR7867B-269-371-TEV
ELF3
P78545
APRGTHLWEFIRDIL
NSSGWKEEEVLQSRN
103

HR8186A-1-104-TEV
ELF4
Q99607
AITLQPSDLIFEFAS
HTMSTAEVLLNMESP
103

HR8186A-1-87-TEV
ELF4
Q99607
AITLQPSDLIFEFAS
QILEGSFLLTDDNEA
86

HR8186A-1-94-TEV
ELF4
Q99607
AITLQPSDLIFEFAS
LLTDDNEATSHTMST
93

HR7396A-166-265-TEV
ELF5
Q9UKW6
SRTSLQSSHLWEFVR
YKFGKNAHGWQEDKL
100

HR7616A-1-93-TEV
ELF3
P41970
ESAITLWQFLLQLLL
KFVYKFVSFPEILKM
92

HR4449C-1-93-TEV
ELK4
P28324
DSAITLWQFLLQLLQ
KFVYKFVSYPEILNM
92

HR8153A-249-313-Av6HT
EN2
P19622
TAFTAEQLQRLKAEF
IKKATGNKNTLAVHL
66

HR7174A-264-457-Av6HT
EOMES
O95936
GFRAHVYLCNRPLWL
LKIDHNPFAKGFRDN
194

HR4540F-1221-1288-14
EP300
Q09472
MQPQTTINKEQFSKR
GCLKKSARTRKENKF
69

HR4540F-1226-1281-14
EP300
Q09472
MINKEQFSKRKNDTL
PAGFVCDGCLKKSAR
57

HR4540F-1236-1281-14
EP300
Q09472
MNDTLDPELFVECTE
PAGFVCDGCLKKSAR
47

HR4540G-323-423-TEV
EP300
Q09472
GSGAHTADPEKRKLI
HDCPVCLPLKNAGDK
100

HR4540H-1045-1161-Av6HT
EP300
Q09472
KKKIFKPEELRQALM
EVFEQEIDPVMQSLG
117

HR4540I-1726-1817-Av6HT
EP300
Q09472
SPGDSRRLSIQRCIQ
VPFCLNIKQKLRQQQ
92

HR4540J-1135-1205-15
EP300
Q09472
MTSRVYKYCSKLSEV
YYSYQNRYHFCEKCF
72

HR4540J-1135-1220-15
EP300
Q09472
MTSRVYKYCSKLSEV
NEIQGESVSLGDDPS
87

HR4540J-1165-1205-15
EP300
Q09472
MGRKLEFSPQTLCCY
YYSYQNRYHFCEKCF
42

HR4540J-1165-1220-15
EP300
Q09472
MGRKLEFSPQTLCCY
NEIQGESVSLGDDPS
57

HR7040A-1285-1379-Av6HT
EP400
Q96L91
HVLKCRLSNRQKALY
RDFWKEADLSMFDLI
95

HR8188A-239-350-TEV
EPAS1
Q99814
LDSKTFLSRHSMDMK
CIMCVNYVLSEIEKN
112

HR6944A-8-123-Av6HT
ERF
P50548
GFAFPDWAYKPESSP
NKLVLVNYPFIDVGL
116

HR6944A-8-160-NHT
ERF
P50548
GFAFPDWAYKPESSP
PSTPSEVLSPTEDPR
153

HR6944B-24-123-Av6HT
ERF
P50548
SRQIQLWHFILELLR
NKLVLVNYPFIDVGL
109

HR6944B-24-160-Av6HT
ERF
P50548
SRQIQLWHFILELLR
PSTPSEVLSPTEDPR
137

HR4801B-180-254-TEV
ESR1
P03372
KETRYCAVCNDYASG
CRLRKGYEVGMMKGG
75

HR4685B-144-218-TEV
ESR2
Q92731
RDAHFCAVCSDYASG
CRLRKCYEVGMVKCG
75

HR7097A-77-146-15
ESRRA
P11474
MRLCLVCGDVASGYH
QACRFTKCLRVGMLK
71

HR7097A-77-146-Av6HT
ESRRA
P11474
RLCLVCGDVASGYHY
QACRFTKCLRVGMLK
70

HR7097A-77-146-TEV
ESRRA
P11474
RLCLVCGDVASGYHY
QACRFTKCLRVGMLK
70

HR7097A-77-168-15
ESRRA
P11474
MRLCLVCGDVASGYH
VRGGRQKYKRRPEVD
93

HR7097A-77-168-Av6HT
ESRRA
P11474
RLCLVCGDVASGYHY
VRGGRQKYKRRPEVD
92

HR7097A-77-168-TEV
ESRRA
P11474
RLCLVCGDVASGYHY
VRGGRQKYKRRPEVD
92

HR7097B-179-423-15
ESRRA
P11474
MGPLAVAGGPRKTAA
PMHKLFLEMLEAMMD
246

HR7097B-179-423-Av6HT
ESRRA
P11474
GPLAVAGGPRKTAAP
PMHKLFLEMLEAMMD
245

HR7097B-179-423-TEV
ESRRA
P11474
GPLAVAGGPRKTAAP
PMHKLFLEMLEAMMD
245

HR7097C-193-423-15
ESRRA
P11474
MPVNALVSHLLVVEP
PMHKLFLEMLEAMMD
232

HR7097C-193-423-Av6HT
ESRRA
P11474
PVNALVSHLLVVEPE
PMHKLFLEMLEAMMD
231

HR7097C-193-423-TEV
ESRRA
P11474
PVNALVSHLLVVEPE
PMHKLFLEMLEAMMD
231

HR8438A-101-433-15
ESRRB
O95718
MRLCLVCGDIASGYH
VPMHKLFLEMLEAKA
334

HR8438A-78-435-15
ESRRB
O95718
MDCASGIMEDSAIKC
MHKLFLEMLEAKAWA
359

HR8438B-169-433-15
ESRRB
O95718
MLKEGVRLDRVRGGR
VPMHKLFLEMLEAKA
266

HR8438B-182-433-15
ESRRB
O95718
MRQKYKRRLDSESSP
VPMHKLFLEMLEAKA
253

HR8438B-203-433-15
ESRRB
O95718
MPPAKKPLTKIVSYL
VPMHKLFLEMLEAKA
232

HR7566D-122-219-Av6HT
ESRRG
P62508
MSMPKRLCLVCGDIA
GGRQKYKRRIDAENS
99

HR7566D-122-219-TEV
ESRRG
P62508
SMPKRLCLVCGDIAS
GGRQKYKRRIDAENS
98

HR6900A-130-214-NHT
ESX1
Q8N693
AEGPQPPERKRRRRT
VLMLRNTATADLAHP
85

HR8013A-320-415-Av5HT
ETS1
P14921
VIPAAALAGYTGSGP
IIHKTAGKRYVYRFV
96

HR8013A-320-415-TEV
ETS1
P14921
VIPAAALAGYTGSGP
IIHKTAGKRYVYRFV
96

HR5529-1-329-15
ETS2
P15036
MNDFGIKNMDQVAPV
EDDCSQSLCLNKPTM
329

HR5529A-14
ETS2
P15036
MHDSANCELPLLTPC
EHLEQMIKENQEKTE
116

HR5529A-15
ETS2
P15036
MHDSANCELPLLTPC
EHLEQMIKENQEKTE
116

HR8505A-240-333-Av6HT
ETV2
O00321
IQLWQFLLELLHDGA
FGGRVPSLAYPDCAG
94

HR7364A-15-174-NHT
ETV3
P41162
GGYQFPDWAYKTESS
PTNDVQPGRFSASSL
160

HR6967A-1-136-NHT
ETV3L
Q6ZN32
HCSCLAEGIPANPGN
SKLIVVNYPLWEVRA
135

HR5533A-14
ETV4
P43268
MREGPPYQRRGALQL
QRPALKAEFDRPVSE
122

HR5533A-15
ETV4
P43268
MREGPPYQRRGALQL
QRPALKAEFDRPVSE
122

HR8084A-311-445-Av6HT
ETV4
P43268
CVVPEKFEGDIKQEG
AFPDNQRPALKAEFD
135

HR7423A-333-470-NHT
ETV5
P41161
LYFDDTCVVPERLEG
SMAFPDNQRPFLKAE
138

HR6884A-338-443-TEV
ETV6
P41212
CRLLWDYVYQLLSDS
GRTDRLEHLESQELD
106

HR6884B-47-129-TEV
ETV6
P41212
SIRLPAHLRLQPIYW
ELLQHILKQRKPRIL
83

HR7437A-8-133-NHT
ETV7
Q9Y603
ISPISPVAAMPPLGT
ALVCGPFFGGIFRLK
126

HR7509A-183-242-TEV
EVX1
P49640
RRYRTAFTREQIARL
KVWFQNRRMKDKRQR
59

HR7284A-188-247-TEV
EVX2
Q03828
VRRYRTAFTREQIAR
KVWFQNRRMKDKRQR
60

HR7802A-349-453-TEV
EWSR1
Q01844
PPVDPDEDSDNSAIY
LKVSLARKKPPMNSM
105

HR7511A-1-99-TEV
EXOC2
Q96KP1
SRSRQPPLVTGISPN
TSTVSFKLLKPEKIG
98

HR6516A-463-729-NHT
EZH1
Q92800
KTCKQVFQFAVKESL
RAIQAGEELFFDYRY
267

HR6323-214-746-14
EZH2
Q15910
PPRKFPSDKIFEAIS
DALKYVGIEREMEIP
533

HR7273-1-589-TEV
FARSB
Q9NSD9
PTVSVKRDLLFQALG
TMPCSSLEINVGPFL
588

HR8271C-2054-2125-NHT
FBN1
P35555
QDLRMSYCYAKFEGG
CPYGSGIIVGPDDSA
72

HR6868A-99-166-NHT
FERD3L
Q96RJ6
TYAQRQAANIRERKR
FMTELLESCEKKESG
68

HR6882A-43-139-TEV
FEV
Q99581
GSGQIQLWQFLLELL
RFDFQGLAQACQPPP
97

HR6968A-258-310-NHT
FEZF1
A0PJY2
KVFTCEVCGKVFNAH
GFRQASTLCRHKIIH
53

HR7661A-275-327-NHT
FEZF2
Q8TBJ5
KNFTCEVGGKVFNAH
GFRQASTLCRHKIIH
53

HR3605C-806-930-14
FGD1
P98174
MRRRSILEKQASVAA
LGRAGRGDTFCPGPT
126

HR3605C-811-925-14
FGD1
P98174
MLEKQASVAAENSVI
RWMAVLGRAGRGDTF
116

HR8434A-55-150-Av6HT
FIGLA
Q6QHK4
SSTENLQLVLERRRV
SYSNNSSESHTSSAR
96

HR8078A-77-129-Av6HT
FIZ1
Q96SL8
RPYRCSACPKGFRDS
RFSSRSSLGRHLKRQ
53

HR4739B-114-198-Av6HT
FLI1
Q01543
MPPNMTTNERRVIVP
TEVLLSHLSYLRESS
86

HR4739B-114-198-TEV
FLI1
Q01543
PPNMTTNERRVIVPA
TEVLLSHLSYLRESS
85

HR6395-41-355-15
FOS
P01100
MGSPVNAQDFCTDLA
FVFTYPEADSFPSCA
316

HR6395-41-361-15
FOS
P01100
MGSPVNAQDFCTDLA
EADSFPSCAAAHRKG
322

HR6395-46-350-15
FOS
P01100
MAQDFCTDLAVSSAN
AYTSSFVFTYPEADS
306

HR6395-46-361-15
FOS
P01100
MAQDFCTDLAVSSAN
EADSFPSCAAAHRKG
317

HR3160-41-293-15
FOSL2
P15408
MPGSGSAFIPTINAI
NLVFTYPSVLEQESP
254

HR3160-44-288-15
FOSL2
P15408
MGSAFIPTINAITTS
TPGTSNLVFTYPSVL
246

HR7662A-167-264-NHT
FOXA1
P55317
PHAKPPYSYISLITM
SGNMFENGCYLRRQK
98

HR7840A-114-211-NHT
FOXA3
P55318
AHAKPPYSYISLITM
SGNMFENGCYLRRQK
98

HR7656A-11-100-NHT
FOXB1
Q99853
DQKPPYSYISLTAMA
FWALHPSCGDMFENG
90

HR7565A-15-100-NHT
FOXB2
Q5VYV0
PYSYISLTAMAIQHS
FWALHPDCGDMFENG
86

HR8399A-76-168-TEV
FOXC1
Q12948
VKPPYSYIALITMAI
LDPDSYNMFENGSFL
92

HR6945A-70-162-TEV
FOXC2
Q99958
LVKPPYSYIALITMA
LDPDSYNMFENGSFL
93

HR8366A-126-222-NHT
FOXD2
O60548
VKPPYSYIALITMAI
ADMFDNGSFLRRRKR
97

HR8366A-126-222-TEV
FOXD2
O60548
VKPPYSYIALITMAI
ADMFDNGSFLRRRKR
97

HR7150A-140-236-Av6HT
FOXD3
Q9UJU5
VKPPYSYIALITMAI
EDMFDNGSFLRRRKR
97

HR7150A-140-236-TEV
FOXD3
Q9UJU5
VKPPYSYIALITMAI
EDMFDNGSFLRRRKR
97

HR7841A-104-204-TEV
FOXD4
Q12950
KPPSSYIALITMAIL
NGSFLRRRKRFQRHQ
101

HR6889A-107-207-TEV
FOXD4L1
Q9NU39
KPPSSYIALITMAIL
NGSFLRRRKRFKRHQ
101

HR8496-108-208-Av6HT
FOXD4L3
Q6VB84
KPPYSYIALITMAIL
NGSFLRRRKRFKRHQ
101

HR7982-108-208-Av6HT
FOXD4L4
Q6VB85
KPPYSYIALITMAIL
NGSFLRRRKRFKRHQ
101

HR7029A-108-208-TEV
FOXD4L5
Q5VV16
KPPYSYIALITMAIL
NGSFLRRRKRFKRHQ
101

HR7874-108-208-Av6HT
FOXD4L6
Q3SYB3
KPPYSYIALITMAIL
NGSFLRRRKRFKRHQ
101

HR5544A-14
FOXE1
O00358
MAGAGVPGEATGRGA
FLRRRKRFKRSDLST
131

HR5544A-15
FOXE1
O00358
MAGAGVPGEATGRGA
FLRRRKRFKRSDLST
131

HR6991A-51-146-NHT
FOXE1
O00358
RGKPPYSYIALIAMA
NAEDMFESGSFLRRR
96

HR7179A-69-165-NHT
FOXE3
Q13461
RGKPPYSYIALIAMA
AADMFDNGSFLRRRK
97

HR8233A-48-138-15
FOXF1
Q12946
MKPPYSYIALIVMAI
IDPASEFMFEEGSFR
92

HR8233A-48-138-Av6HT
FOXF1
Q12946
KPPYSYIALIVMAIQ
IDPASEFMFEEGSFR
91

HR7975A-101-190-Av6HT
FOXF2
Q12947
PPYSYIALIVMAIQS
IDPASEFMFEEGSFR
90

HR4505B-182-298-14
FOXG1
P55316
PPFSYNALIMMAIRQ
LAFKRGARLTSTGLT
117

HR4505B-183-294-14
FOXG1
P55316
PFSYNALIMMAIRQS
SRAKLAFKRGARLTS
112

HR4505C-183-276-Av6HT
FOXG1
P55316
PFSYNALIMMAIRQS
DDVFIGGTTGKLRRR
94

HR5526A-14
FOXH1
O75593
MYLRHDKPPYTYLAM
RLQNTALCRRWQNGG
109

HR5526A-15
FOXH1
O75593
MYLRHDKPPYTYLAM
RLQNTALCRRWQNGG
109

HR8014A-138-239-Av6HT
FOXI3
A8MTJ6
EDLMKMVRPPYSYSA
CEKMFDNGNFRRKRK
102

HR6903A-121-211-NHT
FOXJ1
Q92949
KPPYSYATLICMAMQ
IDPQYAERLLSGAFK
91

HR8000A-64-153-Av6HT
FOXJ2
Q9P0K8
DGKPRYSYATLITYA
YWTIDTCPDISRKRR
90

HR7453A-82-173-NHT
FOXJ3
Q9UPW0
SYASLITFAINSSPK
KEDVLPTRPKKRARS
92

HR7148A-303-403-TEV
FOXK1
P85037
ESKPPFSYAQLIVQA
LVEQAFRKRRQRGVS
101

HR8426A-256-353-Av6HT
FOXK2
Q01167
MDSKPPYSYAQLIVQ
ESKLIEQAFRKRRPR
99

HR8426A-256-353-TEV
FOXK2
Q01167
DSKPPYSYAQLIVQA
ESKLIEQAFRKRRPR
98

HR8426B-34-133-Av6HT
FOXK2
Q01167
GWAVARLEGREFEYL
NGVFVDGVFQRRGAP
100

HR8426B-34-153-Av6HT
FOXK2
Q01167
GWAVARLEGREFEYL
RVCTFRFPSTNIKIT
120

HR8426B-58-139-TEV
FOXK2
Q01167
RNSSQGSVDVSMGHS
GVFQRRGAPPLQLPR
82

HR8426B-58-143-TEV
FOXK2
Q01167
RNSSQGSVDVSMGHS
RRGAPPLQLPRVCTF
86

HR8426B-63-133-TEV
FOXK2
Q01167
GSVDVSMGHSSFISR
NGVFVDGVFQRRGAP
71

HR8426B-63-139-TEV
FOXK2
Q01167
GSVDVSMGHSSFISR
GVFQRRGAPPLQLPR
77

HR8426B-63-153-Av6HT
FOXK2
Q01167
GSVDVSMGHSSFISR
RVCTFRFPSTNIKIT
91

HR8426B-70-133-Av6HT
FOXK2
Q01167
GHSSFISRRHLEIFT
NGVFVDGVFQRRGAP
64

HR8426B-70-153-Av6HT
FOXK2
Q01167
GHSSFISRRHLEIFT
RVCTFRFPSTNIKIT
84

HR7608A-10-139-Av6HT
FOXL1
Q12952
PALAASPMLYLYGPE
LDPRCLDMFENGNYR
130

HR7608A-43-139-15
FOXL1
Q12952
MRAETPQKPPYSYIA
LDPRCLDMFENGNYR
98

HR7608A-48-111-15
FOXL1
Q12952
MQKPPYSYIALIAMA
IRHNLSLNDCFVKVP
65

HR7608A-48-139-15
FOXL1
Q12952
MQKPPYSYIALIAMA
LDPRCLDMFENGNYR
93

HR7608B-10-134-Av6HT
FOXL1
Q12952
PALAASPMLYLYGPE
GSYWTLDPRCLDMFE
125

HR7608B-50-164-Av6HT
FOXL1
Q12952
PPYSYIALIAMAIQD
GAPEAKRPRAETHQR
115

HR7161A-56-143-NHT
FOXL2
P58012
PYSYVALIAMAIRES
TLDPACEDMFEKGNY
88

HR6909A-222-360-Av6HT
FOXM1
Q08050
MPSRPSASWQNSVSE
NPELRRNMTIKTELP
140

HR6909A-222-360-TEV
FOXM1
Q08050
PSRPSASWQNSVSER
NPELRRNMTIKTELP
139

HR7300A-268-368-NHT
FOXN1
Q15353
LFPKPIYSYSILIFM
DKMQEELQKWKRKDP
101

HR7988A-110-208-Av6HT
FOXN2
P32314
TSKPPYSFSLLIYMA
KPNLIQALKKQPFSS
99

HR6979A-111-207-NHT
FOXN3
Q00409
PNCKPPYSFSCLIFM
PEYRQNLIQALKKTP
97

HR7465A-193-285-NHT
FOXN4
Q96NZ1
KPIYSYSCLIAMALK
NLARIDKMEEEMHKW
93

HR4552B-151-249-TEV
FOXO1
Q12778
KSSSSRRNAWGNLSY
SWWMLNPEGGKSGKS
99

HR5548A-14
FOXO1
Q12778
MPPAAAGPLAGQPRK
SKFAKSRSRAAKKKA
139

HR5548A-15
FOXO1
Q12778
MPPAAAGPLAGQPRK
SKFAKSRSRAAKKKA
139

HR5549A-14
FOXO3
O43524
MLPPPQPGAAGGSGQ
NKYTKSRGRAAKKKA
141

HR5549A-15
FOXO3
O43524
MLPPPQPGAAGGSGQ
NKYTKSRGRAAKKKA
141

HR4610C-102-197-TEV
FOXO4
P98177
GNQSYAELISQAIES
EGGKSGKAPRRRAAS
96

HR7590A-462-548-TEV
FOXP1
Q9H334
AEVRPPFTYASLIRQ
WTVDEVEFQKRRPQK
87

HR7934A-501-587-TEV
FOXP2
O15409
DVRPPFTYATLIRQA
TVDEVEYQKRRSQKI
87

HR6897A-464-550-TEV
FOXP4
Q8IVH2
ADVRPPFTYASLIRQ
WTVDEREYQKRRPPK
87

HR8323A-118-217-NHT
FOXQ1
Q9C009
PKPPYSYIALIAMAI
TFADGVFRRRRKRLS
100

HR8323A-118-217-TEV
FOXQ1
Q9C009
PKPPYSYIALIAMAI
TFADGVFRRRRKRLS
100

HR7058A-170-271-NHT
FOXR1
Q6PIV2
LWSRPPLNYFHLIAL
GHRRFAEEARALAST
102

HR8252A-189-311-Av6HT
FOXR2
Q6PJQ5
SWQRPPLNCSHLIAL
ECMSQPELLTSLFDL
123

HR7804A-20-110-NHT
FOXS1
O43638
PYSYIALIAMAIQSS
PDCHDMFEHGSFLRR
91

HR8359A-35-121-TEV
GABPA
Q06546
AECVSQAIDINEPIG
KLNILEIVKPADTVE
87

HR7128A-251-311-TEV
GATA1
P15976
SKRAGTQCTNCQTTT
MRKDGIQTRNRKASG
61

HR4414D-340-402-TEV
GATA2
P23769
SAARRAGTCCANCQT
MKKEGIQTRNRKMSN
63

HR7641A-308-370-TEV
GATA3
P23771
LSAARRAGTSCANCQ
TMKKEGIQTRNRKMS
63

HR4783B-262-321-TEV
GATA4
P43694
SASRRVGLSCANCQT
PLAMRKEGIQTRKRK
60

HR8231A-242-324-15
GBX1
Q14549
MTGAEEGAPVTAGVT
QNRRAKWKRIKAGNV
84

HR8231A-242-324-Av6HT
GBX1
Q14549
TGAEEGAPVTAGVTA
QNRRAKWKRIKAGNV
83

HR6959A-1-173-TEV
GCM1
Q9NP62
EPDDFDSEDKEILSW
TKLEAEARRAMKKVN
172

HR8430A-6-165-Av6HT
GCM2
O75603
VQEAVGVCSYGMQLS
FQAKGVHDHPRPESK
160

HR4429D-233-303-14
GFI1
Q99684
MKGAGVKVESELLCT
CGKTFGHAVSLEQHK
72

HR4429D-233-315-14
GFI1
Q99684
MKGAGVKVESELLCT
QHKAVHSQERSFDCK
84

HR4429D-238-298-14
GFI1
Q99684
MKVESELLCTRLLLG
FACEMCGKTFGHAVS
62

HR4429D-238-310-14
GFI1
Q99684
MKVESELLCTRLLLG
AVSLEQHKAVHSQER
74

HR4429E-311-392-TEV
GFI1
Q99684
SFDCKICGKSFKRSS
SQSSNLITHSRKHTG
82

HR7937A-234-388-TEV
GLI1
P08151
YVCKLPGCTKRYTDP
RLDQLHQLRPIGTRG
155

HR7924A-436-590-TEV
GLI2
P10070
ETNCHWEDCTKEYDT
TDPSSLRKHVKTVHG
155

HR7118A-479-633-TEV
GLI3
P10071
ETNCHWEGCAREFDT
TDPSSLRKHVKTVHG
155

HR7155A-189-350-NHT
GLIS1
Q8NBF1
RVVAGRQACRWVDCC
PSSLRKHVKAHSAKE
162

HR7416A-116-298-Av6HT
GLIS2
Q9BZE0
DFQPLRYLDGVPSSF
TRTHYVDKPYYCKMP
183

HR7416A-116-318-Av6HT
GLIS2
Q9BZE0
DFQPLRYLDGVPSSF
YTDPSSLRKHIKAHG
203

HR7416A-150-318-Av6HT
GLIS2
Q9BZE0
LTPPKDKCLSPDLPL
YTDPSSLRKHIKAHG
169

HR7416A-163-298-Av6HT
GLIS2
Q9BZE0
PLPKQLVCRWAKCNQ
TRTHYVDKPYYCKMP
136

HR7416A-163-318-Av6HT
GLIS2
Q9BZE0
PLPKQLVCRWAKCNQ
YTDPSSLRKHIKAHG
156

HR7200A-261-553-TEV
GLYR1
Q49A26
GSITPTDKKIGFLGL
QSDNDMSAVYRAYIH
293

HR7763A-87-182-TEV
GMEB1
Q9Y692
ANEDMEIAYPITCGE
YQHDKVCSNTCRSTK
96

HR7418A-64-203-NHT
GMEB2
Q9UKD1
AFTASSQLKEAVLVK
LSSPTSAEYIPLTPA
140

HR7418A-87-176-Av6HT
GMEB2
Q9UKD1
EAEIVYPITCGDSRA
LDFYQHDKVCSNTCR
90

HR7418A-87-203-Av6HT
GMEB2
Q9UKD1
EAEIVYPITCGDSRA
LSSPTSAEYIPLTPA
117

HR7418B-64-179-Av6HT
GMEB2
Q9UKD1
AFTASSQLKEAVLVK
YQHDKVCSNTCRSTK
116

HR7418B-83-179-Av6HT
GMEB2
Q9UKD1
GENLEAEIVYPITCG
YQHDKVCSNTCRSTK
97

HR7418B-83-203-Av6HT
GMEB2
Q9UKD1
GENLEAEIVYPITCG
LSSPTSAEYIPLTPA
121

HR8221A-2125-2211-NHT
GON4L
Q3T8J9
PEGEQQPKAAEATVC
RELMQLFHTACEASS
87

HR7528A-714-848-NHT
GPR155
Q7Z3F1
DKHLIILPFKRRLEF
LQKSPEQSPPAINAN
135

HR7997A-174-442-Av6HT
GRHL1
Q9NZI5
VYHPEPTERVVVFDR
KIRDEERKQSKRKVS
269

HR7758A-219-444-Av6HT
GRHL2
Q6ISB3
SFKDAATEKFRSASV
RKQNRKKGKGQASQT
226

HR7267A-161-223-TEV
GSC
P56915
RRHRTIFTDEQLEAL
KNRRAKWRRQKRSSS
63

HR8103A-123-177-Av6HT
GSC2
O15499
QRRTRRHRTIFSEEQ
IRLREERVEVWFKNR
55

HR7705A-139-207-NHT
GSX1
Q9H4S2
SSSNQLPSSKRMRTA
IWFQNRRVKHKKEGK
69

HR8308A-66-146-TEV
GTF2E2
P29084
ALSGSSGYKFGVLAK
VIDGKYAFKPKYNVR
81

HR8128A-449-517-Av6HT
GTF2F1
P35269
SGDVQVTEDAVRRYL
ERKMINDKMHFSLKE
69

HR8128A-449-517-TEV
GTF2F1
P35269
SGDVQVTEDAVRRYL
ERKMINDKMHFSLKE
69

HR7967A-175-243-TEV
GTF2F2
P13984
RARADKQHVLDMLFS
HKNTWELKPEYRHYQ
69

HR7205-1-238-15
GTF2H2C
Q6P1K8
MDEEPERTKRWEGGY
DESHYKELLTHHLSP
238

HR7205-1-327-15
GTF2H2C
Q6P1K8
MDEEPERTKRWEGGY
VSAPHLARSYHHLFP
327

HR7205-1-332-15
GTF2H2C
Q6P1K8
MDEEPERTKRWEGGY
LARSYHHLFPLDAFQ
332

HR7205-10-327-15
GTF2H2C
Q6P1K8
MRWEGGYERTWEILK
VSAPHLARSYHHLFP
319

HR7205-10-395-15
GTF2H2C
Q6P1K8
MRWEGGYERTWEILK
CCPGCIHKIPAPSGV
387

HR7205-15
GTF2H2C
Q6P1K8
MDEEPERTKRWEGGY
CPGCIHKIPAPSGV*
396

HR7205A-328-386-TEV
GTF2H2C
Q6P1K8
LDAFQEIPLEEYNGE
DVFVHDSLHCCPGCI
59

HR7205B-10-216-15
GTF2H2C
Q6P1K8
MRWEGGYERTWEILK
SAEVRVCTVLARETG
208

HR7205B-48-220-15
GTF2H2C
Q6P1K8
MEHHGQVRLGMMRHL
RVCTVLARETGGTYH
174

HR7205B-48-238-15
GTF2H2C
Q6P1K8
MEHHGQVRLGMMRHL
DESHYKELLTHHLSP
192

HR7205B-53-216-15
GTF2H2C
Q6P1K8
MVRLGMMRHLYVVVD
SAEVRVCTVLARETG
165

HR7205B-53-236-15
GTF2H2C
Q6P1K8
MVRLGMMRHLYVVVD
ILDESHYKELLTHHL
185

HR7205C-1-216-TEV
GTF2H2C
Q6P1K8
DEEPERTKRWEGGYE
SAEVRVCTVLARETG
215

HR7205C-1-255-TEV
GTF2H2C
Q6P1K8
DEEPERTKRWEGGYE
ASSSSECSLIRMGFP
254

HR7205C-10-236-TEV
GTF2H2C
Q6P1K8
RWEGGYERTWEILKE
ILDESHYKELLTHHL
227

HR7205C-10-255-TEV
GTF2H2C
Q6P1K8
RWEGGYERTWEILKE
ASSSSECSLIRMGFP
246

HR7820A-107-194-TEV
GTF2IRD2
Q86UP8
LRKAVEDYFCFCYGK
NRPFLGPESQLGGPG
88

HR7355A-318-415-TEV
GTF2IRD2B
Q6EKJ0
NEKERLSSIEKIKQL
KFTVIRPLPGLELSN
98

HR7357A-130-188-NHT
GTF3A
Q92664
KQYICSFEDCKKTFK
ASPSKLKRHAKAHEG
59

HR7579A-1-143-NHT
GZF1
Q9H116
ESGAVLLESKSSPFN
KKQMLESVLLELQNF
142

HR7057A-44-107-Av6HT
H1FX
Q92522
QPGKYSQLVVETIRR
IKALVQNDTLLQVKG
64

HR7057A-44-123-Av6HT
H1FX
Q92522
QPGKYSQLVVETIRR
GANGSFKLNRKKLEG
80

HR7057A-61-123-Av6HT
H1FX
Q92522
ERNGSSLAKIYTEAK
GANGSFKLNRKKLEG
63

HR4599B-103-162-14
HAND2
P61296
MTANRKERRRTQSIN
IAYLMDLLAKDDQNG
61

HR4798B-422-503-TEV
HBP1
Q50381
SSGTVSATSPNKCKR
ALAEEQKRLNPDCWK
82

HR7788A-435-507-TEV
HDX
Q7Z353
KYRLMGIEVPPPRGG
SSQEEPNEVVPNDAR
73

HR7299A-109-148-Av6HT
HES1
Q14469
KYRAGFSECMNEVTR
EVRTRLLGHLANCMT
40

HR7299A-109-153-Av6HT
HES1
Q14469
KYRAGFSECMNEVTR
LLGHLANCMTQINAM
45

HR7306A-7-75-NHT
HES2
Q9Y543
AGDAAELRKSLKPLL
EMTVRFLQELPASSW
69

HR8387-1-122-Av6HT
HES3
Q5TGS1
EKKRRARINVSLEQL
GLGQEAPALFRPCTP
121

HR6986-1-108-TEV
HES5
Q5TA89
APSTVAVELLSPKEK
WCLQEAVQFLTLHAA
107

HR6986-1-122-TEV
HES5
Q5TA89
APSTVAVELLSPKEK
ASDTQMKLLYHFQRP
121

HR6986-49-166-TEV
HES5
Q5TA89
RHQPNSKLEKADILE
AAAAHQPACGLWRPW
118

HR6986A-11-108-Av6HT
HES5
Q5TA89
LSPKEKNRLRKPVVE
WCLQEAVQFLTLHAA
98

HR6986A-11-80-Av6HT
HES5
Q5TA89
LSPKEKNRLRKPVVE
VSYLKHSKAFVAAAG
70

HR6986A-21-108-Av6HT
HES5
Q5TA89
KPVVEKMRRDRINSS
WCLQEAVQFLTLHAA
88

HR6986A-25-108-Av6HT
HES5
Q5TA89
EKMRRDRINSSIEQL
WCLQEAVQFLTLHAA
84

HR6872A-108-174-TEV
HESX1
Q9UBX0
GRRPRTAFTQNQIEV
RAKLKRSHRESQFLM
67

HR7863A-111-167-TEV
HEY1
Q9Y5J3
AGGKGYFDAHALAMD
PLRVRLVSHLNNYAS
57

HR7070A-110-166-TEV
HEY2
Q9UBP5
GYFDAHALAMDFMSI
RLVSHLSTCATQREA
57

HR7572A-104-158-15
HEYL
Q9NQ87
MTGFFDARALAVDFR
PVRIRLLSHLNSYAA
56

HR7572A-77-163-15
HEYL
Q9NQ87
MQGSSKLEKAEVLQM
LLSHLNSYAAEMEPS
88

HR7572A-82-158-15
HEYL
Q9NQ87
MLEKAEVLQMTVDHL
PVRIRLLSHLNSYAA
78

HR7851A-138-194-Av6HT
HHEX
Q03014
MKGGQVRFSNDQTIE
QVKTWFQNRRAKWRR
58

HR7851A-138-194-TEV
HHEX
Q03014
KGGQVRFSNDQTIEL
QVKTWFQNRRAKWRR
57

HR7402A-1-153-NHT
HIC1
Q14526
TFPEADILLKSGECA
PDLVALCKKRLKRHG
152

HR7195A-20-139-NHT
HIC2
Q96JB3
GPDMELPSHSKQLLL
YLQLPELAALCRRKL
120

HR3603B-775-826-TEV
HIF1A
Q16665
PSDLACRLLGQSMDE
LLQGEELLRALDQVN
52

HR7384A-39-112-TEV
HIST1H1A
Q02339
AGPSVSELIVQAASS
QTKGTGASGSFKLNK
74

HR7165A-40-112-TEV
HIST1H1B
P16401
GPPVSELITKAVAAS
QTKGTGASGSFKLNK
73

HR7583A-36-109-TEV
HIST1H1C
P16403
SGPPVSELITKAVAA
QTKGTGASGSFKLNK
74

HR7583A-37-110-TEV
HIST1H1C
P16403
GPPVSELITKAVAAS
TKGTGASGSFKLNKK
74

HR8248A-2087-2143-TEV
HIVEP1
P15822
KYICEECGIRCKKPS
GNLTKHMKSKAHSKK
57

HR7166A-1798-1854-TEV
HIVEP2
P31629
KYICEECGIRCKKPS
GNLTKHMKSKAHMKK
57

HR7042A-1753-1809-TEV
HIVEP3
Q5T1R4
KYVCEECGIRCKKPS
GNLTKHMKSKAHSKK
57

HR7786A-523-577-NHT
HKR1
P10072
KPFVCAECGRGFNDK
RQKPNLFRHKRAHSG
55

HR7711A-33-224-TEV
HLA-DQB1
P01920
RDSPEDFVFQFKGMC
PSLQSPITVEWRAQS
192

HR7053A-30-228-TEV
HLA-DRB1
P01911
GDTRPRFLWQPKREC
TVEWRARSESAQSKM
199

HR8520A-30-221-TEV
HLA-DRB1
P04229
GDTRPRFLWQLKFEC
PSVTSPLTVEWRARS
192

HR7721A-30-219-TEV
HLA-DRB3
P79483
GDTRPRFLELRKSEC
EHPSVTSALTVEWRA
190

HR7380A-30-221-TEV
HLA-DRB5
Q30154
GDTRPRFLQQDKYEC
PSVTSPLTVEWRAQS
192

HR7352A-219-295-TEV
HLF
Q16534
IPDDLKDDKYWARRR
CKNILAKYEARHGPL
77

HR8006A-269-334-Av6HT
HLX
Q14774
PQTYKRKRSWSRAVF
VKVWFQNRRMKWRHS
66

HR7519A-268-352-TEV
HMBOX1
Q6NT76
RGSRFTWRKECLAVM
KRRANIEAAILESHG
85

HR1506-15
HMG20A
Q9NP66
MENLMTSSTLPPLFA
SSNAAEGNEQRHEDE
79

HR1506-15.2wt
HMG20A
Q9NP66
MENLMTSSTLPPLFA
SSNAAEGNEQRHEDE
79

HR7093A-68-149-TEV
HMG20B
Q9P0W2
NGPKAPVTGYVRFLN
RAYQQSEAYKMCTEK
82

HR7828-30
HMGB1
P09429
MGKGDPKKPRGKMSS
EDEEDEDEEEDDDDE
215

HR7828A-8-78-Av6HT
HMGB1
P09429
KPRGKMSSYAFFVQT
AKADKARYEREMKTY
71

HR7828A-8-78-TEV
HMGB1
P09429
KPRGKMSSYAFFVQT
AKADKARYEREMKTY
71

HR7828B-30
HMGB1
P09429
KKKFKDPNAPKRPPS
LKEKYEKDIAAYRAK
80

HR8516A-8-78-TEV
HMGB1P1
B2RPK0
KPRGKMSSYAFFVQT
AKADKTHYERQMKTY
71

HR8015A-1-77-Av6HT
HMGB2
P26583
MGKGDPNKPRGKMSS
MAKSDKARYDREMKN
77

HR8015A-1-77-TEV
HMGB2
P26583
GKGDPNKPRGKMSSY
MAKSDKARYDREMKN
76

HR8319A-1-79-TEV
HMGB3
Q15347
AKGDPKKPKGKMSAY
KADKVRYDREMKDYG
78

HR8540A-11-186-Av6HT
HMGB4
Q8WW32
ANVSSYVHFLLNYRN
MSARNRCRGKRVRQS
176

HR7956-381-466-Av6HT
HMGXB4
Q9UGU5
LHTDGHSEKKKKKEE
DKLIWKQKAQYLQHK
86

HR7411A-1-264-TEV
HMOX2
P30519
SAEVETSEGVDESEK
EDGFPVHDGKGDMRK
263

HR7000A-188-261-NHT
HMX1
Q9NP08
AAGETRGGVGVGGGR
VKIWFQNRRNKWKRQ
74

HR8029A-131-216-Av6HT
HMX2
A2RU54
PGSERPRDGGAERQA
NKWKRQLSAELEAAN
86

HR6871A-218-296-NHT
HMX3
A6NHT5
SPEKKPACRKKKTRT
WKRQLAAELEAANLS
79

HR8251A-233-325-NHT
HNF1B
P35680
RNRFKWGPASQQILY
QKLAMDAYSSNQTHS
93

HR8251A-233-325-TEV
HNF1B
P35680
RNRFKWGPASQQILY
QKLAMDAYSSNQTHS
93

HR7522A-142-391-15
HNF4A
P41235
MSSYEDSSLPSINAL
GSPSDAPHAHHPLHP
251

HR7522A-142-391-Av6HT
HNF4A
P41235
SSYEDSSLPSINALL
GSPSDAPHAHHPLHP
250

HR7522A-142-391-TEV
HNF4A
P41235
SSYEDSSLPSINALL
GSPSDAPHAHHPLHP
250

HR7522B-142-378-15
HNF4A
P41235
MSSYEDSSLPSINAL
AKIDNLLQEMLLGGS
238

HR7522B-142-378-Av6HT
HNF4A
P41235
SSYEDSSLPSINALL
AKIDNLLQEMLLGGS
237

HR7522B-142-378-TEV
HNF4A
P41235
SSYEDSSLPSINALL
AKIDNLLQEMLLGGS
237

HR7522C-148-377-15
HNF4A
P41235
MSLPSINALLQAEVL
MAKIDNLLQEMLLGG
231

HR7522C-148-377-Av6HT
HNF4A
P41235
SLPSINALLQAEVLS
MAKIDNLLQEMLLGG
230

HR7522C-148-377-TEV
HNF4A
P41235
SLPSINALLQAEVLS
MAKIDNLLQEMLLGG
230

HR7522D-58-135-15
HNF4A
P41235
MALCAICGDRATGKH
FRAGMKKEAVQNERD
79

HR7522D-58-135-Av6HT
HNF4A
P41235
ALCAICGDRATGKHY
FRAGMKKEAVQNERD
78

HR7522D-58-135-TEV
HNF4A
P41235
ALCAICGDRATGKHY
FRAGMKKEAVQNERD
78

HR7469A-9-77-15
HNF4G
Q14541
MVLDPTYTTLEFETM
ASSCDGCKGFFRRSI
70

HR7469A-9-91-15
HNF4G
Q14541
MVLDPTYTTLEFETM
IRKSHVYSCRFSRQC
84

HR7469A-9-91-Av6HT
HNF4G
Q14541
VLDPTYTTLEFETMQ
IRKSHVYSCRFSRQC
83

HR7469A-9-91-TEV
HNF4G
Q14541
VLDPTYTTLEFETMQ
IRKSHVYSCRFSRQC
83

HR7469A-9-95-15
HNF4G
Q14541
MVLDPTYTTLEFETM
HVYSCRFSRQCVVDK
88

HR7469A-9-95-Av6HT
HNF4G
Q14541
VLDPTYTTLEFETMQ
HVYSCRFSRQCVVDK
87

HR7469A-9-95-TEV
HNF4G
Q14541
VLDPTYTTLEFETMQ
HVYSCRFSRQCVVDK
87

HR7469B-103-328-15
HNF4G
Q14541
MYCRLRKCFRAGMKK
RQYDSRGRFGELLLL
227

HR7469B-103-328-Av6HT
HNF4G
Q14541
YCRLRKCFRAGMKKE
RQYDSRGRFGELLLL
226

HR7469B-103-328-TEV
HNF4G
Q14541
YCRLRKCFRAGMKKE
RQYDSRGRFGELLLL
226

HR8063A-429-485-TEV
HOMEZ
Q8IX15
SFQDPAIPTPPPSTR
AAHQQLRETDIPQLS
57

HR6881-1-73-TEV
HOPX
Q9BPY8
SAETASGPTEDQVEI
RRSEGLPSECRSVTD
72

HR7310A-197-291-TEV
HOXA1
P49639
ETSSPAQTFDWMKVK
FQNRRMKQKKREKEG
95

HR4742B-299-369-14
