Tricyclic-substituted piperidine antihistamines

Abstract

Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is defined hereinbelow.

Description

The present invention relates to novel antihistamines.

The compounds of the present invention may be similar in structure to known antihistamines (for example, azatadine, disclosed in U.S. Pat. No. 3,326,924) but are preferred to the starting materials because the present compounds have little or no sedative effects, thus being preferred for use with patients that must operate machinery or automobiles or perform other mental or physical tasks requiring a high level of concentration.

The present invention also relates to a method of reducing and/or eliminating the sedating effects of antihistamines (for example, dialkylaminoalkyl ethers, dialkylaminoalkyl amines and dialkylaminoethylene diamines), by replacing one of the lower alkyl groups on a tertiary amine by a non-basic function, for example, a carboalkoxy or an alkylsulfonyl derivative.

The compounds of the present invention are compounds of the formula ##STR6## wherein ##STR7## is a 5 or 6 membered ring which is phenyl or heterocyclic (for example, 2- or 3-thiophene or 2-, 3-, or 4-pyridyl); ##STR8## is a six membered ring which is 2-, 3-, or 4-pyridyl or is phenyl or substituted phenyl (for example, phenyl substituted with halo), with the proviso that if ##STR9## is a nitrogen containing ring, ##STR10## must be phenyl or substituted phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR11## wherein p is 1 or 2 and n is 1 or 2; R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.3 alkyl, and the dotted line represents an optional double bond, R.sup.2 being absent if the double bond is present, and Y is substituted carboxylate or substituted sulfonyl. Preferably, Y is --COOR or --SO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, more preferably C.sub.2 to C.sub.6 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, more preferably substituted C.sub.2 to C.sub.6 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl or C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl, and with the proviso that when Y is -SO.sub.2 R, R is C.sub.1 to C.sub.12 alkyl, C.sub. 2 to C.sub.12 alkenyl, more preferably C.sub.2 to C.sub.6 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.

Preferably, when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl or substituted alkyl, more preferably, R is C.sub.1 to C.sub.6 alkyl or substituted alkyl, and most preferably R is C.sub.1 to C.sub.6 alkyl.

Preferably, when Y is --SO.sub.2 R, R is C.sub.1 to C.sub.12 alkyl, more preferably C.sub.1 to C.sub.6 alkyl.

In a preferred embodiment, the compounds of the present invention are compounds of the formula ##STR12## wherein the dotted line represents an optional double bond and wherein the numbering system used herein for these preferred compounds is illustrated. In this formula, X is hydrogen or halo and Y is substituted carboxylate or substituted sulfonyl. Preferably, Y is --COOR or --SO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, more preferably C.sub.2 to C.sub.6 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, more preferably substituted C.sub.2 to C.sub.6 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl or C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl; and with the proviso that when Y is --SO.sub.2 R, R is C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, more preferably C.sub.2 to C.sub.6 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.

Preferably, when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl or substituted alkyl, more preferably, R is C.sub.1 to C.sub.6 alkyl or substituted alkyl, and most preferably R is C.sub.1 to C.sub.6 alkyl.

Preferably, when Y is --SO.sub.2 R, R is C.sub.1 to C.sub.12 alkyl, more preferably C.sub.1 to C.sub.6 alkyl.

The aforementioned alkyl groups in formula I and formula II may be linear, branched or cyclic or may contain both cyclic and linear or cyclic and branched moieties. Halo may be fluoro, chloro, bromo or iodo.

The present invention also relates to a pharmaceutical composition comprising an effective amount of a compound of the formula I as defined above, together with a pharmaceutically acceptable carrier and to a method of effecting an anti-allergic response in an animal comprising administering to the animal an effective amount of the formula I as defined above.

Generally, compounds of the present invention are prepared by replacing a methyl or another replacable substituent, for example carbophenoxy, on the nitrogen of an appropriate compound of the formula I with the desired substituent.

For example, compounds of the formula I wherein Y is --COOR are prepared by reacting a compound of the formula I wherein Y is methyl (Compound IA) or an appropriate derivative of Compound IA with an appropriate chloroformate, for example, an alkylchloroformate or phenyl chloroformate, in order to replace the N-methyl group of Compound IA.

Compounds of the formula I wherein Y is --COOR may also be prepared by reacting a compound of the formula I wherein Y is --COOR and R is phenyl with the sodium salt of an appropriate alcohol.

Compounds of the formula I wherein Y is --COOR may also be prepared by reacting a compound of the formula I wherein Y is --COOR and R is phenyl with the sodium salt of an appropriate alcohol.

Compounds of the formula I wherein Y is --COOR and R is tert-butyl may be prepared by reacting a compound of the formula I wherein Y is hydrogen with a di-tertiarybutyl carbonate in an inert solvent, for example, tetrahydrofuran.

