Claims
- 1. A composition of matter for the transdermal administration of a therapeutic agent comprising a compound selected from the group consisting of N-(2,5-disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidines and pharmaceutically acceptable salts thereof, in a carrier effective to permit sustained release of the compound at a therapeutically effective rate during an administration period.
- 2. A composition according to claim 1 further comprising a permeation enhancing amount of a permeation enhancer.
- 3. A composition according to claim 2 wherein said permeation enhancer is selected from the group consisting of lauryl pyroglutamate, fatty acids, monoglycerides of fatty acids including but not limited to glycerol monolaurate, glycerol monooleate, glycerol monocaprate, glycerol monocaprylate, or glycerol monolinoleate; lactate esters of fatty acids including but not limited to lauryl lactate, cetyl lactate, and myristyl lactate; acyl lactylates including but not limited to caproyl lactylic acid; esters of fatty acids having from about 10 to about 20 carbon atoms, including, but not limited to, isopropyl myristate, and ethyl palmitate; alkyl laurates such as methyl laurate; dimethyl lauramide; lauryl acetate; monoalkyl ethers of polyethyleneglycol and their alkyl or aryl carboxylic acid esters and carboxymethyl ethers such as polyethylene glycol-4 lauryl ether (Laureth-4) and polyethylene glycol-2 lauryl ether (Laureth-2); polyethylene glycol monolaurate; myristyl sarcosine; Myreth-3; and lower C1-4 alcohols such as isopropanol and ethanol, all alone or in combination of two or more.
- 4. A composition according to claim 3 wherein said permeation enhancer is lauryl pyroglutamate.
- 5. A composition according to claim 2 further comprising a polymeric carrier.
- 6. A composition according to claim 5 comprising:
(a) 1 to 30 weight % of said therapeutic agent; (b) 0 to 50 weight % of a permeation enhancer; and (c) 30 to 90 weight % of a polymeric carrier.
- 7. A composition according to claim 5 comprising:
(a) 1 to 25 weight % of said therapeutic agent; (b) 1 to 30 weight % of a permeation enhancer; and (c) 30 to 90 weight % of a polymeric carrier.
- 8. A composition according to claim 5 comprising:
(a) 1 to 15% by weight N-2(-chloro-5-(methylthio)phenyl)-N′(3-methylthio)phenyl)-N′-methyl guanidine. (b) 4 to 20% by weight lauryl pyroglutamate (c) 30 to 90% by weight of a polymeric carrier.
- 9. A device for the transdermal administration of a therapeutic agent at a therapeutically effective rate, comprising:
(a) a reservoir comprising a therapeutic agent comprising a compound selected from the group consisting of N-(2,5-disubstituted phenyl)-N′-(3-substituted phenyl)-N′-methyl guanidines and pharmaceutically acceptable salts thereof; (b) a backing behind the body distal surface of the reservoir; and (c) means for maintaining the reservoir in therapeutic agent transmitting relation with a body surface or membrane, wherein a therapeutically effective amount of guanidine is delivered at a therapeutically effective rate during an administration period in order to achieve and maintain therapeutic blood or plasma levels throughout a substantial portion of the administration period.
- 10. A device according to claim 9 further comprising a permeation enhancing amount of a permeation enhancer.
- 11. A device according to claim 10 wherein said permeation enhancer is selected from the group consisting of lauryl pyroglutamate, fatty acids, monoglycerides of fatty acids including but not limited to glycerol monolaurate, glycerol monooleate, glycerol monocaprate, glycerol monocaprylate, or glycerol monolinoleate; lactate esters of fatty acids including but not limited to lauryl lactate, cetyl lactate, and myristyl lactate; acyl lactylates including but not limited to caproyl lactylic acid; esters of fatty acids having from about 10 to about 20 carbon atoms, including, but not limited to, isopropyl myristate, and ethyl palmitate; alkyl laurates such as methyl laurate; dimethyl lauramide; lauryl acetate; monoalkyl ethers of polyethyleneglycol and their alkyl or aryl carboxylic acid esters and carboxymethyl ethers such as polyethylene glycol-4 lauryl ether (Laureth-4) and polyethylene glycol-2 lauryl ether (Laureth-2); polyethylene glycol monolaurate; myristyl sarcosine; Myreth-3; and lower C1-4 alcohols such as isopropanol and ethanol, all alone or in combination of two or more.
