This invention relates to an improved transfer set for transferring fluid from a first container, such as a conventional vial having a pierceable closure or stopper, and a second container, such as a syringe.
It is conventional to store drugs, vaccines, medicaments and solutions in a sealed vial or other container for later use. Drugs, vaccines, medicaments and solutions may be stored in a dry or powdered form to increase the shelf life and reduce inventory space. Such dry or powdered materials may be stored in a conventional sealed vial having a pierceable closure, such as an elastomeric stopper, and reconstituted in liquid form for later use, such as administration to a patient, by adding a diluent or solvent for example. Alternatively, such drugs, vaccines, medicaments and solutions may be stored in a vial in a liquid or even a gaseous form. A conventional vial for storing such materials in liquid, dry or gaseous form includes an open end, a radial rim portion surrounding the open end and a reduced diameter neck portion adjacent the rim portion. The vial is conventionally sealed with an elastomeric stopper or other pierceable closure which generally includes a tubular portion inserted in the open end in the neck of the vial and a planar rim portion which overlies the vial rim. The stopper is conventionally secured to the vial with a thin malleable metal cap, such as aluminum. Because aluminum is malleable, the collar accommodates the buildup of tolerances of the dimensions on the stopper and vial rim.
Recently, various vial transfer sets have been proposed for transferring fluid between a vial and a conventional syringe, wherein the transfer set is mounted on the vial for later use. The transfer set may include a piercing member, such as a needle cannula, generally telescopically mounted in a tubular fluid transfer member mounted on the open end of the vial. The transfer set may be enclosed by a cup-shaped closure or housing having a radial flange secured to the vial by a malleable metal or plastic collar.
Transfer sets have been utilized, for example, to transfer fluid from a vial to a syringe, such as a reconstituted dry or powdered drug, vaccine or medicament by adding a diluent or solvent in the syringe. The reconstituted drug may then be withdrawn from the vial by the syringe. The inner surface of the transfer set may be part of the fluid path and the aluminum collar or ring may bring aluminum particles into the sterile room where the drug, vaccine or medicament is added to the vial or into the drug path contaminating the drug, vaccine or medicament. There have been attempts to reduce this problem by applying a protective coating to the aluminum cap or collar. Finally, the prior art also includes snap-on cup-shaped plastic caps or collars having radially inwardly projecting end portion which is snapped over the rim of the vial. Snap-on collars, however, do not assure adequate sealing of the vial or fully accommodate the tolerances of standard vials and stoppers, as required.
The prior art also discloses plastic transfer sets for vials. However, such plastic transfer sets are relatively expensive having several interfitting parts and are difficult to manufacture and use. The need therefore remains for a transfer set for vials or other containers which may be utilized with conventional containers used by the medical industry, which assures sealing of the container and which achieves a good level of cleanliness, without particles or dust which may contaminate the drugs, vaccines or medicaments, the transfer set or the clean room, and which does not expose the health care worker to sharp metal edges. The need also remains for a transfer set which may be easily secured to a vial or other container and which is relatively simple in construction and easy to use.
The improved embodiments of the transfer set of this invention may be utilized, for example, to transfer fluid between a conventional vial having a pierceable closure or stopper and a conventional syringe having a Luer threaded connector without a needle cannula. However, the transfer set of this invention is universal in that it can be utilized to transfer fluid between any container having a pierceable closure and a second container. The components of the transfer set may be formed of polymers, preferably a polymer which may be sterilized for medical applications. In the most preferred embodiments of the transfer set of this invention, where the collar portion of the tubular housing member is radially deformed into the reduced diameter neck portion of the vial as described herein, the tubular housing member is preferably formed of a polymer which may be permanently deformed radially to secure the transfer set to the vial or container, yet sufficiently rigid to retain its shape following deformation and resistant to creep to maintain a good seal between the container and the transfer set, thereby avoiding contamination.
