Claims
- 1. A transdermal therapeutic system comprising:
a detachable protective layer; a pressure-sensitive adhesive reservoir layer comprising at least one active substance; and a backing layer comprising unidirectional elastic material having an elasticity of at least 20%, wherein the material is a woven fabric.
- 2. The transdermal therapeutic system of claim 1 wherein the backing layer is a coating of pressure-sensitive adhesive.
- 3. The transdermal therapeutic system of claim 2 further comprising a separating layer between the reservoir layer and the backing layer.
- 4. The transdermal therapeutic system of claim 1 wherein the system is a patch.
- 5. The transdermal therapeutic system of claim 1 wherein the backing layer comprises longitudinally elastic material.
- 6. The transdermal therapeutic system of claim 1 wherein the elasticity of the backing layer is less than 150%.
- 7. The transdermal therapeutic system of claim 1 wherein the backing layer projects beyond the reservoir layer on all sides.
- 8. The transdermal therapeutic system of claim 1 wherein the elastic material of the backing layer has an elasticity of between 20-80%.
- 9. The transdermal therapeutic system of claim 8 wherein the elastic material of the backing layer has an elasticity of between 40-70%.
- 10. The transdermal therapeutic system of claim 9 wherein the elastic material of the backing layer has an elasticity of between 44-56%.
- 11. The transdermal therapeutic system of claim 1 wherein the material comprising the backing layer is more than 90% microbially nondegradable.
- 12. The transdermal therapeutic system of claim 11 wherein the material comprising the backing layer is more than 99% microbially nondegradable.
- 13. The transdermal therapeutic system of claim 1 wherein the backing layer comprises a material selected from the group consisting of a polyethylene, a polypropylene and a polyester.
- 14. The transdermal therapeutic system of claim 13 wherein the backing layer comprises a polyalkylene terephthalate.
- 15. The transdermal therapeutic system of claim 14 wherein the backing material is a polyterephthalic diester.
- 16. The transdermal therapeutic system of claim 15 wherein the backing material is a polyterephthalic acid diol ester obtainable by the reaction of a starting material selected from the group consisting of ethylene glycol, 1,4-butanediol, 1,4-dihydroxymethylcyclohexane, terephthalic acid, isophthalic acid, adipic acid, azelaic acid, sebacic acid, dimethyl terephthalate, dimethyl azelate, dimethyl sebacate, bisphenol A diglycidyl ether, n-decane-1,10-dicarboxylic acid, polyethylene glycol, and polybutylene glycol.
- 17. The transdermal therapeutic system of claim 1 wherein the reservoir layer comprises at least one active substance selected from the group consisting of a psychopharmaceutical, an analgesic and a hormone.
- 18. The transdermal therapeutic system of claim 17 wherein the active ingredient is selected from the group consisting of oestriol, buprenorphine and a parasympathomimetic.
- 19. The transdermal therapeutic system of claim 18, wherein the parasympathomimetic active ingredient is selected from the group consisting of choline esters, alkaloids and choline esterase inhibitors.
- 20. The transdermal therapeutic system of claim 19, wherein the choline esters are selected from the group consisting of acetylcholine, bethanechol, carbachol and methacholine.
- 21. The transdermal therapeutic system of claim 19, wherein the alkaloids are selected from the group consisting of arecholine and its derivatives and pilocarpine.
- 22. The transdermal therapeutic system of claim 19, wherein the choline esterase inhibitors are selected from the group consisting of demacarium bromide, distigmine bromide, neostigmine, physostigmine, pyridostigmine bromide and galanthamine.
- 23. The transdermal therapeutic system of claim 19 wherein the parasympathomimetic active ingredients are used in combination with each other.
- 24. The transdermal therapeutic system of claim 1 wherein the backing layer facing outwardly has a differentiated marking element.
- 25. The transdermal therapeutic system of claim 24 wherein the marking element is a colored marking.
- 26. The transdermal therapeutic system of claim 25 wherein the colored marking is in strip form or a colored thread.
- 27. The transdermal therapeutic system of claim 24 wherein the marking element has an elasticity of between −20% to +20% relative to the elasticity of the remaining portion of the backing layer.
- 28. The transdermal therapeutic system of claim 1 wherein the backing layer has a water vapor permeability of at least 0.1 g/m2/h.
- 29. The transdermal therapeutic system of claim 28 wherein the backing layer has a water vapor permeability of between 1 to 20 g/m2/h.
- 30. The transdermal therapeutic system of claim 1 wherein the backing layer has a number of warp threads in the range from 300 to 350 per 10 cm of unextended fabric.
- 31. The transdermal therapeutic system of claim 1 wherein the backing layer comprises a material selected from the group consisting of a woven fabric, a nonwoven fabric and a film.
- 32. The transdermal therapeutic system of claim 31 wherein the fabric or film comprises pores having a size less than or equal to 400 μm2 embracing an areal proportion of between 10% and 50% of said fabric or film.
- 33. The transdermal therapeutic system of claim 31 wherein the fabric has a number of warp threads in the range of 300 to 350 per cm of unextended fabric and a number of weft threads in the range from 100 to 140 per 10 cm of unextended fabric.
- 34. The transdermal therapeutic system of claim 33 wherein the number of weft threads is in the range from 120 to 130.
Priority Claims (1)
Number |
Date |
Country |
Kind |
197 38 855.8 |
Sep 1997 |
DE |
|
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation application of application Ser. No. 09/486,266, filed May 3, 2000, which is the National Stage of International Application No. PCT/EP98/05321 filed Aug. 21, 1998.
Continuations (1)
|
Number |
Date |
Country |
Parent |
09486266 |
May 2000 |
US |
Child |
10891942 |
Jul 2004 |
US |