Trialkylamine derivative and ameliorant for digestive tract movement containing the same

TECHNICAL FIELD
The present invention relates to trialkylamine derivatives useful in the medical field, and more particularly, to trialkylamine derivatives capable of significantly ameliorating the digestive tract movement (gastrointestinal motility), intermediates for preparing the derivatives, and ameliorants for gastrointestinal motility.
BACKGROUND ART
Hitherto, trimebutine maleate has been primarily used as an ameliorant for gastrointestinal motility.
The trimebutine maleate has wide utility due to its two-face activities of promoting and suppressing the gastric movement. However, it is not necessarily satisfactory in that relatively large amounts, i.e., 300 mg per day of dose are required.
To avoid this disadvantage, studies have been conducted in search for ameliorants for gastrointestinal motility which can replace trimebutine maleate.
For example, (1-dimethylaminoindan-1-yl)methyl ester of substituted benzoic acid and (1-dimethylamino-1,2,3,4-tetrahydronaphthalen-1-yl)methyl ester of substituted benzoic acid are reported to have anticonvulsive activity, antiulcer activity and local anesthetic activity ("Scientia Pharmaceutica" vol. 56, pp. 243-250, 1988).
These, however, do not necessarily provide sufficient ameliorating activity on the gastrointestinal motility.
Accordingly, development of drugs which possess more stronger ameliorating activity on the gastrointestinal motility has still been desired.
The present inventors have carried out earnest studies under the mentioned circumstances, and have found that a specified trialkylamine derivatives exhibit excellent ameliorating activity on the gastrointestinal motility leading to completion of the invention.
DISCLOSURE OF THE INVENTION
According to the present invention, there is provided trialkylamine derivatives represented by the formula (1) or pharmaceutically acceptable salts thereof: ##STR2## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents lower alkyl;
R.sup.3, R.sup.4 and R.sup.5 may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen;
R.sup.6 and R.sup.7 may be the same or different from each halogen;
R.sup.6 and R.sup.7 may be the same or different from each other and each represents hydrogen or lower alkyl;
R.sup.8 represents hydrogen, lower alkyl, lower alkoxy or halogen;
X represents oxygen, sulfur, --CH.dbd.N-- or --CH.dbd.CH--;
Y represents oxygen, sulfur, methylene, >N--R.sup.11 (wherein R.sup.11 represents lower alkyl), >SO or >SO.sub.2 ;
Z represents --OCO(CH.sub.2).sub.p .about. or --OCH.sub.2 (CH.sub.2).sub.p .about. (wherein p represents a number of 0 to 4 and symbol .about. represents the linkage with a benzene ring); and
m and n represent each a number of 0 to 3 and the sum of m and n is 3 or less, provided that the case where m is 0, n is 1 or 2, R.sup.1 and R.sup.2 represent each methyl, X represents --CH.dbd.CH--, Y represents --CH.sub.2 --, and Z represents --O--CO.about. is excluded.
The present invention also provides aminoalcohol derivatives represented by the formula (2) or salts thereof: ##STR3## wherein R.sup.1, R.sup.2, R.sup.6, R.sup.7, R.sup.8, X, Y, m and n have the same meaning as defined hereinbefore, provided that the case where X represents --CH.dbd.CH--,
Y represents --CH.sub.2 --,
m is 0 and
n is 1 or 2 is excluded.
The present invention further provides ameliorants for gastrointestinal motility containing, as their active ingredients, trialkylamine derivatives represented by the formula (1): ##STR4## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, X Y, Z, m and n have the same meaning as defined hereinbefore or pharmaceutically acceptable salts thereof.
In the above formulae, the term "lower" means that the number of carbon atoms is 1 to 4, and the term "halogen" means fluorine, chlorine, bromine and iodine.
BEST MODE FOR CARRYING OUT THE INVENTION
The trialkylamine derivatives (1) according to the present invention can be prepared as follows:
First, aminoalcohol derivatives (2), which are the intermediates in the preparation of trialkylamine derivatives (1) of the present invention, are prepared, for example, by the following process. The reaction scheme is shown below: ##STR5## wherein R.sup.9 represents lower alkyl, X, Y, R.sup.1, R.sup.2, R.sup.6, R.sup.7, R.sup.8, m and n have the same meaning as defined hereinbefore.
In detail, the amino acid compound (5) is first esterified to obtain compound (6) by a conventional method, and the amino group of the compound (6) is dialkylated to obtain an ester (7), followed by reducing the ester (7) to produce amino alcohol derivative (2). The reduction is carried out in a solvent and in the presence of a reducing agent at -30.degree. to 80.degree. C. Examples of preferable solvents include ether-series solvents such as diethylether, tetrahydrofuran and dioxane; alcohol-series solvents such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, sec-butanol and tert-butanol, and mixtures of ether-series solvents and alcohol-series solvents. Examples of preferable reducing agents include suitable selections from hydride-series reducing agents such as lithium aluminum hydride, sodium borohydride, lithium triethylborohydride, aluminum diisobutyl hydride, lithium borohydride and diborane.
Among the aminoalcohol derivatives (2), compounds containing a sulfur atom as Y can be coverted to sulfoxides or sulfones by oxidizing the compounds in accordance with a conventional method.
It is preferred that the oxidizing agents be metachloro perbenzoic acid, hydrogen peroxide, sodium periodate, peroxosulfates and the like.
Among the trialkylamine derivatives (1) of the present invention, those containing a group --O--CO.about. (.about. has the same meaning as defined above) as Z can be prepared by reacting the aminoalcohol derivatives (2), which are the intermediates of the process, with carboxylic acid compounds represented by the formula (3): ##STR6## wherein R.sup.3, R.sup.4, and R.sup.5 have the same meaning as defined above or their reactive derivatives such as acid halogenides, acid anhydrides, mixed acid anhydrides and active esters.
When the reactive derivatives of carboxylic acids (3) are employed, the reaction is performed in a solvent and in the presence or absence of a basic compound at -30.degree. to 100.degree. C.
No particular limitation is imposed on the solvents as long as they do not adversely affect the reaction. Examples of preferable solvents include ether-series solvents such as diethylether, tetrahydrofuran and dioxane; halogenated hydrocarbon-series solvents such as dichloromethane, dichloroethane, chloroform and carbon tetrachloride; aromatic hydrocarbon-series solvents such as benzene, toluene and xylene; acetonitrile, dimethylformamide, dimethylsulfoxide and water. Examples of preferable basic compounds include trialkylamine, pyridine, alkali metal carbonate, alkali metal hydrogen-carbonate and alkali metal hydroxide.
When the carboxylic acid compounds (3) are used in the form of free caroxylic acids, it is preferred to use a condensing agent. Examples of preferable condensing agents include carbodiimides such as N, N'-dicyclohexylcarbodiimide, N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide and its hydrochloride and carbonyldiimidazole.
Among the compounds (1) of the present invention, those containing --O--CH.sub.2 .about. (wherein .about. has the same meaning as defined above) as Z can be prepared by reacting aminoalcohol derivatives (2) with benzyl compounds represented by the formula (4): ##STR7## wherein W represents a reactive residue and R.sup.3, R.sup.4 and R.sup.5 have the same meaning, respectively.
Examples of the reactive residue represented by W in the benzyl compounds (4) include halogen, methanesulfonyloxy, alkylsulfonyloxy, p-toluenesulfonyloxy and arylsulfonyloxy.
The above reaction is carried out in a solvent and in the presence or absence of a basic compound at 0.degree. to 100.degree. C. No particular limitation is imposed on the solvents useful in the present invention as long as they do not adversely affect the reaction. Examples of preferable solvents include ether-series solvents such as diethylether, tetrahydrofuran and dioxane; aromatic hydrocarbon-series solvents such as benzene, toluene and xylene; dimethylformamide and dimethylsulfoxide. Examples of preferable basic compounds include alkali metal hydride, alkali metal alkoxide and alkali metal hydroxide.
Compounds having a sulfur atom as Y in the compounds (1) of the present invention can be oxidized to sulfoxides or sulfones by conventional methods.
Preferable examples of the oxidizing agents include metachloroperbenzoic acid, hydrogen peroxide, sodium periodate and peroxosulfates.
Examples of the pharmaceutically acceptable salts of the compounds (1) of the present invention include inorganic acid salts such as hydrochlorides, hydrobromides, sulfates and phosphates and organic acid salts such as succinates, maleates, fumarates, tartrates, oxalates, methanesulfonates and paratoluenesulfonates.
Since the compounds (1) according to the present invention possess asymmetric carbon atoms, the compounds may have optical isomers or stereochemical isomers. The present invention encompasses these isomers, too.
The compounds (1) according to the present invention or their pharmaceutically acceptable salts have an action of ameliorating gastrointestinal motility.
In order to formulate ameliorants for gastrointestinal motility from the compounds (1) of the present invention or their pharmaceutically acceptable salts, the compounds are blended with pharmaceutically acceptable adjuvants and prepared to take suitable forms for oral-route administration or non-oral route administration.
In the manufacture of oral-route preparations, the mentioned compounds are blended with suitable additives, for example, vehicles such as lactose, mannitol, corn starch and crystalline cellulose; binders such as cellulose derivatives, gum arabic and gelatin; disintegrators such as carboxymethylcellulose calcium and lubricants such as magnesium stearate, and formed into tablets, powders, granules, capsules and the like. These solid preparations may further be coated with coating bases such as hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, cellulose acetate phthlate and methacrylate copolymers and formed into enteric preparations.
In the manufacture of non-oral route preparations, the compounds of the invention may be combined, for example, with water, ethanol, glycerol or surfactants which are routinely used in the pharmaceutical field and prepared into injection preparations; or combined with suppository bases to form suppositories.
The amounts of administration of the compounds (1) of the present invention vary depending on the age, body weight, state of the disease, aimed effects of the treatment, manner of administration, period of administration, etc. Generally, the compounds are administered in amounts of 1-2000 mg/day, preferably 10-300 mg/day, which are given as divided in 1 to 3 times a day in the case of oral-route administration.

EXAMPLES
The present invention will hereinafter be described in more detail by way of examples, which however should not be construed as limiting the invention thereto.
EXAMPLES 1-21
Preparation examples of aminoalcohol derivative (2), a preparatory intermediate of the present invention, are shown below.
EXAMPLE 1
Preparation of 4-dimethylamino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzothiophene
The title compound was obtained via the following Steps 1-3.