The embodiments of the improved transfer set of this invention include a tubular housing member having a proximal end adapted to be attached to the first container open end and an open distal end. For ease of description only, the term “proximal” is used herein to designate the portions of the transfer set closest to the first container or vial to which the transfer set may be attached and the term “distal” is used herein to refer to the portions or the components furthest from the first container. A cap is releasably attached over the open distal end of the tubular housing member, sealing the open distal end. The transfer set further includes a piercing member which is telescopically supported in the tubular housing member having a proximal piercing end adapted to pierce the closure in the open end of the container and a distal end. In the preferred embodiments of the transfer set of this invention, the housing includes an inner tubular portion and a spaced outer tubular portion adjacent the distal end. The inner tubular portion transfers fluid between the first and second containers and preferably includes a Luer thread to threadably receive the tip portion of a needleless syringe, for example, and the outer tubular portion receives a cap or closure which seals the assembly. In one preferred embodiment, the housing or body is generally “H” shaped in crosssection, wherein the inner tubular portion is integrally formed with the spaced outer tubular portion and the inner and outer tubular portions are integrally connected by an integral radial web portion. In this embodiment, the proximal end of the inner tubular portion sealingly engages the pierceable closure in the open end of the first container and the outer tubular portion includes a radial portion sealingly engaging the pierceable closure which is integrally formed with a tubular collar portion. The proximal end of the inner tubular portion includes a sharp end and the radial portion of the outer tubular portion may include one or a plurality of annular sealing rings. Fluid is thus transmitted between the first and second containers through the inner tubular portion.
In another preferred embodiment of the transfer set of this invention, the body is “Y” shaped or bell-shaped in crosssection including a central tubular portion and a spaced outer tubular arm portion surrounding the distal end portion of the inner tubular portion. The inner tubular portion thus transmits fluid between the first and second containers and preferably includes a Luer connector as described above, and the outer tubular portion receives a cap or closure as described. In this preferred embodiment, the proximal end of the inner tubular portion includes a radial portion which overlies the pierceable closure of the first container and preferably includes a plurality of spaced concentric annular sealing ribs or barbs which sealingly engage the pierceable closure and assure sealed communication between the first container and the inner tubular portion or tubular transfer portion. As described above, the radial portion is integrally formed with the tubular collar portion. The radial portion may also include radial ribs, preferably adjacent the intersection between the radial portion and the tubular collar portion, which prevent rotation of the body on the first container during threaded receipt of the second container as described above. In this preferred embodiment, the body portion is also preferably reinforced with radial web portions integral with the proximal portion of the inner tubular portion and both the radial portion and the outer tubular portion of the “Y” or bell-shaped distal end portion.
In the preferred embodiments of the transfer set disclosed in this application, the distal end of the piercing member is releasably retained to the cap, simplifying the assembly of the transfer set and assuring release of the piercing member following removal of the cap. The preferred embodiment of the cap includes a central portion overlying the distal open end of the inner tubular portion of the housing includes a connector portion which receives and releasably retains the distal end of the piercing member. In the preferred embodiment, the distal end of the piercing member includes a camming surfaces having a major diameter greater than the internal diameter of the tubular connector portion of the cap, providing an interference fit. In the disclosed embodiment, the camming surface on the free distal end of the piercing member is generally spherical or semi-spherical terminating in a relatively sharp edge which bites into the internal surface of the central tubular portion of the cap, thereby releasably retaining the piercing member to the cap. The preferred embodiment of the cap further includes an outer tubular portion which is received around the distal open end of the tubular housing member having a frangible connector portion adjacent the central portion, such as an annular groove. Thus, the central portion of the cap may be removed and the piercing member is retained by the cap until the central portion is removed.
The disclosed embodiment of the cap further includes an inner tubular portion concentric with an outer tubular portion surrounding the distal end portion of the outer tubular portion of the housing spaced from the outer tubular portion which is received within the open distal open end of the outer tubular portion of the housing member assuring a good seal of the open distal end of the tubular housing member. Further, in the disclosed embodiment, the outer surface of the tubular housing member adjacent the open distal end includes an annular radial rib which is received in an axial groove in the interior surface of the outer tubular portion of the cap preferably located adjacent to the frangible connector portion assuring receipt and retention of the cap on the outer tubular portion of the housing prior to use.
Where the improved transfer set of this invention is to be sealingly attached to a vial or other container having a rim portion surrounding the open end and a reduced diameter neck portion, the tubular housing or body preferably includes a tubular collar portion integral with the radial portion described above. The body portion may then be permanently attached to the rim portion of the vial or other container by radially deforming the open end of the collar portion into the reduced diameter neck portion of the container, preferably by incrementally rolling the open end of the collar portion into the neck portion as described in the copending application Ser. No. 09/732,538, filed Dec. 8, 2000 assigned to the assignee of this application, the disclosure of which is incorporated herein by reference.
