Patent Application
20240192240
This application is based upon and claims the benefit of priority from the prior Japanese Patent Application No. 2022-196479, filed on Dec. 8, 2022, the entire contents of which are incorporated herein by reference.
Embodiments described in the present specification and drawings relate generally to a transport rack, an automatic analyzing apparatus, and an automatic analyzing system.
An automatic analyzing apparatus is an apparatus that analyzes a component of a test sample corresponding to each test item by, for example, optically measuring a mixed liquid obtained by mixing a sample such as a test sample collected from a subject such as blood or a standard sample of each test item with a reagent corresponding to each test item.
In the related art, in the automatic analyzing apparatus, liquid level detection of a sample is performed at the time of sampling. In the liquid level detection of the sample, it is determined whether or not a tip of a dispensing probe comes into contact with a liquid level by detecting a change in electrostatic capacitance of the dispensing probe. However, in a method for detecting the liquid level by the change in electrostatic capacitance, the automatic analyzing apparatus may erroneously detect, as the liquid level, an air bubble generated on a sample surface. Then, in a case where the air bubble is erroneously detected as the liquid level, since the automatic analyzing apparatus performs sampling at a position where the air bubble is detected, the sample is not sucked and the sample cannot be dispensed normally. In addition, in the method for detecting the liquid level by the change in electrostatic capacitance, in a case where a storage container that stores the sample is empty or in a case where the amount of sample necessary for a test is not stored in the storage container, an error may occur at a sampling stage, and one step may be wasted. Thus, it is desired to enable observation of the liquid level of the sample before sampling in the automatic analyzing apparatus.
However, although a slit for reading identification information on the storage container is provided in a transport rack of the related art that transports the storage container, a slit or an opening is not provided in a surface opposite to the surface in which the slit is provided. Thus, in a case where the liquid level is observed from the slit for reading the identification information on the storage container, the liquid level of the sample stored in the storage container is hidden by the identification information on the storage container, and the automatic analyzing apparatus cannot observe the liquid level. In order to solve this problem, there is also a technique of rotating the storage container stored in the transport rack. However, in a case where the identification information is read and the liquid level of the sample is observed by using this technique, since it is necessary to rotate the storage container to observe the liquid level of the sample after reading the identification information, an operation becomes complicated and a time is required. In addition, these problems similarly occur not only in the sample stored in the storage container transported by the transport rack but also in the reagent stored in the storage container transported by the transport rack. Thus, in the automatic analyzing apparatus, it is desired, before sampling, to read the identification information and to enable observation of the liquid level of the sample or the liquid level of the reagent.
Hereinafter, respective embodiments of the transport rack, the automatic analyzing apparatus, and the automatic analyzing system will be described with reference to the accompanying drawings. In the embodiments below, the same reference signs are given for identical components in terms of configuration and function, and duplicate description is omitted.
The analysis mechanism 2 adds to the sample a reagent used for each test item set in a sample such as a standard sample or a test sample. The analysis mechanism 2 measures a mixed liquid obtained by adding the reagent to the sample, and generates, for example, standard data and test data. In the present embodiment, the standard data represents measurement data of absorbance for a standard sample whose concentration of a detection target to be included is known. In addition, the test data represents measurement data of absorbance for the test sample. Note that, in the following description, in a case where the standard sample and the test sample are expressed without distinction, these samples may be simply referred to as a “sample”.
The analysis circuitry 3 is a processor that generates calibration data, analysis data, and the like by analyzing the standard data and the test data generated by the analysis mechanism 2. The analysis circuitry 3 reads an analysis program from the memory 8, and generates calibration data, analysis data, and the like according to the read analysis program. For example, the analysis circuitry 3 generates calibration data indicating a relationship between the standard data and a standard value set in advance for the standard sample based on the standard data. In addition, the analysis circuitry 3 generates analysis data represented as a concentration value and an activity value of an enzyme based on test data and calibration data of a test item corresponding to the test data. The analysis circuitry 3 outputs the generated calibration data, analysis data, and the like to the control circuitry 9.
The drive mechanism 4 drives the analysis mechanism 2 under the control of the control circuitry 9. For example, the drive mechanism 4 is realized by a gear, a stepping motor, a belt conveyor, a lead screw, and the like.
The input interface 5 receives setting of an analysis parameter or the like of each test item related to a sample requested to be measured from a user or via an in-hospital network NW, for example. The input interface 5 is realized by, for example, a mouse, a keyboard, a touch pad to which an instruction is input by touching an operation surface, and the like. The input interface 5 is connected to the control circuitry 9, converts an operation instruction input from the user into an electric signal, and outputs the electric signal to the control circuitry 9. Note that, in the present embodiment, the input interface 5 is not limited to the interface including physical operation components such as a mouse and a keyboard. For example, an electric signal processing circuitry that receives an electric signal corresponding to an operation instruction input from an external input device provided separately from the automatic analyzing apparatus 1 and outputs the electric signal to the control circuitry 9 is also included in the example of the input interface 5.
The output interface 6 is connected to the control circuitry 9 and outputs a signal supplied from the control circuitry 9. The output interface 6 is realized by, for example, a display circuitry, a print circuitry, an audio device, and the like. Examples of the display circuitry include a CRT display, a liquid crystal display, an organic EL display, an LED display, and a plasma display. Note that, the display circuitry also includes a processing circuitry that converts data representing a display target into a video signal and outputs the video signal to the outside. The print circuitry includes, for example, a printer. Note that, an output circuitry that outputs data representing a printing target to an outside is also included in the print circuitry. The audio device includes, for example, a speaker. Note that, an output circuitry that outputs an audio signal to the outside is also included in the audio device.
The communication interface 7 is connected to, for example, the in-hospital network NW, and connects the automatic analyzing apparatus 1 to the in-hospital network NW. The communication interface 7 performs data communication with a hospital information system (HIS) via the in-hospital network NW. Note that, the communication interface 7 may perform data communication with the HIS via a laboratory information system (LIS) connected to the in-hospital network NW.
