Claims
- 1. A compound having the formula: ##STR115## wherein R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group;
- the two R.sup.2 groups, taken together, represent a bridging group serving complete a macrocyclic ring, the bridging group containing at least one heteroatom and at least one alkylene group which form part of the resulting macrocyclic ring;
- R.sup.3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl, or a protein reactive group;
- R.sup.5 represents alkyl or alkoxy; and
- R.sup.6 represents a protein reactive group.
- 2. The compound of claim 1 wherein R.sup.5 is methoxy.
- 3. The compound of claim 1 wherein R.sup.6 is selected from the group consisting of amino, alkylamino, arylamino, carbazido, semicarbazido, thiocarbazido, thiosemicarbazido, isocyanato and isothiocyanato.
- 4. The compound of claim 1 wherein R.sup.6 is selected from the group consisting of amino, isothiocyanato and thiocarbazido.
- 5. The compound of claim 1 wherein R.sup.5 is 3-methoxy and R.sup.6 is 4-amino.
- 6. The compound of claim 1 wherein each R.sup.3 is H.
Parent Case Info
This application is a continuation of application Ser. No. 07,784,333, filed Oct. 29,1991, now U.S. Pat. No. 5,367,080 which is a continuation-in-part application of U.S. patent application Ser. No. 07/610,861 filed Nov. 8, 1990, now abandoned.
US Referenced Citations (10)
Continuations (1)
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Date |
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Parent |
784333 |
Oct 1991 |
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Continuation in Parts (1)
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610861 |
Nov 1990 |
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