HOXA10
P31260
MKDSLGNSKGENAAN
SVHLTDRQVKIWFQN
72

HR4742B-299-393-14
HOXA10
P31260
MKDSLGNSKGENAAN
RENRIRELTANFNFS
96

HR4742C-309-369-14
HOXA10
P31260
MNAANWLTAKSGRKK
SVHLTDRQVKIWFQN
62

HR4742C-314-393-14
HOXA10
P31260
MLTAKSGRKKRCPYT
RENRIRELTANFNFS
81

HR4742C-320-393-14
HOXA10
P31260
MRKKRCPYTKHQTLE
RENRIRELTANFNFS
75

HR8427A-342-397-Av6HT
HOXA10
P31260
PYTKHQTLELEKEFL
WFQNRRMKLKKMNRE
56

HR8104A-227-302-Av6HT
HOXA11
P31270
GHTEDKAGGSSGQRT
WFQNRRMKEKKINRD
76

HR8104A-227-313-Av6HT
HOXA11
P31270
GHTEDKAGGSSGQRT
INRDRLQYYSANPLL
87

HR8104B-227-296-Av6HT
HOXA11
P31270
GHTEDKAGGSSGQRT
DRQVKIWFQNRRMKE
70

HR7749A-317-379-TEV
HOXA13
P31271
SSYRRGRKKRVPYTK
QVTIWFQNRRVKEKK
63

HR7478A-131-205-NHT
HOXA2
O43364
ESLEIADGSGGGSRR
FQNRRMKHKRQTQCK
75

HR7187A-190-266-Av6HT
HOXA3
O43365
SSKRARTAYTSAQLV
GKGMLTSSGGQSPSR
77

HR7193A-222-275-TEV
HOXA4
Q00056
YTRQQVLELEKEFHF
IWFQNRRMKWKKDHK
54

HR7149A-201-257-TEV
HOXA5
P20719
AYTRYQTLELEKEFH
FQNRRMKWKKDNKLK
57

HR7149A-202-258-TEV
HOXA5
P20719
YTRYQTLELEKEFHF
QNRRMKWKKDNKLKS
57

HR7925A-156-215-TEV
HOXA6
P31267
RRGRQTYTRYQTLEL
IWFQNRRMKWKKENK
60

HR4674B-194-270-TEV
HOXA9
P31269
NNPAANWLHARSTRK
NRRMKMKKINKDRAK
77

HR8367A-171-266-TEV
HOXB1
P14653
EPNTPTARTFDWMKV
QNRRMKQKKREREEG
96

HR8236A-216-273-TEV
HOXB13
Q92826
GRKKRIPYSKGQLRE
QITIWFQNRRVKEKK
58

HR7791A-149-216-Av6HT
HOXB2
P14652
AYTNTQLLELEKEFH
TQHREPPDGEPACPG
68

HR8135A-187-244-Av6HT
HOXB3
P14651
ASKRARTAYTSAQLV
RQIKIWFQNRRMKYK
58

HR8135A-196-252-Av6HT
HOXB3
P14651
TSAQLVELEKEFHFN
NRRMKYKKDQKAKGL
57

HR8135B-179-239-Av6HT
HOXB3
P14651
DKSPPGSAASKRART
LNLSERQIKIWFQNR
61

HR8135B-179-244-Av6HT
HOXB3
P14651
DKSPPGSAASKRART
RQIKIWFQNRRMKYK
66

HR8335A-169-222-Av6HT
HOXB4
P17483
MYTRQQVLELEKEFH
IWFQNRRMKWKKDHK
55

HR8335A-169-222-NHT
HOXB4
P17483
YTRQQVLELEKEFHY
IWFQNRRMKWKKDHK
54

HR8335A-169-222-TEV
HOXB4
P17483
YTRQQVLELEKEFHY
IWFQNRRMKWKKDHK
54

HR8261-201-257-Av6HT
HOXB5
P09067
YTRYQTLELEKEFHF
QNRRMKWKKDNKLKS
57

HR7319A-147-206-Av6HT
HOXB6
P17509
MRRGRQTYTRYQTLE
IWFQNRRMKWKKESK
61

HR7319A-147-206-TEV
HOXB6
P17509
RRGRQTYTRYQTLEL
IWFQNRRMKWKKESK
60

HR8504A-143-202-TEV
HOXB7
P09629
TYTRYQTLELEKEFH
RRMKWKKENKTAGPG
60

HR7846A-146-205-TEV
HOXB8
P17481
RRRGRQTYSRYQTLE
KIWFQNRRMKWKKEN
60

HR7230A-174-249-TEV
HOXB9
P17482
NPSANWLHARSSRKK
NRRMKMKKMNKEQGK
76

HR4478B-250-312-14
HOXC10
Q9NYD6
MKEEIKAENTTGNWL
RLEISKTINLTDRQV
64

HR4478B-255-342-14
HOXC10
Q9NYD6
MAENTTGNWLTAKSG
RENRIRELTSNFNFT
89

HR4478B-263-312-14
HOXC10
Q9NYD6
MLTAKSGRKKRCPYT
RLEISKTINLTDRQV
51

HR4478B-268-342-14
HOXC10
Q9NYD6
MGRKKRCPYTKHQTL
RENRIRELTSNFNFT
76

HR4478C-247-342-14
HOXC10
Q9NYD6
MNEAKEEIKAENTTG
RENRIRELTSNFNFT
97

HR7286A-240-304-Av6HT
HOXC11
O43248
SKFQIRELEREFFFN
LSRDRLQYFSGNPLL
65

HR7847A-205-271-NHT
HOXC12
P31275
APWYPINSRSRKKRK
QVKIWFQNRRMKKKR
67

HR7251A-255-316-Av6HT
HOXC13
P31276
SSYRRGRKKRVPYTK
RQVTIWFQNRRVKEK
62

HR8257A-163-216-NHT
HOXC4
P09017
YTRQQVLELEKEFHY
IWFQNRRMKWKKDHR
54

HR8257A-163-216-TEV
HOXC4
P09017
YTRQQVLELEKEFHY
IWFQNRRMKWKKDHR
54

HR7011A-156-219-TEV
HOXC5
Q00444
KRSRTSYTRYQTLEL
NRRMKWKKDSKMKSK
64

HR7839A-148-201-TEV
HOXC6
P09630
YSRYQTLELEKEFHF
IWFQNRRMKWKKESN
54

HR6394A-149-208-TEV
HOXC8
P31273
RRSGRQTYSRYQTLE
KIWFQNRRMKWKKEN
60

HR7283A-180-255-TEV
HOXC9
P31274
SNPVANWIHARSTRK
QNRRMKMKKMNKEKT
76

HR8256A-200-280-Av6HT
HOXD1
Q9GZZ0
AAFSTFEWMKVKRNA
LHLNDTQVKIWFQNR
81

HR8148A-269-340-15
HOXD10
P28358
MKRCPYTKHQTLELE
RENRIRELTANLTFS
73

HR8148A-274-327-Av6HT
HOXD10
P28358
TKHQTLELEKEFLFN
WFQNRRMKLKKMSRE
54

HR8148A-274-340-15
HOXD10
P28358
MTKHQTLELEKEELF
RENRIRELTANLTFS
68

HR8017A-257-326-Av6HT
HOXD11
P31277
SSSAVAPQRSRKKRC
IWFQNRRMKEKKLNR
70

HR7443A-276-333-TEV
HOXD13
P35453
GRKKRVPYTKLQLKE
QVTIWFQNRRVKDKK
58

HR7220A-181-257-Av6HT
HOXD3
P31249
GESCEDKSPPGPASK
QNRRMKYKKDQKAKG
77

HR7700A-161-220-TEV
HOXD4
P09016
YTRQQVLELEKEFHF
RMKWKKDHKLPNTKG
60

HR7832A-197-256-TEV
HOXD8
P13378
RRRGRQTYSRFQTLE
KIWFQNRRMKWKKEN
60

HR6999A-263-337-TEV
HOXD9
P28356
SQPQQQQLDPNNPAA
NLTERQVKIWFQNRR
75

HR7031A-153-237-TEV
HP1BP3
Q5SSJ5
ASSPRPKMDAILTEA
GASGSFVVVQKSRKT
84

HR7031B-249-3355-15
HP1BP3
Q5SSJ5
MSAVDPEPQVKLEDV
GASGTFQLKKSGEKP
88

HR7031B-254-330-15
HP1BP3
Q5SSJ5
MEPQVKLEDVLPLAF
QITGKGASGTFQLKK
78

HR7031B-262-330-Av6HT
HP1BP3
Q5SSJ5
VLPLAFTRLCEPKEA
QITGKGASGTFQLKK
69

HR7031C-332-407-15
HP1BP3
Q5SSJ5
MGEKPLLGGSLMEYA
KNGWMEQISGKGFSG
77

HR7031C-332-418-15
HP1BP3
Q5SSJ5
MGEKPLLGGSLMEYA
GFSGTFQLCFPYYPS
88

HR7031C-337-403-15
HP1BP3
Q5SSJ5
MLGGSLMEYAILSAI
QKCEKNGWMEQISGK
68

HR7031C-337-413-15
HP1BP3
Q5SSJ5
MLGGSLMEYAILSAI
QISGKGFSGTFQLCF
78

HR3023-1-506-15
HSF1
Q00613
MDLPVGPGAAGPSNV
FELGEGSYFSEGDGF
506

HR3023-1-506-Av6HT
HSF1
Q00613
DLPVGPGAAGPSNVP
FELGEGSYFSEGDGF
505

HR3023-1-506-TEV
HSF1
Q00613
DLPVGPGAAGPSNVP
FELGEGSYFSEGDGF
505

HR3023A-14
HSF1
Q00613
MDLPVGPGAAGPSNV
PERDDTEFQHPCFLR
106

HR3023A-15
HSF1
Q00613
MDLPVGPGAAGPSNV
PERDDTEFQHPCFLR
106

HR3023C-1-123-15
HSF1
Q00613
MDLPVGPGAAGPSNV
EQLLENIKRKVTSVS
123

HR3023C-10-123-15
HSF1
Q00613
MAGPSNVPAFLTKLW
EQLLENIKRKVTSVS
115

HR3023C-15-118-15
HSF1
Q00613
MVPAFLTKLWTLVSD
FLRGQEQLLENIKRK
105

HR3023C-7-118-15
HSF1
Q00613
MPGAAGPSNVPAFLT
FLRGQEQLLENIKRK
113

HR8180A-12-124-15
HSF4
Q9ULV5
MPGPSPVPAFLGKLW
REQLLERVRRKVPAL
114

HR8180A-12-97-15
HSF4
Q9ULV5
MPGPSPVPAFLGKLW
VVSIEQGGLLRPERD
87

HR8180A-17-119-15
HSF4
Q9ULV5
MVPAFLGKLWALVGD
SFVRGREQLLERVRR
104

HR8180A-17-93-15
HSF4
Q9ULV5
MVPAFLGKLWALVGD
GFRKVVSIEQGGLLR
78

HR8170A-9-94-Av6HT
HSF5
Q4G112
INPNNFPAKLWRLVN
FIRQLNLYGFRKVVL
86

HR7245A-97-218-NHT
HSFX1
Q9UBD0
LPFPQKLWRLVSSNQ
LLVRMKRRVGVKSAP
122

HR3123-1-116-15
ID1
P41134
MKVASGSTATAAAGP
IRDLQLELNSESEVG
116

HR3123-1-121-15
ID1
P41134
MKVASGSTATAAAGP
LELNSESEVGTPGGR
121

HR3123-15
ID1
P41134
MKVASGSTATAAAGP
AEAACVPADDRILCR
155

HR3123-21
ID1
P41134
MKVASGSTATAAAGP
AEAACVPADDRILCR
155

HR3123A-14
ID1
P41134
ALKAGKTASGAGEVV
RDLQLELNSESEVGT
100

HR3123B-14
ID1
P41134
ALKAGKTASGAGEVV
AEAACVPADDRILCR
138

HR3123C-14
ID1
P41134
KTASGAGEVVRCLSE
RDLQLELNSESEVGT
95

HR3123D-14
ID1
P41134
KTASGAGEVVRCLSE
AEAACVPADDRILCR
133

HR3123E-14
ID1
P41134
AGEVVRCLSEQSVAI
RDLQLELNSESEVGT
90

HR3123F-14
ID1
P41134
AGEVVRCLSEQSVAI
AEAACVPADDRILCR
128

HR3123G-54-145-15
ID1
P41134
MPALLDEQQVNVLLY
TLNGEISALTAEAAC
93

HR3123G-59-139-15
ID1
P41134
MEQQVNVLLYDMNGC
VRAPLSTLNGEISAL
82

HR2921-14
ID2
Q02363
MKAFSPVRSVRKNSL
FPSELMSNDSKALCG
134

HR2921-15
ID2
Q02363
MKAFSPVRSVRKNSL
FPSELMSNDSKALCG
134

HR2921-17-85-14
ID2
Q02363
DHSLGISRSKTPVDD
YILDLQIALDSHPTI
69

HR2921-21
ID2
Q02363
MKAFSPVRSVRKNSL
FPSELMSNDSKALCG
134

HR2921-22-134-15
ID2
Q02363
MISRSKTPVDDPMSL
FPSELMSNDSKALCG
114

HR2921-22-85-14
ID2
Q02363
ISRSKTPVDDPMSLL
YILDLQIALDSHPTI
64

HR2921-27-124-15
ID2
Q02363
MTPVDDPMSLLYNMN
ISILSLQASEFPSEL
99

HR2921-27-134-15
ID2
Q02363
MTPVDDPMSLLYNMN
FPSELMSNDSKALCG
109

HR2921-27-85-14
ID2
Q02363
TPVDDPMSLLYNMND
YILDLQIALDSHPTI
59

HR2921-40-134-15
ID2
Q02363
MNDCYSKLKELVPSI
FPSELMSNDSKALCG
96

HR3111-14
ID3
Q712G9
MKALSPVRGCYEAVC
APELVISNDKRSFCH
119

HR3111-15
ID3
Q712G9
MKALSPVRGCYEAVC
APELVISNDKRSFCH
119

HR3111-21
ID3
Q712G9
MKALSPVRGCYEAVC
APELVISNDKRSFCH
119

HR3111A-27-83-15
ID3
Q712G9
MGRGKGPAAEEPLSL
ILQRVIDYILDLQVV
58

HR3111A-32-83-15
ID3
Q712G9
MPAAEEPLSLLDDMN
ILQRVIDYILDLQVV
53

HR4584C-53-112-14
ID4
P47928
DEPALCLQCDMNDCY
IDYILDLQLALETHP
55

HR4626B
IFI16
Q16666
QVTPRRNVLQKRPVI
ISEMHSFIQIKKKTN
202

HR3005-100-519-15
IKZF1
Q13422
MGSSALSGVGGIRLP
FSSHITRGEHRFHMS
421

HR3005-108-519-15
IKZF1
Q13422
MGGIRLPNGKLKCDI
FSSHITRGEHRFHMS
413

HR3005-93-519-15
IKZF1
Q13422
MNGSHRDQGSSALSG
FSSHITRGEHRFHMS
428

HR3005A-IDT-14
IKZF1
Q13422
HARNGLSLKEEHRAY
FSSHITRGEHRFHMS
99

HR3005B-IDT-14
IKZF1
Q13422
EKMNGSHRDQGSSAL
DRLASNVAKRKSSMP
190

HR3064-99-509-15
IKZF3
Q9UKT9
IKLERHVVSFDSSRP
FSSHIARGEHRALLK
411

HR6479A-436-509-NHT
IKZF3
Q9UKT9
RDSVKVINKEGEVMD
FSSHIARGEHRALLK
74

HR7992A-150-221-15
IKZF4
Q9H2S9
MGGIRLPNGKLKCDV
KLHSGEKPFKCPFCN
73

HR7992A-150-232-15
IKZF4
Q9H2S9
MGGIRLPNGKLKCDV
PFCNYACRRRDALTG
84

HR7992A-150-246-15
IKZF4
Q9H2S9
MGGIRLPNGKLKCDV
GHLRTHSVSSPTVGK
98

HR7992A-155-216-15
IKZF4
Q9H2S9
MPNGKLKCDVCGMVC
LLRHIKLHSGEKPFK
63

HR7992A-155-216-15.7-15TEV
IKZF4
Q9H2S9
MPNGKLKCDVCGMVC
LLRHIKLHSGEKPFK
63

HR7992A-155-239-15
IKZF4
Q9H2S9
MPNGKLKCDVCGMVC
RRRDALTGHLRTHSV
86

HR7992B-513-585-15
IKZF4
Q9H2S9
MSKEVLRVVGESGEP
YEFSSHIVRGEHKVG
74

HR7992B-518-585-15
IKZF4
Q9H2S9
MRVVGESGEPVKAFK
YEFSSHIVRGEHKVG
69

HR7992B-523-585-15
IKZF4
Q9H2S9
MSGEPVKAFKCEHCR
YEFSSHIVRGEHKVG
64

HR7992B-528-585-15
IKZF4
Q9H2S9
MKAFKCEHCRILFLD
YEFSSHIVRGEHKVG
59

HR7992C-155-272-Av6HT
IKZF4
Q9H2S9
PNGKLKCDVCGMVCI
KQQSTLEEHKERCHN
118

HR7992C-159-272-Av6HT
IKZF4
Q9H2S9
LKCDVCGMVCIGPNV
KQQSTLEEHKERCHN
114

HR7992C-159-283-Av6HT
IKZF4
Q9H2S9
LKCDVCGMVCIGPNV
RCHNYLQSLSTEAQA
125

HR7992D-197-260-Av6HT
IKZF4
Q9H2S9
TQKGNLLRHIKLHSG
KPYKCNYCGRSYKQQ
64

HR7992D-208-283-Av6HT
IKZF4
Q9H2S9
LHSGEKPFKCPFCNY
RCHNYLQSLSTEAQA
76

HR7992D-210-260-Av6HT
IKZF4
Q9H2S9
SGEKPFKCPFCNYAC
KPYKCNYCGRSYKQQ
51

HR7630A-358-419-NHT
IKZF5
Q9H5V7
QDPQLLHHCQHCDMY
YDFACHFARGQHNQH
62

HR7614A-263-300-15
INSM1
Q01101
MPLGEFICQLCKEEY
KCSRIVRVEYRCPEC
39

HR7614A-263-319-15
INSM1
Q01101
MPLGEFICQLCKEEY
SCPANLASHRRWHKP
58

HR7614B-424-497-15
INSM1
Q01101
MGDGEGAGVLGLSAS
GLTRHINKCHPSENR
75

HR7614B-429-493-15
INSM1
Q01101
MAGVLGLSASAECHL
YSSPGLTRHINKCHP
66

HR7614B-432-497-15
INSM1
Q01101
MLGLSASAECHLCPV
GLTRHINKCHPSENR
67

HR8043A-261-315-Av6HT
INSM2
Q96T92
GEFICQLCKEQYADP
SCPANLASHRRWHKP
55

HR6405A-1-113-TEV
IRF1
P10914
PITRMRMRPWLEMQI
RNKGSSAVRVYRMLP
112

HR7043A-1-113-Av6HT
IRF2
P14316
MPVERMRMRPWLEEQ
IKKGNNAFRVYRMLP
113

HR7043A-1-113-TEV
IRF2
P14316
PVERMRMRPWLEEQI
IKKGNNAFRVYRMLP
112

HR7278A-1-113-TEV
IRF3
Q14653
GTPKPRILPWLVSQL
DPHDPHKIYEFVNSG
112

HR7278B-196-386-TEV
IRF3
Q14653
LVPGEEWEFEVTAFY
LRALVEMARVGGASS
191

HR3173-1-119-14
IRF5
Q13568
MNQSIPVAPTRPRRV
DGPRDMPPQPYKIYE
119

HR3173A-14
IRF5
Q13568
MNQSIPVAPTPPRRV
PPQPYKIYEVCSNGP
125

HR3173A-15
IRF5
Q13568
MNQSIPVAPTPPRRV
PPQPYKIYEVCSNGP
125

HR3173F-8-114-14
IRF5
Q13568
APTPPRRVRLKPWLV
FRLIYDGPRDMPPQP
107

HR3173G-232-477-TEV
IRF5
Q13568
EQLLPDLLISPHMLP
HIWQSQQRLQPVAQA
246

HR7755A-198-455-Av6HT
IRF6
O14896
LEMEVPQAPIQPFYS
RILQTQESWQPMQPT
258

HR5527A-14
IRF7
Q92985
MALAPERAAPRVLFG
RRFVMLRDNSGDPAD
117

HR5527A-15
IRF7
Q92985
MALAPERAAPRVLFG
RRFVMLRDNSGDPAD
117

HR8215A-8-154-TEV
IRF7
Q92985
AAPRVLFGEWLLGEI
EAEAPAAVPPPQGGP
147

HR7337A-9-115-TEV
IRF8
Q02556
RLRQWLIEQIDSSMY
LDISEPYKVYRIVPE
107

HR7302A-205-393-Av6HT
IRF9
Q00978
QRSLEFLLPPEPDYS
LEQTPEQQAAILSLV
189

HR7302A-209-393-Av6HT
IRF9
Q00978
EFLLPPEPDYSLLLT
LEQTPEQQAAILSLV
185

HR7431A-121-188-NHT
IRX1
P78414
GQFQYGDPGRPKNAT
VSTWFANARRRLKKE
68

HR7304A-126-209-NHT
IRX6
P78412
PYERTLGQYQYERYG
TWFANARRRLKKENK
84

HR8326A-180-244-TEV
ISL1
P61371
KTTRVRTVLNEKQLH
QNKRCKDKKRSIMMK
65

HR8291A-190-254-TEV
ISL2
Q96A47
KTTRVRTVLNEKQLH
QNKRCKDKKKSILMK
65

HR8400A-617-732-TEV
JARID2
Q92833
LGRRWGPNVQRLACI
RLEKEVLMEKEILEK
116

HR8400B-804-1099-Av6HT
JARID2
Q92833
KGVLNDFHKCIYKGR
LDELRDTELRQRRQL
296

HR8400B-809-1099-Av6HT
JARID2
Q92833
DFHKCIYKGRSVSLT
LDELRDTELRQRRQL
291

HR8400B-809-1104-Av6HT
JARID2
Q92833
DFHKCIYKGRSVSLT
DTELRQRRQLFEAGL
296

HR8400C-900-1086-Av6HT
JARID2
Q92833
GSILRHLGAVPGVTI
KENGPTLSTISALLD
187

HR8400C-900-1104-Av6HT
JARID2
Q92833
GSILRHLGAVPGVTI
DTELRQRRQLFEAGL
205

HR7951-28-149-Av6HT
IDP2
Q8WYK2
SALTVEELKYADIRN
HRPTCIVRTDSVKTP
122

HR4484C-253-308-Av6HT
JUN
P05412
MIKAERKRMRNRIAA
LASTANMLREQVAQL
57

HR4484C-253-308-TEV
JUN
P05412
IKAERKRMRNRIAAS
LASTANMLREQCAQL
56

HR4765B-273-324-TEV
JUNB
P17275
RKRLRNRLAATKCRK
LSSTAGLLREQVAQL
52

HR4754B-269-324-TEV
JUND
P17535
IKAERKRLRNRIAAS
LASTASLLREQVAQL
56

HR2962A-5-79-Av6HT
KAT5
Q92993
GEIIEGCRLPVLRRN
LKKIQFPKKEAKTPT
75

HR7375A-94-208-TEV
KDM5B
Q9UGL1
EAQTRVKLNFLDQIA
LQKPNLTTDTKDKEY
115

HR7375B-685-750-Av6HT
KDM5B
Q9UGL1
LPDDERQCVKCKTTC
YTLDDLYPMMNALKL
66

HR7375B-696-750-Av6HT
KDM5B
Q9UGL1
KTTCFMSAISCSCKP
YTLDDLYPMMNALKL
55

HR7375C-1487-1544-Av6HT
KDM5B
Q9UGL1
CPAVSCLQPEGDEVD
YICVRCTVKDAPSRK
58

HR7375D-1485-1536-Av6HT
KDM5B
Q9UGL1
AICPAVSCLQPEGDE
PEMAEKEDYICVRCT
52

HR7375E-1123-1227-Av6HT
KDM5B
Q9UGL1
ESLSDLERALTESKE
LRIWLCPHCRRSEKP
105

HR7375E-1123-1241-Av6HT
KDM5B
Q9UGL1
ESLSDLERALTESKE
PPLEKILPLLASLQR
119

HR7375E-1132-1230-Av6HT
KDM5B
Q9UGL1
LTESKETASAMATLG
WLCPHCRRSEKPPLE
99

HR7375E-1134-1241-Av6HT
KDM5B
Q9UGL1
ESKETASAMATLGEA
PPLEKILPLLASLQR
108

HR7375E-1143-1230-Av6HT
KDM5B
Q9UGL1
ATLGEARLREMEALQ
WLCPHCRRSEKPPLE
88

HR7375E-1143-1241-Av6HT
KDM5B
Q9UGL1
ATLGEARLREMEALQ
PPLEKILPLLASLQR
99

HR7188A-306-385-TEV
KDM5D
Q9BY66
HSSAQFIDSYICQVC
EAFGFEQATQEYSLQ
80

HR7714A-77-157-Av6HT
KIAA1683
Q9H0B3
RRVPRLRAVVESQAF
RHILHSSKSLVKKTR
81

HR7682A-10-80-Av6HT
KIAA2018
Q68DE3
PTKKQHRKKNRETHN
ITELKRQNDELLLNG
71

HR8201A-51-160-TEV
KIN
Q60870
QRQLLLASENPQQFM
PETIRRQLELEKKKK
110

HR7553A-272-338-15
KLF1
Q13351
MARKRQAAHTCAHPG
DELTRHYRKHTGQRP
68

HR7553A-292-335-Av6HT
KLF1
Q13351
KSSHLKAHLRTHTGE
ARSDELTRHYRKHTG
44

HR7553B-319-362-Av6HT
KLF1
Q13351
RFARSDELTRHYRKH
FSRSDHLALHMKRHL
44

HR6400A-353-423-TEV
KLF10
Q13118
SAAKVTPQIDSSRIR
REARSDELSRHRRTH
71

HR6390-1-497-15
KLF11
O14901
MHTPDFAGPDDARAV
PGWQAEVGKLNRIAS
497

HR6390-1-501-15
KLF11
O14901
MHTPDFAGPDDARAV
AEVGKLNRIASAESP
501

HR6390-12-512-15
KLF11
O14901
ARAVDIMDICESILE
AESPGSPLVSMPASA
501

HR6390-123-512-15
KLF11
O14901
VSPQVTDSKACTATD
AESPGSPLVSMPASA
390

HR6390-128-512-15
KLF11
O14901
TDSKACTATDVLQSS
AESPGSPLVSMPASA
385

HR6390-15
KLF11
O14901
MHTPDEAGPDDARAV
AESPGSPLVSMPASA
512

HR6390-7-512-15
KLF11
O14901
AGPDDARAVDIMDIC
AESPGSPLVSMPASA
506

HR6390A-379-501-15
KLF11
O14901
SQNCVPQVDFSRRRN
AEVGKLNRIASAESP
123

HR6390A-384-497-15
KLF11
O14901
PQVDFSRRRNYVCSF
PGWQAEVGKLNRIAS
114

HR6390B-397-462-15
KLF11
O14901
SFPGCRKTYFKSSHL
HTGEKKFVCPVCDRR
66

HR6390B-402-457-15
KLF11
O14901
RKTYFKSSHLKAHLR
RHRRTHTGEKKFVCP
56

HR7238A-306-400-TEV
KLF12
Q9Y4X4
SESPDSRKRRIHRCD
FSRSDHLALHRRRHM
95

HR8436A-125-193-Av6HT
KLF16
Q9BXK1
KSHRCPFPDCAKAYY
RTHTGEKRFSCPLCS
69

HR7123A-272-355-TEV
KLF2
Q9Y5W3
HTCSYAGCGKTYTKS
FSRSDHLALHMKRHM
84

HR7880A-251-343-TEV
KLF3
P57682
PDTQRKRRIHRCDYD
FSRSDHLALHRKRHM
93

HR4433-1-347-14
KLF5
Q13887
MATRVLSMSARLGPV
ASKLAIHNPNLPTTL
347

HR4433-9-342-14
KLF5
Q13887
MSARLGPVPQPPAPQ
YAATIASKLAIHNPN
335

HR4668C-168-283-21
KLF6
Q99612
MELPSPGKVRSGTSG
FSRSDHLALHMKRHL
117

HR4668C-173-283-21
KLF6
Q99612
MGKVRSGTSGKPGDK
FSRSDHLALHMKRHL
112

HR4668C-173-283-Av6HT
KLF6
Q99612
GKVRSGTSGKPGDKG
FSRSDHLALHMKRHL
111

HR4668C-173-283-TEV
KLF6
Q99612
GKVRSGTSGKPGDKG
FSRSDHLALHMKRHL
111

HR4668C-191-283-21
KLF6
Q99612
MASPDGRRRVHRCHF
FSRSDHLALHMKRHL
94

HR4668C-196-283-21
KLF6
Q99612
MRRRVHRCHFNGCRK
FSRSDHLALHMKRHL
89

HR4668D-205-283-21
KLF6
Q99612
MNGCRKVYTKSSHLK
FSRSDHLALHMKRHL
80

HR4668D-210-283-21
KLF6
Q99612
MVYTKSSHLKAHQRT
FSRSDHLALHMKRHL
75

HR8165A-231-302-Av6HT
KLF7
O75840
TKSSHLKAHQRTHTG
FSRSDHLALHMKRHL
72

HR8376A-270-332-Av6HT
KLF8
O95600
RRRIHQCDFAGCSKV
SDELTRHFRKHTGIK
63

HR7597A-181-244-NHT
KLF9
Q13886
LKKFSRSDELTRHYR
PSMIKRSKKALANAL
64

HR6918A-877-937-TEV
KNL2
Q6P0N0
DKEWNEKELQKLHCA
MENPRGKGSQKHVTK
61

HR6489A-15
L3MBTL3
Q96JM7
RRKRRGDSAVLKQGL
QPPLSPLELMEASEH
346

HR6489A-Av6HT
L3MBTL3
Q96JM7
RRKRRGDSAVLKQGL
QPPLSPLELMEASEH
346

HR6489A-TEV
L3MBTL3
Q96JM7
RRKRRGDSAVLKQGL
QPPLSPLELMEASEH
346

HR6490A-15
L3MBTL4
Q8NA19
MKQPNRKRKLNMDSK
SAFGCPYSDMNLKKE
414

HR6490A-30-371-15
L3MBTL4
Q8NA19
MEKKPKDSTTPLSHV
TGHPLEVPQRTNDLK
343

HR6490A-30-371-Av6HT
L3MBTL4
Q8NA19
EKKPKDSTTPLSHVP
TGHPLEVPQRTNDLK
342

HR6490A-30-371-Na6HT
L3MBTL4
Q8NA19
EKKPKDSTTPLSHVP
TGHPLEVPQRTNDLK
342

HR6490A-30-371-TEV
L3MBTL4
Q8NA19
EKKPKDSTTPLSHVP
TGHPLEVPQRTNDLK
342

HR6490A-Av6HT
L3MBTL4
Q8NA19
KQPNRKRKLNMDSKE
SAFGCPYSDMNLKKE
413

HR6490A-TEV
L3MBTL4
Q8NA19
KQPNRKRKLNMDSKE
SAFGCPYSDMNLKKE
413

HR2473-14
LARP1
Q6PKG0
MNTLFRFWSFFLRDH
AKWTSQHSNTQTLGK
185

HR7995A-377-483-Av6HT
LARP1
Q6PKG0
ISLIFAALKDSKVVE
SASLPDLDSENWIEV
107

HR6994A-210-292-NHT
LARP1B
Q659C4
VEEALLKEYIKRQIE
EVEIVDEKMRKKIEP
83

HR7969A-107-200-TEV
LARP4
Q71RC2
SGESNSAVSTEDLKE
DEKGEKVRPSHKRCI
94

HR6949A-152-237-NHT
LARP4B
Q92615
SQEDPREVLKKTLEF
DEKGEKVRPNQNRCI
86

HR7099A-69-134-NHT
LASS2
Q96G23
NIKEKTRLRAPPNAT
RRRNQDRPSLLKKFR
66

HR8001A-86-135-TEV
LASS5
Q8N5B7
AQPNAILEKVFISIT
KIQCWFRHRRNQDKP
50

HR6906A-77-127-TEV
LASS6
Q6ZMG9
APPNAILEKVFTAIT
IQRWFRQRRNQEKPS
51

HR6954A-124-198-NHT
LBX1
P52954
KRRKSRTAFTNHQIY
LEEMKADVESAKKLG
75

HR8118A-343-405-TEV
LCOR
Q96JN0
RGRYRQYNSEILEEA
GTLKNPPKKKMKLMR
63

HR7552A-519-579-TEV
LCORL
Q8N3X6
RGRYRQYDHEIMEEA
RSGTLKTPPKKKLRL
61

HR7767A-314-501-Av6HT
LENG9
Q96B70
APCQPRPTHFVALMV
RTGGPFQPLAEIRLE
188

HR8129A-23-126-Av6HT
LHX1
P48742
AWHVKCVQCCECKCN
FVCKEDYLSNSSVAK
104

HR7637A-262-334-TEV
LHX2
P50458
SSQKTKRMRTSFKHH
KFRRNLLRQENTGVD
73

HR7663A-23-150-TEV
LHX3
Q9UBR4
LARRADLRREIPLCA
FYLMEDSRLVCKADY
128

HR7789A-16-91-NHT
LHX4
Q969G2
LPEMLGVPMQQIPQC
CKEDFFKRFGTKCTA
76

HR7587A-24-119-NHT
LHX5
Q9H2C1
AWHIKCVQCCECKTN
LYVIDENKFVCKDDY
96

HR7172-1-267-TEV
LHX9
Q9NQ69
LNGTTLEAAMLFHGI
PPSQKTKRMRTSFKH
266

HR7172-1-270-15
LHX9
Q9NQ69
MLNGTTLEAAMLFHG
QKTKRMRTSFKHHQL
270

HR7525A-134-187-Av6HT
LIN28A
Q9H9Z2
MSKGDRCYNCGGLDH
SCPLKAQQGPSAQGK
55

HR7525A-134-187-TEV
LIN28A
Q9H9Z2
SKGDRCYNCGGLDHH
SCPLKAQQGPSAQGK
54

HR7198A-25-103-NHT
LIN28B
Q6ZN17
SQVLRGTGHCKWFNV
KSSKGLESIRVTGPG
79

HR7658-1-237-Av6HT
LMX1A
Q8TE12
LDGLKMEENFQSAID
KVRETLAAETGLSVR
236

HR7658-1-247-Av6HT
LMX1A
Q8TE12
LDGLKMEENFQSAID
GLSVRVVQVWFQNQR
246

HR7658-1-257-Av6HT
LMX1A
Q8TE12
LDGLKMEENFQSAID
FQNQRAKMKKLARRQ
256

HR7658-13-303-Av6HT
LMX1A
Q8TE12
SAIDTSASFSSLLGR
PYTALPTPQQLLAIE
291

HR7658A-61-153-NHT
LMX1A
Q8TE12
QCASCKEPLETTCFY
EGQLLCKGDYEKERE
93

HR7658B-13-153-Av6HT
LMX1A
Q8TE12
SAIDTSASFSSLLGR
EGQLLCKGDYEKERE
141

HR7658B-32-153-Av6HT
LMX1A
Q8TE12
KSVCEGCQRVILDRF
EGQLLCKGDYEKERE
122

HR6403A-128-207-15
LYL1
P12980
RLKRRPSHCELDLAE
RLAMKYIGFLVRLLR
80

HR6403A-133-207-15
LYL1
P12980
PSHCELDLAEGHQPQ
RLAMKYIGFLVRLLR
75

HR6403A-146-207-15
LYL1
P12980
PQKVARRVFTNSRER
RLAMKYIGFLVRLLR
62

HR6403A-146-226-15
LYL1
P12980
PQKVARRVFTNSRER
ALAAGPTPPGPRKRP
81

HR7569A-1-80-TEV
MAEL
Q96JY0
PNRKASRNAYYFFVQ
GKDPGPSEKQKPVFT
79

HR4779B-255-300-14
MAF
O75444
MLHFDDRFSDEQLVT
VIRLKQKRRTLKNRG
47

HR7214A-221-319-Av6HT
MAFA
Q8NHW3
VRLEERFSDDQLVSM
KERDLYKEKYEKLAG
99

HR7214A-225-319-Av6HT
MAFA
Q8NHW3
ERFSDDQLVSMSVRE
KERDLYKEKYEKLAG
95

HR7214A-228-313-Av6HT
MAFA
Q8NHW3
SDDQLVSMSVRELNR
EVGRLAKERDLYKEK
86

HR7214A-236-319-Av6HT
MAFA
Q8NHW3
SVRELNRQLRGFSKE
KERDLYKEKYEKLAG
84

HR7214A-246-319-Av6HT
MAFA
Q8NHW3
GFSKEEVIRLKQKRR
KERDLYKEKYEKLAG
74

HR6931A-209-305-Av6HT
MAFB
Q9Y5Q3
DRFSDDQLVSMSVRE
RDAYKVKCEKLANSG
97

HR6931B-210-236-Av6HT
MAFB
Q9Y5Q3
RFSDDQLVSMSVREL
RELNRHLRGFTKDEV
27

HR6931B-210-251-Av6HT
MAFB
Q9Y5Q3
RFSDDQLVSMSVREL
IRLKQKRRTLKNRGY
42

HR8265A-31-74-Av6HT
MAFF
Q9ULX9
GLSVRELNRHLRGLS
KNRGYAASCRVKRVC
44

HR7795A-21-123-TEV
MAFG
Q15525
GTSLTDEELVTMSVR
SKYEALQTFARTVAR
103

HR7958A-24-123-TEV
MAFK
O60675
LSDDELVSMSVRELN
SKYEALQTFARTVAR
100

HR8183A-390-479-Av6HT
MATR3
P43243
MQKGRVETSRVVHIM
PVRVHLSQKYKRIKK
91

HR8183A-390-479-TEV
MATR3
P43243
QKGRVETSRVVHIMD
PVRVHLSQKYKRIKK
90

HR8110A-22-107-TEV
MAX
P61244
ADKRAHHNALERKRR
ALLEQQVRALEKARS
86

HR8332A-230-361-NHT
MAZ
P56270
ACEMCGKAFRDVYHL
SRPDHLNSHVRQVHS
82

HR8332A-280-361-TEV
MAZ
P56270
ACEMCGKAFRDVYHL
SRPDHLNSHVRQVHS
82

HR8039A-131-243-TEV
MBD1
Q9UIS9
GCCENCGISFSGDGT
RGCQTQEDCGHCPIC
113

HR8039A-131-262-TEV
MBD1
Q9UIS9
GCCENCGISFSGDGT
RPGLRRQWKCVQRRC
132

HR5530A-14
MBD2
Q9UBB5
MEPVPFPSGSAGPGP
NDPLNQNKGKPDLNT
118

HR5530A-15
MBD2
Q9UBB5
MEPVPFPSGSAGPGP
NDPLNQNKGKPDLNT
118

HR6416-1-220-15
MBD3
O95983
MERKRWECPALPQGW
VWLNTTQPLCKAFMV
220

HR6416-1-226-15
MBD3
O95983
MERKRWECPALPQGW
QPLCKAFMVTDEDIR
226

HR6416-1-261-15
MBD3
O95983
MERKRWECPALPQGW
MLAHVEELARDGEAP
261

HR6416-15
MBD3
O95983
MERKRWECPALPQGW
EEEEEPDPDPEMEHV
291

HR6416-33-291-15
MBD3
O95983
VFYYSPSGKKFRSKP
EEEEEPDPDPEMEHV
259

HR6416-55-291-15
MBD3
O95983
MGSMDLSTFDFRTGK
EEEEEPDPDPEMEHV
238

HR6416A-1-106-15
MBD3
O95983
MERKRWECPALPQGW
KPDLNTALPVRQTAS
106

HR6416A-1-111-15
MBD3
O95983
MERKRWECPALPQGW
TALPVRQTASIFKQP
111

HR6416A-1-117-15
MBD3
O95983
MERKRWECPALPQGW
QTASIFKQPVTKITN
117

HR6416B-1-72-15
MBD3
O95983
MERKRWECPALPQGW
DLSTFDFRTGKMLMS
72

HR6416B-1-77-15
MBD3
O95983
MERKRWECPALPQGW
DFRTGKMLMSKMNKS
77

HR4635B-14
MBD4
O95243
MTECRKSVPCGWERV
VLSKRGIKSRYKDCS
81

HR4635B-15
MBD4
O95243
MTECRKSVPCGWERV
VLSKRGIKSRYKDCS
81

HR4635C-14
MBD4
O95243
RSSECNHLLQEPIAS
FTVLSKRGIKSRYKD
101

HR4635D-55-161-14
MBD4
O95243
MIKRSSECNPLLQEP
SKRGIKSRYKDCSMA
108

HR4635D-55-161-Av6HT
MBD4
O95243
IKRSSECNPLLQEPI
SKRGIKSRYKDCSMA
107

HR4635D-55-161-TEV
MBD4
O95243
IKRSSECNPLLQEPI
SKRGIKSRYKDCSMA
107

HR4635D-55-191-14
MBD4
O95243
MIKRSSECNPLLQEP
NLRTRSKCKKDVFMP
138

HR4635D-61-156-14
MBD4
O95243
MCNPLLQEPIASAQF
DFTVLSKRGIKSRYK
97

HR4635D-61-186-14
MBD4
O95243
MCNPLLQEPIASAQF
NNSNWNLRTRSKCKK
127

HR4635E-437-574-TEV
MBD4
O95243
KWTPPRSPFNLVQET
DHKLNKYHDWLWENH
138

HR8088A-178-246-TEV
MBNL1
Q9NR56
RTDRLEVCREYQRGN
EKCKYFHPPAHLQAK
69

HR7551A-175-243-TEV
MBNL2
Q5VZF2
RTDKLEVCREFQRGN
EKCKYFHPPAHLQAK
69

HR7762A-173-241-TEV
MBNL3
Q9NUK0
RCSREKCKYFHPPAH
NGATPVFNPTVFHCQ
69

HR3168-14
MDS1
Q13465
MRSKGRARKLATNNE
QADVYMPGLQCAFLS
169

HR7632A-77-171-TEV
MECP2
P51608
SEGSGSAPAVPEASA
VGDTSLDPNDFDFTV
95

HR4583C-2-78-TEV
MEF2A
Q02078
GRKKIQITRIMDERN