The memory 8 includes a magnetic or optical recording medium, a recording medium readable by a processor, such as a semiconductor memory, or the like. Note that, the memory 8 is not necessarily realized by a single memory device. For example, the memory 8 can be realized by a plurality of memory devices.
In addition, the memory 8 stores an analysis program executed by the analysis circuitry 3 and a control program executed by the control circuitry 9. The memory 8 stores the analysis data generated by the analysis circuitry 3 for each test item. The memory 8 stores test information input from an operator or test information received by the communication interface 7 via the in-hospital network NW. The test information includes information such as a sample ID, a test item required for a sample to be measured, a measurement order related to the test, and the amount of dispensed sample or reagent necessary for the test. Note that, although the test information according to the present embodiment includes the information such as the sample ID, the test item required for the sample to be measured, the measurement order related to the test, and the amount of dispensed sample or reagent necessary for the test, the test information is not limited to these pieces of information. That is, the information included in the test information is any information. The sample ID is an example of identification information in the present embodiment.
In addition, the memory 8 stores observation result information which is an observation result of the sample or the reagent stored in a storage container held by a transport rack to be described later. The observation result information includes, for example, liquid level positional information regarding a liquid level position of the sample or a liquid level position of the reagent stored in the storage container, color information regarding color of the sample or color of the reagent stored in the storage container, liquid level state information regarding a liquid level state of the sample or a liquid level state of the reagent stored in the storage container, and shape information regarding a shape such as a diameter of the storage container. Note that, although the observation result information according to the present embodiment includes the liquid level positional information, the color information, and the liquid level state information, the observation result information is not limited to these pieces of information. That is, the information included in the observation result information is any information.
Further, the memory 8 stores storage amount information regarding the amount of sample or the amount of reagent stored in the storage container. The storage amount information is calculated based on the liquid level positional information, the shape information, and the like in the observation result information.
The control circuitry 9 is a processor that functions as a center of the automatic analyzing apparatus 1. The control circuitry 9 is an example of a processing circuitry. The control circuitry 9 realizes a function corresponding to the operation program by executing the operation program stored in the memory 8. Note that, the control circuitry 9 may include a memory area that stores at least part of the data stored in the memory 8.
The reaction disk 201 holds a plurality of reaction containers 2011 arrayed in a ring shape. The reaction disk 201 transports the plurality of reaction containers 2011 along a predetermined path. Specifically, during an analysis operation of the mixed liquid of the sample and the reagent, the reaction disk 201 is alternately rotated and stopped at predetermined time intervals by the drive mechanism 4. The reaction container 2011 is made of, for example, glass, polypropylene (PP), or acrylic.
The thermostatic unit 202 stores a heating medium set at a predetermined temperature. The thermostatic unit 202 raises a temperature of the mixed liquid stored in the reaction container 2011 to a predetermined temperature and maintains the mixed liquid to be warm by immersing the reaction container 2011 in the stored heat medium.
The rack sampler 203 supports the transport rack 22 capable of holding storage containers 21 in a transportable manner. The storage container 21 stores a sample such as blood requested to be measured, a reagent to react with the sample, or the like. A label is attached to the storage container 21. An optical mark representing identification information of the sample or the reagent stored in the storage container 21 is printed on the label. For example, any pixel code such as a one-dimensional pixel code and a two-dimensional pixel code is used as the optical mark.
Note that, in the example illustrated in
A transport area 2031 for transporting the transport rack 22 is provided in the rack sampler 203. That is, the transport rack 22 is transported from the feeding position where the transport rack 22 is fed to the collecting position where the transport rack 22 whose measurement is completed is collected by using the transport area 2031.
In the present embodiment, in the transport area 2031, the transport rack 22 fed from the feeding position is transported to a dispensing standby position before being transported to a dispensing position by the drive mechanism 4, for example. The dispensing position is a position where suction of the sample or suction of the reagent is performed. The dispensing standby position is a position where the storage container 21 is on standby for dispensing of the sample or dispensing of the reagent, and is provided, for example, on a movement trajectory of the storage container 21 held by the transport rack 22 supported by the rack sampler 203. In addition, in the transport area 2031, in a case where the suction of the sample or the suction of the reagent is performed, the transport rack 22 at the dispensing standby position is transported to the dispensing position by the drive mechanism 4. This dispensing position is provided, for example, at a position where a rotation trajectory of the sample dispensing probe 207 and a movement trajectory of an opening of the storage container 21 supported by the rack sampler 203 and held by the transport rack 22 intersect. Then, in the transport area 2031, after the sample or the reagent stored in the storage container 21 is dispensed, the transport rack 22 at the dispensing position is transported to a collecting position by the drive mechanism 4.
A configuration of the transport rack 22 used in the analysis mechanism 2 in the present embodiment will be described in detail with reference to
The holder 2201 holds the storage container 21 in which the sample or the reagent is stored. As illustrated in
The transport arm connection unit 2202 is connected to a transport arm (not illustrated) provided in the analysis mechanism 2 in order to transport the transport rack 22 to a predetermined position. As illustrated in
The first observation window 2203 is an observation window that enables reading of identification information present in the storage container 21 held by the holder 2201. As illustrated in
The second observation window 2204 is an observation window that enables observation of the sample or the reagent stored in the storage container 21 held by the holder 2201. As illustrated in
In addition, as illustrated in
Note that, although the first slit 2203_1 of the first observation window 2203 and the second slit 2204_1 of the second observation window 2204 according to the present embodiment each have the tapered shape, these slits may not necessarily have the tapered shape. That is, the first slit 2203_1 and the second slit 2204_1 may each have a linear shape from the holder 2201 toward each side surface of the transport rack 22, and at least one of the first slit 2203_1 and the second slit 2204_1 may have the tapered shape.
The transport rack 22 and the automatic analyzing apparatus 1 that analyzes the sample by measuring a component in the sample by using the sample or the reagent stored in the storage container 21 held by the transport rack 22 constitute an automatic analysis system according to the present embodiment.
