Claims
- 1. A method of treating animals suffering from an appetite disorder comprising administering to said animal an effective amount of a compound of the formula ##STR7## wherein each R' is independently hydrogen or methyl; wherein R is naphthyl or ##STR8## wherein R" and R"' are halo, trifluoromethyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkyloxy or C.sub.3 -C.sub.4 alkenyl; and
- wherein n and m are 0, 1 or 2; and acid addition salts thereof formed with pharmaceutically-acceptable acids.
- 2. A method according to claim 1 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine or a pharmaceutically-acceptable acid addition salt thereof.
- 3. The method of claim 2 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride.
- 4. A method of blocking the uptake of monoamines by brain neurons in animals comprising administering to said animal a monoamine blocking amount of a compound of the formula ##STR9## wherein each R' is independently hydrogen or methyl; wherein R is naphthyl or ##STR10## wherein R" and R"' are halo, trifluoromethyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkyloxy or C.sub.3 -C.sub.4 alkenyl; and
- wherein n and m are 0, 1 or 2; and acid addition salts thereof formed with pharmaceutically-acceptable acids.
- 5. A method according to claim 4 wherein the monoamine to be blocked is serotonin.
- 6. A method according to claim 5 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine or a pharmaceutically-acceptable acid addition salt thereof.
- 7. The method of claim 6 employing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride.
- 8. The method of claim 5 employing N-methyl-3-(o-methylphenoxy)-3-phenylpropylamine or a pharmaceutically-acceptable acid addition salt thereof.
- 9. The method of claim 5 employing N-methyl-3-(o-methylphenoxy)-3-phenylpropylamine hydrochloride.
CROSS-REFERENCE
This is a continuation-in-part of Ser. No. 544,654, filed Oct. 24, 1983, now U.S. Pat. No. 4,584,404, which is a CIP of Ser. No. 872,147 filed Jan. 25, 1978, abandoned, which was a division of Ser. No. 432,379 filed Jan. 10, 1974, now U.S. Pat. No. 4,314,081.
US Referenced Citations (9)
Non-Patent Literature Citations (1)
Entry |
Yoshika et al., "Pharm. Soc. of Japan", vol. 93, pp. 508-528 (1973). |
Divisions (1)
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Number |
Date |
Country |
Parent |
432379 |
Jan 1974 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
872147 |
Jan 1978 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
544654 |
Oct 1983 |
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