The present invention relates to a transport mechanism and an analyzing device.
A device that can perform a plurality of types of analysis based on different measurement methods, such as a biochemical analysis and an immunological analysis, has been proposed (e.g. PTL 1). This device includes: (1) a sample supply unit that includes a sample rack on which a plurality of biological samples are placed, (2) a first measuring unit which can hold a plurality of mutually independent reaction cuvettes so as to be removable independently from each other, and includes a first optical system measuring member, (3) a sample transport member that can transport biological samples from the sample supply unit to the reaction cuvettes on the first measuring unit, (4) a second measuring unit that can hold a plurality of mutually independent reaction cuvettes so as to be removable independently from each other, and includes a second optical system measuring member, (5) a cuvette transfer member that can transfer the reaction cuvettes on the first measuring unit to the second measuring unit, (6) a reagent supply unit that contains reagent that is used for the measurement in the first measuring unit and the measurement in the second measuring unit, and (7) a reagent transport member that can transport reaction reagent from the reagent supply unit to the reaction cuvettes on the first measuring unit and/or the second measuring unit independently. After the biological samples are dispensed on the first measuring unit, the reaction cuvettes on the second measuring unit are transferred by the cuvette transfer member from the first measuring unit to the second measuring unit, and are held by the second measuring unit, whereby different measurements can be performed in the first measuring unit and in the second measuring unit, respectively.
An automatic immunological analyzing device that is also proposed includes: a rack on which reaction containers are vertically held; a means that circulates the rack endlessly for intermittently transferring the rack; and a means that dispenses a required amount of a sample to each reaction container at a predetermined position of a rack transfer path through which the rack is transferred (e.g., PTL 2).
An automatic analyzing device that is also proposed includes: a transport line for transporting a rack, on which sample containers containing samples are set, from a rack entry unit to a rack storing unit; and an analyzing unit that is disposed between the rack entry unit and the rack storing unit along the transport line. This automatic analyzing device includes: a circulating line configured to circulate a rack from the rack storing unit side to the rack entry unit side; an entry side rack number reading unit that is disposed on the entry side of the transport line, and reads a rack number of a rack that is transported; a storage unit that stores the sequence of racks read by the entry side rack number reading unit; a storing side rack number reading unit that is disposed on the storage side of the transport line and reads a rack number of a rack that is transported; and a control unit that stores a rack in the rack storing unit if the rack of which rack number is read by the storing side rack number reading unit is in a sequence to be stored, or circulates the rack to the rack entry side via the circulating line if not (e.g. PTL 3).
Generally for analyzing devices which automatically perform some kind of test on a specimen, decreasing the time required for the test is demanded. It is an object of the present invention to improve the efficiency of the sampling processing.
A transport mechanism according to the present invention is a transport mechanism that is disposed in a measuring device used for dispensing biological samples from sample containers configured to contain the biological samples to cuvettes, so as to perform a predetermined measurement, and transports a sample rack configured to hold the sample containers, the transport mechanism including: a table on which the sample rack is provided in plurality and sequentially placed; a container sensor unit configured to identify the sample containers held on the sample rack; and a transport device configured to transport the sample rack holding the sample containers identified by the container sensor unit to a dispensing position at which the biological samples are dispensed. The container sensor unit is disposed in the transport device, so that the transport device transports a preceding sample rack while the container sensor unit identifies the sample containers held on a subsequent sample rack.
Since a preceding sample rack is transported while sample containers held on a subsequent sample rack are identified, the presence of each sample container and identification information thereof can be specified (an advance-read operation), and throughput per unit time can be improved. In other words, the efficiency of the sampling processing can be improved.
The transport mechanism may further include a sample rack detecting device configured to determine whether the subsequent sample rack exists, and when the sample rack detecting device determines that the subsequent sample rack exists, the container sensor unit may identify sample containers held on the subsequent sample rack. Then the above mentioned advance-read operation can be performed after determining whether the subsequent sample rack is continuously carried in.
