Claims
- 1. A hydrophilic polymeric medical article which has been impregnated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophilic polymer; (ii) between 1 and 5 percent of chlorhexidine, wherein the chlorhexidine consists essentially of a mixture of chlorhexidine free base and a chlorhexidine salt; and (iii) between 0.5 and 5 percent of triclosan.
- 2. The medical article of claim 1 which is fabricated from a hydrophilic polymer selected from the group consisting of natural rubber latex and biomedical polyurethane.
- 3. The medical article of claim 1 wherein the hydrophilic polymer in the treatment solution is a biomedical polyurethane.
- 4. The medical article of claim 2 wherein the hydrophilic polymer in the treatment solution is a biomedical polyurethane.
- 5. A hydrophilic polymeric medical article which has been impregnated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophobic polymer; (ii) between 1 and 5 percent of chlorhexidine, wherein the chlorhexidine consists essentially of a mixture of chlorhexidine free base and a chlorhexidine salt; and (iii) between 0.5 and 5 percent of triclosan.
- 6. The medical article of claim 5 which is fabricated from a hydrophilic polymer selected from the group consisting of natural rubber latex and biomedical polyurethane.
- 7. The medical article of claim 5 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
- 8. The medical article of claim 6 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
- 9. The medical article of claim 5 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
- 10. The medical article of claim 6 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
- 11. A hydrophobic polymeric medical article which has been impregnated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophobic polymer; between 1 and 5 percent of chlorhexidine, wherein the chlorhexidine consists essentially of a mixture of chlorhexidine free base and a chlorhexidine salt; and (iii) between 0.5 and 5 percent of triclosan.
- 12. The medical article of claim 11 which is fabricated from a hydrophobic polymer selected from the group consisting of polytetrafluoroethylene, Dacron, polyvinylchloride, biomedical silicone polymer, and silicone polyurethane copolymer.
- 13. The medical article of claim 11 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
- 14. The medical article of claim 12 wherein the hydrophobic polymer in the treatment solution is a biomedical silicone polymer.
- 15. The medical article of claim 11 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
- 16. The medical article of claim 12 wherein the hydrophobic polymer in the treatment solution is a silicone-polyurethane copolymer.
- 17. A hydrophobic polymeric medical article which has been impregnated with a treatment solution comprising (i) between about 1 and 10 percent of a hydrophilic polymer; (ii) between 1 and 5 percent of chlorhexidine, wherein the chlorhexidine consists essentially of a mixture of chlorhexidine free base and a chlorhexidine salt; and (iii) between 0.5 and 5 percent of triclosan.
- 18. The medical article of claim 17 which is fabricated from a hydrophobic polymer selected from the group consisting of polytetratluoroethylene, Dacron, polyvinylchloride, biomedical silicone polymer, and silicone polyurethane copolymer.
- 19. The medical article of claim 17 wherein the hydrophilic polymer is a biomedical polyurethane.
- 20. A method of preparing an infection resistant medical article comprising:(i) placing the medical article in an impregnating solution comprising (a) a solvent selected from the group consisting of water, reagent alcohol, tetrahydrofuran, and mixtures thereof; and (b) chlorhexidine and triclosan in a molar ratio of between 1:1 and 1:3, wherein the total weight of chlorhexidine and triclosan is between 1 and 10 percent of the weight of the impregnating solution and wherein the chlorhexidine consists essentially of a mixture of chlorhexidine free base and a chlorhexidine salt; (ii) soaking the medical article in the impregnating solution for a period of time sufficient to allow the medical article to swell and to incorporate the chlorhexidine and triclosan; (iii) removing the medical article from the impregnating solution; and (iv) drying the medical article.
- 21. The method of claim 20, wherein the solvent in step (1)(a) is a mixture of reagent alcohol and tetrahydrofuran.
- 22. The method of claim 20, wherein the ratio of chlorhexidine free base and triclosan in step (1)(b) is about 1:2.
- 23. The method of claim 20, wherein the total weight percent of chlorhexidine free base and triclosan in step (1)(b) is about 2-10.
- 24. The method of claim 20, which has further been coated with a coating solution comprising a biomedical polymer.
- 25. The method of claim 24, wherein the biomedical polymer in the coating solution comprises an antimicrobial agent.
- 26. The method of claim 20 which is fabricated from polyurethane.
- 27. The method of claim 26 which is a polyurethane catheter.
- 28. The method of claim 27 in which both the external and internal surfaces of the catheter are brought into contact with the impregnating solution.
- 29. The method of claim 27 in which only the external surface of the catheter is brought into contact with the impregnating solution.
- 30. The method of claim 27, in which only the internal surface of the catheter is brought into contact with the impregnating solution.
Parent Case Info
This application is a continuation of U.S. patent application Ser. No. 09/104,129, U.S. Pat. No. 6,105,505, filed Jun. 30, 1998, which is a national phase application pursuant to 35 U.S.C. §371 of PCT/US96/20932, filed Dec. 23, 1996, which is a continuation-in-part of U.S. patent application Ser. No. 08/583,239, filed Jan. 5, 1996, now issued as U.S. Pat. No. 5,772,640.
US Referenced Citations (20)
Foreign Referenced Citations (3)
Number |
Date |
Country |
9302717 |
Feb 1993 |
WO |
9306881 |
Apr 1993 |
WO |
9622114 |
Jul 1996 |
WO |
Non-Patent Literature Citations (1)
Entry |
Bach et al., 1994, “Prevention of bacterial colonization of intravenous catheters by antiseptic impregnation of polyurethane polymers,” Journal of Antimicrobial Chemotherapy, 33:969-978. |
Continuations (1)
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Number |
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Parent |
09/101129 |
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US |
Child |
09/618432 |
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US |
Continuation in Parts (1)
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Number |
Date |
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08/583239 |
Jan 1996 |
US |
Child |
09/101129 |
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US |