- 12. A device according to claim 10 further comprising a polymeric carrier.
- 13. A device according to claim 10 wherein said permeation enhancer is lauryl pyroglutamate.
- 14. A device according to claim 12 wherein the reservoir comprises:
(a) 1 to 30% by weight of said therapeutic agent; (c) 0 to 50% by weight of said permeation enhancer; and (d) 30 to 90 by weight of said polymeric carrier.
- 15. A device according to claim 12 wherein the reservoir comprises:
(a) 1 to 25% by weight of said therapeutic agent; (c) 1 to 30% by weight of said permeation enhancer; and (d) 30 to 90 by weight of said polymeric carrier.
- 16. A device according to claim 12 wherein the reservoir comprises:
(a) 1 to 15% by weight N-2(-chloro-5-(methylthio)phenyl)-N′-(3-methylthio)phenyl)-N′-methyl guanidine. (b) 4 to-20% by weight lauryl pyroglutamate (c) 30 to 90% by weight of a polymeric carrier.
- 17. A device according to claim 9 wherein the reservoir comprises a pressure sensitive adhesive which further acts as said means for maintaining the reservoir in guanidine transmitting relation with a body surface or membrane.
- 18. A method for treating an individual in need of guanidine therapy comprising transdermally administering guanidine and simultaneously coadministering a permeation enhancer to the individual wherein a therapeutically effective amount of guanidine is delivered at a therapeutically effective rate during an administration period in order to achieve and maintain therapeutic blood or plasma levels of guanidine throughout a substantial portion of the administration period.
- 19. A method according to claim 18 wherein 1-6 mg/day of guanidine are administered.
- 20. A method according to claim 18 wherein 2-3 mg/day of guanidine are administered.
- 21. A method according to claim 18 wherein guanidine is administered at a rate of 20-5500 μg/hr.
- 22. A method according to claim 18 wherein guanidine is administered at a rate of 60-600 μg/hr.
- 23. A method according to claim 18 wherein the administration period is 24-72 hours.
- 24. A method according to claim 18 wherein a pharmaceutically acceptable salt of guanidine is administered.
- 25. A method according to claim 18 wherein said permeation enhancer is selected from the group consisting of lauryl pyroglutamate, fatty acids, monoglycerides of fatty acids including but not limited to glycerol monolaurate, glycerol monooleate, glycerol monocaprate, glycerol monocaprylate, or glycerol monolinoleate; lactate esters of fatty acids including but not limited to lauryl lactate, cetyl lactate, and myristyl lactate; acyl lactylates including but not limited to caproyl lactylic acid; esters of fatty acids having from about 10 to about 20 carbon atoms, including, but not limited to, isopropyl myristate, and ethyl palmitate; alkyl laurates such as methyl laurate; dimethyl lauramide; lauryl acetate; monoalkyl ethers of polyethyleneglycol and their alkyl or aryl carboxylic acid esters and carboxymethyl ethers such as polyethylene glycol-4 lauryl ether (Laureth-4) and polyethylene glycol-2 lauryl ether (Laureth-2); polyethylene glycol monolaurate; myristyl sarcosine; Myreth-3; and lower C1-4 alcohols such as isopropanol and ethanol, all alone or in combination of two or more.
RELATED CASES
[0001] This case is a non-provisional application claiming priority under 35 U.S.C. §119 from U.S. provisional application No. 60/153,996 filed on Sep. 15, 1999.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60153996 |
Sep 1999 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09658649 |
Sep 2000 |
US |
Child |
10412104 |
Apr 2003 |
US |