Step 1: Preparation of 4-amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene
22.62 g of 4,5,6,7-tetrahydro-spiro[1-benzothiophen-4,4'-imidazolidine]-2',5'-dione was added to 300 ml of 20% NaOH solution and refluxed for 20 hours under heat. After cooling, the system was made weakly acidic with HCl, then neutralized with an ammonia solution. After filtration, the filtrate was condensed and dried, and the residue was added with 200 ml of methanol and 15 ml of conc. H.sub.2 SO.sub.4, followed by reflux under heat for 20 hours. After cooling, the solvent was removed under reduced pressure, and to the residue was added water, and then sodium hydrogencarbonate for making the system basic, followed by extracting with chloroform. After the chloroform phase was dried, the solvent was removed to obtain 15.15 g of the title compound as a pale yellow oily product.
The IR and MS data are shown below.
IR(neat)cm.sup.-1 : 1720
MS(m/z): 211(M.sup.+)
The chemical formula is shown below. ##STR8##
Step 2: Preparation of 4-dimethylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene
25 ml of formic acid containing 9.96 g of 4-amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene obtained in Step 1 above was added with 9 ml of 35% formalin solution and heated at 100.degree. C. for 30 minutes. After cooling, the reaction mixture was poured into ice-water, neutralized with sodium hydrogencarbonate and extracted with ether. The ether phase was washed with water and dried. The solvent was removed to obtain 7.80 g of the title compound as pale yellow crystals.
The melting point and MS are shown below.
Melting point: 72.degree.-73.degree. C.
MS(m/z): 239(M.sup.+)
The chemical formula is shown below. ##STR9##
Step 3: Preparation of 4-dimethylamino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzothiophene
65 ml of ether solution containing 7.77 g of 4-dimethylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene obtained in Step 2 was added to an ice-cooled suspension of aluminum lithium hydride (1.23 g) in ether, then stirred for 20 minutes at room temperature. The reaction mixture was added with 5% NaOH solution, filtrated to remove the insoluble matters, followed by drying the organic phase.
The solvent was distilled off to obtain 6.58 g of the title compound as colorless crystals.
The melting point, IR, MS and NMR data are shown below.
Melting point: 71.degree.-72.degree. C.
IR(KBr)cm.sup.-1 : 3130
MS(m/z): 211(M.sup.+)
NMR(CDCl.sub.3).delta.: 1.47-1.58(1H,m), 1.71-1.98(3H,m), 2.21(6H,s), 2.74(2H,t), 3.53(1H,d), 3.70(1H,d), 7.04(1H,d), 7.11(1H,d)
The chemical formula is shown below. ##STR10##
EXAMPLE 2
Preparation of 4-dimethylamino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzofuran
The title compound was obtained via the following Steps 1-3.
Step 1: Preparation of 4-amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzofuran
The title compound was obtained by following the procedure of Step 1 in Example 1 except that 4,5,6,7-tetrahydro-spiro[1-benzofuran-4,4'-imidazolidine]-2',5'-dione was used as the starting material.
Step 2: Preparation of 4'-dimethylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzofuran
0.9 ml of 35% formalin solution was added to 10 ml of methanol containing 1.00 g of 4-amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzofuran obtained in Step 1 above. Subsequently, 10% palladium on carbon moistened with water was added to this solution. The reaction was continued for 3 hours in a hydrogen atmosphere, and then the insoluble matters were separated by filtration through celite. The filtrate was dried over anhydrous magnesium sulfate, and the solvent was removed to obtain 1.07 g of the title compound as a pale yellow oily product.
The IR data are shown below.
IR (neat ) cm.sup.-1 : 1730
The chemical formula is shown below. ##STR11##
Step 3: Preparation of 4-dimethylamino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzofuran
The title compound was obtained by following the procedure of Step 3 in Example 1 except that 4-dimethylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzofuran obtained in Step 2 was used as the starting material.
The melting point, IR, MS and NMR data are shown below.
Melting point: 91.degree.-92.degree. C.
IR (KBr) cm.sup.-1 : 3200
MS (m/z): (CI) 196 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.38.about.1.50 (1H, m), 1.68.about.2.00 (3H, m), 2.24(6H, s), 2.57 (2H, t), 3.10.about.3.40 (1H, brs), 3.47 (1H, d), 3.67 (1H, d), 6.43 (1H, d), 7.25 (1H, d)
The chemical formula is shown below. ##STR12##
EXAMPLE 3
Preparation of 4-(N-ethyl-N-methyl)amino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzothiophene
The title compound was obtained by following the Steps 1-3 below.
Step 1: Preparation of 4-N-acetylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene
10.0 g of 4-amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene and 5.27 g of triethylamine were dissolved in methylene chloride. 5.32 g of acetic anhydride was added thereto under ice-cooling, then the temperature was returned to room temperature and the mixture was stirred for 30 minutes.
After completion of the reaction, the reaction solution was diluted with ethyl acetate, then washed with 1N HCl and saturated aqueous sodium bicarbonate solution, and dried over anhydrous magnesium sulfate. Subsequently, the solvent was distilled off under reduced pressure to obtain 10.9 g of the title compound as pale brown crystals.
The IR data are shown below.
IR(KBr)cm.sup.-1 : 3265, 1735, 1640
The chemical formula is shown below. ##STR13##
Step 2: Preparation of 4-(N-acetyl-N-methyl)amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene
To 120 ml of tetrahydrofuran suspended with 4.22 g of 60% sodium hydride was added, under ice-cooling, 120 ml of tetrahydrofuran containing 17.70 g of 4-N-acetylamino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene as dissolved therein, followed by raising the temperature to room temperature while stirring for 20 minutes. Subsequently, 20 ml of anhydrous tetrahydrofuran containing 8.9 ml of methyl iodide as dissolved was added thereto dropwise, followed by stirring for 3 hours at 50.degree. C.
After completion of the reaction, the reaction solution was condensed under reduced pressure, then poured into ice-water, and extracted with ethyl acetate. The ethyl acetate phase was washed with brine and dried over anhydrous magnesium sulfate, and then distilled off under reduced pressure to obtain 20.98 g of the title compound as a yellow oily product.
The MS data are shown below.
Ms(m/z): 267(M.sup.+)
The chemical formula is shown below. ##STR14##
Step 3: Preparation of 4-(N-ethyl-N-methyl)amino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzothiophene
The title compound (oily product) was obtained by following the procedure of Step 3 in Example 1 except that 4-(N-acetyl-N-methyl)amino-4-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophene obtained in Step 2 was used as the starting material.
The IR, MS and NMR data are shown below.
IR(neat)cm.sup.-1 : 3440, 2935-2800
MS (m/z):(CI)226 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.03 (3H, t), 1.49.about.1.59 (1H, m), 1.68.about.1.96 (3H, m), 2.20 (3H, s), 2.23.about.2.44 (2H, m), 2.74 (2H, t), 3.49 (1H, brs), 3.49 (1H, d), 3.68 (1H, d), 7.03 (1H, d), 7.10 (1H, d) ##STR15##
EXAMPLE 4
Preparation of 4-dimethylamino-1-methyl-4-hydroxymethyl-1,2,3,4-tetrahydroquinoline
The title compound was obtained via the following Steps 1-3.
Step 1: Preparation of 4-amino-4-methoxycarbonyl-1-methyl-1,2,3,4-tetrahydroquinoline
The title compound was obtained by following the procedure of Step 1 in Example 1 except that 1',2',3',4'-tetrahydro-1'-methyl-spiro[imidazolidine-4,4'-quinoline]-2,5-dione was used as the starting material.
Step 2: Preparation of 4-dimethylamino-4-methoxycarbonyl-1-methyl-1,2,3,4-tetrahydroquinoline
1.55 g of 4-amino-4-methoxycarbonyl-1-methyl-1,2,3,4-tetrahydroquinoline obtained in Step 1 was dissolved in 50 ml of dimethylformamide, then added with 2.24 g of methyl iodide and 2.14 g of anhydrous potassium carbonate and the mixture was stirred at room temperature for 15 hours. The reaction mixture was poured into water and extracted with ether. The ether phase was washed with water and dried with anhydrous magnesium sulfate. The solvent was removed to obtain 1.51 g of the title compound as pale yellow crystals.
The melting point, IR and MS data are shown below.
Melting point: 45.degree.-46.degree. C.
IR (KBr)cm.sup.-1 : 1720, 1240, 755
MS (m/z): 248 (M.sup.+)
The chemical formula is shown below. ##STR16##
Step 3: Preparation of 4-dimethylamino-4-hydroxymethyl-1,2,3,4-tetrahydroquinoline
The title compound was obtained by following the procedure of Step 3 in Example 1 except that 4-dimethylamino-4-methoxycarbonyl-1-methyl-1,2,3,4-tetrahydroquinoline obtained in Step 2 was used as the starting material.
The melting point, IR, MS and NMR data are shown below.
Melting point: 104.degree.-105.degree. C.
IR(KBr)cm.sup.-1 : 1500, 1105, 760
MS (m/z):(FAB)221 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.71.about.1.79(1H, m), 2.11.about.2.22(1H, m), 2.25(3H, s), 2.27(3H, s), 2.55 (1H, bs), 2.88 (3H, s), 3.12.about.3.28 (2H, m), 3.64(1H, d), 3.74(1H, d), 6.59.about.6.70(2H, m), 7.12.about.7.18 (1H, m), 7.57 (1H, dd)
The chemical formula is shown below. ##STR17##
EXAMPLE 5
Preparation of 4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzopyran.HCl
The title compound was obtained by following the procedures of Steps 1-3 in Example 1 except that 2,3-dihydro-spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione was used as the starting material, and then converted to a hydrochloride.
The melting point, IR, MS and NMR data are shown below.
Melting point: 216.degree.-217.degree. C.
IR(KBr)cm.sup.-1 : 1060
MS (m/z): 207 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.05.about.2.30 (1H, m), 2.40.about.2.60 (4H, m), 3.08 (3H, d), 4.08.about.4.17 (2H, m), 4.30.about.4.40 (1H, m), 4.55.about.4.70 (1H, m), 6.85.about.6.94 (1H, m), 7.03.about.7.15 (1H, m), 7.23.about.7.35 (1H, m), 7.95.about.8.05 (1H, m) ##STR18##
EXAMPLE 6
Preparation of 4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzothiopyran
The title compound was obtained by following the procedures of Steps 1-3 in Example 1 except that 2,3-dihydro-spiro[4H-1-benzothiopyran-4,4'-imidazolidine]-2',5'-dione was used as the starting material.