Compounds of the formula I wherein Y is --SO.sub.2 R are prepared by reacting a compound of the formula I wherein Y is hydrogen with a compound of the formula Cl-SO.sub.2 R, wherein R has the same value as R in the desired product, in the presence of an excess of anhydrous potassium carbonate in an inert solvent, for example dry toluene.

It is also contemplated that compounds containing an asymetric center (for example, position 11 in formula II) may be resolved into their optical isomers (d and l) by methods well-known in the art.

The following non-limiting Examples further illustrate the preparation of the compounds of the present invention:

EXAMPLE 1

A. 11-(N-Carboethoxy-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

To a solution of 10.9 g (0.1 mole) of ethylchloroformate in 300 ml of anhydrous benzene is added dropwise, with stirring at room temperature, a solution of 14.5 g (0.05M) of 11-(N-methyl-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta[1,2-b]-pyridine (hereinafter referred to as Compound IA) in 200 ml of benzene. The solution is stirred and is heated under reflux overnight (16-20 hrs.). The mixture is cooled and is poured into ice water and the organic layer is separated, washed with water, dried, and then concentrated to dryness. The residue is triturated with petroleum ether and a white solid having a melting point of 106.degree.-107.degree. C. is recrystallized from isopropyl ether after decolorization with decolorizing carbon.

B. 11-(N-Carboethoxy-4-piperidylidene)-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

Using the procedure of Example IA, react 16.2 g of the 8-chloro derivative of Compound IA and 10.9 g (0.1 mole) of ethylchloroformate to prepare the title compound, having a melting point of 128.degree.-130.degree. C. The 7,9 and 10-chloro analogues are similarly prepared.

C. 11-(N-Carbomethoxy-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

Using the procedure of Example IA, react 14.5 g of Compound IA and 9.4 g of methylchloroformate to prepare the title compound, having a melting point of 116.degree.-118.degree. C.

D. 11-(.beta.-N-Methyl-N-carboethoxy)ethyl-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

Using the procedure of Example IA react a solution of 15.1 g (0.05 mole) of 11-(-dimethylaminoethyl)-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine in 300 ml anhydrous benzene with 10.9 g of ethylchloroformate at room temperature to prepare the title compound.

E. 11-(.beta.-N-Methyl-N-carbethoxy)ethylidene-6,11-dihydro-[5H]-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

Prepare the title compound by the procedure of Example IA using 14.9 g of dimethylamino ethylidine-6,11-dihydro-[5H]-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine and 10.9 of ethylchloroformate at room temperature in benzene.

F. 4-(N-Carboethoxy-piperidylidene)4H-benzo[4,5]-cyclohepta[1,2-b]-thiophene-10(9H)-one

Using the procedure of Example IA, react 21.3 g of N-methylpiperidylidene-4H-benzo-[4,5]-cyclohepta-[1,2-b]-thiophene-10(9H)-one in 300 ml of benzene with a solution of 10.9 g of ethylchloroformate in 300 ml benzene to prepare the title compound.

EXAMPLE 2

11-(N-Carbophenoxy-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine (Compound IB)

To a solution of 29.1 g (0.1 mole) of Compound IA in 150 ml of anhydrous carbon tetrachloride is added 17 g of phenylchloroformate in an equal volume of anhydrous carbontetrachloride. Heat under reflux for 15 minutes with stirring and pour into water. Separate and wash the organic layer with water and remove solvent. Extract the residue with ether, filter off the insoluble material and remove the ether. The residue is recrystallized from isopropyl ether to yield the title compound having a melting point of 127.degree.-130.degree. C. Similarly, prepare the 7,8,9, or 10-chloro derivatives of the title compound using this procedure.

EXAMPLE 3

11-(N-Carboisopropoxy-4-piperidylidene-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]pyridine

Dissolve 0.5 g of sodium metal in 50 ml isopropanol and add 7.9 g of Compound IB from Example 2. Heat with stirring for 5 hours on the steam bath at 90.degree.-95.degree. and allow to cool overnight.

Add ice water to precipitate the product and extract 3 times with ether and once with chloroform. Wash with water, distill off solvents, triturate with hexane and recrystallize from isopropylether. The melting point is 147.degree.-148.degree. C.

Using this procedure, and replacing the isopropanol with n-butanol, cyclopentanol, allyl alcohol, cyclopropylmethanol, benzylalcohol, p-chlorobenzylalcohol, phenethylalcohol, dimethylaminoethylalcohol or N-methyl-4-hydroxy piperidine prepare the corresponding carbamoyl derivatives. Similarly, using the chloro derivatives of Compound IB and the sodium salts of the aforementioned alcohols, prepare the chloro derivatives of the aforementioned carbamoyl derivatives.