The embodiments of the transfer set of this invention may then be assembled, as follows. The piercing member may be assembled to the cap or closure by inserting the distal end of the piercing member into the annular central retaining portion of the cap, releasably retaining the piercing member to the cap. The cap may then be assembled on the open distal end of the outer tubular portion of the housing by inserting the outer tubular portion of the housing between the concentric annular tubular portions of the cap, or vice versa. The external annular rib adjacent the distal end of the outer tubular portion of the housing and internal ribs retain the cap on the housing and hermetically seal the assembly. In the preferred embodiment, the housing, cap and piercing member are formed of a sterilizable polymer as described below. The transfer set may then be permanently secured to the rim portion of a vial or other container as described above, such as the manufacture of the drug, vaccine, medicament or solution under aseptic conditions.
The transfer set of this invention may then be used to transfer fluid between the first container to which it is attached and a second container through the inner tubular transfer member. In a typical application wherein the first container, such as a vial, contains a drug, vaccine, medicament or solution in dry or liquid form, the cover or cap is removed by breaking the frangible connection between the central portion of the cap and the outer tubular portion, exposing the Luer connection on the outer surface of the inner tubular transfer member adjacent the open distal end. The second container, such as a syringe without a needle cannula having a female Luer connection, is then threadably attached to the Luer connection adjacent the distal end of the tubular transfer member. The tubular tip portion of the syringe is thereby received within the inner tubular transfer member, driving the piercing member to pierce the pierceable closure, such as a conventional elastomeric stopper, providing fluid communication between the first container and the second container. In the preferred embodiment of the transfer set, wherein the piercing member is releasably attached to the cap as described above, the removal of the central portion of the cap releases the piercing member and the tubular tip portion of the syringe is then received against the piercing member distal end during threaded attachment as described above.
Other advantages and meritorious features of the improved transfer set of this invention will be more fully understood from the following description of the preferred of embodiments, the appended claims and the drawings, a brief description of which follows.
The transfer set 20 of this invention includes three components, namely a generally tubular body or housing 40, which is affixed to the rim portion 26 of the vial 22 in sealed relation, a piercing member 42, which is adapted to pierce the central portion 36 of the stopper 30, and a cap or closure 44, which seals the open end of the transfer set 20. One advantage of the embodiments of the transfer set of this invention is the simplicity of the design. Each of the components may be formed of a sterilizable polymer and are preferably formed of a clear polymer permitting visualization of the operation and transfer of fluid between the vial 22 and a second container (not shown).
The generally tubular body 40 includes a tubular collar portion 46, which may be permanently affixed to the rim portion 26 of the vial 22 as described below, a radial portion 48 which overlies and sealingly engages the rim portion 34 of the stopper 30 and a generally “H” shaped in crosssection spaced integral outer and inner tubular portions 50 and 52, respectively, which are coaxially aligned with the opening 24 of the vial 22. The outer tubular portion 50 includes a proximal tubular portion 50a and a distal tubular portion 50b and the inner tubular portion 52 includes a proximal tubular portion 52a and a distal tubular portion 52b. The outer tubular portion 50 is integrally joined with the inner tubular portion 52 by a radial web portion 54. As will be understood, the generally tubular body 40 may thus be integrally formed by conventional molding techniques, including injection molding. Because the transfer set 20 is adapted to transfer fluid between the vial 22 and a second container (not shown) through the inner tubular portion 52, the inner and outer tubular portions 52 and 50, respectively, are preferably sealingly supported on the stopper 30. In this embodiment of the transfer set 20, the proximal portion 52a of the inner tubular portion 52 includes an annular sharp edge 56 preferably coincident with the internal surface of the proximal inner tubular portion 52a sealing the communication between the vial 22 and the inner tubular transfer member 52. The proximal portion 50a of the outer tubular portion 50 also includes an annular rib 58 preferably having a sharp circular edge which provides a redundant seal and prevents entry of foreign matter into the tubular transfer member 20. The radial portion 48 of the body 40 may additionally include a concentric sealing rib (not shown) surrounding the sealing rib 58, providing redundant sealing.