KVLLKYTEYNEPHES
77

HR8120A-2-94-TEV
MEF2B
Q02080
GRKKIQISRILDQRN
TNTDILETLKRRGIG
93

HR4550C-2-78-TEV
MEF2D
Q14814
GRKKIQIQRITDERN
KVLLKYTEYNEPHES
77

HR8225A-277-341-NHT
MEIS1
O00470
GIFPKVATNIMRAWL
RRRIVQPMIDQSNRA
65

HR8225A-277-341-TEV
MEIS1
O00470
GIFPKVATNIMRAWL
RRRIVQPMIDQSNRA
65

HR8514A-250-313-TEV
MEIS3P2
A8K058
GIFPKVATNIMRAWL
ARRRMVQPMIDQSNR
64

HR7119A-175-247-NHT
MEOX2
P50222
QEGNYKSEVNSKPRK
VWFQNRRMKWKRVKG
73

HR7798B-1047-1351-Av6HT
MET
P08581
LQNTVHIDLSALNPE
ISAIFSTFIGEHYVH
305

HR8521A-1-179-TEV
MGMT
P16455
DKDCEMKRTTLDSPL
KEWLLAHEGHRLGKP
178

HR7181A-199-243-TEV
MIER1
Q8N108
YKENEKVYENDDQLL
KDASRRTGDEKGVEA
45

HR7181A-199-265-TEV
MIER1
Q8N108
YKENEKVYENDDQLL
KDNEQALYELVKCNF
67

HR7181A-203-243-TEV
MIER1
Q8N108
EKVYENDDQLLWDPE
KDASRRTGDEKGVEA
41

HR7181A-203-265-TEV
MIER1
Q8N108
EKVYENDDQLLWDPE
KDNEQALYELVKCNF
63

HR7181A-208-260-TEV
MIER1
Q8N108
NDDQLLWDPEYLPED
EGSHIKDNEQALYEL
53

HR3622D-1-299-14
MINK1
Q8N4C8
MGDPAPARSLDDIDL
KFPFIRDQPTERQVR
299

HR3622D-13-294-14
MINK1
Q8N4C8
MIDLSALRDPAGIFE
TEQLLKFPFIRDQPT
283

HR3622D-8-299-14
MINK1
Q8N4C8
MRSLDDIDLSALRDP
KFPFIRDQPTERQVR
293

HR3622D-9-294-14
MINK1
Q8N4C8
MSLDDIDLSALRDPA
TEQLLKFPFIRDQPT
287

HR3622E-1180-1284-14
MINK1
Q8N4C8
MIYGSSAGFHAVDVD
GEKAIEIRSVETGHL
106

HR3622E-1185-1282-14
MINK1
Q8N4C8
MAGFHAVDVDSGNSY
GWGEKAIEIRSVETG
99

HR7746A-86-152-Av6HT
MIXL1
Q9H2W2
QRRKRTSFSAEQLQL
RAKSRRQSGKSFQPL
67

HR7244A-248-367-NHT
MKRN1
Q9UHC7
DAAQRSQHIKSCIEA
EKQKLILKYKEAMSN
120

HR7430A-278-369-NHT
MKRN3
Q13064
DAAQREEHMRACIEA
NRIVKSCPQCRVTSE
92

HR7905A-54-146-Av6HT
MKX
Q8IYA7
NLGLRHRRTGARQNG
VRQPDLSWALRIKLY
93

HR4516M-1422-1490-15
MLL
Q03164
MILTSVPITPRVVCF
CRRCKFCHVCGRQHQ
70

HR4516M-1422-1514-15
MLL
Q03164
MILTSVPITPRVVCF
KCRNSYHPECLGPNY
94

HR4516M-1427-1486-15
MLL
Q03164
MPITPRVVCFLCASS
ENWCCRRCKFCHVCG
61

HR4516M-1427-1514-15
MLL
Q03164
MPITPRVVCFLCASS
KCRNSYHPECLGPNY
89

HR4516N-1476-1537-15
MLL
Q03164
MCRRCKFCHVCGRQH
KVWICTKCVRCKSCG
63

HR4516O-2012-2081-15
MLL
Q03164
MNGLEPENIHMMIGS
YTCKIVECRPPVVEP
71

HR4516O-2017-2076-15
MLL
Q03164
MENIHMMIGSMTIDC
RKRCVYTCKIVECRP
61

HR4516O-2017-2082-15
MLL
Q03164
MENIHMMIGSMTIDC
TCKIVECRPPVVEPD
67

HR8195A-1-143-Av6HT
MLLT1
Q03111
DNQCTVQVRLELGHR
TEFRYKLLRAGGVMV
142

HR7909A-1-139-Av6HT
MLLT3
P42568
ASSCAVQVKLELGHR
NNPTEDFRRKLLKAG
138

HR7716A-121-220-NHT
MLX
Q9UH92
AYKESYKDRRRRAHT
TALKIMKVNYEQIVK
100

HR7887A-717-802-Av6HT
MLXIP
Q9HAP2
LKNRQMKHISAEQKR
EELNATIISCQQLLP
86

HR7887A-726-802-Av6HT
MLXIP
Q9HAP2
SAEQKRRFNIKMCFD
EELNATIISCQQLLP
77

HR7434A-647-736-NHT
MLXIPL
Q9NP71
TENRRITHISAEQKR
EELNAAINLCQQQLP
90

HR7223A-347-541-Av6HT
MRF
Q9Y2G1
NYQSIKWQPHQQNKW
IIVRASNPGQFESDS
195

HR7242A-112-186-TEV
MRRF
Q96E11
ESGMNLNPEVEGTLI
DTVSEDTIRLIEKQI
75

HR4485B-103-183-14
MSC
O60682
MECKQSQRNAANARE
ENGYVHPVNLTWPFV
82

HR4485B-103-188-14
MSC
O60682
MECKQSQRNAANARE
HPVNLTWPFVVSGRP
87

HR4485B-103-188-Av6HT
MSC
O60682
ECKQSQRNAANARER
HPVNLTWPFVVSGRP
86

HR4485B-103-188-TEV
MSC
O60682
ECKQSQRNAANARER
HPVNLTWPFVVSGRP
86

HR4485B-103-194-14
MSC
O60682
MECKQSQRNAANARE
WPFVVSGRPDSDTKE
93

HR4485B-103-199-14
MSC
O60682
MECKQSQRNAANARE
SGRPDSDTKEVSAAN
98

HR4485B-135-194-14
MSC
O60682
MPWVPPDTKLSKLDT
WPFVVSGRPDSDTKE
61

HR4485C-103-174-14
MSC
O60682
MECKQSQRNAANARE
RQLLQEDRYENGYVH
73

HR7186A-122-193-NHT
MSGN1
A6NI15
SVQRRRKASEREKLR
TDLLNRGREPRAQSA
72

HR7207A-25-769-TEV
MST1R
Q04912
EDWQCPRTPYAASRD
GAQVPGSWTFQYRED
745

HR4585B-167-224-TEV
MSX1
P28360
RKPRTPFTTAQLLAL
VKIWFQNRRAKAKRL
58

HR7691A-143-200-TEV
MSX2
P35548
RKPRTPFTTSQLLAL
VKIWFQNRRAKAKRL
58

HR4538-1-540-14
MTA1
Q13330
MAANMYRVGDYVYFE
LKQAVRKPLEAVLRY
540

HR4538-1-540-15
MTA1
Q13330
MAANMYRVGDYVYFE
LKQAVRKPLEAVLRY
540

HR4538-1-545-14
MTA1
Q13330
MAANMYRVGDYVYFE
RKPLEAVLRYLETHP
545

HR4538-1-545-15
MTA1
Q13330
MAANMYRVGDYVYFE
RKPLEAVLRYLETHP
545

HR4538C-375-438-14
MTA1
Q13330
MGVVNGTGAPGQSPG
WKKYGGLKMPTRLDG
65

HR4538C-380-433-14
MTA1
Q13330
MTGAPGQSPGAGRAC
SCWTYWKKYGGLKMP
55

HR4538D-15
MTA1
Q13330
ALVPQGGPVLCRDEM
QVYIPNYNKPNPNQI
97

HR4538D-Av6HT
MTA1
Q13330
ALVPQGGPVLCRDEM
QVYIPNYNKPNPNQI
97

HR4538D-TEV
MTA1
Q13330
ALVPQGGPVLCRDEM
QVYIPNYNKPNPNQI
97

HR4621B-352-412-15
MTA2
O94776
MSKPGMNGAGFQKGL
WKKYGGLKTPTQLEG
62

HR4621B-357-407-15
MTA2
O94776
MNGAGFQKGLTCESC
SCWIYWKKYGGLKTP
52

HR4621C-1-140-15
MTA2
O94776
MAANMYRVGDYVYFE
CFFYSLVFDPVQKTL
140

HR4621C-1-145-15
MTA2
O94776
MAANMYRVGDYVYFE
LVFDPVQKTLLADQG
145

HR4621C-1-161-15
MTA2
O94776
MAANMYRVGDYVYFE
IRVGCKYQAEIPDRL
161

HR4621C-1-166-15
MTA2
O94776
MAANMYRVGDYVYFE
KYQAEIPDRLVEGES
166

HR4468C-268-324-TEV
MTA3
Q9BIC8
AISALVPQGGPVLCR
IQQDFLPWKSLTSII
57

HR6907A-148-207-NHT
MTF1
Q14872
PRTYSTAGNLRTHQK
VHTKEKPFECDVQGC
60

HR6878A-57-136-TEV
MXD1
Q05195
SRSTHNEMEKNRRAH
LQREQRHLKRQLEKL
80

HR6454A-24-140-14
MXD4
Q14582
EHGYASVLPFDGDFA
LKRRLEQLSVQSVER
117

HR6454A-44-143-14
MXD4
Q14582
AAGLVRKAPNNRSSH
RLEQLSVQSVERVRT
100

HR6454A-44-143-15
MXD4
Q14582
AAGLVRKAPNNRSSH
RLEQLSVQSVERVRT
100

HR6454A-49-140-14
MXD4
Q14582
RKAPNNRSSHNELEK
LKRRLEQLSVQSVER
92

HR6454A-56-136-14
MXD4
Q14582
SSHNELEKHRRAKLR
EHRFLKRRLEQLSVQ
81

HR6454A-56-136-15
MXD4
Q14582
SSHNELEKHRRAKLR
EHRFLKRRLEQLSVQ
81

HR6436A-58-155-14
MXI1
P50539
SSGSSNTSTANRSTH
KWRLEQLQGPQEMER
98

HR6436A-63-149-14
MXI1
P50539
NTSTANRSTHNELEK
REQRFLKWRLEQLQG
87

HR6436A-63-155-14
MXI1
P50539
NTSTANRSTHNELEK
KWRLEQLQGPQEMER
93

HR6436A-68-149-14
MXI1
P50539
NRSTHNELEKNRRAH
REQRRLKWRLEQLQG
82

HR8112A-85-136-TEV
MYBL1
P10243
LIKGPWTKEEDQRVI
GKQCRERWHNHLNPE
52

HR3593B-28-78-TEV
MYBL2
P10244
SKCKVKWTHEEDEQL
RTDQQCQYRWLRVLN
51

HR4620B-353-438-TEV
MYC
P01106
NVKRRTHNVLERQRR
REQLKHKLEQLRNSC
86

HR7184A-279-364-NHT
MYCL1
P12524
DVTKRKNHNFLERKR
RQQQLQKRIAYLIGY
86

HR8502A-1-111-Av6HT
MYCL2
P12525
DRDSYHHYFYDYDGG
EPLERAVSDLLAVGA
110

HR6419A-367-464-14
MYCN
P04198
AKSLSPRNSDSEDSE
RQQQLLKKIEHARTC
98

HR7983A-4-117-TEV
MYNN
Q9NPC7
SHHCEHLLERLNKQR
KVEEVVTKCKIKMED
114

HR4693-66-224-14
MYOG
P15173
MLPWACKVCKRKSVS
VEDVSVAFPDETMPN
160

HR4693B-71-145-14
MYOG
P15173
MKVCKRKSVSVDRRR
RLQALLSSLNQEERD
76

HR4693B-73-156-14
MYOG
P15173
MCKRKSVSVDRRRAA
EERDLRYRGGGGPQP
85

HR4693B-76-138-14
MYOG
P15173
MKSVSVDRRRAATLR
SAIQYIERLQALLSS
64

HR4693B-78-156-14
MYOG
P15173
MVSVDRRRAATLREK
EERDLRYRGGGGPQP
80

HR7507A-115-181-TEV
MYSM1
Q5VVJ2
ASYSVKWTIEEKELF
VKCGLDKETPNQKTG
67

HR7507B-367-470-TEV
MYSM1
Q5VVJ2
HEEEELKPPEQEIEI
IGAINFGGEQAVYNR
104

HR4437B-298-605-NHT
MYST2
O95251
LENLTSEYDLDLFRR
RSNSNKTMDPSCLKW
308

HR8033A-559-650-TEV
MYT1
Q01538
SYRPNVAPATPRANL
LSTRCWEMPENLSTK
92

HR6948A-486-549-TEV
MYT1L
Q9UL68
HVKKPYYDPSRTEKK
PPEILAMHESVLKCP
64

HR7215A-37-128-TEV
MZF1
P28698
DPGPEAARLRFRCFR
EAAALVDGLRREPGG
92

HR6963A-75-157-TEV
NANOG
Q9H9S0
KQPTSAEKSVAKKED
FQNQRMKSKRWQKNN
83

HR7935-106-160-Av6HT
NANOGNB
Q7Z5D8
KRLVSKSLMHTLWAK
ISQWFCKTRKKYNKE
55

HR8537A-41-101-Av6HT
NANOGP1
Q8N7R0
TRTVFSSTQLCVLND
QNQRMKSKRWQKNNW
61

HR3639F-24-96-15
NCOA1
Q15788
MCDTLASSTEKRRRE
RMEQEKSTTDDDVQK
74

HR3639F-29-91-15
NCOA1
Q15788
MSSTEKRRREQENKY
IQLMKRMEQEKSTTD
64

HR3639G-104-174-15
NCOA1
Q15788
MQGVIEKESLGPLLL
LHVGDHAEFVKNLLP
72

HR3639G-107-179-15
NCOA1
Q15788
MIEKESLGPLLLEAL
HAEFVKNLLPKSLVN
74

HR3639G-112-174-15
NCOA1
Q15788
MLGPLLLEALDGFFF
LHVGDHAEFVKNLLP
64

HR3639G-112-203-15
NCOA1
Q15788
MLGPLLLEALDGFFF
RRNSHTFNCRMLIHP
93

HR3639G-99-179-15
NCOA1
Q15788
MISSSSQGVIEKESL
HAEFVKNLLPKSLVN
82

HR3639H-1185-1441-15
NCOA1
Q15788
MSPFSQLAANPEASL
PQAQQKSLLQQLLTE
258

HR3639H-1190-1441-15
NCOA1
Q15788
MLAANPEASLANRNS
PQAQQKSLLQQLLTE
253

HR3639H-1205-1441-15
NCOA1
Q15788
MVSRGMTGNIGGQFG
PQAQQKSLLQQLLTE
238

HR3639H-1210-1441-15
NCOA1
Q15788
MTGNIGGQFGTGINP
PQAQQKSLLQQLLTE
233

HR3639H-1216-1441-15
NCOA1
Q15788
MQFGTGINPQMQQNV
PQAQQKSLLQQLLTE
227

HR4453I-100-258-Av6HT
NCOA3
Q9Y6Q9
MVSSTGQGVIDKDSL
SCMICVARRITTGER
160

HR4453I-100-258-NHT
NCOA3
Q9Y6Q9
VSSTGQGVIDKDSLG
SCMICVARRITTGER
159

HR7885A-433-486-TEV
NCOR1
O75376
DRQFMNVWTDHEKEI
PDCVLYYYLTKKNEN
54

HR4636E-602-671-14
NCOR2
Q9Y618
MAELASMELNESSRW
KKRQNLDEILQQHKL
71

HR4636E-608-670-14
NCOR2
Q9Y618
MELNESSRWTEEEME
YKKRQNLDEILQQHK
64

HR7360A-102-160-TEV
NEUROD1
Q13562
RRMKANARERNRMHG
AKNYIWALSEILRSG
59

HR7134A-122-180-TEV
NEUROD2
Q15784
RRQKANARERNRMHD
AKNYIWALSEILRSG
59

HR7078A-87-146-TEV
NEUROD4
Q9HD90
ARRVKANARERTRMH
ARNYIWALSEVLETG
60

HR8276A-95-153-NHT
NEUROD6
Q96NK8
RRQEANARERNRMHG
AKNYIWALSEILRIG
59

HR8276A-95-153-TEV
NEUROD6
Q96NK8
RRQEANARERNRMHG
AKNYIWALSEILRIG
59

HR6971A-104-175-NHT
NEUROG2
Q9H2A3
ETVQRIKKTRRLKAN
IWALTETLRLADHCG
72

HR7673A-76-167-NHT
NEUROG3
Q9Y4Z2
ALSKQRRSRRKKAND
APHCGELGSPGGSPG
92

HR7259A-264-544-TEV
NFAT5
O94916
KKSPMLCGQYPVKSE
AGRSHDVQPFTYTPD
281

HR8282A-416-591-Av6HT
NFATC1
O95644
MDWQLPSHSGPYELR
SLQVASNPIECSQRS
177

HR8282A-416-591-TEV
NFATC1
O95644
DWQLPSHSGPYELRI
SLQVASNPIECSQRS
176

HR7889A-421-595-TEV
NFATC3
Q12968
DWPLPAHFGQCELKI
SLQIASIPVECSQRS
175

HR4653B-214-293-14
NFE2
Q16621
MAKPTARGEAGSRDE
AAQNCRKRKLETIVQ
81

HR4653B-218-293-14
NFE2
Q16621
MARGEAGSRDERRAL
AAQNCRKRKLETIVQ
77

HR4653B-223-293-14
NFE2
Q16621
MGSRDERRALAMKIP
AAQNCRKRKLETIVQ
72

HR4653B-234-293-14
NFE2
Q16621
MKIPFPTDKIVNLPV
AAQNCRKRKLETIVQ
61

HR4653C-259-338-14
NFE2
Q16621
MLTESQLALVRDIRR
QQLTELYRDIFQHLR
81

HR4653C-274-338-14
NFE2
Q16621
MGKNKVAAQNCRKRK
QQLTELYRDIFQHLR
66

HR7672A-605-674-NHT
NFE2L1
Q14494
DFLDKQMSRDEHRAR
RRGKNKMAAQNCRKR
70

HR3520B-21
NFE2L2
Q16236
MMDLELPPPGLPSQQ
TSGSANYSQVAHIPK
110

HR3520F-21
NFE2L2
Q16236
DMDLIDILWRQDIDL
TSGSANYSQVAHIPK
95

HR3520L-455-594-14
NFE2L2
Q16236
TRDELRAKALHIPFP
EYSLQQTRDGNVFLV
140

HR3520L-455-599-14
NFE2L2
Q16236
TRDELRAKALHIPFP
QTRDGNVFLVPKSKK
145

HR3520M-435-523-15
NFE2L2
Q16236
MGHRKTPFTKDKHSS
VAAQNCRKRKLENIV
90

HR3520M-440-523-15
NFE2L2
Q16236
MPFTKDKHSSRLEAH
VAAQNCRKRKLENIV
85

HR3520N-489-570-15
NFE2L2
Q16236
MQFNEAQLALIRDIR
QLSTLYLEVFSMLRD
83

HR3520O-445-523-15
NFE2L2
Q16236
MKHSSRLEAHLTRDE
VAAQNCRKRKLENIV
80

HR7720A-530-598-NHT
NFE2L3
Q9Y4A8
DTDRNLSRDEQRAKA
RRGKNKVAAQNCRKR
69

HR7383A-63-165-TEV
NFIA
Q12857
EKPEVKQKWASRLLA
VKSPQCSNPGLCVQP
103

HR7383A-63-184-TEV
NFIA
Q12857
EKPEVKQKWASRLLA
VSVKELDLYLAYFVH
122

HR7383A-7-165-TEV
NFIA
Q12857
LTQDEFHPFIEALLP
VKSPQCSNPGLCVQP
159

HR7279A-8-166-Av6HT
NFIB
O00712
LTQDEFHPFIEALLP
MKSPHCTNPALCVQP
159

HR7320A-61-170-TEV
NFIC
P08651
LLGEKPEVKQKWASR
QCGHPVLCVQPHHIG
110

HR7320A-61-186-TEV
NFIC
P08651
LLGEKPEVKQKWASR
AVKELDLYLAYFVRE
126

HR7320A-64-166-TEV
NFIC
P08651
EKPEVKQKWASRLLA
VKAAQCGHPVLCVQP
103

HR7320A-8-166-TEV
NFIC
P08651
LTQDEFHPFIEALLP
VKAAQCGHPVLCVQP
159

HR3633C-804-893-TEV
NFKB1
P19838
AQGDMKQLAEDVKLQ
MGYTEAIEVIQAASS
90

HR3633D-248-354-Av6HT
NFKB1
P19838
SNLKIVRMDRTAGCV
ETSEPKPFLYYPEIK
107

HR5561A-15
NFKB1
P19838
MQLVRDLLEVTSGLI
GADPLVENFEPLYDL
201

HR4541C-445-696-14
NFKB2
Q00653
MEYNARLFGLAQRSA
TLTRLLLKAGADIHA
253

HR4541C-477-696-14
NFKB2
Q00653
MQRHLLTAQDENGDT
TLTRLLLKAGADIHA
221

HR4541C-482-696-14
NFKB2
Q00653
MTAQDENGDTPLHLA
TLTRLLLKAGADIHA
216

HR4541D-37-329-TEV
NFKB2
Q00653
GPYLVIVEQPKQRGF
GDVSDSKQFTYYPLV
293

HR6920A-980-1063-NHT
NFX1
Q12986
SKFSDSLKEDARKDL
DSEPKRNVVVTAIRG
84

HR6427-1-270-14
NFYA
P23511
MEQYTANSNSSTEQI
GAEMLEEEPLYVNAK
270

HR6427-1-290-14
NFYA
P23511
MEQYTANSNSSTEQI
LKRRQARAKLEAEGK
290

HR6427-1-295-14
NFYA
P23511
MEQYTANSNSSTEQI
ARAKLEAEGKIPKER
295

HR6427A-38-145-14
NFYA
P23511
EAQVASASGQQVQTL
QIIIQQPQTAVTAGQ
108

HR6427A-42-150-14
NFYA
P23511
ASASGQQVQTLQVVQ
QPQTAVTAGQTQTQQ
109

HR6427A-47-145-14
NFYA
P23511
QQVQTLQVVQGQPLM
QIIIQQPQTAVTAGQ
99

HR4613B-51-143-TEV
NFYB
P25208
SFREQDIYLPIANVA
SYVEPLKLYLQKFRE
93

HR3512B-166-288-15
NKRF
O15226
VVAEKQYFIEKLTAT
LQKRIEVRVVRRKFK
123

HR3512B-166-293-15
NKRF
O15226
VVAEKQYFIEKLTAT
EVRVVRRKFKHTFGE
128

HR3512B-188-288-15
NKRF
O15226
PEMTSGSDKINYTYM
LQKRIEVRVVRRKFK
101

HR4600-161-227-Av6HT
NKX2-1
P43699
RRKRVLFSQAQVYE
RYKMKRQAKDKAAQQ
67

HR7114A-123-196-TEV
NKX2-2
O95096
GDAGKKRKRRVLFSK
KMKRARAEKGMEVTP
74

HR4758B-148-211-TEV
NKX2-3
Q8TAU0
RRKPRVLFSQAQVFE
QNRRYKCKRQRQDKS
64

HR7998A-189-255-TEV
NKX2-4
Q9H2Z4
RRKRRVLFSQAQVYE
RYKMKRQAKDKAAQQ
67

HR5518A-127-207-14
NKX2-5
P52952
MADNAERPRARRRRK
CKRQRQDQTLELVGL
82

HR5518A-127-207-Av6HT
NKX2-5
P52952
ADNAERPRARRRRKP
CKRQRQDQTLELVGL
81

HR5518A-127-207-TEV
NKX2-5
P52952
ADNAERPRARRRRKP
CKRQRQDQTLELVGL
81

HR5518A-14
NKX2-5
P52952
MRPRARRRRKPRVLF
DQTLELVGLPPPPPP
83

HR5518A-15
NKX2-5
P52952
MRPRARRRRKPRVLF
DQTLELVGLPPPPPP
83

HR5518B-128-224-14
NKX2-5
P52952
MDNAERPRARRRRKP
PPPPPARRIAVPVLV
98

HR5518B-128-233-14
NKX2-5
P5295
MDNAERPRARRRRKP
AVPVLVRDGKPCLGD
107

HR5518B-143-224-14
NKX2-5
P52952
MVLFSQAQVYELERR
PPPPPARRIAVPVLV
83

HR5518B-143-228-14
NKX2-5
P52952
MVLFSQAQVYELERR
PARRIAVPVLVRDGK
87

HR5518B-143-233-14
NKX2-5
P52952
MVLFSQAQVYELERR
AVPVLVRDGKPCLGD
92

HR7861A-83-143-TEV
NKX2-8
O15522
KRKKRRVLFSKAQTL
KIWFQNHRYKLKRAR
61

HR6470A-127-195-15
NKX3-1
Q99801
SRAAFSHTQVIELER
RKQLSSELGDLEKHS
69

HR6470A-132-189-15
NKX3-1
Q99801
SHTQVIELERKFSHQ
RRYKTKRKQLSSELG
58

HR6470A-97-163-15
NKX3-1
Q99801
RHLGSYLLDSENTSG
LSAPERAHLAKNLKL
67

HR6470A-97-168-15
NKX3-1
Q99801
RHLGSYLLDSENTSG
RAHLAKNLKLTETQV
72

HR6470A-97-189-15
NKX3-1
Q99801
RHLGSYLLDSENTSG
RRYKTKRKQLSSELG
93

HR6470A-97-195-15
NKX3-1
Q99801
RHLGSYLLDSENTSG
RKQLSSELGDLEKHS
99

HR8303A-212-271-Av6HT
NKX3-2
P78367
AFSHAQVFELERRFN
RRYKTKRRQMAADLL
60

HR6930A-227-296-NHT
NKX6-1
P78426
SILLDKDGKRKHTRP
VWFQNRRTKWRKKHA
70

HR7948A-199-323-Av6HT
NOC3L
Q8WTT2
TIEEHLIERKKKLQE
LENLEQMVKDWKQRK
125

HR8350A-301-458-Av6HT
NOC4L
Q9BVI4
GGALSLLALNGLFIL
HYHPEVSKAASVINQ
158

HR6913A-130-201-NHT
NPAS1
Q99742
VSEVFEQHLGGHILQ
HPGDHSEVLEQLGLR
72

HR8115A-87-146-Av6HT
NPAS2
Q99743
QLMLEALDGFIIAVT
FLPEQEHSEVYKILS
60

HR7386A-142-213-NHT
NPAS3
Q8IXF0
AIEVFEAHLGSHILQ
HPGDHVEMAEQLGMK
72

HR7814A-184-329-NHT
NPAS4
Q8IUM7
GNPVFTAFCAPLEPR
SDMEAWSLRQQINSE
146

HR7372A-210-470-15
NR0B1
P51843
MGSTLYCVPTSTNQA
VSMDDMMLEMLCTKI
262

HR7372A-210-470-Av6HT
NR0B1
P51843
GSTLYCVPTSTNQAQ
VSMDDMMLEMLCTKI
261

HR7372A-210-470-TEV
NR0B1
P51843
GSTLYCVPTSTNQAQ
VSMDDMMLEMLCTKI
261

HR7372A-237-470-15
NR0B1
P51843
MDTSSGALRPVALKS
VSMDDMMLEMLCTKI
235

HR7372A-237-470-Av6HT
NR0B1
P51843
DTSSGALRPVALKSP
VSMDDMMLEMLCTKI
234

HR7372A-237-470-TEV
NR0B1
P51843
DTSSGALRPVALKSP
VSMDDMMLEMLCTKI
234

HR7372A-245-470-15
NR0B1
P51843
MPVALKSPQVVCEAA
VSMDDMMLEMLCTKI
227

HR7372A-245-470-Av6HT
NR0B1
P51843
PVALKSPQVVCEAAS
VSMDDMMLEMLCTKI
226

HR7372A-245-470-TEV
NR0B1
P51843
PVALKSPQVVCEAAS
VSMDDMMLEMLCTKI
226

HR8369A-14-257-15
NR0B2
Q15466
MAASRPAILYALLSS
DVDIAGLLGDMLLLR
245

HR8278A-123-216-15
NR1D1
P20393
MTKLNGMVLLCKVCG
AVRFGRIPKREKQRM
95

HR8278A-123-216-Av6HT
NR1D1
P20393
TKLNGMVLLCKVCGD
AVRFGRIPKREKQRM
94

HR8278A-123-216-TEV
NR1D1
P20393
TKLNGMVLLCKVCGD
AVRFGRIPKREKQRM
94

HR8341A-100-171-15
NR1D2
Q14995
MVLLCKVCGDVASGF
QQCRFKKCLSVGMSR
73

HR8341A-100-171-Av6HT
NR1D2
Q14995
VLLCKVCGDVASGFH
QQCRFKKCLSVGMSR
72

HR8341A-100-171-TEV
NR1D2
Q14995
VLLCKVCGDVASGFH
QQCRFKKCLSVGMSR
72

HR8341A-100-181-15
NR1D2
Q14995
MVLLCKVCGDVASGF
VGMSRDAVRFGRIPK
83

HR8341A-100-181-Av6HT
NR1D2
Q14995
VLLCKVCGDVASGFH
VGMSRDAVRFGRIPK
82

HR8341A-100-181-TEV
NR1D2
Q14995
VLLCKVCGDVASGFH
VGMSRDAVRFGRIPK
82

HR8341A-100-200-15
NR1D2
Q14995
MVLLCKVCGDVASGF
RMLIEMQSAMKTMMN
102

HR8341A-100-200-Av6HT
NR1D2
Q14995
VLLCKVCGDVASGFH
RMLIEMQSAMKTMMN
101

HR8341A-100-200-TEV
NR1D2
Q14995
VLLCKVCGDVASGFH
RMLIEMQSAMKTMMN
101

HR8341B-381-579-15
NR1D2
Q14995
MHLVCPMSKSPYVDP
NNMHSEELLAFKVHP
200

HR8341B-381-579-Av6HT
NR1D2
Q14995
HLVCPMSKSPYVDPH
NNMHSEELLAFKVHP
199

HR8341B-381-579-TEV
NR1D2
Q14995
HLVCPMSKSPYVDPH
NNMHSEELLAFKVHP
199

HR7370A-209-460-15
NR1H2
P55055
MSQGSGEGEGVQLTA
DKKLPPLLSEIWDVH
253

HR7370A-209-460-Av6HT
NR1H2
P55055
SQGSGEGEGVQLTAA
DKKLPPLLSEIWDVH
252

HR7370A-209-460-TEV
NR1H2
P55055
SQGSGEGEGVQLTAA
DKKLPPLLSEIWDVH
252

HR8107E-205-447-TEV
NR1H3
Q13133
QLSPEQLGMIEKLVA
KKLPPLLSEIWDVHE
243

HR4469B-125-217-14
NR1H4
Q96RI1
MGASAGRIKGDELCV
LAECMYTGLLTEIQC
94

HR4469B-125-234-14
NR1H4
Q96RI1
MGASAGRIKGDELCV
KRLRKNVKQHADQTV
111

HR4469B-129-217-14
NR1H4
Q96RI1
MGRIKGDELCVVCGD
LAECMYTGLLTEIQC
90

HR4469B-129-234-14
NR1H4
Q96RI1
MGRIKGDELCVVCGD
KRLRKNVKQHADQTV
107

HR4469B-130-213-14
NR1H4
Q96RI1
MRIKGDELCVVCGDR
EMGMLAECMYTGLLT
85

HR4469B-130-229-14
NR1H4
Q96RI1
MRIKGDELCVVCGDR
IQCKSKRLRKNVKQH
101

HR4469B-134-213-14
NR1H4
Q96RI1
MDELCVVCGDRASGY
EMGMLAECMYTGLLT
81

HR4469B-134-229-14
NR1H4
Q96RI1
MDELCVVCGDRASGY
IQCKSKRLRKNVKQH
97

HR7870A-37-107-15
NR1I2
O75469
MGPQJCRVCGDKATG
QCQACRLRKCLESGM
72

HR7870A-37-107-Av6HT
NR1I2
O75469
GPQICRVCGDKATGY
QCQACRLRKCLESGM
71

HR7870A-37-107-TEV
NR1I2
O75469
GPQICRVCGDKATGY
QCQACRLRKCLESGM
71

HR7870A-37-130-15
NR1I2
O75469
MGPQICRVCGDKATG
EAVEERRALIKRKKS
95

HR7870A-37-130-Av6HT
NR1I2
O75469
GPQICRVCGDKATGY
EAVEERRALIKRKKS
94

HR7870A-37-130-TEV
NR1I2
O75469
GPQICRVCGDKATGY
EAVEERRALIKRKKS
94

HR7870B-130-434-15
NR1I2
O75469
MSERTGTQPLGVQGL
FATPLMQELFGITGS
306

HR7870B-130-434-Av6HT
NR1I2
O75469
SERTGTQPLGVQGLT
FATPLMQELFGITGS
305

HR7870B-130-434-TEV
NR1I2
O75469
SERTGTQPLGVQGLT
FATPLMQELFGITGS
305

HR7870C-142-434-15
NR1I2
O75469
MGLTEEQRMMIRELM
FATPLMQELFGITGS
294

HR7870C-142-434-Av6HT
NR1I2
O75469
GLTEEQRMMIRELMD
FATPLMQELFGITGS
293

HR7870C-142-434-TEV
NR1I2
O75469
GLTEEQRMMIRELMD
FATPLMQELFGITGS
293

HR7475A-6-105-15
NR1I3
Q14994
MDELRNCVVCGDQAT
RAKQAQRRAQQTPVQ
101

HR7475A-6-105-Av6HT
NR1I3
Q14994
DELRNCVVCGDQATG
RAKQAQRRAQQTPVQ
100

HR7475A-6-105-TEV
NR1I3
Q14994
DELRNCVVCGDQATG
RAKQAQRRAQQTPVQ
100

HR7475A-6-120-15
NR1I3
Q14994
MDELRNCVVCGDQAT
LSKEQEELIRTLLGA
116

HR7475A-6-120-Av6HT
NR1I3
Q14994
DELRNCVVCGDQATG
LSKEQEELIRTLLGA
115

HR7475A-6-120-TEV
NR1I3
Q14994
DELRNCVVCGDQATG
LSKEQEELIRTLLGA
115

HR7475B-6-77-15
NR1I3
Q14994
MDELRNCVVCGDQAT
CPACRLQKCLDAGMR
73

HR7475B-6-77-Av6HT
NR1I3
Q14994
DELRNCVVCGDQATG
CPACRLQKCLDAGMR
72

HR7475B-6-77-TEV
NR1I3
Q14994
DELRNCVVCGDQATG
CPACRLQKCLDAGMR
72

HR7475B-6-82-15
NR1I3
Q14994
MDELRNCVVCGDQAT
LQKCLDAGMRKDMIL
78

HR7475B-6-82-Av6HT
NR1I3
Q14994
DELRNCVVCGDQATG
LQKCLDAGMRKDMIL
77

HR7475B-6-82-TEV
NR1I3
Q14994
DELRNCVVCGDQATG
LQKCLDAGMRKDMIL
77

HR7475C-103-352-15
NR1I3
Q14994
MPVQLSKEQEELIRT
QGLSAMMPLLQEICS
251

HR7475C-103-352-Av6HT
NR1I3
Q14994
PVQLSKEQEELIRTL
QGLSAMMPLLQEICS
250

HR7475C-103-352-TEV
NR1I3
Q14994
PVQLSKEQEELIRTL
QGLSAMMPLLQEICS
250

HR8155A-108-196-Av6HT
NR2C1
P13056
KVFDLCVVCGDKASG
SVQCERKPIEVSREK
89

HR6956-16-584-15
NR2C2
P49116
MAVASPQRIQGSEPA
RLMSSNITEELFFTG
570

HR6956-16-584-Av6HT
NR2C2
P49116
AVASPQRIQGSEPAS
RLMSSNITEELFFTG
569

HR6956-16-584-TEV
NR2C2
P49116
AVASPQRIQGSEPAS
RLMSSNITEELFFTG
569

HR6956A-115-584-15
NR2C2
P49116
MSASVERLLGKTDVQ
RLMSSNITEELFFTG
471

HR6956A-115-584-TEV
NR2C2
P49116
SASVERLLGKTDVQR
RLMSSNITEELFFTG
470

HR6956B-170-584-15
NR2C2
P49116
MYSCRSNQDCIINKH
RLMSSNITEELFFTG
416

HR6956B-170-584-Av6HT
NR2C2
P49116
YSCRSNQDCIINKHH
RLMSSNITEELFFTG
415

HR6956B-170-584-TEV
NR2C2
P49116
YSCRSNQDCIINKHH
RLMSSNITEELFFTG
415

HR6956B-181-584-15
NR2C2
P49116
MNKHHRNRCQFCRLK
RLMSSNITEELFFTG
405

HR6956B-181-584-Av6HT
NR2C2
P49116
NKHHRNRCQFCRLKK
RLMSSNITEELFFTG
404

HR6956B-181-584-TEV
NR2C2
P49116
NKHHRNRCQFCRLKK
RLMSSNITEELFFTG
404

HR6956B-218-584-15
NR2C2
P49116
MEKPSNCAASTEKIY
RLMSSNITEELFFTG
368

HR6956B-218-584-Av6HT
NR2C2
P49116
EKPSNCAASTEKIYI
RLMSSNITEELFFTG
367

HR6956B-218-584-TEV
NR2C2
P49116
EKPSNCAASTEKIYI
RLMSSNITEELFFTG
367

HR6956C-110-188-15
NR2C2
P49116
MQIVTDSASVERLLG
SNQDCIINKHHRNRC
80

HR6956C-110-205-15
NR2C2
P49116
MQIVTDSASVERLLG
CRLKKCLEMGMKMES
97

HR6956C-115-183-15
NR2C2
P49116
MSASVERLLGKTDVQ
TYSCRSNQDCIINKH
70

HR6956C-115-183-Av6HT
NR2C2
P49116
SASVERLLGKTDVQR
TYSCRSNQDCIINKH
69

HR6956C-115-183-TEV
NR2C2
P49116
SASVERLLGKTDVQR
TYSCRSNQDCIINKH
69

HR6956C-115-200-15
NR2C2
P49116
MSASVERLLGKTDVQ
NRCQFCRLKKCLEMG
87

HR6956C-115-200-Av6HT
NR2C2
P49116
SASVERLLGKTDVQR
NRCQFCRLKKCLEMG
86

HR6956C-115-200-TEV
NR2C2
P49116
SASVERLLGKTDVQR
NRCQFCRLKKCLEMG
86

HR7378A-18-385-15
NR2E1
Q9Y466
MVCGDRSSGKHYGVY
PITRLLSDMYKSSDI
369

HR7378A-18-385-Av6HT
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
PITRLLSDMYKSSDI
368

HR7378A-18-385-TEV
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
PITRLLSDMYKSSDI
368

HR7378B-134-385-Av6HT
NR2E1
Q9Y466
VTQLEPHGLELAAVS
PITRLLSDMYKSSDI
252

HR7378B-134-385-TEV
NR2E1
Q9Y466
VTQLEPHGLELAAVS
PITRLLSDMYKSSDI
252

HR7378B-65-385-15
NR2E1
Q9Y466
MTHRNQCRACRLKKC
PITRLLSDMYKSSDI
322

HR7378B-65-385-Av6HT
NR2E1
Q9Y466
THRNQCRACRLKKCL
PITRLLSDMYKSSDI
321

HR7378B-65-385-TEV
NR2E1
Q9Y466
THRNQCRACRLKKCL
PITRLLSDMYKSSDI
321

HR7378B-76-385-15
NR2E1
Q9Y466
MKKCLEVNMNKDAVQ
PITRLLSDMYKSSDI
311

HR7378B-76-385-Av6HT
NR2E1
Q9Y466
KKCLEVNMNKDAVQH
PITRLLSDMYKSSDI
310

HR7378B-76-385-TEV
NR2E1
Q9Y466
KKCLEVNMNKDAVQH
PITRLLSDMYKSSDI
310

HR7378C-18-109-15
NR2E1
Q9Y466
MVCGDRSSGKHYGVY
RTSTIRKQVALYFRG
93

HR7378C-18-109-Av6HT
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
RTSTIRKQVALYFRG
92

HR7378C-18-109-TEV
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
RTSTIRKQVALYFRG
92

HR7378C-18-83-15
NR2E1
Q9Y466
MVCGDRSSGKHYGVY
QCRACRLKKCLEVNM
67

HR7378C-18-83-Av6HT
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
QCRACRLKKCLEVNM
66

HR7378C-18-83-TEV
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
QCRACRLKKCLEVNM
66

HR7378C-18-96-15
NR2E1
Q9Y466
MVCGDRSSGKHYGVY
NMNKDAVQHERGPRT
80

HR7378C-18-96-Av6HT
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
NMNKDAVQHERGPRT
79

