Claims
- 1. A method of coating the surface of one or more microprojections of a microprojection array comprising the steps of:
providing a microprojection array comprised of one or more microprojections; treating the surface of one or more of said microprojections of said microprojection array with a method selected from group consisting of chemical pre-etching, plasma treatment, heat treating, rinsing with an alkaline detergent and rinsing with a wetting agent; providing a coating formulation comprising an active agent; applying said coating formulation to said treated surfaces of said one or more microprojections; and drying said coating formulation onto said surfaces to form a coating.
- 2. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said coating formulation contains a pharmacologically effective dose of said agent.
- 3. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said step of treating comprises chemical pre-etching.
- 4. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said step of treating comprises plasma treatment.
- 5. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said step of treating comprises heat treating.
- 6. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said step of treating comprises rinsing at least one surface of one or more microprojections with an alkaline detergent.
- 7. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said step of treating comprises rinsing at least one surface of one or more microprojections with a wetting agent.
- 8. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 7 wherein said wetting agent comprises a surfactant.
- 9. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 8 wherein said surfactant comprises a surfactant selected from the group consisting of sodium dodecyl sulfate, cetyl pyridinium chloride, TMAC, benzalkonium chloride, tweens, sorbitans, and laureths.
- 10. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said wetting agent is present in a concentration at or above the critical micelle concentration.
- 11. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said wetting agent comprises a wetting agent selected from the group consisting of HEC, HPC, HPMC, MC, HEMC, EHEC and pluronics.
- 12. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said wetting agent comprises a wetting agent selected from the group consisting of proteins and peptides.
- 13. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 9 wherein said tweens comprise a tween selected from the group consisting of tween 20 and tween 80.
- 14. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 1 wherein said coating formulation has a viscosity from about 3 centipoise to about 200 centipoise and said coating formulation has a contact angle of less than about 100 degrees.
- 15. A method of coating the surface of one or more microprojections of a microprojection array comprising the steps of:
providing a microprojection array comprised of one or more microprojections; providing a coating formulation comprising an active agent and a wetting agent; applying said coating formulation to said surfaces of said one or more microprojections; and drying said coating formulation onto said surfaces to form a coating.
- 16. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 15 wherein said coating formulation contains a pharmacologically effective dose of said agent.
- 17. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 7 wherein said wetting agent comprises a surfactant.
- 18. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 17 wherein said surfactant comprises a surfactant selected from the group consisting of sodium dodecyl sulfate, cetyl pyridinium chloride, TMAC, benzalkonium chloride, tweens, sorbitans, and laureths.
- 19. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 15 wherein said wetting agent is present in a concentration at or above the critical micelle concentration.
- 20. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 15 wherein said wetting agent comprises a wetting agent selected from the group consisting of HEC, HPC, HPMC, MC, HEMC, EHEC and pluronics.
- 21. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 15 wherein said wetting agent comprises a wetting agent selected from the group consisting of proteins and peptides.
- 22. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 18 wherein said tweens comprise a tween selected from the group consisting of tween 20 and tween 80.
- 23. The method of coating the surface of one or more microprojections of a microprojection array as disclosed in claim 15 wherein said coating formulation has a viscosity from about 3 centipoise to about 200 centipoise and said coating formulation has a contact angle of less than about 100 degrees.
TECHNICAL FIELD
[0001] This application claims the benefit of provisional Application No. 60/392,609, filed Jun. 29, 2002, which is incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60392609 |
Jun 2002 |
US |