The melting point, IR, MS and NMR data are shown below.
The melting point: 94.degree.-95.degree. C.
IR (KBr)cm.sup.-1 : 2700.about.3050
MS (m/z): 223 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.06.about.2.23(3H, m),2.28(6H, s),2.87.about.2.96(1H, m), 3.07.about.3.17 (1H, m), 3.71 (2H, dd), 7.03.about.7.15 (3H, m), 7.71.about.7.74(1H, m)
The chemical formula is shown below. ##STR19##
EXAMPLE 7
Preparation of 5-dimethylamino-5-hydroxymethylcyclopenta[b]thiophene
The title compound was obtained by following the procedures of Steps 1-3 in Example 1 except that spiro[cyclopenta[b]thiophene-5,4'-imidazolidine]-2',5'-dione was used as the starting material.
The IR, MS and NMR data are shown below.
IR(neat)cm.sup.-1 : 2780-3070
MS (m/z): 196 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.27 (6H, s), 2.55.about.2.74 (2H, m), 2.95(1H, d), 3.09(1H, d), 3.65 (2H, s), 6.76 (1H, d), 7.14.about.7.15 (1H, m),
The chemical formula is shown below. ##STR20##
EXAMPLES 8-19
Compounds of the following nomenclature, chemical formulae, melting points, IR, MS and NMR data were obtained by following the procedure of Example 1.
EXAMPLE 8
4-Dimethylamino-4-hydroxymethyl-cyclopenta[b]thiophene ##STR21## Melting point: 48.degree.-49.degree. C. IR (KBr) cm.sup.-1 : 3175, 1465, 1040
MS (m/z):(FAB) 198(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 2.01.about.2.11(1H, m), 2.18(6H, s), 2.57.about.2.67(1H, m), 2.87.about.2.92 (2H, m), 3.00 (1H, brs), 3.57 (1H, d), 3.74(1H, d)
EXAMPLE 9
4-Dimethylamino-4-hydroxymethyl-cyclohepta[b]thiophene.HCl ##STR22## Melting point: 165.degree. C. IR(KBr) cm.sup.-1 : 3200
MS (m/z):(CI)226(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.42.about.1.96(4H, m),2.14.about.2.25(2H, m), 2.56(3H, d), 2.77.about.2.89 (1H, m), 3.10.about.3.22 (1H, m), 3.74(1H, dd), 4.10 (1H, dd), 5.95.about.6.05 (1H, m), 7.33 (1H, d), 7.44 (1H, d) 9.76.about.9.86 (1H, brs)
EXAMPLE 10
5-Dimethylamino-5-hydroxymethyl-5,6,7,8-tetrahydroquinoline ##STR23## Melting point: 125.degree.-126.degree. C. IR(KBr) cm.sup.-1 : 3130
MS (m/z): (CI) 207 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.61.about.2.03(4H, m), 2.22(6H, s), 2.75.about.2.79(3H, m), 3.54 (1H, d), 3.76 (1H, d), 7.12 (1H, dd), 7.96 (1H, dd), 8.40 (1H, dd)
EXAMPLE 11
1-Dimethylamino-1-hydroxymethyl-cycloheptabenzene ##STR24##
Oily product
IR(neat)cm.sup.-1 : 3450, 2935-2785
MS (m/z):(CI)220(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.34.about.1.45(1H, m), 1.52.about.1.80(4H, m), 1.85.about.2.04 (2H, m), 2.25 (6H, s), 2.82.about.2.86 (2H, m), 3.74(1H, d), 3.81 (1H, d), 7.08(1H, d), 7.15(1H, dt), 7.21 (1H, dt), 7.76 (1H, d)
EXAMPLE 12
6-Chloro-4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzopyran ##STR25## Melting point: 107.degree.-108.degree. C. IR (KBr)cm.sup.-1 : 3400, 1485, 1070
MS (m/z):(FAB)242 (M.sup.+ 30 1)
NMR (CDCl.sub.3) .delta.: 1.71 (1H, m), 2.21 (1H, m), 2.23 (6H, s), 2.81 (1H, brs), 3.67 (1H, d), 3.78 (1H, d), 4.17 (2H, m), 6.76 (1H, d), 7.09 (1H, dd), 7.54 (1H, d)
EXAMPLE 13
4-Dimethylamino-6-fluoro-4-hydroxymethyl-2,3-dihydro-4H-1-benzopyran ##STR26## Melting point: 100.degree.-103.degree. C. IR (KBr) cm.sup.-1 : 3050.about.2800, 1490, 1460
MS (m/z):(CI)226(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.69 (1H, ddd), 2.16.about.2.28 (1H, m), 2.23 (6H, s), 2.60 (1H, brs), 3.68 (1H, d), 3.78 (1H, d), 4.06.about.4.23 (2H, m), 6.77 (1H, dd), 6.86 (1H, ddd), 7.29 (1H, dd)
EXAMPLE 14
4-Dimethylamino-4-hydroxymethyl-6-methoxy-2,3-dihydro-4H-1-benzopyran ##STR27## Melting point: 90.degree.-91.degree. C. IR(KBr)cm.sup.-1 : 3075.about.2775, 1580, 1500
MS (m/z): (CI) 238 (M.sup.+ +1),
NMR (CDCl.sub.3) .delta.: 1.70(1H, ddd), 2.17.about.2.28 (1H, m), 2.24(6H, s), 2.55 (1H, brs), 3.64.about.3.81 (2H, m), 3.76 (3H, s), 4.06.about.4.20 (2H, m), 6.71.about.6.79 (2H, m), 7.12 (1H, dd)
EXAMPLE 15
4-Dimethylamino-4-hydroxymethyl-6-methyl-2,3-dihydro-4H-1-benzopyran.HCl ##STR28## Melting point: 110.degree.-111.degree. C. IR(KBr) cm.sup.-1 : 3300, 1500, 1230
MS (m/z): (FAB) 222 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.71(1H, m), 2.22(1H, m), 2.23(6H, s), 2.27(3H, s) 2.59 (1H, brs), 3.70 (1H, d), 3.79 (1H, d), 4.14 (2H, m), 6.72 (1H, d), 6.95 (1H, dd), 7.34 (1H, d)
EXAMPLE 16
4-Dimethylamino-4-hydroxymethyl-2,2-dimethyl-2,3-dihydro-4H-1-benzopyran ##STR29## Melting point: 84.degree.-85.degree. C. IR(KBr)cm.sup.-1 : 3120
MS (m/z) : (CI) 236 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.27(3H, s), 1.39 (3H, s), 1.58(1H, d), 2.10(1H, d), 2.15(6H, s), 3.26.about.3.46 (1H, brs), 3.76 (2H, s), 6.81 (1H, dd), 6.92 (1H, ddd), 7.15 (1H, ddd), 7.59 (1H, dd)
EXAMPLE 17
6-Chloro-4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H- 1-benzothiopyran ##STR30## Melting point: 88.degree.-89.degree. C. IR (KBr)cm.sup.-1 : 3200, 1470, 1080
MS (m/z): (FAB) 258 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.:2.12(2H, m), 2.26(6H, s), 2.29(1H, brs),2.89(1H, m), 3.10(1H, m), 3.63 (1H, d), 3.71 (1H, d), 7.05 (2H, m), 7.74 (1H, m)
EXAMPLE 18
4-Dimethylamino-4-hydroxymethyl-6-methoxy-2,3-dihydro-4H-1-benzothiopyran ##STR31## Melting point: 116.degree.-117.degree. C. IR (KBr)cm.sup.-1 : 3450, 1470, 1290
MS (m/z): (FAB) 254 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 2.06 (1H, m), 2.19 (1H, m), 2.26 (6H, s), 2.36 (1H, brs), 2.85 (1H, m), 3.08 (1H, m), 3.64 (1H, d), 3.70 (1H, d), 3.76 (3H, s), 6.71 (1H, dd), 7.03 (1H, d), 7.36 (1H, d)
EXAMPLE 19
4-Dimethylamino-4-hydroxymethyl-6-methyl-2,3-dihydro-4H-1-benzothiopyran ##STR32## Melting point: 84.degree.-85.degree. C. IR (KBr)cm.sup.-1 : 3200, 1480, 1080
MS (m/z): (FAB) 238 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 2.08 (1H, m), 2.20 (1H, m), 2.27 (6H, s), 2.29 (3H, s), 2.88 (1H, m), 3.10 (1H, m), 3.66 (1H, d), 3.73 (1H, d), 6.92 (1H, dd), 7.02 (1H, dd), 7.55 (1H, d)
EXAMPLE 20
Preparation of 4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzothiopyran-1-oxide
The title compound was obtained via the following procedure.
248 mg of 70% m-chloroperbenzoic acid was added to a 20 ml of methylene chloride solution containing 222 mg of 4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzothiopyran dissolved therein, and stirred at room temperature for 30 minutes. The reaction solution was washed with 5% aqueous sodium thiosulfate solution, saturated sodium bicarbonate solution and brine in this order, then dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the crystals were recrystallized from a solvent mixture of ethyl acetate and isopropyl ether. 53 mg of the title compound was obtained as colorless crystals. ##STR33## Melting point: 132.degree.-133.degree. C. IR(KBr)cm.sup.-1 : 3245, 1070, 1000
MS (m/z): (CI) 240 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.88(1H, m), 2.26(6H, s), 2.40(1H, dd), 2.85(1H, m), 3.01 (1H, m), 3.24 (1H, m), 3.59 (1H, d), 3.73 (1H, d), 7.43 (1H, dt), 7.53 (1H, dt), 7.75 (1H, dd), 7.90 (1H, dd)
EXAMPLE 21
Preparation of 4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzothiopyran-1,1-dioxide
The title compound was obtained via the following procedure.
