Claims
- 1. A regime/regimen for treating afflictions/conditions of human skin and/or scalp, comprising administering to a candidate individual in need of such treatment, for such period of time as required to elicit a skin-soothing, -calmant and/or anti-inflammatory response, a thus effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound.
- 2. The regime/regimen as defined by claim 1, comprising topically applying said effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound onto the skin and/or scalp of such candidate individual in need of such treatment.
- 3. The regime/regimen as defined by claim 2, said effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound being formulated into physiologically acceptable vehicle, diluent or carrier therefor.
- 4. A regime/regimen for treating sensitive skin, skin discomfort, tautness, itchiness or swelling of the skin, blotchy red skin, or sensations of burning or warming of the skin, comprising administering to a candidate individual in need of such treatment, for such period of time as required to elicit a skin-soothing, -calmant or anti-inflammatory response, a thus effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound.
- 5. The regime/regimen as defined by claim 1, said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound having the structural formula (I):
- 6. The regime/regimen as defined by claim 5, wherein formula (I), R1 is an alkyl radical having from 6 to 12 carbon atoms.
- 7. The regime/regimen as defined by claim 5, wherein formula (I), R2 is an alkyl radical having from 1 to 12 carbon atoms.
- 8. The regime/regimen as defined by claim 5, said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound having the structural formula (I) being selected from among
2-amino-4-methylaminopyrimidine 3-oxide; 2-amino-4-ethylaminopyrimidine 3-oxide; 2-amino-4-propylaminopyrimidine 3-oxide; 2-amino-4-butylaminopyrimidine 3-oxide; 2-amino-4-pentylaminopyrimidine 3-oxide; 2-amino-4-hexylaminopyrimidine 3-oxide; 2-amino-4-heptylaminopyrimidine 3-oxide; 2-amino-4-octylaminopyrimidine 3-oxide; 2-amino-4-nonylaminopyrimidine 3-oxide; 2-amino-4-decylaminopyrimidine 3-oxide; 2-amino-4-undecylaminopyrimidine 3-oxide; 2-amino-4-dodecylaminopyrimidine 3-oxide; 2-amino-4-tridecylaminopyrimidine 3-oxide; 2-amino-4-tetradecylaminopyrimidine 3-oxide; 2-amino-4-pentadecylaminopyrimidine 3-oxide; 2-amino-4-hexadecylaminopyrimidine 3-oxide; 2-amino-4-heptadecylaminopyrimidine 3-oxide; 2-amino-4-octadecylaminopyrimidine 3-oxide; 2-amino-4-nonadecylaminopyrimidine 3-oxide; 2-amino-4-eicosadecylaminopyrimidine 3-oxide; 2-amino-4-methylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-ethylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-propylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-butylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-pentylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-hexylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-heptylamino-6-methoxypyrimidine 3-oxide; 2-amino-4- octylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-nonylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-decylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-undecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-dodecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-tridecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-tetradecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-pentadecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-hexadecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-heptadecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-octadecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-nonadecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-eicosadecylamino-6-methoxypyrimidine 3-oxide; 2-amino-4-methylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-ethylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-propylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-butylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-pentylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-hexylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-heptylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-octylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-nonylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-decylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-undecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-dodecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-tridecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-tetradecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-pentadecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-hexadecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-heptadecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-octadecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-nonadecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-eicosadecylamino-6-ethoxypyrimidine 3-oxide; 2-amino-4-methylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-ethylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-propylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-butylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-pentylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-hexylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-heptylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-octylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-nonylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-decylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-undecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-dodecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-tridecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-tetradecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-pentadecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-hexadecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-heptadecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-octadecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-nonadecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-eicosadecylamino-6-propyloxypyrimidine 3-oxide; 2-amino-4-methylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-ethylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-propylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-butylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-pentylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-hexylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-heptylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-octylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-nonylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-decylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-undecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-dodecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-tridecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-tetradecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-pentadecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-hexadecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-heptadecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-octadecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-nonadecylamino-6-butyloxypyrimidine 3-oxide; 2-amino-4-eicosadecylamino-6-butyloxypyrimidine 3-oxide; and the branched isomers thereof.
- 9. The regime/regimen as defined by claim 8, said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compoung having the structural formula (I) being selected from among
2-amino-4-hexylaminopyrimidine 3-oxide; 2-amino-4-octylaminopyrimidine 3-oxide; 2-amino-4-dodecylaminopyrimidine 3-oxide; 2-amino-4-octylamino-6-butyloxypyrimidine 3-oxide.
- 10. The regime/regimen as defined by claim 9, said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound having the structural formula (I) being selected from between 2-amino-4-dodecylaminopyrimidine 3-oxide and 2-amino-4-octylamino-6-butyloxypyrimidine 3-oxide.
- 11. The regime/regimen as defined by claim 2, comprising maintaining said effective amount of said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound on the skin and/or scalp of the candidate individual in need of such treatment, for such period of time as required to elicit the desired therapeutic effect, and optionally rinsing same therefrom.
- 12. A cosmetic/dermatological composition suited for soothing or calming a variety of afflictions/conditions of human skin and/or scalp, comprising an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound, formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
- 13. The cosmetic/dermatological composition as defined by claim 12, comprising from 0.01% to 20% by weight of said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound.
- 14. The cosmetic/dermatological composition as defined by claim 12, comprising from 0.05% to 10% by weight of said at least one 2-amino-4-alkylaminopyrimidine 3-oxide compound.
- 15. The cosmetic/dermatological composition as defined by claim 12, formulated as a thickened lotion, gel, emulsion, cream, aerosol, or vapor.
- 16. The cosmetic/dermatological composition as defined by claim 12, further comprising an effective amount of at least one surfactant, thickener, gelling agent, cosmetic agent, preservative, acidifying or basifying agent.
- 17. The cosmetic/dermatological composition as defined by claim 12, further comprising an effective amount of at least one skin-soothing/calmant agent other than a 2-amino-4-alkylaminopyrimidine 3-oxide, keratolytic agent, free-radical scavenger, plant, marine or bacterial extract, phospholipid, linoleic acid, linolenic acid, salicylic acid or derivative thereof, hydroxycarboxylic or ketocarboxylic acid or ester thereof, carotenoid, eicosatetraenoic acid or eicosatrienoic acid or ester or amide thereof, vitamin D or derivative thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
98/14211 |
Nov 1998 |
FR |
|
CROSS-REFERENCE TO PRIORITY APPLICATION
[0001] This application claims priority under 35 U.S.C. §119 of FR-98/14211, filed Nov. 12, 1998, hereby expressly incorporated by reference.