The cap or closure 44 is generally cup-shaped, including a generally planer central portion 60 which overlies the distal outer tubular portion 50b as shown in
The piercing member 42 in the disclosed embodiment includes a body portion 80, a reduced diameter piercing portion 82 having a relatively sharp piercing end 84, a radial flange portion 86 between the body portion 80 and the piercing portion 82 and a head portion 90. A longitudinal channel 92 extends from the piercing end 84 through the radial flange 86 into the body portion 80 as shown in
Because the diameter of the radial flange portion 86 of the piercing member 42 is greater than the internal diameter of the inner tubular portion 52b distally of the abutment surface 53 to prevent removal of the piercing member 42 during removal of the cap 44 as shown in
As will be understood by those skilled in this art, the transfer set 20 of this invention may be assembled at one facility, such as the manufacturer of the transfer set under aseptic conditions, packaged in a sterile container and supplied to a drug manufacturer, for example. After filling the vial 22 with a suitable drug, vaccine, medicament or solution, the drug manufacturer may then permanently attach the transfer set 20 on the vial 22 as now briefly described. First, the tubular collar portion 46 is received around the rim portion 26 of the vial 22 and the transfer set 20 is then compressed against the rim portion 34 of the stopper 30, which drives the sharp edge 56 of the proximal end 52a of the inner tubular portion 52 and the annular rib 58 on the proximal portion 50a of the outer tubular portion 50 into the rim portion 34 of the stopper 30, sealing the transfer set to the stopper 30. The free open end 46a of the collar portion 46 is then deformed radially into the reduced diameter neck portion 28 of the vial 22 beneath the rim portion 26 of the vial, preferably with a roller 100 having a frustoconical surface 102 which incrementally rolls the free open end 46a of the tubular collar portion 46 into the reduced diameter neck portion 28 to avoid cracking. Alternatively, as described in the above-referenced copending U.S. application Ser. No. 09/732,538 assigned to the assignee of this application, the transfer set 20 and vial assembly may be rolled against a frustoconical surface, permanently attaching the transfer set to the vial 22 or other container.
Having described a preferred embodiment of the transfer set 20 and the method of assembly, the use of the transfer set by a healthcare worker or patient can now be described as follows. First, the cap 44 is removed by lifting the annular lip 72 with the fingers. The piercing member 42 is then released from the cap 44, wherein the flange 86 engages the abutment surface 53 on the interior surface of the inner tubular portion 52. The transfer set may then be used to either withdraw fluid from the vial 22 or to add fluid to the vial to reconstitute a dry or lyophilized drug, vaccine or medicament in the vial 22 for example. In the preferred embodiment, the distal portion 52b of the inner tubular member 52 includes a Luer connector 51 to receive the Luer connector of the second container (not shown), such as the tip portion of a conventional syringe without a needle cannula. As the tip portion of the syringe is threadably received on the Luer connector 51, the tip portion engages the distal end 94 of the piercing member and drives the piercing member through the central portion 36 of the stopper 30, establishing fluid communication through the central portion 36 through the channel 92 of the piercing member 42. Fluid, such as a diluent or solvent, may then be added to the vial to reconstitute a powder or lyophilized medicament, drug or vaccine, or fluid may be removed from the vial using the plunger of the syringe (not shown).
The generally tubular body or housing 140 shown in more detail in
The embodiment of the transfer set 20 shown in
As will be understood by those skilled in this art, various modifications may be made to the disclosed preferred embodiments of the transfer set of this invention within the purview of the appended claims. For example, various piercing members may be utilized with the transfer set of this invention, including but not limited to a piercing member having an axial bore. The number of barbs on the radial portion which bite into the rim portion 34 of the stopper will also depend upon the sealing requirements and the size of the vial as will be understood from the above description. Other cap designs may also be utilized with the tubular body including, for example, peel-off closures as disclosed in the above-referenced copending patent applications. Finally, although the components of the transfer set of this invention may be formed of various polymers, the tubular body 40, 140 is preferably formed of a polymer which is sufficiently malleable to permit radial deformation of the tubular collar into the neck 28 of the vial 22, yet sufficiently rigid to retain its shape following deformation and resistant to creep to maintain a good seal between the collar portion of the transfer set and the vial and the polymer selected for the tubular body is preferably clear or transparent. As described more fully in the above-referenced copending application Ser. No. 09/684,123, such polymers include melt blends, alloys and copolymers of polycarbonate or polyamid and polyester. Having described the preferred embodiments of the transfer set of this invention, the invention is now claimed as follows.