The first reagent storage 204 cools a plurality of reagent containers storing a first reagent that reacts with a predetermined component contained in the standard sample and the test sample. The first reagent is, for example, a buffer solution containing bovine serum albumin (BSA) or the like. A reagent label is attached to the reagent container. An optical mark representing reagent information is printed on the reagent label. For example, any pixel code such as a one-dimensional pixel code and a two-dimensional pixel code is used as the optical mark. The reagent information is information regarding the reagent contained in the reagent container, and includes, for example, a reagent name, a reagent manufacturer code, a reagent item code, a bottle type, a bottle size, a volume, a production lot number, a valid period, and the like.
In addition, the first reagent storage 204 keeps cool a plurality of standard sample containers storing standard samples. Each of the plurality of standard sample containers contains a standard sample of the same component having different concentrations. Note that, the standard sample containers may be held by the transport rack 22.
A reagent rack 2041 is rotatably provided in the first reagent storage 204. The reagent rack 2041 holds a plurality of reagent containers and a plurality of standard sample containers arrayed in an annular shape. The reagent rack 2041 is rotated by the drive mechanism 4. In addition, a reader (not illustrated) that reads reagent information from a reagent label attached to the reagent container is provided in the first reagent storage 204. The read reagent information is stored in the memory 8.
A first reagent suction position is set at a predetermined position on the first reagent storage 204. The first reagent suction position is provided, for example, at a position where a rotation trajectory of the first reagent dispensing probe 209 and a movement trajectory of openings of the reagent container and the standard sample container annularly arrayed in the reagent rack 2041 intersect.
The second reagent storage 205 keeps cool a plurality of reagent containers storing a second reagent paired with the first reagent of two reagent systems. The second reagent is a solution containing an insoluble carrier, for example, a carrier particle, on which a predetermined antigen or antibody contained in the sample and an antigen or antibody bound or separated by a specific antigen-antibody reaction are immobilized. An enzyme, a substrate, an aptamer, or a receptor may be bound or separated by a specific reaction. In the second reagent storage 205, a reagent rack 2051 is rotatably provided.
The reagent rack 2051 holds a plurality of reagent containers arrayed in an annular shape. Note that, the standard sample container storing the standard sample may be kept cool in the second reagent storage 205. The reagent rack 2051 is rotated by the drive mechanism 4. In addition, in the second reagent storage 205, a reader (not illustrated) that reads reagent information from a reagent label attached to the reagent container is provided. The read reagent information is stored in the memory 8.
A second reagent suction position is set at a predetermined position on the second reagent storage 205. The second reagent suction position is provided, for example, at a position where a rotation trajectory of the second reagent dispensing probe 211 and a movement trajectory of openings of the reagent containers annularly arrayed in the reagent rack 2051 intersect.
The sample dispensing arm 206 is provided between the reaction disk 201 and the rack sampler 203. The sample dispensing arm 206 is provided to be movable up and down in a vertical direction and to be rotatable in a horizontal direction by the drive mechanism 4. The sample dispensing arm 206 holds the sample dispensing probe 207 at one end.
The sample dispensing probe 207 rotates along an arc-shaped rotation trajectory along with the rotation of the sample dispensing arm 206. A dispensing position is provided on the movement trajectory. In addition, a sample discharge position for discharging the sample sucked by the sample dispensing probe 207 to the reaction container 2011 is provided on the rotation trajectory of the sample dispensing probe 207. The sample discharge position is provided at a position where the rotation trajectory of the sample dispensing probe 207 and a movement trajectory of the reaction container 2011 held by the reaction disk 201 intersect.
The sample dispensing probe 207 is driven by the drive mechanism 4 and moves in an up and down direction at the dispensing position or the sample discharge position. In addition, the sample dispensing probe 207 sucks the sample from the storage container 21 at the dispensing position under the control of the control circuitry 9. In addition, the sample dispensing probe 207 discharges the sucked sample to the reaction container 2011 positioned immediately below the sample discharge position under the control of the control circuitry 9.
In addition, in the present embodiment, in a case where the reagent is stored in the storage container 21 held by the transport rack 22, the sample dispensing probe 207 sucks the reagent stored in the storage container 21 and discharges the reagent to the reaction container 2011. Specifically, the sample dispensing probe 207 sucks the reagent from the storage container 21 positioned immediately below at the dispensing position under the control of the control circuitry 9. In addition, the sample dispensing probe 207 discharges the sucked reagent to the reaction container 2011 positioned immediately below the sample discharge position under the control of the control circuitry 9. The sample dispensing probe 207 is a dispensing probe in the present embodiment.
The first reagent dispensing arm 208 is provided in the vicinity of an outer periphery of the first reagent storage 204. The first reagent dispensing arm 208 is provided to be movable up and down in the vertical direction and to be rotatable in the horizontal direction by the drive mechanism 4. The first reagent dispensing arm 208 holds the first reagent dispensing probe 209 at one end.
The first reagent dispensing probe 209 rotates along an arc-shaped rotation trajectory along with the rotation of the first reagent dispensing arm 208. The first reagent suction position is provided on the rotation trajectory. In addition, a first reagent discharge position for discharging the first reagent or the standard sample sucked by the first reagent dispensing probe 209 to the reaction container 2011 is set on the rotation trajectory of the first reagent dispensing probe 209. The first reagent discharge position is provided at a position where the movement trajectory of the first reagent dispensing probe 209 and the movement trajectory of the reaction container 2011 held by the reaction disk 201 intersect.
The first reagent dispensing probe 209 is driven by the drive mechanism 4 and moves in the up and down direction at the first reagent suction position or the first reagent discharge position on the rotation trajectory. In addition, the first reagent dispensing probe 209 sucks the first reagent or the standard sample from the reagent container positioned immediately below the first reagent suction position under the control of the control circuitry 9. In addition, the first reagent dispensing probe 209 discharges the sucked first reagent or standard sample to the reaction container 2011 positioned immediately below the first reagent discharge position under the control of the control circuitry 9.
The second reagent dispensing arm 210 is provided in the vicinity of the outer periphery of the first reagent storage 204. The second reagent dispensing arm 210 is provided to be movable up and down in the vertical direction and to be rotatable in the horizontal direction by the drive mechanism 4. The second reagent dispensing arm 210 holds the second reagent dispensing probe 211 at one end.
