TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE

Abstract

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.

Description

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 presents non-limiting examples of compounds described herein.

FIG. 2 presents non-limiting examples of compounds described herein.

FIG. 3 presents non-limiting examples of compounds described herein.

FIG. 4 presents non-limiting examples of compounds described herein.

FIG. 5 presents non-limiting examples of compounds described herein.

FIG. 6 present an illustrative scheme for the treatment of patients using the compounds and methods described herein.

FIG. 7 present an illustrative scheme for the treatment of patients using the compounds and methods described herein.

FIG. 8 present an illustrative scheme for the treatment of patients using the compounds and methods described herein.

Claims

1. A compound having a structure represented by Formula (IIIc):

2. The compound of claim 1, wherein: R9 is H, halide, —CN, —NO2, —OH, or an optionally substituted group selected from among C1-C6alkyl, C1-C6fluoroalkyl, and C1-C6alkoxy.

3. The compound of claim 2, wherein: L1 is selected from among —(CHR4)n—, —(CHR4)nO—, —(CHR4)nS—, —O(CHR4)n—, and —S(CHR4)n—; each R4 is independently H, or an optionally substituted group selected from among C1-C6alkyl, and C1-C6fluoroalkyl;n is 0, 1, or 2.

4. The compound of claim 3, wherein: each R4 is H;n is 0 or 1.

5. The compound of claim 4, wherein: R13 is H, C1-C6alkyl, —OH, C1-C6alkoxy, —CN, halide, or C1-C6haloalkyl;R4 is H, C1-C6alkyl, —OH, C1-C6alkoxy, —CN, halide, or C1-C6haloalkyl; orR8 and R14 taken together can form an optionally substituted 5-, or 6-membered ring

6. The compound of claim 5, wherein: each R1 is independently H, halide, —CN, —NO2, —OH, —OR3, —SR3, —S(═O)R3, —S(═O)2R3, —C(═O)R3, —C(═O)OR3, —CH(R3)2, —N(R3)2, —NHCH2C(═O)OR3, —C(═O)N(R3)2, —NHC(═O)R3, or —C(OH)(R3)2, or an optionally substituted group selected from among C1-C6alkyl, C1-C6fluoroalkyl, C3-C8cycloalkyl, C2-C6alkenyl, C2-C6alkynyl, and C1-C6fluoroalkoxy; orR1 is Q1-Q2 where Q1 is aryl, monocyclic heterocycloalkyl, monocyclic heteroaryl; and Q2 is H, halide, —CN, —NO2, C1-C6alkyl, C1-C6alkoxy, —OR3, —SR3, —S(═O)R3, —S(═O)2R3, —C(═O)R3, —C(═O)OR3, —CH(R3)2, —N(R3)2, or —C(═O)N(R3)2.

7. The compound of claim 6, wherein: R6 and R7 are independently H, or an optionally substituted group selected from among C1-C6haloalkyl, C1-C6alkyl, C3-C8cycloalkyl, C2-C6alkenyl, C2-C6alkynyl, thiazolyl, C1-C6alkoxy, C1-C6thioalkoxy, and C1-C6alkyl-X4, wherein, X4 is —CO2H, —CO2R11, C1-C6alkoxy, tetrazolyl, —OH, —CON(R11)2, where each R11 is independently H, or an optionally substituted group selected from among C1-C6alkyl, and C1-C6fluoroalkyl; orR6 and R7 can together form an optionally substituted 5-, 6-, or 7-membered monocyclic ring containing 0, 1, or 2 heteroatoms selected from among S and O; orR6 and R7 can together form a carbonyl (C═O).

8. The compound of claim 7, wherein: R6 and R7 are independently H, or an optionally substituted group selected from among C1-C6haloalkyl, C1-C6alkyl, C3-C8cycloalkyl, C2-C6alkenyl, and C1-C6alkyl-X4, wherein, X4 is —CO2H, —CO2R11, or —CON(R11)2, where each R11 is independently H, or an optionally substituted C1-C6alkyl; orR6 and R7 can together form an optionally substituted 6-membered monocyclic ring containing 0 or 1 O atoms; orR6 and R7 can together form a carbonyl (C═O).