This application is a continuation-in-part application of U.S. Ser. No. 09/684,123, filed Oct. 5, 2000 now U.S. Pat. No. 6, 626,309, which Application was a continuation-in-part of U.S. Ser. No. 09/420,979, filed Oct. 20, 1999 now U.S. Pat. No. 6,378,714, which Application was a continuation-in-part of U.S. Ser. No. 09/168,502, filed Oct. 8, 1998 now U.S. Pat. No. 6,382,442, claiming priority under 35 U.S.C. § 119(e) to U.S. Provisional Application Ser. No. 60/082,372, filed Apr. 20, 1998.
Number | Name | Date | Kind |
---|---|---|---|
37221 | Dunton | Dec 1862 | A |
659519 | De Oliveria | Oct 1900 | A |
2342215 | Perelson | Feb 1944 | A |
2388634 | De Woody | Nov 1945 | A |
2524365 | Smith | Oct 1950 | A |
2607503 | Sonnenberg | Aug 1952 | A |
2653609 | Smith | Sep 1953 | A |
2659370 | Smith | Nov 1953 | A |
2667986 | Perelson | Feb 1954 | A |
2953132 | Richter et al. | Mar 1960 | A |
3033202 | Richter et al. | May 1962 | A |
3164303 | Trautmann | Jan 1965 | A |
3206080 | Scislowicz | Sep 1965 | A |
3278063 | Kranzhoff | Oct 1966 | A |
3356093 | Monahon | Dec 1967 | A |
3357427 | Wittke et al. | Dec 1967 | A |
3610297 | Raaf et al. | Oct 1971 | A |
3674028 | Ogle | Jul 1972 | A |
3779371 | Rovinksi | Dec 1973 | A |
3810469 | Hurschman | May 1974 | A |
3826260 | Killinger | Jul 1974 | A |
3838689 | Cohen | Oct 1974 | A |
3872867 | Killinger | Mar 1975 | A |
3872992 | Larson | Mar 1975 | A |
3940003 | Larson | Feb 1976 | A |
3977555 | Larson | Aug 1976 | A |
3995630 | Van De Veerdonk | Dec 1976 | A |
4020839 | Klapp | May 1977 | A |
4048999 | Kobel | Sep 1977 | A |
4067440 | Lataix | Jan 1978 | A |
4153057 | Kobel | May 1979 | A |
4187893 | Bujan | Feb 1980 | A |
4210255 | Pan | Jul 1980 | A |
4296786 | Brignola | Oct 1981 | A |
4336891 | Smith | Jun 1982 | A |
4387879 | Tauschinski | Jun 1983 | A |
4412623 | Schmidt | Nov 1983 | A |
4418827 | Butterfield | Dec 1983 | A |
4425120 | Sampson et al. | Jan 1984 | A |
4460735 | Froix | Jul 1984 | A |
4493348 | Lemmons | Jan 1985 | A |
4505709 | Froning et al. | Mar 1985 | A |
4507113 | Dunlap | Mar 1985 | A |
4564054 | Gustavsson | Jan 1986 | A |
4573506 | Paoletti | Mar 1986 | A |
4573976 | Sampson et al. | Mar 1986 | A |
4576211 | Valentini et al. | Mar 1986 | A |
4588403 | Weiss et al. | May 1986 | A |
4619651 | Kopfer et al. | Oct 1986 | A |
4624393 | Lopez | Nov 1986 | A |
4639250 | Rycroft | Jan 1987 | A |
4662878 | Lindmayer | May 1987 | A |
4672996 | Floyd et al. | Jun 1987 | A |
4673404 | Gustavsson | Jun 1987 | A |
4675020 | Mc Phee | Jun 1987 | A |
4792053 | Towne et al. | Dec 1988 | A |
4822351 | Purcell | Apr 1989 | A |
4826491 | Schramm | May 1989 | A |
4834149 | Fournier et al. | May 1989 | A |
4834152 | Howson et al. | May 1989 | A |
4850994 | Zerbet et al. | Jul 1989 | A |