10 g of 4-dimethylamino-4-hydroxymethyl-2,3-dihydro-4H-1-benzothiopyran obtained in Example 6 were suspended in 100 ml of water, to which 50 ml of an aqueous solution of 20 g of potassium peroxomonosulfate was added while stirring under ice cooling. After allowing to react for 1 hour, 3N NaOH solution was added thereto for neutralizing the mixture, followed by extraction with ether. After the ether phase was dried with anhydrous magnesium sulfate, the solvent was condensed to obtain 5.73 g of the title compound as colorless crystals. ##STR34## Melting point: 137.degree.-138.degree. C. IR(KBr) cm.sup.-1 : 1290, 1130, 760
MS (m/z): 255 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.00(1H, brs), 2.25(6H, s), 2.38(1H, ddd), 2.80 (1H, ddd), 3.33 (1H, ddd), 3.62 (1H, ddd), 3.82 (2H, s), 7.40.about.7.65 (2H, m), 7.85 (1H, dd), 7.96 (1H, dd)
EXAMPLES 22-86
Preparation examples of trialkylamine derivative (1) of the present invention are shown below.
EXAMPLE 22
Preparation of 4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-4,5,6,7-tetrahydro-1-benzothiophene
15 ml of pyridine Containing 1.52 g of 4-dimethylamino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzothiophene obtained in Example 1 was cooled with ice, and added with 1.82 g of 3,4,5-trimethoxybenzoylchloride. The reaction mixture was then stirred at room temperature for 14 hours. The solvent was removed under reduced pressure, and the residue was poured into water, followed by extracting with chloroform. The chloroform phase was washed with water and dried. The solvent was removed under reduced pressure, and the residue was crystallized from isopropyl ether to obtain 1.87 g of the title compound as colorless crystals.
The melting point, IR, MS and NMR data are shown below.
Melting point: 82.degree.-83.degree. C.
IR(KBr)cm.sup.-1 : 1710
MS(m/z): 405(M.sup.+)
NMR (CDCl.sub.3) .delta.: 1.68.about.1.80(1H, m), 1.90.about.2.10 (3H, m), 2.27(6H, s), 2.77 (2H, t), 3.87 (6H, s), 3.89 (3H, s), 4.41 (1H, d), 4.59 (1H, d), 7.04 (1H, d), 7.14 (1H, d), 7.18 (2H, s)
Hydrochloride of the present product: colorless crystals
Melting point: 201.degree.-202.degree. C. (solvent for recrystalization: chloroform - isopropyl ether ) ##STR35##
EXAMPLES 23-28
Six kinds of compounds were obtained by following the procedure of Example 22. The chemical formulae, melting points, IR, MS and NMR data of these compounds are shown in Table 1.
TABLE 1-1__________________________________________________________________________ ##STR36##Ex. Melting MS IRNo. Q m n R.sup.3 R.sup.4 R.sup.5 point .degree.C. (m/z) (cm.sup.-1) NMR__________________________________________________________________________23 -- 1 0 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 138.about.140 (Cl) (KBr) (CDCl.sub.3) .delta.: 2.43(6H, s), 2.84.about.2.89(1H, m), 392 2750.about.3100 3.02(2H, d), 3.17(1H, d), 3.82(6H, s), (M.sup.+ + 1) 1695 3.88(3H, s), 4.47(2H, s), 6.78(1H, d) 7.13.about. 7.15(3H, m)24 HCl 0 2 4-OCH.sub.3 H H 194.about.195 (Cl) (KBr) (CDCl.sub.3) .delta.: 1.93.about.2.12(3H, m), 346 2850.about.3125 2.29.about.2.33(1H, m), 2.64(3H, d), (M.sup.+ + 1) 1710, 1605 2.80.about.2.91(2H, m), 3.00(3H, d), 3.87(3H, s), 4.89(1H, d), 4.96(1H, d), 6.94.about.6.98(2H, m), 7.25(1H, d), 7.87(1H, d), 8.11.about.8.14(2H,__________________________________________________________________________ m)
TABLE 1-2__________________________________________________________________________ Melting MS IREx. No. Q m n R.sup.3 R.sup.4 R.sup.5 point .degree.C. (m/z) (cm.sup.-1) NMR__________________________________________________________________________25 HCl 0 2 4-CO H H 187.about.191 (C1) (KBr) (CDCl.sub.3) .delta.: 1.80.about.2.36(4H, m), 2.65(3H, d,) OCH.sub.3 373 2400.about.3100 2.70.about.3.03(5H, m), 3.95(3H, s), (M.sup.+ + 1) 1720 4.94(1H, d), 5.05(1H, d), 7.27(1H, d), 7.88.about.7.90(1H, m), 8.12.about.8.24(4H, m)26 HCl 0 2 H H H 207 (Cl) (KBr) (CDCl.sub.3) .delta.: 1.87.about.2.20(3H, m), 316 1715 2.28.about.2.38(1H, m), 2.64(3H, d), (M.sup.+ + 1) 2.73.about.3.07(5H, m), 7.24.about.7.28(1H, m), 7.43.about.7.53(2H, m), 7.58.about. 7.65(1H, m), 7.90.about.7.94(1H, m), 8.10.about.8.16(2H, m)27 HCl 0 2 4-Cl H H 188.about.189 (Cl) (Kbr) (CDCl.sub.3) .delta.: 1.87.about.2.36(4H, m), 2.65(3H, m), 350 1720 2.69.about.2.94(2H, m), 2.98(3H, d), (M.sup.+ + 1) 4.88(1H, d), 4.99(1H, d), 7.25(1H, d), 7.43.about.7.50(2H, m), 7.89(1H, dd), 8.11.about.8.18(2H, m), 12.64.about.12.87(1H, brs)28 HCl 0 2 3-OCH.sub.3 4-OCH.sub.3 H 202.about.203 (Cl) (KBr) (CDCl.sub.3) .delta.: 1.90.about.2.35(4H, m), 2.66(3H, d), 376 1720 2.70.about.2.91(2H, m), 2.98(3H, d), (M.sup.+ + 1) 3.96(6H, d), 4.87(1H, d), 4.95(1H, d), 6.95(1H, m), 7.22.about.7.28(1H, m), 7.58.about.7.62(1H, m), 7.83.about.7.95(2H,__________________________________________________________________________ m)
EXAMPLES 29-34
Six kinds of compounds were obtained by following the procedure of Example 22. The chemical formulae, melting points, IR, MS and NMR data of these compounds are shown in Table 2.
TABLE 2-1__________________________________________________________________________ ##STR37##Ex. Melting MS IRNo. Q Y m n R.sup.3 R.sup.4 R.sup.5 point .degree.C. (m/z) (cm.sup.-1) NMR__________________________________________________________________________29 HCl 0 0 2 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 217.about.219 401 (KBr) (CDCl.sub.3) .delta.: 2.35.about.2.65(5H, m), (M.sup.+) 1710, 1120 2.92.about.2.98(3H, m), 3.74(3H, s), 3.85(6H, s), 4.00.about.4.50(2H, m), 4.94(2H, dd), 6.96(1H, d), 7.00.about. 7.10(1H, m), 7.26(2H, s), 7.30.about. 7.40(1H, m), 8.00.about.8.10(1H, m)30 HCl S 0 2 3-OCH.sub.3 4-OCH.sub. 3 5-OCH.sub.3 185.about.186 417 (KBr) (CDCl.sub.3) .delta.: 2.43.about.2.53(1H, m) (M.sup.+) 2850.about.3010 2.66(3H, d), 2.73.about.2.79(1H, m), 1710, 1585 2.83.about.2.97(1H, m), 3.04(3H, d), 3.23.about.3.32(1H, m), 3.91(3H, s), 3.92(6H, s), 5.08(2H, dd), 7.24.about.7.35(5H, m), 7.43(1H, d)__________________________________________________________________________
TABLE 2-2__________________________________________________________________________ Melting MS IREx. No. Q Y m n R.sup.3 R.sup.4 R.sup.5 point .degree.C. (m/z) (cm.sup.-1) NMR__________________________________________________________________________31 -- CH.sub.2 1 0 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 105.about.106 (Cl) (KBr) (CDCl.sub.3) .delta.: 2.51(6H, s), 386 1700 3.10(2H, d), 3.20(2H, d), (M.sup.+ + 1) 3.83(3H, s), 3.89(3H, s), 4.41(2H, s), 7.07.about.7.21(4H, m)32 -- CH.sub.2 1 0 4-OCH.sub.3 H H 85.about.86 (Cl) (KBr) (CDCl.sub.3) .delta.: 2.49(6H, s), 326 1700 3.09(2H, d), 3.18(2H, d), 3.85(3H, s), (M.sup.+ + 1) 4.38(2H, s), 6.82.about.6.90(2H, m), 7.08.about.7.20(2H, m), 7.25.about.7.83(2H, m)33 -- CH.sub.2 1 0 4-Cl H H 119.about.120 (Cl) (KBr) (CDCl.sub.3) .delta.: 2.48(6H, s), 3.08(2H, d), 330 2760.about.3100 3.20(2H, d), 4.41(2H, s), (M.sup.+ + 1) 1705,1100 7.07.about.7.19(4H, m), 7.32.about.7.36(2H, m), 7.69.about.7.73(2H, m)34 -- CH.sub.2 1 0 4-CO H H 104.about.105 (Cl) (KBr) (CDCl.sub.3) .delta.: 2.49(6H, s), 3.09(2H, d), OCH.sub.3 354 1725,1710 3.22(2H, d), 3.94(3H, s), (M.sup.+ + 1) 4.45(2H, s), 7.15(4H, s), 7.82.about.7.85(2H, m), 8.02.about. 8.05(2H,__________________________________________________________________________ m)
EXAMPLE 35
Preparation of 4-dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-4,5,6,7-tetrahydro-1-benzothiophene
15 ml of tetrahydrofuran containing 2.57 g of 4-dimethylamino-4-hydroxymethyl-4,5,6,7-tetrahydro-1-benzothiophen obtained in Example 1 was added to an ice-cooled suspension of 60% sodium hydride (0.54 g) in tetrahydrofuran. 15 ml of tetrahydrofuran containing 2.90 g of 3,4,5-trimethoxybenzyl chloride was further added to the reaction mixture, followed by refluxing under heat for 24 hours. After cooling, the reaction mixture was poured into hydrochloric acid solution, and washed with ether. The aqueous phase was added with a sodium hydroxyde solution for making the system basic, followed by extracting with chloroform. After the chloroform phase was washed with water and dried, the solvent was removed. The residue was purified by silica gel column chromatography to obtain 2.79 g of the title compound as a pale yellow oily product.
The melting point, IR, MS and NMR data are shown below.
