Claims
- 1. A compound of the formula ##STR51## wherein X is ##STR52## n is zero, 1 or 2; R.sub.1 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR53## R.sub.2 and R.sub.9 are independently hydroxy, lower alkoxy, (phenyl)lower alkoxy, ##STR54## --O.sup.- M.sup.+ where M.sup.+ is a salt forming metal ion, ##STR55## or --NRR'; R and R' are independently hydrogen, alkyl or ##STR56## R.sub.3 is hydrogen or ##STR57## R.sub.4 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, hydroxy, CF.sub.3, phenyl, ##STR58## R.sub.5 is lower alkyl ##STR59## --(CH.sub.2).sub.q -(.alpha.-naphthyl), --(CH.sub.2).sub.q -(.beta.-naphthyl), or --(CH.sub.2).sub.q -cycloalkyl;
- R.sub.6 is hydrogen, lower alkyl, cycloalkyl or phenyl;
- R.sub.7 is hydrogen, lower alkyl, lower alkoxy or phenyl;
- r is an integer from 1 to 4; and
- q is zero or an interger from 1 to 7.
- 2. A compound of claim 1 wherein
- R.sub.3 is hydrogen or ##STR60## n is zero; and X is ##STR61##
- 3. A pharmaceutical composition useful for reducing blood pressure and producing diuresis and natriuresis as well as treating congestive heart failure, renal failure, or hepatic cirrhosis comprising a pharmaceutically acceptable carrier and an effective amount of an endopeptidase inhibiting compound of the formula ##STR62## wherein X, n and R.sub.3 are as defined in claim 1.
- 4. The compound of claim 2, (S)-1-[N-3,3,3-trifluoro-2-(mercaptomethyl)-1-oxopropyl]-L-alanyl]-L-proline.
- 5. The compound of claim 2, (R)-1-[N-[3,3,3-trifluoro-2-(mercaptomethyl)-1-oxopropyl]-L-alanyl]-L-proline.
RELATED APPLICATION
This application is a division of Ser. No. 690,436 filed Apr. 24, 1991, now U.S. Pat. No. 5,233,516, which is a continuation-in-part of Ser. No. 497,386 filed Mar. 22, 1990, now abandoned.
US Referenced Citations (14)
Foreign Referenced Citations (7)
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Oct 1981 |
BEX |
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EPX |
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Divisions (1)
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Number |
Date |
Country |
Parent |
690436 |
Apr 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
497386 |
Mar 1990 |
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