4884703 | O'Meara | Dec 1989 | A |
4909290 | Coccia | Mar 1990 | A |
4913945 | Maruhashi et al. | Apr 1990 | A |
4923447 | Morgan | May 1990 | A |
4927423 | Malmborg | May 1990 | A |
4932937 | Gustavsson et al. | Jun 1990 | A |
4982740 | Broden | Jan 1991 | A |
5006118 | Yule | Apr 1991 | A |
5024256 | Vadjer | Jun 1991 | A |
5035689 | Schroeder | Jul 1991 | A |
5060812 | Ogle, II | Oct 1991 | A |
5088996 | Kopfer et al. | Feb 1992 | A |
5092840 | Healy | Mar 1992 | A |
5116326 | Schmidt | May 1992 | A |
5169385 | Turnball | Dec 1992 | A |
5171214 | Kolber et al. | Dec 1992 | A |
5215538 | Larkin | Jun 1993 | A |
5217433 | Bunin | Jun 1993 | A |
5232029 | Knox et al. | Aug 1993 | A |
5232109 | Tirrell et al. | Aug 1993 | A |
5250037 | Bitdinger | Oct 1993 | A |
5275299 | Konrad et al. | Jan 1994 | A |
5279576 | Loo et al. | Jan 1994 | A |
5291991 | Meyer | Mar 1994 | A |
5297599 | Bucheli | Mar 1994 | A |
5342319 | Watson et al. | Aug 1994 | A |
5348548 | Meyer et al. | Sep 1994 | A |
5350372 | Ikeda et al. | Sep 1994 | A |
5352196 | Haber et al. | Oct 1994 | A |
5358501 | Meyer | Oct 1994 | A |
5360413 | Leason et al. | Nov 1994 | A |
5364386 | Fukuoka et al. | Nov 1994 | A |
5385546 | Kriesel et al. | Jan 1995 | A |
5397303 | Sancoff et al. | Mar 1995 | A |
5409125 | Kimber et al. | Apr 1995 | A |
5411499 | Dudar et al. | May 1995 | A |
5415374 | Carroll et al. | May 1995 | A |
5419256 | Pollich | May 1995 | A |
5421814 | Geary | Jun 1995 | A |
5423791 | Bartlett | Jun 1995 | A |
5425465 | Healy | Jun 1995 | A |
5429256 | Kestenbaum | Jul 1995 | A |
5433330 | Yatsko et al. | Jul 1995 | A |
5433703 | Utterberg et al. | Jul 1995 | A |
5435282 | Haber et al. | Jul 1995 | A |
5437648 | Graves et al. | Aug 1995 | A |
5441487 | Vedder | Aug 1995 | A |
5454409 | Mc Affer et al. | Oct 1995 | A |
5454805 | Brony | Oct 1995 | A |
5466219 | Lynn et al. | Nov 1995 | A |
5470319 | Mayer | Nov 1995 | A |
5470327 | Helgren et al. | Nov 1995 | A |
5474541 | Ritsky et al. | Dec 1995 | A |
5474544 | Lynn | Dec 1995 | A |
5487737 | Meyer | Jan 1996 | A |
5494170 | Burns | Feb 1996 | A |
5501676 | Niedospial et al. | Mar 1996 | A |
5514116 | Vaillancourt et al. | May 1996 | A |
5514117 | Lynn | May 1996 | A |
5520641 | Behnke et al. | May 1996 | A |
5520642 | Bigagli et al. | May 1996 | A |
5520661 | Lal et al. | May 1996 | A |
5520665 | Fleetwood | May 1996 | A |
5520666 | Choudhury et al. | May 1996 | A |
5533983 | Haining | Jul 1996 | A |
5533994 | Meyer | Jul 1996 | A |
5549651 | Lynn | Aug 1996 | A |
5566729 | Grabenkort et al. | Oct 1996 | A |
5573516 | Tyner | Nov 1996 | A |
5573520 | Schwartz et al. | Nov 1996 | A |
5573525 | Watson et al. | Nov 1996 | A |
5573526 | Hess | Nov 1996 | A |
5576392 | Yamamoto et al. | Nov 1996 | A |
5598939 | Watson et al. | Feb 1997 | A |
