Claims
- 1. A member selected from the group consisting of a compound of the formula ##STR188## wherein X is chlorine;
- Y is 2-chlorophenyl, 2-fluorophenyl or 2-trifluoromethylphenyl;
- R is hydrogen or methyl, and
- R.sup.1 is bromine, mercapto, mercaptomethyl, methylthio, methoxymethyl, acetoxymethyl, hydroxymethyl, chloromethyl, methylthiomethyl, benzyldithiomethyl, dimethylaminomethyl, dimethylaminoethyl, dimethylaminopropyl, dimethylaminoethoxymethyl, dimethylaminopropyloxymethyl or dimethylaminoethylthiomethyl
- or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound claimed in claim 1, namely 1-acetoxymethyl-6-(2-chlorophenyl)-8-chloro-4H,6H-(1,2,4)triazolo[4,3-a][4,1]benzoxazepine.
- 3. A compound claimed in claim 1, namely 1-methoxymethyl-6-(2-chlorophenyl)-8-chloro-4H,6H-(1,2,4)triazolo[4,3-a][4,1]benzoxazepine.
- 4. A compound claimed in claim 1, namely 1-hydroxymethyl-6-(2-chlorophenyl)-8-chloro-4H,6H-(1,2,4)triazolo[4,3-a][4,1]benzoxazepine.
- 5. A compound claimed in claim 1, namely 1-(N,N-dimethylamino)methyl-6-(2-chlorophenyl)-8-chloro-4H,6H-(1,2,4)-triazolo[4,3-a][4,1]benzoxazepine.
- 6. A pharmaceutical composition having central nervous system activity comprising an effective amount of a compound or salt thereof according to claim 1 as an effective ingredient together with a pharmaceutically acceptable carrier, diluent and/or excipient.
Priority Claims (2)
Number |
Date |
Country |
Kind |
55-52185 |
Apr 1980 |
JPX |
|
55-136646 |
Sep 1980 |
JPX |
|
Parent Case Info
This application is a division of application Ser. No. 250,299, filed Apr. 2, 1981 (now U.S. Pat. No. 4,374,842).
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3681343 |
Hester |
Aug 1972 |
|
4297280 |
Hirai et al. |
Oct 1981 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
2947773 |
Jun 1980 |
DEX |
55-72177 |
May 1980 |
JPX |
2046729 |
Nov 1980 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Hirai et al., Chem. Abstracts, vol. 93, Abstract No. 204705p (1980). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
250299 |
Apr 1981 |
|