The second reagent dispensing probe 211 rotates along an arc-shaped rotation trajectory along with the rotation of the second reagent dispensing arm 210. The second reagent suction position is provided on the rotation trajectory. In addition, a second reagent discharge position for discharging the second reagent sucked by the second reagent dispensing probe 211 to the reaction container 2011 is set on the rotation trajectory of the second reagent dispensing probe 211. The second reagent discharge position is provided at a position where the movement trajectory of the second reagent dispensing probe 211 and the movement trajectory of the reaction container 2011 held by the reaction disk 201 intersect.
The second reagent dispensing probe 211 is driven by the drive mechanism 4 and moves in the up and down direction at the second reagent suction position or the second reagent discharge position on the rotation trajectory. In addition, the second reagent dispensing probe 211 sucks the second reagent from the reagent container positioned immediately below the second reagent suction position under the control of the control circuitry 9. In addition, the second reagent dispensing probe 211 discharges the sucked second reagent to the reaction container 2011 positioned immediately below the second reagent discharge position under the control of the control circuitry 9. As can be seen from this, the second reagent dispensing arm 210 and the second reagent dispensing probe 211 constitute a second reagent dispensing device according to the present embodiment.
The first stirring unit 212 is provided in the vicinity of an outer periphery of the reaction disk 201. The first stirring unit 212 includes a first stirring arm 2121 and also includes a first stirring bar provided at a tip of the first stirring arm 2121. The first stirring unit 212 stirs, by the first stirring bar, the mixed liquid of the standard sample and the first reagent stored in the reaction container 2011 positioned at a first stirring position on the reaction disk 201. In addition, the first stirring unit 212 stirs, by the first stirring bar, the mixed liquid of the test sample and the first reagent stored in the reaction container 2011 positioned at the first stirring position on the reaction disk 201.
The second stirring unit 213 is provided in the vicinity of the outer periphery of the reaction disk 201. The second stirring unit 213 includes a second stirring arm 2131 and also includes a second stirring bar provided at a tip of the second stirring arm 2131. The second stirring unit 213 stirs, by the second stirring bar, the mixed liquid of the standard sample, the first reagent, and the second reagent stored in the reaction container 2011 positioned at a second stirring position on the reaction disk 201. In addition, the second stirring unit 213 stirs, by the second stirring bar, the mixed liquid of the test sample, the first reagent, and the second reagent stored in the reaction container 2011 positioned at the second stirring position.
The photometric unit 214 optically measures a reaction liquid of the sample, the first reagent, and the second reagent discharged into the reaction container 2011. The photometric unit 214 includes a light source and a photodetector. The photometric unit 214 emits light from the light source under the control of the control circuitry 9. The emitted light is incident from a first sidewall of the reaction container 2011 and is emitted from a second sidewall facing the first side wall. The photometric unit 214 detects the light emitted from the reaction container 2011 by the photodetector.
Specifically, for example, the photodetector is disposed at a position on an optical axis of the light emitted from the light source to the reaction container 2011. The photodetector detects light transmitted through a reaction liquid of the standard sample, the first reagent, and the second reagent in the reaction container 2011, and generates standard data represented by absorbance based on intensity of the detected light. In addition, the photodetector detects light transmitted through a reaction liquid of the test sample, the first reagent, and the second reagent in the reaction container 2011, and generates test data represented by absorbance based on intensity of the detected light. The photometric unit 214 outputs, as a measurement result, the generated standard data and test data to the analysis circuitry 3.
The cleaning unit 215 cleans the inside of the reaction container 2011 in which the measurement of the reaction liquid is ended by the photometric unit 214.
The reading unit 216 reads the identification information via the first observation window 2203 that enables reading of the identification information on the storage container 21 held by the transport rack 22 that transports the storage container 21 that stores the sample or the reagent, and reads the observation result information that is the observation result of the sample or the reagent stored in the storage container 21 held by the transport rack 22 via the second observation window 2204 that enables observation of the sample or the reagent stored in the storage container 21. The reading unit 216 corresponds to an information reader in the present embodiment.
A configuration of the reading unit 216 according to the present embodiment will be described in detail with reference to
The first imaging device 2161 reads the identification information on the storage container 21 by reading the optical mark on the storage container 21 via the first slit 2203_1 of the first observation window 2203. As illustrated in
In addition, the second imaging device 2162 reads observation result information that is an observation result of the sample or the reagent stored in the storage container 21 via the second slit 2204_1 of the second observation window 2204. As illustrated in
Note that, although the reading unit 216 illustrated in
In addition, in the automatic analyzing apparatus 1 according to the present embodiment described above, although the reading unit 216 is configured by providing the imaging device for each of the first observation window 2203 and the second observation window 2204, the imaging device may not be necessarily provided for each of the first observation window 2203 and the second observation window 2204. That is, the reading unit 216 may be configured by providing one imaging device.
As illustrated in
The imaging device 2163 reads the identification information via the first slit 2203_1 of the first observation window 2203 and reads the observation result information via the second slit 2204_1 of the second observation window 2204. In the example illustrated in
In order for the imaging device 2163 to read the identification information via the first slit 2203_1 of the first observation window 2203, the first mirror 2164 is provided at a position facing the first slit 2203_1 of the first observation window 2203. In addition, the first mirror 2164 forms a first optical path 2164_1 between the first slit 2203_1 of the first observation window 2203 and the imaging device 2163. In the example illustrated in
In order for the imaging device 2163 to read the observation result information via the second slit 2204_1 of the second observation window 2204, the second mirror 2165 is provided at a position facing the second slit 2204_1 of the second observation window 2204, and forms a second optical path 2165_1 between the second slit 2204_1 of the second observation window 2204 and the imaging device 2163. In the example illustrated in
Note that, although the first mirror 2164 and the second mirror 2165 are provided at an angle inclined by 45° with respect to the horizontal plane, the angle at which the first mirror 2164 and the second mirror 2165 are provided is not limited thereto. That is, the angle at which the first mirror 2164 and the second mirror 2165 are provided is any angle according to the position of the imaging device 2163.