9. The compound of claim 8, wherein: R8 is H, —OH, —CONH2, tetrazolyl, —CN, C1-C6alkyl, C2-C6alkenyl, —CF3, —CO2H, —OR12, —CON(R12)2, —CO2—R12, —SR12, —S(═O)R12, S(═O)2R12, —SO2N(R12)2, C(═O)R12, C(OH)(R12)2, —CH═N—OR2, or —OC(═O)R12; where each R12 is independently H, or an optionally substituted group selected from among C1-C6alkyl, C1-C6fluoroalkyl, C3-C8cycloalkyl, C4-C8cycloalkylalkyl, phenyl, and benzyl.

10. The compound of claim 9, wherein: G4 is CR1.

11. The compound of claim 9, wherein: G4 is N.

12. The compound of claim 11, wherein: G1 is CR1.

13. The compound of claim 11, wherein: G1 is N.

14. The compound of claim 9, wherein the compound has a structure of Formula (V):

15. The compound of claim 14, wherein: G1 is CR1.

16. The compound of claim 14, wherein: G1 is N.

17. A compound selected from among: 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-benzyloxy]-imidazo[1,2-a]quinoline (Compound 1-1); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-imidazo[1,2-a]quinoline (Compound 1-2); 4-[3-Fluoro-5-(imidazo[1,2-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-3); 4-[3-Fluoro-5-(imidazo[1,2-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 1-4); 4-[3-Fluoro-5-(imidazo[1,2-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-5); 4-[3-Fluoro-5-(imidazo[1,2-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-6); 4-[3-(1-Bromo-imidazo[1,2-a]quinolin-7-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-7); 4-[3-Fluoro-5-(1-phenyl-imidazo[1,2-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-8); 4-[3-(Imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-9); 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoline (Compound 1-10); 4-[3-(Imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-11); 4-[3-(2-Methyl-imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-12); 4-[3-(Imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-13); 4-[3-(1-Methyl-imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-14); 4-{3-[1-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 1-15); 4-[3-Fluoro-5-(imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-16); 4-[3-(1-Bromo-imidazo[1,2-a]quinolin-7-ylsulfanyl)-5-fluoro-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-17); 4-[3-Fluoro-5-(1-phenyl-imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-18); 4-[3-Fluoro-5-(2-phenyl-imidazo[1,2-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-19); 7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-5-fluoro-phenylsulfanyl]-imidazo[1,2-a]quinoline-2-carboxylic acid ethyl ester (Compound 1-20); 7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-5-fluoro-phenylsulfanyl]-imidazo[1,2-a]quinoline-2-carboxylic acid (Compound 1-21); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoxaline (Compound 1-24); 8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-imidazo[1,2-a]quinoline (Compound 1-25); 4-[3-(5-Chloro-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-26); 4-[3-(5-Chloro-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-27); 4-[3-Fluoro-5-(5-methylsulfanyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 1-28); 4-[3-Fluoro-5-(5-methylsulfanyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-29); 4-[3-Fluoro-5-(5-phenyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-30); 4-[3-(5-Cyclopentylsulfanyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 1-31); 4-[3-(5-Cyclopentylsulfanyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-32); 4-[3-(5-Bromo-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-33); 4-[3-(5-Bromo-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 1-34); 4-[3-(5-Bromo-imidazo[1,2-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-35); 4-[3-Fluoro-5-(5-phenyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-36); 4-[3-Fluoro-5-(5-pyridin-3-yl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-37); 4-{3-Fluoro-5-[5-(3-methoxy-phenyl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-38); 4-{3-Fluoro-5-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-39); 4-{3-Fluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-40); 4-[3-Fluoro-5-(5-pyridin-4-yl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-41); 4-[3-Fluoro-5-(5-m-tolyl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-42); 4-{3-[5-(4-Amino-phenyl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-5-fluoro-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-43); 4-{3-Fluoro-5-[5-(4-fluoro-phenyl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-44); 4-{3-Fluoro-5-[5-(2-methoxy-phenyl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-45); 4-{3-Fluoro-5-[5-(4-methoxy-phenyl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-46); 4-[3-Fluoro-5-(5-pyrimidin-5-yl-imidazo[1,2-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-47); 4-{3-Fluoro-5-[5-(4-methoxy-pyridin-3-yl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-48); 4-{3-Fluoro-5-[5-(6-methoxy-pyridin-3-yl)-imidazo[1,2-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-49); 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-50); 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-51); 5-Chloro-8-[3-(4-cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoline-2-carboxylic acid ethyl ester (Compound 1-52); 5-Chloro-8-[3-(4-cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoline-2-carboxylic acid (Compound 1-53); 5-Chloro-8-[3-(4-cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoline-2-carboxylic acid amide (Compound 1-54); 4-[3-(2-Chloro-5-phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-55); 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-56); 4-[3-(5-Methyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-57); 4-[3-(2-Chloro-5-phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-58); 4-[3-(5-Isopropyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-59); 4-[3-(5-Isopropyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-60); 8-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinoline-2-carboxylic acid ethyl ester (Compound 1-61); 8-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinoline-2-carboxylic acid (Compound 