This present claims priority to French Patent Application No. 2211348, filed Oct. 31, 2022, the disclosure of which is hereby incorporated by reference in its entirety.
The present disclosure relates to a transparent, gas-permeable, and waterproof film, particularly for applications in the medical field.
Although not exclusively, the transparent, gas-permeable, and waterproof film is applied, more particularly, to an identification card used in an identification test used, in medical diagnostics, to identify bacteria.
In the field of medical diagnosis, the medical profession often relies on the results of bacterial identification tests and antibiograms to determine the most appropriate antibiotic treatment for a patient's pathology and to monitor the evolution of the resistance in these bacteria to the antibiotics. These identification tests enable the pathogen responsible for an infection to be determined quickly and reliably.
To carry out such identification tests, it is necessary to use identification cards. The identification cards are disposable and single-use can quickly and accurately identify a wide variety of clinically relevant species of bacteria and yeasts. Each identification card has micro-wells containing identification substrates. To carry out an identification test, the solution to be analysed is injected into channels on the identification card, then the whole assembly is placed in an incubator. The platelets are then analysed using a range of standard methods.
To protect the culture medium from external pollution, each identification card is sealed on both sides with a transparent adhesive film.
The transparent adhesive film used for this purpose must have strict particular characteristics, in particular:
Polymethylpentene (PMP) films are generally used for such applications. However, these polymethylpentene films have fixed values for the above characteristics.
There is therefore an interest and a need to be able to modify the values of these characteristics of the film in order to adapt them more precisely to those actually required for the applications envisaged.
The purpose of this invention is to provide a transparent, gas-permeable, and waterproof film that can be used, in particular, in the above applications and to meet this need.
According to the disclosure, said film comprises a polyolefin base (matrix) to which is added at least one monomeric plasticiser with a percentage by mass of the monomeric plasticiser of between 10% and 50%, and preferably of between 15% and 45%.
In a preferred embodiment, said film also comprises molecular sieves with a percentage by mass of less than or equal to 20%, and preferably less than or equal to 10%.
In this way, the disclosure produces a film that has, in particular, as specified below, high permeability to gases (oxygen, carbon dioxide), low permeability to water (liquid) and high transparency, as well as various mechanical properties and characteristics. Depending on the proportion of elements (monomeric plasticiser, molecular sieve) added to the polyolefin base, the properties of the film can be modified and adapted to the properties required for the applications envisaged.
This film is particularly suitable for use on an identification card as described above. However, thanks to its surprising and advantageous characteristics, said film can also be used in many other applications, particularly but not exclusively in the medical field.
Advantageously, the polyolefin matrix corresponds to one of the following components: a PP homopolymer (made of polypropylene) or a PP/PE block or random copolymer (PP polypropylene and PE polyethylene).
In addition, it is advantageous that the monomeric plasticiser is dioctyl sebacate (DOS).
Also, the molecular sieves are advantageously made from at least one of the following materials: cyclodextrins (CD), zeolites, polyhedral oligomeric silsesquioxane (POSS), metal organic frameworks (MOF), covalent organic frameworks (COF).
In addition, in a particular embodiment:
Other advantages and characteristics will become clearer from the following description of several non-limiting examples of a film according to the disclosure, referring, in particular, to the attached figures. In these figures, identical references designate similar elements.
The film 1 used to illustrate the disclosure and shown in two different embodiments in
In the first embodiment shown in
Furthermore, in the second embodiment (which is the preferred embodiment), the film 1 is also formed, as shown in
In this second (preferred) embodiment, the material 2 of the film 1 also comprises molecular sieves 5, illustrated schematically by black dots in
The addition of the monomeric plasticiser 4 and the molecular sieves 5 produces a surprising effect, in particular, in terms of (high) gas permeability, enabling advantageous characteristics to be obtained.
As explained below, the film 1 made from the material 2 has the following characteristics and advantages:
These high gas permeabilities are illustrated in
The film 1 made from the material 2 also has the following characteristics:
These last characteristics make the film 1 flexible and easy to handle, and, in particular, sufficiently easy to handle for the applications envisaged.
In each of the formulation modes, the polyolefin matrix 3 corresponds to one of the following components:
The (starting) polyolefin matrix 3 enables, in particular for thicknesses E of film 1 of between 25 and 100 μm, the transparency criteria required for the applications envisaged to be met and to provide sufficient hydrophobicity to guarantee low water flows (in the liquid state).
In addition, the polyolefin matrix 3 can be easily melt-processed. A melt method is preferably used both for the various stages of formulating the material 2 and for shaping the film 1. Such a method has the particular advantage of having a low environmental impact with respect to a solvent phase method and is economically attractive from an industrial point of view. Preferably, any modifications made to the polymers used are carried out by a melt method.
