McKenna, James et al., “Bis-steroids as Potential Enzyme Models: Perylene Solubilisation and Dye Spectral Changes with Aqueous Solutions of Some Derivatives of Conessine and Cholic Acid:” J.C.S. Chem. Comm., 1977, pp. 809-811. |
Crum, Rosa et al., “A Class of Steroids Angiogenesis in the Presence of Heparin or a Heparin Fragment,” Science, vol. 230, 1985, pp. 1375-1378. |
Derwent Abstract No. 86-085704, “Anticancer Drug Contains Shark Liver Extract Doxorubicin,” 1984. |
Biosis No. 82085007, “Studies on Antitumor Activity of Squalene and Its Related Compounds,” Yakugaku Zasshi, 1986. |
Chemical Abstract No. 111: 17264, “Increasing the Therapeutic Efficacy of Antitumor Drugs,” 1989. |
Ikekawa, T., et al., Biosis No. 82085007, “Studies on Antitumor Activity of Squalene and Its Related Compounds,” Yakugaku Zasshi (1986). |
Konovalova, V.P., et al., Chemical Abstract No. 111(3):17264, “Increasing the Therapeutic Efficacy of Antitumor Drugs” (1989). |
Bellini, A.M. et al., “Antimicrobial Activity of Basic Cholane Derivatives, Part IX.” Arch. Pharm. (Weinheim) 323,201-205 (1990). |
Bellini, Anna M. et al., Antimicrobial Activity of Basic Cholane Derivatives. Part X. Synthesis of 3α-and 3β-amino-5β-amino-cholan-24-oic Acids, Steroids, vol. 56, Jul. 1991, pp. 395-397. |
Gagliardi, A., et al., “Inhibition of Angiogenesis by Antiestrogens,” Cancer Research, 53, pp. 533-535, Feb. 1, 1993. |
Moore, Karen S. et al., “Squalamine : An Aminosterol Antibiotic from the Shark,” Proc. Natl. Acad. Sci., USA, vol. 90, pp. 1354-1358, Feb. 1993. |
Wehrli, S. et al., “Structure of the Novel Steroidal Antibiotic Squalamine Determined by Two-Dimentional NMR Spectroscopy,” Steroids, vol. 58, No. 8, Aug. 1993, pp. 370-378. |
Zasloff, M., et al., Children's Hospital of Pennsylvania, “Aminosterol Antibiotic.” Current Opinion in Therapeutic Patents Sep. 1993, pp. 1369-1370. |
Moriarty, Robert M. et al. “Synthesis of Squalamine, A Steroidal Antibiotic from the Shark,” Tetrahedron Letters, vol. 35, No. 44, pp. 8103-8106, 1994. |
Sadownik, Andrzej et al. “Rapid Construction of a Squalamine Mimic:” J. A. Chem. Soc., 1995, vol. 117, pp. 6138-6139. |
Marshall, J., “Shark Cartilage for Cancer Treatment,” P&T Newsletter, Mar. 1996, pp. 159-160. |
Bavinaga, M., “Designing Therapies that Target Tumor Blood Vessels:” Science, vol. 275, Jan. 24, 1997, pp. 482-484. |
Akhter, “Squalamine, A Novel Aminosterol Antibiotic is a Specific Inhibitor of Epithelial Brush Border NA+/H+ Exchanger Isoform, NHE3,” FASEB Journal, vol. 10, No. 3 (1996), p. A89. |
Nath, “The Novel Aminoesterol Antibiotics Squalamine and 1436 are Specific Inhibitors of Epithelial Brush Border NA+/H+ Exchanger (NHE) Isoform, NHE3,” Gastroenterology, vol. 110, No. 4, Suppl. (1996), A349. |
Bissery, M., et al., “Preclinical Profile of Docetaxel (Taxotere): Efficacy as a Single Agent and in Combination,” Seminars in Oncology, 22(6):3-16 (1995). |
Kobayashi, E., et al., “Characteristics of Antitumor Activity of KW-2189, a Novel Water-soluble Derivative of Duocarmycin, against Murine and Human Tumors,” Cancer Research 54(9):2404-2410 (1994). |
Kubota, T., et al., Antitumor Effect and Metabolic Activation of Cyclophosphamide and 4-Hydroperoxycyclophosphamide in the Human Breast Carcinoma(MX-1)-Nude Mouse System, GANN: Japanese Journal of Cancer Research 74:437-444 (1983). |
Teicher, B., “Angiogenesis and Cancer Metastases: Therapeutic Approaches,” Critical Reviews in Oncology/Hematology 20:9-39 (1995). |
Tse, M., et al., “The Mammalian Na/HExchanger Gene Family—Initial Structure/Function Studies,” Journal of the American Society of Nephrology, 4(4):969-975 (1993). |
Wiemann, M., et al., “Pharmacology of Antineoplastic Agents,” Medical Oncology: Basic Principles and Clinical Management of Cancer, (New York: MacMillan Publishing Co.), p. 292-362 (1985). |
Boring, C.C. et al., “Cancer Statistics, 1994,” CA: Cancer J. Clin., 44(1):7-26 I(1994). |