1-62); 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 1-63); 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 1-64); 4-[3-(2-Chloro-5-isopropyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-65); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-isopropyl-imidazo[1,2-a]quinoline-2-carboxylic acid (Compound 1-66); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinoline-2-carboxylic acid (Compound 1-67); 4-[3-(5-Methyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-68); 4-[3-(5-Isopropyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-69); 5-Chloro-8-[3-(4-cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoline-2-carbonitrile (Compound 1-70); 4-[3-(2-Chloro-5-isopropyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-71); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-isopropyl-imidazo[1,2-a]quinoline-2-carbonitrile (Compound 1-72); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinoline-2-carbonitrile (Compound 1-73); 4-[3-(2-Chloro-5-isopropyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-74); 4-[3-(2-Hydroxymethyl-5-phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-75); 4-{3-[2-(1-Hydroxy-1-methyl-ethyl)-5-phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-ol (Compound 1-76); 4-[3-(2-Hydroxymethyl-5-methyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-77); 4-{3-[2-(1-Hydroxy-1-methyl-ethyl)-5-methyl-imidazo[1,2-a]quinolin-8-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-ol (Compound 1-78); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-methyl-imidazo[1,2-a]quinoline-2-carboxylic acid (Compound 1-79); 4-[3-(2-Fluoromethyl-5-phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-80); Succinic acid mono-{8-[3-(4-hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinolin-2-ylmethyl}ester (Compound 1-81); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinoline-2-carboxylic acid ethyl ester (Compound 1-82); 1-{8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinolin-2-yl}-ethanone (Compound 1-83); 8-[3-(4-Hydroxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-5-phenyl-imidazo[1,2-a]quinoline-2-carbaldehyde (Compound 1-84); 4-[3-(5-Chloro-imidazo[1,2-a]quinolin-8-ylsulfanyl)-5-fluoro-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-85); 4-[3-(Imidazo[1,2-a]quinoxalin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 1-86); 4-[3-(Imidazo[1,2-a]quinoxalin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 1-87); 4-[3-(Imidazo[1,2-a]quinoxalin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 1-88); 8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-imidazo[1,2-a]quinoxaline (Compound 1-89); 4-[3-(Imidazo[1,2-a]quinoxalin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbaldehyde O-methyl-oxime (Compound 1-90); 6-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-1); 5-Chloro-6-[3-fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-2); 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-3); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-4); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-5); 4-[3-Fluoro-5-([1,2,4]triazolo[4,3-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid ethyl ester (Compound 5-6); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-thiazol-2-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-7); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-5-furan-3-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-8); 5-Bromo-7-[3-fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-9); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-phenyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-10); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-methyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-11); 4-[3-Fluoro-5-([1,2,4]triazolo[4,3-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-12); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-quinolin-2-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-13); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-14); 4-[3-Fluoro-5-([1,2,4]triazolo[4,3-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 5-15); 4-[3-Fluoro-5-([1,2,4]triazolo[4,3-a]quinolin-7-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-16); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-17); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline-1-carboxylic acid ethyl ester (Compound 5-18); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinolin-1-ylamine (Compound 5-19); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoxaline (Compound 5-20); 4-[3-([1,2,4]Triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-21); 4-[3-([1,2,4]Triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-22); 4-[3-(1-Thiazol-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-23); 4-[3-(1-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-24); 4-[3-(1-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-25); 4-[3-(1-Thiazol-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-26); 4-[3-(1-Methyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-27); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-28); 4-[3-(1-Pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-29); 4-[3-(1-Pyridin-4-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-30); 4-{3-[1-(1H-Imidazol-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-31); 4-{3-[1-(4-Fluoro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-32); 3-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-benzoic acid (Compound 5-33); 4-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-benzoic acid (Compound 5-34); 4-{3-[1-(4-Methoxy-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-35); 4-[3-(1-Trifluoromethyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-36); 4-{3-[1-(2-Fluoro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-37); 4-{3-[1-(3-Fluoro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-38); 4-[3-(1-Cyclohexyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-39); 4-[3-(1-Ethyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-40); 4-[3-(1-Isopropyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-41); 