In addition, the additives (the monomeric plasticiser 4 and the molecular sieves 5) incorporated into the polyolefin matrix 3 have sufficient thermal stability for the conditions of implementation by the melt method and enable a low permeability to water to be maintained.
A polyolefin matrix 3 as used in this disclosure thus has, in particular, the following characteristics and advantages:
In addition, whatever the method used, the monomeric plasticiser 4 (comprising organic molecules with a low molar mass) added to the polyolefin matrix 3 is preferably dioctyl sebacate (DOS).
The addition of monomeric plasticiser 4 to the polyolefin matrix 3, without damaging the optical properties of the polyolefin matrix 3, increases its permeability to gases by plasticising the polymer chains of the polyolefin matrix 3.
To improve the gas permeability of the polyolefin matrix 3, low molar mass organic molecules are added, in particular, to increase the mobility of the polymer chains. An increase in the mobility of the latter, or more generally of the permeation medium, leads to an increase in permeability.
Furthermore, in said second (preferred) embodiment, the molecular sieves 5 that are added correspond to at least one of the following materials:
In particular, the use of molecular sieves and, more specifically, zeolites (which have little effect on mechanical properties apart from the strain at break) is highly advantageous.
In the second embodiment, the gas permeability of the film 1 is greatly increased by the addition of both the monomeric plasticiser 4 and molecular sieves 5, while retaining sufficient mechanical and optical properties for the intended applications.
In a first embodiment, the molecular sieves 5 are all made of one and the same material, from among the aforementioned materials.
In addition, in a second embodiment, the material 2 comprises at least two different types of molecular sieve 5, a first type of which is made from a first material (among the aforementioned materials) and a second type of which is made from a second material (among the aforementioned materials) different from said first material.
In the present disclosure, the molecular sieves 5 have a percentage by mass of between 0% (first embodiment) and 20%, and preferably between 0% and 10%, of the total mass of the material 2 of the film 1.
The table below shows the main characteristics of the film 1 for four different formulations F1, F2, F3 and F4 of the material 2.
This table shows the values of at least some of the parameters considered for the different formulations F1, F2, F3 and F4.
In this table, the formulations F1 and F2 refer to the first embodiment (
Specifically:
This table highlights the following advantageous characteristics of the different formulations:
The four formulations F1 to F4 all have good gas permeability properties. In addition, the formulations F3 and F4 have improved mechanical properties.
The following is an example of a process for manufacturing a film 1 such as that described above.
During this manufacturing method, first of all the polyolefin matrix 3 is melted.
Next, the components corresponding to the relevant production method are added to the molten polyolefin matrix 3, and the whole is mixed in a conventional mixer.
Thus, to manufacture the material 2 according to the first embodiment, the monomeric plasticiser 4 is added to the polyolefin matrix 3, and the whole is mixed.
In addition, to manufacture the material 2 according to the second embodiment, both the monomeric plasticiser 4 and the molecular sieves 5 are added to the polyolefin matrix 3, and the whole is mixed.
In this case, the monomeric plasticiser 4 and the molecular sieves 5 can be added simultaneously to the polyolefin matrix 3. The monomeric plasticiser 4 and the molecular sieves 5 can also be added successively to the polyolefin matrix 3, starting with the monomeric plasticiser 4 or the molecular sieves 5, depending on the manufacturing method envisaged.
The various stages (melting, mixing) in the manufacturing method are carried out in the usual way.
When the mixture is homogeneous, the material 2 obtained is transformed and shaped in the usual way, in the molten state, for example using an extrusion operation, to obtain the film 1 with the desired characteristics, in particular, in terms of thickness.
By way of illustration, for use on an identification card, the thickness E (
As indicated above, such a melt manufacturing method (for manufacturing the material 2 and shaping the film 1) has in particular the advantage of having a low environmental impact compared with a solvent phase method and is economically attractive from an industrial point of view.
In a particular embodiment, a layer of adhesive (not shown) is applied in the usual way to at least one of the sides 1A and 1B of the film 1. The adhesive film 1 obtained in this way can then be easily stuck to a support for the intended application.
The film 1, as described above, is particularly well suited for use on an identification card, thanks to its following characteristics:
The film 1, as described above, can also be used in many other applications, particularly (but not exclusively) in the medical sector and especially in the field of diagnostics. More generally, the film 1 can be used in all applications in which its advantageous characteristics, and in particular its high gas permeability (allowing gas exchange while providing water barrier properties), are required.
It is clear that the examples presented above are only specific illustrations, and in no way limit the fields of application of this disclosure. In addition, characteristics of some of these different examples may be combined with each other where appropriate, without departing from the scope of this disclosure.
Number | Date | Country | Kind |
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2211348 | Oct 2022 | FR | national |