IR(neat)cm.sup.-1 : 2950, 1595
MS(m/z): 391(M.sup.+)
NMR (CDCl.sub.3) .delta.: 1.70.about.2.00(4H, m), 2.24(6H, s), 2.68.about.2.76(2H, m), 3.54 (1H, d), 3.59 (1H, d), 3.80 (6H, s), 3.82 (3H, s), 4.41 (1H, d), 4.49 (1H, d), 6.46 (2H, s), 7.01 (1H, d), 7.15 (1H, d)
Hydrochloride of the present product: colorless crystals
Melting point: 172.degree.-173.degree. C. (ethanol - ethyl acetate)
The chemical formula is shown below. ##STR38##
EXAMPLES 36-47
Eleven kinds of compounds were obtained by following the procedure of Example 35. The chemical formulae, melting points, IR, MS and NMR data of these compounds are shown in Tables 3 and 4.
TABLE 3__________________________________________________________________________ ##STR39##Ex. Melting MS IRNo. R.sup.3 R.sup.4 R.sup.5 Q point .degree.C. (m/z) (cm.sup.-1) NMR__________________________________________________________________________36 4-Cl H H HCl 171.about.172 (Cl) (KBr) (CDCl.sub.3) .delta.: 1.64.about.1.85(2H, m), 2.03.about.2.19(1H, m), 336 2100.about.3100 2.43.about.2.60(4H, m), 2.68.about.3.05(5H, m), 3.65(1H, d), (M.sup.+ + 1) 1110 4.41(1H, d), 4.56(1H, d), 4.72(1H, d), 7.15.about.7.35 (5H, m), 7.84.about.7.92(1H, m), 12.29.about.12.56(1H, brs)37 4-OCH.sub.3 H H HCl 163.about.164 (Cl) (KBr) (CDCl.sub.3) .delta.: 164.about.1.75(2H, m), 2.04.about.2.10(1H, m), 332 2850.about.3100 2.47(3H, d), 2.52.about.2.56(1H, m), 2.75.about.2.90(2H, m), 3.01 (M.sup.+ + 1) 1610 (3H, d), 3.61(1H, d), 3.80(3H, s), 4.36(1H, d), 4.49(1H, d), 4.69(1H, d), 6.85.about.6.88(2H, m), 7.18.about.7.26(3H, m), 7.89(1H, d)38 3-OCH.sub.3 4-OCH.sub.3 H -- Oily (Cl) (Neat) (CDCl.sub.3) .delta.: 1.65.about.2.01(4H, m), 2.23(6H, s), 2.65.about.2.75(2H, Product 362 2750.about.3100 m), 3.45.about.3.60(2H, m), 3.82(3H, s), 3.86(3H, s), 4.39(1H, d), (M.sup.+ + 1) 1595 4.46(1H, d), 6.72.about.6.85(3H, m), 7.00(1H, d), 7.12(1H, d)39 4-CH.sub.3 H H -- Oily (Cl) (Neat) (CDCl.sub.3) .delta.: 1.73.about.1.93(4H, m), 2.23(6H, s), 2.32(3H, s), Product 316 2770.about.2930 2.70.about.2.72(2H, m), 3.54(2H, s), 4.38(1H, d), (M.sup.+ + 1) 1080 4.49(1H, d), 6.99.about.7.16(6H, m),40 H H H HCl 170.about.172 (Cl) (KBr) (CDCl.sub.3) .delta.: 1.71.about.1.77(2H, m), 2.04.about.2.13(1H, m), 302 2800.about.3125 2.48(3H, d), 2.55.about.2.61(1H, m), 2.69.about.2.88(2H, m), (M.sup.+ + 1) 2450.about.2625 3.03(3H, d), 3.65(1H, d), 4.43(1H, d), 4.55(1H, d), 4.76(1H, d), 7.19(1H, d), 7.29.about.7.37(5H, m), 7.90(1H,__________________________________________________________________________ d)
TABLE 4-1__________________________________________________________________________ ##STR40##Ex. Melting MS IRNo. Q Y m n R.sup.3 R.sup.4 R.sup.5 point .degree.C. (m/z) (cm.sup.-1) .sup.1 H-NMR__________________________________________________________________________41 HCl S 0 2 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 91.about.92 (EI) (KBr) (DMSO-d.sub.6) .delta.: 2.35.about.2.51(4H, m), 403 2850.about.3000 2.68.about.2.73(1H, m), 2.92(3H, d), (M.sup.+) 1595, 1510 3.04.about.3.21(2H, m), 3.63(3H, s), 3.75(6H, s), 3.92(1H, d), 4.17 (1H, d), 4.48(2H, dd), 6.60(2H, s), 7.16.about.7.30(3H, m), 8.12(1H, d)42 -- CH.sub. 2 1 1 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 Oily (EI) (Neat) (CDCl.sub.3) .delta.: 1.80.about.2.02(2H, m), Product 385 2930, 1590 2.41(6H, s), 2.57.about.3.00(4H, m), (M.sup.+) 1125 3.40(1H, d), 3.45(1H, d), 3.83(9H, s), 4.43(2H, s), 6.55(2H, s), 7.00.about.7.10(4H, m)43 1/2 CH.sub.2 1 0 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 133.about.138 (Cl) (KBr) (CDCl.sub.3) .delta.: 2.37(6H, s), 2.93(2H, d), (*) 372 1445, 1125 3.09(2H, d), 3.46(2H, s), (M.sup.+ + 1) 755 3.82(6H, s), 3.83(3H, s), 4.43(2H, s), 6.53(2H, s), 7.10.about.714(4H, m)44 -- CH.sub.2 1 0 4-CH.sub.3 H H Oily (Cl) (Neat) (CDCl.sub.3) .delta.: 2.33(3H, s), 2.34(6H, S), Product 296 2800.about.3050 2.92(2H, d), 3.06(2H, d), 3.43(2H, s) (M.sup.+ + 1) 1520 4.44(2H, s), 7.10.about.7.25(8H,__________________________________________________________________________ m) (*): Pamoic Acid
TABLE 4-2__________________________________________________________________________Ex. Melting MS IRNo. Q Y m n R.sup.3 R.sup.4 R.sup.5 point .degree.C. (m/z) (cm.sup.-1) .sup.1 H-NMR__________________________________________________________________________45 HCl CH.sub.2 0 2 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 184.about.187 (E1) (KBr) (CDCl.sub.3) .delta.: 1.72.about.2.05(3H, m), 385 2300.about.3050 2.45(3H, d), 2.70.about.2.78(3H, m) (M.sup.+) 1590,1115 3.11(3H, d), 3.64.about.3.85(10H, m), 4.38(1H, d), 4.53(1H, d), 5.56(2H, s), 7.12.about.7.40(3H, m), 8.35(1H, d), 12.29(1H, brs)46 HCl CH.sub.2 0 1 3-OCH.sub.3 4-OCH.sub.3 5-OCH.sub.3 73.about.74 (CI) (KBr) 3360 (CDCl.sub.3) .delta.: 2.35.about.2.53(2H, m), 371 2850.about.3030 2.58(3H, d), 2.90(3H, d), (M.sup.+) 1590 2.95.about.3.16(2H, m), 3.72(1H, d), 3.83(3H, s), 3.84(6H, s), 4.30(1H, d), 4.44(1H, d), 4.62(1H, d), 6.55(2H, s), 7.26.about.7.40(3H, m), 7.99.about.8.02(1H, m)47 -- CH.sub.2 1 0 4-OCH.sub.3 H H Oily (Cl) (Neat) (CDCl.sub.3) .delta.: 2.34(6H, s), Product 312 2780.about.3070 2.91(2H, d), 3.07(2H, d), 3.42(2H, s), (M.sup.+ + 1) 1090 3.78(3H, s), 4.41(2H, s), 6.82.about.6.85(2H, m), 7.11.about.7.24(6H,__________________________________________________________________________ m)
EXAMPLES 48-65
Compounds of the following nomenclature, chemical formulae, melting points, IR, MS land NMR data were obtained by following the procedure of Example 22.
