Claims
- 1. A compound of the formula: ##STR10## wherein R.sup.1 is hydroxy or pharmaceutically acceptable protected hydroxy selected from the group consisting of 1-(lower alkylthio) (lower)alkyloxy, tri(lower)alkylsilyloxy, lower alkyldiphenyl-silyloxy, pharmaceutically acceptable organic carboxylic acyloxy, pharmaceutically acceptable organic sulfonic acyloxy, and pharmaceutically acceptable organic carbamic acyloxy,
- R.sup.2 is hydrogen or the same meanings as R.sup.1,
- R.sup.3 is methyl, ethyl, propyl or allyl,
- n is an integer of 1 or 2, and
- the symbol of a line and dotted line is a single bond or a double bond, provided that when R.sup.1 and R.sup.2 are each hydroxy, n is an integer of 2 and the symbol of a line and dotted line is a single bond, then R.sup.3 is methyl, propyl or allyl, and a pharmaceutically acceptable basic salt thereof.
- 2. The compound of claim 1, wherein
- R.sup.1 is hydroxy, C.sub.1 -C.sub.4 -alkanoyloxy which may have carboxy, cyclo (C.sub.5 -C.sub.6)alkyloxy(C.sub.1 -C.sub.4)-alkanoyloxy having two (C.sub.1 -C.sub.4)-alkyl groups on the cycloalkyl moiety, camphorsulfonyloxy, carboxy(C.sub.1 -C.sub.4)-alkylcarbamoyloxy, tri(C.sub.1 -C.sub.4)alkylsilyl-(C.sub.1 -C.sub.4)alkoxycarbonyl(C.sub.1 -C.sub.4)alkylcarbamoyloxy, benzoyloxy which may have one or two nitro, benzenesulfonyloxy having halogen, or phenyl(C.sub.1 -C.sub.4)alkanoyloxy having C.sub.1 -C.sub.4 alkoxy and trihalo(C.sub.1 -C.sub.4)alkyl, and
- R.sup.2 is hydrogen, hydroxy or C.sub.1 -C.sub.4 -alkanoyloxy.
- 3. The compound of claim 2, wherein R.sup.1 is carboxy(C.sub.1 -C.sub.4)alkylcarbamoyloxy or tri(C.sub.1 -C.sub.4)alkylsilyl(C.sub.1 -C.sub.4)-alkoxycarbonyl(C.sub.1 -C.sub.4)alkylcarbamoyloxy.
- 4. The compound of claim 3, wherein n is an integer of 2.
- 5. The compound of claim 4, wherein the symbol of a line and dotted line is a single bond.
Priority Claims (3)
Number |
Date |
Country |
Kind |
8430455 |
Dec 1984 |
GBX |
|
8502869 |
Feb 1985 |
GBX |
|
8508420 |
Apr 1985 |
GBX |
|
Parent Case Info
This is a continuation of application Ser. No. 07/606,328, filed on Oct. 31, 1990, abandoned, which is a division of Ser. No. 07/491,205, filed Mar. 9, 1990, continuation of U.S. Pat. No. 5,110,811, which is a continuation of Ser. No. 06/868,749, filed on May 30, 1986, now U.S. Pat. No. 4,921,611, which is a continuation in part of Ser. No. 06/799,855, filed on Nov. 20, 1985, now U.S. Pat. No. 4,894,366.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4894366 |
Okuhara et al. |
Jan 1990 |
|
4929611 |
Okuhara et al. |
May 1990 |
|
5110811 |
Okuhara et al. |
May 1992 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
491205 |
Mar 1990 |
|
Continuations (2)
|
Number |
Date |
Country |
Parent |
606328 |
Oct 1990 |
|
Parent |
868749 |
May 1986 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
799855 |
Nov 1985 |
|