Claims
- 1. A compound of the formula ##STR25## wherein Q and R.sub.a are different and either a nitrogen atom or a =CR'"-function,
- R.degree. represents ##STR26## R' represents hydrogen, and R" represents hydrogen; lower alkyl of 1 to 5 carbon atoms; allyl; methylallyl; propargyl; cycloalkyl of 3 to 6 carbon atoms; or di(lower of 1 to 3 carbon atoms)alkylamino(lower of 1 to 4 carbon atoms)alkyl; or lower alkoxy of 1 to 4 carbon atoms (lower of 1 to 4 carbon atoms)alkyl; or
- R' and R" together with the nitrogen attached to the ring represent di(lower of 1 to 3 carbon atoms)alkylamino; diallylamino; di(methylallyl)amino; or dipropargylamino; or
- R' and R" together with the nitrogen attached to the tricyclic ring system form a 3 to 6 membered saturated heterocyclic group represented by: ##STR27## wherein X is (a) direct bond or (b) methylene, and y and z are 0 or 1, provided that X is a direct bond when either y or z is 0;
- R'" represents hydrogen or lower alkyl of 1 to 4 carbon atoms;
- R.sub.1 represents fluoro, chloro, bromo, lower alkyl of 1 to 3 carbon atoms, lower alkoxy of 1 to 3 carbon atoms, nitro, trifluoromethyl or, when n 2, the two R.sub.1 's together form methylenedioxy, and
- n is 0, 1, 2 or 3, and when 2, then R.sub.1 may be the same or different, and when 3, then all R.sub.1 's are alkoxy; provided that n is 1 when R.sub.1 is nitro or trifluoromethyl.
- 2. A compound of claim 1 having the formula: ##STR28## wherein R', R", R'", R.sub.1 and n are as defined in claim 1.
- 3. A compound of claim 2 in which R' and R" together with the nitrogen atom attached to the tricyclic ring system form ##STR29##
- 4. A compound of claim 3 in which each of y and z are 1.
- 5. A compound of claim 1 having the formula: ##STR30## wherein R.sub.1, n, R', R" and R'" are as defined in claim 1.
- 6. A compound of claim 5 in which R' and R" together with the nitrogen atom attached to the tricyclic ring system form ##STR31##
- 7. A compound of claim 6 in which each of y and z are 1.
- 8. A compound of claim 5 having the formula: ##STR32## in which q is 2 to 5.
- 9. A compound of claim 8 having the fomrula: ##STR33##
- 10. A compound of claim 9 in which (R.sub.1).sub.n - is 8,9-dimethoxy.
- 11. The compound of claim 10 in which R'" is hydrogen.
- 12. The compound of claim 10 in which R'" is methyl.
- 13. The compound of claim 10 in which R'" is ethyl.
- 14. The compound of claim 10 in which R'" is isopropyl.
- 15. A compound of claim 8 in which (R.sub.1).sub.n - is 8,9-dimethoxy.
- 16. The compound of claim 15 in which R'" is hydrogen and q is 3.
- 17. A compound of claim 9 in which R'" is methyl.
- 18. A compound of claim 5 in which R" is lower alkyl.
- 19. A compound of claim 18 in which (R.sub.1).sub.n - is 8,9-dimethoxy.
- 20. A compound of claim 1 having the formula ##STR34## wherein Q and R.sub.a are different and either a nitrogen atom or a =CR'"-function,
- R.degree. represents ##STR35## R' represents hydrogen, and R" represents hydrogen; lower alkyl of 1 to 5 carbon atoms; allyl; methylallyl; propargyl; cycloalkyl of 3 to 6 carbon atoms; or di(lower of 1 to 3 carbon atoms)alkylamino(lower of 1 to 4 carbon atoms)alkyl; or
- R' and R" together with the nitrogen attached to the ring represent di(lower of 1 to 3 carbon atoms) alkylamino; diallylamino; di(methylallyl)amino; or dipropargylamino; or
- R' and R" together with the nitrogen attached to the tricyclic ring system form a 3 to 6 membered saturated heterocyclic group represented by: ##STR36## wherein X is (a) a direct bond or (b) methylene, and y and z are 0 or 1, provided that X is a direct bond when either y or z is 0;
- R'" represents hydrogen or lower alkyl of 1 to 4 carbon atoms;
- R.sub.1 represents fluoro, chloro, bromo, lower alkyl of 1 to 3 carbon atoms, lower alkoxy of 1 to 3 carbon atoms, nitro, trifluoromethyl or, when n is 2, the two R.sub.1 's together form methylenedioxy, and
- n is 0, 1, 2 or 3, and when 2, then R.sub.1 may be the same or different, and when 3, then all R.sub.1 's are alkoxy; provided that n is 1 when R.sub.1 is nitro or trifluoromethyl.
- 21. The compound of claim 2 which is 5-cyclobutylamino-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline.
- 22. The compound of claim 2 which is 5-cyclohexylamino-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline.
- 23. The compound of claim 2 which is 5-cyclopentylamino-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline.
- 24. The compound of claim 2 which is 5-cyclopropylamino-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline.
- 25. The compound of claim 2 which is 5-cyclopropylamino-3-methyl-8,9-dimethoxy-1,2,4-triazolo[4,3-c]quinazoline
- 26. The compound of claim 2 which is 5-cyclopropylamino-3-ethyl-8,9-dimetoxy-1,2,4-triazolo[4,3-c]quinazoline.
- 27. A pharmaceutical composition for treating inflammation in mammals comprising an inert pharmaceutically acceptable carrier and an anti-inflammatory effective amount of a compound of claim 20.
- 28. A method of treating inflammation in mammals comprising administering to a mammal in need of such treatment an anti-inflammatory effective amount of a compound of claim 1.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 339,177, filed Mar. 8, 1973, which in turn is a continuation-in-part of application Ser. No. 209,425, filed Dec. 17, 1971, which in turn is a continuation-in-part of application Ser. No. 72,799, filed Sept. 16, 1970, all of which are now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3838126 |
Wagner |
Sep 1974 |
|
Continuation in Parts (3)
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Number |
Date |
Country |
Parent |
339177 |
Mar 1973 |
|
Parent |
209425 |
Dec 1971 |
|
Parent |
72799 |
Sep 1970 |
|