HR7378C-18-96-TEV
NR2E1
Q9Y466
VCGDRSSGKHYGVYA
NMNKDAVQHERGPRT
79

HR7906-Av6HT
NR2E3
Q9Y5X4
ETRPTALMSSTVAAA
NTPMEKLLCDMFKN*
410

HR7906B-101-410-Av6HT
NR2E3
Q9Y5X4
QACRLKKCLQAGMNQ
GNTPMEKLLCDMFKN
310

HR7906B-101-410-TEV
NR2E3
Q9Y5X4
QACRLKKCLQAGMNQ
GNTPMEKLLCDMFKN
310

HR7906B-114-410-15
NR2E3
Q9Y5X4
MNQDAVQNERQPRST
GNTPMEKLLCDMFKN
298

HR7906B-114-410-Av6HT
NR2E3
Q9Y5X4
NQDAVQNERQPRSTA
GNTPMEKLLCDMFKN
297

HR7906B-114-410-TEV
NR2E3
Q9Y5X4
NQDAVQNERQPRSTA
GNTPMEKLLCDMFKN
297

HR7906B-164-410-Av6HT
NR2E3
Q9Y5X4
SAARALGHHFMASLI
GNIPMEKLLCDMFKN
247

HR7906C-45-119-15
NR2E3
Q9Y5X4
MLQCRVCGDSSSGKH
LKKCLQAGMNQDAVQ
76

HR7906C-45-131-15
NR2E3
Q9Y5X4
MLQCRVCGDSSSGKH
AVQNERQPRSTAQVH
88

HR7906C-45-142-15
NR2E3
Q9Y5X4
MLQCRVCGDSSSGKH
AQVHLDSMESNTESR
99

HR7906C-50-114-15
NR2E3
Q9Y5X4
MCGDSSSGKHYGIYA
CQACRLKKCLQAGMN
66

HR7906C-50-126-15
NR2E3
Q9Y5X4
MCGDSSSGKHYGIYA
GMNQDAVQNERQPRS
78

HR7906C-50-126-Av6HT
NR2E3
Q9Y5X4
CGDSSSGKHYGIYAC
GMNQDAVQNERQPRS
77

HR7906C-50-126-TEV
NR2E3
Q9Y5X4
CGDSSSGKHYGIYAC
GMNQDAVQNERQPRS
77

HR7906C-50-135-Av6HT
NR2E3
Q9Y5X4
CGDSSSGKHYGIYAC
ERQPRSTAQVHLDSM
86

HR7906C-50-135-TEV
NR2E3
Q9Y5X4
CGDSSSGKHYGIYAC
ERQPRSTAQVHLDSM
86

HR7906D-36-410-Av6HT
NR2E3
Q9Y5X4
EDPTGVSPSLQCRVC
GNTPMEKLLCDMFKN
375

HR3061D-77-164-TEV
NR2F1
P10589
SGQSQQHIECVVCGD
GMRREAVQRGRMPPT
88

HR6377A-77-157-TEV
NR2F2
P24468
IECVVCGDKSSGKHY
GMRREAVQRGRMPPT
81

HR7636A-56-394-Av6HT
NR2F6
P10588
CVVCGDKSSGKHYGV
TPIETLIRDMLLSGS
339

HR7636A-56-394-TEV
NR2F6
P10588
CVVCGDKSSGKHYGV
TPIETLIRDMLLSGS
339

HR7636B-113-394-15
NR2F6
P10588
MLKKCFRVGMRKEAV
TPIETLIRDMLLSGS
283

HR7636B-113-394-Av6HT
NR2F6
P10588
LKKCFRVGMRKEAVQ
TPIETLIRDMLLSGS
282

HR7636B-113-394-TEV
NR2F6
P10588
LKKCFRVGMRKEAVQ
TPIETLIRDMLLSGS
282

HR7636B-159-394-Av6HT
NR2F6
P10588
DLFPGQPVSELIAQL
TPIETLIRDMLLSGS
236

HR7636B-159-394-TEV
NR2F6
P10588
DLFPGQPVSELIAQL
TPIETLIRDMLLSGS
236

HR7636C-56-133-15
NR2F6
P10588
MCVVCGOKSSGKHYG
VGMRKEAVQRGRIPH
79

HR4533-15
NR3C1
P04150
MDSKESLTPGREENP
KYSNGNIKKLLFHQK
777

HR7785-601-673-15
NR3C2
P08235
MKICLVCGDEASGCH
RLQKCLQAGMNLGAR
74

HR7785A-601-673-Av6HT
NR3C2
P08235
KICLVCGDEASGCHY
RLQKCLQAGMNLGAR
73

HR7785A-601-673-TEV
NR3C2
P08235
KICLVCGDEASGCHY
RLQKCLQAGMNLGAR
73

HR7785A-601-685-15
NR3C2
P08235
MKICLVCGDEASGCH
GARKSKKLGKLKGIH
86

HR7785A-601-685-Av6HT
NR3C2
P08235
KICLVCGDEASGCHY
GARKSKKLGKLKGIH
85

HR7785A-601-685-TEV
NR3C2
P08235
KICLVCGDEASGCHY
GARKSKKLGKLKGIH
85

HR7785B-712-984-15
NR3C2
P08235
MAPAKEPSVNTALVP
KVESGNAKPLYFHRK
274

HR7785B-712-984-Av6HT
NR3C2
P08235
APAKEPSVNTALVPQ
KVESGNAKPLYFHRK
273

HR7785B-712-984-TEV
NR3C2
P08235
APAKEPSVNTALVPQ
KVESGNAKPLYFHRK
273

HR7785C-731-984-Av6HT
NR3C2
P08235
SRALTPSPVMVLENI
KVESGNAKPLYFHRK
254

HR7785C-731-984-TEV
NR3C2
P08235
SRALTPSPVMVLENI
KVESGNAKPLYFHRK
254

HR4793B-265-353-TEV
NR4A1
P22736
GRCAVCGDNASCQHY
TDSLKGRRGRLPSKP
89

HR8241A-261-342-15
NR4A2
P43354
MGLCAVCGDNAACQH
MVKEVVRTDSLKGRR
83

HR8241A-261-342-Av6HT
NR4A2
P43354
GLCAVCGDNAACQHY
MVKEVVRTDSLKGRR
82

HR8241A-261-342-TEV
NR4A2
P43354
GLCAVCGDNAACQHY
MVKEVVRTDSLKGRR
82

HR8241A-264-328-15
NR4A2
P43354
MAVCGDNAACQHYGV
RCQYCRFQKCLAVGM
66

HR8241A-264-328-Av6HT
NR4A2
P43354
AVCGDNAACQHYGVR
RCQYCRFQKCLAVGM
65

HR8241A-264-328-TEV
NR4A2
P43354
AVCGDNAACQHYGVR
RCQYCRFQKCLAVGM
65

HR8241B-328-598-15
NR4A2
P43354
MVKEVVRTDSLKGRR
PPAIIDKLFLDTLPF
271

HR8241B-328-598-Av6HT
NR4A2
P43354
VKEVVRTDSLKGRRG
PPAIIDKLFLDTLPF
270

HR8241B-328-598-TEV
NR4A2
P43354
VKEVVRTDSLKGRRG
PPAIIDKLFLDTLPF
270

HR7224A-291-626-15
NR4A3
Q92570
MTCAVCGDNAACQHY
PPSIIDKLFLDTLPF
337

HR7224B-363-626-15
NR4A3
Q92570
MRTDSLKGRRGRLPS
PPSIIDKLFLDTLPF
265

HR7224B-363-626-Av6HT
NR4A3
Q92570
RTDSLKGRRGRLPSK
PPSIIDKLFLDTLPF
264

HR7224B-363-626-TEV
NR4A3
Q92570
RTDSLKGRRGRLPSK
PPSIIDKLFLDTLPF
264

HR7224B-396-626-15
NR4A3
Q92570
MICMMNALVRALTDS
PPSIIDKLFLDTLPF
232

HR7224B-396-626-Av6HT
NR4A3
Q92570
ICMMNALVRALTDST
PPSIIDKLFLDTLPF
231

HR7224B-396-626-TEV
NR4A3
Q92570
ICMMNALVRALTDST
PPSIIDKLFLDTLPF
231

HR7224B-411-626-15
NR4A3
Q92570
MPRDLDYSRYCPTDQ
PPSIIDKLFLDTLPF
217

HR7224B-411-626-Av6HT
NR4A3
Q92570
PRDLDYSRYCPTDQA
PPSIIDKLFLDTLPF
216

HR7224B-411-626-TEV
NR4A3
Q92570
PRDLDYSRYCPTDQA
PPSIIDKLFLDTLPF
216

HR7224C-291-374-15
NR4A3
Q92570
MTCAVCGDNAACQHY
EVVRTDSLKGRRGRL
85

HR7224C-291-374-Av6HT
NR4A3
Q92570
TCAVCGDNAACQHYG
EVVRTDSLKGRRGRL
84

HR7224C-291-374-TEV
NR4A3
Q92570
TCAVCGDNAACQHYG
EVVRTDSLKGRRGRL
84

HR7224C-294-356-15
NR4A3
Q92570
MVCGDNAACQHYGVR
NRCQYCRFQKCLSVG
64

HR7224C-294-356-Av6HT
NR4A3
Q92570
VCGDNAACQHYGVRT
NRCQYCRFQKCLSVG
63

HR7224C-294-356-TEV
NR4A3
Q92570
VCGDNAACQHYGVRT
NRCQYCRFQKCLSVG
63

HR7993A-220-461-15
NR5A1
Q13285
MGPNVPELILQLLQL
PRNNLLIEMLQAKQT
243

HR7993A-220-461-Av6HT
NR5A1
Q13285
GPNVPELILQLLQLE
PRNNLLIEMLQAKQT
242

HR7993A-220-461-TEV
NR5A1
Q13285
GPNVPELILQLLQLE
PRNNLLIEMLQAKQT
242

HR7993B-10-111-15
NR5A1
O13285
MDELCPVCGDKVSGY
PMYKRDRALKQQKKA
103

HR7993B-10-111-Av6HT
NR5A1
Q13285
DELCPVCGDKVSGYH
PMYKRDRALKQQKKA
102

HR7993B-10-111-TEV
NR5A1
Q13285
DELCPVCGDKVSGYH
PMYKRDRALKQQKKA
102

HR8211A-79-187-Av6HT
NR5A2
O00482
MDEDLEELCPVCGDK
KRDRALKQQKKALIR
110

HR8211A-79-187-NHT
NR5A2
O00482
DEDLEELCPVCGDKV
KRDRALKQQKKALIR
109

HR8211A-79-187-TEV
NR5A2
O00482
DEDLEELCPVCGDKV
KRDRALKQQKKALIR
109

HR7049A-49-474-15
NR6A1
Q15406
MDRAEQRTCLICGDR
LFKVVLHSCKTSVGK
427

HR7049A-49-474-Av6HT
NR6A1
Q15406
DRAEQRTCLICGDRA
LFKVVLHSCKTSVGK
426

HR7049A-49-474-TEV
NR6A1
Q15406
DRAEQRTCLICGDRA
LFKVVLHSCKTSVGK
426

HR7049B-117-474-15
NR6A1
Q15406
MLQMGMNRKAIREDG
LFKVVLHSCKTSVGK
359

HR7049B-117-474-Av6HT
NR6A1
Q15406
LQMGMNRKAIREDGM
LFKVVLHSCKTSVGK
358

HR7049B-117-474-TEV
NR6A1
Q15406
LQMGMNRKAIREDGM
LFKVVLHSCKTSVGK
358

HM7049C-49-143-15
NR6A1
Q15406
MDRAEQRTCLICGDR
DGMPGGRNKSIGPVQ
96

HR7049C-49-143-Av6HT
NR6A1
Q15406
DRAEQRTCLICGDRA
DGMPGGRNKSIGPVQ
95

HR7049C-49-143-TEV
NR6A1
Q15406
DRAEQRTCLICGDRA
DGMPGGRNKSIGPVQ
95

HR7049C-49-159-15
NR6A1
Q15406
MDRAEQRTCLICGDR
SEEEIERIMSGQEFE
112

HR7049C-49-159-Av6HT
NR6A1
Q15406
DRAEQRTCLICGDRA
SEEEIERIMSGQEFE
111

HR7049C-49-159-TEV
NR6A1
Q15406
DRAEQRTCLICGDRA
SEEEIERIMSGQEFE
111

HR7049C-58-143-15
NR6A1
Q15406
MICGDRATGLHYGII
DGMPGGRNKSIGPVQ
87

HR7049C-58-159-15
NR6A1
Q15406
MICGDRATGLHYGII
SEEEIERIMSGQEFE
103

HR7049C-58-159-Av6HT
NR6A1
Q15406
ICGDRATGLHYGIIS
SEEEIERIMSGQEFE
102

HR7049C-58-159-TEV
NR6A1
Q15406
ICGDRATGLHYGIIS
SEEEIERIMSGQEFE
102

HR8346A-59-490-Av6HT
NRF1
Q16656
LNSTAADEVTAHLAA
AMAPVTTRISDSAVT
432

HR7765A-130-171-Av6HT
NRL
P54845
ERFSDAALVSMSVRE
ALRLKQRRRTLKNRG
42

HR8036A-96-176-Av6HT
OLIG1
Q8TAK6
PDAKEEQQQQLRRKI
LLLGSSLQELRRALG
81

HR7010A-102-190-15
OLIG2
Q13516
MTEPELQQLRLKINS
IYGGHHAGFHPSACG
90

HR7010A-136-190-15
OLIG2
Q13516
MPYAHGPSVRKLSKI
IYGGHHAGFHPSACG
56

HR7010A-97-191-15
OLIG2
Q13516
MDKKQMTEPELQQLR
YGGHHAGFHPSACGG
96

HR6912A-76-168-NHT
OLIG3
Q7RTU3
LSEQDLQQLRLKING
GHHSAFHCGTVGHSA
93

HR4667C-291-437-TEV
ONECUT1
Q9UBC0
EINTKEVAQRITTEL
GLELSTVSNFFMNAR
147

HR8108A-313-459-TEV
ONECUT2
O95948
ERPPSSSSGSQVATS
FKENKRPSKEMQITI
147

HR7555A-320-466-TEV
ONECUT3
O60422
EINTKEVAQRITAEL
GLELNTVSNFFMNAR
147

HR8321A-165-256-TEV
OSR1
Q8TAX0
GRLPSKTKKEFVCKF
QSRTLAVHKTLHSQV
92

HR6892A-160-254-TEV
OSR2
Q8N2R0
SRGRLPSKTKKEFIC
SRTLAVHKTLHMQES
95

HR7032A-39-109-TEV
OTX1
P32242
RRERTTFTRSQLDVL
QQQQSGSGTKSRPAK
71

HR7869A-39-106-TEV
OTX2
P32243
PAATPRKQRRERTTF
VWFKNRRAKCRQQQQ
68

HR8136A-96-170-Av6HT
OVOL1
O14753
RDHGFLRTKMKVTLG
NDTFDLKRHVRTHTG
75

HR8149A-102-172-Av6HT
OVOL2
Q9BRP0
ARSKIKFTTGTCSDS
DTFDLKRHVRTHTGI
71

HR8517-1-166-Av6HT
OVOL3
O00110
PRAFLVRSRRPQPPN
YRERREKLHVCEDCG
165

HR6980A-489-684-TEV
PARP12
Q9H0J9
DSSALPDPGFQKITL
YPEYVIQYTTSSKPS
196

HR8222A-355-438-TEV
PATZ1
Q9HBE1
VACEICGKIFRDVYH
RPDHLNGHIKQVHTS
84

HR7455A-96-228-NHT
PAX1
P15863
EQTYGEVNQLGGVFV
VSSISRILRNKIGSL
133

HR7856A-1-149-TEV
PAX5
Q02548
DLEKNYPTPRTSRTG
INRIIRTKVQQPPNQ
148

HR8074A-4-136-TEV
PAX6
P26367
SHSGVNQLGGVFVNG
SINRVLRNLASEKQQ
133

HR7676A-217-276-TEV
PAX7
P23759
QRRSRTTFTAEQLEE
QVWFSNRRARWRKQA
60

HR7297A-1-146-TEV
PAX8
Q06710
PHNSIRSGHGGLNQL
IRTKVQQPFNLPMDS
145

HR7882A-388-494-TEV
PBRM1
Q86U86
YYQQIKMPISLQQIR
RKSKKNIRKQRMKIL
107

HR7526A-233-295-TEV
PBX1
P40424
ARRKRRNFNKQATEI
SNWFGNKRIRYKKNI
63

HR7154A-244-306-TEV
PBX2
P40425
ARRKRRNFSKQATEV
SNWFGNKRIRYKKNI
63

HR7892A-235-297-Av6HT
PBX3
P40426
KTAVTAAHAVAAAVQ
NGDSYQGSQVGANVQ
63

HR7892A-235-297-TEV
PBX3
P40426
KTAVTAAHAVAAAVQ
NGDSYQGSQVGANVQ
63

HR7406A-210-272-Av6HT
PBX4
Q9BYU1
MARRKRRNFSKQATE
SNWFGNKRIRYKKNM
64

HR7406A-210-272-TEV
PBX4
Q9BYU1
ARRKRRNFSKQATEV
SNWFGNKRIRYKKNM
63

HR7140A-124-182-TEV
PCGF6
Q9BYE7
NLSELTPYILCSICK
RCPKCNIVVHQTQPL
59

HR7140B-130-350-TEV
PCGF6
Q9BYE7
PYILCSICKGYLIDA
LVLHYGLVVSPLKIT
221

HR7140B-134-350-TEV
PCGF6
Q9BYE7
CSICKGYLIDATTIT
LVLHYGLVVSPLKIT
217

HR7140B-143-350-TEV
PCGF6
Q9BYE7
DATTITECLHTFCKS
LVLHYGLVVSPLKIT
208

HR7140B-182-350-TEV
PCGF6
Q9BYE7
LYNIRLDRQLQDIVY
LVLHYGLVVSPLKIT
169

HT6303A-249-350-Av6HT
PCGF6
Q9BYE7
IPPELDMSLLLEFIG
GLLVLHYGLVVSPLK
102

HT6303A-249-350-TEV
PCGF6
Q9BYE7
IPPELDMSLLLEFIG
GLLVLHYGLVVSPLK
102

HR7628A-146-206-TEV
PDX1
P52945
NKRTRTAYTRAQLLE
IWFQNRRMKWKKEED
61

HR4675D-563-641-TEV
PGR
P06401
PQKICLICGDEASGC
CCQAGMVLGGRKFKK
79

HR6832-1-194-15
PHB2
Q99623
MAQNLKDLAGRLPAG
DDVAITELSFSREYT
194

HR6832-1-194-Av6HT
PHB2
Q99623
AQNLKDLAGRLPAGP
DDVAITELSFSREYT
193

HR6832-1-291-15
PHB2
Q99623
MAQNLKDLAGRLPAG
NLVLNLQDESFTRGS
291

HR6832-1-291-Av6HT
PHB2
Q99623
AQNLKDLAGRLPAGP
NLVLNLQDESFTRGS
290

HR6832-15
PHB2
Q99623
MAQNLKDLAGRLPAG
SFTRGSDSLIKGKK*
300

HR6832-33-299-15
PHB2
Q99623
MAYGVRESVFTVEGG
ESFTRGSDSLIKGKK
268

HR6832-33-299-Av6HT
PHB2
Q99623
AYGVRESVFTVEGGH
ESFTRGSDSLIKGKK
267

HR6832-38-299-15
PHB2
Q99623
MESVFTVEGGHRAIF
ESFTRGSDSLIKGKK
263

HR6832-38-299-Av6HT
PHB2
Q99623
ESVFTVEGGHRAIFF
ESFTRGSDSLIKGKK
262

HR6832-Av6HT
PHB2
Q99623
AQNLKDLAGRLPAGP
SFTRGSDSLIKGKK*
299

HR6832A-33-194-15
PHB2
Q99623
MAYGVRESVFTVEGG
DDVAITELSFSREYT
163

HR6832A-33-194-Av6HT
PHB2
Q99623
AYGVRESVFTVEGGH
DDVAITELSFSREYT
162

HR6832A-33-207-15
PHB2
Q99623
MAYGVRESVFTVEGG
YTAAVEAKQVAQQEA
176

HR6832A-33-207-Av6HT
PHB2
Q99623
AYGVRESVFTVEGGH
YTAAVEAKQVAQQEA
175

HR6832A-33-207-NHT
PHB2
Q99623
AYGVRESVFTVEGGH
YTAAVEAKQVAQQEA
175

HR6832A-72-194-15
PHB2
Q99623
MIPWFQYPIIYDIRA
DDVAITELSFSREYT
124

HR6832A-72-194-Av6HT
PHB2
Q99623
IPWFQYPIIYDIRAR
DDVAITELSFSREYT
123

HR6832A-72-207-15
PHB2
Q99623
MIPWFQYPIIYDIRA
YTAAVEAKQVAQQEA
137

HR6832A-72-207-Av6HT
PHB2
Q99623
IPWFQYPIIYDIRAR
YTAAVEAKQVAQQEA
136

HR7710A-641-719-NHT
PHF20
Q9BVI0
ELDGDDRYDFEVVRC
PGFKYWYDKEWLSRG
79

HR6973A-486-543-TEV
PHF21A
Q96BD5
IHEDFCSVCRKSGQL
CPRCQDQMLKKEEAI
58

HR6412A-62-149-14
PHOX2A
O14813
LRDHQPAPYSAVPYK
QVWFQNRRAKFRKQE
88

HR6412A-67-144-14
PHOX2A
O14813
PAPYSAVPYKFFPEP
TEARVQVWFQNRRAK
78

HR6412B-71-149-14
PHOX2A
O14813
SAVPYKFFPEPSGLH
QVWFQNRRAKFRKQE
79

HR6412B-76-144-14
PHOX2A
O14813
KFFPEPSGLHEKRKQ
TEARVQVWFQNRRAK
69

HR7334A-91-148-Av6HT
PHOX2B
Q99453
GLNEKRKQRRIRTTF
KIDLTEARVQVWFQN
58

HR8156A-1-65-TEV
PIAS1
O75925
ADSAELKQMVMSLRV
PAVQMKIKELYRRRP
64

HR7952-96-424-Av6HT
PIAS2
O75928
LAVAGIHSLPSTSVT
CSDVDEIKFQEDGSW
329

HR3483-121-628-14
PIAS3
Q9Y6X2
MQPVHPDVTMKPLPF
GPSLTGCRSDIISLD
509

HR3483-126-628-14
PIAS3
Q9Y6X2
MDVTMKPLPFYEVYG
GPSLTGCRSDIISLD
504

HR3042-1-425-14
PIAS4
Q8N2W9
MAAELVEAKNMVMSF
KERSCSPQGAILVLG
425

HR3042A-1-55-14
PIAS4
Q8N2W9
MAAELVEAKNMVMSF
RALQLVQFDCSPELF
55

HR3042A-1-68-14
PIAS4
Q8N2W9
MAAELVEAKNMVMSF
LFKKIKELYETRYAK
68

HR3042A-1-73-14
PIAS4
Q8N2W9
MAAELVEAKNMVMSF
KELYETRYAKKNSEP
73

HR7108A-119-222-Av6HT
PIKFYVE
Q9Y2I7
GHDPRTAVQLRSLST
RACTYCRKIALSYAH
104

HR7108A-119-241-Av6HT
PIKFYVE
Q9Y2I7
GHDPRTAVQLRSLST
NSIGEDLNALSDSAC
123

HR7108A-143-222-Av6HT
PIKFYVE
Q9Y2I7
EGKSQDSDLKQYWMP
RACTYCRKIALSYAH
80

HR7108A-143-241-Av6HT
PIKFYVE
Q9Y2I7
EGKSQDSDLKQYWMP
NSIGEDLNALSDSAC
99

HR7108A-150-222-Av6HT
PIKFYVE
Q9Y2I7
DLKQYWMPDSQCKEC
RACTYCRKIALSYAH
73

HR7108A-150-241-NHT
PIKFYVE
Q9Y2I7
DLKQYWMPDSQCKEC
NSIGEDLNALSDSAC
92

HR7108B-586-943-Av6HT
PIKFYVE
Q9Y2I7
GWHHNNLELLREENG
LLELRIVFEKGEQEN
358

HR7108B-610-943-Av6HT
PIKFYVE
Q9Y2I7
SANHNHMMALLQQLL
LLELRIVFEKGEQEN
334

HR7108C-1761-2058-Av6HT
PIKFYVE
Q9Y2I7
KRETLRGADSAYYQV
DKKLEMVVKSTGILG
298

HR7108C-1761-2088-Av6HT
PIKFYVE
Q9Y2I7
KRETLRGADSAYYQV
TRFCEAMDKYFLMVP
328

HR7108C-1807-2058-Av6HT
PIKFYVE
Q9Y2I7
PHVELQFSDANAKFY
DKKLEMVVKSTGILG
252

HR7108C-1807-2088-Av6HT
PIKFYVE
Q9Y2I7
PHVELQFSDANAKFY
TRFCEAMDKYFLMVP
282

HR7108D-342-488-Av6HT
PIKFYVE
Q9Y2I7
TEDERKILLDSVQLK
DSDTEQIAEEGDDNL
147

HR7108D-353-488-Av6HT
PIKFYVE
Q9Y2I7
VQLKDLWKKICHHSS
DSDTEQIAEEGDDNL
136

HR8214A-89-149-TEV
PITX1
P78337
QRRQRTHFTSQQLQE
VWFKNRRAKWRKRER
61

HR4722B-274-317-Av6HT
PITX2
Q99697
RDTCNSSLASLRLKA
ASNLSACQYAVDRPV
44

HR7801A-85-145-TEV
PITX3
O75364
RYPDMSTREEIAVWT
GSFAAPLGGIVPPYE
61

HR7268A-257-319-TEV
PKNOX1
P55347
GSSKNKRGVLPKHAT
QVNNWFINARRRILQ
63

HR7428A-289-348-TEV
PKNOX2
Q96KN3
KNKRGVLPKHATNIM
QVNNWFINARRRILQ
60

HR7109-1-351-15
PLAG1
Q6DJT9
MATVIPGDLSEVRDT
SSTSYAISIPEKEQP
351

HR7109-1-356-15
PLAG1
Q6DJT9
MATVIPGDLSEVRDT
AISIPEKEQPLKGEI
356

HR7109-1-368-15
PLAG1
Q6DJT9
MATVIPGDLSEVRDT
GEIESYLMELQGGVP
368

HR7109-1-436-15
PLAG1
Q6DJT9
MATVIPGDLSEVRDT
FNFIPLNGPPYNPLS
436

HR7109-1-441-15
PLAG1
Q6DJT9
MATVIPGDLSEVRDT
LNGPPYNPLSVGSLG
441

HR7109A-70-128-Av6HT
PLAG1
Q6DJT9
TKAFVSKYKLQRHMA
HDPNKETFKCEECGK
59

HR7109A-70-163-Av6HT
PLAG1
Q6DJT9
TKAFVSKYKLQRHMA
DLTCKVCLQTFESTG
94

HR7109A-72-107-Av6HT
PLAG1
Q6DJT9
AFVSKYKLQRHMATH
KCNYCEKMFHRKDHL
36

HR7109B-36-237-Av6HT
PLAG1
Q6DJT9
CQLCDKAFNSVEKLK
GRKDHLTRHMKKSHN
202

HR7109C-119-174-Av6HT
PLAG1
Q6DJT9
ETFKCEECGKNYNTK
ESTGVLLEHLKSHAG
56

HR7109C-122-170-Av6HT
PLAG1
Q6DJT9
KCEECGKNYNTKLGF
LQTFESTGVLLEHLK
49

HR7109D-183-233-Av6HT
PLAG1
Q6DJT9
KKHQCEHCDRRFYTR
AQRFGRKDHLTRHMK
51

HR7109D-183-237-Av6HT
PLAG1
Q6DJT9
KKHQCEHCDRRFYTR
GRKDHLTRHMKKSHN
55

HR7109D-188-233-Av6HT
PLAG1
Q6DJT9
EHCDRRFYTRKDVRR
AQRFGRKDHLTRHMK
46

HR7895-1-337-Av6HT
PLAGL1
Q9UM63
ATFPCQLCGKTFLTL
KGFCNISLFEDLPLQ
336

HR7895-1-397-Av6HT
PLAGL1
Q9UM63
ATFPCQLCGKTFLTL
LLGFWQLPPPATQNT
396

HR7895-159-463-Av6HT
PLAGL1
Q9UM63
DHCERCFYTRKDVRR
GTGSAILPHFHHAFR
305

HR7895-Av6HT
PLAGL1
Q9UM63
ATFPCQLCGKTFLTL
TGSAILPHFHHAFR*
463

HR7895A-149-212-15
PLAGL1
Q9UM63
MSGTKEKKHQCDHCE
HLTRHTKKTHSQELM
65

HR7895A-154-207-15
PLAGL1
Q9UM63
MKKHQCDHCERLFYT
FGRKDHLTRHTKKTH
55

HR7895A-159-199-Av6HT
PLAGL1
Q9UM63
DHCERCFYTRKDVRR
LCQFCAQRFGRKDHL
41

HR7895B-1-209-AV6HT
PLAGL1
Q9UM63
ATFPCQLCGKTFLTL
RKDHLTRHTKKTHSQ
208

HR7895C-1-69-Av6HT
PLAGL1
Q9UM63
ATFPCQLCGKTFLTL
THSPQKSHQCAHCEK
68

HR7895C-12-69-Av6HT
PLAGL1
Q9UM63
TFLTLEKFTIHNYSH
THSPQKSHQCAHCEK
58

HR7996A-189-243-Av6HT
PLAGL2
Q9UPG8
KKHPCDHCDRRFYTR
GRKDHLTRHVKKSHS
55

HR8052A-121-223-TEV
PLEK
P08567
PETIDLGALYLSMKD
FLDNPDAFYYFPDSG
103

HR7739A-238-353-TEV
PLEK2
Q9NYT0
SLSTVELSGTVVKQG
KAERAEWIEAIKKLT
116

HR7495A-45-167-TEV
PLEKHA4
Q9H4M7
NALRRDPNLPVHIRG
RAEGDDYGQPRSPAR
123

HR8545A-1266-1889-Av6HT
PLXNA1
Q9UIW2
AYKRKSRDADRTLKR
QARRQRLRSKLEQVV
624

HR7225A-1259-1890-TEV
PLXNA2
O75051
AYKRKSRENDLTLKR
RQRLAYKVEQLINAM
632

HR8315A-1241-1867-TEV
PLXNA3
P51805
AYKRKTQDADRTLKR
KHKLRQKLEQIISLV
627

HR7815A-1736-1862-Av6HT
PLXNB1
O43157
DNRLLREDVEYRPLT
ALVPCLTKHVLRENQ
127

HR7815A-1736-1862-TEV
PLXNB1
O43157
DNRLLREDVEYRPLT
ALVPCLTKHVLRENQ
127

HR8081A-1224-1827-NHT
PLXNB2
O15031
SQQAEREYEKIKSQL
PAAQKMQLAFRLQQI
604

HR8081A-1224-1827-TEV
PLXNB2
O15031
SQQAEREYEKIKSQL
PAAQKMQLAFRLQQI
604

HR6985A-1280-1902-TEV
PLXNB3
Q9ULL4
GVGMGAAVLIAAVLL
LYNHIHRYYDQIISA
623

HR7941A-1198-1305-TEV
PLXNC1
O60486
TVALNVVFEKIPENE
HYEISNGSTIKVFKK
108

HR8405A-1553-1678-NHT
PLXND1
Q9Y4D7
AKPRNLNVSFQGCGM
RVKDLDTEKYFHLVL
126

HR6974A-571-650-TEV
PMS1
P54277
IKKPMSASALFVQDH
KRAIEQESQMSLKDG
80

HR6952A-34-103-NHT
POGK
Q9P215
QKVRICSEGGWVPAL
PFPKPDMITRLEGEE
70

HR7570A-37-117-NHT
POLE4
Q9NR33
RLSRLPLARVKALVK
IEAVDEFAFLEGTLD
81

HR7808-15
POLR2L
P62875
MIIPVRCFTCGKIVG
DLIEKLLNYAPLEK*
68

HR8543A-1-154-Av6HT
POTEKP
Q9BYX7
DDDTAVLVIDNGSGM
LSLYTSGRTTGIVMD
153

HR4466B-129-273-TEV
POU1F1
P28069
IRELEKFANEFKVRR
RVWFCNRRQREKRVK
145

HR7752A-297-359-TEV
POU2F2
P09086
EKSFLANQKPTSEEI
APMLPSPGKPASYSP
63

HR7822A-187-257-TEV
POU2F3
Q9UKI9
DLEELEKFAKTFKQR
CKLKPLLEKWLNDAE
71

HR7177A-250-322-Av6HT
POU3F1
Q03052
PSSDDLEQFAKQFKQ
KLKPLLNKWLEETDS
73

HR6946A-348-418-15
POU3F2
P20265
MIAAQGRKRKKRTSI
NRRQKEKRMTPPGGT
72

HR6946A-353-407-Av6HT
POU3F2
P20265
RKRKKRTSIEVSVKG
LEKEVVRVWFCNRRQ
55

HR6946A-353-414-15
POU3F2
P20265
MRKRKKRTSIEVSVK
VWFCNRRQKEKRMTP
63

HR6946A-356-432-15
POU3F2
P20265
MKKRTSIEVSVKGAL
TLPGAEDVYGGSRDT
78

HR6946A-361-427-15
POU3F2
P20265
MIEVSVKGALESHFL
TPPGGTLPGAEDVYG
58

HR6946A-377-427-15
POU3F2
P20265
MPKPSAQEITSLADS
TPPGGTLPGAEDVYG
52

HR8066A-320-388-TEV
POU3F3
P20264
DDLEQFAKQFKQRRI
CKLKPLLNKWLEEAD
69

HR8200A-192-260-TEV
POU3F4
P49335
DELEQFAKQFKQRRI
CKLKPLLNKWLEEAD
69

HR7341A-253-330-NHT
POU4F2
Q12837
ADPRDLEAFAERFKQ
KPILQAWLEEAEKSH
78

HR7479A-183-261-NHT
POU4F3
Q15319
DPRELEAFAERFKQR
VLQAWLEEAEAAYRE
79

HR7056A-224-289-TEV
POU5F1
Q01860
ETLVQARKRKRTSIE
RVWFCNRRQKGKRSS
66

HR8237A-224-288-NHT
POU5F1B
Q06416
ETLMQARKRKRTSIE
RVWFCNRRQKGKRSS
65

HR8392A-142-292-TEV
POU6F1
Q14863
INLEEIREFAKNFKI
VRVWFCNRRQTLKNT
151

HR7133A-97-168-15
PPARA
Q07869
MALNIECRICGDKAS
QYCRFHKCLSVGMSH
73

HR7133A-97-168-Av6HT
PPARA
Q07869
ALNIECRICGDKASG
QYCRFHKCLSVGMSH
72

HR7133A-97-168-TEV
PPARA
Q07869
ALNIECRICGDKASG
QYCRFHKCLSVGMSH
72

HR7133A-97-174-15
PPARA
Q07869
MALNIECRICGDKAS
KCLSVGMSHNAIRFG
79

HR7133A-97-174-Av6HT
PPARA
Q07869
ALNIECRICGDKASG
KCLSVGMSHNAIRFG
78

HR7133A-97-174-TEV
PPARA
Q07869
ALNIECRICGDKASG
KCLSVGMSHNAIRFG
78

HR7133A-97-187-15
PPARA
Q07869
MALNIECRICGDKAS
FGRMPRSEKAKLKAE
92

HR7133A-97-187-Av6HT
PPARA
Q07869
ALNIECRICGDKASG
FGRMPRSEKAKLKAE
91

HR7133A-97-187-TEV
PPARA
Q07869
ALNIECRICGDKASG
FGRMPRSEKAKLKAE
91

HR7133B-182-468-15
PPARA
Q07869
MAKLKAEILTGEHDI
AALHPLLQEIYRDMY
288

HR7133B-182-468-Av6HT
PPARA
Q07869
AKLKAEILTCEHDIE
AALHPLLQEIYRDMY
287

HR7133B-182-468-TEV
PPARA
Q07869
AKLKAEILTCEHDIE
AALHPLLQEIYRDMY
287

HR7133C-192-468-15
PPARA
Q07869
MEHDIEDSETADLKS
AALHPLLQEIYRDMY
278

HR7133C-192-468-Av6HT
PPARA
Q07869
EHDIEDSETADLKSL
AALHPLLQEIYRDMY
277

HR7133C-192-468-TEV
PPARA
Q07869
EHDIEDSETADLKSL
AALHPLLQEIYRDMY
277

HR8028A-67-146-15
PPARD
Q03181
MCGSLNMECRVCGDK
KCLALGMSHNAIRFG
81

HR8028A-67-146-Av6HT
PPARD
Q03181
CGSLNMECRVCGDKA
KCLALGMSHNAIRFG
80

HR8028A-67-146-TEV
PPARD
Q03181
CGSLNMECRVCGDKA
KCLALGMSHNAIRFG
80

HR8028A-67-156-15
PPARD
Q03181
MCGSLNMECRVCGDK
AIRFGRMPEAEKRKL
91

HR8028A-67-156-Av6HT
PPARD
Q03181
CGSLNMECRVCGDKA
AIRFGRMPEAEKRKL
90

HR8028A-67-156-TEV
PPARD
Q03181
CGSLNMECRVCGDKA
AIRFGRMPEAEKRKL
90

HR8028A-73-146-15
PPARD
Q03181
MECRVCGDKASGFHY
KCLALGMSHNAIRFG
75

HR8028A-73-146-Av6HT
PPARD
Q03181
ECRVCGDKASGFHYG
KCLALGMSHNAIRFG
74

HR8028A-73-146-TEV
PPARD
Q03181
ECRVCGDKASGFHYG
KCLALGMSHNAIRFG
74

HR8028A-73-156-15
PPARD
Q03181
MECRVCGDKASGFHY
AIRFGRMPEAEKRKL
85

HR8028A-73-156-Av6HT
PPARD
Q03181
ECRVCGDKASGFHYG
AIRFGRMPEAEKRKL
84

HR8028A-73-156-TEV
PPARD
Q03181
ECRVCGDKASGFHYG
AIRFGRMPEAEKRKL
84

HR80288-163-441-15
PPARD
Q03181
MNEGSQYNPQVADLK
TSLHPLLQEIYKDMY
280

HR8028B-163-441-Av6HT
PPARD
Q03181
NEGSQYNPQVADLKA
TSLHPLLQEIYKDMY
279

HR8028B-163-441-TEV
PPARD
Q03181
NEGSQYNPQVADLKA
TSLHPLLQEIYKDMY
279

HR4464B-222-504-TEV
PPARG
P37231
LAEISSDIDQLNPES
DMSLHPLLQEIYKDL
283

HR7373A-58-198-NHT
PPP1R10
Q96QC0
RSPEILVKFIDVGGY
AEEAPEKKREKPKSL
141

HR7854A-111-311-Av6HT
PPP2R3B
Q9Y5P8
TRKEEPLPPATSQSI
LLEEEADINQLTEFF
201

HR6538A-2-187-TEV
PRDM1
O75626
LDICLEKRVGTTLAA
LAACQNGMNIYFYTI
186

HR7699A-188-339-TEV
PRDM10
Q9NQV6
KHGPLHPIPNRPVLT
YAASYAEFVNQKIHD
152

HR6506A-60-229-TEV
PRDM12
Q9H4Q4
KTAFTAEVLAQSFSG
VPGLEEDQKKNKHED
170

HR7923A-243-372-Av6HT
PRDM14
Q9GZV8
DKDSLQLPEGLCLMQ
QNQELLVWYGDCYEK
130

HR8160A-72-214-Av6HT
PRDM16
Q9HAZ2
VYIPEDIPIPADFEL
IEPGEELLVHVKEGV
143

HR4804B-1144-1216-14
PRDM2
Q13029
MLSIKDLTKHLSIHA
FLCNLQQHQRDLHPD
74

HR4804B-1144-1221-14
PRDM2
Q13029
MLSIKDLTKHLSIHA
QQHQRDLHPDKVCTH
79

HR4804B-1144-1230-14
PRDM2
Q13029
MLSIKDLTKHLSIHA
DKVCTHHEFESGTLR
88

HR4804B-1158-1216-14
PRDM2
Q13029
MEEWPFKCEFCVQLF
FLCNLQQHQRDLHPD
60

HR4804B-1158-1221-14
PRDM2
Q13029
MEEWPFKCEFCVQLF
QQHQRDLHPDKVCTH
65

HR4804B-1158-1230-14
PRDM2
Q13029
MEEWPFKCEFCVQLF
DKVCTHHEFESGTLR
74

HR4804C-342-415-14
PRDM2
Q13029
MQIPRTKEEANGDVF
TQINRRRHERRHEAG
75

HR4804C-356-417-14
PRDM2
Q13029
METFMFPCQHCERKF
INRRRHERRHEAGLK
63

HR4804C-360-422-14
PRDM2
Q13029
MFPCQHCERKFTTKQ
HERRHEAGLKRKPSQ
64

HR4804C-367-417-14
PRDM2
Q13029
MRKFTTKQGLERHMH
INRRRHERRHEAGLK
52

HR4804D-2-148-TEV
PRDM2
Q13029
NQNTTEPVAATETLA
EELLVWYNGEDNPEI
147

HR6504A-390-540-TEV
PRDM4
Q9UKN5
EHGPVTFVPDTPIES
FYYSRDYAQQIGVPE
151

HR7347A-1-135-NHT
PRDM5
Q9NQX1
LGMYVPDRFSLKSSR
IGYLDSDMEAEEEEQ
134

HR8295A-234-370-Av6HT
PRDM6
Q9NQX0
PPELPEWLRDLPREV
RGTELLVWYNDSYTS
137

HR7077A-196-395-NHT
PRDM7
Q9NQW5
EPQDDDYLYCEMCQN
VNCWSGMGMSMARNW
200

HR8098A-623-689-Av6HT
PRDM8
Q9NQV8
AQNWCAKCNASFRMT
FRERHHLSRHMTSHN
67

HR8069A-197-382-Av6HT
PRDM9
Q9NQV7
PQDDDYLYCEMCQNF
KWGSKWKKELMAGRE
186

HR7506-125-390-Av6HT
PREB
Q9HCU5
EKKCGAETQHEGLEL
SRCQLHLLPSRRSVP
266

HR7506A-125-312-Av6HT
PREB
Q9HCU5
EKKCGAETQHEGLEL
CGHEVVSCLDVSESG
188

HR7506A-133-315-Av6HT
PREB
Q9HCU5
QHEGLELRVENLQAV
EVVSCLDVSESGTFL
183

HR7506A-155-312-15
PREB
Q9HCU5
MPLQKVVCFNHDNTL
CGHEVVSCLDVSESG
159

HR8329A-190-376-Av6HT
PREX2
Q70Z35
KHSDYAAVMEALQAM
RRKGLKLGMEQDTWV
187

HR8329B-674-751-Av6HT
PREX2
Q70Z35
PRETVKIPDSADGLG
AHVTACRKYRRPTKQ
78

HR8329B-674-760-Av6HT
PREX2
Q70Z35
PRETVKIPDSADGLG
RRPTKQDSIQWVYNS
87

HR2833A-1-98-NHT
PRKRIR
O43422
GQLKFNTSEEHHADM
ERYENGRKRLKAYLR
