Claims
- 1. A method for the treatment of vasodilations in the brain or feelings of ill-health caused by paroxysmal dilation of the blood vessels in the brain which comprises transdermally administering to a human in need of such treatment an effective amount of a pharmaceutical composition comprising at least one skin-compatible auxiliary agent and, as the active substance, pentetrazole (6,7,8,9-tetrahydro-5H-tetrazole(1,5-a)azepine).
- 2. The method according to claim 1, wherein the transdermal administration is effected by applying to the skin of the human a transdermal therapeutic system comprising said pharmaceutical composition.
- 3. The method according to claim 1, wherein the human is suffering from a migraine.
- 4. The method according to claim 2, wherein the human is suffering from a migraine.
- 5. The method according to claim 1, wherein the human is suffering from feelings of ill-health caused by excessive alcohol consumption.
- 6. The method according to claim 2, wherein the human is suffering from feelings of ill-health caused by excessive alcohol consumption.
- 7. The method according to claim 1, wherein said pharmaceutical composition is in the form of an ointment.
- 8. The method according to claim 1, wherein the pharmaceutical composition is in the form of a cream.
- 9. The method according to claim 1, wherein the pharmaceutical composition is in the form of a lotion.
- 10. The method according to claim 2, wherein the transdermal therapeutic system is in the form of a plaster.
- 11. The method according to claim 10, wherein the plaster comprises an impermeable backing layer, an active substance, an active substance reservoir, a pressure-sensitive adhesive and, optionally, a removable protective layer, wherein
- the active substance reservoir is attached to the backing layer;
- the active substance reservoir comprises a polymer matrix, and,
- where no other control mechanism is present, a membrane controlling the release of said active substance; and
- the pressure-sensitive adhesive secures the plaster to the skin.
- 12. The method according to claim 1, wherein the pharmaceutical composition contains 0.1 to 50% by weight of said active substance.
- 13. The method according to claim 12, wherein the pharmaceutical composition contains 3 to 25% by weight of active substance.
- 14. The method according to claim 13 wherein the pharmaceutical composition comprises 5 to 15% by weight of active substance.
Priority Claims (1)
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42 29 230 |
Sep 1992 |
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Parent Case Info
This application is a divisional of application Ser. No. 08/392,890, filed Mar. 1, 1995, file as application No. PCT/EP93/02183, Aug. 6, 1993.
US Referenced Citations (6)
Foreign Referenced Citations (3)
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Date |
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0 271 489 |
Jun 1988 |
EPX |
3 315 272 |
Mar 1986 |
DEX |
4 110 027 |
Oct 1992 |
DEX |
Non-Patent Literature Citations (3)
Entry |
Keshary et al., Drug Development and Industrial Pharmacy, vol. 11 pp. 1213-1253 (1985). |
Heilmann, Therapeutische Systeme, Konzept und Realisation programmierter Arzneiverabreuichung, 4th Edition 1984 pp. 26-39. |
Erickson, Advances in Experimental Medicine and Biology,k vol. 126 Biological Effects of Alcohol (1980) pp. 551-559. |
Divisions (1)
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392890 |
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