Claims
- 1. A tricyclic compound represented by formula (I): ##STR262## wherein
- represents single bond or double bond;
- X.sub.1 -X.sub.2 represents --CH.sub.2 --CH.sub.2 --, or --CH.dbd.CH--;
- W represents --S-- or .dbd.CH--;
- n is 1, 2, 3, or 4;
- one of R.sup.A and R.sup.B represents hydrogen and the other represents --Y--M wherein Y represents single bond, --CR.sup.1 R.sup.2 --(CH.sub.2).sub.m --, or --CR.sup.1 .dbd.CR.sup.2 --(CH.sub.2).sub.m -- wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or lower alkyl and m is 0, 1, 2, 3 or 4, in which the left side of each formula is bound to the mother nucleus; and M represents --CONR.sup.3a R.sup.3b wherein each of R.sup.3a and R.sup.3b independently has the same significances for R.sup.3 as described above, or tetrazolyl;
- each of G.sup.A and G.sup.B independently represents lower alkyl, halogen, hydroxyl, or lower alkoxyl;
- each of g.sup.A and g.sup.B independently represents 0, 1, 2 or 3;
- Z represents ##STR263## wherein Q represents aryl, aralkyl or aralkenyl which is optionally substituted with 1 to 3 substituents independently selected from the group consisting of lower alkyl, halogen, trifluoromethyl, hydroxyl, lower alkoxyl and methylene dioxy formed together with the ortho-position of the aromatic ring;
- wherein L represents hydrogen, hydroxyl, or lower alkoxy; and E.sup.2 represents single bond, --CO--, or ##STR264## wherein R.sup.4 represents hydrogen or lower alkyl; >C.dbd.CH--Q wherein Q has the same significance as described above;
- p is 1, 2 or 3;
- and a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1, wherein one of R.sup.A and R.sup.B represents hydrogen and the other represents --Y--COOH.
- 3. A compound according to claim 2, wherein Y is a member selected from the group consisting of single bond, --CH.sub.2 --, ##STR265## and --CH.sub.2 CH.sub.2 --.
- 4. A compound according to any one of claims 1-3 wherein Z is ##STR266## and p is 2 or 3.
- 5. A compound according to 4, wherein Q represents optionally substituted aryl having 6 to 10 carbon atoms, optionally substituted aralkyl having 7 to 20 carbon atoms or optionally substituted aralkenyl having 8 to 18 carbon atoms.
- 6. A compound according to any one of claims 1-3 wherein p is 2; and Z is ##STR267## wherein L represents hydrogen or hydroxyl, E.sup.2 represents single bond or --CO--, and Q is selected from the group consisting of optionally substituted phenyl, optionally substituted benzyl, optionally substituted benzhydryl, phenethyl, stryl, and cinnamyl.
- 7. A compound according to claim 1, wherein said salt is selected from the group consisting of acid addition salt, metal salt, ammonium salt, organic amine addition salt and amino acid addition salt.
- 8. 5-[2-(4-Benzyl-1-piperidinyl)ethyl]thio-5 H-dibenzo [a,d]-cyclohepten-3-carboxylic acid.
- 9. 5-[2-(4-Benzyl-1-piperidinyl)ethyl]thio-10, 11-dihydro-5 H-dibenzo[a,d]cyclohepten-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
- 10. A pharmaceutical composition comprising a pharmaceutical carrier and, as an active ingredient, an effective amount of a tricyclic compound as defined by claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
62-315769 |
Dec 1987 |
JPX |
|
63-23543 |
Feb 1988 |
JPX |
|
Parent Case Info
This application is a division of application Ser. No. 616,095, filed Nov. 20, 1990, now U.S. Pat. No. 5,143,922 which is a division of application Ser. No. 281,545, filed Dec. 8, 1988, now U.S. Pat. No. 4,994,463.
US Referenced Citations (7)
Foreign Referenced Citations (13)
Number |
Date |
Country |
0085870 |
Aug 1983 |
EPX |
188802 |
Jul 1986 |
EPX |
214779 |
Mar 1987 |
EPX |
0235796 |
Sep 1987 |
EPX |
2407661 |
Aug 1974 |
DEX |
152673 |
Jul 1986 |
JPX |
152674 |
Jul 1986 |
JPX |
152675 |
Jul 1986 |
JPX |
152676 |
Jul 1986 |
JPX |
257981 |
Nov 1986 |
JPX |
153280 |
Jul 1987 |
JPX |
1330966 |
Sep 1973 |
GBX |
1347935 |
Feb 1974 |
GBX |
Non-Patent Literature Citations (7)
Entry |
Arz.--Forsch., 13, 1039 (1963). |
Arz.-Forsch., 14, 100 (1964). |
J. Med. Chem. 21, 633 (1978). |
Chem. Abstracts, vol. 72, 308 (1970) No. 3387d. |
Chem. Abstracts, vol. 81, 424 (1974), No. 25566z. |
Eur. J. Med. Chem.-Chimica Therapeutica, P. Dostert et al., "Composes Tricycliques portant une chaine alkylaminoalkylthio. Synthese et activite pharmacologique," May-Jun. 1974-9, No. 3, p. 259. |
J. Med. Chem., M. Cerelli et al., "Antiinflammatory and Aldose Reductase Inhibitory Activity of Some Tricyclic Arylacetic Acids," vol. 29, 2347 (1986). |
Divisions (2)
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Number |
Date |
Country |
Parent |
616095 |
Nov 1990 |
|
Parent |
281545 |
Dec 1988 |
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