Claims
- 1. A method of treating the symptoms of fibromyalgia syndrome or chronic fatigue syndrome, comprising administering to a patient in need of treatment, a therapeutically effective amount of an active agent wherein said active agent is a heterocyclic amine-type compound of formula (A), or a pharmaceutically acceptable salt thereof, wherein:R1, R2, and R3 are independently hydrogen, C1-6 alkyl, C3-5 alkenyl, C3-5 alkynyl, C3-7 cycloalkyl, C4-10 cycloalkyl- or phenyl-substituted C1-6 alkyl; X is hydrogen, C1-6 alkyl, halogen, hydroxy, alkoxy, cyano, carboxamide, carboxyl, or carboalkoxyl; A is CH, CH2, CH-halogen, CHCH3, C═O, C═S, C—SCH3, C═NH, C—NH2, C—NHCH3, C—NHCOOCH3, C—NHCN, SO2, or N; B is CH2, CH, CH-halogen, C═O, N, NH or N—CH3, or O; n is 0 or 1; and D is CH, CH2, CH-halogen, C═O, O, N, NH, or N—CH3.
- 2. The method of claim 1 wherein, in said formula (A), D is N or NH, and n is 0.
- 3. The method of claim 1 wherein, in said formula (A), A is CH, CH2, CHCH3, C═O, C═S, C—SCH3, C═NH, C—NH2, C—NHCH3, C—NHCOOCH3, or C—NHCN.
- 4. The method of claim 1 wherein, in said formula (A), A is CH or C═O.
- 5. The method of claim 1 wherein said compound of formula (A) is a compound of formula (Aa):
- 6. The method of claim 1 wherein said compound of formula (A) is (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]-quinolin-2(1H)-one or (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one.
- 7. The method of claim 1 wherein said compound of formula (A) is a compound of formula (Ab):
- 8. The method of claim 1 wherein said compound of formula (A) is (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]-quinolin-2(1H)one (Z)-2-butenedioate (1:1).
- 9. The method of claim 1 wherein said compound of formula (A) is a compound of formula (Ac), or formula (VIII):
- 10. The method of claim 1 wherein said compound of formula (A) is (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione.
- 11. The method of claim 1 wherein said compound of formula (A) is a compound of formula (Ad), or formula (IX):
- 12. The method of claim 1 wherein said compound of formula (A) is (5R)-5-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline-2(1H)-thione maleate.
- 13. The method of claim 1 wherein, in said formula (A):R1, R2, R3 are independently hydrogen, C1-6 alkyl, C3-5 alkenyl, C3-5 alkynyl, or C3-7 cycloalkyl; X is hydrogen, C1-6 alkyl, halogen, hydroxy, or alkoxy; A is CH, CH2, CH-halogen, CHCH3, C═O, C═S, or C—SCH3; n is 0; and D is CH, CH2, CH-halogen, C═O, O, N, NH, or N—CH3.
- 14. The method of claim 13 wherein, in said formula (A):R1, R2, and R3 are independtly hydrogen, C1-6 alkyl, or C3-5 alkenyl; X is hydrogen, C1-6 alkyl, or halogen; A is CH, CH2, CH-halogen, CHCH3, or C═O; and D is N, NH, or N—CH3.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of the following U.S. provisional applications: Ser. No. 60/198,959 filed Apr. 1, 2000 and Ser. No. 60/200,569 filed Apr. 28, 2000, under 35 U.S.C. §119(e)(1).
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Provisional Applications (2)
|
Number |
Date |
Country |
|
60/198959 |
Apr 2000 |
US |
|
60/200569 |
Apr 2000 |
US |