4-[3-(1-Isobutyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-42); 2-Methyl-4-[3-(1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-43); 4-[3-(1-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-44); 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-phenyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-45); 7-[3-(4-Cyclopropylmethoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-phenyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-46); 4-[3-(1-Cyclopentyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-47); 4-[3-(1-Cyclopropyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-48); 4-{3-[1-(1-Methyl-1H-imidazol-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-49); 4-[3-(1-Pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-50); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-51); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-52); (2S,4R)-2-Methyl-4-[3-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-53); 4-[3-(1-Pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-54); 4-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-benzamide (Compound 5-55); {7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-ylmethyl}-carbamic acid tert-butyl ester (Compound 5-56); (2-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-ethyl)-carbamic acid benzyl ester (Compound 5-57); (S)-2-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester (Compound 5-58); (R)-2-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester (Compound 5-59); 3-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-propionic acid (Compound 5-60); 4-[3-(1-Aminomethyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-61); 4-[3-((S)-1-Pyrrolidin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-62); 4-[3-((R)-1-Pyrrolidin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-63); 4-{3-[1-(6-Methoxy-pyridin-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-64); N-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-ylmethyl}-acetamide (Compound 5-65); 4-[3-(1-Dimethylaminomethyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-66); 4-{3-[1-((S)-1-Methyl-pyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-67); 4-{3-[1-((R)-1-Methyl-pyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-68); 4-{3-[1-((S)-1-Acetyl-pyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-69); 4-{3-[1-((R)-1-Acetyl-pyrrolidin-2-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-70); 5-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-pentanoic acid methyl ester (Compound 5-71); 4-{3-[1-(6-Methoxy-pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-72); 4-{3-[1-(3-Methoxy-pyridin-4-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-73); 4-{3-[1-(5-Methoxy-pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}tetrahydro-pyran-4-carbonitrile (Compound 5-74); 5-{7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinolin-1-yl}-pentanoic acid (Compound 5-75); 2-Methyl-4-[3-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-76); 7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline-4-carboxylic acid methyl ester (Compound 5-77); 2-Methyl-4-[3-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-78); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbaldehyde O-methyl-oxime (Compound 5-79); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-80); {4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-yl}-methanol (Compound 5-81); 1-{4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-yl}-ethanol (Compound 5-82); 7-[3-(4-Methanesulfonyl-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-83); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-sulfonic acid dimethylamide (Compound 5-84); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 5-85); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid methylamide (Compound 5-86); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid (2-hydroxy-ethyl)-amide (Compound 5-87); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid dimethylamide (Compound 5-88); 1-{4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-yl}-ethanone (Compound 5-89); 2-{4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-yl}-propan-2-ol (Compound 5-90); 1-Pyridin-2-yl-7-[3-(4-vinyl-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-91); 7-[3-(4-Ethyl-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-92); 4-[3-Fluoro-5-(1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-93); 4-{3-Fluoro-5-[1-(1-hydroxy-1-methyl-ethyl)-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-94); 4-[3-Fluoro-5-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-95); 4-[3-Fluoro-5-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-96); 4-[3-Fluoro-5-([1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-97); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-98); 4-[3-(1-Phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-103); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-104); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-105); (2S,4R)-2-Methyl-4-[3-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-106); 4-[3-(1-Pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-107); 4-[3-(1-Pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-108); {7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-ylamino}-acetic acid methyl ester (Compound 5-109); {7-[3-(4-Cyano-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-ylamino}-acetic acid (Compound 5-110); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-111); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbaldehyde O-methyl-oxime (Compound 5-112); 1-{4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-yl}-ethanone (Compound 5-113); 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-4,6-dimethyl-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxaline (Compound 5-114); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbaldehyde oxime (Compound 5-115); 4-[3-Fluoro-5-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxalin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-116); 7-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoxaline (Compound 5-117); 