EXAMPLE 48
4-Dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-cyclopenta[b]thiophene.HCl ##STR41## Melting point: 127.degree.-129.degree. C. IR(KBr)cm.sup.-1 : 1715, 1335, 1130
MS (m/z): (CI) 392 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 2.70.about.2.92 (7H, m), 3.05.about.3.20 (3H, m), 3.91 (3H, s), 3.97 (6H, s), 4.77 (1H, d), 4.37 (1H, d), 7.26 (1H, d), 7.37 (1H, d), 7.45 (2H, s)
EXAMPLE 49
4-Dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-cyclohepta[b]thiophene.HCl ##STR42## Melting point: 158.degree.-159.degree. C. IR(KBr)cm.sup.-1 : 1710
MS (m/z):(CI)420(M.sup.+ +1)
NMR (DMSO-d.sub.6) .delta.: 1.57.about.2.03(4H, m), 2.25.about.2.50 (2H, m), 2.67 (3H, d), 2.79 (3H, d), 2.84.about.2.96 (1H, m), 3.12.about.3.26 (1H, m), 3.74 (3H, s), 3.87 (6H, s), 4.80 (1H, d), 4.87 (1H, d), 7.33(2H, s), 7.41 (1H, d), 7.67 (1H, d), 10.60.about.11.00(1H, brs)
EXAMPLE 50
4-(N-ethyl-N-methyl)amino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-4,5,6,7-tetrahydro-1-benzothiophene ##STR43## Melting point: 75.degree.-76.degree. C. IR(KBr)cm.sup.-1 : 3000.about.2750, 1720, 1590
MS (m/z):(CI)420(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 0.99(3H, t), 2.32.about.2.44(2H, m), 2.73.about.2.79(2H, m), 3.88 (3H, s), 3.89 (6H, s), 4.42 (1H, d), 4.55 (1H, d), 7.01 (1H, d), 7.13 (1H, d), 7.19 (2H, s)
EXAMPLE 51
4-Dimethylamino-4-[(3,4,5-trimethoxyphenylacetoxy)-methyl]-4,5,6,7-tetrahydro-1-benzothiophene.HCl ##STR44##
Amorphous
IR(KBr)cm.sup.-1 : 1745, 1590
MS (m/z):(CI)420(M.sup.+ 1)
NMR (CDCl.sub.3) .delta.: 1.72-2.10 (4H, m), 2.53 (3H, brs), 2.65.about.2.93 (5H, m), 3.72.about.3.90 (11H, m), 4.56.about.4.73 (2H, m), 6.61 (2H, s), 7.20 (1H, d), 7.80 (1H, d), 12.41 (1H, brs)
EXAMPLE 52
4-Dimethylamino-4-[[3-(3,4,5-trimethoxyphenyl)propanoyloxy]methyl]-4,5,6,7-tetrahydro-1-benzothiophene.fumaric acid salt ##STR45## Melting point: 157.degree.-158.degree. C. IR (KBr)cm.sup.-1 : 2940.about.2835, 1745, 1590
MS (m/z): (EI) 433 (M.sup.+)
NMR (DMSO-d.sub.6) .delta.: 1.55.about.1.92(4H, m), 2.14 (6H, s), 2.58.about.2.78(6H, m), 3.61 (3H, s), 3.73 (6H, s), 4.10 (1H, d), 4.31 (1H, d), 6.49 (2H, s), 6.61 (2H, s), 7.02 (1H, d), 7.21 (1H, d)
EXAMPLE 53
4-Dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-4,5,6,7-tetrahydro-1-benzofuran.maleic acid salt ##STR46## Melting point: 121.degree.-122.degree. C. IR (KBr)cm.sup.-1 : 1730
MS (m/z):(CI)390(M.sup.+ +1)
NMR (DMSO-d.sub.6) .delta.: 1.82.about.2.26(4H, m), 2.52.about.2.90 (8H, m), 3.15.about.3.50 (2H, brs), 3.76 (3H, s), 3.85 (6H, s), 4.50 (1H, d), 4.87 (1H, d), 6.04 (2H, s), 6.72(1H, d), 7.25 (2H, s), 7.67(1H, d)
EXAMPLE 54
5-Dimethylamino-5-[(3,4,5-trimethoxybenzoyloxy)methyl]-5,6,7,8-tetrahydro-quinoline.HCl ##STR47## Melting point: 197.degree.-205.degree. C. IR (KBr)cm.sup.-1 : 1720
MS (m/z): (CI) 401 (M.sup.+ +1)
NMR (DMSO-d.sub.6) .delta.: 1.82.about.2.14(2H, m), 2.20.about.2.40(2H, m), 2.54(3H, brs), 2.85.about.3.15 (5H, m), 3.74 (3H, s), 3.87 (6H, s), 4.80 (1H, d), 4.90 (1H, d), 4.00.about.6.00 (2H, brs), 7.28 (2H, s), 7.50.about.7.60 (1H, m), 8.58.about.8.66 (1H, m), 8.92.about.9.02 (1H, m), 11.76.about.12.00(1H, brs)
EXAMPLE 55
1-Dimethylamino-1-[(3,4,5-trimethoxybenzoyloxy)methyl]cycloheptabenzene ##STR48##
Oily product
IR(neat)cm.sup.-1 : 2940-2785, 1720, 1590
MS (m/z): (CI)414(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.35.about.1.55(1H, m), 1.60.about.2.08(5H, m), 2.32(6H, s), 2.65 (1H, ddd), 3.40 (1H, ddd), 3.83 (6H, s), 3.89 (3H, s), 4.61 (1H, d), 4.77 (1H, d), 7.08.about.7.15 (3H, m), 7.25 (2H, s), 7.51.about.7.55 (1H, m)
EXAMPLE 56
2-Dimethylamino-2-[(3,4,5-trimethoxybenzoyloxy)methyl]-1,2,3,4-tetrahydronaphthalene.HCl ##STR49## Melting point: 160.degree.-162.degree. C. IR(KBr) cm.sup.-1 : 1710, 1590
MS (m/z): (EI) 399 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.42.about.2.51(2H, m),2.80.about.3.07(2H, m),2.96(6H, s), 3.13 (1H, d), 3.58 (1H, d), 3.92 (3H, s), 3.94 (6H, s), 4.47 (1H, d), 4.55 (1H, d), 7.08.about.7.23 (4H, m), 7.33 (2H, s), 12.79 (1H, brs)
EXAMPLE 57
6-Chloro-4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzopyran.HCl ##STR50## Melting point: 205.degree.-206.degree. C. IR(KBr) cm.sup.-1 : 1715, 1590, 1335
MS (m/z): (EI) 435 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.34 (1H, m), 2.48 (1H, m), 2.69 (3H, d), 3.01 (3H, d), 3.91 (3H, s), 3.94 (6H, s), 4.19 (1H, m), 4.40 (1H, m), 5.02 (1H, d), 5.09 (1H, d), 6.91 (1H, d), 7.28 (1H, dd), 7.37 (2H, s), 8.38 (1H, d)
EXAMPLE 58
4-Dimethylamino-6-fluoro-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzopyran.HCl ##STR51## Melting point: 193.degree.-195.degree. C. IR(KBr) cm.sup.-1 : 3015.about.2835, 1715, 1595
MS (m/z): (EI) 419 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.27.about.2.36(1H, m), 2.39.about.2.53(1H, m), 2.67(3H, d), 3.02 (3H, d), 3.91 (3H, s), 3.93 (6H, s), 4.18 (1H, ddd), 4.32.about.4.42 (1H, m), 5.02 (1H, d), 5.12 (1H, d), 6.93 (1H, dd), 7.06 (1H, ddd), 7.35 (2H, s), 8.19 (1H, dd), 13.25 (1H, brs)
EXAMPLE 59
4-Dimethylamino-6-methoxy-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzopyran.HCl ##STR52## Melting point: 194.degree.-196.degree. C. IR (KBr) cm.sup.-1 : 1720, 1590, 1505
MS (m/z): (EI) 431 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.19.about.2.40 (2H, m), 2.60 (3H, d), 3.06 (3H, d), 3.88 (3H, s), 3.91 (9H, s), 4.11.about.4.22 (1H, m), 4.25.about.4.35 (1H, m), 5.19 (2H, s), 6.84.about.6.94 (2H, m), 7.31 (2H, s), 7.92 (1H, d) 13.17 (1H, brs)
EXAMPLE 60
4-Dimethylamino-6-methyl-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzopyran.HCl ##STR53## Melting point: 205.degree.-206.degree. C. IR(KBr) cm.sup.-1 : 1715, 1505, 1330
MS (m/z): (EI) 415 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.34 (3H, s), 2.37 (2H, m), 2.63 (3H, d), 3.01 (3H, d), 3.91 (3H, s), 3.93 (6H, s), 4.16 (1H, m), 4.33 (1H, m), 5.09 (1H, d), 5.14 (1H, d), 6.85 (1H, d), 7.13 (1H, dd), 7.35 (2H, s), 8.06 (1H, d)
EXAMPLE 61
4-Dimethylamino-2,2-dimethyl-4-[(3,4,5trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzopyran ##STR54## Melting point: 114.degree.-115.degree. C. IR(KBr)cm.sup.-1 : 1720
MS (m/z) : (EI) 429 (M.sup.+)
NMR (CHCl.sub.3) .delta.:1.35(3H, s), 1.37(3H, s), 1.94(1H, d), 2.16(1H, d), 2.24 (6H, s), 3.89 (6H, s), 3.90 (3H, s), 4.46 (1H, d), 4.56 (1H, d), 6.81 (1H, dd), 6.93 (1H, dt), 7.15 (1H, ddd), 7.26 (2H, s), 7.60 (1H, dd)
EXAMPLE 62
6-Chloro-4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl ##STR55## Melting point: 193.degree.-194.degree. C. IR (KBr) cm.sup.-1 : 1715, 1330, 1215
MS (m/z): (EI) 451 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.55(1H, m), 2.73(3H, brs),2.81(1H, m), 2.98(1H, m), 3.03 (3H, brs), 3.25 (1H, m), 3.91 (3H, s), 3.94 (6H, s), 4.96 (1H, d), 5.04 (1H, d), 7.19 (1H, d), 7.26 (1H, dd), 7.33 (2H, s), 8.58 (1H, d)
EXAMPLE 63
4-Dimethylamino-6-methoxy-4-[(2,3,4-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl ##STR56## Melting point: 189.degree.-190.degree. C. IR(KBr) cm.sup.-1 : 1720, 1240, 1130
MS (m/z): (EI) 447 (M.sup.+)
NMR (CDCl.sub.3) .delta.:2.44(1H, m), 2.63 (3H, d), 2.71(1H, m), 2.89(1H, m) 3.08 (3H, d), 3.25 (1H, m), 3.90 (8H, s), 3.91 (3H, s), 3.94 (3H, s), 5.07 (1H, d), 5.17 (1H, d), 6.88 (1H, dd), 7.13 (1H, d), 7.26 (2H, s), 8.08 (1H, d)
EXAMPLE 64
4-Dimethylamino-6-methyl-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl ##STR57## Melting point: 191.degree.-192.degree. C. IR(KBr) cm.sup.-1 : 1720, 1335, 1130
MS (m/z): (EI) 431 (M.sup.+)
NMR (CDCl.sub.3) .delta.:2.38 (3H, s), 2.49 (1H, m), 2.65 (3H, d), 2.71 (1H, m), 2.93 (1H, m), 3.03 (3H, d), 3.24 (1H, m), 3.91 (3H, s), 3.92 (6H, s), 5.02 (1H, d), 5.10 (1H, d), 7.11 (2H, m), 7.29 (2H, m), 8.29 (1H, m)
EXAMPLE 65
4-Dimethylamino-1-methyl-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-1,2,3,4-tetrahydroquinoline ##STR58## Melting point: 85.degree.-86.degree. C. IR (KBr) cm.sup.-1 : 1715, 1330, 1125
MS (m/z): (EI) 414(M.sup.+)
NMR (CDCl.sub.3) .delta.:1.88.about.2.05 (1H, m), 2.16.about.2.35 (1H, m), 2.32 (6H, s), 2.88 (3H, s), 3.15.about.3.32 (2H, m), 3.86 (6H, s), 3.89 (3H, s), 4.42 (1H, d), 4.67 (1H, d), 6.61.about.6.71 (2H, m), 7.10.about.7.17 (1H, m), 7.19 (2H, s), 7.56(1H, dd)
EXAMPLE 66
Preparation of 4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran-1-oxide
The title compound was obtained via the following procedure.
1.13 g of 4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl obtained in Example 30 was dissolved in 110 ml of methylene chloride, to which 525 mg of metachloroperbenzoic acid (70%) was added, followed by stirring for 10 minutes. The reaction mixture was added with saturated aqueous sodium bicarbonate solution, and was subjected to separation. The methylene chloride phase was condenced, and purified through a silica gel column to obtain 739 mg of the title compound as colorless crystals.
The melting point, IR, MS and NMR data are shown below.
