Claims
- 1. A tricyclic compound represented by formula (I): ##STR13## where X.sup.1 -X.sup.2 represents CH.dbd.CH--CH.dbd.CH
- Y--Z represents CH.sub.2 --O or CH.sub.2 --S;
- L--M represents C.dbd.CR.sup.9 (in which R.sup.9 represents hydrogen or lower alkyl) or CH--CR.sup.10 R.sup.11 (in which each of R.sup.10 and R.sup.11 independently represents hydrogen or lower alkyl);
- W represents NR4 (in which R4 represents hydrogen or lower alkyl) or O,
- each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen, lower alkyl, lower alkoxy, halogen, nitro, amino or mono- or di-lower alkyl-substituted amino;
- R.sup.5 represents hydrogen or lower alkyl;
- each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, halogen, lower alkyl or lower alkoxy;
- and a pharmaceutically acceptable salt thereto.
- 2. The compound according to claim 1, wherein Y--Z is CH.sub.2 --O, L--M is CH--CH.sub.2 and W is NH.
- 3. The compound according to claim 2, wherein R.sup.5 is hydrogen, one of R.sup.6, R.sup.7 and R.sup.8 is 2-isopropyl, one of the remaining two is 6-isopropyl and the other is hydrogen.
- 4. N-(2,6-Diisopropylphenyl)-N'-(2-bromo-6,11-dihydrodibenz�b,e!oxepin-11-ylmethyl)urea or a pharmaceutically acceptable salt thereof.
- 5. N-(2,6-Diisopropylphenyl)-N'-(2-bromo-4-dimethylamino-6,11-dihydrodibenz�b,e!oxepin-11-ylmethyl)urea or a pharmaceutically acceptable salt thereof.
- 6. A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and as the active ingredient, an effective amount of the compound as defined by claim 1.
- 7. The compound according to claim 3, wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen.
Priority Claims (1)
Number |
Date |
Country |
Kind |
4-246845 |
Sep 1992 |
JPX |
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CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation application of application Ser. No. 214,535, filed Mar. 18, 1994 (now abandoned), which application is a continuation-in-part application of application Ser. No. 121,648, filed Sep. 16, 1993 (now abandoned).
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4868210 |
Trivedi et al. |
Sep 1989 |
|
4882351 |
Oshima et al. |
Nov 1989 |
|
5340807 |
Kumazawa et al. |
Aug 1994 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
214535 |
Mar 1994 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
121648 |
Sep 1993 |
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