5613291 | Solomon et al. | Mar 1997 | A |
5616129 | Mayer | Apr 1997 | A |
5616130 | Mayer | Apr 1997 | A |
5620434 | Brony | Apr 1997 | A |
5641010 | Maier | Jun 1997 | A |
5662230 | Finneran | Sep 1997 | A |
5685845 | Grimard | Nov 1997 | A |
5697915 | Lynn | Dec 1997 | A |
5702019 | Grimard | Dec 1997 | A |
5709666 | Reynolds | Jan 1998 | A |
5718348 | Manera | Feb 1998 | A |
5776124 | Wald | Jul 1998 | A |
5776125 | Dudar et al. | Jul 1998 | A |
5785701 | Sams et al. | Jul 1998 | A |
5803284 | Grimard | Sep 1998 | A |
5819964 | Grimard | Oct 1998 | A |
5833089 | Manni et al. | Nov 1998 | A |
5855575 | Solomon et al. | Jan 1999 | A |
5857579 | Finneran | Jan 1999 | A |
5863655 | Mock | Jan 1999 | A |
5873872 | Thibault et al. | Feb 1999 | A |
5879345 | Aneas | Mar 1999 | A |
5890610 | Jansen et al. | Apr 1999 | A |
5891129 | Daubert et al. | Apr 1999 | A |
5925029 | Jansen et al. | Jul 1999 | A |
5931828 | Durkee | Aug 1999 | A |
5954104 | Daubert et al. | Sep 1999 | A |
5957898 | Jepson et al. | Sep 1999 | A |
6003566 | Thibault et al. | Dec 1999 | A |
6050435 | Bush et al. | Apr 2000 | A |
6056135 | Widman | May 2000 | A |
6070623 | Aneas | Jun 2000 | A |
6071270 | Fowles et al. | Jun 2000 | A |
6090093 | Thibault et al. | Jul 2000 | A |
6113583 | Fowles et al. | Sep 2000 | A |
6159192 | Fowles et al. | Dec 2000 | A |
6189580 | Thibault et al. | Feb 2001 | B1 |
6209738 | Jansen et al. | Apr 2001 | B1 |
6213994 | Jansen et al. | Apr 2001 | B1 |
6378576 | Thibault et al. | Apr 2002 | B2 |
Number | Date | Country |
---|---|---|
0 236 127 | Mar 1987 | EP |
0 406 374 | Dec 1989 | EP |
0 769 456 | Oct 1996 | EP |
0 747 293 | Dec 1996 | EP |
0 065 469 | May 1999 | EP |
1.328.635 | Jul 1962 | FR |
WO 8404673 | Dec 1984 | WO |
WO 8801881 | Mar 1988 | WO |
WO 9211056 | Jul 1992 | WO |
WO 9403373 | Mar 1994 | WO |
WO 9500117 | Jan 1995 | WO |
WO 9503841 | Feb 1995 | WO |
WO 9514176 | May 1995 | WO |
WO 9531242 | Nov 1995 | WO |
WO 9533505 | Dec 1995 | WO |
WO 9535125 | Dec 1995 | WO |
WO 9613301 | May 1996 | WO |
WO 9700702 | Jan 1997 | WO |
WO 9710156 | Mar 1997 | WO |
WO 9739720 | Oct 1997 | WO |
WO 9813006 | Apr 1998 | WO |
WO 9832411 | Jul 1998 | WO |
WO 9837853 | Sep 1998 | WO |
WO 9837854 | Sep 1998 | WO |
WO 99 43282 | Sep 1999 | WO |
WO 99 53886 | Oct 1999 | WO |
WO 01 28489 | Apr 2001 | WO |
WO 01 28490 | Apr 2001 | WO |
WO 01 32524 | May 2001 | WO |
Number | Date | Country | |
---|---|---|---|
20020121496 A1 | Sep 2002 | US |
Number | Date | Country | |
---|---|---|---|
60082372 | Apr 1998 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 09684123 | Oct 2000 | US |
Child | 10059497 | US | |
Parent | 09420979 | Oct 1999 | US |
Child | 09684123 | US | |
Parent | 09168502 | Oct 1998 | US |
Child | 09420979 | US |