Melting point: 146.degree.-148.degree. C.
IR (KBr) cm.sup.-1 : 1710, 1330, 1220, 1125, 1045
MS (m/z): (EI) 433 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.03(1H, ddd), 2.34(6H, s), 2.85.about.3.15(2H, m), 3.32 (1H, ddd), 3.84 (6H, s), 3.88 (3H, s), 4.40 (1H, d), 4.46 (1H, d), 7.02 (2H, s), 7.46 (1H, ddd), 7.55 (1H, ddd), 7.80 (1H, dd), 8.00 (1H, dd)
The chemical formula is shown below. ##STR59##
EXAMPLE 67
Preparation of 4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl] -2,3-dihydro-4H-1-benzothiopyran-1,1-dioxide
The title compound was obtained via the following procedure.
1.13 g of 4-dimethylamino-4-[(3,4,5-trimethoxybenzoyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl obtained in Example 30 was added with 11 ml of 30% hydrogen peroxide and 11 ml of acetic acid, and stirred for 20 hours at room temperature. The reaction solution was neutralized, extracted with methylene chloride, and purified through a silica gel column to obtain 165 mg of the title compound as colorless crystals.
Melting point: 152.degree. C.
MS (m/z):(E1)449(M+)
IR(KBr)cm.sup.-1 : 1715, 1305, 1220, 1135, 1130, 1000
NMR (CDCl.sub.3) .delta.: 2.32 (6H, s), 2.44.about.2.64 (1H, m), 2.85.about.3.03 (1H, m), 3.29.about.3.48 (1H, m), 3.53.about.3.74 (1H, m), 3.83 (6H, s), 3.86 (3H, s), 4.55 (2H, s), 7.00 (2H, s), 7.48 (1H, ddd), 7.58 (1H, ddd), 7.88 (1H, dd), 7.97 (1H, dd) ##STR60##
EXAMPLES 68-86
The compounds of the following nomenclature, chemical formulas, melting points, IR, MS and NMR were obtained according to the procedure of Example 35.
EXAMPLE 68
4-Dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]cyclopenta[b]thiophene ##STR61##
Oily pruduct
IR(neat)cm.sup.-1 1460, 1235, 1125
MS (m/z):(CI)378(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 2.07.about.2.30(1H, m), 2.21 (6H, s), 2.49.about.2.71 (1H, m), 2.80.about.2.94(2H, m), 3.51 (1H, d), 3.59(1H, d), 3.80(6H, s), 3.82 (3H, s), 4.48 (2H, s), 6.49 (2H, s), 6.98 (1H, d), 7.16(1H, d)
EXAMPLE 69
4-Dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]cyclohepta[b]thiophene.HCl ##STR62## Melting point: 107.degree.-109.degree. C. IR (KBr) cm.sup.-1 : 1150
MS (m/z): (CI) 406 (M.sup.+ +1)
NMR (DMSO-d.sub.6) .delta.: 1.45.about.1.97 (4H, m), 2.17.about.2.35 (2H, m), 2.55 (3H, d), 2.75 (3H, d), 2.75.about.2.90 (1H, m), 3.09.about.3.23 (1H, m), 3.64 (3H, s), 3.77 (6H, s), 3.79 (1H, d), 4.13 (1H, d), 4.47 (1H, d), 4.53 (1H, d), 6.64 (2H, s), 7.37 (1H, d), 7.49(1H, d), 10.00.about.10.20 (1H, brs)
EXAMPLE 70
4-(N-ethyl-N-methyl)amino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-4,5,6,7-tetrahydro-1-benzothiophene.fumaric acid salt ##STR63## Melting point: 135.degree.-137.degree. C. IR (KBr) cm.sup.-1 : 3000.about.2475, 1700, 1595
MS (m/z): (EI) 405 (M.sup.+)
NMR (DMSO-d.sub.6) .delta.: 0.99 (3H, t), 1.70.about.1.98 (4H, m), 2.33 (3H, s) 2.38.about.2.61 (2H, m), 2.66.about.2.75 (2H, m), 3.59.about.3.76 (11H, m), 4.33.about.4.44 (2H, m), 6.55 (2H, s), 6.59 (2H, s), 7.13 (1H, d), 7.25 (1H, d)
EXAMPLE 71
4-Dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-4,5,6,7-tetrahydro-1-benzofuran ##STR64##
Oily product
IR(neat)cm.sup.-1 : 1130
MS (m/z):(CI)376(M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 1.58.about.2.00(4H, m), 2.30(6H, s), 2.51(2H, m), 3.48 (1H, d), 3.57 (1H, d), 3.80 (6H, s), 3.83 (3H, s), 4.47 (2H, s), 6.50 (2H, s), 6.51 (1H, d), 7.23 (1H, d)
EXAMPLE 72
5-Dimethylamino-5-[(3,4,5-trimethoxybenzyloxy)methyl]-5,6,7,8-tetrahydroquinoline ##STR65##
Oily product
IR(neat)cm.sup.-1 : 1130
MS (m/z):(EI)386(M.sup.+)
NMR (CDCl.sub.3) .delta.: 1.80.about.2.00(4H, m), 2.22 (6H, s), 2.83.about.2.93 (2H, m) 3.50 (1H, d), 3.58 (1H, d), 3.78 (6H, s), 3.82 (3H, s), 4.33 (1H, d), 4.41 (1H, d), 6.39 (2H, s), 7.11 (1H, dd), 8.03 (1H, dd), 8.38 (1H, dd)
EXAMPLE 73
1-Dimethylamino-1-[(3,4,5-trimethoxybenzyloxy)methyl]cycloheptabenzene.HCl ##STR66## Melting point: 103.degree.-107.degree. C. IR (KBr) cm.sup.-1 : 3320, 2940, 1595
MS (m/z): (EI)399(M.sup.+)
NMR (CDCl.sub.3) .delta.:1.45.about.1.80(2H, m), 1.84.about.2.03 (2H, m), 2.12.about.2.24(1H, m) 2.54 (3H, d), 2.47.about.2.63 (1H, m), 2.64.about.2.75(1H, m), 3.03 (3H, d), 3.11.about.3.25 (1H, m), 3.74 (1H, d), 3.83 (3H, s), 3.85 (6H, s), 4.43 (1H, d), 4.62.about.4.73 (2H, m), 6.56 (2H, s), 7.14(1H, d), 7.25.about.7.32 (1H, m), 7.37.about.7.45(1H, m), 8.23(1H, d)
EXAMPLE 74
2-Dimethylamino-2-[(3,4,5-trimethoxybenzyloxy)methyl]-1,2,3,4-tetrahydronaphthalene.fumaric acid salt ##STR67## Melting point: 144.degree.-146.degree. C. IR(KBr)cm.sup.-1 : 2950.about.2840, 1715, 1680
MS (m/z): (EI) 385 (M.sup.+)
NMR (DMSO-d.sub.6) .delta.: 1.83.about.2.03 (2H, m), 2.50 (6H, s), 2.59.about.2.88 (2H, m), 2.82 (1H, d), 3.00 (1H, d), 3.44.about.3.53 (2H, m), 3.64 (3H, s), 3.75 (6H, s), 4.41 (2H, s), 6.55 (2H, s), 6.62 (2H, s), 7.07 (4H, s)
EXAMPLE 75
4-Dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzopyran . 2-(4-hydroxybenzoyl)benzoic acid salt ##STR68## Melting point: 140.degree.-141.degree. C. IR(KBr) cm.sup.-1 : 1660, 1130
MS (m/z) : (CI) 388 (M.sup.+ +1)
NMR (DMSO-d.sub.6) .delta.: 1.90.about.2.00(1H, m), 2.06.about.2.16 (1H, m),2.16(6H, s), 3.10.about.3.60 (1H, brs), 3.62 (3H, s), 3.68 (1H, d), 3.70 (6H, s), 3.72 (1H, d), 4.08.about.4.26 (2H, m), 4.33 (1H, d), 4.40 (1H, d), 6.50 (2H, s), 6.74 (1H, dd), 6.78.about.6.90 (3H, m), 7.07.about.7.15 (1H, m), 7.34 (1H, dd), 7.44.about.7.54 (3H, m), 7.57.about.7.73(2H, m), 7.95(1H, dd), 10.30.about.10.70(1H, brs)
EXAMPLE 76
6-Chloro-4-dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzopyran.HCl ##STR69## Melting point: 176.degree.-177.degree. C. IR (KBr) cm.sup.-1 : 1595, 1510, 1130
MS (m/z): (EI) 421 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.25(1H, m), 2.53(3H, d), 2.61(1H, m), 3.06(3H, d), 3.83 (3H, s), 3.85 (6H, s), 3.87 (1H, d), 3.97 (1H, m), 4.35 (1H, m), 4.41 (1H, d), 4.59 (1H, d), 4.70 (1H, d), 6.53 (2H, s), 6.84 (1H, d), 7.23 (1H, dd), 8.35 (1H, d)
EXAMPLE 77
4-Dimethylamino-6-fluoro-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzopyran . 2-(4-hydroxybenzoyl)benzoic acid salt ##STR70## Melting point: 162.degree.-163.degree. C. IR(KBr) cm.sup.-1 : 3455, 1660, 1590
MS (m/z):(EI)405(M.sup.+)
NMR (DMSO-d.sub.6) .delta.: 1.84.about.1.95(1H, m), 2.09.about.2.22 (1H, m), 2.18(6H, s), 3.63 (3H, s), 3.64.about.3.72 (2H, m), 3.71 (6H, s), 4.08.about.4.22 (2H, m), 4.35 (1H, d), 4.41 (1H, d), 6.50 (2H, s), 6.74.about.6.84 (3H, m), 6.92.about.7.02 (1H, m), 7.23.about.7.35(2H, m), 7.46.about.7.52 (2H, m), 7.60(1H, ddd), 7.68 (1H, ddd), 7.95 (1H, dd), 10.36 (1H, brs)
EXAMPLE 78
4-Dimethylamino-6-methoxy-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzopyran.HCl ##STR71## Melting point: 76.degree.-79.degree. C. IR(KBr)cm.sup.-1 : 1595, 1500
MS (m/z): (EI) 417 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.17(1H, ddd),2.48 (3H, d), 2.57.about.2.66(1H, m), 3.08(3H, d), 3.81.about.3.99 (14H, m), 4.23.about.4.32 (1H, m), 4.39 (1H, d), 4.64.about.4.75 (2H, m), 6.53 (2H, s), 6.79 (1H, d), 6.86 (1H, dd), 7.88 (1H, d), 12.66 (1H, brs)
EXAMPLE 79
4-Dimethylamino-6-methyl-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzofuran.HCl ##STR72## Melting point: 75.degree.-76.degree. C. IR(KBr)cm.sup.-1 : 1590, 1510, 1225
MS (m/z): (EI) 401 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.20 (1H, m), 2.34 (3H, s), 2.47 (3H, d), 2.62 (1H, m), 3.08 (3H, d), 3.83 (3H, s), 3.85 (6H, s), 3.88 (1H, d), 3.96 (1H, m), 4.30 (1H, m), 4.39 (1H, d), 4.64 (1H, d), 4.72 (1H, d), 6.54 (2H, s), 6.77 (1H, d), 7.07 (1H, dd), 8.05(1H, d)
EXAMPLE 80
4-Dimethylamino-2,2-dimethyl-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzopyran ##STR73##
Oily product
IR(neat)cm.sup.1 : 1590, 1130, 760