EXAMPLE 4

11-(N-Carbo-t-butoxy-4-piperidylidene-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

Dissolve 13.8 g of 11-(4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine (Compound IC), prepared according to the method of Villani et. al., J. Med. Chem. 15, 750 (1972), in 250 ml of dry tetrahydrofuran. With stirring, add in one portion 12 g of di-butyl carbonate and stir at room temperature overnight. The mixture is poured into water, is extracted with ether and is washed with water and the solvent is removed. Recrystallize the residue from isopropyl ether. The melting point is 144.degree.-145.degree. C.

EXAMPLE 5

N-Methanesulfonyl-4-piperidylidene-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine

To 10 g of Compound IC in 200 ml of dry toluene add 13 g of anhydrous potassium carbonate. After several minutes of stirring at room temperature, add dropwise a solution of 6 g of methanesulfonyl chloride in 20 ml of toluene. Continue stirring for 16 to 20 hours and then filter. Recrystallize the solid material from ethanol. The melting point is 223.degree.-224.degree. C.

Using this procedure and adjusting the weight of the requisite sulfonyl chloride so that 0.04 moles of said alkanesulfonyl chloride are used, the ethanesulfonyl, n-propylsulfonyl, n-butylsulfonyl, cyclopropylsulfonyl, heptylsulfonyl, dodecylsulfonyl, phenylsulfonyl, p-methylphenyl-sulfonyl, p-fluorophenylsulfonyl, p-chlorophenylsulfonyl, benzylsulfonyl, p-chlorobenzylsulfonyl, p-tertbutylphenylsulfonyl and cyclopentylsulfonyl compounds of formula I wherein Y is SO.sub.2 R are obtained.

Similarly, prepare the tricyclic ring substituted chloro derivatives.

Substituting the appropriate starting material having a double bond between the 5 and 6 positions of the ring system, and using the procedures set forth in Examples 1 to 5 above (which show the preparation of the 6,11-dihydro compounds), the corresponding 6,11-dehydro compounds are prepared.

Also, by substituting an appropriate bromo or other halo analogue for the chloro substituted starting material mentioned above, other desired halo compounds of the Formula I may be prepared.

The compounds of the present invention are useful as non-sedating antihistamines. These compounds act as anti-allergic agents in the treatment of such conditions as perennial and seasonal allergic rhinitis and chronic urticaria.

The compounds of the present invention are administered in pharmaceutical formulations comprising the compound in admixture with a pharmaceutical carrier suitable for enteral or parenteral administration. The formulations may be in solid form, as for example tablets and capsules, or in liquid form as for example syrups, elixirs, emulsions, and injectables. In the formulation of pharmaceutical dosage forms there generally is utilized excipients, for example, water gelatin, lactose, starches, magnesium stearate, talc, vegetable oils, benzyl alcohols, gums, polyalkylene glycols, and petroleum jelly. Preferred formulations are more fully illustrated in Example 6.

The compounds of the present invention are administered in pharmaceutical formulations comprising the compound in admixture with a pharmaceutical carrier suitable for enteral or patenteral administration. The formulations may be in solid form, for example tablets and capsules, or in liquid form, for example syrups, elixirs, emulsions, and injectables. In the formulation of pharmaceutical dosage forms there generally is utilized excipients, for example, water, gelatin, lactose, starches, magnesium stearate, talc, vegetable oils, benzyl alcohols, gums, polyalkylene glycols, and petroleum jelly. Preferred formulations are more fully illustrated in Example 6.

Although the required dosage will be determined by such factors as the patient's age, sex, weight and the severity of the allergic reaction to be treated, the preferred human dosage range in likely to be 4 to 50 mg of the effective compound 1 to 3 times per day. The preferred dosage ranges for other animals can readily be determined by using standard testing methods.

The following Examples are illustrative of the aforementioned pharmaceutical compositions:

EXAMPLE 6

A syrup comprising a compound of the present invention (Active Compound), e.g. 11-(N-carboethoxy-4-piperidylidene)-8-chloro-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine, 11-(N-methanesulfonyl-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine, 11-(N-carboethoxy-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine, 11-(N-carbomethoxy-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine or 11-(N-carbophenoxy-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine, is prepared from the following ingredients:

______________________________________ per ml______________________________________Active Compound 0.100 mgSucrose 600 mgSorbitol 140 mgPropylene Glycol 20.0 mgMethylparaben 1.00 mgPropylparaben 0.200 mgF.D. & C. Yellow No. 6 0.225 mgAlcohol USP 0.0021 mlLimitation Black Currant Flavor 0.001 mlPurified Water USP q.s. 1.0 ml______________________________________

The syrup is prepared by combining the above ingredients according to standard techniques.