4-[3-(1-Phenyl-[1,2,4]triazolo[4,3-a]quinoline-7-sulfinyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-118); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline-7-sulfinyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-119); 4-[3-(1-Phenyl-[1,2,4]triazolo[4,3-a]quinoline-7-sulfonyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-120); 4-[3-(1-Pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinoline-7-sulfonyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-121); 8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-122); 5-Bromo-8-[3-fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-123); 8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-5-furan-3-yl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-124); 5-Chloro-8-[3-fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-125); 8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 5-126); 3-{8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-[1,2,4]triazolo[4,3-a]quinolin-5-yl}-benzoic acid (Compound 5-127); 4-[3-(5-Chloro-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-128); 4-[3-Fluoro-5-(5-methylsulfanyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-129); 4-[3-Fluoro-5-(5-methoxy-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-130); 4-[3-Fluoro-5-([1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-131); 4-[3-Fluoro-5-(5-pyridin-3-yl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-132); 4-[3-Fluoro-5-(5-pyridin-4-yl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-133); 4-[3-Fluoro-5-(5-thiophen-3-yl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-134); 4-{3-[5-(3-Cyano-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy]-5-fluoro-phenyl}-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-135); 4-{3-Fluoro-5-[5-(3-methoxy-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-136); 4-[3-Fluoro-5-(5-m-tolyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-137); 4-[3-Fluoro-5-(5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-138); 4-[3-(5-Chloro-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-5-fluoro-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-139); 4-{3-Fluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-140); 4-[3-Fluoro-5-(5-m-tolyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-141); 4-{3-Fluoro-5-[5-(4-fluoro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-8-ylmethoxy]-phenyl}-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-142); 4-[3-(1-Thiazol-2-yl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-143); 4-[3-([1,2,4]Triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-144); 4-[3-(5-Chloro-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]tetrahydro-pyran-4-carbonitrile (Compound 5-145); 4-[3-(5-m-Tolyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-146); 4-{3-[5-(1-Methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-147); 4-{3-[5-(4-Fluoro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl]-phenyl}-tetrahydro-pyran-4-carbonitrile (Compound 5-148); 4-[3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-149); 4-[3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-150); 4-[3-(5-Methyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-151); 4-[3-(1-Methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-153); 4-[3-(1-Methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-154); 4-[3-(1-Amino-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol (Compound 5-155); 4-[3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid amide (Compound 5-156); 4-[3-(5-Phenyl-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-157); 4-[3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid (Compound 5-158); 4-[3-(5-Chloro-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-5-fluoro-phenyl]-tetrahydro-pyran-4-carbonitrile (Compound 5-159); 8-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-[1,2,4]triazolo[4,3-a]quinoxaline (Compound 5-160); 4-[2-Methoxy-5-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carboxylic acid methyl ester (Compound 5-161); 3-spiro-(4′-Tetrahydropyran)-5-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-3H-benzofuran-2-one (Compound 5-162); Dicyclopropyl-[3-(1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-methanol (Compound 10-11); Dicyclopropyl-[3-(1-pyridin-2-yl-[1,2,4]triazolo[4,3-a]quinolin-7-ylsulfanyl)-phenyl]-methanol (Compound 10-12); 4,4,4-Trifluoro-3-hydroxy-3-[2-([1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-thiazol-5-yl]-butyric acid (Compound 10-13); 1-[3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-cyclohexanol (Compound 10-17); 3-[3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-pentan-3-ol (Compound 10-18); 3-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-pentan-3-ol (Compound 10-19); 3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-benzoic acid (Compound 11-8); 3-(5-Phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-benzamide (Compound 11-9); N-Methyl-3-(5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-benzamide (Compound 11-10); N,N-Dimethyl-3-(5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-benzamide (Compound 11-11); N-(2-Hydroxy-ethyl)-3-(5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-benzamide (Compound 11-12); Morpholin-4-yl-[3-(5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-8-ylsulfanyl)-phenyl]-methanone (Compound 11-13); 8-(3-Cyclopent-1-enyl-phenylsulfanyl)-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline (Compound 11-14).

18. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable excipient.

19. A method for treating inflammation in a mammal comprising administering a therapeutically effective amount of a compound of claim 1 to the mammal in need.

20. A method for treating respiratory disease in a mammal comprising administering a therapeutically effective amount of a compound of claim 1 to the mammal in need.

21. The method of claim 20, wherein the respiratory disease is asthma.

22. A method for treating cardiovascular disease in a mammal comprising administering a therapeutically effective amount of a compound of claim 1 to the mammal in need.