As illustrated in
In the control circuitry 9 illustrated in
The control function 91 is a function of integrally controlling the units in the automatic analyzing apparatus 1 based on input information input from the input interface 5. For example, the control function 91 controls the drive mechanism 4 and the analysis mechanism 2 in the control circuitry 9, and controls the analysis circuitry 3 so as to perform analysis corresponding to the test item. Specifically, the control function 91 controls the sample dispensing probe 207 based on the identification information and the observation result information read by the reading unit 216.
The image analysis function 92 analyzes image data to generate various kinds of information. For example, the image analysis function 92 is a function of analyzing the image data generated by the reading unit 216 in the control circuitry 9 to generate the observation result information and the identification information.
The calculation function 93 is a function of calculating the storage amount information regarding the amount of sample or the amount of reagent stored in the storage container 21 based on the observation result information read by the reading unit 216. For example, the calculation function 93 calculates the storage amount information regarding the amount of sample or the amount of reagent stored in the storage container 21 based on the shape information and the liquid level positional information included in the observation result information.
The determination function 94 is a function of determining whether or not there is the amount of sample necessary for test in the storage container 21 based on the test information and the storage amount information calculated by the calculation function 93. In addition, the determination function 94 is a function of determining whether or not a state of the sample or a state of the reagent stored in the storage container 21 is in a predetermined state based on the color information included in the observation result information. For example, in a case where the sample is serum or plasma, the state of the sample being in the predetermined state is a state where chyle, jaundice, hemolysis, or the like occurs in the sample, and chyle, jaundice, hemolysis, or the like occurs to such an extent that the sample cannot be measured, or a state where chyle, jaundice, hemolysis, or the like occurs to such an extent that the measurement result is affected, or the like. In addition, the state of the reagent being in the predetermined state is a state where a change in color tone, turbidity, or the like occurs in the reagent and the reagent cannot be used for measurement, or a state where a change in color tone, turbidity, or the like occurs to such an extent that the measurement result is affected, or the like.
In a case where the determination function 94 determines that there is not the amount of sample or the amount of reagent necessary for the test in the storage container 21, the first notification function 95 is a function of notifying that the amount of sample or the amount of reagent is insufficient. For example, the first notification function 95 notifies the user that the amount of sample is insufficient via the output interface 6.
The second notification function 96 is a function of notifying that the liquid level of the sample or the liquid level of the reagent stored in the storage container 21 is not detected. For example, the second notification function 96 notifies the user that the liquid level of the sample or the liquid level of the reagent is not detected via the output interface 6.
Note that, the control function 91, the image analysis function 92, the calculation function 93, the determination function 94, the first notification function 95, and the second notification function 96 illustrated in
As illustrated in
On the other hand, in a case where the storage container 21 is present at the dispensing standby position (step S11: Yes), as illustrated in
Subsequently, as illustrated in
Subsequently, as illustrated in
Subsequently, as illustrated in
Subsequently, as illustrated in
The reading processing illustrated in
As illustrated in
On the other hand, in step S31, in a case where the storage container 21 is present at the dispensing position (step S31: Yes), the automatic analyzing apparatus 1 acquires the test information (step S33). The processing of acquiring the test information is realized by the control function 91 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 acquires the test information stored in the memory 8 based on the identification information on the storage container 21 read in the reading processing.
Subsequently, as illustrated in
Then, in a case where there is not the observation result information and the storage amount information (step S35: No), the sample dispensing probe 207 is lowered (step S37). The processing of lowering the sample dispensing probe 207 is realized by the control function 91 in the control circuitry 9. Specifically, at the dispensing position, the automatic analyzing apparatus 1 lowers the sample dispensing probe 207 to a suction position in the vicinity of the liquid level of the sample or the liquid level of the reagent stored in the storage container 21.
Subsequently, as illustrated in
Then, in a case where the liquid level is not detected in step S39 (step S39: No), the automatic analyzing apparatus 1 notifies the user of a liquid level detection error (step S41). The processing of notifying the user of the liquid level detection error is realized by the second notification function 96 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 notifies, as the liquid level detection error, the user that the liquid level is not detected via the output interface 6.
On the other hand, in step S35, in a case where there are the observation result information and the storage amount information (step S35: Yes), the automatic analyzing apparatus 1 acquires the observation result information and the storage amount information (step S43). The processing of acquiring the observation result information and the storage amount information is realized by the control function 91 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 acquires the observation result information and the storage amount information stored in the memory 8.
Subsequently, as illustrated in
Then, in step S45, in a case where there is not the amount of sample or the amount of reagent necessary for the storage container 21 (step S45: No), the automatic analyzing apparatus 1 notifies the user that the amount of sample or the amount of reagent is insufficient (step S47). The processing of notifying the user that the amount of the sample or the amount of the reagent is insufficient is realized by the first notification function 95 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 notifies the user that the necessary amount of sample or reagent is insufficient via the output interface 6.
On the other hand, in a case where there is the amount of sample or the amount of reagent necessary for the storage container 21 in step S45 (step S45: Yes), the automatic analyzing apparatus 1 determines whether or not the state of the sample or the state of the reagent stored in the storage container 21 is a predetermined state (step S49). The processing of determining whether or not the state of the sample or the state of the reagent is the predetermined state is realized by the determination function 94 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 determines a type of the sample or a type of the reagent stored in the storage container 21 based on the color information in the observation result information acquired in step S45, and determines whether or not the state of the sample or the state of the reagent stored in the storage container 21 is the predetermined state.
Note that, although the type of the sample or the type of the reagent stored in the storage container 21 is determined in step S49, in a case where the type of the sample or the type of the reagent stored in the storage container 21 is determined from the test information or the like, in step S49, the automatic analyzing apparatus 1 determines whether or not the state of the sample or the state of the reagent stored in the storage container 21 is the predetermined state based on the test information acquired in step S33 and the color information in the observation result information acquired in step S45.