MS (m/z): (EI) 415 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 1.23(3H, s), 1.42(3H, s), 1.96(1H, d), 2.07 (1H, d), 2.18 (6H, s), 3.51 (1H, d), 3.76 (1H, d), 3.81 (6H, s), 3.83 (3H, s), 4.44 (2H, s), 6.51 (2H, s), 6.79 (1H, dd), 6.90 (1H, ddd), 7.13 (1H, ddd), 7.50 (1H, dd)
EXAMPLE 81
6-Chloro-4-dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl ##STR74## Melting point: 135.degree.-136.degree. C. IR (KBr) cm.sup.-1 : 1590, 1465, 1130
MS (m/z): (EI) 437 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.16 (1H, m), 2.55 (3H, d), 2.96 (2H, m), 3.02 (1H, m), 3.09 (3H, d), 3.81 (1H, d), 3.83 (3H, s), 3.86 (6H, s), 4.40 (1H, d), 4.54 (1H, d), 4.69 (1H, d), 6.54 (2H, s), 7.11 (1H, d), 7.20 (1H, dd), 8.59 (1H, d)
EXAMPLE 82
4-Dimethylamino-6-methoxy-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl ##STR75## Melting point: 91.degree.-92.degree. C. (KBr) cm.sup.-1 : 1120
MS(m/z): (EI)433(M.sup.+)
(DMSO-d.sub.6) .delta.: 2.30.about.2.50 (4H, m), 2.64.about.2.76 (1H, m), 2.92 (3H, d), 2.97.about.3.19 (2H, m), 3.64 (3H, s), 3.75 (6H, s), 3.77 (3H, s), 3.91 (1H, d), 4.19 (1H, d), 4.45 (1H, d), 4.51 (1H, d), 6.61 (2H, s), 6.91 (1H, dd), 7.14 (1H, d), 7.78 (1H, d), 10.95.about.11.08(1H, brs)
EXAMPLE 83
4-Dimethylamino-6-methyl-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran.HCl ##STR76## Melting point: 136.degree.-137.degree. C. IR(KBr)cm.sup.-1 : 1590, 1120, 1100
MS (m/z): (EI) 417 (M.sup.+)
NMR (CDCl.sub.3) .delta.:2.12.about.2.30 (1H, m), 2.38 (3H, s), 2.48 (3H, d), 2.79.about.2.95 (1H, m), 2.94.about.3.10 (2H, m), 3.10 (3H, d), 3.81(1 H, d), 3.84 (3H, s), 3.86 (6H, s), 4.37 (1H, d), 4.59(1 H, d), 4.71 (1H, d), 6.54 (2H, s), 7.05 (2H, s), 8.32(1H, s)
EXAMPLE 84
4-Dimethylamino-1-methyl-4-[(3,4,5-trimethoxybenzyloxy)methyl]-1,2,3,4-tetrahydroquinoline ##STR77##
Oily product
IR(neat)cm.sup.-1 : 1505, 1330, 1130
MS (m/z):(EI)400(M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.00.about.2.19(2H, m), 2.29(6H, s), 2.85(3H, s), 3.10.about.3.27 (2H, m), 3.64 (2H, s), 3.80 (6H, s), 3.82 (3H, s), 4.36 (1H, d), 4.43 (1H, d), 6.46 (2H, s), 6.57.about.6.69 (2H, m), 7.08.about.7.14 (1H, m), 7.47 (1H, dd)
EXAMPLE 85
4-Dimethylamino-4-[(3,4,5-trimethoxybenzyloxy)methyl]-2,3-dihydro-4H-1-benzothiopyran-1-oxide ##STR78##
Oily product
IR(neat)cm.sup.-1 : 1590, 1460, 1130
MS (m/z): (CI) 420 (M.sup.+ +1)
NMR (CDCl.sub.3) .delta.: 2.11 (1H, ddd), 2.26 (6H, s), 2.88 (1H, ddd), 3.05 (1H, ddd), 3.30 (1H, ddd), 3.50 (1H, d), 3.67 (1H, d), 3.77 (6H, s), 3.81 (3H, s), 4.22 (1H, d), 4.35 (1H, d), 6.29 (2H, s), 7.41 (1H, ddd), 7.51 (1H, ddd), 7.74(1H, dd), 7.91 (1H, dd)
EXAMPLE 86
4-Dimethylamino-4-[(3,4,5-trimethoxybenzyloxy )methyl]-2,3-dihydro-4H-1-benzothiopyran-1,1-dioxide ##STR79##
Amorphous
IR(KBr)cm.sup.-1 : 1590, 1290, 1130
MS (m/z): (EI) 435 (M.sup.+)
NMR (CDCl.sub.3) .delta.: 2.24(6H, s), 2.52(1H, ddd), 2.77 (1H, ddd), 3.33(1H, ddd), 3.61 (1H, d), 3.78 (1H, d), 3.85.about.3.80 (1H, m), 3.79 (6H, s), 3.82 (3H, s), 4.25 (1H, d), 4.37 (1H, d), 7.26 (2H, s), 7.44 (1H, ddd), 7.52 (1H, ddd), 7.80 (1H, dd), 7.93 (1H, dd)
EXAMPLE 87
Formulation of Preparation Example 1
______________________________________Compound of Example 22 20 gLactose 315 gCorn starch 125 gCrystalline cellulose 25 g______________________________________
The ingredients indicated above were blended to form a uniform mixture, to which 200 ml of 7.5% aqueous hydroxypropylcellulose solution was added, and then passed an extruder equipped with a screen of 0.5 mm in diameter to prepare granules. Immediately thereafter, the granules were rounded with a marumerizer and dried to obtain a granule preparation.
EXAMPLE 88
Formulation of Preparation Example 2
______________________________________Compound of Example 29 20 gLactose 100 gCorn starch 36 gCrystalline cellulose 30 gCarboxymethylcellulose calcium 10 gMagnesium stearate 4 g______________________________________
The ingredients indicated above were blended to form a uniform mixture, and prepared into tablets each weighing 200 mg with a single-shot tableting machine equipped with a pestle having a diameter of 7.5 mm.
EXAMPLE 89
Formulation of Preparation Example 3
______________________________________Compound of Example 41 100 mgSodium acetate 2 mgAcetic acid (to adjust pH to 5.8) suitable amountPurified water suitable amountTotal: 10 ml/vial______________________________________
The above formulation was prepared into an injection preparation by a method known per se.
TEXT EXAMPLES
Test 1 Accelerating Action of Gastrointestinal Motility
The test was performed according to the method of Itoh et al. (Am. J. Dig. Dis. 22, 117-124, 1977). In detail, laparotomy was made to male-dogs (body weight: 9-10 kg) under anesthesia with Nembutal (30 mg/kg, i.v.). Force transducers (F-121S, manufactured by Star Medical Co.) were implanted in the direction so that the contraction of circular muscle could be monitored on serosa of gastric body, gastric antrum (about 3 cm proximal to the annular pylorus), duodenum and jejunum. In addition, a silicone tube was inserted from the right external carotid artery, and the tube was indwelled in the superior vena cava. The transducers and the silicone tube were subcutaneously exteriorized out of the body.
The dog was submitted to the test with consciousness and without restraint after about 3 weeks from the operation.
The contractile signals from each transducer were amplified with an amplifier (RTA-1200; manufactured by Nippon Koden Co.), and recorded with a recording apparatus and a computer. The test compounds were dissolved in the saline and intravenously administered (0.5 ml/kg) to the dog through a silicone tube about 10 minutes after the termination of the gastrointestinal inter digestive migrating contractions(IMC) in the antrum.
Evaluation Method
Contracle signals amplified as analog voltage were converted to digital signals, which were integrated to calculate the motor activity. The quantity of work which allows to maintain the 1 V variation in voltage for 6 seconds was counted as 1 unit, and the moter index in the period of 30 minutes after the administration of the test compound was obtained. The thus calculated moter index was compared with the moter index obtained after the saline was administered.
The results are shown in Table 5.
TABLE 5______________________________________ Moter IndexTest Compounds Dose (mg/Kg) Ratio*______________________________________Example 22 3 2.2Example 29 3 1.7Example 30 3 1.6Example 35 3 1.2Example 41 3 2.1Example 49 3 1.3Example 69 3 1.6Example 75 3 1.2Control compound 3 1.0(trimebutine maleate)______________________________________ *The moter index of the control compound = 1
Test 2 Toxicity Test
Groups of 4-5 week old ICR mice, each group consisting of 6 mice, were provided for the test. The compounds obtained in Examples 22, 29 and 41 were respectively suspended in 5% gum arabic and each was orally administered to the mice at a dose of 500 mg/kg. The mice were observed for 1 week. No death was found in any of the dosage groups.
INDUSTRIAL APPLICABILITY
Since the compounds of present invention have the activity of accelerating the gastrointestinal contraction, in other words, they improve the gastrointestinal motility significantly, while they are very safe, they have the utility in the medical field of treating the gastrointestinal disorders and the like.

Number	Date	Country
2803582	Aug 1979	DEX
53-84955	Jul 1978	JPX
637363	Jul 1983	CHX

Trialkylamine derivative and ameliorant for digestive tract movement containing the same

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Aboul-Enein et al., Chemical Abstracts, vol. 110, No. 15, abstract No. 128064f, 1988.
Sarges et al., J. Med. Chem., vol. 16, No. 9, 1973.