Predetermined identification information may be indicated on an outer face of each of the sample containers, and the container sensor unit may include: a sample container identifying device configured to read the identification information indicated on each of the sample containers; and a type determining device configured to determine a type of each of the sample containers. The transport device may transport a preceding sample rack, while the sample container identifying device reads the identification information indicated on each sample container held on the subsequent sample rack, and the type determining device may determine the type of each of the sample containers held on the subsequent sample rack. Then in a case of processing a plurality of types of sample containers, the type of each container can be determined. The type detecting device may be an infrared sensor, for example, and may determine the type of each sample container based on the shape (e.g., height) of the sample container. In a case where both the identification information and type of each sample container are successfully read, it may be determined that this sample container is held on the sample rack, and may be regarded as a target of sampling in the subsequent processing steps.
The sample rack may hold a plurality of sample containers in a row in a first direction in plan view, and a plurality of sample racks may be placed on a table in a second direction, which is perpendicular to the first direction, in plan view. The transport device may transport a preceding sample rack in the first direction, while the container sensor unit identifies the sample containers held on a subsequent sample rack. Thereby the direction of transporting the preceding sample rack matches with the direction of the sample containers lined up in the subsequent sample rack, and the processing of the transport device transporting the preceding sample rack and the processing of identifying the sample containers held on the subsequent sample rack, can be performed in parallel.
An analyzing device according to another aspect of the present invention may include the abovementioned transport mechanism and a computer that controls operation of the transport mechanism. Thereby the efficiency of the sampling processing of the analyzing device can be improved.
The content described in “Solution to Problem” may be combined within a scope of not departing from the problem and technical spirit of the present invention. And the content described in “Solution to Problem” can be provided as a system, including a device or a plurality of devices (e.g. computer(s)), a method executed by a computer, or a program executed by a computer. This program may be executed over a network. A recording medium holding this program may be provided.
The present invention can improve the efficiency of the sampling processing.
An analyzing device according to an embodiment will be described with reference to the drawings.
<Device Configuration>
The cuvette supply unit 102 supplies a predetermined-shaped cuvette for use by the analyzing device 1000. The sample nozzle unit 103, which includes a nozzle connected with a pump, moves in a predetermined movable range based on the control by the computer, and collects a sample from each sample container and discharges the sample to a cuvette on the LPIA table 108. Specifically, the sample nozzle unit 103 rotates in a circular-shaped arc in plan view, with a predetermined rotating shaft at the center. In the plan view, a dispensing position is set at an intersection between the circular arc track on which the sample nozzle unit 103 moves, and a circular track on which the cuvettes, disposed in a circle on the LPIA table 108, rotationally move. Further, in the plan view, a nozzle cleaning tank may be disposed on the track on which the sample nozzle unit 103 moves.
The reagent table 104 is a disk type holding unit, on which a plurality of reagent containers containing reagent are held, and rotates based on the control by the computer. Reagent in each reagent container that is held is collected by the reagent nozzle unit 106 at a predetermined collecting position. The reagent cover open/close unit 105 is a unit that moves in a predetermined movable range, and opens/closes the cover of the reagent container based on the control by the computer. The reagent nozzle unit 106, which includes a nozzle connected with a pump, moves in a predetermined movable range based on the control by the computer, and collects reagent from each reagent container and discharges the reagent to each cuvette. In the plan view, a reagent nozzle cleaning rank may be disposed on the path where the reagent nozzle unit 106 linearly moves.
The coagulation table 107 is a holding unit having a plurality of holes which lineup to hold a plurality of cuvettes to measure a degree of coagulation of content of each cuvette. A light source and a light receiving unit are disposed on each side of the cuvettes to be held, and the degree of coagulation is measured based on the absorbance or transmittance of the content. In the plan view, an attaching/detaching position is set at a position where the track on which the cuvette chuck unit 109 crosses.
The LPIA table 108, which is a disk type holding unit, holds a plurality of cuvettes arranged in a circle in the plan view, in order to measure the antigen level in a sample by LPIA, and rotates based on the control by the computer. Each cuvette to be held is attached or detached by the cuvette chuck unit 109 at a predetermined attaching/detaching position, and reagent is dispensed to each cuvette at a predetermined dispensing position.
