Claims
- 1. A compound of formula ##STR18## or an acid addition salt thereof; in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, halogen, C.sub.1-4 haloalkyl, nitro, C.sub.1-4 alkoxy, C.sub.1-4 haloalkoxy, C.sub.1-4 alkylthio or phenylsulphonyl; in which R.sup.5 is a group of the formula ##STR19## where R.sup.7 is hydrogen or C.sub.1-6 alkyl, R.sup.8 is hydrogen or C.sub.1-4 alkyl and n is 0 or 1, provided that when R.sup.7 is hydrogen n is 0; and in which R.sup.6 is attached to the 1, 2 or 3 position of the triazole ring and is hydrogen, C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, phenyl, benzyl or acyl.
- 2. A compound according to claim 1 in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, halogen or C.sub.1-4 haloalkyl, R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl or C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, R.sup.7 is hydrogen or C.sub.1-4 alkyl, R.sup.8 is hydrogen and n is 0.
- 3. A compound according to claim 2 in which R.sup.6 is hydrogen or C.sub.1-4 alkyl.
- 4. A compound according to claim 3 of the formula ##STR20## in which R.sup.2 and R.sup.3 independently represent hydrogen or halogen, R.sup.6 is C.sub.1-4 alkyl and R.sup.7 is C.sub.1-4 alkyl.
- 5. A compound according to claim 4 in which the R.sup.6 group is attached to the triazole ring at the 2-position.
- 6. A pharmaceutical formulation useful for treating CNS disorders comprising an effective amount of a compound as defined in claim 1, or a pharmaceutically-acceptable acid addition salt thereof, and a pharmaceutically-acceptable diluent or carrier therefor.
- 7. A method of treating an animal including a human being, suffering from or susceptible to a CNS disorder, which comprises administering a pharmaceutically-effective amount of a compound according to claim 1 or a pharmaceutically-acceptable acid addition salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8039659 |
Dec 1980 |
GBX |
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Parent Case Info
This application is a division of application Ser. No. 327,143, filed Dec. 3, 1981, now U.S. Pat. No. 4,431,589.
US Referenced Citations (17)
Foreign Referenced Citations (2)
Number |
Date |
Country |
3016 |
Jul 1979 |
EPX |
2707270 |
Aug 1978 |
DEX |
Non-Patent Literature Citations (3)
Entry |
Indian J. Chem., 14B, 394-396 (1976). |
Derwent 21412 D/12. |
J. Heterocyclic Chemistry, 16, 935 (1979). |
Divisions (1)
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Number |
Date |
Country |
Parent |
327143 |
Dec 1981 |
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