97

HR3353-149-736-14
PRKRIR
O43422
MDEDILPLTLEEKEN
LLNINFDIKHDLDLM
589

HR3353-154-731-14
PRKRIR
O43422
MPLTLEEKENKEYLK
SSNLALLNINFDIKH
579

HR4564B-74-136-14
PROP1
O75360
MTTFSPVQLEQLESA
AKQRKQERSLLQPLA
64

HR4660B-14
PROX1
Q92786
MAMQEGLSPNHLKKA
EIFKSPNCLQELLHE
164

HR4660B-15
PROX1
Q92786
MAMQEGLSPNHLKKA
EIFKSPNCLQELLHE
164

HR4660C-546-737-14
PROX1
Q92786
MTAEGLSLSLIKSEC
EIFKSPNCLQELLHE
193

HR4660C-550-737-14
PROX1
Q92786
MLSISLIKSECGDLQ
EIFKSPNCLQELLHE
189

HR4660C-566-737-14
PROX1
Q92786
MSEISPYSGSAMQEG
EIFKSPNCLQELLHE
173

HR4660C-572-737-14
PROX1
Q92786
MSGSAMQEGLSPNHL
EIFKSPNCLQELLHE
167

HR4660C-577-737-14
PROX1
Q92786
MQEGLSPNHLKKAKL
EIFKSPNCLQELLHE
162

HR8100A-409-592-Av6HT
PROX2
Q3B8N5
LPLLPSVKMEQRGLH
DSDIPEIFKSSSYPQ
184

HR6440-1-237-14
PRRX1
P54821
MTSSYGHVLERQPAL
SIANLRLKAKEYSLQ
237

HR6440-14
PRRX1
P54821
MTSSYGHVLERQPAL
AKEYSLQRNQVPTVN
245

HR6440-22-245-14
PRRX1
P54821
PGNLDTLQAKKNFSV
AKEYSLQRNQVPTVN
224

HR6440-27-245-14
PRRX1
P54821
TLQAKKNFSVSHLLD
AKEYSLQRNQVPTVN
219

HR7233A-95-168-Av6HT
PRRX2
Q99811
GSAAKRKKKQRRNRT
NRRAKFRRNERAMLA
74

HR7750A-100-341-Av6HT
PSMD11
O00231
EAATGQEVELCLECI
YDNLLEQNLIRVIEP
242

HR7208-1-335-TEV
PSMD12
O00232
ADGGSERADGRIVKM
VEDYGMELRKGSLES
334

HR7208-11-335-TEV
PSMD12
O00232
GRIVKMEVDYSATVD
VEDYGMELRKGSLES
325

HR7208-TEV
PSMD12
O00232
ADGGSERADGRIVKM
THLIAKEEMIHNLQ*
456

HR7208A-338-425-15
PSMD12
O00232
MTDVFGSTEEGEKRW
GIINFQRPKDPNNLL
89

HR7208A-338-456-15
PSMD12
O00232
MTDVFGSTEEGEKRW
TTHLIAKEEMIHNLQ
120

HR7208A-343-420-15
PSMD12
O00232
MSTEEGEKRWKDLKN
VDRLAGIINFQRPKD
79

HR7208A-343-456-15
PSMD12
O00232
MSTEEGEKRWKDLKN
TTHLIAKEEMIHNLQ
115

HR7208A-371-456-15
PSMD12
O00232
MTRITMKRMAQLLDL
TTHLIAKEEMIHNLQ
87

HR7208B-300-417-TEV
PSMD12
O00232
PKYKDLLKLFTTMEL
FAKVDRLAGIINFQR
118

HR7208C-300-456-TEV
PSMD12
O00232
PKYKDLLKLFTTMEL
TTHLIAKEEMIHNLQ
157

HR5110A-437-891-Av6HT
Q6ZU11
Q6ZU11
LNKDQATALIQIAQM
HCEGREDGLQHANQY
455

HR7981A-147-199-TEV
RABGEF1
Q9UJ41
KTFHKTGQEIYKQTK
FYHNVAERMQTRGKV
53

HR8212A-1-114-NHT
RAD51
Q06609
AMQMQLEANADTSVE
IQITTGSKELDKLLQ
113

HR7353A-268-383-TEV
RAG1
P15918
NCSKIHLSTKLLAVD
LEKYNHHISSHKESK
116

HR7829A-213-923-TEV
RAPGEF3
O95398
PDALLTVALRKPPGQ
DNQRELSRLSRELEP
711

HR7829B-33-923-TEV
RAPGEF3
O95398
DVVPEGTLLNMVLRR
DNQRELSRLSRELEP
891

HR8365C-81-160-NHT
RARA
P10276
LPRIYKPCFVCQDKS
QKCFEVGMSKESVRN
80

HR8365C-81-160-TEV
RARA
P10276
LPRIYKPCFVCQDKS
QKCFEVGMSKESVRN
80

HR6970C-82-160-TEV
RARB
P10826
FVCQDKSSGYHYGVS
MSKESVRNDRNKKKK
79

HR7515A-85-154-15
RARG
P13631
MRVYKPCFVCNDKSS
NRCQYCRLQKCFEVG
71

HR7515A-85-154-Av6HT
RARG
P13631
RVYKPCFVCNDKSSG
NRCQYCRLQKCFEVG
70

HR7515A-85-154-TEV
RARG
P13631
RVYKPCFVCNDKSSG
NRCQYCRLQKCFEVG
70

HR7515A-85-166-15
RARG
P13631
MRVYKPCFVCNDKSS
EVGMSKEAVRNDRNK
83

HR7515A-85-166-Av6HT
RARG
P13631
RVYKPCFVCNDKSSG
EVGMSKEAVRNDRNK
82

HR7515A-85-166-TEV
RARG
P13631
RVYKPCFVCNDKSSG
EVGMSKEAVRNDRNK
82

HR7515A-97-166-15
RARG
P13631
MSSGYHYGVSSCEGC
EVGMSKEAVRNDRNK
71

HR7515A-97-166-Av6HT
RARG
P13631
SSGYHYGVSSCEGCK
EVGMSKEAVRNDRNK
70

HR7515A-97-166-TEV
RARG
P13631
SSGYHYGVSSCEGCK
EVGMSKEAVRNDRNK
70

HR7515B-178-423-15
RARG
P13631
MDSYELSPQLEELIT
PPLIREMLENPEMFE
247

HR7515B-178-423-Av6HT
RARG
P13631
DSYELSPQLEELITK
PPLIREMLENPEMFE
246

HR7515B-178-423-TEV
RARG
P13631
DSYELSPQLEELITK
PPLIREMLENPEMFE
246

HR7515C-183-417-15
RARG
P13631
MSPQLEELITKVSKA
EIPGPMPPLIREMLE
236

HR7515C-183-417-Av6HT
RARG
P13631
SPQLEELITKVSKAH
EIPGPMPPLIREMLE
235

HR7515C-183-417-TEV
RARG
P13631
SPQLEELITKVSKAH
EIPGPMPPLIREMLE
235

HR7515D-84-169-15
RARG
P13631
MPRVYKPCFVCNDKS
MSKEAVRNDRNKKKK
87

HR7515D-84-169-Av6HT
RARG
P13631
PRVYKPCFVCNDKSS
MSKEAVRNDRNKKKK
86

HR7515D-84-169-TEV
RARG
P13631
PRVYKPCFVCNDKSS
MSKEAVRNDRNKKKK
86

HR8219A-137-208-Av6HT
RAX
Q9Y2V3
RRNRTTFTTYQLHEL
QEKLEVSSMKLQDSP
72

HR8168A-24-86-Av6HT
RAX2
Q96IS3
KKKHRRNRTTFTTYQ
QVWFQNRRAKWRRQE
63

HR7540-167-714-15
RBAK
Q9NYW8
MECGKTYHGEKMCEF
IHRRGNMNVLDVENL
549

HR7540-171-714-15
RBAK
Q9NYW8
MTYHGEKMCEFNQNG
IHRRGNMNVLDVENL
545

HR7540-183-714-15
RBAK
Q9NYW8
MNGDTYSHNEENILQ
IHRRGNMNVLDVENL
533

HR7540-188-714-15
RBAK
Q9NYW8
MSHNEENILQKISIL
IHRRGNMNVLDVENL
528

HR7540-7-562-15
RBAK
Q9NYW8
MPVSFKDVAVDFTQE
FNELSYYTEHYRSHS
557

HR7540A-397-562-TEV
RBAK
Q9NYW8
GEKLYKCNECGKSYY
FNELSYYTEHYRSHS
166

HR7540A-397-591-TEV
RBAK
Q9NYW8
GEKLYKCNECGKSYY
SHNSSLFRHQRVHTG
195

HR7540A-428-562-TEV
RBAK
Q9NYW8
PYQCSECGKFFSRVS
FNELSYYTEHYRSHS
135

HR7540A-428-591-TEV
RBAK
Q9NYW8
PYQCSECGKFFSRVS
SHNSSLFRHQRVHTG
164

HR7540B-1-64-Av6HT
RBAK
Q9NYW8
NTLQGPVSFKDVAVD
DTTKPNVIIKLEQGE
63

HR7540C-633-701-Av6HT
RBAK
Q9NYW8
SRMSNLTVHYRSHSG
KFHHRSAFNSHQRIH
69

HR7540C-649-701-Av6HT
RBAK
Q9NYW8
KPYECNECGKVFSQK
KFHHRSAFNSHQRIH
53

HR7540C-653-701-Av6HT
RBAK
Q9NYW8
CNECGKVFSQKSYLT
KFHHRSAFNSHQRIH
49

HR8531A-503-605-Av6HT
RBM20
Q5T481
LASVGTTFAQRKGAG
SKRYKELQLKKPGKA
103

HR7548A-227-304-TEV
RBM22
Q9NW64
EDKTITTLYVGGLGD
KLIVNGRRLNVKWGR
78

HR7417A-596-679-NHT
RBM27
Q9P2N5
QYTNTKLEVKKIPQE
RFIRVLWHRENNEQP
84

HR7740A-184-325-NHT
RBM5
P52756
DWLCNKCCLNNFRKR
DFAKSARKDLVLSDG
142

HR6987A-23-453-TEV
RBPJ
Q06330
GERPPPKRLTREAMR
SLTFTYTPEPGPRPH
431

HR7414A-356-477-NHT
RBPJL
Q9UBG7
SSCWTIIGTESVEFS
DGLFYPSAFSFTYTP
122

HR8038A-1-79-Av6HT
RC3H2
Q9HBD1
PVQAAQWTEFLSCPI
PVNFALLQLVGAQVP
78

HR7631A-308-440-TEV
RCOR1
Q9UKL0
RKPPKGMFLSQEDVE
RRFNIDEVLQEWEAE
133

HR7631B-158-237-Av6HT
RCOR1
Q9UKL0
GYNMEQALGMLFWHK
IASLVKFYYSWKKTR
80

HR7631B-158-247-Av6HT
RCOR1
Q9UKL0
GYNMEQALGMLFWHK
WKKTRTKTSVMDRHA
90

HR7631B-172-237-Av6HT
RCOR1
Q9UKL0
KHNIEKSLADLPNFT
IASLVKFYYSWKKTR
66

HR7631B-172-247-Av6HT
RCOR1
Q9UKL0
KHNIEKSLADLPNFT
WKKTRTKTSVMDRHA
76

HR7640A-292-387-NHT
RCOR2
Q8IZ40
ISLKRQVQSMKQTNS
YRRRFNLEEVLQEWE
96

HR2844A-14
REL
Q04864
EKDTYGNKAKKQKTT
NEQLSDSFPYEFFQV
337

HR2844B-14
REL
Q04864
EKDTYGNKAKKQKTT
NSQGIPPFLRIPVGN
171

HR2844C-14
REL
Q04864
DLNASNACIYNNADD
NEQLSDSFPYEFFQV
166

HR2845-14
RELA
Q04206
MDELFPLIFPAEPAQ
IADMDFSALLSQISS
551

HR2845B-14
RELA
Q04206
TDDRHRIEEKRKRTY
QFDDEDLGALLGNST
167

HR2845C-14
RELA
Q04206
DPAVFTDLASVDNSE
IADMDFSALLSQISS
93

HR2845D-191-291-Av6HT
RELA
Q04206
TAELKICRVNRNSGS
DRELSEPMEFQYLPD
101

HR2845D-191-291-TEV
RELA
Q04206
TAELKICRVNRNSGS
DRELSEPMEFQYLPD
101

HR2846-40-579-15
RELB
Q01201
MLSSLSLAVSRSTDE
AAFGGGLLSPGPEAT
541

HR2846B-14
RELB
Q01201
DHDSYGVDKKRKRGM
AAFGGGLLSPGPEAT
179

HR6006B-21
RERE
Q9P2R6
STQGEIRVGPSHQAK
LITFYYYWKKTPEAA
165

HR6006C-21
RERE
Q9P2R6
STQGEIRVGPSHQAK
RLVKKPVPKLIEKCW
116

HR6006D-21
RERE
Q9P2R6
STQGEIRVGPSHQAK
DLLMYLRAARSMAAF
60

HR6006E-21
RERE
Q9P2R6
VTQHEELVWMPGVND
ETGELITFYYYWKKT
132

HR6006F-21
RERE
Q9P2R6
VTQHEELVWMPGVND
RLVKKPVPKLIEKCW
87

HR6006H-21
RERE
Q9P2R6
QGEIRVGPSHQAKLP
ETGELITFYYYWKKT
159

HR6969A-342-413-NHT
REST
Q13127
SNQHEVTRHARQVHN
SKKCNLQYHFKSKHP
72

HR8119A-438-513-TEV
RFX1
P22670
TVQWLLDNYETAEGV
RGNSKYHYYGLRIKA
76

HR7754A-200-273-TEV
RFX2
P48378
LQWLLDNYETAEGVS
TRGNSKYHYYGIRLK
74

HR7471A-184-257-TEV
RFX3
P48380
LQWLLDNYETAEGVS
TRGNSKYHYYGIRVK
74

HR8007A-101-167-15
RFX5
P48382
MEEHTDTCLPKQSVY
GRGQSKYCYSGIRRK
68

HR8007A-76-173-15
RFX5
P48382
MDKSSEPSTLSNEEY
YCYSGIRRKTLVSMP
99

HR8007A-81-167-15
RFX5
P48382
MPSTLSNEEYMYAYR
GRGQSKYCYSGIRRK
88

HR7289A-107-205-NHT
RFX6
Q8HWS3
KKTITQIVKDKKKQT
HYYGIGIKESSAYYH
99

HR7790-68-260-TEV
RFXANK
O14593
KHSTTLTNRQRGNEV
ILKLFQSNLVPADPE
193

HR7790-79-260-TEV
RFXANK
O14593
GNEVSALPATLDSLS
ILKLFQSNLVPADPE
182

HR7790A-101-248-15
RFXANK
O14593
MGELDQLKEHLRKGD
GYRKVQQVIENHILK
149

HR7790A-101-260-15
RFXANK
O14593
MGELDQLKEHLRKGD
ILKLFQSNLVPADPE
161

HR7790A-79-248-15
RFXANK
O14593
MGNEVSALPATLDSL
GYRKVQQVIENHILK
171

HR7790A-86-251-15
RFXANK
O14593
MPATLDSLSIHQLAA
KVQQVIENHILKLFQ
167

HR7790A-91-248-15
RFXANK
O14593
MSLSIHQLAAQGELD
GYRKVQQVIENHILK
159

HR7790A-91-260-15
RFXANK
O14593
MSLSIHQLAAQGELD
ILKLFQSNLVPADPE
171

HR7361A-325-470-TEV
RGS6
P49758
PSQQRVKRWGFSFDE
KGKSLAGKRLTGLMQ
146

HR6895A-323-449-TEV
RGS7
P49802
SQQRVKRWGFGMDEA
YPRFIRSSAYQELLQ
127

HR6935A-279-424-TEV
RGS9
O75916
DLNAKLVEIPTKMRV
YKDMLAKAIEPQETT
146

HR7291A-130-236-NHT
RHOXF2
Q9BQY4
PGNAQQPNVHAFTPL
PLFISGMRDDYFWDH
107

HR7532A-130-236-NHT
RHOXF2B
P0C7M4
PGNAQQPNVHAFTPL
PLFISGMRDDYFWDH
107

HR7189A-91-307-Av6HT
RIOK2
Q9BVS4
RQVVESVGNQMGVGK
EDTLDVEVSASGYTK
217

HR7201A-769-825-Av6HT
RLF
Q13129
LRYKCELNGCNIVFS
FYYSKIEYQNHLSMH
57

HR7201A-769-837-NHT
RLF
Q13129
LRYKCELNGCNIVFS
SMHNVENSNGDIKKS
69

HR7201B-707-825-Av6HT
RLF
Q13129
LDMKNRREKCTYCRR
FYYSKIEYQNHLSMH
119

HR7201B-707-837-Av6HT
RLF
Q13129
LDMKNRREKCTYCRR
SMHNVENSNGDIKKS
131

HR7201B-716-825-Av6HT
RLF
Q13129
CTYCRRHFMSAFHLR
FYYSKIEYQNHLSMH
110

HR7201B-716-837-Av6HT
RLF
Q13129
CTYCRRHFMSAFHLR
SMHNVENSNGDIKKS
122

HR7201C-707-770-Av6HT
RLF
Q13129
LDMKNRREKCTYCRR
VNELLNHKQKHDDLR
64

HR7201C-725-770-Av6HT
RLF
Q13129
SAFHLREHEQVHCGP
VNELLNHKQKHDDLR
46

HR7461A-26-161-TEV
RNASE2
P10153
HVKPPQFTWAQWFET
PPQYPVVPVHLDRII
136

HR7865A-252-319-TEV
RNF113A
O15541
GSDDEEIPFKCFICR
GVFNPAKELIAKLEK
68

HR7107A-246-319-TEV
RNF113B
Q8IZP6
GSEEEEIPFRCFICR
KELMAKLQKLQAAEG
74

HR7482A-1-89-NHT
RNF114
Q9Y508
AAQQRDCGGAAQLAG
VRAVELERQIESTET
88

HR7645A-17-100-NHT
RNF125
Q96EQ8
ATARALERRRDPELP
ATDVAKRMKSEYKNC
84

HR4563B-87-210-14
RORA
P35398
MKEDKEVQTGYMNAQ
HRMQQQQRDHQQQPG
125

HR4563B-92-174-14
RORA
P35398
MVQTGYMNAQIEIIP
HCRLQKCLAVGMSRD
84

HR4563B-92-193-14
RORA
P35398
MVQTGYMNAQIEIIP
GRMSKKQRDSLYAEV
103

HR4563B-93-210-14
RORA
P35398
MQTGYMNAQIEIIPC
HRMQQQQRDHQQQPG
119

HR4563B-98-174-14
RORA
P35398
MNAQIEIIPCKICGD
HCRLQKCLAVGMSRD
78

HR4563B-98-193-14
RORA
P35398
MNAQIEIIPCKICGD
GRMSKKQRDSLYAEV
97

HR7194B-260-507-TEV
RORC
P51449
PEAPYASLTEIEHLV
VVQAAFPPLYKELFS
248

HR7255A-172-270-Av6HT
RPA2
P15927
ANSQPSAGRAPISNP
YSTVDDDHFKSTDAE
99

HR7255A-172-270-TEV
RPA2
P15927
ANSQPSAGRAPISNP
YSTVDDDHFKSTDAE
99

HR7006A-95-145-NHT
RREB1
Q92766
ADHSCSICGKSLSSA
GQSFTTNGNMHRHMK
51

HR4447C-46-185-Av6HT
RUNX1
Q01196
MSGDRSMVEVLADHP
DGPREPRRHRQKLDD
141

HR4447C-46-185-TEV
RUNX1
Q01196
SGDRSMVEVLADHPG
DGPREPRRHRQKLDD
140

HR4568B-112-233-TEV
RUNX2
Q13950
ELVRTDSPNFLCSVL
VTVDGPREPRRHRQK
122

HR7324A-53-189-TEV
RUNX3
Q13761
QAAVGPGGRARPEVR
TQVATYHRAIKVTVD
137

HR4643B-135-200-TEV
RXRA
P19793
CAICGDRSSGKHYGV
RCQYCRYQKCLAMGM
66

HR8407C-205-270-NHT
RXRB
P28702
CAICGDRSSGKHYGV
RCQYCRYQKCLATGM
66

HR8407C-205-270-TEV
RXRB
P28702
CAICGDRSSGKHYGV
RCQYCRYQKCLATGM
66

HR47518-139-204-TEV
RXRG
P48443
CAICGDRSSGKHYGV
RCQYCRYQKCLVMGM
66

HR7653A-909-977-NHT
SALL2
Q9Y467
SRKACEVCGQAFPSQ
HHQVQPFAPHGPQNI
69

HR7433A-975-1045-NHT
SALL3
Q9BXA9
PSTVCGVCGKPFACK
ELPSQLFDPNFALGP
71

HR6875A-376-433-Av6HT
SALL4
Q9UJQ4
MEAALYKHKCKYCSK
FTTKGNLKVHFHRHP
59

HR6875A-376-433-NHT
SALL4
Q9UJQ4
EAALYKHKCKYCSKV
FTTKGNLKVHFHRHP
58

HR4435B-174-250-14
SATB1
Q01826
MPKLEDLPPEQWSHT
FGRWYKHFKKTKDMM
78

HR4435B-174-254-14
SATB1
Q01826
MPKLEDLPPEQWSHT
YKHFKKTKDMMVEMD
82

HR4435B-179-244-14
SATB1
Q01826
MLPPEQWSHTTVRNA
AAKCQEFGRWYKHFK
67

HR4435B-179-250-14
SATB1
Q01826
MLPPEQWSHTTVRNA
FGRWYKHFKKTKDMM
73

HR4435C-368-452-TEV
SATB1
Q01826
NTEVSSEIYQWVRDE
AERDRIYQDERERSL
85

HR4435D-53-254-15
SATB1
Q01826
MQGVPLKHSGHLMKT
YKHFKKTKDMMVEMD
203

HR4435D-56-250-15
SATB1
Q01826
MPLKHSGHLMKTNLR
FGRWYKHFKKTKDMM
196

HR4435E-53-178-15
SATB1
Q01826
MQGVPLKHSGHLMKT
VTLKIQLHSCPKLED
127

HR4435E-56-175-15
SATB1
Q01826
MPLKHSGHLMKTNLR
YHVVTLKIQLHSCPK
121

HR7571A-350-437-NHT
SATB2
Q9UPW6
KPEPTNSSVEVSPDI
NLPEVERDRIYQDER
88

HR7571B-610-674-TEV
SATB2
Q9UPW6
SCAKKPRSRTKISLE
IKFFQNQRYHVKHHG
65

HR5092A-90-156-Av6HT
SCAPER
Q9BY12
RHPRKIDLRARYWAF
DFKALIDWIQLQEKL
67

HR8394A-256-325-Av6HT
SCRT1
Q9BWW7
AFSRPWLLQGHMRSH
KSFALKSYLNKHYES
70

HR7196A-158-206-NHT
SCRT2
Q9NQ03
ACAECCKTYATSSNL
GKAYVSMPALAMHLL
51

HR3583D-653-871-15
SETDB1
Q15047
MLFLEMFCLDPYVLV
LDHIESVENFKEGYE
220

HR3583D-658-867-15
SETDB1
Q15047
MFCLDPYVLVDRKFQ
YFANLDHIESVENFK
211

HR3583E-555-676-15
SETDB1
Q15047
MLERAPAEPSYRAPM
PYVLVDRKFQPYKPF
123

HR3583E-584-681-15
SETDB1
Q15047
MSRVRPMRNEQYRGK
DRKFQPYKPFYYILD
99

HR3583E-590-676-15
SETDB1
Q15047
MRNEQYRGKNPLLVP
PYVLVDRKFQPYKPF
88

HR8073A-102-182-Av6HT
SHOX
Q15266
EDVKSEDEDGQTKLK
RRAKCRKQENQMHKG
81

HR6933A-647-727-Av6HT
SHPRH
Q149N8
NTMSPFNTSDYRFEC
VSTRATLIISPSSIC
81

HR6933A-647-739-NHT
SHPRH
Q149N8
NTMSPFNTSDYRFEC
SICHQWVDEINRHVR
93

HR6933A-654-727-Av6HT
SHPRH
Q149N8
TSDYRFECICGELDQ
VSTRATLIISPSSIC
74

HR6933A-654-739-Av6HT
SHPRH
Q149N8
TSDYRFECICGELDQ
SICHQWVDEINRHVR
86

HR6933B-437-502-Av6HT
SHPRH
Q149N8
VQCPPTRVMILTAVK
KCLIFEGLVKQIKGH
66

HR6933B-437-512-Av6HT
SHPRH
Q149N8
VQCPPTRVMILTAVK
QIKGHGFSGTFTLGK
76

HR6933C-1495-1636-Av6HT
SHPRH
Q149N8
KANQEEDIPVKGSHS
GQTKPTIVHRFLIKA
142

HR6933C-1495-1646-Av6HT
SHPRH
Q149N8
KANQEEDIPVKGSHS
FLIKATIEERMQAML
152

HR6933C-1495-1659-Av6HT
SHPRH
Q149N8
KANQEEDIPVKGSHS
MLKTAERSHTNSSAK
165

HR7129A-227-345-NHT
SIM1
P81133
LHSNMFMFRASLDMK
VLTDTEYKGLQLSLD
119

HR8357A-72-194-Av6HT
SIM2
Q14190
PLDGVAKELGSHLLQ
YKVIHCSGYLKIRQY
123

HR7143A-205-281-Av6HT
SIX3
Q95343
DGEQKTHCFKERTRS
KNRLQHQAIGPSGMR
77

HR7095A-206-294-Av6HT
SIX4
Q9UIU6
DKYRLRRKFPLPRTI
NPSETQSKSESDGNP
89

HR8072A-125-195-Av6HT
SIX6
O95475
IWDGEQKTHCFKERT
QRDRAAAAKNRLQQQ
71

HR4810B-218-313-TEV
SKI
P12755
VRVYHECFGKCKGLL
RLGRCLDDVKEKFDY
96

HR8491B-28-132-Av6HT
SKOR2
Q2VWA4
QPRPGHANLKPNQVG
ITKREAERLCKSFLG
105

HR8491C-141-237-Av6HT
SKOR2
Q2VWA4
DNFAFDVSHECAWGC
ELVFAWEDVKAMFNG
97

HR8491C-141-244-Av6HT
SKOR2
Q2VWA4
DNFAFDVSHECAWGC
DVKAMFNGGSRKRAL
104

HR8491D-43-132-Av6HT
SKOR2
Q2VWA4
QVILYGIPIVSLVID
ITKREAERLCKSFLG
90

HR7664A-124-217-TEV
SLC30A9
Q6PML9
KYTQNNFITGVRAIN
ERLFRNQKILREYRD
94

HR8337A-9-132-TEV
SMAD1
Q15797
FTSPAVKRLLGWKQG
KEVCINPYHYKRVES
124

HR8337B-248-465-TEV
SMAD1
Q15797
APPLPSEINRGDVQA
LTQMGSPHNPISSVS
218

HR4670B-55-191-14
SMAD2
Q15796
MTGRLDELEKAITTQ
PVLVPRHTEILTELP
138

HR4670B-55-196-14
SMAD2
Q15796
MTGRLDELEKAITTQ
RHTEILTELPPLDDY
143

HR4670B-55-202-14
SMAD2
Q15796
MTGRLDELEKAITTQ
TELPPLDDYTHSIPE
149

HR4670B-55-202-Av6HT
SMAD2
Q15796
TGRLDELEKAITTQN
TELPPLDDYTHSIPE
148

HR4670B-55-202-TEV
SMAD2
Q15796
TGRLDELEKAITTQN
TELPPLDDYTHSIPE
148

HR4670B-6-173-14
SMAD2
Q15796
MPFTPPVVKRLLGWK
EVCVNPYHYQRVETP
169

HR4670C-101-173-14
SMAD2
Q15796
MLYSFSEQTRSLDGR
EVCVNPYHYQRVETP
74

HR4670C-106-173-14
SMAD2
Q15796
MEQTRSLDGRLQVSH
EVCVNPYHYQRVETP
69

HR4670D-261-456-Av6HT
SMAD2
Q15796
LDLQPVTYSEPAFWC
LNGPLQWLDKVLTQM
196

HR4503B-1-148-14
SMAD4
Q13485
MDNMSITNTPTSNDA
ERVVSPGIDLSGLTL
148

HR4503B-1-166-14
SMAD4
Q13485
MDNMSITNTPTSNDA
APSSMMVKDEYVHDF
166

HR4503B-10-160-14
SMAD4
Q13485
MPTSNDACLSIVHSL
LTLQSNAPSSMMVKD
152

HR4503B-11-142-14
SMAD4
Q13485
MTSNDACLSIVHSLM
VNPYHYERVVSPGID
133

HR4503C-9-149-14
SMAD4
Q13485
MTPTSNDACLSIVHS
RVVSPGIDLSGLTLQ
142

HR4503D-314-552-Av6HT
SMAD4
Q13485
ISNHPAPEYWCSIAY
EVLHTMPIADPQPLD
239

HR5565A-14
SMAD6
O43541
MRLSPRDEYKPLDLS
TSCPCWLEILLNNPR
217

HR5560A-14
SMAD7
O15105
MVPSSAETGGTNYLA
ISSCPCWLEVIFNSR
199

HR5560A-15
SMAD7
O15105
MVPSSAETGGTNYLA
ISSCPCWLEVIFNSR
199

HR7626A-769-932-TEV
SMARCA1
P28370
VSEPKIPKAPRPPKQ
QIERGEARIQRRISI
164

HR7914A-754-917-TEV
SMARCA5
O60264
VSEPKAPKAPRPPKQ
QIERGEARIQRRISI
164

HR7256A-607-680-TEV
SMARCC1
Q92922
SKKTLAKSKGASAGR
IEDPYLENSDASLGP
74

HR7400B-419-526-Av6HT
SMARCC2
Q8TAQ2
EQTHHIIIPSYAAWF
YQVDAESRPTPMGPP
108

HR7400B-419-538-Av6HT
SMARCC2
Q8TAQ2
EQTHHIIIPSYAAWF
GPPPTSHFHVLADTP
120

HR7400B-421-520-Av6HT
SMARCC2
Q8TAQ2
THHIIIPSYAAWFDY
QWGLINYQVDAESRP
100

HR7400C-421-514-Av6HT
SMARCC2
Q8TAQ2
THHIIIPSYAAWFDY
VHAFLEQWGLINYQV
94

HR7811A-46-134-NHT
SMARCE1
Q969G3
GTNSRVTASSGITIP
EAEKIEYNESMKAYH
89

HR7811A-46-146-Av6HT
SMARCE1
Q969G3
GTNSRVTASSGITIP
AYHNSPAYLAYINAK
101

HR7520-1-242-15
SNAI1
O95863
MPRSELVRKPSDPNR
QTHSDVKKYQCQACA
242

HR7520-1-247-15
SNAI1
O95863
MPRSFLVRKPSDPNR
VKKYQCQACARTFSR
247

HR7520-1-253-TEV
SNAI1
O95863
PRSFLVRKPSDPNRK
QACARTFSRMSLLHK
252

HR7520-15
SNAI1
O95863
MPRSFLVRKPSDPNR
LHKHQESGCSGCPR*
265

HR7520-34-264-Av6HT
SNAI1
O95863
PYDQAHLLAAIPPPE
LLHKHQESGCSGCPR
231

HR7520-40-264-15
SNAI1
O95863
MLLAAIPPPEILNPT
LLHKHQESGCSGCPR
226

HR7520-45-264-15
SNAI1
O95863
MPPPEILNPTASLPM
LLHKHQESGCSGCPR
221

HR7012A-122-179-NHT
SNAI2
O43623
AIEAEKFQCNLCNKT
DKEYVSLGALKMHIR
58

HR7849A-212-292-NHT
SNAI3
Q3KNW1
KICGKAFSRPWLLQG
SLLARHEESGCCPGP
81

HR7971A-346-397-Av6HT
SNAPC4
Q5SXM2
RKEWTEEEDRMLTQL
DSMQLIYRWTKSLDP
52

HR7549A-165-287-NHT
SOHLH2
Q9NX45
EHLGYFPTDLFACSE
RFCKKQQTPIELSLP
123

HR7723A-49-131-TEV
SOX1
O00570
DRVKRPMNAFMVWSR
DYKYRPRRKTKTLLK
83

HR7246A-102-183-15
SOX10
P56693
MPHVKRPMNAFMVWA
PDYKYQPRRRKNGKA
83

HR7246A-109-178-15
SOX10
P56693
MNAFMVWAQAARRKL
HKKDHPDYKYQPRRR
71

HR7246A-127-178-15
SOX10
P56693
MPHLHNAELSKTLGK
HKKDHPDYKYQPRRR
53

HR7246A-91-179-15
SOX10
P56693
MPVRVNGASKSKPHV
KKDHPDYKYQPRRRK
90

HR7180A-31-110-Av6HT
SOX12
O15370
GWCKTPSGHIKRPMN
LRLKHMADYPDYKYR
80

HR7313A-421-500-TEV
SOX13
Q9UN79
SSHIKRPMNAFMVWA
EKYPDYKYKPRPKRT
80

HR7773A-2-88-TEV
SOX14
O95416
SKPSDHIKRPMNAFM
DYKYRPRRKPKNLLK
87

HR7489A-83-161-TEV
SOX18
P35713
SRIRRPMNAFMVWAK
RDHPNYKYRPRRKKQ
79

HR8317A-38-121-TEV
SOX2
P48431
PDRVKRPMNAFMVWS
DYKYRPRRKTKTLMK
84

HR8041A-6-88-TEV
SOX21
Q9Y651
DHVKRPMNAFMVWSR
DYKYRPRRKPKTLLK
83

HR7838A-132-219-TEV
SOX3
P41225
GGTDQDRVKRPMNAF
DYKYRPRRKTKTLLK
88

HR8424A-45-130-Av6HT
SOX4
Q06945
KADDPSWCKTPSGHI
RLKHMADYPDYKYRP
86

HR7351A-554-632-TEV
SOX5
P35711
PHIKRPMNAFMVWAK
EKYPDYKYKPRPKRT
79

HR7953A-619-697-TEV
SOX6
P35712
HNSNISKILGSRWKS
YKQLMRSRRQEMRQF
78

HR7275A-43-121-TEV
SOX7
Q9BT81
SRIRRPMNAFMVWAK
QDYPNYKYRPRRKKQ
79

HR7103A-102-174-Av6HT
SOX8
P57073
VKRPMNAFMVWAQAA
VQHKKDHPDYKYQPR
73

HR7103A-63-143-Av6HT
SOX8
P57073
RFPACIRDAVSQVLK
NAELSKTLGKLWRLL
81

HR7103A-63-150-Av6HT
SOX8
P57073
RFPACIRDAVSQVLK
LGKLWRLLSESEKRP
88

HR7103A-63-173-NHT
SOX8
P57073
RFPACIRDAVSQVLK
RVQHKKDHPDYKYQP
111

HR7103A-82-143-Av6HT
SOX8
P57073
SLVPMPVRGGGGGAL
NAELSKTLGKLWRLL
62

HR7103A-82-150-Av6HT
SOX8
P57073
SLVPMPVRGGGGGAL
LGKLWRLLSESEKRP
69

HR7103A-82-173-Av6HT
SOX8
P57073
SLVPMPVRGGGGGAL
RVQHKKDHPDYKYQP
92

HR6433-64-495-15
SOX9
P48436
SEEDKFPVCIREAVS
ADTSGVPSIPQTHSP
432

HR6433-64-509-14
SOX9
P48436
SEEDKFPVCIREAVS
PQHWEQPVYTQLTRP
446

HR6433-68-490-15
SOX9
P48436
KFPVCIREAVSQVLK
MYTPIADTSGVPSIP
423

HR6433-68-509-14
SOX9
P48436
KFPVCIREAVSQVLK
PQHWEQPVYTQLTRP
442

HR4634C-496-558-14
SP1
P08047
MSSSNTTLTPIASAA
VHPIQGLPLAIANAP
64

HR4744B-38-153-14
SP100
P23497
MFTEDQGVDDRLLYD
HIYKGFENVIHDKLP
117

HR4744B-42-149-14
SP100
P23497
MQGVDDRLLYDIVFK
PDLIHIYKGFENVIH
109

HR4744B-70-135-14
SP100
P23497
MKTFPFLEGLRDRDL
VLEALFSDVNMQEYP
67

HR4744B-70-149-14
SP100
P23497
MKTFPFLEGLRDRDL
PDLIHIYKGFENVIH
81

HR4744C-595-684-TEV
SP100
P23497
DENINFKQSELPVTC
MENKFLPEPPSTRKK
90

HR7625A-677-739-NHT
SP140
Q13342
SQNNSSVDPCMRNLD
RTPWNCIFCRMKESP
63

HR7855A-523-581-Av6HT
SP2
Q02086
KKHVCHIPDCGKTFR
TRSDELQRHARTHTG
59

HR8154A-336-382-Av6HT
SP5
Q6BEB4
SFTRSDELQRHLRTH
SDHLAKHVKTHQNKK
47

HR7866A-256-329-Av6HT
SP6
Q3SY56
CHIPGCGKAYAKTSH
PCAVCSRVFMRSDHL
74

HR7872A-292-352-Av6HT
SP7
Q8TDD2
PIHSCHIPGCGKVYG
SDELERHVRTHTREK
61

HR7447A-131-213-TEV
SPDEF
O95238
LKDIETACKLLNITA
GDVLHAHLDIWKSAA
83

HR8383A-169-257-NHT
SPI1
P17947
KKIRLYQFLLDLLRS
KKVKKKLTYQFSGEV
89

HR4679B-130-262-14
SPIB
Q01892
MEEEDLPLDSPALEV
TYQFDSALLPAVRRA
134

HR4679B-134-262-14
SPIB
Q01892
MLPLDSPALEVSDSE
TYQFDSALLPAVRRA
130

HR4679B-163-262-14
SPIB
Q01892
MAGTRKKLRLYQFLL
TYQFDSALLPAVRRA
101

HR4679B-168-262-14
SPIB
Q01892
MKLRLYQFLLGLLTR
TYQFDSALLPAVRRA
96

HR7954A-111-207-Av6HT
SPIC
Q8N5J4
LRLFEYLHESLYNPE
FSEAILQRLSPSYFL
97

HR7260A-815-910-NHT
SRCAP
Q6ZRS2
IEGSQEYNEGLVKRL
QLRKVCNHPNLFDPR
96

HR7260B-583-850-Av6HT
SRCAP
Q6ZRS2
EITDIAAAAESLQPK
FLLRRVKVDVEKQMP
268

HR7260B-597-840-Av6HT
SRCAP
Q6ZRS2
KGYTLATTQVKTPIP
VKRLHKVLRPFLLRR
244

HR7260B-601-850-Av6HT
SRCAP
Q6ZRS2
LATTQVKTPIPLLLR
FLLRRVKVDVEKQMP
250

HR7260B-607-840-Av6HT
SRCAP
Q6ZRS2
KTPIPLLLRGQLREY
VKRLHKVLRPFLLRR
234

HR7260B-607-850-Av6HT
SRCAP
Q6ZRS2
KTPIPLLLRGQLREY
FLLRRVKVDVEKQMP
244

HR4448F-14
SREBF1
P36956
VLLFVYGEPVTRPHS
VVRTSLWRQQQPPAP
432

HR4448G-521-624-14
SREBF1
P36956
MVYHSPGRNVLGTES
RALGRPLPTSHLDLA
105

HR4448G-521-643-14
SREBF1
P36956
MVYHSPGRNVLGTES
WNLIRHLLQRLWVGR
124

HR4448G-526-619-14
SREBF1
P36956
MGRNVLGTESRDGPG
LWLALRALGRPLPTS
95

HR4448G-526-638-14
SREBF1
P36956
MGRNVLGTESRDGPG
ACSLLWNLIRHLLQR
114

HR4448G-530-624-14
SREBF1
P36956
MLGTESRDGPGWAQW
RALGRPLPTSHLDLA
96

HR4448G-530-643-14
SREBF1
P36956
MLGTESRDGPGWAQW
WNLIRHLLQRLWVGR
115

HR4448G-535-619-14
SREBF1
P36956
MRDGPGWAQWLLPPV
LWLALRALGRPLPTS
86

HR4448G-535-638-14
SREBF1
P36956
MRDGPGWAQWLLPPV
ACSLLWNLIRHLLQR
105

HR4448H-319-400-TEV
SREBF1
P36956
QSRGEKRTAHNAIEK
SLRTAVHKSKSLKDL
82

HR4448H-TEV
SREBF1
P36956
QSRGEKRTAHNAIEK
SLRTAVHKSKSLKDL
82

HR6329A-1075-1134-14
SREBF2
Q12772
MPGQRERATAILLAC
RSCNDCQQMIVKLGG
61

HR4543C-132-223-TEV
SRF
P11831
SGAKPGKKTRGRVKI
ETGKALIQTCLNSPD
92

HR6924A-56-131-Av6HT
SRY
Q05066
VQDRVKRPMNAFIVW
QAMHREKYPNYKYRP
76

HR6924A-56-131-TEV
SRY
Q05066
VQDRVKRPMNAFIVW
QAMHREKYPNYKYRP
76

HR7075A-105-202-Av6HT
SSB
P05455
KNDVKNRSVYIKGFP
YFAKKNEERKQNKVE
98

HR7075A-105-202-TEV
SSB
P05455
KNDVKNRSVYIKGFP
YFAKKNEERKQNKVE
98

HR7013A-305-448-TEV
SSH2
Q76I76
DSPTQIFEHVFLGSE
SFMRQLEEYQGILLA
143

HR7844A-287-452-NHT
SSH3
Q8TE77
DLESVTSKEIRQALE
QALRHVQELRPIARP
166

HR3575-1-551-14
SSRP1
Q08945
MAETLEFNDVYQEVK
EVKKGKDPNAPKRPM
551

HR3575-1-556-14
SSRP1
Q08945
MAETLEFNDVYQEVK
KDPNAPKRPMSAYML
556

HR3575-1-573-14
SSRP1
Q08945
MAETLEFNDVYQEVK
NASREKIKSDHPGIS
573

HR5522A-14
SSRP1
Q08945
MLKKAKMAKDRKSRK
RDYEKAMKEYEGGRG
101

HR5522A-15
SSRP1
Q08945
MLKKAKMAKDRKSRK
RDYEKAMKEYEGGRG
101

HR7020A-812-906-TEV
ST18
O60284
PELKCPVIGCDGQGH
GCPLNAQVIKKGKVS
95

HR8389A-136-710-Av6HT
STAT1
P42224
LDKQKELDSKVRNVK
PKGTGYIKTELISVS
575