The cuvette chuck unit 109 moves in a predetermined movable range, and holds and moves the cuvettes based on the control by the computer. The rail 110 is a linear rail, and the reagent nozzle unit 106 and the cuvette chuck unit 109 move on the rail 110 respectively. The cuvette discarding port 111 is an opening linked to the discarding box stored in the tank housing portion 2, and is used for discarding cuvettes into the cuvette discarding port 111.
The carry-in device 1018 is disposed below the slits 1011, and allows protruding pieces (not illustrated) to protrude out to/recede from the table 101 through the slits 1011, and moves the protruding pieces in the protruded state in the front/back direction along the slits 1011, so that the sample rack 5, placed on a carry-in lane (arrow D1 in
The rack detecting device 1016 is a porcelain sensor disposed under the table 101, for example, and exists at a plurality of locations indicated by circles (broken lines) in
The container identifying device 1014 and the container type determining device 1015 are connected to the transport device 1013, and move in tandem as one unit. The transport device 1013 has two rack holding units 10131 in the front area in the transporting direction of the sampling lane, and has the container identifying device 1014 and the container type determining device 1015 in the rear area in the transporting direction of the sampling lane. Therefore, while transporting the preceding sampling rack 5 held between the two rack holding units 10131, the container identifying device 1014 reads the identification information attached to the side face of each sample container 52 held on the subsequent sample rack 5, and the container type determining device 1015 determines the type of the sample container 52. The container identifying device 1014 and the container type determining device 1015 are collectively referred to as a “container sensor unit”.
In this embodiment, transport of the preceding sample rack 5 or sampling from each sample container 52 held by the preceding sample rack 5, and identification of each sample container 52 held by the subsequent sample rack 5, are performed in parallel, whereby the sampling of the subsequent sample rack 5 is quickly started, and the dispensing operation to each vacant holder 51 can be avoided. For example, the transport device 1013 transports the preceding sample rack 5 in the above mentioned first direction, while the container sensor unit identifies the sample containers held on the subsequent sample rack. In other words, the direction of transporting the preceding sample rack is the same as the direction of the sample containers lined up on the subsequent sample rack, and the transport device 1013 can perform the processing of transporting the preceding sample rack 5 and the processing of identifying the sample containers 52 held on the subsequent sample rack 5 in parallel. Further, by integrating the transport device 1013 and the container sensor unit (container identifying device 1014 and the container type determining device 1015), space saving can be implemented.
<Sampling Control>
The processor 211 is an arithmetic unit, such as a central processing unit (CPU), and performs processing according to this embodiment by executing a program. The example in
The storage device 212 is a main storage device, such as a random access memory (RAM) and a read only memory (ROM), or an auxiliary storage device, such as a hard disk (HDD), a solid-state drive (SSD), an embedded multi-media card (eMMC), and a flash memory. The main storage device secures a work area for the processor 211, and temporarily stores data outputted by the sensors. The auxiliary storage device stores a program according to this embodiment, data outputted by the sensors, and other data. It is assumed that the identification information indicated on each sample container 52 and order information that links the sample contained in the sample container 52 and measurement to be performed for this sample are stored in the storage device 212 in advance by operation by the user, or by data transmission/reception via a network or the like.
In a case where it is determined that the sample rack 5 exists (S1: YES), on the other hand, the identification processing unit 2113 identifies at least one of: the identification information attached to the sample rack 5, the identification attached to each sample container 52 held on the sample rack 5; and the type of each sample container 52 (
At the same time, the identification processing unit 2113 determines the type of each sample container 52 using the container type determining device 1015. The container type determining device 1015 determines the type of each sample container 52 held on the sample rack 5 based on the height of the sample container 52. The container identifying device 1014 and the container type determining device 1015 are connected to the transport device 1013 at a distance equivalent to a number of holders 51 of the sample rack 5, for example, so that the container identifying device 1014 reads identification information of a certain sample container 52, while the container type determining device 1015 determines a type of a sample container 52 that is distant from the above sample container 52 by a predetermined number of holders 51.
