Claims
- 1. A method of preventatively treating weight gain which comprises administering to a subject in need of such treatment an effective amount of a steroid selected from the group consisting
- .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol,
- and
- .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one,
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 2. The treatment method of claim 1 wherein the step of treating a subject comprises the step of treating a mammal.
- 3. The treatment method of claim 2 wherein the step of treating a mammal comprises the step of treating a human.
- 4. The treatment method of claim 1 wherein the step of treating a subject with an effective weight gain preventative amount of a steroid comprises the step of treating the subject with about 0.1 to about 2 grams of the steroid per 100 kg body weight per day.
- 5. The treatment method of claim 1 wherein the step of treating a subject with an effective weight gain preventative amount of a steroid comprises the step of treating the subject with about 0.5 to 2 grams of the steroid per 100 kg body weight per day.
- 6. The treatment method of claim 3 wherein the step of treating a human subject with an effective weight gain preventative amount of a steroid comprises the step of treating the human subject with about 0.1 to 2 grams of the steroid per 100 kg body weight per day.
- 7. The treatment method of claim 4 wherein the step of treating the subject with a weight gain preventative steroid comprises the step of administering a therapeutic dose of the steroid to the subject at least once a week.
- 8. The treatment method of claim 4 wherein the step of treating the subject with a weight gain preventative steroid comprises the step of administering a therapeutic dose of the steroid to the subject at least once a day.
- 9. The treatment method of claim 1 wherein the step of treating the subject with a weight gain preventative steroid comprises the step of injecting the subject with the steroid.
- 10. The treatment method of claim 1 wherein the step of treating the subject with a weight gain preventative steroid comprises the step of ingesting the steroid.
- 11. A method of treating excessive body fat which comprises administering to an overweight subject an effective amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol,
- and
- .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one,
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 12. A method of treating obesity which comprises administering to an obese subject a therapeutic amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol,
- and
- .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one,
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 13. A biologically active steroid effective for inhibiting weight gain without inducing a suppression of the appetite or promoting the synthesis of sex hormones comprising .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 14. A biologically active steroid effective for inhibiting weight gain without inducing a suppression of the appetite or promoting the synthesis of sex hormones comprising .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one, and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 15. A method of preventatively treating weight gain which comprises administering to a subject in need of such treatment an effective amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.-ol-7,17-dione
- and
- .DELTA.5-Androstene 3.beta.,7-diol-17-one
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 16. A method of treating excessive body fat which comprises administering to an overweight subject an effective amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.-ol-7,17-dione
- and
- .DELTA.5-Androstene 3.beta.,7-diol-17-one
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
- 17. A method of treating obesity which comprises administering to an obese subject a therapeutic amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.-ol-7,17-dione
- and
- .DELTA.5-Androstene 3.beta.,7-diol-17-one
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid; and (iv) an inorganic acid.
Parent Case Info
This is a continuation of application Ser. No. 07/575,156, filed 29 Aug. 1990 now abandoned.
US Referenced Citations (5)
Continuations (1)
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Number |
Date |
Country |
Parent |
575156 |
Aug 1990 |
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