HR8389A-136-710-NHT
STAT1
P42224
LDKQKELDSKVRNVK
PKGTGYIKTELISVS
575

HR8389A-136-710-TEV
STAT1
P42224
LDKQKELDSKVRNVK
PKGTGYIKTELISVS
575

HR3569D-573-771-14
STAT2
P52630
NDGRIMGFVSRSQER
STLEPVIEPTLGMVS
199

HR3569E-1-131-14
STAT2
P52630
MAQWEMLQNLDSPFQ
RILIQAQRAQLEQGE
131

HR3569E-1-186-14
STAT2
P52630
MAQWEMLQNLDSPFQ
VFCFRYKIQAKGKTP
186

HR5539A-14
STAT2
P52630
MAQWEMLQNLDSPFQ
LEEKRILIQAQRAQL
127

HR5539A-15
STAT2
P52630
MAQWEMLQNLDSPFQ
LEEKRILIQAQRAQL
127

HR5535A-1-101-14
STAT3
P40763
MAQWNQLQQLDTRYL
KQFLQSRYLEKPMEI
101

HR5535A-14
STAT3
P40763
MAQWNQLQQLDTRYL
WEESRLLQTAATAAQ
124

HR5535B-1-116-14
STAT3
P40763
MAQWNQLQQLDTRYL
ARIVARCLWEESRLL
116

HR5535B-1-133-14
STAT3
P40763
MAQWNQLQQLDTRYL
AATAAQQGGQANHPT
133

HR3612-187-748-14
STAT4
Q14765
MNSAMVNQEVLTLQE
PTTIETAMKSPYSAE
563

HR5542A-14
STAT5A
P42229
MAGWIQAQQLQGDAL
NEQRLVREANNCSSP
129

HR5542A-15
STAT5A
P42229
MAGWIQAQQLQGDAL
NEQRLVREANNCSSP
129

HR55428-128-712-NHT
STAT5A
P42229
SPAGILVDAMSQKHL
QIKQVVPEFVNASAD
585

HR5541A-1-102-14
STAT5B
P51692
MAVWIQAQQLQGEAL
GHYATQLQNTYDRCP
102

HR5541A-1-106-14
STAT5B
P51692
MAVWIQAQQLQGEAL
TQLQNTYDRCPMELV
106

HR5541A-14
STAT5B
P51692
MAVWIQAQQLQGEAL
NEQRLVREANNGSSP
129

HR5541A-15
STAT5B
P51692
MAVWIQAQQLQGEAL
NEQRLVREANNGSSP
129

HR5541B-1-127-14
STAT5B
P51692
MAVWIQAQQLQGEAL
LYNEQRLVREANNGS
127

HR5541B-1-135-14
STAT5B
P51692
MAVWIQAQQLQGEAL
REANNGSSPAGSLAD
135

HR5541C-1-684-TEV
STAT5B
P51692
AVWIQAQQLQGEALH
FPDRPKDEVYSKYYT
683

HR3396C-1-127-14
STAT6
P42226
MSLWGLVSKMPPEKV
QFRHLPMPFHWKQEE
127

HR3396C-1-169-14
STAT6
P42226
MSLWGLVSKMPPEKV
AEAGQVSLHSLIETP
169

HR3396C-1-174-14
STAT6
P42226
MSLWGLVSKMPPEKV
VSLHSLIETPANGTG
174

HR3396D-72-655-14
STAT6
P42226
GEGSTILQHISTLES
YVPATIKMTVERDQP
584

HR3396E-90-279-14
STAT6
P42226
RDPLKLVATFRQILQ
LRTLVTSCFLVEKQP
190

HR3396E-90-327-14
STAT6
P42226
RDPLKLVATFRQILQ
ADMVTEKQARELSVP
238

HR3396F-1-630-TEV
STAT6
P42226
SLWGLVSKMPPEKVQ
YPKKPKDEAFRSHYK
629

HR7864A-355-443-TEV
TADA2A
O75478
SNSGRRSAPPLNLTG
KIYDFLIREGYITKG
89

HR8503A-244-333-Av6HT
TADA2B
B3KX99
KEDGKDSEFAAIENL
LNSLTESGWISRDAS
90

HR4753B-177-253-14
TAL1
P17542
MEITDGPHTKVVRRI
LAKLLNDQEEEGTQR
78

HR4753B-177-280-14
TAL1
P17542
MEITDGPHTKVVRRI
GGGGGGGGGAPPDDL
105

HR4753B-182-247-14
TAL1
P17542
MPHTKVVRRIFTNSR
MKYINFLAKLLNDQE
67

HR4753B-182-262-14
TAL1
P17542
MPHTKVVRRIFTNSR
EEGTQRAKTGKDPVV
82

HR4753B-182-262-Av6HT
TAL1
P17542
PHTKVVRRIFTNSRE
EEGTQRAKTGKDPVV
81

HR4753B-182-262-TEV
TAL1
P17542
PHTKVVRRIFTNSRE
EEGTQRAKTGKDPVV
81

HR4753B-182-287-14
TAL1
P17542
MPHTKVVRRIFTNSR
GGAPPDDLLQDVLSP
107

HR6460A-1-79-15
TAL2
Q16559
MTRKIFTNTRERWRQ
QTGVAAQGNILGLFP
79

HR6460A-1-84-15
TAL2
Q16559
MTRKIFTNTRERWRQ
AQGNILGLFPQGPHL
84

HR6460A-1-96-15
TAL2
Q16559
MTRKIFTNTRERWRQ
PHLPGLEDRTLLENY
96

HR6460A-34-96-15
TAL2
Q16559
PDKKLSKNETLRLAM
PHLPGLEDRTLLENY
63

HR464-14
TAX1BP1
Q86VP1
MTSFQEVPLQTSNFA
NSDMLVVTTKAGLLE
151

HR464-21
TAX1BP1
Q86VP1
MTSFQEVPLQTSNFA
NSDMLVVTTKAGLLE
151

HR7030-1-512-TEV
TAX1BP1
Q86VP1
TSFQEVPLQTSNFAH
TSASTVDVKPSPSAA
511

HR7030-1-529-TEV
TAX1BP1
Q86VP1
TSFQEVPLQTSNFAH
DFDIVTKGQVCEMTK
528

HR7030-1-588-TEV
TAX1BP1
Q86VP1
TSFQEVPLQTSNFAH
ENVKLELAEVQDNYK
587

HR7030-1-597-TEV
TAX1BP1
Q86VP1
TSFQEVPLQTSNFAH
VQDNYKELKRSLENP
596

HR7030A-15-466-TEV
TAX1BP1
Q86VP1
AHVIFQNVAKSYLPN
KFKECQRLQKQINKL
452

HR7030A-15-470-TEV
TAX1BP1
Q86VP1
AHVIFQNVAKSYLPN
CQRLQKQINKLSDQS
456

HR8311A-205-394-Av6HT
TBR1
Q16650
QVYLCNRPLWLKFHR
LKIDHNPFAKGFRDN
190

HR8240A-138-330-Av6HT
TBX18
O95935
APRVDLQGAELWKRF
RLKIDRNPFAKGFRD
193

HR7379A-91-283-TEV
TBX2
Q13207
SLKSLEPEDEVEDDP
DKITQLKIDNNPFAK
193

HR7868A-127-326-Av6HT
TBX21
Q9UL17
LPAGLEVSGKLRVAL
QLKIDNNPFAKGFRE
200

HR7452A-91-277-NHT
TBX22
Q9Y458
DIQMELQGSELWKRF
QNQQITKLKIERNPF
187

HR7369A-99-311-TEV
TBX3
O15119
VEDDPKVHLEAKELW
LTLQSMRVFDERHKK
213

HR7232A-61-248-Av6HT
TBX4
P57082
EQTIENIKVGLHEKE
KITQLKIENNPFAKG
188

HR8313A-52-232-Av6HT
TBX5
Q99593
EGIKVFLHERELWLK
QNHKITQLKIENNPF
181

HR7389A-90-273-NHT
TBX6
O95947
GVSLSLENRELWKEF
QLKIAANPFAKGFRE
184

HR6334A-578-637-TEV
TCF12
Q99081
RRMANNARERLRVRD
AVAVILSLEQQVRER
60

HR6965A-1-144-Av6HT
TCF19
Q9Y242
MLPCFQLLRIGGGRG
DFAAITIPRSRGEAR
144

HR6965A-1-144-NHT
TCF19
Q9Y242
LPCFQLLRIGGGRGG
DFAAITIPRSRGEAR
143

HR8141A-73-167-Av6HT
TCF21
O43680
SQEGKQVQRNAANAR
PFMVAGKPESDLKEV
95

HR7160A-75-162-NHT
TCF23
Q7RTU1
SEASPENAARERSRV
LRYLHPLKKWPMRSR
88

HR7366A-178-588-Av6HT
TCF25
Q9BQ70
LYVEHRHLNPDTELK
DVTTQSVMGFDPLPP
411

HR4404E-550-609-TEV
TCF3
P15923
RRVANNARERLRVRD
AVSVILNLEQQVRER
60

HR4645C-565-624-TEV
TCF4
P15884
RRMANNARERLRVRD
AVAVILSLEQQVRER
60

HR8064A-27-105-TEV
TEAD1
P28347
IDNDAEGVWSPDIEQ
SSHIQVLARRKSRDF
79

HR7830A-40-115-TEV
TEAD2
Q15562
DAEGVWSPDIEQSFD
SSHIQVLARRKSREI
76

HR7697A-27-104-TEV
TEAD3
Q99594
LDNDAEGVWSPDIEQ
VSSHIQVLARKKVRE
78

HR6976A-217-434-TEV
TEAD4
Q15561
RSVASSKLWMLEFSA
SEHGAQHHIYRLVKE
218

HR7931A-446-500-Av6HT
TERF2
Q15554
KKQKWTVEESEWVKA
MIKDRWRTMKRLGMN
55

HR7931A-446-500-TEV
TERF2
Q15554
KKQKWTVEESEWVKA
MIKDRWRTMKRLGMN
55

HR7939A-132-190-Av6HT
TERF2IP
Q9NYB0
GRIAFTDADDVAILT
SWQSLKDRYLKHLRG
59

HR7939A-132-190-TEV
TERF2IP
Q9NYB0
GRIAFTDADDVAILT
SWQSLKDRYLKHLRG
59

HR8166A-153-218-TEV
TFAM
Q00059
GKPKRPRSAYNVYVA
AKEDETRYHNEMKSW
66

HR3078B-202-418-14
TFAP2A
P05549
GGVVNPNEVFCSVPG
EALKAMDKMYLSNNP
217

HR3078B-207-414-14
TFAP2A
P05549
PNEVFCSVPGRLSLL
NYLTEALKAMDKMYL
208

HR3162-15
TFAP2B
Q92481
MHSPPRDQAAIMLWK
GPGSKTGDKEEKHRK
460

HR7501-139-450-15
TFAP2C
Q92754
MRRDAYRRSDLLLPH
ADSNKTLEKMEKHRK
313

HR7501A-206-427-TEV
TFAP2C
Q92754
NLPCQKELVGAVMNP
QNYIKEALIVIDKSY
222

HR7501A-219-427-TEV
TFAP2C
Q92754
NPTEVFCSVPGRLSL
QNYIKEALIVIDKSY
209

HR7501B-128-430-Av6HT
TFAP2C
Q92754
LSGLEAGAVSARRDA
IKEALIVIDKSYMNP
303

HR7501B-128-450-Av6HT
TFAP2C
Q92754
LSGLEAGAVSARRDA
ADSNKTLEKMEKHRK
323

HR7501B-139-430-TEV
TFAP2C
Q92754
RRDAYRRSDLLLPHA
IKEALIVIDKSYMNP
292

HR7501B-206-450-TEV
TFAP2C
Q92754
NLPCQKELVGAVMNP
ADSNKTLEKMEKHRK
245

HR7501B-219-450-TEV
TFAP2C
Q92754
NPTEVFCSVPGRLSL
ADSNKTLEKMEKHRK
232

HR7272A-212-422-Av6HT
TFAP2E
Q6VUC0
TNPGEVFCSVPGRLS
YLLESLKGLDKMFLS
211

HR7122A-21-122-Av6HT
TFAP4
Q01664
EKEVIGGLCSLANIP
QQNTQLKRFIQELSG
102

HR7110A-303-394-15
TFCP2
Q12800
MLGEGNGSPNHQPEP
ALKGRMVRPRLTIYV
93

HR7110A-303-400-15
TFCP2
Q12800
MLGEGNGSPNHQPEP
VRPRLTIYVCQESLQ
99

HR7110A-303-404-15
TFCP2
Q12800
MLGEGNGSPNHQPEP
LTIYVCQESLQLREQ
103

HR7110A-332-395-15
TFCP2
Q12800
MEAQQWLHRNRFSTF
LKGRMVRPRLTIYVC
65

HR7110A-332-399-15
TFCP2
Q12800
MEAQQWLHRNRFSTF
MVRPRLTIYVCQESL
69

HR7110A-332-404-15
TFCP2
Q12800
MEAQQWLHRNRFSTF
LTIYVCQESLQEREQ
74

HR7022A-278-385-NHT
TFCP2L1
Q9NZI6
SPNSFGLGEGNASPT
MTIYVCQELEQNRVP
108

HR4671B-105-200-TEV
TFDP1
Q14186
RNRKGEKNGKGLRHF
KKEIKWIGLPTNSAQ
96

HR7048A-121-215-TEV
TFDP2
Q14188
RRRVYDALNVLMAMN
QNQGPPALNSTIQLP
95

HR7261A-244-347-NHT
TFDP3
Q5H9I0
QRPLPNSVIHVPFII
AQGTFGGVFTTAGSR
104

HR4665C-333-388-14
TFE3
P19532
MISETEAKALLKERQ
PKSSDPEMRWNKGTI
57

HR4665C-333-443-14
TFE3
P19532
MISETEAKALLKERQ
ELELQAQIHGLPVPP
112

HR4665C-338-383-14
TFE3
P19532
MAKALLKERQKKDNH
LGTLIPKSSDPEMRW
47

HR665C-338-438-14
TFE3
P19532
MAKALLKERQKKDNH
QLRIQELELQAQIHG
102

HR7480A-223-309-NHT
TFEB
P19484
TDAESRALAKERQKK
SRELENHSRRLEMTN
87

HR4411B-151-237-14
TGIF1
Q15583
MDIPLDLSSSAGSGK
LPDMLRKDGKDPNQF
88

HR4411B-170-232-14
TGIF1
Q15583
MNLPKESVQILRDWL
ARRRLLPDMLRKDGK
64

HR4411B-170-252-14
TGIF1
Q15583
MNLPKESVQILRDWL
TISRRGAKISETSSV
84

HR4411B-171-248-14
TGIF1
Q15583
MLPKESVQILRDWLY
PNQFTISRRGAKISE
79

HR4411B-189-248-14
TGIF1
Q15583
MNAYPSEQEKALLSQ
PNQFTISRRGAKISE
61

HR4411C-171-241-14
TGIF1
Q15583
MLPKESVQILRDWLY
LRKDGKDPNQFTISR
72

HR4393-12-199-15
TGIF2
Q9GZN2
LLSLAGKRKRRGNLP
PTPPEQDKEDFSSFQ
188

HR4393-12-223-15
TGIF2
Q9GZN2
LLSLAGKRKRRGNLP
AAEMELQKQQDPSLP
212

HR4393-17-220-15
TGIF2
Q9GZN2
GKRKRRGNLPKESVK
LQRAAEMELQKQQDP
204

HR4393-6-199-15
TGIF2
Q9GZN2
LGEDEGLLSLAGKRK
PTPPEQDKEDFSSFQ
194

HR4393-6-223-15
TGIF2
Q9GZN2
LGEDEGLLSLAGKRK
AAEMELQKQQDPSLP
218

HR7881A-51-127-TEV
TGIF2LX
Q8IUE1
KKRKGNLPAESVKIL
LQQRRNDPIIGHKTG
77

HR8232A-51-127-NHT
TGIF2LY
Q8IUE0
KKRKGNLPAESVKIL
LQQRRNDPIIGHKTG
77

HR8232A-51-127-TEV
TGIF2LY
Q8IUE0
KKRKGNLPAESVKIL
LQQRRNDPIIGHKTG
77

HR7047A-1-87-TEV
THAP1
Q9NVV9
VQSCSAYGCKNRYDK
KENAVPTIFLCTEPH
86

HR1517A-1-91-Av6HT
THAP10
Q9P2Z0
PARCVAAHCGNTTKS
QRLRLVAGAVPTLHR
90

HR7799A-1-67-TEV
THAP11
Q96EK4
PGFTCCVPGCYNNSH
QPTTGHRLCSVHFQG
66

HR7799A-1-72-TEV
THAP11
Q96EK4
PGFTCCVPGCYNNSH
HRLCSVHFQGGRKTY
71

HR7799A-1-82-Av6HT
THAP11
Q96EK4
PGFTCCVPGCYNNSH
GRKTYTVRVPTIFPL
81

HR8301A-1-87-TEV
THAP2
Q9H0W7
PTNCAAAGCATTYNK
MDAVPTIFDFCTHIK
86

HR7028A-1-83-NHT
THAP5
Q7Z6K1
PRYCAAICCKNRRGR
RWGIRYLKQTAVPTI
82

HR8415A-1-149-Av6HT
THAP6
Q8TBB0
VKCCSAIGCASRCLP
QFIFEHSYSVMDSPK
148

HR7818A-1-92-Av6HT
THAP7
Q9BT49
PRHCSAAGCCTRDTR
ISGYHRLKEGAVPTI
91

HR6978A-1-82-15
THAP8
Q8NA92
MPKYCRAPNCSNTAG
QWRWGVRYLRPDAVP
82

HR6978A-1-87-15
THAP8
Q8NA92
MPKYCRAPNCSNTAG
VRYLRPDAVPSIFSR
87

HR6978A-16-87-15
THAP8
Q8NA92
MRLGADNRPVSFYKF
VRYLRPDAVPSIFSR
73

HR6978A-21-82-15
THAP8
Q8NA92
MNRPVSFYKFPLKDG
QWRWGVRYLRPDAVP
63

HR7271A-1-88-NHT
THAP9
Q9H5L6
TRSCSAVGCSTRDTV
YGIRRKLKKGAVPSV
87

HR7130A-202-461-15
THRB
P10828
MEELQKSIGHKPEPT
PTELFPPLFLEVFED
261

HR7130A-202-461-Av6HT
THRB
P10828
EELQKSIGHKPEPTD
PTELFPPLFLEVFED
260

HR7130A-202-461-TEV
THRB
P10828
EELQKSIGHKPEPTD
PTELFPPLFLEVFED
260

HR7130B-104-206-15
THRB
P10828
MDELCVVCGDKATGY
IEENREKRRREELQK
104

HR7130B-104-206-Av6HT
THRB
P10828
DELCVVCGDKATGYH
IEENREKRRREELQK
103

HR7130B-104-206-TEV
THRB
P10828
DELCVVCGDKATGYH
IEENREKRRREELQK
103

HR6921A-74-139-NHT
TIGD3
Q6B0B8
SKYSGIDEALLCWYH
VRWKRRNNVGFGARH
66

HR7457A-14-77-NHT
TIGD4
Q8IY51
TVKKKKSLSIEEKID
VLEAFESLRFDPKRK
64

HR7206A-68-132-NHT
TIGD6
Q17RP2
KRMRSALYDDIDKAV
QASVGWLNRFRDRHG
65

HR7729A-62-136-NHT
TIGD7
Q6NT04
PLVGAEKRKRTTGAK
STGWLFRFRNRHAIG
75

HR7316A-298-418-NHT
TIPARP
Q7Z3E1
NDRMRMKYGGQEFWA
LFRSCFILLPYLQTL
121

HR7535A-206-260-TEV
TLX1
P31314
TSFTRLQICELEKRF
KTWFQNRRTKWRRQT
55

HR6480A-162-216-TEV
TLX2
O43763
TSFSRSQVLELERRF
KTWFQNRRTKWRRQT
55

HR7241A-171-225-TEV
TLX3
O43711
TSFSRVQICELEKRF
KTWFQNRRTKWRRQT
55

HR3551B-1-370-TEV
TNFAIP3
P21580
AEQVLPQALYLSNMR
WQENSEQGRREGHAQ
369

HR8218A-34-319-Av6HT
TOE1
Q96GM8
VPVVDVQSNNFKEMW
AYGWCPLGPQCPQSH
286

HR5174A-643-706-NHT
TOP3A
Q13472
QQEDIYPAMPEPIRK
PDSVLEASRDSSVCP
64

HR8243A-244-339-NHT
TOX
O94900
GKKPKTPKKKKKKDP
LAAYRASLVSKSYSE
96

HR8243A-244-339-TEV
TOX
O94900
GKKPKTPKKKKKKDP
LAAYRASLVSKSYSE
96

HR7258A-238-302-TEV
TOX2
Q96NM4
VASMWDSLGEEQKQA
STQANPPAKMLPPKQ
65

HR7680A-238-335-TEV
TOX3
O15405
GKKPKTPKKKKKKDP
AYRASLVSKAAAESA
98

HR7250A-206-291-TEV
TOX4
O94842
GKKQKAPKKRKKKDP
EAAKKEYLKALAAYK
86

HR6989-94-312-15-TEV
TP53
P04637
MLSSSVPSQKTYQGS
ELPPGSTKRALPNNT
221

HR6989-94-312-R175H-15-TEV
TP53
P04637
MLSSSVPSQKTYQGS
ELPPGSTKRALPNNT
221

HR6989A-20-73-Av6HT
TP53
P04637
SDLWKLLPENNVLSP
GPDEAPRMPEAAPPV
54

HR6989A-20-73-TEV
TP53
P04637
SDLWKLLPENNVLSP
GPDEAPRMPEAAPPV
54

HR3500C-14
TP63
Q9H3D4
MDALSPSPAIPSNTD
GTKRPFRQNTHGIQM
232

HR3500C-15
TP63
Q9H3D4
MDALSPSPAIPSNTD
GTKRPFRQNTHGIQM
232

HR3500D-540-614-TEV
TP63
Q9H3D4
PPPYPTDCSIVSFLA
GILDHRQLHEFSSPS
75

HR3466-110-636-14
TP73
O15350
MSPAPVIPSNTDYPG
RKQPIKEEFTEAEIH
528

HR3466-114-636-14
TP73
O15350
MVIPSNTDYPGPHHF
RKQPIKEEFTEAEIH
524

HR3466D-14
TP73
O15350
MSPAPVIPSNTDYPG
KADEDHYREQQALNE
209

HR3466D-15
TP73
O15350
MSPAPVIPSNTDYPG
KADEDHYREQQALNE
209

HR3466E-487-554-TEV
TP73
O15350
YHADPSLVSFLTGLG
TIWRGLQDLKQGHDY
68

HR8230A-78-139-TEV
TRAFD1
O14545
HEETECPLRLAVCQH
VKDLKTHPEVCGREG
62

HR4455D-876-951-14
TRERF1
Q96PN7
MCHPLANYHYAGSDK
LGRKHRTRLAEIIDD
77

HR4455D-881-945-14
TRERF1
Q96PN7
MNYHYAGSDKWTSLE
WKKIMRLGRKHRTRL
66

HR4455E-773-1200-15
TRERF1
Q96PN7
MQTVDVEPRINIGLR
LDDQDSVLLQGDAEL
429

HR4455E-778-1200-15
TRERF1
Q96PN7
MEPRINIGLRFQAEI
LDDQDSVLLQGDAEL
424

HR4455F-773-841-15
TRERF1
Q96PN7
MQTVDVEPRINIGLR
ENLLNLCCSSALPGG
70

HR4455F-778-836-15
TRERF1
Q96PN7
MEPRINIGLRFQAEI
LQQRVENLLNLCCSS
60

HR7441A-22-107-NHT
TRIM23
P36406
GTAVVKVLECGVCED
FALLELLERLQNGPI
86

HR7486A-13-98-NHT
TRIM3
O75382
QPMDKQFLVCSICLD
SLMEAMQQAPDGAHD
86

HR7466A-4-90-TEV
TRIM32
Q13049
AAASHLNLDALREVL
LTDNLTVLKIIDTAG
87

HR5056A-48-428-Av6HT
TRIT1
Q9H3H1
GGEIVSADSMQVYEG
IKSKSHLNQLKKRRR
381

HR7683A-316-386-15
TSC22D4
Q9Y3Q8
MVGIDNKIEQAMDLV
EQLAQLPSSGVPRLG
72

HR7683A-320-381-15
TSC22D4
Q9Y3Q8
MNKIEQAMDLVKSHL
ALASPEQLAQLPSSG
63

HR7683A-320-395-Av6HT
TSC22D4
Q9Y3Q8
NKIEQAMDLVKSHLM
GVPRLGPPAPNGPSV
76

HR8019A-232-335-TEV
TSHZ1
Q6ZSZ6
DKDSEKTKRWSKPRK
EPAGMAAEVALSESA
104

HR7516A-824-951-NHT
TSHZ2
Q9NRE2
DVRRFEDVSSEVSTL
TPSTYISHLESHLGF
128

HR6901A-200-303-TEV
TSHZ3
Q63HK5
SSKLYGSIFTGASKF
DLSVHMIKTKHYQKV
104

HR7321A-615-661-Av6HT
TTF1
Q15361
NYKGRYSEGDTEKLK
ARSSLSVALKFSQIS
47

HR7321A-615-669-Av6HT
TTF1
Q15361
NYKGRYSEGDTEKLK
LKFSQISSQRNRGAW
55

HR7321A-615-678-Av6HT
TTF1
Q15361
NYKGRYSEGDTEKLK
RNRGAWSKSETRKLI
64

HR7321A-615-687-Av6HT
TTF1
Q15361
NYKGRYSEGDTEKLK
ETRKLIKAVEEVILK
73

HR7321A-615-697-NHT
TTF1
Q15361
NYKGRYSEGDTEKLK
EVILKKMSPQELKEV
83

HR8382A-244-506-NHT
TUB
P50607
GISSSMSFDEDEEDE
QSYVLNFHGRVTQAS
263

HR8277A-291-536-TEV
TULP1
O00294
PREFVLRPAPQGRTV
LCALQAFAIALSSFD
246

HR7732A-263-520-Av6HT
TULP2
O00295
SPCPGLEEDMEAYVL
FSPLQAFSICLSSFN
258

HR6409A-100-175-14
TWIST1
Q15672
PQSYEELQTQRVMAN
QVLQSDELDSKMASC
76

HR6409A-102-171-14
TWIST1
Q15672
SYEELQTQRVMANVR
DFLYQVLQSDELDSK
70

HR7529A-43-146-TEV
U2AF1
Q01081
SQTIALLNIYRNPQN
NRWFNGQPIHAELSP
104

HR7415B-479-562-Av6HT
UBTF
P17480
MEMTWNNMEKKEKLM
NGELNHLPLKERMVE
85

HR7415B-479-562-TEV
UBTF
P17480
EMTWNNMEKKEKLMW
NGELNHLPLKERMVE
84

HR8089A-89-170-Av6HT
UNCX
A6NJT0
KLSDSGDPDKESPGC
RRAKWRKKENTKKGP
82

HR7768A-197-260-TEV
USF1
P22415
DEKRRAQHNEVERRR
KACDYIQELRQSNHR
64

HR6458A-220-346-15
USF2
Q15853
PYSPKIDGTRTPRDE
LQQHNLEMVGEGTRQ
127

HR6458A-226-279-15
USF2
Q15853
DGTRTPRDERRRAQH
CNADNSKTGASKGGI
54

HR6458A-226-346-15
USF2
Q15853
DGTRTPRDERRRAQH
LQQHNLEMVGEGTRQ
121

HR6458B-226-330-15
USF2
Q15853
DGTRTPRDERRRAQH
QQIEELKNENALLRA
105

HR6458B-231-325-15
USF2
Q15853
PRDERRRAQHNEVER
NELLRQQIEELKNEN
95

HR8005-106-565-15
USP39
Q53GS9
MPYLDTINRSVLDFD
IWKRRDNDETNQQGA
461

HR8005A-189-554-15
USP39
Q53GS9
MITYVLKPTFTKQQI
QMITLSEAYIQIWKR
367

HR8005A-189-565-15
USP39
Q53GS9
MITYVLKPTFTKQQI
IWKRRDNDETNQQGA
378

HR8005A-194-549-15
USP39
Q53GS9
MKPTFTKQQIANLDK
TDILPQMITLSEAYI
357

HR8005A-194-555-15
USP39
Q53GS9
MKPTFTKQQIANLDK
MITLSEAYIQIWKRR
363

HR8005B-210-555-15
USP39
Q53GS9
MKLSRAYDGTTYLPG
MITLSEAYIQIWKRR
347

HR8005C-106-183-TEV
USP39
Q53GS9
PYLDTINRSVLDFDF
TLKFYCLPDNYEIID
78

HR8005C-129-183-TEV
USP39
Q53GS9
SHINAYACLVCGKYF
TLKFYCLPDNYEIID
55

HR6997A-81-167-NHT
VAX1
Q5SQQ9
DAKGSIREIILPKGL
TKQKKDQGKDSELRS
87

HR8032A-81-165-Av6HT
VAX2
Q9UIW0
VRDAKGTIREIVLPK
QNRRTKQKKDQSRDL
85

HR7564A-21-427-Av6HT
VDR
P11473
PRICGVCGDRATGFH
KLTPLVLEVFGNEIS
407

HR7564A-21-427-TEV
VDR
P11473
PRICGVCGDRATGFH
KLTPLVLEVFGNEIS
407

HR7564B-16-125-15
VDR
P11473
MFDRNVPRICGVCGD
KEEEALKDSLRPKLS
111

HR7564B-16-125-Av6HT
VDR
P11473
FDRNVPRICGVCGDR
KEEEALKDSLRPKLS
110

HR7564B-16-125-TEV
VDR
P11473
FDRNVPRICGVCGDR
KEEEALKDSLRPKLS
110

HR7703A-97-158-Av6HT
VENTX
O95231
AFTMEQVRTLEGVFQ
MKHKRQMQDPQLHSP
62

HR7928A-148-214-Av6HT
VSX1
Q9NZR4
EDRNDLKASPTLGKR
KTELPEDRIQVWFQN
67

HR8065A-153-211-Av6HT
VSX2
P58304
TIFTSYQLEELEKAF
QNRRAKWRKREKCWG
59

HR7106A-20-70-TEV
VTN
P04004
DQESCKGRCTEGFNV
AECKPQVTRGDVFTM
51

HR7713A-1017-1084-TEV
WDHD1
O75717
RPKTGFQMWLEENRS
KGETASEGTEAKKRK
68

HR7541A-815-891-NHT
WHSC1
O96028
AHFTARKGKRHHAHV
KLHFQDIIWVKLGNY
77

HR8130A-318-438-TEV
WT1
P19544
HSTGYESDNHTTPII
HQRRHTGVKPFQCKT
121

HR3172-15
XBP1
P17861
MVVVAAAPNPADGTP
CQWGRHQPSWKPLMN
261

HR8228A-98-208-TEV
XPA
P23025
EFDYVICEECGKEFM
WGSQEALEEAKEVRQ
110

HR8027A-52-129-TEV
YBX1
P67809
KKVIATKVLGTVKWF
EGEKGAEAANVTGPG
78

HR7254A-87-164-TEV
YBX2
Q9Y2T7
KPVLAIQVLGTVKWF
EGEKGAEATNVTGPG
78

HR7538A-193-335-NHT
YEATS2
Q9ULM3
RNADLTDETSRLFVK
AETVVDVELHRHSLG
143

HR8298A-14-147-15
YEATS4
O95619
MGRVKGVTIVKPIVY
TVVSEFYDEMIFQDP
135

HR8137A-293-414-TEV
YY1
P25490
PRTIACPHKGCTKMF
LKSHILTHAKAKNNQ
122

HR8207A-251-371-TEV
YY2
O15391
PKTVPCSYSGCEKMF
NLKTHILTHVKTKNN
121

HR7328A-23-83-TEV
ZBED1
O96006
SKVWKYFGFDTNAEG
KNHPEEFCEFVKSNT
61

HR7606A-49-119-TEV
ZBED2
Q9BTP6
NKGTRFSEAWFYFHL
MHREELEKSGHGQAG
71

HR8174A-11-69-15
ZBP1
Q9H171
MEGHLEQRILQVLTE
ELKVSLTSPATWCLG
60

HR8174A-26-69-15
ZBP1
Q9H171
MGSPVKLAQLVKECQ
ELKVSLTSPATWCLG
45

HR8174A-6-74-15
ZBP1
Q9H171
MADPGREGHLEQRIL
LTSPATWCLGGTDPE
70

HR7903A-21-117-Av6HT
ZBTB1
Q9Y2K1
GFLCDCCIAIDDIYF
YLQLYNVPDCLEDIQ
97

HR6940A-194-334-NHT
ZBTB11
O95625
PKHCQAVLKQLNEQR
KKGEVQTVASTQDLR
141

HR6940B-764-842-Av6HT
ZBTB11
O95625
RGYHCTQCEKSFFEA
GKEFYEKALFRRHVK
79

HR4454-14
ZBTB12
Q9Y330
MASGVEVLRFQLPGH
NVLEASVAEINVLIR
459

HR4454C-1-132-14
ZBTB12
Q9Y330
MASGVEVLRFQLPGH
KCRNALSQFIEPKIG
132

HR4454C-1-137-14
ZBTB12
Q9Y330
MASGVEVLRFQLPGH
LSQFIEPKIGLKEDG
137

HR4454C-1-151-14
ZBTB12
Q9Y330
MASGVEVLRFQLPGH
GVSEASLVSSISATK
151

HR4454D-328-447-14
ZBTB12
Q9Y330
MNPLKNIKCTKCPEV
HLKEQHGKTTAENVL
121

HR4454E-361-421-14
ZBTB12
Q9Y330
MCPRCGKQFNHSSNI
NLHSGARPYRCSYCD
62

HR4454E-366-418-14
ZBTB12
Q9Y330
MKQFNHSSNLNRHMN
DHLNLHSGARPYRCS
54

HR3471-145-673-15
ZBTB16
Q05516
MEEDRKARYLKNIFI
PDWRIEKTYLYLCYV
530

HR3471-150-673-15
ZBTB16
Q05516
MARYLKNIFISKHSS
PDWRIEKTYLYLCYV
525

HR3471-189-673-15
ZBTB16
Q05516
MTSFGLSAMSPTKAA
PDWRIEKTYLYLCYV
486

HR3471-194-673-15
ZBTB16
Q05516
MSAMSPTKAAVDSLM
PDWRIEKTYLYLCYV
481

HR4581F-2-115-TEV
ZBTB17
Q03105
DFPQHSQHVLEQLNQ
MQDIITACHALKSLA
114

HR7182A-1-107-15
ZBTB2
Q8N680
MDLANHGLILLQQLN
VRLEQGIKFLHAYPL
107

HR7182A-1-113-15
ZBTB2
Q8N680
MDLANHGLILLQQLN
IKFLHAYPLIQEASL
113

HR7182B-1-117-15
ZBTB2
Q8N680
MDLANHGLILLQQLN
HAYPLIQEASLASQG
117

HR7182B-1-147-15
ZBTB2
Q8N680
MDLANHGLILLQQLN
YGIQIADHQLRQATK
147

HR7182B-1-152-15
ZBTB2
Q8N680
MDLANHGLILLQQLN
ADHQLRQATKIASAP
152

HR7182C-227-390-15
ZBTB2
Q8N680
MSDEQPASLTIAHVK
SHWREHMYIHTGKPF
165

HR7182C-232-385-15
ZBTB2
Q8N680
MASLTIAHVKPSIMK
KFIQKSHWREHMYIH
155

HR7182C-245-390-15
ZBTB2
Q8N680
MKRNGSFPKYYACHL
SHWREHMYIHTGKPF
147

HR7182C-248-385-15
ZBTB2
Q8N680
MGSFPKYYACHLCGR
KFIQKSHWREHMYIH
139

HR7182C-252-385-15
ZBTB2
Q8N680
MKYYACHLCGRRFTL
KFIQKSHWREHMYIH
135

HR8336A-81-201-Av6HT
ZBTB20
Q9HC78
INLHNFSNSVLETLN
DECTRIVSQNVGDVF
121

HR7741A-30-151-NHT
Z8T822
O15209
AVVHVSFPEVTSALL
WHIVDKCTELLREGR
122

HR7877A-1-114-15
ZBTB25
P24278
MDTASHSLVLLQQLN
RFLHADYLSHIATEM
114

HR7877A-1-120-15
ZBTB25
P24278
MDTASHSLVLLQQLN
YLSHIATEMNQVFSP
120

HR7877A-1-138-15
ZBTB25
P24278
MDTASHSLVLLQQLN
QSSNLYGIQISTTQK
138

HR7877A-1-144-15
ZBTB25
P24278
MDTASHSLVLLQQLN
GIQISTTQKTVVKQG
144

HR7877B-231-376-15
ZBTB25
P24278
MTENSVKIHLCHYCG
SQLLEHMYTHKGKSY
147

HR7877B-236-373-15
ZBTB25
P24278
MKIHLCHYCGERFDS
PRKSQLLEHMYTHKG
139

HR7877B-244-373-15
ZBTB25
P24278
MGERFDSRSNLRQHL
PRKSQLLEHMYTHKG
131

HR7877B-261-373-15
ZBTB25
P24278
MVSGSLPFGVPASII
PRKSQLLEHMYTHKG
114

HR7877B-270-376-15
ZBTB25
P24278
MPASILESNDLGEVH
SQLLEHMYTHKGKSY
108

HR7877B-275-373-15
ZBTB25
P24278
MESNDLGEVHPLNEN
PRKSQLLEHMYTHKG
100

HR7422A-1-129-NHT
ZBTB26
Q9HCK0
SERSDLLHFKFENYG
IVERCTQALWKFIKP
128

HR6960A-46-179-NHT
ZBTB3
Q9H5J0
PSWGTMEFPEHSQQL
CKRRLQARALAEADS
134

HR7977A-1-110-Av6HT
ZBTB32
Q9Y2Y4
SLPPIRLPSPYGSDR
AARALGVQSLEEACW
109

HR7008A-1-116-TEV
ZBTB33
Q86T24
ESRKLISATDIQYSG
IKSGQLLGVKFIAEL
115

HR6893A-1-124-NHT
ZBTB34
Q8NCN2
DSSSFIQFDVPEYSS
QMQCVIDKCTQILES
123

HR7018A-1-125-NHT
ZBTB37
Q5TC79
EKGGNIQLEIPDFSN
MQHIIDKCTQILEGI
124

HR7837A-13-139-NHT
ZBTB38
Q8NAP3
DFHSDTVLSILNEQR
RNFSNSPGPYVFCIT
127

HR7896A-1-125-Av6HT
ZBTB39
O15060
GMRIKLQSTNHPNNL
MEDLLQACHSTFPDL
124

HR7527A-1-112-NHT
ZBTB40
Q9NUA8
ELPNYSRQLLQQLYT
DSLQMFDVAVSCKNL
111

HR8293A-24-183-Av6HT
ZBTB41
Q5SVQ8
EGNVAVECDQVTYTH
DAVKLLNNENVAPFH
160

HR7772A-367-467-TEV
ZBTB43
O43298
SATDKLYPCQCGKSF
SYEAAKAEQNTTEAN
101

HR7772B-1-126-15
ZBTB43
O43298
MEPGTNSFRVEFPDF
MWHVVDKCTEVLEGN
126

HR7772B-1-137-15
ZBTB43
O43298
MEPGTNSFRVEFPDF
LEGNPTVLCQKLNHG
137

HR7772C-10-126-Av6HT
ZBTB43
O43298
VEFPDFSSTILQKLN
MWHVVDKCTEVLEGN
117

HR7772C-10-131-Av6HT
ZBTB43
O43298
VEFPDFSSTILQKLN
DKCTEVLEGNPTVLC
122

HR7772C-29-131-15
ZBTB43
O43298
MQGQLCDVSIVVQGH
DKCTEVLEGNPTVLC
104

HR7772C-29-137-15
ZBTB43
O43298
MQGQLCDVSIVVQGH
LEGNPTVLCQKLNHG
110

HR7772C-33-126-15
ZBTB43
O43298
MCDVSIVVQGHIFRA
MWHVVDKCTEVLEGN
95

HR7772C-33-131-15
ZBTB43
O43298
MCDVSIVVQGHIFRA
DKCTEVLEGNPTVLC
100

HR8333A-1-128-15
ZBTB44
Q8NCP5
MGVKTFTHSSSSHSQ
FSVASTCSEFMKSSI
128

HR8333A-1-133-15
ZBTB44
Q8NCP5
MGVKTFTHSSSSHSQ
TCSEFMKSSILWNTP
133

HR7817A-6-125-NHT
ZBTB45
Q96K62
AVHHIHLQNFSRSLL
IQTVIDECTQIIARA
120

HR7445A-291-405-NHT
ZBTB48
P10074
VECPTCHKKFLSKYY
KDLQSHMIKLHGAPK
115

HR7445A-291-405-TEV
ZBTB48
P10074
VECPTCHKKFLSKYY
KDLQSHMIKLHGAPK
115

HR7445B-4-120-TEV
ZBTB48
P10074
SFVQHSVRVLQELNK
EAVELCQSFKPKTSV
117

HR7910A-1-125-Av6HT
ZBTB49
Q6ZSB9
DPVATHSCHLLQQLH
SLCHTFLKSATVVQP
124

HR7620A-1-125-NHT
ZBTB5
O15062
DFPGHFEQIFQQLNY
VVKACKHYLTTRTLP
124

HR8300A-1-134-Av6HT
ZBTB6
Q15916
AAESDVLHFQFEQQG
TEALSKYLEIDLSMK
133

HR4695C-9-128-TEV
ZBTB7A
O95365
IGIPFPDHSSDILSG
LEIPAVSHVCADLLD
120

HR8347A-1-143-Av6HT
ZBTB7B
O15156
GSPEDDLIGIPFPDH
EIPCVIAACMEILQG
142

HR7365A-6-129-NHT
ZBTB7C
A1YPR0
DELIGIPFPNHSSEV
EIQCIVNVCLEIMEP
124

HR8095A-1-121-Av6HT
ZBTB8A
Q96BR9
EISSHQSHLLQQLNE
MTDVISVCKTFIKSS
120

HR7919A-1-131-Av6HT
ZBTB8B
Q8NAP8
EMQSYYAKLLGELNE
YIRSSLDICRKMEKE
130

HR7153A-20-140-NHT
ZBTB9
Q96C00
PRTIQIEFPQHSSSL
QMMQVVDQCSEILRE
121

HR6996-34-350-Av6HT
ZC3H15
Q8WU90
KKGAKQQKFIKAVTH
LYIPRDVDETGITVA
317

HR7121A-417-503-TEV
ZC3H4
Q9UPT8
ELPKKRELCKFYITG
GAEDEKEVEELKKQG
87

HR7136A-892-947-TEV
ZC3H7A
Q8IWR0
QYCWQHRFPTGYFSI
