Claims
- 1. A transdermal therapeutic system, comprising:
- a) a top coating which is impermeable to water, penetration enhancer and active ingredient, and
- b) an adhesive matrix, adhered to the top coating comprising
- b1) an active ingredient,
- b2) 0.1 to 40% by weight relative to the total weight of the matrix of a vinylpyrrolidone-vinylacetate copolymer as crystallization inhibitor, and
- b3) a skin contact adhesive.
- 2. The system according to claim 1, wherein the active ingredient, b1) is asteroid hormone.
- 3. The system of claims 1, wherein the active ingredient, b1), is a steroid hormone, a corticoid, an ergoline group-containing compound, an antihypertensive compound, an anticoagulant compound, a psychopharmacological agent compound, an organic nitro compound, a beta blocker compound, a carotenoid compound, a .beta.-carboline group-containing compound, scopalamine or a mixture thereof.
- 4. The system of claim 1, wherein the adhesive matrix, b), further comprises a penetration enhancer.
- 5. The system of claim 1, further comprising a removable protective layer, c), over the adhesive matrix, b).
- 6. The system of claim 1, wherein the active ingredient, b1), is incorporated in the adhesive matrix, b), in a concentration of 0.1 to 10% by weight relative to the total weight of the matrix.
- 7. The system of claim 1, wherein the top coating, a), is a film of polyvinyl chloride, polyvinylidene chloride, ethylene/vinyl acetate copolymer, polyethylene, polyester, copolymers thereof or coextrudates thereof.
- 8. The system of claim 7, wherein the top coating has a thickness of 10-100.mu.m.
- 9. The system of claim 1, wherein the adhesive matrix, b), has a thickness of 20 to 500.mu.m and a surface opposite the surface adhered to the top coating with a surface area of 5 to 100 cm.sup.2.
- 10. The system of claim 1, wherein the skin contact adhesive is a polyacrylate.
Priority Claims (2)
Number |
Date |
Country |
Kind |
41 36 057.5 |
Oct 1991 |
DEX |
|
42 10 711.3 |
Mar 1992 |
DEX |
|
Parent Case Info
This is a continuation, of application Ser. No. 08/232/09 filed Apr. 29 1994 now abandoned.
US Referenced Citations (2)
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Continuations (1)
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Number |
Date |
Country |
Parent |
232099 |
Apr 1994 |
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