Claims
- 1. A method of maintaining oxygen-delivery capacity of transfusable blood cells comprising admixing said blood prior to transfusion with an effective amount of a compound of the formula ##STR6## wherein R is H, alkyl, aryl or aminoalkyl;
- R.sub.1 is NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 form a cyclic amino group with N to which they are attached;
- R.sub.2 is H, acyl, aminoacyl, alkyl, substituted alkyl wherein the substituents are aryl, cycloalkyl, azacycloalkyl, CONHR, aryloxy or alkoxyalkyl;
- A is H, halo, CF.sub.3, OH, ##STR7## aminoalkyl, aryl, acyl, alkoxy, alkyloxy, or alkoxyalkyloxy; and n is 0-6; wherein said alkyl group in alkyl, aminoalkyl, substituted alkyl, alkoxyalkyl, and alkoxyalkyloxy contains up to 8 carbon atoms and said cycloalkyl group contains 3 to 10 carbon atoms or pharmaceutically acceptable salts thereof.
- 2. The method of claim 1 wherein said kausfusable blood cell cells are human blood cells.
- 3. A method of extending the shelf-life of transfusable red blood cells comprising: admixing said red blood cells with a compound of the formula ##STR8## wherein R is H, alkyl, aryl or aminoalkyl;
- R.sub.1 is NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 form a cyclic amino group with N to which they are attached;
- R.sub.2 is H, acyl, aminoacyl, alkyl, substituted alkyl wherein the substituents are aryl, cycloalkyl, azacycloalkyl, COHNR, aryloxy or alkoxyalkyl;
- A is H, halo, CF.sub.3, OH, ##STR9## aminoalkyl, aryl, acyl, alkoxy, alkyloxy, or alkoxyalkyloxy; and n is 0-6; wherein said alkyl group in alkyl, aminoalkyl, substituted alkyl, alkoxyalkyl, and alkoxyalkyloxy contains up to 8 carbon atoms and said cycloalkyl group contains 3 to 10 carbon atoms or pharmaceutically acceptable salts thereof; and storing the same under physiologically acceptable conditions prior to transfusion.
- 4. The method of claim 3 wherein said compound is ethyl 5-benzyloxy-3-(2-piperidinoethoxy)-2-naphthoate.
- 5. The method of claim 3 wherein said compound is ethyl 5-hydroxy-3-(2-piperidinoethoxy)-2-naphthoate.
- 6. The method of claim 3 wherein said compound is ethyl 5-cyclohexylmethoxy-3-(2-(1-azacycloheptyl)ethoxy-2-naphthoate.
- 7. The method of claim 3 wherein said compound is ethyl 5-(3-phenylpropoxy)-3-(2-piperidinoethoxy)-2-naphthoate.
- 8. The method of claim 3 wherein said compound is 3,5-bis[2(1-pyrrolidinyl)ethoxy]-2-naphthoate.
Parent Case Info
This application is a division of co-pending application Ser. No. 333,520, filed on May 11, 1989, which in turn, is a division of application Ser. No. 211,486 issued as U.S. Pat. No. 4,861,795.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4861795 |
Suh et al. |
Aug 1989 |
|
4948582 |
Suh et al. |
Aug 1990 |
|
Divisions (2)
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Number |
Date |
Country |
Parent |
333520 |
May 1989 |
|
Parent |
211486 |
Jun 1988 |
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