WEERRDALKMKLNKA
56

HR6981A-218-283-NHT
ZC3H8
Q8N5P1
EIEKKKEMCKFYVQG
APLTPETQELLAKVI
66

HR8421A-724-896-TEV
ZC3HAV1
Q7Z2W4
SSKKYKLSEIHHLHP
KDQVYPQYVIEYTED
173

HR4840-1-454-14
ZCCHC4
Q9H5U6
MAASRNGFEAVEAEG
GPKHGCFICGELDHK
454

HR4840-1-459-14
ZCCHC4
Q9H5U6
MAASRNGFEAVEAEG
CFICGELDHKRSTCP
459

HR4840-102-513-14
ZCCHC4
Q9H5U6
MLSRTQCVERYLKFI
RRKKRRERAHQYLGS
413

HR4840-41-454-14
ZCCHC4
Q9H5U6
MPHGPTLLFVKVTQG
GPKHGCFICGELDHK
415

HR4840-41-459-14
ZCCHC4
Q9H5U6
MPHGPTLLFVKVTQG
CFICGELDHKRSTCP
420

HR4840-41-513-14
ZCCHC4
Q9H5U6
MPHGPTLLFVKVTQG
RRKKRRERAHQYLGS
474

HR7192A-927-1161-Av6HT
ZCCHC6
Q5VYS8
SLKEENVCEEKNSPV
LCYTMKVFTKMCDIG
235

HR4656C-161-443-14
ZEB1
P37275
MGTPDAFSQLLTCPY
LENNQANLASKEQET
284

HR4656C-165-439-14
ZEB1
P37275
MAFSQLLTCPYCDRG
IRQVLENNQANLASK
276

HR4656D-885-1017-14
ZEB1
P37275
MNDSDSTPPKKKMRK
PEILSNEHVGARASP
134

HR4656D-885-992-14
ZEB1
P37275
MNDSDSTPPKKKMRK
HMNHRYSYCKREAEE
109

HR4656D-890-1014-14
ZEB1
P37275
MTPPKKKMRKTENGM
EAGPEILSNEHVGAR
126

HR4656D-890-987-14
ZEB1
P37275
MTPPKKKMRKTENGM
GSYSQHMNHRYSYCK
99

HR4656D-897-1014-14
ZEB1
P37275
MRKTENGMYACDLCD
EAGPEILSNEHVGAR
119

HR4656D-897-987-14
ZEB1
P37275
MRKTENGMYACDLCD
GSYSQHMNHRYSYCK
92

HR4656E-583-642-TEV
ZEB1
P37275
SPSQPPLKNLLSLLK
WFEKMQAGQISVQSS
60

HR4589D-647-707-Av6HT
ZEB2
O60315
MSPINPYKDHMSVLK
EQRKVYQYSNSRSPS
62

HR4589D-647-707-TEV
ZEB2
O60315
SPINPYKDHMSVLKA
EQRKVYQYSNSRSPS
61

HR6404A-128-196-TEV
ZFAND5
O76080
SPSVSQPSTSQSEEK
DKHNCPYDYKAEAAA
69

HR8363-123-190-Av6HT
ZFAND6
Q6FIF0
SVSDTAQQPSEEQSK
SDVHNCSYNYKADAA
68

HR7859A-697-770-TEV
ZFHX2
Q9C0A1
LGSSSDSLPTSPPPD
DTHRCKLCCYGTQLK
74

HR7545B-1398-1452-Av6HT
ZFHX3
Q15911
VYKYRCNQCSLAFKT
FRTFQALKKHLETSH
55

HR7545B-1398-1483-Av6HT
ZFHX3
Q15911
VYKYRCNQCSLAFKT
ANGDLLAMGDPTLAE
86

HR7545C-2943-2998-Av6HT
ZFHX3
Q15911
RPGQKRFRTQMTNLQ
GLPKRVVQVWFQNAR
56

HR7545C-2943-3010-Av6HT
ZFHX3
Q15911
RPGQKRFRTQMTNLQ
NARAKEKKSKLSMAK
68

HR7545C-2954-3005-Av6HT
ZFHX3
Q15911
TNLQLKVLKSCFNDY
QVWFQNARAKEKKSK
52

HR7545C-2954-3010-Av6HT
ZFHX3
Q15911
TNLQLKVLKSCFNDY
NARAKEKKSKLSMAK
57

HR7573D-2953-3003-TEV
ZFHX4
Q86UP3
TPTMQECEMLGNEIG
INIGKPFMINQGGTE
51

HR8105A-360-407-Av6HT
ZFP1
Q6P2D0
TFSQRSTLRLHCRIH
SRLSVHQRVHIGEKP
48

HR7592A-1509-1806-Av6HT
ZFP106
Q9H2Y7
SSEISSEPGDDDEPT
MIYTGCYDGSIQAVR
298

HR7696A-237-310-NHT
ZFP112
Q9UJU3
GEDIMKVSLLNQESI
NYSSLLHIHQNIERE
74

HR7929A-142-207-Av6HT
ZFP14
Q9HCL3
QVKITSEKMTTYKRH
IHTGEKPYKCKECGQ
66

HR7835A-8-127-NHT
ZFP161
O43829
SETIKYNDDDHKTLF
QILGIRFLDKLCSQK
120

HR7794A-82-137-NHT
ZFP2
Q6ZN57
DATQNSELIKTQRMF
IHTGEKPYKCNVCGK
56

HR7491A-224-296-NHT
ZFP28
Q8NHY6
LFETQPGLVTIKNLA
QEKEPWWVKRELTGS
73

HR7037A-395-483-Av6HT
ZFP3
Q96NJ6
CFECGKAFRRTSHLI
RIHTGEKPYECQECQ
89

HR7776A-306-378-NHT
ZFP30
Q9Y2G7
AFLCSTGLRLHHKLH
SRGYHLTLHQRIHTG
73

HR4743B-99-171-TEV
ZFP36
P26651
TTPSRYKTELCRTFS
PYGSRCHFIHNPSED
73

HR7685A-112-181-TEV
ZFP36L1
Q07352
SSRYKTELCRPFEEN
CPYGPRCHFIHNAEE
70

HR7167A-151-220-TEV
ZFP36L2
P47974
STRYKTELCRPFEES
CPYGPRCHFIHNADE
70

HR7105A-571-623-NHT
ZFP37
Q9Y6Q3
KPYECNECEKAFNAK
TFKQNASLTKHVKTH
53

HR7063A-83-140-NHT
ZFP41
Q8N8Y5
RKKPYECSECGRIFK
HSSDVTKHQRTHTGE
58

HR7124A-165-241-NHT
ZFP42
Q96MM3
PKQLAEFARKKPPIN
VESSKLKRHFLVHTG
77

HR7554A-339-397-TEV
ZFP64
Q9NPA5
SEHPEKCSECSYSCS
PSNLSKHMKKFHGDM
59

HR7612A-318-373-Av6HT
ZFP82
Q8N141
AFLCGSGLRVHHKLH
THTGFKPYECKECGK
56

HR7734A-483-537-NHT
ZFP90
Q8TF47
AFSQQAISHPGEKPY
KPYECNECGEAFSRR
55

HR7784A-364-427-15
ZFP91
Q96JP5
MKHHTDQRDYICEYC
ASLNWHMKKHDADSF
65

HR7784A-370-422-15
ZFP91
Q96JP5
MRDYICEYCARAFKS
TCRQKASLNWHMKKH
54

HR7784A-370-456-15
ZFP91
Q96JP5
MRDYICEYCARAFKS
KDSVVAHKAKSHPEV
88

HR7784B-313-454-Av6HT
ZFP91
Q96JP5
CEMEGCGTVLAHPRY
EKKDSVVAHKAKSHP
142

HR7665A-150-204-NHT
ZFP92
A6NM28
KRYLCQQCGKAFSRS
RRSFALLEHQRIHSG
55

HR7876A-297-383-Av6HT
ZFPM1
Q8IX07
CRKSCPSASSLEIHM
TNHMVCQPGSKGEIY
87

HR7512A-673-743-NHT
ZFX
P17010
RPSELKKHVAAHKGK
RQQSELKKHMKTHSG
71

HR8053A-728-784-Av6HT
ZFYVE20
Q9H1K0
PEAEEPIEEELLLQQ
RELKHTLAKQKGGTD
57

HR8053B-133-256-15
ZFYVE20
Q9H1K0
MAFDRTNTESAKIRA
DEKDDDRIRCCTHCK
125

HR8053B-133-276-15
ZFYVE20
Q9H1K0
MAFDRTNTESAKIRA
REQQIDEKEHTPDIV
145

HR8053B-139-251-15
ZFYVE20
Q9H1K0
MTESAKIRAIEKSVV
VSSVLDEKDDDRIRC
114

HR8053B-139-273-15
ZFYVE20
Q9H1K0
MTESAKIRAIEKSVV
LLKREQQIDEKEHTP
136

HR8053B-150-251-15
ZFYVE20
Q9H1K0
MSVVPWVNDQDVPFC
VSSVLDEKDDDRIRC
103

HR8053B-150-273-15
ZFYVE20
Q9H1K0
MSVVPWVNDQDVPFC
LLKREQQIDEKEHTP
125

HR7907A-60-153-TEV
ZHX1
Q9UKY1
NQQNKKVEGGYECKY
NNQTIFEQTINQLTF
94

HR7907B-565-641-TEV
ZHX1
Q9UKY1
PDFTPQKFKEKTAEQ
EEKMEIDESNAGSSK
77

HR7907C-295-358-Av6HT
ZHX1
Q9UKY1
NNPLLLNTYNKFPYP
TPEEVEEARRKQFNG
64

HR7907D-768-820-Av6HT
ZHX1
Q9UKY1
NWDRGPSLIKFKTGT
KSHMGYEQVREWFAE
53

HR7907D-768-830-Av6HT
ZHX1
Q9UKY1
NWDRGPSLIKFKTGT
EWFAERQRRSELGIE
63

HR7907E-658-720-Av6HT
ZHX1
Q9UKY1
SGSTGKICKKTPEQL
SWFGDTRYAWKNGNL
63

HR7907E-658-728-Av6HT
ZHX1
Q9UKY1
SGSTGKICKKTPEQL
AWKNGNLKWYYYYQS
71

HR7907F-462-532-Av6HT
ZHX1
Q9UKY1
PDSFGIRAKKTKEQL
NQRNSKSNQCLHLNN
71

HR7907F-468-513-Av6HT
ZHX1
Q9UKY1
RAKKTKEQLAELKVS
KITGLTKGEIKKWFS
46

HR7907F-468-532-Av6HT
ZHX1
Q9UKY1
RAKKTKEQLAELKVS
NQRNSKSNQCLHLNN
65

HR8292A-524-605-NHT
ZHX2
Q9Y6X8
AYPDFAPQKFKEKTQ
VLDSMGSGKKGQDVG
82

HR8292A-524-605-TEV
ZHX2
Q9Y6X8
AYPDFAPQKFKEKTQ
VLDSMGSGKKGQDVG
82

HR7743A-613-675-TEV
ZHX3
Q9H4I2
PTKYKERAPEQLRAL
SERRKKVNAEETKKA
63

HR7728A-219-303-TEV
ZIC1
Q15915
QPIKQELICKWIEPE
LVNHIRVHTGEKPFP
85

HR7748A-250-334-TEV
ZIC2
O95409
QCIKQELICKWIDPE
LVNHIRVHTGEKPFP
85

HR8404A-122-262-NHT
ZIC4
Q8N9L1
QPIKQELICKWLAAD
SSDRKKHSHVHTSDK
141

HR8404A-122-262-TEV
ZIC4
Q8N9L1
QPIKQELICKWLAAD
SSDRKKHSHVHTSDK
141

HR7356A-417-487-NHT
ZIK1
Q3SY52
SQSSILIQHRRIHTG
SQCSSLIHHQKCHNT
71

HR7796A-474-527-NHT
ZIM2
Q9NZV7
VFSRNSYLIQHYRTH
YQLHSQAEKTVECDHC
54

HR8306A-277-331-Av6HT
ZIM3
Q96PE6
KSYQCNECEKSFRQN
IYKSDLVKHQRIHTG
55

HR8102A-61-140-Av6HT
ZKSCAN1
P17029
RFCYQNTFGPREALS
RAVTLLEDLELDLSG
80

HR8296A-7-131-Av6HT
ZKSCAN2
Q63HK3
SQIDAPLEVEGCLIM
VALVVHLEKETGRLR
125

HR7446A-37-132-NHT
ZKSCAN3
Q9BRR0
SPDLGSEGSRERFRG
VVLLEYLERQLDERA
96

HR7362A-49-138-NHT
ZKSCAN4
Q969J2
PERSRQRFRGFRYPE
VVVLLEYLERQLDEP
90

HR7407A-25-130-NHT
ZKSCAN5
Q9Y2L8
LFIVKVEEEDCTWMQ
ESGEEAVAVIENIQR
106

HR7288A-62-140-NHT
ZMAT2
Q96NC0
LGKTIVITKTTPQSE
FEVNKKKMEEKQKDY
79

HR7490-503-839-Av6HT
ZMIZ1
Q9ULI6
PVANYPHSPVPGNPT
VPIKSDLHIKDDPDG
337

HR7144A-212-289-NHT
ZNF10
P21506
SNECGQTFCQNIHLI
SWRSNLTRHQLIHTG
78

HR8024A-409-481-Av6HT
ZNF100
Q8IYN0
GFNWSSALTKHKRIH
NRSSQLTAHKMIHTG
73

HR8250A-364-426-Av6HT
ZNF101
Q8IZC7
KPYECTRCGKAFGWC
HERTHLAGRSQCFGR
63

HR7096A-555-620-15
ZNF107
Q9UII5
MEEHGKVFNQSSNLT
KPHKCEECGKAYNRF
67

HR7096A-560-615-15
ZNF107
Q9UII5
MVFNQSSNLTTQKII
IYTGEKPHKCEECGK
57

HR7096B-607-719-Av6HT
ZNF107
Q9UII5
PHKCEECGKAYNRFS
SNLTTHKKIHTSEKP
113

HR7096C-611-676-15
ZNF107
Q9UII5
MEECGKAYNRFSNLT
KPYKCKECGKAFNLS
67

HR7096C-616-671-15
ZNF107
Q9UII5
MAYNRFSNLTIHKRI
IHTGEKPYKCKECGK
57

HR7096D-53-131-15
ZNF107
Q9UII5
MECTGHKGGHNTVNQ
SQLTQHRRIHTRVNS
80

HR7096D-58-126-15
ZNF107
Q9UII5
MKGGHNTVNQCLTAT
SFCVLSQLTQHRRIH
70

HR7096D-69-131-15
ZNF107
Q9UII5
MTATPSKIFQCNKYV
SQLTQHRRIHTRVNS
64

HR7096D-71-126-15
ZNF107
Q9UII5
MTPSKIFQCNKYVKV
SFCVLSQLTQHRRIH
57

HR7096E-158-269-TEV
ZNF107
Q9UII5
KPYKCEECGKAFNQS
LFSNLTNHKRIHAGE
112

HR7096F-672-727-Av6HT
ZNF107
Q9UII5
AFNLSSTLTAHKKIH
IHTSEKPYKCEECGK
56

HR7096G-659-772-Av6HT
ZNF107
Q9UII5
TGEKPYKCKECGKAF
NLSSNLTTHKKIHTG
114

HR7096H-702-776-Av6HT
ZNF107
Q9UII5
NQSSNLTTHKKIHTS
NLTTHKKIHTGEKPY
75

HR7096H-716-776-Av6HT
ZNF107
Q9UII5
SEKPYKCEECGKSFN
NLTTHKKIHTGEKPY
61

HR8087A-338-417-Av6HT
ZNF114
Q8NC26
GKAFRYSLHLNKHLR
LKKHLKTHKDEKPCE
80

HR7502A-318-390-NHT
ZNF121
P58317
GKAFATSSQLIEHIR
AYNRFYLLTKHLKTH
73

HR7834A-112-166-NHT
ZNF132
P52740
KANSCDMCGPFLKDI
WLNANLHQHQKEHSG
55

HR7007A-48-120-NHT
ZNF134
P52741
TALPCDICGPILKDI
LRRDKSEASIVKNCT
73

HR8079A-458-526-Av6HT
ZNF136
P52737
SYLNSFRTHEMIHTG
AYSCRASFQRHMLTH
69

HR8523A-1-79-Av6HT
ZNF137P
P52743
NVARFLVEKHTLHVI
IHGVGKLCKCNDCHK
78

HR6957A-157-213-NHT
ZNF140
P52738
VERPYGCHECGKTFG
SQISNLVKHQMIHTG
57

HR7470A-405-474-NHT
ZNF141
Q15928
RRSTDRSQHKKIHSA
FKRFSHLNKHKKIHT
70

HR8111A-337-394-Av6HT
ZNF143
P52747
SFTTSNIRKVHVRTH
IHTGEKPYVCTVPGC
58

HR8395A-1-68-Av6HT
ZNF146
Q15072
SHLSQQRIYSGENPF
SQKQYVIKHQNTHTG
67

HR3636C-225-287-NHT
ZNF148
Q9UQR1
KPFRCDECGMRFIQK
HKRMCHENHDKKLNR
63

HR7492A-160-244-NHT
ZNF154
Q13106
CYICSECGKSFSKSY
SNLIKHRRVHTGERP
85

HR8099A-408-497-Av6HT
ZNF155
Q12901
GFYTNSQLSSHQRSH
PFKCEDCGKRLVHRT
90

HR7481A-394-466-NHT
ZNF157
P51786
AFYVKARLIEHQRMH
YVKVRLIEHQRIHTG
73

HR7426A-245-317-NHT
ZNF16
P17020
TFSQNSVLKNRHRSH
SQNSSLKKHQKSHMS
73

HR7677A-461-550-Av6HT
ZNF160
Q9HCG1
AFSMHSNLATHQVIH
PYKCIECGKSFTQKS
90

HR8279A-12-131-Av6HT
ZNF165
P49910
NSPEDEGLLIVKIEE
GEEAVTILEDLERGT
120

HR7169A-37-134-NHT
ZNF167
Q9P0L1
GQGSSLQKNYPPVCE
ESGEEAVAVVEDFQR
98

HR7079A-232-286-NHT
ZNF169
Q14929
KHHVCPECGRGFCQR
SQKASLSIHQRKHSG
55

HR8144A-504-578-Av6HT
ZNF17
P17021
GKSFRCRSTLDTHQR
SQNSHLIRHQKVHTR
75

HR7831A-37-132-TEV
ZNF174
Q15697
KNCPDPELCRQSFRR
VTLVEDFHRASKKPK
96

HR7382A-565-650-NHT
ZNF175
Q9Y473
GKAFTSKSQFKEHQR
THMGEKPYECLDCGK
86

HR8386A-246-321-Av6HT
ZNF177
Q13360
STGSYLIVHKRTHTG
LIMHKRIHNGQKLHE
76

HR8047A-6-143-Av6HT
ZNF18
P17022
GQALGLLPSLAKAED
WISIQVLGQDILSEK
138

HR7449A-517-602-Av6HT
ZNF180
Q9UIW8
GEKPFECNQCGKSFS
QSYVLVVHQRTHTGE
86

HR7508A-221-306-NHT
ZNF181
Q2M3W8
QGKSLTLPQTCNREK
PYKCIECGKAFSHVS
86

HR7707A-292-396-NHT
ZNF189
Q75820
KCKKSFSRNSLLVEH
SQLCNLTRHQRIHTG
105

HR8281A-147-213-Av6HT
ZNF19
P17023
IQGKVPRIPCARKPF
NGNSSLIRHQRIHTG
67

HR8500A-45-132-Av6HT
ZNF192
Q15776
LGQEVFRLRFRQLRY
NGEEVVTLLEDLERQ
88

HR7141A-10-132-NHT
ZNF193
O15535
SLGVQVPEAWEELLT
ESGEEAVILLEDLER
123

HR7496A-33-148-NHT
ZNF197
O14709
SSSSVWETSHLHFRQ
LVKDQDTLQKVVSAP
116

HR7949A-310-387-Av6HT
ZNF20
P17024
PYECKQCGKAFRCGS
GKGFRCASQLQIHER
78

HR7725A-16-132-NHT
NF202
O95125
EGILMVKLEDDFTCR
VTLVEGLQKQPRRPR
117

HR7127A-305-371-NHT
ZNF205
O95201
RKSYRCEQCGKGFSW
IHTGEKPYTCPACRK
67

HR8501A-1095-1149-Av6HT
ZNF208
O43345
KPYKCEECGKAFSTF
SWLSVFSKHKKIHTG
55

HR7117A-425-476-NHT
ZNF212
Q9UDV6
SSLICGYCGKSFSHP
KSFVQKQHLLQHQKI
52

HR7052A-50-129-NHT
ZNF213
O14771
QFCYGDVHGPHEAFS
EAVALVEDLQKQPVK
80

HR6908A-201-269-NHT
ZNF214
Q9UL59
VGVICQEDLLRDSME
CFSQRSDLYRHPRNH
69

HR8316A-49-130-Av6HT
ZNF215
Q9UL58
QKFRHFQYLKVSGPH
SKDMVTLIEDVIEML
82

HR7041A-127-180-NHT
ZNF217
O75362
EFSCEVCGQTFRVAF
KEPWFLKNHMRTHNG
54

HR7381A-39-109-NHT
ZNF219
Q9P2Y4
SLGMGAVSWSESRAG
AQRALLRSHLRTHQP
71

HR7603A-137-200-Av6HT
ZNF22
P17026
MKPYQCDECGRCFSQ
MKVHKEEKPRKTRGK
65

HR7603A-137-200-NHT
ZNF22
P17026
KPYQCDECGRCFSQS
MKVHKEEKPRKTRGK
64

HR7848A-283-341-Av6HT
ZNF222
Q9UK12
KLYKSEKYGRGFIDR
YLLVHQRVHTGEKPY
59

HR8507A-136-200-Av6HT
ZNF223
Q9UK11
EGLSIMHTGQKPSNC
CYISALHIHQRVHLG
65

HR7500A-576-665-Av6HT
ZNF225
Q9UK10
SFSRASSILNHKRLH
LLQCEDCGKSIVHSS
90

HR7826A-501-553-NHT
ZNF226
Q9NYT6
KPYKCNECGKSFRRN
GFSQSSYLQIHQKAH
53

HR7039-1-527-TEV
ZNF227
Q86WZ6
PSQNYDLPQKKQEKM
VHTGEKRFKCETCGK
526

HR7039-255-799-Av6HT
ZNF227
Q86WZ6
CGRGFSYSPRLPLHP
SRLTYHQKVHTGKKL
545

HR7039-320-799-Av6HT
ZNF227
Q86WZ6
GEKSYRCDSCGKGFS
SRLTYHQKVHTGKKL
480

HR7039A-21-80-Av6HT
ZNF227
Q86WZ6
EAVTFKDVAVVFSRE
PFQPDMVSQLEAEEK
60

HR7249A-552-607-NHT
ZNF229
Q9UJW7
SFGRSSDLHIHQRVH
VHTGERPYVCDVCGK
56

HR8056A-178-248-Av6HT
ZNF23
P17027
RCDSQLIQHQENNTE
SYSSHYITHQTIHSG
71

HR7277A-201-287-Av6HT
ZNF230
Q9UIE0
RGKEFSQSSCLQTRE
IHTGEKPFKCEICGK
87

HR7779A-56-136-Av6HT
ZNF232
Q9UNY5
EEEQSCEYETRLPGN
LVLEQFLTILPEELQ
81

HR7083A-324-410-NHT
ZNF233
A6NK53
SQGSHLQPHQRVSTG
RACKCDVYDKGFSQT
87

HR7425A-606-678-Av6HT
ZNF234
Q14588
SQASSLQLHQSVHTG
RSNLVSHHKIHAAGT
73

HR6869A-681-738-NHT
ZNF235
Q14590
KPYTCQQCGKGFSQA
SHLIYHQRVHTGGNL
58

HR7932A-71-144-Av6HT
ZNF236
Q9UL36
CPQTFNVEFNLTLHK
FTLQSQLAVHMEEHR
74

HR7756A-1-111-NHT
ZNF238
Q99592
EFPDHSRHLLQCLSE
VLAAASYLHMYDIVK
110

HR7813A-381-458-NHT
ZNF239
Q16600
GKGFSQSSDLRIHLR
SNLHIHQRVHKKDPR
78

HR7147A-272-331-TEV
ZNF24
P17028
IHSGEKPYGCVECGK
SQNSGLINHQRIHTG
60

HR7147B-49-112-Av6HT
ZNF24
P17028
EIFRQRFRQFGYQDS
EQFVAILPKELQTWV
64

HR7147B-49-117-Av6HT
ZNF24
P17028
EIFRQRFRQFGYQDS
ILPKELQTWVRDHHP
69

HR7147B-49-138-Av6HT
ZNF24
P17028
EIFRQRFRQFGYQDS
VTVLEDLESELDDPG
90

HR7111A-518-570-Av6HT
ZNF248
Q8NDW4
KPYKCNECGKTFCEK
TFSQRSVLTKHQRIH
53

HR7751A-154-226-NHT
ZNF25
P17030
SESKNEDLIRHQKIH
YQKPHLTEHQKTHTG
73

HR6988A-235-324-NHT
ZNF250
P15622
AFSQSSVLSKHRRIH
PYVCPLCGKAFNHST
90

HR7737A-208-296-Av6HT
ZNF253
O75346
AFNQSANLTTHKRIH
KPYKCEECGKAFKHP
89

HR6990A-584-652-NHT
ZNF254
O75437
NRSSTFTKHKVIHTG
AFNRSSHLTTDKITH
69

HR8384A-202-266-Av6HT
ZNF256
Q9Y2P7
VAFHSVKNHYNWGEC
CSLSDHLRVHTSEKP
65

HR7634A-464-533-Av6HT
ZNF26
P17031
PRKASLQIHQKTHSG
FCWNSGLRIHRKTHK
70

HR8255A-134-188-Av6HT
ZNF260
Q3ZCT1
KPYACKECGKAFNGK
SQKQYLIKHQNIHTG
55

HR7211A-35-111-NHT
ZNF263
O14978
PSPEASHLRFRRFRF
IQSRVQELHPESGEE
77

HR6888A-230-294-Av6HT
ZNF264
O43296
PYECTECGKTFIKST
IHSGEKPYKCNECGK
65

HR8327A-276-365-Av6HT
ZNF266
Q14584
AFTVSSCLSQHMKIH
PYKCKDCGKAFTQNS
90

HR6896A-62-137-NHT
ZFN268
Q14587
LEWLFISQEQPKITK
QHTKPDIIFKLEQGE
76

HR8262A-158-241-Av6HT
ZNF273
Q14593
VHKRGYNGLNQCLTT
TATRVNFYKCKTCGK
84

HR7968A-77-161-Av6HT
ZNF276
Q8N554
GHCRLCHGKFSSRSL
HSLLKSFLQRVNASP
85

HR8173A-209-282-Av6HT
ZNF277
Q9NRM2
NCNEFLCTLQKKLDN
ELGKSWEEVQLEDDR
74

HR8391A-440-492-Av6HT
ZNF280C
Q8ND82
KNLLCPFCLKVSKMA
QFLTSKEKAEHKAQH
53

HR7724A-288-373-NHT
ZNF281
Q9Y2X9
PFQCSQCSMGFIQKY
RLLKHRRTCGEVIVK
86

HR7574A-86-180-Av6HT
ZNF282
Q9UDV7
REPQLPTAEISLWTV
RRLENLENLLRNRNF
94

HR6982A-569-623-NHT
ZNF283
Q8N7M2
KPFKCKECGKAFSWG
GSGYQLSVHQRFHTG
55

HR8101A-140-217-Av6HT
ZNF284
Q2VY69
IHIGETPSEHGKCKK
YKCDVCSKAFSQNSQ
78

HR7778A-510-590-NHT
ZNF285
Q96NJ3
KPYKCDECGKGFSRN
DLLTHQRLHEQRETL
81

HR7046A-197-250-NHT
ZNF286A
Q9HBT8
SFNQKSVLITEDRVP
TYKEKKPHKCNDCGE
54

HR7764A-1340-1400-TEV
ZNF292
O60281
PEKVKKDRGRGPNGK
NPRSLGGHLSKRSYC
61

HR7764B-550-593-Av6HT
ZNF292
O60281
EFLGHRIVRHAQKHY
NSKETFVPHVTLHVK
44

HR7764C-779-824-Av6HT
ZNF292
O60281
AKCMFPKCGRIFSEA
KFTGCGKVYRSQGEL
46

HR7764C-779-829-Av6HT
ZNF292
O60281
AKCMFPKCGRIFSEA
GKVYRSQGELEKHLD
51

HR7401A-713-806-TEV
ZNF295
Q9ULJ3
ASPVENKEVYQCRLC
RHQVEVHNQNNMAPT
94

HR7401B-907-958-Av6HT
ZNF295
Q9ULJ3
SLWPCEKCGKMFTVH
KAFRTNFRLWSHFQS
52

HR7401B-907-963-Av6HT
ZNF295
Q9ULJ3
SLWPCEKCGKMFTVH
NFRLWSHFQSHMSQA
57

HR7401C-1-125-Av6HT
ZNF295
Q9ULJ3
EGLLHYINPAHAISL
ISFLTNIVSKTPQAP
124

HR7401C-1-133-Av6HT
ZNF295
Q9ULJ3
EGLLHYINPAHAISL
SKTPQAPFPTCPNRK
132

HR7401D-1-110-Av6HT
ZNF295
Q9ULJ3
EGLLHYINPAHAISL
KSSLAAVQELGYSLG
109

HR7401D-1-114-Av6HT
ZNF295
Q9ULJ3
EGLLHYINPAHAISL
AAVQELGYSLGISFL
113

HR7438A-396-451-NHT
ZNF296
Q8WUU4
TNSSNLTVHRRSHTG
GMTPGSTRFECPHCH
56

HR7980A-567-639-Av6HT
ZNF304
Q9HCX3
AYISSSHLVQHKKVH
SRSSHLVRHQKAHTG
73

HR6886A-245-327-NHT
ZNF311
Q5JNZ3
KLHECARCGKNFSWH
NSRSALCRHKKTHSG
83

HR8348A-456-510-Av6HT
ZNF319
Q9P2F9
KPLRCTLCERRFFSS
KYASDLQRHRRVHTG
55

HR7649A-335-419-Av6HT
ZNF320
A2RRD8
DKVFSRKSHLERHRR
KLHTGEKLYECEECD
85

HR7116A-290-344-NHT
ZNF322A
Q6U7Q0
THTFKCLEYEKSFNC
FLLGMDFVAQQKMRT
55

HR7719-1-389-Av6HT
ZNF322B
Q5SYY0
YTSEEKCNQRTQKRK
GEKPFVCNVSEKGLE
388

HR7473A-7-125-NHT
ZNF323
Q96LW9
QYDLKIVKVEEDPIW
VAVVEDLEQELSEPG
119

HR7209A-240-309-NHT
ZNF324
O75467
PSTWDELGEALHAGE
SQTSHLTQHQRIHSG
70

HR7920A-181-255-Av6HT
ZNF329
Q86UD4
ENIFTLSSSLNENQR
SKNYNLIVHQRIHTG
75

HR8085A-409-463-Av6HT
ZNF331
Q9NQX6
KPYGCTECGKSFSHG
NHLNHLREHQRIHNS
55

HR8071A-542-633-Av6HT
ZNF333
Q96JL9
VLSRLSTLKSHMRTH
QCNQCEKAFRHSSSL
92

HR7926A-511-568-Av6HT
ZNF334
Q9HCZ1
NTKENLYECSEHGHA
CRKSALTHHQRTHTG
58

HR8140A-560-612-Av6HT
ZNF335
Q9H4Z2
SSFPCPVCGRVYPMQ
SFKKRYTFKMHLLTH
53

HR7962A-683-744-Av6HT
ZNF337
Q9Y3M9
KPFVCQECKRGYTSK
KHLKRHLREKRFCTG
62

HR7329A-327-374-NHT
ZNF33B
Q06732
KHFECNECGKAFWEK
NQCGKTFWEKSNLTK
48

HR7973A-53-101-Av6HT
ZNF343
Q6P1L6
EGKAQIVVPVTFRDV
YKEVMLENYRNLLSL
49

HR7782A-408-478-NHT
ZNF345
Q14585
SSGSALNRHQRIHTG
GRDSEFQQHKKSHNG
71

HR8375A-52-156-Av6HT
ZNF346
Q9UL40
QPVGREEVEHMIQKN
TFSSPVVAQSHYLGK
105

HR7359A-200-274-NHT
ZNF35
P13682
GGKYSLNSGAVKNPK
IQSANLVVHQRIHTG
75

HR7521A-532-605-NHT
ZNF354A
O60765
GQSSALIQHRRIHTG
SSLTNHYKIHIEEDP
74

HR8204A-166-238-Av6HT
ZNF354B
Q96LW1
NFYLKSVFIKQQRFA
IHNSSLRKHQKNHTG
73

HR7986A-494-548-Av6HT
ZNF354C
Q86Y25
KLYKCMECGKAYSYR
ICSSSLTQYQRFFKG
55

HR8492A-212-270-Av6HT
ZNF355P
Q9NSJ1
CKCEECGKACKQSLG
IHAGEKPYNCEKCGK
59

HR7559A-189-242-NHT
ZNF358
Q9NW07
SHGATLAQHRGIHTG
SHSGEKPHHCPVCGK
54

HR8534A-152-309-Av6HT
ZNF365
Q70YC5
DTKASFEAHVREKFN
QQASGFVRDLSGHVL
158

HR7222A-233-319-NHT
ZNF366
Q8N895
DVNVQIDDSYYVDVG
GTRPHKCQVCHKAFT
87

HR7913A-160-248-Av6HT
ZNF367
Q7RTV3
GEHSSSRIRCNICNR
SRFTHANRHCPKHPY
89

HR8143A-116-153-Av6HT
ZNF37A
P17032
EPSEYNKNGNSFWLN
IKNWEQSFEYNECGK
38

HR7024A-370-456-NHT
ZNF383
Q8NA42
ECGKAFTQSSQLRQH
RIHTGEKPYNCKECG
87

HR8244A-91-161-Av6HT
ZNF391
Q9UJN7
KDNSDLIKHQRLFSQ
SRSTHLIEHQRTHTG
71

HR7003A-55-179-NHT
ZNF394
Q53GI3
AASPDPETSRLHFRQ
TWEEWERLDPARRDF
125

HR7436A-17-136-NHT
ZNF397
Q8NF99
PEQELILVKVEDNFS
VTLLEDLEREFDDPG
120

HR6874A-291-375-Av6HT
ZNF41
P51814
RIHAGEKSRECDKSN
GKAFFQRSDLFRHLR
85

HR7062-124-478-15
ZNF410
Q86VK4
MLNLTRAGLGSSAEH
PQELLNQGDLTERRT
356

HR7062-129-478-15
ZNF410
Q86VK4
MAGLGSSAEHLVFVQ
PQELLNQGDLTERRT
351

HR7062-150-478-15
ZNF410
Q86VK4
MNDFLSSESTDSSIP
PQELLNQGDLTERRT
330

HR7062-155-478-15
ZNF410
Q86VK4
MSESTDSSIPWFLRV
PQELLNQGDLTERRT
325

HR7338A-520-571-NHT
ZNF416
Q9BWM5
RPYDCGQCGKSFIQK
KSFTQHSGLILHRKS
52

HR6922A-214-292-NHT
ZNF417
Q8TAU3
CGKRTKAFSTKHSVI
SRKSSLIQHQRVHTG
79

HR7936A-544-625-AV6HT
ZNF418
Q8TF45
GKSFHQSSSLLRHQK
RLHTRGKPYECSECG
82

HR8286A-145-234-Av6HT
ZNF420
Q8TAQ5
GKAFRRASHLTQHQS
EKPYKCEECGKAFIR
90

HR7298A-293-344-NHT
ZNF423
Q2M1K9
ADLQCIHCPEVFVDE
EQFSSVEGVYCHLDS
52

HR7298B-1204-1284-Av6HT
ZNF423
Q2M1K9
NQMFDSPAKLLCHLI
FQTELQNHTMSQHAQ
81

HR7298C-136-178-Av6HT
ZNF423
Q2M1K9
LPYPCQFCDKSFIRL
LPFKCTYCSRLFKHK
43

HR7298D-627-684-Av6HT
ZNF423
Q2M1K9
ISNGEYPCNQCDLKF
DFDSQESLLQHLTVH
58

HR7298E-750-803-Av6HT
ZNF423
Q2M1K9
YRCTACNWDFRKEAD
TFSTEVELQCHITTH
54

HR7298F-923-981-Av6HT
ZNF423
Q2M1K9
AEFIKGSHKCNVCSR
RFPSLLTLTEHKVTH
59

HR7298F-928-981-Av6HT
ZNF423
Q2M1K9
GSHKCNVCSRTFFSE
RFPSLLTLTEHKVTH
54

HR8124A-692-742-Av6HT
ZNF425
Q6IV72
RPFQCPECGKGFLQK
GRSFTYVGALKTHIA
51

HR7371A-502-554-NHT
ZNF426
Q9BUY5
KPYECKECGKAFTCS
AYSHPRSLRRHEQIH
53

HR7017A-571-643-NHT
ZNF429
Q86V71
DKAFTHSSNLSSHKK
AFTRSSRLTQHKKIH
73

HR8161A-229-300-Av6HT
ZNF43
P17038
PYTCEECGKVFNWSS
YKCKECAKAFNQSSN
72

HR8378A-511-570-Av6HT
ZNF430
Q9H8G1
TSYKYLECDKAFSQS
LIEQSNSYWRETLQM
60

HR6876A-159-226-NHT
ZNF431
Q8TF32
EGYNELNQCLTTTQS
SFCMLLHLSQHKRIH
68

HR7979A-260-324-Av6HT
ZNF432
O94892
SFICSECGKVFTMKS
NHTGEKSYICSECGK
65

HR7340A-616-673-NHT
ZNF433
Q8N7K0
KPYKCKQCGKAFGCP
SQLQVHGRAHCIDTP
58

HR7145A-271-333-NHT
ZNF434
Q9NX65
SHQSFCARDKACTHI
SRSSYLVRHQRIHTG
63

HR6863A-401-470-NHT
ZNF436
Q9C0F3
ERSDLIKHQRTHTGE
SRSSALIKHKRVHTD
70

HR6993A-498-598-NHT
ZNF438
Q7Z4V0
GFSGIKKPWHRCHVC
GHLKEVHRVVISTEP
101

HR7001A-19-66-NHT
ZNF439
Q8NDP4
VAFKDVAVNFTQEEW
FWNLTSIGKKWKDQN
48

HR7627A-522-574-NHT
ZNF44
P15621
EPYECKECGKAFSSF
AFSRFSYLKTHERTH
53

HR7091A-1-51-NHT
ZNF440
Q8IYI8
DPVAFKDVAVNFTQE
FRNLTSLGKRWKDQN
50

HR6977A-625-693-NHT
ZNF441
Q8N8Z8
SHSSYLRIHERVHTG
AFHCISSFHKHEMTH
69

HR7410A-570-627-NHT
ZNF442
Q9H7R0
KSYECQQCGKAFTRS
SSLHRHKRTHWRDTL
58

HR7294A-14-105-NHT
ZNF444
Q8N0Y2
LALDSPWHRFRRFHL
AVALLEELWGPAASP
92

HR8025A-61-139-Av6HT
ZNF445
P59923
LRYHESSGPLETLSR
EAVALLEELQRDLDG
79

HR8393A-22-126-Av6HT
ZNE446
Q9NWS9
PETARLRFRGFCYQE
LGWITAHVLKQEVLP
105

HR7503A-25-115-NHT
ZNF449
Q6P9G9
DCEVFRQRFRQFQYR
VVSLIEDLQRELEIP
91

HR7588A-340-406-Av6HT
ZNF45
Q02386
SFSYSSHLNIHCRIH
ECGKGFCRASNLLDH
67

HR7276A-252-326-Av6HT
ZNF454
Q8N9P8
AFSVSSSLTYHQKIH
RAHLTKHQNIHSGEK
75

HR7023A-306-367-NHT
ZNF460
Q14592
KPFACSECGKGFYES
QHERIHTGEKPFVCS
62

HR7305A-244-297-NHT
ZNF461
Q8TAF7
KCNECKECWKAFVHC
NYGSELTLHQRIHTG
54

HR8320A-1871-1948-TEV
ZNF462
Q96JM2
SRDLKRDFIILGNGP
KQKYADGAFADFKQE
78

HR8302A-424-504-15
NF467
Q7Z7K2
MAPSGERSFFCPDCG
AQCGRRFSRKSHLGR
82

HR8302A-429-499-15
ZNF467
Q7Z7K2
MRSFFCPDCGRGFSH
RPFACAQCGRRFSRK
72

HR8302B-485-539-15
ZNF467
Q7Z7K2
MRPFACAQCGRRFSR
SSKTNLVRHQAIHTG
56

HR8302C-540-595-TEV
ZNF467
Q7Z7K2
SRPFSCPQCGKSFSR
AWSAPPEVAPPPLFF
56

HR8962C-551-595-TEV
ZNF467
Q7Z7K2
SFSRKTHLVRHQLIH
AWSAPPEVAPPPLFF
45

HR8121A-1-49-Av6HT
ZNF468
Q5VIY5
ALPQGLLTFRDVAIE
DVMLENYRNLVSLDI
48

HR8083A-181-258-Av6HT
ZNF471
Q9BX82
TSDKKSFSKNSMVIK
KQRQHLAQHHRTHTG
78

HR7760A-205-288-Av6HT
ZNF473
Q8WTR7
GEKPYQCSECGKSFS
FSQSTYLWHQKTHTG
84

HR8431-87-906-Av6HT
ZNF474
Q6S9Z5
IPARRPGFRVCYICG
RIFTSDRLLVHQRSC
220

HR6879A-445-517-NHT
ZNF479
Q96JC4
AFSLSSTLTDHKRIH
KWHSSLAKHKIIHTG
73

HR8210A-201-255-Av6HT
ZNF480
Q8WV37
KPYECNEHSKVFRVS
SRNSHLAEHCRIHTG
55

HR7266A-379-438-TEV
ZNF483
Q8TF39
KRQKIHLGDRSQKCS
AALNKDEGNESGEKT
60

HR7735A-326-380-NHT
ZNF484
Q5JVG2
NYYKCSDYGRAPIQK
PQNSNLNIHKKIHTG
55

HR7735B-1-66-Av6HT
ZNF484
Q5JVG2
TKSLESVSFKDVTVD
PKPEVIFSLEQEEPC
65

HR7735B-6-66-Av6HT
ZNF484
Q5JVG2
ESVSFKDVTVDFSRD
PKPEVIFSLEQEEPC
61

HR7735C-259-310-Av6HT
ZNF484
Q5JVG2
VFSPKSHAFAHESIC
GSQRVYAGICTEYEK
52

HR7735C-259-316-Av6HT
ZNF484
Q5JVG2
VFSPKSHAFAHESIC
AGICTEYEKDFSLKS
58

HR8114A-115-182-Av6HT
ZNF485
Q8NCK3
EKGLDWEGRSSTEKN
MNSSSLLNHHKVHAG
68

HR8541A-108-234-Av6HT
ZNF486
Q96H40
ILRKFEKCGHGNLHF
NRSSHLTTHKITHTR
127

HR7094A-456-529-NHT
ZNF490
Q9ULM2
IYFSHLRRHERSHTG
KSLHVHERTHSRQKP
74

HR8126A-332-407-Av6HT
ZNF491
Q8N8L2
CGKAFRSAKYIRIHG
TCSIYIRIHERIHTG
76

HR7429A-33-114-NHT
ZNF496
Q96IT1
GELPSPESSRRLFRR
SWVRAQEPESGEQAV
82

HR7643A-35-118-NHT
ZNF498
Q6NSZ9
DPSPETFRLRFRQFR
EHGPESGKALAAMVE
84

HR7635A-55-136-NHT
ZNF500
O60304
LFCYQEVAGPREALS
VVLVEGLQRKPRKHR
82

HR7681A-163-225-NHT
ZNF501
Q96CX3
KCNECGKAFNQSACL
