Claims
- 1. A pharmaceutical composition useful in treating cholera and related conditions initiated by cholera toxin, which composition comprises:
- a) a monosaccharide or oligosacccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm, wherein said monosaccharide or oligosaccharide sequence binds cholera toxin; and
- b) a pharmaceutically acceptable carrier, wherein said composition is capable of being eliminated from the gastrointestinal tract.
- 2. The composition of claim 1 wherein said monosaccharide or oligosaccharide sequence has from 1 to 10 saccharide units.
- 3. The composition of claim 1 wherein said oligosaccharide sequence is selected from the group consisting of the oligosaccharide structures numbers 6, 8, 9 and 10 set forth in Table 1.
- 4. The composition of claim 1 wherein said oligosaccharide sequence covalently attached to said pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm is selected from the group consisting of the SYNSORBs 41, 72, 75 and 88 set forth in Table 1.
- 5. The composition of claim 1 wherein said linker arm is --(CH.sub.2).sub.8 C(O)--.
Parent Case Info
This application is a continuation, of application Ser. No. 08/460,893, filed Jun. 5, 1995.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5484773 |
Heerze et al. |
Jan 1996 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
460893 |
Jun 1995 |
|