EXAMPLE 7

A tablet comprising a compound of the present invention (Active Compound) is prepared by a spray-dry process from the following ingredients:

______________________________________ mg/tablet______________________________________Component IActive Compound 1.00Lactose, Hydrous USP (Impalpable 212Powder)Povidone NF 10.0Corn Starch (Food Grade) 15.0Purified Water USP (Evaporates) 0.102 mlAdditional ComponentsCorn Starch (Food Grade) 11.5Magnesium Stearate USP 0.500______________________________________

The materials of Component I are combined and spray dried by standard techniques. The resulting spray dried material is combined with the additional components listed above and processed to form tablets.

Claims

1. A compound having the structural formula ##STR13## wherein ring ##STR14## is a 5- or 6-membered, aromatic, non-nitrogen containing heterocycle; ring ##STR15## is ortho-phenylene or orthophenylene substituted with halo; Z represents a bond or an alkylene chain having 1 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen or a hydroxy group as a substituent; W is ##STR16## wherein n is 1 or 2, R.sub.2 is hydrogen or C.sub.1 to C.sub.3 alkyl, and the dotted line represents an optional double bond, R.sup.2 being absent if the double bond is present, and Y is --COOR or --SO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl, and with the proviso that when Y is SO.sub.2 R, R is selected from C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.

2. A compound defined in claim 1 wherein ring A is a thiophene ring.

3. A compound having the structural formula ##STR17## wherein ring ##STR18## is a 5 or 6-membered, aromatic, non-nitrogen containing heterocycle; ring ##STR19## is ortho-phenylene or ortho-phenylene substituted with halo; Z represents a bond or an alkylene chain having 1 to 2 carbon atoms in the chain; said chain having either a carbonyl oxygen or an hydroxy group as a substituent; W is ##STR20## wherein n is 1 or 2, R.sub.2 is hydrogen or C.sub.1 to C.sub.3 alkyl, and the dotted line represents an optional double bond, R.sub.2 being absent if the double bond is present, and Y is --COOR or --SO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl, and with the proviso that when Y is SO.sub.2 R, R is selected from C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.

4. A compound defined in claim 3 having the structural formula: ##STR21##

5. A compound having the structural formula ##STR22## wherein n is 1 or 2, and Y is --COOR or --CO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl and with the proviso that when Y is SO.sub.2 R, R is selected from C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.

6. A compound defined in claim 5 having the structural formula ##STR23##

7. A compound defined in claim 6 wherein Y is COOR.

8. The compound defined in claim 7 wherein R is C.sub.2 H.sub.5.

9. A pharmaceutical composition which comprises an anti-allergic effective amount of a compound having the structural formula ##STR24## in combination with a pharmaceutically acceptable carrier, wherein ring ##STR25## is a 5 or 6-membered, aromatic, non-nitrogen containing heterocycle; ring ##STR26## is ortho-phenylene or orthophenylene substituted with halo; Z represents a bond or an alkylene chain having 1 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen or an hydroxy group as a substituent; W is ##STR27## wherein n is 1 or 2, R.sub.2 is hydrogen or C.sub.1 to C.sub.3 alkyl, and the dotted line represents an optional double bond, R.sup.2 being absent if the double bond is present, and Y is --COOR or --SO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl, and with the proviso that when Y is SO.sub.2 R, R is selected from C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.

10. A method of effecting an anti-allergic response in a mammal which comprises administering to said mammal an anti-allergic effective amount of a composition comprising a compound having the structural formula ##STR28## in combination with a pharmaceutically acceptable carrier, wherein ring ##STR29## is a 5 or 6-membered, aromatic, non-nitrogen containing heterocycle; ring ##STR30## is ortho-phenylene or ortho-phenylene substituted with halo; Z represents a bond or an alkylene chain having 1 or 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen or an hydroxy group as a substituent; W is ##STR31## wherein n is 1 or 2, R.sub.2 is hydrogen or C.sub.1 to C.sub.3 alkyl, and the dotted line represents an optional double bond, R.sup.2 being absent if the double bond is present, and Y is --COOR or --SO.sub.2 R, with the proviso that when Y is --COOR, R is C.sub.1 to C.sub.12 alkyl, substituted C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, substituted C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C.sub.1 to C.sub.12 alkyl and on said substituted C.sub.2 to C.sub.12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C.sub.1 to C.sub.6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo, and the substituent on said N-substituted piperidyl is C.sub.1 to C.sub.4 alkyl, and with the proviso that when Y is SO.sub.2 R, R is selected from C.sub.1 to C.sub.12 alkyl, C.sub.2 to C.sub.12 alkenyl, phenyl, substituted phenyl, C.sub.7 to C.sub.10 phenylalkyl, C.sub.7 to C.sub.10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C.sub.7 to C.sub.10 phenylalkyl are selected from C.sub.1 to C.sub.4 alkyl and halo.