THTGEKLYKCSECEK
63

HR8192A-151-240-Av6HT
ZNF502
Q8TBZ5
QKKSWKCNECGKTFT
LTQHQRIHTGEKPYK
90

HR7474A-5-630-TEV
ZNF503
Q96F45
PSLSALRSSKHSGGG
PVPVPAATGPYYSPY
626

HR7624A-141-197-NHT
ZNF506
Q5JVG8
QRKIFQCDEYVKFLH
NQSSTRTTYKKIDAG
57

HR7678A-639-723-NHT
ZNF507
Q8TCN5
RPYRCRLCHYTSGNK
KSQLRNHEREQHSLP
85

HR7670A-34-107-15
ZNF510
Q9Y2H8
MQEQQKMNISQASVS
EVIFKLEQGEEPWFS
75

HR7670A-40-102-15
ZNF510
Q9Y2H8
MNISQASVSPKDVTI
CCFKPEVIFKLEQGE
64

HR7670B-515-683-Av6HT
ZNF510
Q9Y2H8
SFQCNQCGKTFGQKS
TLSLYQKIQGEGNPY
169

HR7670B-521-652-Av6HT
ZNF510
Q9Y2H8
CGKTFGQKSNLRIHQ
GQKSNLRIHQRTHSG
132

HR7670B-521-683-Av6HT
ZNF510
Q9Y2H8
CGKTFGQKSNLRIHQ
TLSLYQKIQGEGNPY
163

HR7670C-582-683-Av6HT
ZNF510
Q9Y2H8
ARTSTLRVHQRIHTG
TLSLYQKIQGEGNPY
102

HR7670C-595-683-Av6HT
ZNF510
Q9Y2H8
TGEKPFKCNECGKKF
TLSLYQKIQGEGNPY
89

HR7670D-552-607-Av6HT
ZNF510
Q9Y2H8
SFWRKDHLIQHQKTH
IHTGEKPFKCNECGK
56

HR8051A-493-578-TEV
ZNF512B
Q96KM6
PGGPEEQWQRAIHER
SAKPSDAEASEGGEQ
86

HR7686A-202-256-NHT
ZNF514
Q96K75
KSCKCNECGKSFHFQ
GHISSLIKHQRTHTG
55

HR7203A-240-299-NHT
ZNF516
Q92618
KPELSPGEFPCEVCG
FKEPWFLKNHMKAHG
60

HR8163A-367-458-Av6HT
ZNF517
Q6ZMY9
PHECPVCGRPFRHNS
RLHSGERPYRCRACG
92

HR6938A-228-328-NHT
ZNF518A
Q6AHZ1
RHNEIHYKCGKCHHV
ILKRYKIGASRKTFW
101

HR8175A-141-213-Av6HT
ZNF518B
Q9C0D4
RFSTKDPLQYKKHTL
AIRNDYIVKHTKRVH
73

HR8275A-281-327-Av6HT
ZNF519
Q8TB69
GHQKIHTGEKPYKCK
IHTGEKPFKCKECGK
47

HR8035A-114-170-Av6HT
ZNF521
Q96K83
PGLPYPCQFCDKSFS
KHKRSRDRHIKLHTG
57

HR8035B-928-981-Av6HT
ZNF521
Q96K83
GNYKCNVCSRTFFSE
RFPSLLTLTEHKVTH
54

HR8035C-1253-1292-Av6HT
ZNF521
Q96K83
GGTFKCPVCFTVFVQ
AHGQEDKIYDCTQCP
40

HR8035C-1253-1311-Av6HT
ZNF521
Q96K83
GGTFKCPVCFTVFVQ
FQTELQNHTMTQHSS
59

HR8035D-1177-1247-Av6HT
ZNF521
Q96K83
QVSPMPRISPSQSDE
TFDSPAKLQCHLIEH
71

HR8035D-1187-1247-Av6HT
ZNF521
Q96K83
SQSDEKKTYQCIKCQ
TFDSPAKLQCHLIEH
61

HR8035D-1193-1247-Av6HT
ZNF521
Q96K83
KTYQCIKCQMVFYNE
TFDSPAKLQCHLIEH
55

HR8035E-750-805-Av6HT
ZNF521
Q96K83
KVYRCTSCNWDFRNE
SFGTEVELQCHITTH
56

HR8035E-750-841-Av6HT
ZNF521
Q96K83
KVYRCTSCNWDFRNE
HLREKHCVFETKTPN
92

HR8035F-632-686-Av6HT
ZNF521
Q96K83
GEYICNQCGAKYTSL
EFPNQESLLKHVTIH
55

HR8035G-692-745-Av6HT
ZNF521
Q96K83
TYYICESCDKQFTSV
FDSKVSIQLHLAVKH
54

HR7651A-311-395-NHT
ZNF526
Q8TF50
QRSFSSANRLQAHGR
AHTANPLHRCRCGKT
85

HR8497A-368-478-Av6HT
ZNF527
Q8NB42
SRYAFLVEHQRIHTG
HTGEKPYECIKCGKF
111

HR7761A-499-570-NHT
ZNF528
Q3MIS6
GKVFSRSSNLVCHQK
KAFRGCSGLTAHLAI
72

HR6966A-331-386-NHT
ZNF530
Q6P9A1
SFSHSTNLYRHRSAH
VHTGVRPYECSECGK
56

HR7961A-840-894-Av6HT
ZNF532
Q9HCE3
VGFRCVHCNVVYSDV
KSAPSTHSHAYTQHP
55

HR6910A-112-178-NHT
ZNF536
O15090
GIMSQMSDIEDDARK
DHRAAQKGNLKIHLR
67

HR7987A-333-390-Av6HT
ZNF540
Q8NDQ6
GKAFSVCGQLTRHQK
THAGKKPYECKECGK
58

HR8055A-1071-1130-Av6HT
ZNF541
Q9H0D2
EPHINIGSRFQAEIP
TQDRVTELCNVACSS
60

HR8506A-95-170-Av6HT
ZNF542
Q5EBM4
CTRNVCKECGNLYCH
CNECIKTFNQRAHLT
76

HR7303A-250-315-NHT
ZNF544
Q6NX49
SLNYGSSLCFHGRTF
DECRETCSESLCLVQ
66

HR7708A-449-521-NHT
ZNF546
Q86UE3
AFRLQTELTRHHRTH
SSRYHLTQHYRIHTG
73

HR8224A-347-390-Av6HT
ZNF547
Q8IVP9
TGERPYECSECGKAF
AAKQCSECGKFERYN
44

HR7308A-303-359-NHT
ZNF552
Q9H707
KFFRHKYHLIAHQRV
VHTGQKPYECSECGK
57

HR7586A-351-442-Av6HT
ZNF554
Q86TJ5
PYECQECGRAFTHSS
RTHTGFKPYECSECG
92

HR6864A-534-597-NHT
ZNF555
Q8NEP9
KPYECKECGKVFKWP
VRIHTTEKQYKCNVG
64

HR7560A-285-337-NHT
ZNF556
Q9HAH1
RPYECKQCGKAYCWA
AFGWRSSLHKHARTH
53

HR7484-16-423-TEV
ZNF557
Q8N988
FPASQREGHTEGGEL
CGKSFTSNSYLSVHT
408

HR7484-32-423-TEV
ZNF557
Q8N988
NELLKSWLKGLVTFE
CGKSFTSNSYLSVHT
392

HR7484-TEV
ZNF557
Q8N988
AAVVLPPTAALSSLF
SYLSVHTRMHNRQM*
430

HR7484A-12-94-15
ZNF557
Q8N988
MLSSLFPASQREGHT
ASLGNQVDKPRLISQ
84

HR7484A-16-89-15
ZNF557
Q8N988
MFPASQREGHTEGGE
NCRNLASLGNQVDKP
75

HR7484A-32-89-15
ZNF557
Q8N988
MNELLKSWLKGLVTF
NCRNLASLGNQVDKP
59

HR7484B-344-408-15
ZNF557
Q8N988
MGEKPYTCNECGKSF
HMRTHTGKKPYECNY
66

HR7484B-344-423-15
ZNF557
Q8N988
MGEKPYTCNECGKSF
CGKSFTSNSYLSVHT
81

HR7484B-349-403-15
ZNF557
Q8N988
MTCNECGKSFTNSFS
SSVKKHMRTHTGKKP
56

HR7484B-349-423-15
ZNF557
Q8N988
MTCNECGKSFTNSFS
CGKSFTSNSYLSVHT
76

HR8385A-150-204-Av6HT
ZNF558
Q96NG5
KLNECNQCFKVFSTK
SSRSYLTIHKRIHNG
55

HR7908A-195-264-Av6HT
ZNF559
Q9BR84
PSSSHLRECVRIYGG
FTESSYLTQHLRTHS
70

HR8030A-275-342-Av6HT
ZNF560
Q96MR9
RLILNVQVQRKCTQD
AFTHSTSHAVNVETH
68

HR8284A-153-246-Av6HT
ZNF561
Q8N587
KDTLSVHKEASTGQE
RAVTASSHLKQCVAV
94

HR7120A-315-406-NHT
ZNF562
Q6V9R5
PHKCTECGKAFTRST
RIHTGEKPYECVECG
92

HR7101A-177-267-NHT
ZNF563
Q8TA94
TFSSRRNLRRHMVVQ
YECKQCSKALPDSSS
91

HR7852A-258-333-NHT
ZNF564
Q8TBZ8
CGKAFDRPSLFRIHE
IFPSYVRKHERTHTG
76

HR7421A-165-219-Av6HT
ZNF565
Q8N9K5
KLMECHECGKAFSRG
SRASHLVQHQRIHTG
55

HR6953A-201-290-Av6HT
ZNF566
Q969W8
CKECGKSFRHPSRLT
IHTGEKPYECKECGK
90

HR7055-1-501-TEV
ZNF567
Q8N184
DVMLENYCHLISVGC
TNLNLHQRIHTGEKP
500

HR7055A-1-62-15
ZNF567
Q8N184
MDVMLENYCHLISVG
KAEDFLVKFKEHQEK
62

HR7055A-1-67-15
ZNF567
Q8N184
MDVMLENYCHLISVG
LVKFKEHQEKYSRSV
67

HR7513A-584-636-NHT
ZNF568
Q3ZCX4
KPYECNKCGKAFSQC
AFSQRASLSIHKRGH
53

HR8322A-184-236-Av6HT
ZNF569
Q5MGW4
TPFKCNHCGKGFNQT
AFSHKEKLIKHYKIH
53

HR7036A-222-276-NHT
ZNF57
Q68EA5
KTYKCEQCRMAFNGF
IYPSTFQRHMTTHTG
55

HR8437A-468-518-Av6HT
ZNF570
Q96NI8
KPYECTVCGKAFSYC
KKTFRQHAHLAHHQR
51

HR7898A-556-609-Av6HT
ZNF571
Q7Z3V5
KPYECKECGRAFSRG
FRCPSQLTQHTRLHN
54

HR7069A-130-212-NHT
ZNF572
Q7Z3I7
RPYKCSECWKSFSNS
SNTSHLIIHERTHTG
83

HR7339A-346-414-NHT
ZNF574
Q6ZN55
PSPSSLDQHLGDHSS
FVNLTKFLYHRRTHG
69

HR7766A-185-234-NHT
ZNF575
Q86XF7
AFSFPSKLAAHRLCH
QAFGQRRLLLLHQRS
50

HR7135A-110-164-NHT
ZNF576
Q9H609
PTFPCPDCGKTFGQA
QDFAQEAGLHQHYIR
55

HR7392A-95-172-Av6HT
ZNF580
Q9UK33
PECARVFASPLRLQS
RFQDAAELAQHVRLH
78

HR7332A-85-197-NHT
ZNF581
Q9P0T4
KCYSCPVCSRVFEYM
MEQNTLQKHTRWKHP
113

HR7613A-143-226-NHT
ZNF582
Q96NG8
IIRHEEMPTFDQHAS
SRLIQHENIHSGKKP
84

HR8213A-490-546-Av6HT
ZNF583
Q96ND8
KPYECNVCGKAFSYS
RAHLAHHERIHTMES
57

HR7005A-111-199-NHT
ZNF584
Q8IVC4
EHLKSYRVIQHQDTH
RPFRCPTGRSAFKKS
89

HR7126A-700-769-NHT
ZNF585B
Q52M93
TKKSQLQVHQRIHTG
FVQKSVFSVHQSSHA
70

HR7959A-294-369-Av6HT
ZNF586
Q9NXT0
ECGKSFSLRSNLIHH
AENSSLIKHLRVHTG
76

HR8398-1-385-15
ZNF587
Q96SQ5
MAAAVPRRPTQQGTV
QRVHTGERPYKCGEC
385

HR8398A-13-68-15
ZNF587
Q96SQ5
MGTVTFEDVAVNFSQ
LGCWCGSKDEEAPCK
57

HR8398A-8-73-15
ZNF587
Q96SQ5
MRPTQQGTVTFEDVA
GSKDEEAPCKQRISV
67

HR8398B-85-147-15
ZNF587
Q96SQ5
MGVSPKKAHPCEMCG
AYLHQHQKQHIGEKF
64

HR8398B-90-144-15
ZNF587
Q96SQ5
MKAHPCEMCGLILED
DDTAYLHQHQKQHIG
56

HR7374A-223-283-NHT
ZNF589
Q86UQ0
AFNQKSNLFRQKAVT
THTGEKPYVCGECGR
61

HR7253A-8-134-TEV
ZNF593
O00488
GAHRAHSLARQMKAK
PTEVSTEVPEMDTST
127

HR7622A-658-732-NHT
ZNF594
Q96JF6
GKAFSQRSHLATHQK
MWHTAFLKHQRLHAG
75

HR8535A-211-338-Av6HT
ZNF595
Q8IYB9
RSTSLSKHKRIHTGE
SRSLNEHKNIHTGEK
128

HR7605A-165-247-NHT
ZNF596
Q8TC21
KSYGSHLFDYAFIQN
THCSDLRKHERTHTG
83

HR6958A-339-424-NHT
ZNF597
Q96LX8
KPLQCPDCDMTFPCF
LHLITHKRTHIKNTT
86

HR7504A-200-279-NHT
ZNF599
Q96NL3
TCTECGKGFSKKWAL
KRRFHLTEHQRIHTG
80

HR7536A-401-473-NHT
ZNF605
Q86T29
AFFKKSELIRHQKIH
TQKSSLISHQRTHTG
73

HR7780A-327-407-NHT
ZNF606
Q8WXB4
NQSPSFNEHPRLHVG
TYTAEKPYDYNECGT
81

HR7972A-628-696-Av6HT
ZNF607
Q96SK3
CASYLVRHESVHADG
FRLRSILEVHQRIHI
69

HR7618A-201-256-NHT
ZNF610
Q8N9Z0
SYEYECSEDGEVFRV
SRNSHLVEHWRIHTG
56

HR7693A-602-688-NHT
ZNF611
Q8N823
TFSRRSSLHCHRRLH
AEKPYKCNECGKAFN
87

HR8205A-466-535-Av6HT
ZNF613
Q6PF04
SHKSGLINHQRIHTG
FSHLSCLVYHKGMLH
70

HR7312A-239-311-NHT
ZNF614
Q8N883
KLSRSVLFTKHLKTN
TMKRYLIAHQRTHSG
73

HR7638A-239-293-NHT
ZNF616
Q08AN1
KSYQCDVCGKIFRKN
SKSSHLAVHQRIHTG
55

HR8536A-215-271-Av6HT
ZNF619
Q8N2I2
PYTCKECGKTFRYNS
SHLLQHQKLHGGQRP
57

HR7004A-342-416-Av6HT
ZNF620
Q6ZNG0
GKRLSSNTALTQHQR
SWCGRFILHQKLHTQ
75

HR6865A-260-345-NHT
ZNF621
Q6ZSS3
EKLYKCKECWKAFGC
YGSFVQHQKLHPVEK
86

HR7076A-233-357-Av6HT
ZNF622
Q969S3
MQDAEEEEAEEGPPL
FADFYDFRSSYPDHK
126

HR7076A-233-357-NHT
ZNF622
Q969S3
QDAEEEEAEEGPPLG
FADFYDFRSSYPDHK
125

HR8004A-806-858-Av6HT
ZNF624
Q9P2J8
RPYKCEECGKAFRTN
AFRSSSSLTVHQRIH
53

HR8159A-235-289-Av6HT
ZNF625
Q96I27
KPYECKQCGKAFRSA
GCASSVKIHERTHTG
55

HR8312A-451-505-Av6HT
ZNF626
Q68DY1
KFYKCEECGKAFKCS
NQSSIDTTHERIILE
55

HR7221A-166-234-Av6HT
ZNF627
Q7L945
PYDCKECGETFISLV
EKPYECKQCGKAFSC
69

HR7999A-830-869-Av6HT
ZNF629
Q9UEG4
GQNPKTLVEEKPYLC
AALLLHRSCHPGVSL
40

HR7098A-597-651-NHT
ZNF630
Q2M218
KTPECAESGMTFFWK
CQHVYFTGHQNPYRK
55

HR7646-132-485-Av6HT
ZNF639
Q9UID6
VHTAEDVPIAVEVHA
NERELISHLPVHETT
354

HR7646-158-485-Av6HT
ZNF639
Q9UID6
NSSESLQDQTDEEPP
NERELISHLPVHETT
328

HR7646-168-485-Av6HT
ZNF639
Q9UID6
DEEPPAKLCKILDKS
NERELISHLPVHETT
318

HR7646-24-485-Av6HT
ZNF639
Q9UID6
ISRIADGFNGIFSDH
NERELISHLPVHETT
462

HR7646-80-485-Av6HT
ZNF639
Q9UID6
RNQNYLVPSPVLRIL
NERELISHLPVHETT
406

HR7646-Av6HT
ZNF639
Q9UID6
NEYPKKRKRKTLHPS
ERELISHLPVHETT*
485

HR7646A-406-471-15
ZNF639
Q9UID6
MDDCGKGFSSMLEYC
DLPHKCSDCLMRFGN
67

HR7646A-406-485-15
ZNF639
Q9UID6
MDDCGKGFSSMLEYC
NERELISHLPVHETT
81

HR7646A-411-466-15
ZNF639
Q9UID6
MGFSSMLEYCKHLNS
FKHSADLPHKCSDCL
57

HR7646A-411-485-15
ZNF639
Q9UID6
MGFSSMLEYCKHLNS
NERELISHLPVHETT
76

HR7646B-233-313-Av6HT
ZNF639
Q9UID6
NVCRVCKESFSTNML
SSSSELYLHFQEHSC
81

HR7646B-256-313-Av6HT
ZNF639
Q9UID6
EEDPYICKYCDYKTV
SSSSELYLHFQEHSC
58

HR7646C-372-425-Av6HT
ZNF639
Q9UID6
NFFVCQVCGFRSRLH
GFSSMLEYCKHLNSH
54

HR7646D-202-255-Av6HT
ZNF639
Q9UID6
GLYKCELCEFNSKYF
SFSTNMLLIEHAKLH
54

HR7858A-251-323-Av6HT
ZNF642
Q49AA0
RNTYKLDLINHPTSY
SQSASLSTHQRIHTG
73

HR7770A-52-130-NHT
ZNF645
Q8N7E2
LPIHFCDKCDLPIKI
IVQQCKRTYLSQKSL
79

HR7348A-260-345-NHT
ZNF648
Q5T619
QKPSKPLSPAETRGG
GEKPYPCPDCGKAFV
86

HR7533A-232-314-NHT
ZNF649
Q9BS31
KPHGCSLCGKAFYKR
SRKSLLVVHQRTHTG
83

HR7463A-365-451-NHT
ZNF652
Q9Y209
SFKRSMSLKVHSLQH
GEKPFICETCGKSFT
87

HR8324A-526-605-Av6HT
ZNF653
Q96CK0
REFTCETCGKSFKRK
CGKRFEKLDSVKFHT
80

HR8422A-173-222-15
ZNF655
Q8N720
MGKHEHLNLTEDFQS
TEKSYKCDVCGKIFH
51

HR8422A-173-239-15
ZNF655
Q8N720
MGKHEHLNLTEDFQS
SALTRHQRIHTREKP
68

HR8422A-178-218-15
ZNF655
Q8N720
MLNLTEDFQSSECKE
SIPNTEKSYKCDVCG
42

HR8422A-178-234-15
ZNF655
Q8N720
MLNLTEDFQSSECKE
IFHQSSALTRHQRIH
58

HR8422A-182-234-TEV
ZNF655
Q8N720
EDFQSSECKESLMDL
IFHQSSALTRHQRIH
53

HR8422B-430-491-TEV
ZNF655
Q8N720
HRKEKSYECNEYEGS
AHLVQHQSIHTKENS
62

HR8422B-434-491-TEV
ZNF655
Q8N720
KSYECNEYEGSFSHS
AHLVQHQSIHTKENS
58

HR8422C-372-430-Av6HT
ZNF655
Q8N720
GIHFREKPYTCSECG
AFSQTSCLIQHHKMH
59

HR8422C-372-470-Av6HT
ZNF655
Q8N720
GIHFREKPYTCSECG
EVLTROKAFDCDVWE
99

HR8422C-372-475-Av6HT
ZNF655
Q8N720
GIHFREKPYTCSECG
QKAFDCDVWEKNSSQ
104

HR8422D-378-430-Av6HT
ZNF655
Q8N720
KPYTCSECGKDFRLN
AFSQTSCLIQHHKMH
53

HR7623A-279-349-NHT
ZNF658
Q5TYW1
CDKTTAVEYNKVHMA
SQSSAHIVHQKTQAG
71

HR8538A-1-85-Av6HT
ZNF663
Q8NDT4
YTGEKPDECKENEKA
VLKESCLTPNQRIKT
84

HR6955A-195-249-NHT
ZNF664
Q8N3J9
GEKPYRCCGCGKAFS
AFSQSTSLCIHQRVH
55

HR7621A-171-230-NHT
ZNF667
Q5HYK9
PFECSNCRKAFRQIS
ILHMRIHDGKEILDC
60

HR6925A-83-165-NHT
ZNF670
Q9BS34
TFSQDSNLNLNKKVS
ISLTSVDRHMVTHTS
83

HR7883A-267-337-Av6HT
ZNF671
Q8TAW3
KPHKSTKLVSGFLMG
SQSYDLFKHQTVHTG
71

HR7237A-1-66-NHT
ZNF672
Q499Z4
FATSGAVAAGKPYSC
ARAADLRAHRRTHAG
65

HR7236A-365-437-NHT
ZNF674
Q2M3X9
ASDEKPSPTKHWRTH
SGKSHLSVHHRTHTG
73

HR7578A-1-67-15
ZNF675
Q8TD23
MGLLTFRDVAIEFSL
ITCLEQEKEPLTVKR
67

HR7578A-1-74-15
ZNF675
Q8TD23
MGLLTFRDVAIEFSL
KEPLTVKRHEMVNEP
74

HR7578B-131-199-15
ZNF675
Q8TD23
MGLNQCLPTMQSKMF
SHLTRHERNYTKVNF
70

HR7578B-136-194-15
ZNF675
Q8TD23
MLPTMQSKMFQCDKY
SFCMLSHLTRHERNY
60

HR7578B-137-199-15
ZNF675
Q8TD23
MPTMQSKMFQCDKYV
SHLTRHERNYTKVNF
64

HR7578B-140-194-15
ZNF675
Q8TD23
MQSKMFQCDKYVKVF
SFCMLSHLTRHERNY
56

HR7891A-111-163-Av6HT
ZNF676
Q8N7Q3
KVFQCGKYANVFHKC
SFCMLSHLSQHERIY
53

HR7577A-497-565-NHT
ZNF677
Q86XU0
TERSNLTQHKKIHTG
ALFQSSNIGDHQKSY
69

HR8530A-404-487-Av6HT
ZNF678
Q5SXM1
PYKCEECGKVFKQCS
FSSLTRHKRIHTGEK
84

HR7709A-360-411-NHT
ZNF679
Q8IYX0
AFAFSSTLNTHKRIH
NHKSMHTGEKPYKCE
52

HR8058A-136-204-Av6HT
ZNF680
Q8NEM1
KEGYNELNQCLRTTQ
SFCMLSHLTQHIRIH
69

HR7323A-486-575-NHT
ZNF681
Q96N22
AFNQSSILTTHKRIH
PYQCEECGKAFNOSS
90

HR7060A-141-225-NHT
ZNF682
O95780
PSKIFPYNKCVKVFS
KWFSYLTKHKRIHTG
85

HR7991A-155-211-Av6HT
ZNF684
Q5T5D7
VENAYECSECGKAFK
SRKAHLATHQKIHNG
57

HR7327A-962-1050-Na6HT
ZNF687
Q8N1G0
GWTCGLCHSWFPERD
SSRLILEKHVQVRHG
89

HR7862A-150-239-Av6HT
ZNF689
Q96CS4
ICPDCGCTFPDHOAL
VIHTGEKPYHCPDCG
90

HR8314A-328-397-NHT
ZNF692
Q9BU19
KKHLKEHMKLHSDTR
QKASLNWHQRKHAET
70

HR7296A-298-376-NHT
ZNF695
Q8IW36
CEECGKSFKLFPYLT
NQSSHLTEHRRIHTG
79

HR8310A-158-221-Av6HT
ZNF696
Q9H7X3
CGKAFIHSSHVVRHQ
KPYACADCGKAFGQR
64

HR7368A-352-405-NHT
ZNF697
Q5TEC3
PFACGECGKGFVRRS
SWRSDLVKHQRVHTG
54

HR8203A-585-642-Av6HT
ZNF699
Q32M78
KPFECLECGKAFSCP
AYFRRHVKTHTRENI
58

HR7900-118-686-15
ZNF7
P17097
MQNPGFGDVSDSEVW
NRSSRLTQHQKIHMG
570

HR7900-123-686-15
ZNF7
P17097
MGDVSDSEVWLDSHL
NRSSRLTQHQKIHMG
565

HR7900-176-686-15
ZNF7
P17097
MSSGLDCQPLESQGE
NRSSRLTQHQKIHMG
512

HR7900-181-686-15
ZNF7
P17097
MCQPLESQGESAEGM
NRSSRLTQHQKIHMG
507

HR7900-192-686-15
ZNF7
P17097
MEGMSQRCEECGKGI
NRSSRLTQHQKIHMG
496

HR7900-98-686-Av6HT
ZNF7
P17097
DILKSESYGTVVRIS
NRSSRLTQHQKIHMG
589

HR7900A-632-686-Av6HT
ZNF7
P17097
KLHQCEDCEKIFRWR
NRSSRLTQHQKIHMG
55

HR7964A-390-437-Av6HT
ZNF70
Q9UC06
KPYTCECGKAFRHRS
LCGKSFRGSSHLIRH
48

HR8076A-25-71-Av6HT
ZNF700
Q9H0M5
AFEDVAVNFTQEEWT
FRNLTSIGKKWSDQN
47

HR7819A-251-341-Av6HT
ZNF701
Q9NV72
DFHQKRYLACHRCHT
KCEECDKVFSRKSHL
91

HR6936A-105-196-NHT
ZNF705A
Q6ZN79
TMENSLILEDPFECN
TNCFRLRRHKMTHTG
92

HR7717A-105-196-NHT
ZNF705G
A8MUZ8
TMENSLILEDPFECN
TNCFHLRRHKMTHTG
92

HR7599A-294-364-NHT
ZNF707
Q96C28
GKAFRTKENLSHHQR
GKGFRHLGFFTRHQR
71

HR8522A-127-192-Av6HT
ZNF708
P17019
GLNRCVTTTQSKIVQ
CMLSQLTQHEIIHTG
66

HR8299A-146-232-Av6HT
ZNF709
Q8N972
GKRFSFRSSFRIHER
HTGEKPYKCKECGKT
87

HR7598A-420-489-NHT
ZNF71
Q9NQZ8
SQSAYLIEHQRIHTG
FSRNTNLTRHLRIHT
70

HR7994A-273-347-Av6HT
ZNF710
Q8N1W2
RLDINVQIDDSYLVE
KQPSHLQTHLLTHQG
75

HR7730A-640-700-NHT
ZNF711
Q9Y462
IHKGRKIHQCRHCDF
RQQNELKKHMKTHTG
61

HR7315A-202-251-NHT
ZNF713
Q8N859
SIKHNSDLIYYQGNY
LTDHIHTAEKPSECG
50

HR8420A-149-221-Av6HT
ZNF718
Q3SXZ3
VKVFHKFSNSNKDKI
AFNWSSILTKHKRIH
73

HR7757A-1-62-NHT
ZNF720
Q7Z2F6
GLLTFRDVAIEFSRE
SKPOLITFLEQRKEP
61

HR8490A-143-197-Av6HT
ZNF730
Q6ZMV8
KIFQCDKYVKVFHKF
CILSHLAQHKKIHTG
55

HR8539A-16-91-Av6HT
ZNF738
Q8NE65
GYPGAERNLLEYSYF
DVSKPDLITCLEQGK
76

HR8339A-526-578-Av6HT
ZNF74
Q16587
KPYKCSECGRAFSQN
MFNWSSHLTEHQRLH
53

HR8360A-96-181-Av6HT
ZNF740
Q8NDX6
KIPKNFVCEHCFGAF
SRTDRLLRHKRMCQG
86

HR8176A-34-86-Av6HT
ZNF747
Q9BV97
PGAVSFADVAVYFSR
HLGALGESPTCLPGP
53

HR8509A-408-460-Av6HT
ZNF749
Q43361
RLYKCSECGKAFSLK
AFVRKSHLVQHQKIH
53

HR7901A-1-56-Av6HT
ZNF75A
Q96N20
YFSQEEWELLDPTQK
KVISCLEQGEEPWVQ
55

HR6964-1-358-Av6HT
ZNF76
P36508
ESLGLHTVTLSDGTT
PYTCSTCGKTYRQTS
357

HR6964-1-369-Av6HT
ZNF76
P36508
ESLGLHTVTLSDGTT
RQTSTLAMHKRSAHG
368

HR6964A-173-267-NHT
ZNF76
P36508
GRLYTTAHHLKVHER
RPFQCPFEGCGRSFT
95

HR6964B-161-251-Av6HT
ZNF76
P36508
GDRAFRCGYKGCGRL
KTSGDLQKHVRTHTG
91

HR6964C-227-276-Av6HT
ZNF76
P36508
CPEELCSKAFKTSGD
CGRSFTTSNIRKVHV
50

HR6964C-227-294-Av6HT
ZNF76
P36508
CPEELCSKAFKTSGD
TGERPYTCPEPHCGR
68

HR6964C-232-294-Av6HT
ZNF76
P36508
CSKAFKTSGDLQKHV
TGERPYTCPEPHCGR
63

HR6964C-235-276-Av6HT
ZNF76
P36508
AFKTSGDLQKHVRTH
CGRSFTTSNIRKVHV
42

HR7027A-389-461-NHT
ZNF765
Q7L2R6
SKTFSHKSSLTYHRR
YSFKSNLFIHQKIHT
73

HR7836A-303-379-NHT
ZNF766
Q5HY98
KCGKVYSSSSYLAQH
RHKFSLTVHQRNHNG
77

HR7774A-291-355-NHT
ZNF768
Q9H5H4
CEVCSKAFSQSSDLI
GQKPYKCPHCGKAFG
65

HR8123A-304-359-Av6HT
ZNF77
Q15935
SFSCYSSFRDHVRTH
THSGEKPYECKECGK
56

HR7610A-1-82-NHT
ZNF770
Q6IQ21
AENNLKMLKIQQCVV
VHLERHQLTHSLPFK
80

HR7742A-127-216-NHT
ZNF771
Q7L3S4
RFSAASNLRQHRRRH
PYACADCGTRFAQSS
90

HR7325A-385-458-NHT
ZNF772
Q68DY9
KYFGHKYRLIKHWSV
SHKHVLVQHHRIHTG
74

HR8057A-186-243-Av6HT
ZNF773
Q6PK81
AGKRHYKCSECGKAF
SHKSNLFIHQIVHTG
58

HR7824A-105-159-Av6HT
ZNF775
Q96BV0
GHFVCLDCGKRFSWW
SQKPNLARHQRHHTG
55

HR7510A-199-288-NHT
ZNF776
Q68DI1
IPLQGGKTHYICGES
WYKAHLTEHQRVHTG
90

HR7596A-583-631-NHT
ZNF780A
Q75290
KPFECKECGKAFRLH
ECGKVFSLPTQLNRH
49

HR7666A-735-815-NHT
ZNF780B
Q9Y6R6
GLLTQLAQHQIIHTG
KLVQVRNPLNVRNVG
81

HR7344A-514-586-NHT
ZNF782
Q6ZMW2
AFKLKSGLRKHHRTH
SQKSNLRVHHRTHTG
73

HR8508A-34-122-Av6HT
ZNF783
Q6ZMS7
SYLYSTEITLWTVVA
LLQRRLENVENLLRN
89

HR8227A-257-318-Av6HT
ZNF785
A8K8V0
ACSDCKSRFTYPYLL
RIHTGEKPYPCPDCG
62

HR7825A-407-473-NHT
ZNF786
Q8N393
RLRRLLQVHQHAHGG
GRNFRQRGQLLRHQR
67

HR7915A-65-146-Av6HT
ZNF787
Q6DD87
PYICNECGKSFSHWS
SWSSNLMQHQRIHTG
82

HR8290A-153-225-Av6HT
ZNF789
Q5FWF6
GFLQNLNLIQDQNAQ
RRKAWFDQHQRIHFL
73

HR7454A-424-498-NHT
ZNF79
Q15937
KFFSESSALIRHHII
CSSAFVRHQRLHAGE
75

HR7139A-544-636-NHT
ZNF790
Q6PG37
IWGSQLTRHKKIHTD
FEKAFSSSSHFISLL
93

HR8412A-506-576-Av6HT
ZNF791
Q3KP31
IYPTSFQGHMRMHTG
SVSTSLKKHMRMHNR
71

HR8238A-532-599-15
ZNF792
Q3KQV3
MRPYECSECGKTFRQ
IRERSMENVLLPCSQ
69

HR8238A-532-599-Av6HT
ZNF792
Q3KQV3
RPYECSECGKTFRQR
IRERSMENVLLPCSQ
68

HR7343A-484-570-NHT
ZNF799
Q96GE5
AFSCFQYLSQHRRTH
REKPYECQQCGKAFT
87

HR4794D-252-417-15
ZNF8
P17098
VQDKPYKCTDCGKSF
GKGFRHSSSLAQHQR
166

HR4794D-256-412-15
ZNF8
P17098
PYKCTDCGKSFNHNA
ECNHCGKGFRHSSSL
157

HR4794D-274-417-15
ZNF8
P17098
VHKRIHTGERPYMCK
GKGFRHSSSLAQHQR
144

HR4794D-280-412-15
ZNF8
P17098
TGERPYMCKECGKAF
ECNHCGKGFRHSSSL
133

HR4794E-339-417-15
ZNF8
P17098
KPYECQDCGRAFNQN
GKGFRHSSSLAQHQR
79

HR4794E-344-411-15
ZNF8
P17098
QDCGRAFNQNSSLGR
YECNHCGKGFRHSSS
68

HR7462A-85-152-NHT
ZNF80
P51504
AFPEKVDFVRPMRIH
CGKTFSYHSVFIQHR
68

HR8132A-480-640-Av6HT
ZNF800
Q2TB10
GFDFKQLYCKLCKRQ
AFAKKTYLEHHKKTH
161

HR7014A-407-492-NHT
ZNF808
Q8N4W9
AFNHQSSLARHHILH
TGEKTYKCNECRKTF
86

HR7427A-226-281-NHT
ZNF81
P51508
VFTQNSSYSHHENTH
FPIGEKANTCTEFGK
56

HR8002A-591-645-Av6HT
ZNF816A
Q0VGE8
KPYKCNECGKVFNQK
TGQSTLIHHQAIHGC
55

HR8532A-59-113-Av6HT
ZNF818P
Q6ZRF7
KRSLTNVCGKVLSQN
TQGSRFINHQIVHTG
55

HR7648A-533-610-NHT
ZNF823
P16415
GKAFSWLTCLLRHER
RSLHRHKRTHWKDTL
78

HR7405A-703-761-NHT
ZNF828
Q96JM3
KRGKGKYYCKICCCR
FLLESLLKNHVAAHG
59

HR8193A-154-208-Av6HT
ZNF829
Q3KNS6
KPWECKICGKTFNQN
SRGSLVTRHQRIHTG
55

HR7002A-127-184-15
ZNF83
P51522
MGKIFNKKSNLASHQ
IHTGEKPYKCNECGK
59

HR7002B-70-148-15
ZNF83
P51522
MTYECNFVDSLFTQK
SNLASHQRIHTGEKP
80

HR7002B-74-145-15
ZNF83
P51522
MNFVDSLFTQKEKAN
NKKSNLASHQRIHTG
73

HR7002B-89-145-15
ZNF83
P51522
MGTEHYKCSERGKAF
NKKSNLASHQRIHTG
58

HR8533A-9-176-Av6HT
ZNF833P
Q6ZTB9
PYKCKFCGKAFDNLH
FSSFHSHEGVHTGEK
168

HR8077A-450-518-Av6HT
ZNF835
Q9Y2P0
SQGSSLALHQRTHTG
AFSFSSALIRHQRTH
69

HR8234A-206-287-15
ZNF836
Q6ZNA1
MTQLEKTHIREKPYM
PYQCGVCGKIFRQNS
83

HR8234A-206-287-Av6HT
ZNF836
Q6ZNA1
TQLEKTHIREKPYMC
PYQCGVCGKIFRQNS
82

HR7704A-427-482-NHT
ZNF837
Q96EG3
AFKGRSGLVQHQRAH
LHSGEKPYICRDCGK
56

HR8403A-681-738-Av6HT
ZNF84
P51523
KPYGCSECRKAFSQK
SQLINHQRTHTVKKS
58

HR8489A-197-283-Av6HT
ZNF841
Q6ZN19
RGKPYQCDVCGRIFR
SSSLATHQTVHTGDK
87

HR8361A-897-970-Av6HT
ZNF845
Q96IR2
NQQAHLACHHRIHTG
AKLARHHRIHTGKKH
74

HR7777A-476-525-NHT
ZNF846
Q147U1
KPYACKECGKAFRYS
CGKNFTQSSALAKHL
50

HR7585A-536-595-NHT
ZNF85
Q03923
KPYTCEECGKAFNQS
LTKHKIIHTGEKLQI
60

HR8493A-449-519-Av6HT
ZNF852
B4DLD7
SYNSSLMVHQRTHTG
SQRSTFNHHQRTHAG
71

HR8177-500-555-Av6HT
ZNF880
Q6PD84
VFSHNSHLARHRQIH
IHTGEKPYRCHECGK
56

HR6923A-519-589-NHT
ZNF90
Q03938
KRSSVLSKHKIIHTG
NLSSDLNTHKRIHIG
71

HR8498A-486-572-Av6HT
ZNF98
A6NK75
GEKPYKCEECGKAFN
IAKISKYKRNCAGEK
87

HR8425A-706-753-Av6HT
ZNF99
A8MXY4
AFNNSSTLRKHEIIH
IHTGKKPYKCEECGK
48

HR7451A-925-1258-Av6HT
ZNFX1
Q9P2E3
LDLSSRWQLYRLWLQ
SKIIHTLRENNQIGP
334

HR6880A-166-356-NHT
ZRSR2
Q15696
EKDRANCPFYSKTGA
ANRDIYLSPDRTGSS
191

HR7933A-24-120-Av6HT
ZSCAN1
Q8NBBT
ADPGPASPRDTEAQR
CREAASLVEDLTQMC
97

HR7806A-1-70-NHT
ZSCAN10
Q96SZ4
GPRASLSRLRELCGH
DGEEVVLLLEGIHRE
69

HR8495A-9-132-Av6HT
ZSCAN12
O43309
AHMDQDEPLEVKIEE
VTVLEDLERELDEPG
124

HR7081A-224-291-TEV
ZSCAN16
Q9H4T2
GRSEWQQRERRRYKC
SHLIGHHRVHTGVKP
68

HR7530A-36-127-NHT
ZSCAN21
Q9Y5A6
KYLPSLEMFRQRFRQ
AEEAVTLLEDLEREL
92

HR7904A-40-135-Av6HT
ZSCAN22
P10073
DHIAHSEAARLRFRH
AVLVEDLTQVLDKRG
96

HR7247A-37-133-NHT
ZSCAN23
Q3MJ62
SRNNPHTREIFRRRF
AVTVLEDLERELDDP
97

HR8429A-9-104-Av6HT
ZSCAN29
Q8IWY8
ENGTNSETFRQRFRR
VTLVEDLEREPGRPR
96

HR6932A-12-134-NHT
ZSCAN80
Q86W11
APEEQEGLLVVKVEE
VTMLEELEKELEEPR
123

HR7089A-35-123-Av6HT
ZSCAN4
Q8NAM6
REEGISEFSRMVLNS
KSSGKNLERFIEDLT
89

HR7089A-35-130-NHT
ZSCAN4
Q8NAM6
REEGISEFSRMVLNS
ERFIEDLTDDSINPP
96

HR7089A-46-123-Av6HT
ZSCAN4
Q8NAM6
VLNSFQDSNNSYARQ
KSSGKNLERFIEDLT
78

HR7089A-46-130-Av6HT
ZSCAN4
Q8NAM6
VLNSFQDSNNSYARQ
ERPIEDLTDDSINPP
85

HR6950A-39-129-NHT
ZSCAN5A
Q9BUG6
DPEISHVNFRMFSCP
LEDLLRNNRRPKKWS
91

HR8432A-35-142-Av6HT
ZSCAN5B
A6NJL1
NHDRNPETWHMNFRM
WSIVNLLGKEYLMLN
108

HR7759A-37-130-NHT
ZSCAN5C
A6NGD5
DSDPETCHVNFRMFS
EDLLRNNRRPKKWSV
94

HR8021A-314-557-Av6HT
ZUFSP
Q96AP4
DGKTKTSGIIEALHR
LKHKQYDILAVEGAL
244

HR7812A-358-413-NHT
ZXDA
P98168
NSFKCEVCEESFPTQ
TFITVSALFSHNRAH
56

HR7168A-360-417-NHT
ZXDB
P98169
QENSFKCEVCEESFP
TFITVSALFSHNRAH
58

HR7131A-652-715-TEV
ZZZ3
Q8IYH5
NQLWTVEEQKKLEQL
KYFIKLTKAGIPVPG
64

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The foregoing examples and description of the preferred embodiments should be taken as illustrating, rather than as limiting the present invention as defined by the claims. As will be readily appreciated, numerous variations and combinations of the features set forth above can be utilized without departing from the present invention as set forth in the claims. Such variations are not regarded as a departure from the scope of the invention, and all such variations are intended to be included within the scope of the following claims. All references cited herein are incorporated herein in their entireties.

TRANSCRIPT OPTIMIZED EXPRESSION ENHANCEMENT FOR HIGH-LEVEL PRODUCTION OF PROTEINS AND PROTEIN DOMAINS

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