In a case where the identification information on a sample container 52 held in a certain holder 51 is successfully read, and/or in a case where the container type of the sample container 52 is specified, it may be determined that a sample container exists in this holder 51, and this holder 51 may become a target of the sampling processing in the later mentioned processing steps. For example, on a sample cup or the like containing a sample, such identification information as a barcode is attached and read by the container identifying device 1014. On the other hand, an additional cup or the like for mixing the sample, on which identification information is not attached, is carried onto the table 101 in an empty state, and a sample or the like is dispensed into this cup by the sample nozzle unit 103 in the sampling processing. Therefore in a case where the order information, which is inputted to the computer 21 separately, indicates that a sample container to be carried in is a sample container without an additional cup, the identification processing unit 2113 determines that a sample container exists if the identification information on the sample container 52 is successfully read and the container type is specified as a sample container based on the information acquired from the container sensor unit (container identifying device 1014 and container type determining device 1015). In a case where the order information indicates that a sample container to be carried in is an additional cup, the identification processing unit 2113 determines that a sample container exists if the container type is specified as the additional cup based on the information acquired from the container sensor unit.
The device control unit 2111 operates the carry-in device 1018 and the transport device 1013, and carries the sample rack 5 into the sampling lane (
The identification processing unit 2113 also determines whether a subsequent sample rack 5 exists on the table 101 based on the data acquired by the data acquisition unit 2112 (
In a case where a subsequent sample rack 5 exists (S4: YES), the device control unit 2111 operates the transport device 1013 and transports the preceding sample rack 5, while the identification processing unit 2113 identifies the identification information attached on the subsequent sample rack 5, the identification information attached on each sample container 52 held on the sample rack 5, and the type of each sample container 52 based on the information acquired from the container sensor unit (
Specifically,
In a case where a subsequent sample rack 5 does not exist in S4 (S4: NO), on the other hand, the device control unit 2111 operates the transport device 1013 and transports 5 the preceding sample rack 5 (
The device control unit 2111 dispenses a sample from each sample container 52 held on the preceding sample rack 5 to the cuvette (
Then the device control unit 2111 operates the carry-out device 1019 and carries out the preceding sample rack 5 (
In the case where it is determined that the information has already been identified (S9: YES), processing returns to S3, and the subsequent sample rack 5 is carried onto the sampling lane. On the other hand, in the case where it is determined that the information on the subsequent sample rack 5 has not yet been identified (S9: NO), processing returns to S1, and it is determined whether a new sample rack 5 is placed. As described above, the analyzing device 1000 consecutively executes the processing of carrying the sample rack 5, to be placed on the table 101, onto the sampling lane, and performing sampling.
<Effect>
According to this embodiment, in the case where a plurality of sample racks 5 are consecutively carried into the measuring device 1000, the processing of transporting the preceding sample rack 5 on the sampling lane and the processing of identifying the subsequent sample rack 5 and sample containers 52 held on this sample rack 5 are performed in parallel in S5 in
<Other>
The embodiments and modifications described above are merely examples, and the present invention is not limited to the above mentioned configurations.
The content described in the embodiment may be changed within a scope that does not depart from the problem and technical spirit of the present invention.
The present invention includes: a method and a computer program to execute the above mentioned processing, and a computer-readable recording medium in which this program is recorded. The above mentioned processing is performed by the computer executing the program recorded in the recording medium.
Here the computer-readable recording medium refers to a recording medium that can store information, such as data and a program, by electrical, magnetic, optical, mechanical or chemical operation, and the recording medium can be read by a computer. Among such recording media, examples of a recording medium that is detachable from a computer are a flexible disk, a magneto-optical disk, an optical disk, a magnetic tape and a memory card. Examples of a recording medium that is embedded in the computer are an HDD, a solid-state drive (SSD), a ROM, and the like.
Number | Date | Country | Kind |
---|---|---|---|
2019-076682 | Apr 2019 | JP | national |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/JP2020/015848 | 4/8/2020 | WO | 00 |