Then, in step S49, in a case where it is determined that the state of the sample or the state of the reagent is the predetermined state (step S49: Yes), the automatic analyzing apparatus 1 stops the dispensing (step S51). The processing of stopping the dispensing is realized by the control function 91 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 stops the dispensing of the sample or the reagent stored in the storage container 21 transported to the dispensing position.
On the other hand, in step S49, in a case where it is determined that the state of the sample or the state of the reagent is not the predetermined state (step S49: No), the automatic analyzing apparatus 1 lowers the sample dispensing probe 207 (step S53). The processing of lowering the sample dispensing probe 207 is realized by the control function 91 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 lowers the sample dispensing probe 207 based on the liquid level positional information in the observation result information acquired in step S43.
Subsequently, as illustrated in
Then, in step S55, in a case where the liquid level is not detected (step S55: No), the automatic analyzing apparatus 1 lowers the sample dispensing probe 207 by a predetermined amount (step S57). The processing of lowering the sample dispensing probe 207 by the predetermined amount is realized by the control function 91 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 lowers the sample dispensing probe 207 lowered in step S53 by the predetermined amount toward the liquid level. Here, the predetermined amount is, for example, an amount of 1 mm or the like, but the predetermined amount is not limited thereto. That is, the predetermined amount is any amount, and may be 1 mm or more and 1 mm or less.
Subsequently, as illustrated in
Note that, in step S39, step S55, and step S59, although the liquid level is detected by a change in electrostatic capacitance as a liquid level detection method, the liquid level detection method is not limited thereto. That is, the liquid level detection method in step S39, step S55, and step S59 is any method, and for example, the liquid level may be detected by a change in pressure, the liquid level may be detected by a change in resistance value, or the liquid level may be detected by using the first imaging device 2161 or the second imaging device 2162.
Then, in step S59, in a case where the liquid level is not detected (step S59: No), the automatic analyzing apparatus 1 determines whether or not the sample dispensing probe 207 is lowered a predetermined number of times (step S61). The processing of determining whether or not the sample dispensing probe 207 is lowered the predetermined number of times is realized by the control function 91 in the control circuitry 9. Then, in step S61, in a case where the number of times the sample dispensing probe 207 is lowered by the predetermined amount is less than a predetermined number of times, that is, in a case where the sample dispensing probe 207 is not lowered by the predetermined number of times (step S61: No), the automatic analyzing apparatus 1 returns to step S57, repeats the processing from step S57 to step S61, and is on standby. That is, the automatic analyzing apparatus 1 lowers the sample dispensing probe 207 by the predetermined amount again by the control function 91.
On the other hand, in a case where the number of times the sample dispensing probe 207 is lowered by the predetermined amount reaches the predetermined number of times in step S61, that is, in a case where the sample dispensing probe 207 is lowered by the predetermined number of times (step S61: Yes), the automatic analyzing apparatus 1 notifies the user of the liquid level detection error (step S63). The processing of notifying the user of the liquid level detection error is realized by the second notification function 96 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 notifies, as the liquid level detection error, the user that the liquid level is not detected via the output interface 6.
On the other hand, when the liquid level is detected in step S39, step S55, and step S59 (step S39, step S55, step S59: Yes), the automatic analyzing apparatus 1 sucks the sample or the reagent (step S65). The processing of sucking the sample or the reagent is realized by the control function 91 in the control circuitry 9. Specifically, the automatic analyzing apparatus 1 sucks the sample or the reagent stored in the storage container 21 transported to the dispensing position based on the test information acquired in step S33.
Subsequently, as illustrated in
Subsequently, as illustrated in
Subsequently, as illustrated in
Subsequently, as illustrated in
After this step S73, after step S41 described above, after step S47 described above, after step S51 described above, or after step S63 described above, as illustrated in
On the other hand, in step S75, in a case where the next storage container 21 is present at the dispensing position (step S75: Yes), the automatic analyzing apparatus 1 returns to step S33 and executes the processing from step S33.
The dispensing control processing illustrated in
As described above, in accordance with the automatic analyzing apparatus 1 according to the present embodiment, the transport rack 22 includes the holder 2201, the first observation window 2203, and the second observation window 2204, and thus, the reading unit 216 included in the automatic analyzing apparatus 1 reads the identification information on the storage container 21 held by the holder 2201 via the first observation window 2203 and reads the observation result information of the sample or the reagent stored in the storage container 21 held by the holder 2201 via the second observation window 2204 at the dispensing standby position. Accordingly, it is possible to read the identification information and observe the liquid level of the sample before sampling. That is, in the present embodiment, the transport rack 22 includes the first slit 2203_1 of the first observation window 2203 and the second slit 2204_1 of the second observation window 2204. The reading unit 216 reads the identification information via the first slit 2203_1 and reads the observation result information via the second slit 2204_1 at the dispensing standby position before being transported to the dispensing position where the suction of the sample or the reagent is performed. Accordingly, it is possible to observe the liquid level of the sample or the liquid level of the reagent while the identification information is read, and it is possible to prevent occurrence of a sampling error in advance.
In the automatic analyzing apparatus 1 according to the above-described first embodiment, although the first observation window 2203 in the transport rack 22 is configured by providing the first slit 2203_1 and the second observation window 2204 in the transport rack 22 is configured by providing the second slit 2204_1, the present invention is not limited thereto. In a second embodiment, a case where the transport rack 22 includes a transparent or translucent cover provided in at least one of the first slit 2203_1 and the second slit 2204_1 will be described. Hereinafter, portions different from the above-described first embodiment will be described. Note that, the configurations of the automatic analyzing apparatus 1 and the analysis mechanism 2 according to the first embodiment are similar to those in
In the second embodiment, the transport rack 22 used in the analysis mechanism 2 will be described in detail with reference to
The first observation window 2203 is an observation window that enables reading of identification information on the storage container 21 held by the holder 2201. As illustrated in
The second observation window 2204a is an observation window that enables observation of the sample or the reagent stored in the storage container 21 held by the holder 2201. As illustrated in
Note that, although the cover 2204_2 is provided by being attached to the second slit 2204_1, a method for providing the cover 2204_2 is not limited to the case of being attached to the second slit 2204_1. The cover 2204_2 may be provided by being fitted into a groove provided in the second slit 2204_1.
