Translation Studies of the Planet Specific Receptor Trem Like Transcript (TLT)

Information

  • Research Project
  • 10439320
  • ApplicationId
    10439320
  • Core Project Number
    R01HL090933
  • Full Project Number
    3R01HL090933-08S1
  • Serial Number
    090933
  • FOA Number
    PA-18-484
  • Sub Project Id
  • Project Start Date
    6/16/2011 - 13 years ago
  • Project End Date
    6/30/2022 - 2 years ago
  • Program Officer Name
    SARKAR, RITA
  • Budget Start Date
    7/1/2021 - 3 years ago
  • Budget End Date
    6/30/2022 - 2 years ago
  • Fiscal Year
    2021
  • Support Year
    08
  • Suffix
    S1
  • Award Notice Date
    9/17/2021 - 3 years ago
Organizations

Translation Studies of the Planet Specific Receptor Trem Like Transcript (TLT)

Project Summary According to the World Health Organization, Cardiovascular disease (CVD) is responsible for 31% of deaths worldwide making it the largest global cause of mortality. These numbers are reflected in the United states where over 600,000 people died of CVD. CVD is an inflammatory disease that often leads to mortality by thrombosis and platelets mediate both the inflammatory and thrombotic aspects of CVD. Our laboratory studies the Triggering receptor expressed in myeloid cells or (TLT-1) that is stored in the ??granules of the platelets and is both expressed to the platelet surface and released after platelet activation. TLT-1 binds fibrinogen. While TLT-1 has demonstrated roles in Cardiovascular disease, sepsis, and acute lung injury, its interaction with fibrinogen is poorly understood. We hypothesize that TLT-1?s interaction with fibrinogen is a major pathway by which the immune system commandeers the hemostatic system for immune function. In this application we propose to mechanistically define this interaction and demonstrate is usefulness as a therapeutic target. We propose the following three aims: Aim I ? Determine the relative contribution of fibrinogen binding to TLT-1 and ?IIb?2 using double deficient (treml1-/-/itga2b-/-) mice; Aim II - Elucidate TLT-1 signaling pathways; Aim III ? Evaluate the effect of TLT-1 prophylactics on the progression of CVD and obesity. At the completion of these aims we will have defined TLT-1?s contribution to platelet interaction with fibrinogen and is potential as a therapeutic target.

IC Name
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
  • Activity
    R01
  • Administering IC
    HL
  • Application Type
    3
  • Direct Cost Amount
    41029
  • Indirect Cost Amount
    33471
  • Total Cost
    74500
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    839
  • Ed Inst. Type
    SCHOOLS OF ARTS AND SCIENCES
  • Funding ICs
    NHLBI:74500\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    OAKLAND UNIVERSITY
  • Organization Department
    BIOLOGY
  • Organization DUNS
    041808262
  • Organization City
    ROCHESTER
  • Organization State
    MI
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    483094422
  • Organization District
    UNITED STATES