In addition, in the example illustrated in
In addition, although the first slit 2203_1 and the second slit 2204_1 have the linear shape from the holder 2201 toward each side surface, the present invention is not limited thereto. The first slit 2203_1 and the second slit 2204_1 may have a tapered shape expanding from the holder 2201 toward each side surface.
Further, although the cover is made of the transparent or translucent resin, the material of the cover is not limited thereto. That is, the material of the cover is any material.
As described above, in accordance with the automatic analyzing apparatus 1 according to the second embodiment, it is possible to read the identification information and observe the liquid level of the sample before sampling as in the above-described first embodiment. That is, in the present embodiment, the transport rack 22 includes the first slit 2203_1 of the first observation window 2203 and the second slit 2204_1 of the second observation window 2204a, and includes the transparent or translucent cover in at least one of the first slit 2203_1 and the second slit 2204_1. The reading unit 216 reads the identification information via the first observation window 2203 and reads the observation result information via the second observation window 2204a at the dispensing standby position before being transported to the dispensing position where the suction of the sample or the reagent is performed. Accordingly, it is possible to observe the liquid level of the sample or the liquid level of the reagent while reading the identification information, and it is possible to prevent the occurrence of the sampling error in advance.
In addition, in accordance with the automatic analyzing apparatus 1 of the present embodiment, since the cover is provided in at least one of the first slit and the second slit, it is possible to improve the strength of the transport rack 22.
In the automatic analyzing apparatus 1 according to the above-described first embodiment, although the first observation window 2203 in the transport rack 22 is configured by providing the first slit 2203_1, and the second observation window 2204 in the transport rack 22 is configured by providing the second slit 2204_1, the present invention is not limited thereto. In a third embodiment, a case where the first observation window 2203 and the second observation window 2204 are configured by forming, with a transparent or translucent material, one housing of a first housing in which the first observation window 2203 is provided and a second housing in which the second observation window is provided in the transport rack 22 and by providing slits in a side surface of the other housing of the first housing in which the first observation window 2203 is provided and the second housing in which the second observation window 2204 is provided will be described. Hereinafter, portions different from the above-described first embodiment will be described. Note that, the configurations of the automatic analyzing apparatus 1 and the analysis mechanism 2 according to the first embodiment are similar to those in
In the third embodiment, the transport rack 22 used in the analysis mechanism 2 will be described in detail with reference to
The holder 2201 holds the storage container 21 in which the sample or the reagent is stored. As illustrated in
The first observation window 2203 is an observation window that enables reading of identification information on the storage container 21 held by the holder 2201. As illustrated in
The second observation window 2204b is an observation window that enables observation of the sample or the reagent stored in the storage container 21 held by the holder 2201. In addition, as illustrated in
Note that, in the examples illustrated in
In addition, although the first housing 223 and the second housing 224 are formed with transparent or translucent resin, the materials of the first housing 223 and the second housing 224 are not limited thereto. That is, the material of the first housing 223 and the second housing 224 is any material, and may be, for example, a material such as transparent or translucent glass.
As described above, in accordance with the automatic analyzing apparatus 1 according to the third embodiment, it is possible to read the identification information and observe the liquid level of the sample before sampling as in the above-described first embodiment. That is, in the present embodiment, the transport rack 22 is configured by coupling the first housing 223 and the second housing 224, and the first observation window 2203 and the second observation window 2204 are configured by forming, with the transparent or translucent material, one housing of the first housing 223 and the second housing 224 and by providing the slits in the side surface of the other housing of the first housing 223 and the second housing 224. The reading unit 216 reads the identification information via the first observation window 2203 and reads the observation result information via the second observation window 2204 at the dispensing standby position. Accordingly, it is possible to observe the liquid level of the sample or the liquid level of the reagent while the identification information is read, and it is possible to prevent the occurrence of the sampling error in advance.
In addition, in accordance with the automatic analyzing apparatus 1 according to the present embodiment, the first observation window 2203 and the second observation window 2204 are configured by forming, with the transparent or translucent material, one housing of the first housing 223 and the second housing 224, and thus, it is not necessary to provide the slit in one housing of the first observation window 2203 and the second observation window 2204, and it is possible to improve the strength of the transport rack 22.
In the automatic analyzing apparatus 1 according to the above-described third embodiment, although the first observation window 2203 or the second observation window 2204 is configured by forming, with the transparent or translucent material, one housing of the first housing 223 and the second housing 224 in the transport rack 22, the present invention is not limited thereto. In the transport rack 22, the holder 2201, the first observation window 2203, and the second observation window 2204 may be provided in a housing, and the first observation window 2203 and the second observation window 2204c may be configured by forming, with the transparent or translucent material, the housing.
In the automatic analyzing apparatus 1 according to the above-described first embodiment, although the first observation window 2203 in the transport rack 22 is configured by providing the first slit 2203_1, and the second observation window 2204 in the transport rack 22 is formed by providing the second slit 2204_1, the present invention is not limited thereto. In a fourth embodiment, a case where at least one of the first slit 2203_1 and the second slit 2204_1 in the transport rack 22 is provided so as not to reach the upper surface of the transport rack 22 will be described. Hereinafter, portions different from the above-described first embodiment will be described. Note that, the configurations of the automatic analyzing apparatus 1 and the analysis mechanism 2 according to the first embodiment are similar to those in
The transport rack 22 used in the analysis mechanism 2 in the fourth embodiment will be described in detail with reference to
The first observation window 2203 is an observation window that enables reading of identification information present in the storage container 21 held by the holder 2201. As illustrated in
The second observation window 2204c is an observation window that enables observation of the sample or the reagent stored in the storage container 21 held by the holder 2201. As illustrated in
Note that, in the example illustrated in
In addition, although the first slit 2203_1 and the second slit 2204_1 have the linear shape from the holder 2201 toward each side surface, the present invention is not limited thereto. The first slit 2203_1 and the second slit 2204_1 may have a tapered shape expanding from the holder 2201 toward each side surface.
As described above, in accordance with the automatic analyzing apparatus 1 according to the fourth embodiment, it is possible to read the identification information and observe the liquid level of the sample before sampling as in the above-described first embodiment. That is, in the present embodiment, the transport rack 22 includes the first slit 2203_1 of the first observation window 2203 and the second slit 2204_1 of the second observation window 2204c, at least one of the first slit 2203_1 and the second slit 2204_1 is provided so as not to reach the upper surface of the transport rack 22. The reading unit 216 reads the identification information via the first observation window 2203 and reads the observation result information via the second observation window 2204c at the dispensing standby position before being transported to the dispensing position where the suction of the sample or the reagent is performed. Accordingly, it is possible to observe the liquid level of the sample or the liquid level of the reagent while the identification information is read, and it is possible to prevent occurrence of a sampling error in advance.
In addition, in accordance with the automatic analyzing apparatus 1 of the present embodiment, at least one of the first slit 2203_1 and the second slit 2204_1 is provided so as not to reach the upper surface of the transport rack 22. That is, since the upper portion of at least one of the first slit 2203_1 and the second slit 2204_1 is connected, it is possible to improve the strength of the transport rack 22.
In the automatic analyzing apparatus 1 according to the first to fourth embodiments described above, the reading unit 216 may include a barcode reader instead of the first imaging device. That is, the reading unit 216 may read the identification information by the barcode reader via the first observation window 2203 and may read the observation result information by the second imaging device via the second observation window.
In addition, in the automatic analyzing apparatus 1 according to the first to fourth embodiments described above, the reading unit 216 may include barcode readers in addition to the first imaging device and the second imaging device. That is, the reading unit 216 may read the identification information by the first imaging device and/or the barcode reader via the first observation window 2203, and may read the observation result information by the second imaging device and/or the barcode reader via the second observation window 2204.
In addition, in the automatic analyzing apparatus 1 according to the first to fourth embodiments described above, after the reading unit 216 reads the identification information and the observation result information at the dispensing standby position, the automatic analyzing apparatus 1 transports the transport rack 22 to the dispensing position by the drive mechanism 4. However, the reading unit 216 may read the identification information and the observation result information at the dispensing position. That is, the reading unit 216 may read the identification information and the observation result information before sampling at the dispensing position, and may execute the dispensing control processing after reading the identification information and the observation result information.
In addition, in the automatic analyzing apparatus 1 according to the first to fourth embodiments described above, although the suction of the sample or the reagent stored in the storage container 21 is performed by the sample dispensing probe 207, the suction of the sample or the reagent stored in the storage container 21 is not limited to the sample dispensing probe 207. That is, the probe that sucks the sample or the reagent stored in the storage container 21 is any probe, and for example, may be performed by the first reagent dispensing probe 209, the second reagent dispensing probe 211, or the like at the dispensing position. Further, another dispensing probe other than the sample dispensing probe 207, the first reagent dispensing probe 209, and the second reagent dispensing probe 211 is provided, and thus, the suction of the sample stored in the storage container 21 may be performed by the sample dispensing probe 207. The suction of the reagent stored in the storage container 21 may be performed by another dispensing probe.
In the dispensing control processing in the automatic analyzing apparatus 1 according to the above-described first to fourth embodiments, although the dispensing is stopped in step S51 in a case where the state of the sample or the state of the reagent is the predetermined state, the present invention is not limited thereto. That is, in the dispensing control processing, even in a case where the state of the sample or the state of the reagent is the predetermined state, the processing in and after step S53 may be performed by generating additional information for adding information indicating that the state of the sample or the state of the reagent is the predetermined state to the test information and adding the additional information to the test information.
In addition, in the dispensing control processing in the automatic analyzing apparatus 1 according to the above-described first to fourth embodiments, in a case where the observation result information acquired in step S43 includes the liquid level state information, and in a case where there is an air bubble on the liquid level of the sample stored in the storage container 21 or the liquid level of the reagent in the liquid level state information by the control function 91, the automatic analyzing apparatus 1 controls the sample dispensing probe 207 based on the liquid level state information. Specifically, the control function 91 lowers the sample dispensing probe 207 so as to avoid the air bubble on the liquid level of the sample or the liquid level of the reagent based on the liquid level state information. As a result, even in a case where the liquid level is detected by the liquid level detection method using the electrostatic capacitance, the liquid level of the sample or the liquid level of the reagent can be detected without erroneously detecting the air bubble as the liquid level.
Further, although the application of the automatic analyzing apparatus 1 according to the above-described first to fourth embodiments to an automatic analyzing apparatus that performs a biochemical test has been described, the present invention is not limited thereto. That is, the first to fourth embodiments can also be applied to an automatic analyzing apparatus that performs a blood coagulation analysis test.
Note that the word “processor” used in above descriptions means circuits such as, for example, a Central Processing Unit (CPU), a Graphics Processing Unit (GPU), an Application Specific Integrated Circuit (ASIC), a programmable logic device (for example, a Simple Programmable Logic Apparatus (SPLD), a Complex Programmable Logic Apparatus (CPLD), and a Field Programmable Gate Array (FPGA)). The processor executes functions by reading and executing programs stored in the memory 8. Note that programs may be configured to be directly integrated in the processor instead of being storing in the memory 8. In this case, the processor realizes functions by reading and executing programs stored in the circuitry. Note that the processor is not limited to the case arranged as a single processor circuit, but may be configured as a single processor by combining a plurality of independent circuits to realize functions. Furthermore, a plurality of component elements may be integrated into one processor to realize the functions.
While certain embodiments have been described, these embodiments have been presented by way of example only and are not intended to limit the scope of the inventions. The embodiments may be in a variety of other forms. Furthermore, various omissions, substitutions and changes may be made without departing from the spirit of the inventions. The embodiments and their modifications are included in the scope and the subject matter of the invention, and at the same time included in the scope of the claimed inventions and their equivalents.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2022-196479 | Dec 2022 | JP | national |
